CN106619239A - Red algae extract-containing composition and application thereof - Google Patents
Red algae extract-containing composition and application thereof Download PDFInfo
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- CN106619239A CN106619239A CN201611166925.9A CN201611166925A CN106619239A CN 106619239 A CN106619239 A CN 106619239A CN 201611166925 A CN201611166925 A CN 201611166925A CN 106619239 A CN106619239 A CN 106619239A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/02—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings containing insect repellants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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Abstract
The invention discloses a red algae extract-containing composition and application thereof, aiming at providing a red algae extract-containing composition which is reasonable in compatibility of medicines, has a synergistic effect and has multiple effects of improving the skin barrier function, moisturizing, resisting free radicals and aging, and the like. The composition is mainly prepared from the following components in parts by weight: 5-30 parts of a red algae extract, 1-10 parts of a florentina root extract and 5-15 parts of a blackberry leaf extract. The red algae extract-containing composition belongs to the field of cosmetics.
Description
Technical field
The invention discloses a kind of composition, is a kind of composition containing red algae extract specifically；The present invention also public affairs
The application of said composition is opened, has belonged to cosmetic field.
Background technology
In recent years, the skin care item of efficiency natural increasingly obtain the accreditation of consumer, and wherein marine natural product is for people
The validity of class skin has obtained the accreditation of authoritative institution of the world, and many scientific achievements have been widely used for cosmetics neck
Domain.Compared with traditional plant or artificial biochemical cosmetic composition, marine natural product is not only natural, efficient, and is more suitable for
Percutaneous absorption.
At present, non-algae most widely used in marine natural product does not belong to.Seaweed growth is in high salt, high pressure, low temperature, low
In the extremely complex Seawater of nutrition, no light and chemical constituent, its ecological environment, metabolite and metabolic characteristic and land
Plant has larger difference, embodies a concentrated reflection of body and is contained within the special biological active matter of structure and metabolite.Contain in red algae
Abundant carbohydrate, protein, lipid, trace element, mineral matter, vitamin etc., this kind of biological active matter can be applicable to
In new type functional cosmetics, there is larger potentiality to be exploited.
The present invention is acted synergistically by Multiple components, effectively supplements skin moisture, makes skin keep permanent moist, increases skin
Skin elasticity, improves skin sub-health status, strengthens the resistance of skin.
The content of the invention
For the problems referred to above, the first object of the present invention is to provide a kind of compatibility rationally, Synergistic, with enhancing skin
The composition containing red algae extract of barrier function and moisturizing water lock, Green Tea Extract and anti-ageing multiple efficacies of waiting for a long time.
The second object of the present invention is to provide this composition containing red algae extract in answering as skin-care product additive
With.
To solve first technical problem, first technical scheme that the present invention is provided is such：
A kind of composition containing red algae extract, is mainly made up of the component of following weight portion：Red algae extract 5-30 parts,
Pale flag root extract 1-10 parts, blackberry, blueberry leaf extract 5-15 parts.
Further, above-mentioned a kind of composition containing red algae extract, also including cotton extract 3-10 parts, English walnut seed
Extract 1-6 parts, Withania kansuensis root extract 1-5 parts.
Further, a kind of above-mentioned composition containing red algae extract, the red algae extract is thorn Asparagus toxiformis (Delile) Coll et Harv red algae
In extract, kappaphycus algae extract, Chondrus crispus extract, coral algae extract any one.
Further, a kind of above-mentioned composition containing red algae extract, the red algae extract is thorn Asparagus toxiformis (Delile) Coll et Harv red algae
The mixing of any two kinds of extracts in extract, kappaphycus algae extract, Chondrus crispus extract, coral algae extract is carried
Thing is taken, the mass ratio of its two kinds of extracts is 1:1.
Further, a kind of above-mentioned composition containing red algae extract, the red algae extract is thorn Asparagus toxiformis (Delile) Coll et Harv red algae
The mixing of any three kinds of extracts in extract, kappaphycus algae extract, Chondrus crispus extract, coral algae extract is carried
Thing is taken, the mass ratio of its three kinds of extracts is 1:1:1.
Further, a kind of above-mentioned composition containing red algae extract, the red algae extract is thorn Asparagus toxiformis (Delile) Coll et Harv red algae
Extract, kappaphycus algae extract, Chondrus crispus extract, the mixed extract of coral algae extract, its four kinds extractions
The mass ratio of thing is 1:1:1:1.
Further, a kind of above-mentioned composition containing red algae extract, the red algae extract passes through following step
It is obtained successively：
1) algae raw material is first used clean water, is dried, crushed, mixed, the acetic acid for adding 3-5 times of raw material weight to measure is water-soluble
Liquid soaks at room temperature 8-12h, is filtered to remove residue, obtains filtrate；
2) toward step 1) in filtrate in add the 5-10 times of distilled water measured, stir and evenly mix, be transferred to ultra high pressure extraction tank
In, under normal temperature condition, 100-300MPa being pressurized to, after pressurize 5-10min, extract is taken out in the release in 2-3s；
3) to by step 2) activated carbon decolorizing is added in the extract that obtains, after filtration, by filtrate with rotating speed 5000-
10000r/min is centrifuged 10-20min, takes supernatant, carries out at nanofiltration desalination under conditions of 20-40bar, temperature 10-30 DEG C
Reason, then filter vacuum is concentrated into 1g/20ml, obtain red algae extract.
