CN110772443B - Hyaluronic acid moisturizing and repairing composition and preparation method thereof - Google Patents
Hyaluronic acid moisturizing and repairing composition and preparation method thereof Download PDFInfo
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- CN110772443B CN110772443B CN201911300239.XA CN201911300239A CN110772443B CN 110772443 B CN110772443 B CN 110772443B CN 201911300239 A CN201911300239 A CN 201911300239A CN 110772443 B CN110772443 B CN 110772443B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/67—Piperaceae (Pepper family), e.g. Jamaican pepper or kava
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/77—Sapindaceae (Soapberry family), e.g. lychee or soapberry
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/524—Preservatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The invention belongs to the field of cosmetics, and particularly relates to a hyaluronic acid moisturizing and repairing composition and a preparation method thereof. The hyaluronic acid moisturizing and repairing composition provided by the invention comprises the following components in percentage by weight: 0.84 to 6.08 percent of humectant A, 2.24 to 9.63 percent of humectant B, 0.1 to 0.6 percent of preservative, 0.1 to 0.8 percent of anti-allergic agent, 0.03 to 0.13 percent of thickening agent, 0.03 to 0.13 percent of pH regulator, 0.13 to 1.18 percent of 1,2 hexanediol and 81.45 to 96.53 percent of water. The hyaluronic acid moisturizing and repairing composition humectant, the preservative, the antiallergic agent, the thickening agent and the pH regulator provided by the invention are coordinated with each other, so that the hyaluronic acid moisturizing and repairing composition has good moisturizing, anti-wrinkle, repairing and antioxidant properties.
Description
Technical Field
The invention belongs to the field of cosmetics, and particularly relates to a hyaluronic acid moisturizing and repairing composition and a preparation method thereof.
Background
Along with the improvement of the living quality of people and the pursuit of people for beauty, cosmetic varieties are more and more, and the original deep nourishing care product of the facial mask becomes a daily product for skin care of people. The principle of the facial mask is that the facial mask is covered on the face for a short time, so that the external air and pollution are temporarily isolated, the skin temperature is increased, pores of the skin are expanded, the secretion and metabolism of sweat glands are promoted, the oxygen content of the skin is increased, the skin is favorable for removing products of epidermal cell metabolism and accumulated grease substances, and water and nutritional or functional substances in the facial mask permeate into the horny layer of the skin epidermis to soften the skin and make the skin naturally bright and elastic.
At present, the commercially available facial masks are various in types and countless in types. The facial mask can be mainly divided into a cleaning facial mask, a moisturizing facial mask, a soothing facial mask, a firming facial mask, a regenerating facial mask, a whitening facial mask, a moisturizing facial mask and an anti-wrinkle facial mask according to different effects, and the facial masks of the types can not only remove dirt and redundant grease in pores, remove aged cutin, enable skin to be fresh and clean, but also lock skin moisture and prevent skin aging.
The Chinese patent application CN107648057A discloses a long-acting moisturizing and repairing biological fiber mask which has good synergistic moisturizing and repairing effects on skin, but allergic symptoms such as skin flushing and itching are easily caused by adding nicotinamide into the mask.
Chinese patent application CN 108245470A discloses a moisture-keeping anti-wrinkle mask, the mask liquid of the mask consists of an emulsifier, a humectant, a preservative, skin oil, a pH regulator and an anti-wrinkle repair substance, although the mask has good short-time water-replenishing and moisture-keeping effects, the long-acting moisture-keeping effect of the mask is general, the moisture of the skin can be kept only within 2-3h, and the moisture can not be locked for a long time.
The problems that water replenishing and moisture retaining and skin repairing cannot be achieved simultaneously, allergy is easy to occur and long-acting moisture retaining cannot be achieved after the mask is used in the using process of the existing mask need to be solved urgently.
Disclosure of Invention
In order to solve the defects of the prior art, the invention provides a hyaluronic acid moisturizing and anti-wrinkle composition and a preparation method thereof. The hyaluronic acid moisturizing and anti-wrinkle composition provided by the invention adopts the mixture ratio of allantoin, glycerin, 1,2 hexanediol, propylene glycol, macromolecular sodium hyaluronate, low molecular sodium hyaluronate and erythritol as the moisturizing agent to perform long-acting moisturizing, meanwhile, the preservative adopts the mixture ratio of jasminolone and litchi leaf extract, and the antiallergic agent adopts the combination of kava kava and melissa extract, so that the facial mask liquid has good long-acting moisturizing, anticorrosion and antiallergic effects, and meanwhile, the facial mask liquid also has good effects of removing freckles, resisting wrinkles and repairing skins.
