CN106853246B - 一种布鲁氏菌病温敏凝胶剂型疫苗 - Google Patents
一种布鲁氏菌病温敏凝胶剂型疫苗 Download PDFInfo
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- CN106853246B CN106853246B CN201710028545.7A CN201710028545A CN106853246B CN 106853246 B CN106853246 B CN 106853246B CN 201710028545 A CN201710028545 A CN 201710028545A CN 106853246 B CN106853246 B CN 106853246B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/098—Brucella
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/542—Mucosal route oral/gastrointestinal
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/543—Mucosal route intranasal
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
- A61K2039/552—Veterinary vaccine
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- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Description
配方一 | 配方二 | 配方三 | 配方四 | |
泊洛沙姆407/g | 1.9 | 2.0 | 2.1 | 2.2 |
泊洛沙姆188/g | 0.1 | 0.2 | 0.3 | 0.4 |
胶凝温度/℃ | 33.5 | 34.5 | 34.9 | 35.0 |
高压后温度/℃ | 34.0 | 34.3 | 35.0 | 34.8 |
滤膜过滤后温度/℃ | 33.8 | 34.8 | 35.2 | 35.3 |
模拟泪液稀释后温度/℃ | * | * | * | 48.7 |
Claims (9)
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CN201710028545.7A CN106853246B (zh) | 2017-01-16 | 2017-01-16 | 一种布鲁氏菌病温敏凝胶剂型疫苗 |
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CN201710028545.7A CN106853246B (zh) | 2017-01-16 | 2017-01-16 | 一种布鲁氏菌病温敏凝胶剂型疫苗 |
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CN106853246A CN106853246A (zh) | 2017-06-16 |
CN106853246B true CN106853246B (zh) | 2020-01-21 |
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CN201710028545.7A Active CN106853246B (zh) | 2017-01-16 | 2017-01-16 | 一种布鲁氏菌病温敏凝胶剂型疫苗 |
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Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
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CN107412758A (zh) * | 2017-07-28 | 2017-12-01 | 金宇保灵生物药品有限公司 | 用于预防羊布氏菌病的疫苗 |
CN109045293B (zh) * | 2018-08-29 | 2022-11-18 | 灵格兽医技术有限公司 | 动物布鲁氏菌病凝胶佐剂预灌装疫苗及其制备方法 |
CN113475461A (zh) * | 2021-08-11 | 2021-10-08 | 云南农业大学 | 一种牛羊养殖疾病的综合防治方法 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102327606A (zh) * | 2011-09-06 | 2012-01-25 | 中国兽医药品监察所 | 一种布鲁氏菌活疫苗及其生产方法 |
CN103751779A (zh) * | 2014-02-25 | 2014-04-30 | 中国农业科学院上海兽医研究所 | O型***多肽的泊洛沙姆凝胶佐剂 |
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2017
- 2017-01-16 CN CN201710028545.7A patent/CN106853246B/zh active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102327606A (zh) * | 2011-09-06 | 2012-01-25 | 中国兽医药品监察所 | 一种布鲁氏菌活疫苗及其生产方法 |
CN103751779A (zh) * | 2014-02-25 | 2014-04-30 | 中国农业科学院上海兽医研究所 | O型***多肽的泊洛沙姆凝胶佐剂 |
Non-Patent Citations (2)
Title |
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Pluronic P85 enhances the efficacy of outer membrane vesicles as a subunit vaccine against Brucella melitensis challenge in mice;Neeta Jain-Gupta et al.;《FEMS Immunol Med Microbiol.》;20121231;第66卷(第3期);第8页倒数第1段和第7页第1段 * |
基于纳微米颗粒和凝胶佐剂的新型疫苗传递体系;岳华等;《中国材料进展》;20150402;第34卷(第3期);第217页左栏第1-2段 * |
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Inventor after: Mao Kairong Inventor after: Zhu Liangquan Inventor after: Peng Xiaowei Inventor after: Jiang Hui Inventor after: Wang Miaomiao Inventor after: Wang Nan Inventor after: Xu Lei Inventor after: Zhang Jinya Inventor after: Zhang He Inventor after: Wan Renling Inventor after: Yu Xiaohui Inventor after: Ding Jiabo Inventor before: Mao Kairong Inventor before: Zhu Liangquan Inventor before: Peng Xiaowei Inventor before: Jiang Hui Inventor before: Wang Miaomiao Inventor before: Wang Nan Inventor before: Xu Lei Inventor before: Zhang Jinya Inventor before: Zhang He Inventor before: Wan Renling Inventor before: Yu Xiaohui Inventor before: Ding Jiabo |
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