Last technical scheme that the present invention is provided is to add the composition containing red algae extract as skin care item
The application of agent.
Compared with prior art, the technical scheme that the present invention is provided has following technological merit：
1st, the active component of the red algae extract prepared in the technical scheme provided in the present invention can strengthen human skin
The function of the NWF NMFs in cuticula, depth moisturizing, control moisture content volatilization improves cuticular water content；Can
A tunic being formed in skin surface, protection and strengthening epidermis function, the cutin for protecting skin is formed so that cell and into fiber finer
Impact of the born of the same parents from the external world such as aging, environmental pollution, ultraviolet injurious factor；And rich in various nutriments, can repair
The keratinocyte of damage and fibroblast regenerate, and increase the synthesis of collagen in skin, increase dermal layer of the skin
Elastomer, with anti crease and anti senile prepared old effect；The active component also has stronger anti-oxidation function (more than VC and VE), energy
Enough stimulating cellular growths, solution fat and anti-inflammatory, do not have any excitant or toxicity to skin, prevent the metabolism that naturally-aged causes
The skin injury that obstacle and UV cause.
2nd, the pale flag root extract isoflavones containing iris in the technical scheme provided in the present invention, with protease suppression
Make and use, the protein (collagen and pancreatopeptidase E) of extracellular matrix can be protected, the synthesis of fixed member can be stimulated, keep
Coagulability inside the endoplasm and skin of dermal-epidermal binder course, protects skin corium and strengthens the barrier effect of skin, reduces water
Shunting is lost, and prevents scaly dry skin, has functions that moisturizing and anti-aging.
3rd, the blackberry, blueberry leaf extract in the technical scheme provided in the present invention, can efficiently suppress matrix metalloproteinase MMP-
9 and MMP-1 activity, reduces collagen, the decomposition of elastin laminin and denaturation that MMP-9 and MMP-1 causes, reduces ultraviolet
The activity of MMP-1 after irradiation, suppresses the activity of elastoser, reduces wrinkle of skin and is formed；Additionally, also having oxidation resistant work(
Effect.
4th, the cotton extract in the technical scheme provided in the present invention is that plant lives obtained by extraction from cotton nectar
Property composition, by seven kinds special and rare small molecule compound sugar constitutes, clinical trial certificate can improve skin barrier work(
Can, reduce the stimulation of skin.
5th, the English walnut seed extract in the technical scheme provided in the present invention extracts from " Grenoble walnuts ", containing phytic acid
And polyphenol.Protected by making skin from oxidative pressure and its side effect for causing (cell ageing and inflammation caused by UV light)
Shield cellular anti-oxidant source, prevents photochemical aging.Meanwhile, it can activate horn cell synthesis propagation with fibroblast albumen again
Synthesis, so as to play a part of to prevent naturally-aged.
6th, the Withania kansuensis root extract in the technical scheme provided in the present invention is rich in glucoside, can promote under extreme condition
Dermal cell growth simultaneously strengthens the defense function of skin.It has recovers skin function, promotes cytothesis and rebuilds barrier work(
The effect of energy, can help improve the stress ability that skin adapts to environment.
Sum it up, the technical scheme that provides of the present invention is by by red algae extract and pale flag root extract, blackberry, blueberry
Leaf extract, cotton extract, English walnut seed extract, Withania kansuensis root extract carry out reasonable compatibility, and Synergistic is mended with moisturizing
Water, prevent scaly dry skin；Layer protecting film is formed in skin surface, improves skin barrier function, protect the skin from aging, ring
The impact of the external world such as border pollution, ultraviolet injurious factor；It is anti-oxidant, skin is made from oxidative pressure and its side effect for causing,
Prevent photochemical aging；Suppress matrix metalloproteinase simultaneously, promote the synthesis of collagen, formed with wrinkle of skin is reduced,
The effect of delay skin aging.
Specific embodiment
With reference to specific embodiment, the claim of the present invention is described in further detail, but do not constitute it is right
Any restriction of the present invention, the modification of anyone limited number of time made in the claims in the present invention protection domain etc still exists
Within the claims of the present invention.
It should be noted that the raw material employed in the technical scheme of present invention offer, outside non-specified otherwise, by normal
Rule means are prepared or bought by commercial channel.
Wherein pale flag root extract, Withania kansuensis root extract are bought in Guangzhou Bi Sheng trade Co., Ltds, blackberry leaf
Extract is purchased in the Hao Bo Co., Ltds of Guangzhou hundred, and cotton extract is purchased in Guangzhou Rong Dao Chemical Co., Ltd.s, English walnut
Seed extract is purchased in Ao Cui trade Co., Ltds.
