CN106721319A - It is a kind of for " three-stage " composition of prevention and control porcine respiratory disease and its application - Google Patents
It is a kind of for " three-stage " composition of prevention and control porcine respiratory disease and its application Download PDFInfo
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- CN106721319A CN106721319A CN201710040157.0A CN201710040157A CN106721319A CN 106721319 A CN106721319 A CN 106721319A CN 201710040157 A CN201710040157 A CN 201710040157A CN 106721319 A CN106721319 A CN 106721319A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P60/00—Technologies relating to agriculture, livestock or agroalimentary industries
- Y02P60/80—Food processing, e.g. use of renewable energies or variable speed drives in handling, conveying or stacking
- Y02P60/87—Re-use of by-products of food processing for fodder production
Abstract
The invention discloses a kind of " three-stage " composition for prevention and control porcine respiratory disease, including for the composition A of weaned piglet phase；Composition B for the child care phase and composition C for fattening period；Wherein, described composition A includes fermentation licorice, Folium Artemisiae Argyi extract, loquat-leaf extract, coating tilmicosin phosphate preparation, zeolite powder；Described composition B includes Echinacea Purpurea Herb P.E and Astragalus Root P.E；Described composition C includes corn, dregs of beans, wheat bran and makes special premix by oneself.Additionally, being used to prepare the application of the feed addictive or feed of prevention and control porcine respiratory disease present invention additionally comprises described " three-stage " composition.The present invention carrys out the generation of prevention and control porcine respiratory disease, with ideal effect using different compositions in three stages first according to the occurrence regularity of live pig breathing problem；Can effective prevention and control breathing problem generation, with determined curative effect and the features such as be not likely to produce drug resistance and be difficult recurrence.
Description
Technical field
The invention belongs to animal veterinary drug or animal feed additive technical field, and in particular to a kind of prevention and control porcine respiratory is comprehensive
Composition and its application of disease are closed, belongs to veterinary drug and field of fodder.
Background technology
In China's pig industry, the incidence of disease of porcine respiratory disease is very high, and pathogenic factor is complicated, and preventing and treating is difficult, provisions
Pig industry brings huge economic loss.Current porcine respiratory disease is mainly numerous by mycoplasma, contagious pleuropneumonia, pig
Grow pre- with the vaccine such as respiratory disorder syndrome and PCV-II and the former net, Florfenicol of branch, Tilmicosin, tylosin medicine
It is anti-, but preferable preventive effect can not be reached, and chemoprophylaxis can also bring the generation of medicament residue and drug resistance, to pig industry
And human survival brings threat；Primary treatments after morbidity be heavy dose of use antibioticses Western medicine (such as Florfenicol,
Tilmicosin, Tiamulin, tylosin etc.) and with resolving sputum, the Chinese herbal medicine of antitussive and antiasthmatic effect and its preparation (such as balloonflower root,
Radix Glycyrrhizae, the root bark of white mulberry, Momordica grosvenori, loguat leaf, folium artemisiae argyi etc.), and antibioticses Western medicine can only treat sensitive microbial porcine respiratory
Disease, and it is invalid to the breathing problem that virus and nonpathogenic bacteria cause, even the breathing problem that treatment sensitive bacteria triggers
Also often cure the symptoms, not the disease, easily recurrent exerbation, the serious growth for influenceing live pig causes the generation of a large amount of cad pigs, or even
There is mortality.Meanwhile, the heavy dose of antibiotic, for a long time using being also easy to produce drug resistance and cause medicament residue；Chinese herbal medicine
Although clinical symptoms (resolving sputum, antibechic, relieving asthma) can be alleviated to a certain extent, and there is certain inhibitory or killing effect to pathogen,
But uncertain therapeutic efficacy is real and not sufficiently stable.The greatest problem of current preventing and treating PRDC is single prevention method,
Do not have continuity and systematicness, so control effect is undesirable.
Prior art also has some that the composition of porcine respiratory syndrome is controlled for pig；Such as Publication No.
The Chinese patent literature of CN103271966A discloses a kind of composition of control porcine respiratory syndrome, including Echinacea is extracted
Thing, nano zine oxide, Mycobacterium graminis, farrerol, deoxyglucose, astragalus polyose.
The Chinese patent literature of Publication No. CN1729831A discloses health caring feed stuff for healing pig asthma, wherein, often
Ton feed adds 300~600 grams of nano zine oxide, 50~100 grams of vitamin A, 1500~3000 grams of Folium Artemisiae Argyi extract and Radix Glycyrrhizae
7500~15000 grams of powder.