The technical scheme of the invention is as follows:
a hyaluronic acid moisturizing and repairing composition comprises the following components in percentage by weight:
0.84 to 6.08 percent of humectant A, 2.24 to 9.63 percent of humectant B, 0.1 to 0.6 percent of preservative, 0.1 to 0.8 percent of antiallergic agent, 0.03 to 0.13 percent of thickening agent, 0.03 to 0.13 percent of pH regulator, 0.13 to 1.18 percent of 1,2 hexanediol and 81.45 to 96.53 percent of water;
the humectant A comprises the following components in parts by weight:
1-3 parts of allantoin and 30-100 parts of glycerol;
the humectant B comprises the following components in parts by weight:
80-150 parts of propylene glycol, 1-6 parts of macromolecular sodium hyaluronate, 1-4 parts of low molecular sodium hyaluronate and 1-3 parts of erythritol.
Further, the hyaluronic acid moisturizing and repairing composition comprises the following components in percentage by weight:
humectant A3.31%, humectant B6.95%, antiseptic 0.4%, antiallergic agent 0.3%, thickener 0.1%, pH regulator 0.1%, 1,2 hexanediol 0.64% and water 88.2%;
the humectant A comprises the following components in parts by weight:
2 parts of allantoin and 60 parts of glycerol;
the humectant B comprises the following components in parts by weight:
120 parts of propylene glycol, 5 parts of macromolecular sodium hyaluronate, 3 parts of low molecular sodium hyaluronate and 2 parts of erythritol.
Furthermore, the preservative consists of the jasminolone and the litchi leaf extract according to the weight ratio of 5-9.
Further, the preservative consists of the jasminodone and the litchi leaf extract according to the weight ratio of 7.
Further, the antiallergic agent consists of kava kava and melissa officinalis extract according to a weight ratio of 2-3.
Further, the antiallergic agent consists of kava kava and melissa extract according to a weight ratio of 7.
Further, the thickening agent is carbomer 941; the pH regulator is triethanolamine.
The invention also provides application of the hyaluronic acid moisturizing and repairing composition in preparation of stock solutions and emulsions of cold application masks.
The invention also provides a preparation method of the hyaluronic acid moisturizing and repairing composition, which comprises the following steps:
s1, adding carbomer 941 and 1,2 hexanediol into water with the total water volume of 99% and soaking for 24 hours in an emulsifying cylinder with the capacity of 100 kg;
s2, adding allantoin, glycerol, jasminolone and litchi leaf extract into an emulsifying tank filled with carbomer 941 and 1,2 hexanediol soaked in the step S1, heating to 80 ℃ under the stirring condition of 25r/min, preserving heat for 20min when the temperature of the emulsifying tank reaches 80 ℃, then opening a cooling system of the emulsifying tank, keeping the speed unchanged, continuing stirring, and cooling to 45 ℃ to obtain a component A;
s3, sequentially adding erythritol, propylene glycol, macromolecular sodium hyaluronate and low-molecular sodium hyaluronate into the component A prepared in the step S2, and stirring at the speed of 25r/min for 15min to obtain a component B;
s4, adding kava kava and melissa extract into the component B prepared in the step S3;
s5, dissolving a pH regulator triethanolamine in water according to the proportion to obtain a component C;
s6, adding the component C prepared in the step S5 into the component B prepared in the step S4, stirring for 5min at a constant speed to obtain a component D with pH = 4.5-6.5;
s7, continuously stirring the component D prepared in the step S6 uniformly, stopping stirring to obtain a mask liquid, sampling, detecting and reserving a sample;
and S8, passing the qualified facial mask liquid through a 200-mesh filter screen, and then sealing and storing to obtain the facial mask liquid.
The invention adopts the following raw material selective purchasing instructions:
the molecular weight of the macromolecular sodium hyaluronate is from 100 ten thousand Da to 170 ten thousand Da, a breathable film can be formed on the skin epidermis, so that the skin is smooth and moist, the invasion of external bacteria, dust and ultraviolet rays can be blocked, and the skin is protected from being damaged; in short, the film-forming property is better, namely the water retention capacity is better.
The low molecular sodium hyaluronate has molecular weight of 28-80 ten thousand Da, can penetrate into dermis, and has effects of slightly dilating capillary, increasing blood circulation, promoting metabolism, and improving skin nutrition absorption.