Embodiment 1
A kind of composition containing red algae extract disclosed by the invention, is made up of the component of following weight number：Thorn Asparagus toxiformis (Delile) Coll et Harv
Red algae extract 30g, pale flag root extract 1g, blackberry, blueberry leaf extract 15g.
Embodiment 2
A kind of composition containing red algae extract disclosed by the invention, is made up of the component of following weight number：Thorn Asparagus toxiformis (Delile) Coll et Harv
Red algae extract 20g, pale flag root extract 10g, blackberry, blueberry leaf extract 5g, cotton extract 10g, English walnut seed extract
1g, Withania kansuensis root extract 5g.
Embodiment 3
A kind of composition containing red algae extract disclosed by the invention, is made up of the component of following weight number：Kappaphycus
Algae extract 5g, pale flag root extract 7g, blackberry, blueberry leaf extract 10g.
Embodiment 4
A kind of composition containing red algae extract disclosed by the invention, is made up of the component of following weight number：Kappaphycus
Algae extract 15g, pale flag root extract 3g, blackberry, blueberry leaf extract 7g, cotton extract 9g, English walnut seed extract 4g is slept
Radix Solani Melongenae extract 3g.
Embodiment 5
A kind of composition containing red algae extract disclosed by the invention, is made up of the component of following weight number：Pitch at ripple angle
Dish extract 20g, pale flag root extract 5g, blackberry, blueberry leaf extract 8g.
Embodiment 6
A kind of composition containing red algae extract disclosed by the invention, is made up of the component of following weight number：Pitch at ripple angle
Dish extract 25g, pale flag root extract 7g, blackberry, blueberry leaf extract 6g, cotton extract 3g, English walnut seed extract 6g is slept
Radix Solani Melongenae extract 1g.
Embodiment 7
A kind of composition containing red algae extract disclosed by the invention, is made up of the component of following weight number：Coralline algae is carried
Take thing 12g, pale flag root extract 8g, blackberry, blueberry leaf extract 9g.
Embodiment 8
A kind of composition containing red algae extract disclosed by the invention, is made up of the component of following weight number：Coralline algae is carried
Take thing 25g, pale flag root extract 5g, blackberry, blueberry leaf extract 12g, cotton extract 4g, English walnut seed extract 3g, Withania kansuensis root
Extract 2g.
Embodiment 9
A kind of composition containing red algae extract disclosed by the invention, is made up of the component of following weight number：Thorn Asparagus toxiformis (Delile) Coll et Harv
Red algae extract 15g, Chondrus crispus extract 15g, pale flag root extract 6g, blackberry, blueberry leaf extract 11g.
Embodiment 10
A kind of composition containing red algae extract disclosed by the invention, is made up of the component of following weight number：Thorn Asparagus toxiformis (Delile) Coll et Harv
Red algae extract 12g, Chondrus crispus extract 12g, pale flag root extract 4g, blackberry, blueberry leaf extract 15g, cotton is extracted
Thing 10g, English walnut seed extract 1g, Withania kansuensis root extract 5g.
Embodiment 11
A kind of composition containing red algae extract disclosed by the invention, is made up of the component of following weight number：Thorn Asparagus toxiformis (Delile) Coll et Harv
Red algae extract 5g, kappaphycus algae extract 5g, pale flag root extract 1g, blackberry, blueberry leaf extract 10g.
Embodiment 12
A kind of composition containing red algae extract disclosed by the invention, is made up of the component of following weight number：Thorn Asparagus toxiformis (Delile) Coll et Harv
Red algae extract 3g, kappaphycus algae extract 3g, pale flag root extract 3g, blackberry, blueberry leaf extract 8g, cotton extract
3g, English walnut seed extract 6g, Withania kansuensis root extract 1g.
Embodiment 13
A kind of composition containing red algae extract disclosed by the invention, is made up of the component of following weight number：Thorn Asparagus toxiformis (Delile) Coll et Harv
Red algae extract 10g, coral algae extract 10g, pale flag root extract 10g, blackberry, blueberry leaf extract 5g.
Embodiment 14
A kind of composition containing red algae extract disclosed by the invention, is made up of the component of following weight number：Thorn Asparagus toxiformis (Delile) Coll et Harv
Red algae extract 9g, coral algae extract 9g, pale flag root extract 5g, blackberry, blueberry leaf extract 8g, cotton extract 6g, recklessly
Peach seed extract 4g, Withania kansuensis root extract 3g.
Embodiment 15
A kind of composition containing red algae extract disclosed by the invention, is made up of the component of following weight number：Kappaphycus
Algae extract 7g, Chondrus crispus extract 7g, pale flag root extract 3g, blackberry, blueberry leaf extract 6g.
Embodiment 16
A kind of composition containing red algae extract disclosed by the invention, is made up of the component of following weight number：Kappaphycus
Algae extract 6g, Chondrus crispus extract 6g, pale flag root extract 2g, blackberry, blueberry leaf extract 8g, cotton extract 8g,
English walnut seed extract 2g, Withania kansuensis root extract 2g.
