CN106795196A - 十六元大环内酯类化合物及其应用 - Google Patents

十六元大环内酯类化合物及其应用 Download PDF

Info

Publication number
CN106795196A
CN106795196A CN201580013257.3A CN201580013257A CN106795196A CN 106795196 A CN106795196 A CN 106795196A CN 201580013257 A CN201580013257 A CN 201580013257A CN 106795196 A CN106795196 A CN 106795196A
Authority
CN
China
Prior art keywords
hexa
application
insect
preventing
prepared
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201580013257.3A
Other languages
English (en)
Inventor
黄隽
王继栋
张辉
王玲萍
李娜
李美红
白骅
金旻琦
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zhejiang Hisun Chemical Co ltd
Zhejiang Hisun Pharmaceutical Co Ltd
Original Assignee
Zhejiang Hisun Chemical Co ltd
Zhejiang Hisun Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zhejiang Hisun Chemical Co ltd, Zhejiang Hisun Pharmaceutical Co Ltd filed Critical Zhejiang Hisun Chemical Co ltd
Priority claimed from PCT/CN2015/073960 external-priority patent/WO2015135467A1/zh
Publication of CN106795196A publication Critical patent/CN106795196A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • C12P19/623—Avermectin; Milbemycin; Ivermectin; C-076
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/76—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Actinomyces; for Streptomyces
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Pest Control & Pesticides (AREA)
  • Dentistry (AREA)
  • Environmental Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Saccharide Compounds (AREA)

Abstract

本发明提出了一种十六元大环内酯类化合物及其应用，其中该化合物的结构通式如下：所述R为CH3或C2H5。该化合物在制备防治农林害虫和害螨药物中具有广泛的应用。

Description

PCT国内申请，说明书已公开。

Claims (15)

  1. PCT国内申请，权利要求书已公开。
CN201580013257.3A 2014-03-10 2015-03-10 十六元大环内酯类化合物及其应用 Pending CN106795196A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201410085431 2014-03-10
CN2014100854312 2014-03-10
PCT/CN2015/073960 WO2015135467A1 (zh) 2014-03-10 2015-03-10 十六元大环内酯类化合物及其应用

Publications (1)

Publication Number Publication Date
CN106795196A true CN106795196A (zh) 2017-05-31

Family

ID=54070849

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201480077055.0A Active CN106459885B (zh) 2014-03-10 2014-04-28 表达阿维菌素类似物的重组微生物及其用途
CN201580013257.3A Pending CN106795196A (zh) 2014-03-10 2015-03-10 十六元大环内酯类化合物及其应用

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CN201480077055.0A Active CN106459885B (zh) 2014-03-10 2014-04-28 表达阿维菌素类似物的重组微生物及其用途

Country Status (12)

Country Link
US (1) US10334850B2 (zh)
EP (1) EP3118305B1 (zh)
JP (1) JP6346673B2 (zh)
CN (2) CN106459885B (zh)
AU (1) AU2014386509B2 (zh)
CA (1) CA2940016A1 (zh)
CL (1) CL2016002223A1 (zh)
EA (1) EA033293B1 (zh)
IL (1) IL247596B (zh)
MX (1) MX2016011367A (zh)
UA (1) UA116835C2 (zh)
WO (1) WO2015135242A1 (zh)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110540567A (zh) * 2018-05-28 2019-12-06 浙江海正药业股份有限公司 一种天维菌素b的晶型及其制备方法和用途
CN114931144A (zh) * 2022-06-21 2022-08-23 台州科技职业学院 一种大环内酯类化合物及其在防治农林害虫和害螨中的应用

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017052232A1 (ko) * 2015-09-22 2017-03-30 주식회사 팜한농 밀베마이신을 생산하는 재조합 미생물 및 이를 이용한 밀베마이신 생산
EP3613842B1 (en) * 2017-03-13 2022-10-19 Zhejiang Hisun Pharmaceutical Co., Ltd. Ivermectin b1b producing strain and use thereof
CN108660101B (zh) * 2017-04-01 2021-07-09 浙江海正药业股份有限公司 表达天维菌素b的重组微生物、制备方法及其用途
CN107494559B (zh) * 2017-08-29 2020-09-29 浙江农林大学 防治柑桔潜叶蛾的杀虫组合物及其用途
CN107509735B (zh) * 2017-08-29 2020-09-11 浙江农林大学 增效杀螨组合物及其用途
CN110540944B (zh) * 2018-05-28 2022-08-02 深圳市天维生物药业有限公司 一种天维菌素产生菌及其应用
CN110540556B (zh) * 2018-05-28 2023-04-28 深圳市天维生物药业有限公司 一种分离和提纯天维菌素的方法
CN110305818A (zh) * 2019-08-15 2019-10-08 齐鲁制药（内蒙古）有限公司 一种阿维菌素菌种选育方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4156720A (en) * 1977-04-11 1979-05-29 Merck & Co., Inc. Carbohydrate derivatives of milbemycin and processes therefor
EP0235085A1 (de) * 1986-02-20 1987-09-02 Ciba-Geigy Ag 13-Beta-Zuckerderivate von Milbemycinen, deren Herstellung und Verwendung gegen Ekto-und Endoparasiten am Nutztier oder an der Nutzpflanze
DE4031039A1 (de) * 1989-10-03 1991-04-11 Ciba Geigy Ag 13(alpha)-zuckerderivate von milbemycinen, deren herstellung und verwendung gegen ekto- und endoparasiten am nutztier
US20110201567A1 (en) * 2010-01-22 2011-08-18 University Of Southern California Ivermectin Antagonizes Ethanol Inhibition in P2X4 Receptors
CN104910228A (zh) * 2014-03-10 2015-09-16 浙江农林大学 十六元大环内酯类化合物及其应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5234831A (en) * 1987-01-23 1993-08-10 Pfizer Inc Cultures for production of B avermectins
JP2888586B2 (ja) * 1990-03-05 1999-05-10 社団法人北里研究所 エバーメクチンの特定成分を選択生産するための微生物およびその選択的製造法
CN103834605B (zh) * 2012-11-21 2018-09-21 中国科学院上海有机化学研究所 一种阿维菌素产生菌及其制备方法和应用