The xinxian ketone (p-hydroxyacetophenone) has antioxidant, anti-irritation, stable emulsion and broad-spectrum antiseptic ability. The facial mask has good water solubility, overcomes the defect that a plurality of preservatives or preservative substitute products are not easy to add, has the effects of resisting stimulation and inhibiting inflammatory factors, and is a preservative substitute product because the preservative can be replaced in the facial mask.
kava kava is available from CRODA as dried root extract of kava of the family piperitaceae, kavalactone, kavalanone, etc. Contains kavain, dihydrokavain, methoxykavain and demethoxykavain 6 kavain, and has various pharmacological effects of tranquilizing, hypnotizing, resisting bacteria, relieving pain, etc.
The litchi leaf extract is obtained from Sabina chinensis biological technology Limited, and is prepared by sun-drying, decocting and extracting leaves of litchi of Sapindaceae, and has effects of removing dampness and removing toxic substances.
Melissa extract is obtained from Xian Tian biological technology corporation, and is the extract of pollen of Melissa, belonging to perennial herb of Labiatae, and has effects of tranquilizing mind, promoting digestion, relieving stress and tranquilizing mind.
Compared with the prior art, the invention has the following beneficial effects:
(1) The hyaluronic acid moisturizing repair composition provided by the invention adopts the mixture ratio of allantoin, glycerol, propylene glycol, macromolecular sodium hyaluronate, low molecular sodium hyaluronate and erythritol as the moisturizing agent, and 1, 2-hexanediol is added, so that the composition has the effects of moisturizing, forming a layer of protective film on the surface layer of skin, isolating pollutants, cleaning and long-acting moisturizing, and meanwhile, the components are mutually mixed, so that the composition has a good whitening repair function, and can promote skin cell repair;
(2) The hyaluronic acid moisturizing and repairing composition preservative adopts the jasminonone and the lychee leaf extract in a ratio, meanwhile, the 1, 2-hexanediol has a certain preservative effect, the content of toxic components is reduced by the reduced preservative amount, the preservative effect is not weakened, the adopted lychee leaf extract has the effects of sterilizing, diminishing inflammation and preventing rot, and the rapid recovery of skin injury parts can be promoted while the preservative is preserved;
(3) The hyaluronic acid moisturizing repair composition disclosed by the invention adopts kava kava and bee pollen extracts for matching use, has a good antiallergic effect, is suitable for any skin, and is synergistic with each other, so that the fragrance of the mask stock solution is increased, the effects of soothing nerves and promoting sleep are achieved, and the repair effect of the mask stock solution on skin is promoted;
(4) The hyaluronic acid moisturizing and repairing composition humectant, the preservative, the antiallergic agent, the thickening agent and the pH regulator are mutually coordinated, and have good effects of long-acting moisturizing, freckle removing, wrinkle resisting and skin repairing.
Detailed Description
The present invention will be described in further detail with reference to the following examples. It should not be understood that the scope of the above-described subject matter of the present invention is limited to the following examples.
Example 1 moisturizing repair composition of hyaluronic acid
The hyaluronic acid moisturizing and repairing composition consists of the following components in percentage by weight:
0.84% of humectant A, 2.24% of humectant B, 0.1% of preservative, 0.1% of antiallergic agent, 0.03% of thickening agent, 0.03% of pH regulator, 0.13% of 1,2 hexanediol and 96.53% of water.
The humectant A comprises the following components in parts by weight:
1 part of allantoin and 30 parts of glycerol;
the humectant B comprises the following components in parts by weight:
80 parts of propylene glycol, 1 part of macromolecular sodium hyaluronate, 1 part of low molecular sodium hyaluronate and 1 part of erythritol.
The preservative consists of the jasminolone and the litchi leaf extract according to the weight ratio of 5.
The antiallergic agent consists of kava kava and melissa extract according to a weight ratio of 2.
The thickening agent is carbomer 941; the pH regulator is triethanolamine.