Embodiment 17
A kind of composition containing red algae extract disclosed by the invention, is made up of the component of following weight number：Pitch at ripple angle
Dish extract 13g, coral algae extract 13g, pale flag root extract 7g, blackberry, blueberry leaf extract 9g.
Embodiment 18
A kind of composition containing red algae extract disclosed by the invention, is made up of the component of following weight number：Pitch at ripple angle
Dish extract 11g, coral algae extract 11g, pale flag root extract 8g, blackberry, blueberry leaf extract 7g, cotton extract 4g, recklessly
Peach seed extract 3g, Withania kansuensis root extract 4g.
Embodiment 19
A kind of composition containing red algae extract disclosed by the invention, is made up of the component of following weight number：Kappaphycus
Algae extract 8g, coral algae extract 8g, pale flag root extract 2g, blackberry, blueberry leaf extract 13g.
Embodiment 20
A kind of composition containing red algae extract disclosed by the invention, is made up of the component of following weight number：Kappaphycus
Algae extract 7g, coral algae extract 7g, pale flag root extract 3g, blackberry, blueberry leaf extract 12g, cotton extract 6g, recklessly
Peach seed extract 2g, Withania kansuensis root extract 2g.
Embodiment 21
A kind of composition containing red algae extract disclosed by the invention, is made up of the component of following weight number：Thorn Asparagus toxiformis (Delile) Coll et Harv
Red algae extract 10g, kappaphycus algae extract 10g, Chondrus crispus extract 10g, pale flag root extract 5g, blackberry, blueberry
Leaf extract 10g.
Embodiment 22
A kind of composition containing red algae extract disclosed by the invention, is made up of the component of following weight number：Thorn Asparagus toxiformis (Delile) Coll et Harv
Red algae extract 9g, kappaphycus algae extract 9g, Chondrus crispus extract 9g, pale flag root extract 4g, blackberry leaf
Extract 8g, cotton extract 10g, English walnut seed extract 6g, Withania kansuensis root extract 3g.
Embodiment 23
A kind of composition containing red algae extract disclosed by the invention, is made up of the component of following weight number：Kappaphycus
Algae extract 5g, Chondrus crispus extract 5g, coral algae extract 5g, pale flag root extract 2g, blackberry, blueberry leaf extract
15g。
Embodiment 24
A kind of composition containing red algae extract disclosed by the invention, is made up of the component of following weight number：Kappaphycus
Algae extract 7g, Chondrus crispus extract 7g, coral algae extract 7g, pale flag root extract 1g, blackberry, blueberry leaf extract
12g, cotton extract 5g, English walnut seed extract 4g, Withania kansuensis root extract 5g.
Embodiment 25
A kind of composition containing red algae extract disclosed by the invention, is made up of the component of following weight number：Thorn Asparagus toxiformis (Delile) Coll et Harv
Red algae extract 2g, Chondrus crispus extract 2g, coral algae extract 2g, pale flag root extract 10g, blackberry leaf is extracted
Thing 5g.
Embodiment 26
A kind of composition containing red algae extract disclosed by the invention, is made up of the component of following weight number：Thorn Asparagus toxiformis (Delile) Coll et Harv
Red algae extract 4g, Chondrus crispus extract 4g, coral algae extract 4g, pale flag root extract 8g, blackberry leaf is extracted
Thing 7g, cotton extract 3g, English walnut seed extract 1g, Withania kansuensis root extract 1g.
Embodiment 27
A kind of composition containing red algae extract disclosed by the invention, is made up of the component of following weight number：Thorn Asparagus toxiformis (Delile) Coll et Harv
Red algae extract 6g, kappaphycus algae extract 6g, coral algae extract 6g, pale flag root extract 6g, blackberry leaf is extracted
Thing 13g.
Embodiment 28
A kind of composition containing red algae extract disclosed by the invention, is made up of the component of following weight number：Thorn Asparagus toxiformis (Delile) Coll et Harv
Red algae extract 8g, kappaphycus algae extract 8g, coral algae extract 8g, pale flag root extract 3g, blackberry leaf is extracted
Thing 11g, cotton extract 8g, English walnut seed extract 3g, Withania kansuensis root extract 2g.
Embodiment 29
A kind of composition containing red algae extract disclosed by the invention, is made up of the component of following weight number：Thorn Asparagus toxiformis (Delile) Coll et Harv
Red algae extract 6g, kappaphycus algae extract 6g, Chondrus crispus extract 6g, coral algae extract 6g, pale flag root
Extract 10g, blackberry, blueberry leaf extract 5g.
Embodiment 30
A kind of composition containing red algae extract disclosed by the invention, is made up of the component of following weight number：Thorn Asparagus toxiformis (Delile) Coll et Harv
Red algae extract 4g, kappaphycus algae extract 4g, Chondrus crispus extract 4g, coral algae extract 4g, pale flag root
Extract 1g, blackberry, blueberry leaf extract 15g, cotton extract 7g, English walnut seed extract 3g, Withania kansuensis root extract 3g.