For another example the Chinese patent literature of Publication No. CN103349676A also discloses a kind of compound tilmicosin solubility
Pulvis, the soluble powder includes Tilmicosin and licorice.
Existing these compositions are typically only used for treatment or the auxiliary treatment of pig period of disease, cannot realize from source
The generation of the breathing problem in prevention pig growth course.And above-mentioned composition is to be played in certain stage of pig growth course
Effect, lacks systematicness, so effect is extremely limited.
The content of the invention
To solve the problems, such as prior art, the invention provides a kind of " three sections for prevention and control porcine respiratory disease
Formula " composition, it is intended to prevention and control porcine respiratory disease, improves the speed of growth and pig economic benefit of pig.
Technical scheme is as follows：
A kind of " three-stage " composition for prevention and control porcine respiratory disease, including for the composition A of weaned piglet phase；
Composition B for the child care phase and composition C for fattening period；
Wherein, described composition A includes the component of following weight portion：
0.2~0.35 part of licorice of fermentation；
0.34~0.40 part of Folium Artemisiae Argyi extract；
0.32~0.45 part of loquat-leaf extract；
0.50~1.00 part of tilmicosin phosphate preparation；
17.8~18.64 parts of zeolite powder；
Described composition B includes Echinacea Purpurea Herb P.E, the Huang of 0.38~0.52 weight portion of 0.25~0.40 weight portion
The zeolite powder of stilbene extract and 4.08~4.37 weight portions；
Described composition C include 66~70wt% corns, 17~21wt% dregs of beans, 7~11wt% wheat bran and 2~
6wt% premixes.
In the present invention, by the weaned piglet phase in the developmental process of pig, the child care phase, fattening period three respiratory tract diseases
The disease stage occurred frequently feeds corresponding particular components, the composition of proportioning respectively, by segmented feed mode of the invention and institute
The collaboration of component is stated, the risk for suffering from breathing problem from preventing on source and controlling pig growth course is capable of achieving, effectively reduced
The incidence of disease and death and culling rate, additionally, also effectively improving the speed of growth and pig economic benefit of pig.
The care plans that the present invention passes through system, three critical periods that breathing problem easily occurs in pig growth course
Composite reagent and the mixed feeds such as amino acid balance technology, low protein combination technology are taken, effectively solve porcine respiratory disease
Generation.
Preferably, described tilmicosin phosphate preparation uses coated Enteric formulations, wherein active component phosphoric acid
The content of Tilmicosin is 20~25wt%.
In instant component A, extracted by the fermentation licorice of the glycyrrhizic acid content high of the weight portion, folium artemisiae argyi
Under the scientific compatibility of the tilmicosin phosphate of thing, loquat-leaf extract and coated enteric solubility, it is possible to resolve the feeding of addition composition A
The bitter taste of material and the defect destroyed by hydrochloric acid in gastric juice, are easy to piglet to search for food, and improve the absorption rate of intestine of young pigs；So as to further assist
With raising control effect.
Preferably, in described composition A, the glycyrrhizic acid content in fermentation licorice is not less than in terms of dry product
1.1wt%.
Preferably, the volatile argyi leaf oil content in Folium Artemisiae Argyi extract in terms of dry product not less than 0.8wt%.
Preferably, the ursolic acid content in loquat-leaf extract in terms of dry product not less than 90wt%.
In the present invention, the described weaned piglet phase be wean it is preceding 5 days~wean after stage between 15 days.
The inventors discovered that, using composition A of the present invention (present invention is also referred to as glycyrrhiza compound composition) as feeding
Feed additives, added in pig complete feed, are combined to obtain piglet mixed fodder；By since before weaned piglet 5 days, continuously making
The 15th day (continuous to feed 20 days) with described piglet mixed fodder to after weaning；Prevention and control piglet is can help to feel in this period
Dye mycoplasma and the pathogen such as pig breeding and respiratory disorder synthesis virus, so that the weanling pig breathing problem incidence of disease is reduced,
Improve piglet survival ratio.
Preferably, on the basis of pig complete feed weight, described composition A is relative to the addition in pig complete feed
It is 1.5~2.5wt% to measure；More preferably 1.9~2.1wt%.
In the present invention, the method using described composition as additive added to complete feed for example can be：Will combination
After each prescription element of thing A is well mixed, it is added in complete feed for piglets in the lump；Or each component of composition A is pressed into institute
The weight ratio stated, addition are added separately to pig complete feed.