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4156720A (en) * 1977-04-11 1979-05-29 Merck & Co., Inc. Carbohydrate derivatives of milbemycin and processes therefor
EP0235085A1 (de) * 1986-02-20 1987-09-02 Ciba-Geigy Ag 13-Beta-Zuckerderivate von Milbemycinen, deren Herstellung und Verwendung gegen Ekto-und Endoparasiten am Nutztier oder an der Nutzpflanze
DE4031039A1 (de) * 1989-10-03 1991-04-11 Ciba Geigy Ag 13(alpha)-zuckerderivate von milbemycinen, deren herstellung und verwendung gegen ekto- und endoparasiten am nutztier
US20110201567A1 (en) * 2010-01-22 2011-08-18 University Of Southern California Ivermectin Antagonizes Ethanol Inhibition in P2X4 Receptors
CN104910228A (zh) * 2014-03-10 2015-09-16 浙江农林大学 十六元大环内酯类化合物及其应用

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
李靖，等: "伊维菌素和阿维菌素的生物活性比较", 《粮食安全与植保科技创新》 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110540567A (zh) * 2018-05-28 2019-12-06 浙江海正药业股份有限公司 一种天维菌素b的晶型及其制备方法和用途
CN114931144A (zh) * 2022-06-21 2022-08-23 台州科技职业学院 一种大环内酯类化合物及其在防治农林害虫和害螨中的应用

Also Published As

Publication number Publication date
UA116835C2 (uk) 2018-05-10
EP3118305A1 (en) 2017-01-18
CA2940016A1 (en) 2015-09-17
EA033293B1 (ru) 2019-09-30
MX2016011367A (es) 2017-02-02
EP3118305A4 (en) 2018-03-21
AU2014386509B2 (en) 2018-07-05
EP3118305B1 (en) 2019-08-14
US10334850B2 (en) 2019-07-02
JP2017512465A (ja) 2017-05-25
WO2015135242A1 (zh) 2015-09-17
CN106459885B (zh) 2019-07-23
CN106459885A (zh) 2017-02-22
JP6346673B2 (ja) 2018-06-20
US20170013837A1 (en) 2017-01-19
IL247596A0 (en) 2016-11-30
EA201691754A1 (ru) 2016-12-30
CL2016002223A1 (es) 2017-04-07
IL247596B (en) 2019-05-30
AU2014386509A1 (en) 2016-09-22

Similar Documents

Publication Publication Date Title
CN106795196A (zh) 十六元大环内酯类化合物及其应用
JP6359696B2 (ja) 十六員環マクロライド化合物、及びその利用
CN102219815B (zh) 六种台勾霉素类化合物及其制备方法和在制备抗菌药物中的应用
WO2014059275A2 (en) Streptomyces microflavus strains and methods of their use to control plant diseases and pests
CN116784353B (zh) 野尻链霉菌菌株及其发酵液在抑制抗咪鲜胺锰盐的双孢蘑菇疣孢霉菌中的应用
CN110540556B (zh) 一种分离和提纯天维菌素的方法
CN107523562A (zh) Fosmid 文库抗瓜类枯萎病活性产物筛选与鉴定方法
CN108101778A (zh) 一种来自解淀粉芽孢杆菌sqr9产生的十四碳链脂肪酸类拮抗物质及其应用
CN101475948A (zh) 合成苏云金素的基因簇
CN113980945B (zh) 绿色木霉组蛋白去乙酰化酶及其编码基因和应用
CN107557376B (zh) 用于生产拉沙里菌素的工程菌及其制备方法与应用
US20140106406A1 (en) Gene cluster for the production of gougerotin, gougerotin analogues, and precursors thereof
KR101849374B1 (ko) 진딧물에 대한 방제활성을 갖는 신규한 슈도모나스속 ｄｊ15 균주
Maity et al. Biochemically Synthesized Potential Aminocoumarin-Glycoside Antibiotics.
CN112898389A (zh) 一种编码蛋白序列及其应用
Kolomiets et al. New approaches in development of biological control products

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
AD01 Patent right deemed abandoned

Effective date of abandoning: 20200211

AD01 Patent right deemed abandoned