The preparation method of above-mentioned any one group of red algae extract is as follows：
1) algae raw material (mixing of thorn Asparagus toxiformis (Delile) Coll et Harv red algae or kappaphycus alvarezi or Chondrus crispus or coralline algae) is first used
Clean water, dries, and crushes, and mixes, and adds the 3-5 times of aqueous acetic acid for measuring (preferably 4 times amounts) to soak 8-12h at room temperature
(preferred 10h), is filtered to remove residue, obtains filtrate；
2) toward step 1) in filtrate in add the 5-10 times of distilled water for measuring (preferably 7 times amount), stir and evenly mix, be transferred to super
In high-pressure extracting tank, under normal temperature condition, 100-300MPa (preferred 200MPa) is pressurized to, it is (preferential after pressurize 5-10min
6min), the release in 2-3s, takes out extract；
3) to by step 2) activated carbon decolorizing is added in the extract that obtains, after filtration, by filtrate with rotating speed 5000-
10000r/min (preferred 8000r/min) centrifugations 10-20min (preferred 15min), takes supernatant, in 20-40bar (preferably
30bar), nanofiltration desalination process is carried out under conditions of temperature 10-30 DEG C (preferably 25 DEG C), then filter vacuum is concentrated into 1g/
20ml, obtains red algae extract.
The preparation method of the present composition is that all raw material components are added to successively in a small amount of deionized water, is directly stirred
Mix to be well mixed and obtain final product.
When specifically used, composition prepared by the present invention is added directly in skin care item matrix, is stirred, addition
For the 0.5-8wt% of skin care item gross mass.
In order to better illustrate advantages of the present invention, the composition containing red algae extract of present invention offer is given below
Efficacy test：
First, oxidation resistance evaluation
The mechanism of action of antioxidant mainly includes removing free radical and directly removing two approach of free radical indirectly.Cause
This, the present invention evaluates its antioxidant effect by determining composition to the Scavenging activity of DPPH free radicals and hydroxy radical.
1st, the comparative example of experiment
Comparative example 1
Without thorn Asparagus toxiformis (Delile) Coll et Harv red algae extract, other are same as Example 1.
Comparative example 2
Only contain cotton extract 10g, English walnut seed extract 1g, Withania kansuensis root extract 5g.
2nd, the preparation of sample
Composition prepared by embodiment 1,2,9,10,21,22,29,30 and comparative example 1-2 is made into mass fraction for 1%
Sample solution, carry out experiment below.
3rd, scavenging ability of DPPH free radical test (DPPH methods were suggested in 1958, for quantitative determine Biosample and
The oxidation resistance of food)
The picryl hydrazine of 1,1- diphenyl -2 (1,1-Dipheny1-2-picrylhydrazyl, DPPH, TCI are for selling) is dissolved in
In ethanol, to be formulated as concentration 1.52 × 10-4The DPPH ethanol solutions of M.Then, respectively take the μ L of sample solution 500, and respectively with
After the DPPH ethanol solutions concussion of 2500 μ L is well mixed, at room temperature lucifuge stands 30 minutes, used as experimental group.In addition,
Control group is to replace the solution in previous experiments group with the ethanol solution of 500 μ L.Then measure the experimental group to exist with the control group
Light absorption value during wavelength 517nm, numerical value is higher to represent that the ability for removing DPPH free radicals is stronger.
DPPH free radical scavenging activities (%)=[1- (experimental group light absorption value/control group light absorption value)] × 100
4th, to the Scavenging activity evaluation of hydroxy radical
2mmol/L FeSO are sequentially added in 25mL colorimetric cylinders43mL, 1mmol/L H2O23mL, shakes up, and is subsequently added into
6mmol/L salicylic acid 3mL, shake up, and take out after 37 DEG C of heating water bath 15min, survey its absorbance；It is separately added into certain density
Analyte sample fluid, shakes up, and continues heating water bath 15min, takes out and surveys its absorbance.Following formula is prepare liquid to hydroxy radical (OH)
Clearance rate：
A1 is anti-before sample not add in Scavenging action to hydroxyl free radical (%)=[A1-A2- (A1-A3)]/A1 × 100% formula
Answer the absorbance of system；A2 is the absorbance that sample removes system after OH；A3 is that blank removes system after OH
Absorbance.
5th, experimental result (1<9<21<29<2<10<22<30)
Table 3
Experiment shows, the composition of the present invention can potent removing free radical, with antioxidation.The composition of comparative example 1
Free radical scavenging activity significantly lower than example composition clearance rate, illustrate in the antioxidation that composition is showed,
Red algae extract plays an important role；And the free radical scavenging activity of embodiment 1,9,21,29 increases successively, embodiment 2,
10th, 22,30 free radical scavenging activity increases successively, and illustrating will than a kind of independent oxidation resistance of red algae containing the combination of various red algaes
It is good.
Additionally, clearance rate of the free radical scavenging activity of the composition of comparative example 2 significantly lower than the composition of embodiment 1 and 2, explanation
Red algae extract, pale flag root extract, blackberry, blueberry leaf extract three collocation on the basis of, then with cotton extract, Hu
Peach seed extract, Withania kansuensis root extract carry out reasonable compatibility, can effectively improve the ability of composition removing free radical, synergistic antioxidant
Change effect.