Further preferably, composition A of the present invention, pig complete feed is added to by each component：Wherein, pig per ton is complete
0.2~0.35 kilogram of fermentation licorice (glycyrrhizic acid content >=1.1%) is added in valency feed, Folium Artemisiae Argyi extract (wave by folium artemisiae argyi
Hair oil content >=0.8%) 0.34~0.40 kilogram, 0.32~0.45 kilogram of loquat-leaf extract (ursolic acid content >=90%),
Coating tilmicosin phosphate (Enteric formulations, active component content is 20%) 0.50~1.00 kilogram, zeolite powder 17.8~
18.64 kilograms.
In the present invention, the preparation method of described composition A：By described weight ratio fermentation licorice, Chinese mugwort
Leaf extract, loquat-leaf extract, tilmicosin phosphate preparation, zeolite powder are well mixed, and described composition A is obtained.
A kind of preparation method of preferred composition A is：Radix Glycyrrhizae extractive from fermentative is pressed 0.2~0.35 kg/ton first
The ratio of complete feed is added in 0.34~0.40 kg/ton of Folium Artemisiae Argyi extract of complete feed, is well mixed；Then by loquat
Leaf extract carries out honey and is made medicinal extract, is well mixed in adding said mixture according to 0.32~0.45 kg/ton of complete feed,
Mixing is equal during 0.50~1.00 kg/ton of coating tilmicosin phosphate preparation of complete feed ratio is added into preceding mixture again
It is even, during said mixture finally added into carrier zeolite powders according to 17.8~18.64 kg/ton of complete feeds, it is well mixed i.e.
Can.
Described Radix Glycyrrhizae extractive from fermentative is commercially available from existing commercial product；Or by glycyrrhiza uralensis fisch piece it is toasted, milling, plus
Bacterium fermentation, extraction and allotment are formed.
In the present invention, plus bacterium fermentation method for example by saccharomycete, Bifidobacterium, Radix Glycyrrhizae stoste in fermentation temperature 28.2
DEG C, fermentation time is extracted after 18.5 hours and obtained.
Described Folium Artemisiae Argyi extract is commercially available from Xi'an Jin Lv biotechnologies Co., Ltd, Nanjing Dao Sifu biologies section
The mechanisms such as skill Co., Ltd, Xi'an Chang Yue plants Chemical Co., Ltd..
Described loquat-leaf extract is commercially available from Nanjing Dao Sifu bio tech ltd, the bright woods biological products in Hunan
The mechanisms such as Co., Ltd, Xi'an Jin Lv biotechnologies Co., Ltd.
Tilmicosin phosphate preparation is commercially available from Suzhou Fu Lu bio tech ltd, the joyful beauty's biotechnology in Hubei
The mechanisms such as Co., Ltd, Guangzhou Shuo Mu bio tech ltd.
In the present invention, the described child care phase is 65~75 age in days stages of pig.
In the present invention, coordinate the feeding of the composition A of weaning period, then described composition B is added to pig complete feed
In, the nonspecific resistance of lifting pig body can be effectively cooperateed with, the incidence of disease is reduced, improve the speed of growth.
In described composition B (present invention is also referred to as compound Echinacea preparation), in described Echinacea Purpurea Herb P.E, with purple
Cone chrysanthemum extract dry product meter, Phenolic Compounds content is not less than 80wt%.
Preferably, in Astragalus Root P.E, in terms of Astragalus Root P.E dry product, polyoses content >=50wt%.
Preferably, the addition that described composition B adds in pig complete feed is 0.4~0.6wt%；Further
Preferably 0.45~0.55wt%.
Composition B of the present invention, each component is added to pig complete feed：Wherein, Phenolic Compounds content >=
The Echinacea Purpurea Herb P.E of 80wt% is carried by 0.25~0.40 kg/ton of complete feed addition, the Radix Astragali of polyoses content >=50wt%
Take thing to be added by 0.38~0.52 kg/ton of complete feed, 4.08~4.37 kg/ton of complete feed additions of zeolite powder.
The application process of composition B is：Composition B is added in nursery-stage pig feed according to 0.4~0.6% ratio,
Begin to use from 65 ages in days, continuous 7~10 days.
Described Echinacea Purpurea Herb P.E is commercially available from Xi'an Jin Lv biotechnologies Co., Ltd, and Nanjing Dao Sifu is biological
The mechanisms such as Science and Technology Ltd., Xi'an Chang Yue plants Chemical Co., Ltd..
