CN106832689A - 一种药用包装材料的制备方法 - Google Patents

一种药用包装材料的制备方法 Download PDF

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CN106832689A
CN106832689A CN201611078795.3A CN201611078795A CN106832689A CN 106832689 A CN106832689 A CN 106832689A CN 201611078795 A CN201611078795 A CN 201611078795A CN 106832689 A CN106832689 A CN 106832689A
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张顺伟
唐进六
陈伟
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XUHUA PHARMACEUTICAL CO Ltd SICHUAN
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Abstract

本发明公开了一种药用包装材料的制备方法,包括以下步骤:(1)将医药或食品级聚偏二氯乙烯(PVDC)、乙烯‑丙烯共聚物混合后加热熔融,其后加入羧甲基纤维素,至三者混合均匀后加入石膏,进行高速剪切搅拌,再降低搅拌速率,加入聚乙烯吡咯烷酮和二丁基羟基甲苯,再次搅拌均匀并自然冷却,得到预混物;(2)将步骤(1)得到的预混物与茂金属聚乙烯进行共挤出,成型为膜状;(3)将步骤(2)得到的膜层通过粘结层与铝箔层复合,即得到所述药用包装材料。本发明制得的包装材料性质均一、稳定,阻湿、阻气、防氧化性能优异,药品可长期在湿热环境下存放,同时包装的加工性能好,成型难度低。

Description

一种药用包装材料的制备方法
技术领域
本发明涉及药用包装材料的技术领域,特别涉及铝塑包装材料的技术领域。
背景技术
铝塑泡罩包装大量应用于药品片剂、胶囊的包装中,现有技术中这类包装材料通常存在阻隔性能欠佳,特别是阻湿、阻气性能不太理想,导致药品在存放时出现变质的现象。
发明内容
本发明的目的在于提出一种具有高效的阻湿、阻气、防氧化性能的药用包装材料的制备方法。
本发明的技术方案如下:
一种药用包装材料的制备方法,包括以下步骤:
(1)将医药或食品级聚偏二氯乙烯(PVDC)、乙烯-丙烯共聚物混合后加热熔融,并在搅拌状态下加入羧甲基纤维素,至三者混合均匀,其后向熔融物中加入石膏,进行高速剪切搅拌,再降低搅拌速率,向混合物中加入聚乙烯吡咯烷酮和二丁基羟基甲苯,再次搅拌均匀并自然冷却,得到预混物;
(2)将步骤(1)得到的预混物与茂金属聚乙烯进行共挤出,成型为膜状;
(3)将步骤(2)得到的膜层通过粘结层与铝箔层复合,即得到所述药用包装材料。
优选的是:所述预混物按质量份计,包括聚偏二氯乙烯15~20份,乙烯-丙烯共聚物3~5份,羧甲基纤维素1~1.5份,聚乙烯吡咯烷酮0.8~1.2份,二丁基羟基甲苯0.1~0.3份,石膏0.5~1份。
另外优选的是:所述预混物按质量份计,所述预混物按质量份计,包括聚偏二氯乙烯15份,乙烯-丙烯共聚物3份,羧甲基纤维素1.2份,聚乙烯吡咯烷酮1.0份,二丁基羟基甲苯0.2份,石膏0.8份。
本发明制得的包装材料性质均一、稳定,可用于片剂、药丸、胶囊等剂型的包装,阻湿、阻气、防氧化性能优异,药品可长期在湿热环境下存放,同时包装的加工性能好,成型难度低。
具体实施方式
实施例1
(1)将医药或食品级聚偏二氯乙烯(PVDC)15份、乙烯-丙烯共聚物3份混合后加热熔融,并在搅拌状态下加入羧甲基纤维素1份,至三者混合均匀,其后向熔融物中加入石膏0.5份,进行高速剪切搅拌,再降低搅拌速率,向混合物中加入聚乙烯吡咯烷酮0.8份和二丁基羟基甲苯0.1份,再次搅拌均匀并自然冷却,得到预混物;
(2)将步骤(1)得到的预混物与茂金属聚乙烯进行共挤出,成型为膜状;
(3)将步骤(2)得到的膜层通过粘结层与铝箔层复合,即得到所述药用包装材料。
实施例2
(1)将医药或食品级聚偏二氯乙烯(PVDC)20份、乙烯-丙烯共聚物5份混合后加热熔融,并在搅拌状态下加入羧甲基纤维素1.5份,至三者混合均匀,其后向熔融物中加入石膏1份,进行高速剪切搅拌,再降低搅拌速率,向混合物中加入聚乙烯吡咯烷酮1.2份和二丁基羟基甲苯0.3份,再次搅拌均匀并自然冷却,得到预混物;
(2)将步骤(1)得到的预混物与茂金属聚乙烯进行共挤出,成型为膜状;
(3)将步骤(2)得到的膜层通过粘结层与铝箔层复合,即得到所述药用包装材料。
实施例3
(1)将医药或食品级聚偏二氯乙烯(PVDC)15份、乙烯-丙烯共聚物3份混合后加热熔融,并在搅拌状态下加入羧甲基纤维素1.2份,至三者混合均匀,其后向熔融物中加入石膏0.8份,进行高速剪切搅拌,再降低搅拌速率,向混合物中加入聚乙烯吡咯烷酮1.0份和二丁基羟基甲苯0.2份,再次搅拌均匀并自然冷却,得到预混物;
(2)将步骤(1)得到的预混物与茂金属聚乙烯进行共挤出,成型为膜状;
(3)将步骤(2)得到的膜层通过粘结层与铝箔层复合,即得到所述药用包装材料。

Claims (3)

1.一种药用包装材料的制备方法,其特征在于:包括以下步骤:
(1)将医药或食品级聚偏二氯乙烯(PVDC)、乙烯-丙烯共聚物混合后加热熔融,并在搅拌状态下加入羧甲基纤维素,至三者混合均匀,其后向熔融物中加入石膏,进行高速剪切搅拌,再降低搅拌速率,向混合物中加入聚乙烯吡咯烷酮和二丁基羟基甲苯,再次搅拌均匀并自然冷却,得到预混物;
(2)将步骤(1)得到的预混物与茂金属聚乙烯进行共挤出,成型为膜状;
(3)将步骤(2)得到的膜层通过粘结层与铝箔层复合,即得到所述药用包装材料。
2.根据权利要求1所述的药用包装材料的制备方法,其特征在于:所述预混物按质量份计,包括聚偏二氯乙烯15~20份,乙烯-丙烯共聚物3~5份,羧甲基纤维素1~1.5份,聚乙烯吡咯烷酮0.8~1.2份,二丁基羟基甲苯0.1~0.3份,石膏0.5~1份。
3.根据权利要求1所述的药用包装材料的制备方法,其特征在于:所述预混物按质量份计,包括聚偏二氯乙烯15份,乙烯-丙烯共聚物3份,羧甲基纤维素1.2份,聚乙烯吡咯烷酮1.0份,二丁基羟基甲苯0.2份,石膏0.8份。
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CN102443231A (zh) * 2011-11-07 2012-05-09 中国科学院宁波材料技术与工程研究所 一种消除晶点、提高阻隔的pvdc薄膜的制造方法
CN103756095A (zh) * 2014-01-15 2014-04-30 佛山市南方包装有限公司 一种阻湿阻气的高阻隔彩色塑料制品

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