2nd, moisturizing and evaluate the effects such as anti-aging
1st, the comparative example of experiment
Comparative example 3
Without Chondrus crispus extract, other are same as Example 5.
Comparative example 4
Only contain cotton extract 3g, English walnut seed extract 6g, Withania kansuensis root extract 1g.
2nd, laboratory sample
Respectively by the embodiment of the present invention 5,6,15,16,23,24,29,30 and right
The composition of ratio 3 and 4 is added in conventional creams matrix, and addition is 5%, and sample A1-A8 is designated as successively
And B1 and B2.
3rd, experimental technique
Choose dry skin, have the healthy volunteer 55 of the wrinkle puzzlements such as dry line, microgroove, expression line, age 30-45
Year, average 40.7 years old, without serious systemic disease, immune deficiency or autoimmune disease, to cosmetics without allergy, face without urgency
Property inflammation, be not used hormone medicine or immunodepressant, do not participate in other clinical testings, do not smear external preparation.Random point
For 11 groups, 5 per group, respectively using test specimen A1-A8, B1-B2 and face cream matrix.
After each group volunteer is with warm water cleaning skin, in face, near the eyes, the back of the hand (same position) uniform application tries accordingly
Sample or face cream matrix are tested, it is sooner or later each 1 time daily, it is continuous using after 8 weeks, carry out following measurement.
The water content (%) in skin of dorsum of hand cuticula is measured using moisture of skin measuring instrument Corneometer CM825,
Using lost analyzer TM300 measurements skin of dorsum of hand water loss amount [TEWL, g/ (hm2)] of transepidermal water, TEWL values can be anti-
Reflecting improves the effect of skin barrier function, and TEWL values are lower, and moisture loss is fewer, shows that skin barrier function is better.
Facial skin elasticity (negative pressure is constant for 450mpa in test process) is tested using skin elasticity tester MPA580,
As a result represented with the ratio of maximum tension amount Uf of skin with springback capacity Ur (cancelling the recovery value of skin after negative pressure 0.1 second),
Numerical value illustrates that skin elasticity is better closer to 1.
Periocualr skin wrinkle is tested using wrinkle of skin tester SV600 (skin of institute's measurement site is first replicated with silicon mould
Wrinkle model, computer carries out grade separation and statistical disposition according to wrinkle of skin depth), calculate sample and use after front, use
Skin mean roughness R3 (i.e.：Arithmetic mean number, wherein R1 tables are taken to the R1 values measured by 5 equal lengths, different segment
Show the distance between peak value and minimum in certain length, μm).As a result with Δ R3 (i.e.：Using before sample with using sample after
Skin mean roughness difference) represent, numerical value is higher, represents effect improving wrinkles better.Concrete test data is shown in Table 2.
Table 2
Above-mentioned experimental data shows that the composition of the present invention can effectively improve skin water content, reduces moisture of skin and scatters and disappears,
Strengthen skin barrier function, increase elasticity of skin, improve the roughness and wrinkle of skin, the effect with moisturizing and anti-aging.
It is significantly lower than using the change of the moisture content of skin after sample B1, elastic parameter and skin mean roughness and uses sample
The corresponding numerical value of A1-A8, water loss amount TEWL values illustrate red algae extract apparently higher than the TEWL values using sample A1-A8
Play an important role in moisturizing, enhancing skin barrier function and senile-resistant efficacy in composition；And sample A1, A3, A5,
Each test value of A7 increases successively, and each test value of sample A2, A4, A6, A8 increases successively, illustrates the combination containing various red algaes than single
Solely a kind of moisturizing of red algae, enhancing skin barrier function and anti-aging effects will get well.
Additionally, after using sample B2, the change of moisture content of skin, elastic parameter and skin mean roughness is significantly lower than and uses
Corresponding test value after sample A1 and A2, TEWL value of the water loss amount TEWL values apparently higher than after using sample A1 and A2, says
It is bright red algae extract, pale flag root extract, blackberry, blueberry leaf extract three collocation on the basis of, then with cotton extract,
English walnut seed extract, Withania kansuensis root extract carry out reasonable compatibility, can effectively improve the moisturizing of composition and the ability of anti-aging, and
Strengthen skin barrier function.
Sum it up, the technical scheme that the present invention is provided is prepared for red algae extract, and by by red algae extract with it is fragrant
Root iris root extract, blackberry, blueberry leaf extract, cotton extract, English walnut seed extract, Withania kansuensis root extract carry out reasonable compatibility,
Synergistic, with moisturizing moisturizing, prevents scaly dry skin；Layer protecting film is formed in skin surface, improves skin barrier function,
Protect the skin from the impact of the external world such as aging, environmental pollution, ultraviolet injurious factor；It is anti-oxidant, skin is made from oxidation pressure
Power and its side effect for causing, prevent photochemical aging；Suppress matrix metalloproteinase simultaneously, promote the synthesis of collagen, tool
It is reduced wrinkle of skin to be formed, the effect of delay skin aging.