Described Astragalus Root P.E is commercially available from Xi'an Jin Lv biotechnologies Co., Ltd, Nanjing Dao Sifu biologies section
The mechanisms such as skill Co., Ltd, Xi'an Chang Yue plants Chemical Co., Ltd., Changsha Naturalin Bio-resources Co., Ltd..
In the present invention, described composition B is used as feed addictive；Composition B is added to the method in feed
For example can be：Described Echinacea Purpurea Herb P.E and Astragalus Root P.E are mixed by the well mixed rear and complete feed of the weight part ratio
Close；Or by described weight portion, when addition is added separately in complete feed by each component in composition B.
In the present invention, described fattening period refers to stage of the pig age more than or equal to 76 ages in days.
Further preferably, described composition C, including 68wt% corns, 19wt% dregs of beans, 9wt% wheat bran and 4wt% are pre-
Batch mixing.
In the present invention；Described premix comprising lysine, methionine, phytase, nicotinic acid, ethoxyquinoline, allicin,
Choline Chloride, multivitamin, salt, calcium monohydrogen phosphate, stone flour, oil powder and several mineral materials.
Preferably, in premix per ton, comprising 46~50kg/T of lysine, 10~14kg/T of methionine, phytase 3~
7kg/T, 1.0~1.4kg/T of nicotinic acid, 0.5~1.5kg/T of ethoxyquinoline, 2~4kg/T of allicin, Choline Chloride 16~
20kg/T, 6~8kg/T of multivitamin, 73~77kg/T of salt, 125~135kg/T of calcium monohydrogen phosphate, 380~400kg/ of stone flour
T, 210~230kg/T of oil powder, 89~94kg/T of growing and fattening pigs several mineral materials.
A kind of present invention, special premix, premix per ton includes lysine 48kg, methionine 12kg, phytase
5kg, nicotinic acid 1.2kg, ethoxyquinoline 1kg, allicin 3kg, Choline Chloride (Choline Chloride active component content is 50%)
18kg, multidimensional 7kg, salt 75kg, calcium monohydrogen phosphate 128kg, stone flour 390kg, oil powder 220kg, growing and fattening pigs several mineral materials
91.8kg。
In the present invention, described composition C is used as feed by the application process of described composition C, live pig 76~
180 age in days phase feedings.
In the present invention, coordinate the feeding of the composition A and the composition B of child care phase of weaning period of the present invention, then match somebody with somebody
The accurate nutrient formulation feed closed in fattening period is raised, and is effectively reduced the noxious gas emissions such as ammonia, hydrogen sulfide, is reduced pig and is exhaled
The incidence of disease of tract disease is inhaled, the speed of growth is improved.
In the present invention, in described composition A, licorice is the composition for having medical value extracted from Radix Glycyrrhizae,
Glycyrrhizin, glycyrrhizic acid, liquiritin, flavonoids of Glycyrrhiza, rear and Quercetin etc. are generally comprised, has been yellow to brownish-yellow powder.
Folium Artemisiae Argyi extract is that, with water-ethanol as Extraction solvent, heating and refluxing extraction is concentrated and powdered thing.Folium Artemisiae Argyi extract contains terpene
Product enol -4, β-carypohyllene, artemisol, linalool, camphor, borneol, cineole and phellandrene etc. are containing the mixing based on volatile oil
Thing.Loquat-leaf extract principal component is the volatile oil such as nerolidol and fanesol, also α and beta pinene, amphene, laurene, right
P-cymene, linalool, ylangene, α and β farnesenes, camphor, nerol, Geraniol, α-pilgerol, elemol,
Cis- beta, gamma-hexenol and linalool oxide and amygdalin, ursolic acid, oleanolic acid, tartaric acid, citric acid, malic acid,
Tannin, vitamin B and C etc..Coating tilmicosin phosphate is to be coated with tilmicosin phosphate with crude granule and outer coatings etc. to form,
To reduce its bitter taste, in order to searching for food and absorbing, its drug effect is given full play to.
In composition A, by the licorice of the weight, Folium Artemisiae Argyi extract, loquat-leaf extract and boiling
The mutual collaboration of stone；It is clearing heat and detoxicating with invigorating the spleen and benefiting qi, expelling phlegm and arresting coughing, to relieving asthma, enhancing is immune, protect liver cholagogic, activating complement etc.
Function, can improve piglet spleen and stomach function, the body drag of lifting piglet.Described composition A is added in pig starter feed, can be effective
The breathing problem incidence of disease of the prevention and control piglet in this period, improves piglet survival ratio and fitness.
