CN106854180B - 一种4-氯-7-甲氧基喹啉-6-酰胺的制备方法 - Google Patents
一种4-氯-7-甲氧基喹啉-6-酰胺的制备方法 Download PDFInfo
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- CN106854180B CN106854180B CN201611078325.7A CN201611078325A CN106854180B CN 106854180 B CN106854180 B CN 106854180B CN 201611078325 A CN201611078325 A CN 201611078325A CN 106854180 B CN106854180 B CN 106854180B
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
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CN201611078325.7A CN106854180B (zh) | 2016-11-30 | 2016-11-30 | 一种4-氯-7-甲氧基喹啉-6-酰胺的制备方法 |
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CN201611078325.7A CN106854180B (zh) | 2016-11-30 | 2016-11-30 | 一种4-氯-7-甲氧基喹啉-6-酰胺的制备方法 |
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CN106854180A CN106854180A (zh) | 2017-06-16 |
CN106854180B true CN106854180B (zh) | 2018-08-31 |
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CN201611078325.7A Active CN106854180B (zh) | 2016-11-30 | 2016-11-30 | 一种4-氯-7-甲氧基喹啉-6-酰胺的制备方法 |
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Families Citing this family (2)
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CN112110856B (zh) * | 2020-10-25 | 2022-09-06 | 南京法恩化学有限公司 | 一种4-氯-7-甲氧基喹啉-6-酰胺的制备方法 |
CN116874420B (zh) * | 2023-06-25 | 2024-03-26 | 山东轩德医药科技有限公司 | 一种乐伐替尼中间体4-氯-7-甲氧基喹啉-6-酰胺的制备方法 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9904103D0 (en) * | 1999-02-24 | 1999-04-14 | Zeneca Ltd | Quinoline derivatives |
ES2318649T3 (es) * | 2000-10-20 | 2009-05-01 | EISAI R&D MANAGEMENT CO., LTD. | Procedimiento de preparacion de derivados de 4-fenoxi quinolinas. |
US20070117842A1 (en) * | 2003-04-22 | 2007-05-24 | Itaru Arimoto | Polymorph of 4-[3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy]-7-methoxy-6- quinolinecarboxamide and a process for the preparation of the same |
CN101337930B (zh) * | 2003-11-11 | 2010-09-08 | 卫材R&D管理有限公司 | 脲衍生物的制备方法 |
WO2005080377A1 (ja) * | 2004-02-20 | 2005-09-01 | Kirin Beer Kabushiki Kaisha | TGFβ阻害活性を有する化合物およびそれを含んでなる医薬組成物 |
CN101437811A (zh) * | 2006-03-02 | 2009-05-20 | 阿斯利康(瑞典)有限公司 | 喹啉衍生物 |
CA2682504C (en) * | 2007-04-05 | 2012-10-30 | Amgen Inc. | Aurora kinase modulators and method of use |
CN104211686A (zh) * | 2013-06-03 | 2014-12-17 | 天津隆博基因药物科技有限公司 | 喹啉类衍生物及其治疗用途 |
US10654808B2 (en) * | 2015-04-07 | 2020-05-19 | Guangdong Raynovent Biotech Co., Ltd. | Tyrosine kinase inhibitor and pharmaceutical composition comprising same |
CN105111141A (zh) * | 2015-09-02 | 2015-12-02 | 苏州摩尔医药有限公司 | 一种卡博替尼中间体4-羟基6,7-二甲氧基喹啉及其制备方法 |
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Effective date of registration: 20180802 Address after: 250000 Room 202, North Tower, 2766 Yingxiu Road, hi tech Zone, Ji'nan, Shandong. Applicant after: Ji'nan Xuan de Chemical Co., Ltd. Applicant after: Shandong Xuan Pharmaceutical Technology Co., Ltd. Address before: Room 437, a comprehensive building, 271000, west of Taishan Road, north of Mengguan Road, south of Changjiang Road and east of Jinshuihu Lake, Ningyang County Economic Development Zone, Taian City, Shandong Province Applicant before: Shandong Xuan Pharmaceutical Technology Co., Ltd. |
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