Claims (8)
1. a kind of composition containing red algae extract, it is characterised in that be mainly made up of the component of following weight portion：Red algae is extracted
Thing 5-30 parts, pale flag root extract 1-10 parts, blackberry, blueberry leaf extract 5-15 parts.
2. a kind of composition containing red algae extract according to claim 1, it is characterised in that also including cotton extract
3-10 parts, English walnut seed extract 1-6 part, Withania kansuensis root extract 1-5 parts.
3. a kind of composition containing red algae extract according to claim 1, it is characterised in that the red algae extract is
It is any one in thorn Asparagus toxiformis (Delile) Coll et Harv red algae extract, kappaphycus algae extract, Chondrus crispus extract, coral algae extract thing
Kind.
4. a kind of composition containing red algae extract according to claim 1, it is characterised in that the red algae extract is
Any two kinds carry in thorn Asparagus toxiformis (Delile) Coll et Harv red algae extract, kappaphycus algae extract, Chondrus crispus extract, coral algae extract
The mixed extract of thing is taken, the mass ratio of its two kinds of extracts is 1:1.
5. a kind of composition containing red algae extract according to claim 1, it is characterised in that the red algae extract is
Any three kinds carry in thorn Asparagus toxiformis (Delile) Coll et Harv red algae extract, kappaphycus algae extract, Chondrus crispus extract, coral algae extract
The mixed extract of thing is taken, the mass ratio of its three kinds of extracts is 1:1:1.
6. a kind of composition containing red algae extract according to claim 1, it is characterised in that the red algae extract is
Mixing in thorn Asparagus toxiformis (Delile) Coll et Harv red algae extract, kappaphycus algae extract, Chondrus crispus extract, coral algae extract is extracted
Thing, the mass ratio of its four kinds of extracts is 1:1:1:1.
7. a kind of composition containing red algae extract according to claim 1, it is characterised in that the red algae extract leads to
Cross following step to be obtained successively：
1) algae raw material is first used clean water, is dried, crushed, mixed, add the aqueous acetic acid that 3-5 times of raw material weight is measured to exist
8-12h is soaked under room temperature, residue is filtered to remove, filtrate is obtained；
2) toward step 1) in filtrate in add the 5-10 times of distilled water measured, stir and evenly mix, in being transferred to ultra high pressure extraction tank,
Under normal temperature condition, 100-300MPa is pressurized to, after pressurize 5-10min, extract is taken out in the release in 2-3s；
3) to by step 2) activated carbon decolorizing is added in the extract that obtains, after filtration, by filtrate with rotating speed 5000-10000r/
Min is centrifuged 10-20min, takes supernatant, and nanofiltration desalination process is carried out under conditions of 20-40bar, temperature 10-30 DEG C, then will
Filter vacuum is concentrated to 1g/20ml, obtains red algae extract.
8. application of a kind of composition containing red algae extract described in claim 1 as skin-care product additive.
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108078829A (en) * | 2018-01-12 | 2018-05-29 | 广州赛莱拉干细胞科技股份有限公司 | The shin moisturizer of wool multitube algae extract |
| CN108078869A (en) * | 2018-02-02 | 2018-05-29 | 广州市聚吉科绿色化学共性技术研究院有限公司 | A kind of adsorbing composition |
| CN111789800A (en) * | 2020-08-14 | 2020-10-20 | 郑州凯莉莱生物科技有限公司 | Aloe composite repair factor and preparation method thereof |
| CN112245332A (en) * | 2020-12-02 | 2021-01-22 | 青岛博智汇力生物科技有限公司 | Eczema gel containing marine oligosaccharide |
| CN112704713A (en) * | 2021-01-07 | 2021-04-27 | 中国海洋大学 | Kappaphycus cereal powder formula for improving intestinal mucositis caused by chemotherapy |
| CN112716855A (en) * | 2021-01-27 | 2021-04-30 | 科丝美诗(中国)化妆品有限公司 | Composition with barrier repairing and anti-aging effects and preparation method and application thereof |
| CN112891296A (en) * | 2021-02-02 | 2021-06-04 | 杭州百芮生物科技有限公司 | Hair and scalp care micro-ecological composition and preparation method thereof |
Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2815539A1 (en) * | 2000-10-23 | 2002-04-26 | Silab Sa | Active principle rich in isoflavones for use in anti-aging cosmetic compositions, extracted from the rhizome of Iris Florentina |
| US20040166184A1 (en) * | 2002-12-03 | 2004-08-26 | Natreon Inc. | Withania somnifera composition, method for obtaining same and pharmaceutical, nutritional and personal care formulations thereof |