In composition B, Echinacea Purpurea Herb P.E：For the cauline leaf of feverfew Echinacea Echinacea Purpurea, root are carried
Thing is taken, is yellowish-brown powder；Active ingredient is amide-type, Polyphenols, caffeic acid ester derivants, flavonoids and volatile oil etc.,
Its specification is that based on dry product, total phenol content is not less than 4.0%.In Astragalus Root P.E：Astragalus polyose is that legume Mongolia is yellow
The dry root of stilbene or Astragalus membranacus is extracted, concentration, the water-soluble heteroglycan of purifying, by hexuronic acid, glucose, fruit
Sugar, rhamnose, arabinose, galacturonic acid and glucuronic acid etc. are constituted.Extracted by the Echinacea of the weight part ratio
Using cooperatively for thing and Astragalus Root P.E, can cooperate with the non-specific and specific immune function of the resistance of enhancing child care phase pig,
There is good antiviral, antimycotic, antitumor and desinsection, the resistance of anti-inflammatory so as to child care phase pig can be made.
In the present invention, a kind of application of described " three-stage " composition is additionally provided, described composition is used to make
The feed addictive or feed of standby prevention and control porcine respiratory syndrome.
In the present invention, in described application, using composition A as feed addictive added to 5 days before weaned piglet to disconnected
In the pig complete feed fed between the 15th day after milk, wherein, composition A is with respect to the percentage by weight of pig complete feed
1.5~2.5wt%；Using composition B as feed addictive added to the pig complete feed fed between 65~75 ages in days, its
In, composition B is 0.4~0.6wt% with respect to the percentage by weight of pig complete feed；Composition C is used as between 76~180 ages in days
The feed of feeding.
In the present invention, the pig full price for being added with composition A is fed between the 15th day from before weaned piglet after 5 days to wean
Feed, wherein composition A are 1.5~2.5wt% with respect to the percentage by weight of pig complete feed；Fed between 65~75 ages in days and added
Added with the pig complete feed of composition B, wherein, composition B is 0.4~0.6wt% with respect to the percentage by weight of pig complete feed；
Feed composition C between 76~180 ages in days.
In described application, described pig complete feed is the full nutrient fodder for being not added with composition of the present invention；
Buyable is to existing commercial feed.
Beneficial effect
By the composition A of described weaned piglet phase；For the composition B and the composition for fattening period of child care phase
The regulation and control of the three-stage of C (being used as feed), can effectively cooperate with the breathing problem in prevention and control pig growth course, can effectively do sth. in advance pig
Deliver for sale, save feed, increase economic efficiency.
1st, sharpest edges of the invention are occurrence regularities originally according to live pig breathing problem, in three stages and coupling
Close each special composition described in cooperate with the generation of prevention and control porcine respiratory disease, can effectively reduce breathing problem
The incidence of disease and dead residual rate.The present invention using the feeding of system, regulation and control, realizes the prevention and control of porcine respiratory disease first.
2nd, in the present invention, during control porcine respiratory disease occurs, two groups of different Chinese herbal medicine formulas have been used
Composition (composition A and composition B are used as feed addictive) and a scientific and reasonable feed formula (composition C).This hair
It is bright middle according to pig growth characteristics, using each Chinese herbal medicine and active component that integrally, systematically feed described scientific compatibility；It is reachable
To the effect treated both principal and secondary aspect of disease；Focus on preventing the generation of breathing problem.
3rd, product of the present invention uses the fermentation of Chinese herbal medicine active ingredient with unique function and special anti-breathing for the first time
The tilmicosin phosphate of tract disease is formed through scientific compatibility, with environmental protection, determined curative effect and is not likely to produce drug resistance and not
The features such as easily recurring.
Specific embodiment
Following examples, unless specified or limited otherwise, using following raw material：
Described Radix Glycyrrhizae extractive from fermentative is commercially available from existing commercial product, or by medicinal material licorice tablet, toasted, mill
Powder, plus bacterium fermentation, extract form.
In terms of Radix Glycyrrhizae extractive from fermentative dry product, glycyrrhizic acid content >=1.1wt%；
Enteric solubility is coated with tilmicosin phosphate preparation：Suzhou Fu Lu bio tech ltd.Active component phosphoric acid replaces rice
The content for examining star is 20wt%.
Folium Artemisiae Argyi extract is bought from Xi'an Jin Lv biotechnologies Co., Ltd；Wherein, the folium artemisiae argyi in Folium Artemisiae Argyi extract
Volatile oil content is calculated as 0.9wt% with dry product.
