CN104784530B - A kind of Chinese medical extract of blood pressure lowering and preparation method thereof - Google Patents
A kind of Chinese medical extract of blood pressure lowering and preparation method thereof Download PDFInfo
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- CN104784530B CN104784530B CN201510164645.3A CN201510164645A CN104784530B CN 104784530 B CN104784530 B CN 104784530B CN 201510164645 A CN201510164645 A CN 201510164645A CN 104784530 B CN104784530 B CN 104784530B
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Abstract
The invention discloses a kind of Chinese medical extract of blood pressure lowering and preparation method thereof, which is prepared by the traditional Chinese medicinal material raw materials of following parts by weight：31 42 parts of the fruit of Cherokee rose, 55 68 parts of oenothera biennis, 6 11 parts of field thistle, 17 30 parts of corn stigma.The present invention is used for that blood pressure lowering to be quick, good effect, and administration can take effect and evident in efficacy after three days, and not occur obvious adverse reaction during patient takes medicine.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, and in particular to a kind of Chinese medical extract of blood pressure lowering and preparation method thereof.
Background technology
Hypertension is the clinical syndrome increased with systemic arterial pressure mainly to show, is most common cardiovascular disease
Disease.Hypertension can be divided into two major class of primary and Secondary cases.In most patients, the etiology unknown of hypertension, is referred to as
Essential hypertension, accounts for more than the 95% of total hyperpietic；In less than 5% patient, blood pressure rise is one kind of some diseases
Clinical manifestation, itself there is the clear and definite and independent cause of disease, is known as secondary hypertension.Essential hypertension, also known as high blood pressure, lead to
Normal onset is slow, often asymptomatic in early days, feels good and even discovery blood pressure rise when physical examination for many years, and small number of patients then exists
It can be just found after the complication such as the generation heart, brain, kidney.
Hypertension incidence is high, can induce the generation of the diseases such as coronary heart disease, cerebral hemorrhage, and most of causes the heart, brain, kidney
A series of damages and serious lesion, even functional failure Deng vitals, and sugar, hawk matter metabolic disorder, to people
Health cause very big threat.According to statistics, whole world Prevalence of Hypertension is up to 10%-20%, suffers from the people of hypertension
Number has reached 1,000,000,000, and various diseases caused by hypertension are died of per year over ten thousand people of l200.Population of China Prevalence of Hypertension
It is in rising trend, national hypertension investigation display three times.The incidence of l959 is 5.11%.L979-1980 annual morbidities
It is 11.26% for 7.73%, l990-1991 annual morbidities, the existing hyperpietic in China alreadys exceed l.2 hundred million people, and
Every year still with the speed increase of more than 600 ten thousand people.According to the prediction of World Health Organization, to 2020, non-communicable diseases will account for me
The 79% of state's cause of death.The wherein angiocardiopathy such as hypertension is by account for the first.Therefore, prevention and treatment high blood pressure has become
The hot spot of today's society research；It is one of significant problem urgently to be resolved hurrily at present.
Hypertension be it is a kind of need long-term monitoring and treatment chronic disease, it is necessary to take medicine throughout one's life.Existing hypotensor
Thing is usually Western medicine, and Long-term taking medicine can have larger side effect to the liver of human body, kidney etc., and easily trigger cough, edema, dizziness etc. no
Suitable reaction.Therefore, it is necessary to find a kind of effective hypotensor to body Small side effects, cheap.
The content of the invention
It is an object of the invention to pass through the further investigation and improvement to folk remedy, there is provided a kind of Chinese medicine of blood pressure lowering
Extract and preparation method thereof.
The object of the present invention is achieved like this：
A kind of Chinese medical extract of blood pressure lowering, the Chinese medical extract are prepared by the traditional Chinese medicinal material raw materials of following parts by weight：
31-42 parts of the fruit of Cherokee rose, 55-68 parts of oenothera biennis, 6-11 parts of field thistle, 17-30 parts of corn stigma.
Preferably, the Chinese medical extract of above-mentioned blood pressure lowering, it is prepared by the traditional Chinese medicinal material raw materials of following parts by weight：Jin Ying
35-37 parts sub-, 58-62 parts of oenothera biennis, 7-9 parts of field thistle, 21-25 parts of corn stigma.
In the most preferred embodiment of the present invention, the Chinese medical extract of above-mentioned blood pressure lowering is by following parts by weight
Medicinal raw material is prepared：36 parts of the fruit of Cherokee rose, 60 parts of oenothera biennis, 8 parts of field thistle, 23 parts of corn stigma.
Still further preferably, the Chinese medical extract of the blood pressure lowering is oral formulations, including oral liquid, granule,
Tablets and capsules.It can be pressed by traditional Chinese medicinal material raw materials after alcohol extracting and decocting extraction are prepared into Chinese medical extract and add auxiliary material
Oral liquid, granule, tablet or capsule are prepared into according to the common process of this area.