| US20060018868A1 (en) * | 2002-12-03 | 2006-01-26 | Claude Dal Farra | Use of a cotton honeydew extract as active ingredient in or for preparing a cosmetic and/or pharmaceutical composition |
| CN1785158A (en) * | 2004-12-09 | 2006-06-14 | 湛江海洋大学 | Skin care cream made of natural seaweed and its prepn. method |
| FR2902656A1 (en) * | 2006-06-23 | 2007-12-28 | Limousine D Applic Biolog Dite | Active agent for cosmetic skin treatment, having e.g. protecting, repair promoting, moisturizing, antiaging and anti-wrinkle effects, comprises extract of Withania somnifera |
| CN101528194A (en) * | 2006-09-26 | 2009-09-09 | 巴斯夫美容护理公司 | Marine extracts and biofermentations for use in cosmetics |
| CN101810552A (en) * | 2009-02-20 | 2010-08-25 | 强生消费者公司 | The compositions and the method that are used for the treatment of signs of skin aging |
| CN102283790A (en) * | 2010-06-18 | 2011-12-21 | 孙洁 | Seaweed manual facial mask and preparation method thereof |
| CN102475665A (en) * | 2010-11-30 | 2012-05-30 | 株式会社爱茉莉太平洋 | Anti-aging cosmetic composition containing red algae extract |
| CN102552097A (en) * | 2011-11-24 | 2012-07-11 | 林展新 | Pearl red algae ecotype skin-care product and manufacture method thereof |
| CN105395434A (en) * | 2015-12-21 | 2016-03-16 | 宁波大学 | Application of floridoside to cosmetics |
-
2016
- 2016-12-16 CN CN201611166925.9A patent/CN106619239A/en active Pending
Patent Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2815539A1 (en) * | 2000-10-23 | 2002-04-26 | Silab Sa | Active principle rich in isoflavones for use in anti-aging cosmetic compositions, extracted from the rhizome of Iris Florentina |
| US20040166184A1 (en) * | 2002-12-03 | 2004-08-26 | Natreon Inc. | Withania somnifera composition, method for obtaining same and pharmaceutical, nutritional and personal care formulations thereof |
| US20060018868A1 (en) * | 2002-12-03 | 2006-01-26 | Claude Dal Farra | Use of a cotton honeydew extract as active ingredient in or for preparing a cosmetic and/or pharmaceutical composition |
| CN1785158A (en) * | 2004-12-09 | 2006-06-14 | 湛江海洋大学 | Skin care cream made of natural seaweed and its prepn. method |
| FR2902656A1 (en) * | 2006-06-23 | 2007-12-28 | Limousine D Applic Biolog Dite | Active agent for cosmetic skin treatment, having e.g. protecting, repair promoting, moisturizing, antiaging and anti-wrinkle effects, comprises extract of Withania somnifera |
| CN101528194A (en) * | 2006-09-26 | 2009-09-09 | 巴斯夫美容护理公司 | Marine extracts and biofermentations for use in cosmetics |
| CN101810552A (en) * | 2009-02-20 | 2010-08-25 | 强生消费者公司 | The compositions and the method that are used for the treatment of signs of skin aging |
| CN102283790A (en) * | 2010-06-18 | 2011-12-21 | 孙洁 | Seaweed manual facial mask and preparation method thereof |
| CN102475665A (en) * | 2010-11-30 | 2012-05-30 | 株式会社爱茉莉太平洋 | Anti-aging cosmetic composition containing red algae extract |
| CN102552097A (en) * | 2011-11-24 | 2012-07-11 | 林展新 | Pearl red algae ecotype skin-care product and manufacture method thereof |
| CN105395434A (en) * | 2015-12-21 | 2016-03-16 | 宁波大学 | Application of floridoside to cosmetics |
Non-Patent Citations (3)
| Title |
|---|
| MARTINA HERRMANN等: "Blackberry leaf extract: a multifunctional anti-aging active", 《INTERNATIONAL JOURNAL OF COSMETIC SCIENCE》 * |
| 柏林的最爱: "活性物原料目录", 《360个人图书馆（HTTP://WWW.360DOC.COM/CONTENT/12/0506/22/413416_209145002.SHTML）》 * |
| 章苏宁: "《化妆品工艺学》", 30 September 2007, 中国轻工业出版社 * |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108078829A (en) * | 2018-01-12 | 2018-05-29 | 广州赛莱拉干细胞科技股份有限公司 | The shin moisturizer of wool multitube algae extract |
| CN108078869A (en) * | 2018-02-02 | 2018-05-29 | 广州市聚吉科绿色化学共性技术研究院有限公司 | A kind of adsorbing composition |
| CN111789800A (en) * | 2020-08-14 | 2020-10-20 | 郑州凯莉莱生物科技有限公司 | Aloe composite repair factor and preparation method thereof |
| CN112245332A (en) * | 2020-12-02 | 2021-01-22 | 青岛博智汇力生物科技有限公司 | Eczema gel containing marine oligosaccharide |
| CN112704713A (en) * | 2021-01-07 | 2021-04-27 | 中国海洋大学 | Kappaphycus cereal powder formula for improving intestinal mucositis caused by chemotherapy |
| CN112716855A (en) * | 2021-01-27 | 2021-04-30 | 科丝美诗(中国)化妆品有限公司 | Composition with barrier repairing and anti-aging effects and preparation method and application thereof |
| CN112891296A (en) * | 2021-02-02 | 2021-06-04 | 杭州百芮生物科技有限公司 | Hair and scalp care micro-ecological composition and preparation method thereof |
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Application publication date: 20170510 |