Loquat-leaf extract is bought from Xi'an Jin Lv biotechnologies Co., Ltd；Ursolic acid in loquat-leaf extract
Content is calculated as 90wt% with dry product.
Astragalus Root P.E is bought from Xi'an Jin Lv biotechnologies Co., Ltd.In Astragalus Root P.E, with astragalus extraction
Thing dry product meter, polyoses content is 52wt%.
Echinacea Purpurea Herb P.E buys Anchang high mountain plant Chemical Co., Ltd. westerly.It is purple in terms of Echinacea Purpurea Herb P.E dry product
Cone chrysanthemum polyphenol content is 80wt%.
Described special premix, premix per ton includes lysine 48kg, methionine 12kg, phytase 5kg, nicotinic acid
1.2kg, ethoxyquinoline 1kg, allicin 3kg, Choline Chloride (50%) 18kg, multidimensional 7kg, salt 75kg, calcium monohydrogen phosphate
128kg, stone flour 390kg, oil powder 220kg, growing and fattening pigs several mineral materials 91.8kg.
Embodiment 1
First, health care prevention and control basic condition
In March, 2015, the piglet before the 82 nests wean of self-employed pig raiser family of Liuyang City of Hunan Province, point 4 groups, first
Group 26 sow litters 273 of random selection, porcine respiratory disease is controlled according to the inventive method in three stages：I.e. first
Stage is for 15 days after first 5 days~wean of weaning, 20 ages in days start to add " glycyrrhiza compound group according to 2.0% ratio after birth
Compound " (composition A) feeds in piglet normal diet, and 25 ages in days start wean, then proceedes to be fed to disconnected using former scheme
It is the 15th day after milk, continuous altogether to use 20 days；Second stage is to add 0.5% in normal diet since 65 ages in days
" compound Echinacea composition " (composition B) is continuous to use 10 days in nursery-stage pig feed；Phase III since 76 ages in days,
Using corn 68%, dregs of beans 19%, wheat bran 9% and 4% special premix (composition C) precisely nutrient formulation feed, feeding
Delivered for sale to 180 ages in days.
In the present embodiment, " glycyrrhiza compound composition " is added in pig starter feed, wherein, fermentation licorice is (sweet
Oxalic acid content >=1.1%) 0.3 kg/ton of pig starter feed, 0.35 kg/ton of pig starter feed of Folium Artemisiae Argyi extract, loquat-leaf extract
0.4 kg/ton of pig starter feed, is coated with tilmicosin phosphate (Enteric formulations, 20% content) 1.00 kg/ton of pig starter feeds,
18.00 kg/ton of pig starter feeds of zeolite powder.
By the compound Echinacea composition added in nursery-stage pig feed, wherein, Echinacea Purpurea Herb P.E by 0.3 kilogram/
Ton nursery-stage pig feed, 0.42 kg/ton of nursery-stage pig feed of Astragalus Root P.E, 4.20 kg/ton of nursery-stage pig feeds of zeolite powder.
Following contrast experiment's group, feeding manner and first group it is identical, differ only in, be not added with the feed of raising described
Composition A and/or B；And/or use common fattening feed substitute composition C：
Second group (contrast groups 1) randomly select 26 sow litters 275, in weaning period (first 5 days-wean of weaning
15 days afterwards) and the child care phase (65-75 days) do not use composition A, B of the invention, only in fattening period (76-180 days) using combining
Thing C, other periods raise normal diet and (that is to say, compared with first group, difference is that the feed of weaning period feeding is not added with
Described composition A, the feed of child care phase feeding is not added with described composition B).
3rd group (contrast groups 2) randomly select 15 sow litters 147, only (wean first 5 days-disconnected in weaning period
15 days after milk) feed that is added with composition A of the use as described in first group, other periods raising normal diet (that is to say, and
First group is compared, and difference is that the feed of child care phase feeding is not added with described composition B；Fattening period selects conventional feed).
4th group (contrast groups 3) randomly select 15 sow litters 152, in weaning period (first 5 days-wean of weaning
15 days afterwards) using the feed for being added with composition A as described in first group, (65-75 days) child care phase is using as described in first group
The feed for being added with composition B, other periods raise normal diet (that is to say, compared with first group, difference is to fatten
Phase selects conventional feed).