Traditional Chinese medicinal material raw materials of the present invention have following source：The fruit of Cherokee rose selects rosaceous plant fruit of Cherokee rose Rosa
The dry mature fruit of laevigata Michx..Oenothera biennis selects onagraceae plant oenothera biennis Oenothera biennis
L. root.Field thistle selects composite family field thistle platymiscium field thistle Cephalanoplos segetum (Bunge) Kitam.
The wounded in the battle dry aerial parts of [Cirsium segetum Bunge].Corn stigma selects grass family Zea plant Zea mays Zea
The style and fresh idea of mays L..
In addition, present invention also offers a kind of preparation method of the Chinese medical extract of above-mentioned blood pressure lowering, this method is included such as
Lower step：
(1) oenothera biennis is weighed, the alcohol reflux that 90% (preferably 95%) is more than with volumetric concentration extracts 1-3 times, each 1-
2h, filtration, filter residue is spare, and gained filtrate dry, pulverize through the recycling ethanol that is concentrated under reduced pressure, obtain oenothera biennis alcohol-extracted extract powder；
(2) filter residue obtained by step (1) and remaining medicinal material are merged, adds 8-16 times of water boiling and extraction 1-3 times, each 1-
3h, filtration, gained filtrate dry, pulverize through being concentrated under reduced pressure, obtain the water extracted immersing paste powder；
(3) oenothera biennis alcohol-extracted extract powder obtained by step (1) and the water extracted immersing paste powder obtained by step (2) are mixed, obtains Chinese medicine and carry
Take thing.
Compared with prior art, the invention has the advantages that and significantly improving：(1) good effect.The Chinese medicine of the present invention
Extract is used for that blood pressure lowering to be quick, good effect, and administration can take effect and evident in efficacy after three days.(2) it is safe.Due to this
The medicine of invention is prepared using traditional Chinese medicine, and toxicity and adverse reaction are low, and patient does not occur obvious bad during taking medicine
Reaction.
Brief description of the drawings
Fig. 1 blood pressure trend curve figure, wherein abscissa after the 0th, 1,3,5,8,12,16,22 administration 1h for each group
For administration time (d), ordinate is rat systolic pressure (mmHg).
Embodiment
The present invention is further illustrated below by preparation embodiment and clinical practice example.The following embodiments of the present invention and dynamic
Thing test example is only used for explaining technical scheme and technique effect, rather than limitation of the present invention, in this hair
The scope of protection of present invention is belonged to the simple modifications of prescription of the present invention and preparation method under bright concept thereof.
Embodiment 1：The preparation of extract dry powder
(1) oenothera biennis 6.0kg is weighed, is crushed, is extracted 2 times, each 1h with the alcohol reflux that 60L volumetric concentrations are 95%,
Filtration, filter residue is spare, and gained filtrate is concentrated under reduced pressure under the pressure of 0.08MPa recycles ethanol, and continues to be concentrated into thick paste, does
It is dry, 100 mesh sieves are crushed, obtain oenothera biennis alcohol-extracted extract powder；
(2) fruit of Cherokee rose 3.6kg, field thistle 0.8kg, corn stigma 2.3kg are weighed, is merged, is crushed, adds filter obtained by step (1)
Slag, adds water to cook twice, and first time plus water are 15 times of amounts of medicinal material gross weight, decoct 2h, for the second time plus water is medicinal material gross weight
12 times amount, decoct 1.5h, collecting decoction, thick paste is concentrated under reduced pressure under the pressure of 0.08MPa, dry, pulverize 100 mesh
Sieve, obtains the water extracted immersing paste powder；
(3) oenothera biennis alcohol-extracted extract powder obtained by step (1) and the water extracted immersing paste powder obtained by step (2) are mixed, obtains extract
Dry powder.
Embodiment 2：The preparation of extract dry powder
(1) oenothera biennis 6.5kg is weighed, is crushed, is extracted 2 times, each 1h with the alcohol reflux that 65L volumetric concentrations are 95%,
Filtration, filter residue is spare, and gained filtrate is concentrated under reduced pressure under the pressure of 0.08MPa recycles ethanol, and continues to be concentrated into thick paste, does
It is dry, 100 mesh sieves are crushed, obtain oenothera biennis alcohol-extracted extract powder；
(2) fruit of Cherokee rose 4.0kg, field thistle 1.0kg, corn stigma 2.0kg are weighed, is merged, is crushed, adds filter obtained by step (1)
Slag, adds water to cook twice, and first time plus water are 15 times of amounts of medicinal material gross weight, decoct 2h, for the second time plus water is medicinal material gross weight
12 times amount, decoct 1.5h, collecting decoction, thick paste is concentrated under reduced pressure under the pressure of 0.08MPa, dry, pulverize 100 mesh
Sieve, obtains the water extracted immersing paste powder；
(3) oenothera biennis alcohol-extracted extract powder obtained by step (1) and the water extracted immersing paste powder obtained by step (2) are mixed, obtains extract
Dry powder.