2nd, health care control effect
There is slight symptoms of respiratory disease in feeding process using first group of the invention only 7 pigs, 3 is first-born
Length has slowed down without the appearance of dead and cad pig, and the incidence of disease is 3.66%, and dead residual rate is 0；And only use second group of composition C
What pig occurred breathing problem has 69, dead 2, cad pig 6, and the incidence of disease is 25.09%, and dead residual rate is 2.90%；The
What three groups of pigs occurred breathing problem has 27, dead 2, produces cad pig 1, and the incidence of disease is 18.37%, and dead residual rate is
2.04%；What the 4th group of pig occurred breathing problem has 17, dead 1, produces cad pig 1, and the incidence of disease is 11.18%,
Dead residual rate is 1.32%.
Using first group of pig of the invention relative to best the 4th group, every 5.2 kilograms of average weight gain is delivered for sale ahead of time
8 days, every average 18.9 kilograms of feed of saving, daily live pig produced 38.7 yuan of direct economic benefit.
Embodiment 2
First, health care prevention and control basic condition
2 months in 2016, the piglet before the 78 nests wean of Huaihua City self-employed pig raiser family of Hunan Province, point 4 groups, first
Group 19 sow litters 207 of random selection, take " three-stage " care plans of the invention to carry out health care prevention and control, i.e., and the
One stage started to be added " glycyrrhiza compound composition A " to feeding in complete feed for piglets according to 1.9% ratio after birth for 20 days
Hello, start within 25 days wean, then proceed to the 15th day using former scheme to after weaning；Second segment is since 65 ages in days in feed
" the compound Echinacea composition B " of addition 0.53% is continuous to use 10 days in nursery-stage pig feed；Phase III opens from 76 ages in days
Begin, raised using the accurate nutrient formulation feed of special premix (composition C) of corn 68%, dregs of beans 19%, wheat bran 9% and 4%
170 ages in days are fed to, other feeding manners are identical with other groups.
In the present embodiment, " glycyrrhiza compound composition " is added in pig starter feed, wherein, fermentation licorice is (sweet
Oxalic acid content >=1.1%) 0.2 kg/ton of pig starter feed, 0.34 kg/ton of pig starter feed of Folium Artemisiae Argyi extract, loquat-leaf extract
0.32 kg/ton of pig starter feed, is coated with tilmicosin phosphate (Enteric formulations, 20% content) 0.50 kg/ton of pig starter feed,
18 kg/ton of pig starter feeds of zeolite powder.
By the compound Echinacea composition added in nursery-stage pig feed, wherein, Echinacea Purpurea Herb P.E by 0.32 kilogram/
Ton nursery-stage pig feed, 0.45 kg/ton of nursery-stage pig feed of Astragalus Root P.E, 4.53 kg/ton of nursery-stage pig feeds of zeolite powder.
Following contrast experiment's group, feeding manner and first group it is identical, differ only in, be not added with the feed of raising described
Composition A and/or B；And/or use common fattening feed substitute composition C：
Second group (contrast groups 1) randomly select 19 sow litters 205, and composition A, B and C are not used, take
Conventinal breeding mode is raised, and (be that is to say, is compared with first group, difference is that the feed of weaning period feeding is not added with described group
Compound A；The feed of child care phase feeding is not added with described composition B；Fattening period selects conventional feed).
3rd group (contrast groups 2) randomly select 20 sow litters 211, and first group of difference is, and first
Only lack the coated tilmicosin phosphate of the weight portion in the composition A of phase feeding, other feeding manners are with first group.
4th group (contrast groups 1) randomly select 20 sow litters 208, are taken " three stages " by mode of the present invention
Mode prevention and control are raised, and are compared with first group, and difference is that composition A is only coated tilmicosin phosphate, other feeding manners
With first group.
2nd, health care control effect
Using first group of pig of the invention, only 3 have slight symptoms of respiratory disease in feeding process, and 2 is first-born
Length has slowed down, and the incidence of disease is 2.42%, and dead residual rate is 0.Without there is respiratory tract disease using second group of pig of the invention
Sick has 73, and the incidence of disease is 35.61%；Death, produces cad pig 1 by 3, and dead residual rate is 2.44%.Do not add in composition A
Plus the 3rd group of coated tilmicosin phosphate, what breathing problem occurred has 43, and the incidence of disease is 20.38%；Dead 2,
Cad pig 2, dead residual rate is 1.90%., there is respiratory tract disease in the 4th group that coated tilmicosin phosphate is only added in composition A
Sick has 45, and the incidence of disease is 21.63%；Dead 1, cad pig 6, dead residual rate is 3.37%.