Embodiment 3：Influence experimental study of the Chinese medical extract to spontaneous hypertensive rat systolic pressure
Spontaneous hypertensive rat (SHR) 40,9 week old, half male and half female, SPF grades, 240~300g of weight.Adaptability is raised
Support after a week, be randomly divided into four groups, be respectively blank control group, extract low dose group, extract high dose group, positive control
Group, then by 2mL/200g medicine liquid volume gastric infusions.On the basis of animal body quality, extract is low, high dose group fills respectively
Stomach gives Chinese medical extract (being prepared by the formulation and technology of embodiment 1) 82.7,248.1mg/kg, and positive controls gavage gives card
Top profit 2.25mg/kg, blank control group gavage give the physiological saline of respective volume.Each group is in the 1st, 3,5,8,12,16,22
With BP-6 animal non-invasive blood pressure analyzers (Chengdu TME Technology Co., Ltd.) measurement blood pressure after its gavage 1h.Environment quiet, perseverance
Warm (26 DEG C), in clear-headed and non-measurement rat systolic pressure under enraging state, continuously measurement 3 times, take average.The results show that blank
Control group SHR rat blood pressures are constantly raised with the time, illustrate that 11 week old SHR Hypertension Rats are gradually forming, and with when
Between extension, hypertension degree gradually aggravates；From the 3rd day, Captopril group, Chinese medical extract high and low dose group and blank
Group substantially reduces (P ＜ 0.05) compared to blood pressure, referring to Fig. 1.
Claims (4)
1. a kind of preparation method of the Chinese medical extract of blood pressure lowering, it is characterised in that the Chinese medical extract is by following weight
The traditional Chinese medicinal material raw materials of part are prepared：31-42 parts of the fruit of Cherokee rose, 55-68 parts of oenothera biennis, 6-11 parts of field thistle, 17-30 parts of corn stigma；
Method includes the following steps：
(1) oenothera biennis is weighed, 90% ethanol solution refluxing extraction 1-3 times, each 1-2h is more than with volumetric concentration, is filtered, filter
Slag is spare, and gained filtrate dry, pulverize through the recycling ethanol that is concentrated under reduced pressure, obtain oenothera biennis alcohol-extracted extract powder；
(2) filter residue obtained by step (1) and remaining medicinal material are merged, adds 8-16 times of water boiling and extraction 1-3 times, each 1-3h, filtered
Cross, gained filtrate dry, pulverize through being concentrated under reduced pressure, obtain the water extracted immersing paste powder；
(3) oenothera biennis alcohol-extracted extract powder obtained by step (1) and the water extracted immersing paste powder obtained by step (2) are mixed, obtains Chinese medical extract.
2. preparation method according to claim 1, it is characterised in that the Chinese medical extract by following parts by weight Chinese medicine
Material raw material is prepared：35-37 parts of the fruit of Cherokee rose, 58-62 parts of oenothera biennis, 7-9 parts of field thistle, 21-25 parts of corn stigma.
3. preparation method according to claim 1, it is characterised in that the Chinese medical extract by following parts by weight Chinese medicine
Material raw material is prepared：36 parts of the fruit of Cherokee rose, 60 parts of oenothera biennis, 8 parts of field thistle, 23 parts of corn stigma.
4. preparation method according to claim 1, it is characterised in that the volume fraction of the ethanol solution described in step (1)
For 95%.
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| CN201510164645.3A CN104784530B (en) | 2015-04-09 | 2015-04-09 | A kind of Chinese medical extract of blood pressure lowering and preparation method thereof |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101507494A (en) * | 2009-02-12 | 2009-08-19 | 刘志伟 | Special diet food for patient with hyperlipidemia and hypertension |
| CN104107349A (en) * | 2014-07-01 | 2014-10-22 | 河南科技大学第一附属医院 | Chinese herbal medicine for three-hypers patients, and its administration method |
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2015
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101507494A (en) * | 2009-02-12 | 2009-08-19 | 刘志伟 | Special diet food for patient with hyperlipidemia and hypertension |
| CN104107349A (en) * | 2014-07-01 | 2014-10-22 | 河南科技大学第一附属医院 | Chinese herbal medicine for three-hypers patients, and its administration method |
Non-Patent Citations (1)
| Title |
|---|
| γ-月见草-E胶丸治疗原发性高血压病36例;宦鹏年;《上海预防医学杂志》;19920930(第9期);第20页 * |
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