Claims (10)
1. a kind of " three-stage " composition for prevention and control porcine respiratory disease, it is characterised in that including for the weaned piglet phase
Composition A；Composition B for the child care phase and composition C for fattening period；
Wherein, described composition A includes the component of following weight portion：
0.2~0.35 part of licorice of fermentation；
0.34~0.40 part of Folium Artemisiae Argyi extract；
0.32~0.45 part of loquat-leaf extract；
0.50~1.00 part of tilmicosin phosphate preparation；
17.8~18.64 parts of zeolite powder；
Described composition B includes that the Echinacea Purpurea Herb P.E of 0.25~0.40 weight portion, the Radix Astragali of 0.38~0.52 weight portion are carried
Take the zeolite powder of thing and 4.08~4.37 weight portions；
Described composition C includes that 66~70wt% corns, 17~21wt% dregs of beans, 7~11wt% wheat bran and 2~6wt% are pre-
Batch mixing.
2. " three-stage " composition of prevention and control porcine respiratory disease is used for as claimed in claim 1, it is characterised in that described
In composition A, the glycyrrhizic acid content in fermentation licorice is in terms of dry product not less than 1.1wt%；
Volatile argyi leaf oil content in Folium Artemisiae Argyi extract is in terms of dry product not less than 0.8wt%；
Ursolic acid content in loquat-leaf extract is in terms of dry product not less than 90wt%.
3. " three-stage " composition of prevention and control porcine respiratory disease is used for as claimed in claim 2, it is characterised in that described
Tilmicosin phosphate preparation use coated Enteric formulations, wherein the content of active component tilmicosin phosphate be 20~
25wt%.
4. " three-stage " composition for prevention and control porcine respiratory disease as described in any one of claims 1 to 3, its feature exists
In, in described composition B, in described Echinacea Purpurea Herb P.E, in terms of Echinacea Purpurea Herb P.E dry product, Phenolic Compounds content
Not less than 80wt%；
In Astragalus Root P.E, in terms of Astragalus Root P.E dry product, polyoses content >=50wt%.
5. " three-stage " composition for prevention and control porcine respiratory disease as described in any one of Claims 1 to 4, its feature exists
Lysine, methionine, phytase, nicotinic acid, ethoxyquinoline, allicin, Choline Chloride, various is included in, described premix
Vitamin, salt, calcium monohydrogen phosphate, stone flour, oil powder and several mineral materials.
6. " three-stage " composition of prevention and control porcine respiratory disease is used for as claimed in claim 5, it is characterised in that per ton pre-
In batch mixing, comprising 46~50kg/T of lysine, 10~14kg/T of methionine, 3~7kg/T of phytase, 1.0~1.4kg/T of nicotinic acid,
0.5~1.5kg/T of ethoxyquinoline, 2~4kg/T of allicin, 16~20kg/T of Choline Chloride, 6~8kg/T of multivitamin,
73~77kg/T of salt, 125~135kg/T of calcium monohydrogen phosphate, 380~400kg/T of stone flour, 210~230kg/T of oil powder, fatten
89~94kg/T of pig several mineral materials.
7. " three-stage " composition of prevention and control porcine respiratory disease is used for as claimed in claim 6, it is characterised in that described
Composition C, including 68wt% corns, 19wt% dregs of beans, 9wt% wheat bran and 4wt% premixes.
8. " three-stage " composition of prevention and control porcine respiratory disease is used for as claimed in claim 1, it is characterised in that described
The weaned piglet phase be wean it is preceding 5 days~wean after stage between 15 days；The child care phase is 65~75 age in days stages of pig；Described
Fattening period refers to stage of the pig age more than or equal to 76 ages in days.
9. the application of " three-stage " composition as described in any one of claim 1~8, it is characterised in that by described combination
Thing is used to prepare the feed addictive or feed of prevention and control porcine respiratory syndrome.
10. the application of " three-stage " composition as claimed in claim 9, it is characterised in that added composition A as feed
Agent added in the pig complete feed fed between the 15th day to after weaning for 5 days before weaned piglet, wherein, composition A is relative
The percentage by weight of pig complete feed is 1.5~2.5wt%；65~75 ages in days are added to using composition B as feed addictive
Between feed pig complete feed, wherein, composition B with respect to pig complete feed percentage by weight be 0.4~0.6wt%；Group
Compound C is used as the feed fed between 76~180 ages in days.
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| CN113163803A (en) * | 2018-11-20 | 2021-07-23 | 纽崔克Ip资产有限公司 | Composition for feeding pregnant animals |
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