The preparation method of the hyaluronic acid moisturizing and repairing composition comprises the following steps:
s1, adding carbomer 941 and 1,2 hexanediol into water with the total water volume of 99%, and soaking in an emulsion cylinder with the volume of 100kg for 24 hours;
s2, adding allantoin, glycerol, jasminorange ketone and litchi leaf extract into an emulsifying cylinder containing carbomer 941 and 1,2 hexanediol soaked in the step S1, heating to 80 ℃ under the stirring condition of 25r/min, preserving the temperature for 20min when the temperature of the emulsifying cylinder reaches 80 ℃, then opening a cooling system of the emulsifying cylinder, keeping the speed unchanged, continuing stirring, and cooling to 45 ℃ to obtain a component A;
s3, sequentially adding erythritol, propylene glycol, macromolecular sodium hyaluronate and low-molecular transparent sodium hyaluronate into the component A prepared in the step S2, and stirring at the speed of 25r/min for 15min to obtain a component B;
s4, adding kava kava and bee pollen extracts into the component B prepared in the step S3;
s5, dissolving triethanolamine serving as a pH regulator into water according to the proportion to obtain a component C;
s6, adding the component C prepared in the step S5 into the component B prepared in the step S4, stirring for 5min at a constant speed to obtain a component D with pH = 4.5;
s7, continuously stirring the component D prepared in the step S6 uniformly, stopping stirring to obtain a mask liquid, sampling, detecting and reserving a sample;
and S8, passing the qualified facial mask liquid through a 200-mesh filter screen, and then sealing and storing to obtain the facial mask liquid.
Example 2 hyaluronic acid moisturizing repair composition
The hyaluronic acid moisturizing and repairing composition consists of the following components in percentage by weight:
6.08 percent of humectant A, 9.63 percent of humectant B, 0.6 percent of preservative, 0.8 percent of antiallergic agent, 0.13 percent of thickening agent, 0.13 percent of pH regulator, 1.18 percent of 1,2 hexanediol and 81.45 percent of water.
The humectant A comprises the following components in parts by weight:
3 parts of allantoin and 100 parts of glycerol;
the humectant B comprises the following components in parts by weight:
150 parts of propylene glycol, 6 parts of macromolecular sodium hyaluronate, 4 parts of low-molecular sodium hyaluronate and 3 parts of erythritol.
The preservative consists of the jasminolone and the litchi leaf extract according to the weight ratio of 9.
The antiallergic agent consists of kava kava and melissa extract according to a weight ratio of 3.
The thickening agent is carbomer 941; the pH regulator is triethanolamine.
The preparation method of the hyaluronic acid moisturizing and repairing composition comprises the following steps:
s1, adding carbomer 941 and 1,2 hexanediol into water with the total water volume of 99% and soaking for 24 hours in an emulsifying cylinder with the capacity of 100 kg;
s2, adding allantoin, glycerol, jasminoin and lychee leaf extract into an emulsifying cylinder filled with the carbomer 941 and 1,2 hexanediol soaked in the step S1, heating to 80 ℃ under the stirring condition of 25r/min, keeping the temperature for 20min when the temperature of the emulsifying cylinder reaches 80 ℃, then opening a cooling system of the emulsifying cylinder, keeping the speed unchanged, continuing stirring, and cooling to 45 ℃ to obtain a component A;
s3, sequentially adding erythritol, propylene glycol, macromolecular sodium hyaluronate and low-molecular transparent sodium hyaluronate into the component A prepared in the step S2, and stirring at the speed of 25r/min for 15min to obtain a component B;
s4, adding kava kava and melissa extract into the component B prepared in the step S3;
s5, dissolving triethanolamine serving as a pH regulator into water according to the proportion to obtain a component C;
s6, adding the component C prepared in the step S5 into the component B prepared in the step S4, stirring for 5min at a constant speed to obtain a component D with pH = 6.5;
s7, continuously stirring the component D prepared in the step S6 uniformly, stopping stirring to obtain a mask liquid, sampling, detecting and reserving a sample;
and S8, passing the qualified facial mask liquid through a 200-mesh filter screen, and then sealing and storing to obtain the facial mask liquid.
Example 3 hyaluronic acid moisturizing repair composition
The hyaluronic acid moisturizing and repairing composition comprises the following components in percentage by weight:
humectant A3.31%, humectant B6.95%, antiseptic 0.4%, antiallergic agent 0.3%, thickener 0.1%, pH regulator 0.1%, 1,2 hexanediol 0.64% and water 88.2%.
The humectant A comprises the following components in parts by weight:
2 parts of allantoin and 60 parts of glycerol;
the humectant B comprises the following components in parts by weight:
120 parts of propylene glycol, 5 parts of macromolecular sodium hyaluronate, 3 parts of low molecular sodium hyaluronate and 2 parts of erythritol.
The preservative consists of the jasminolone and the litchi leaf extract according to the weight ratio of 7.
The antiallergic agent consists of kava kava and melissa extract according to a weight ratio of 7.
The thickening agent is carbomer 941; the pH regulator is triethanolamine.
The preparation method of the hyaluronic acid moisturizing and repairing composition comprises the following steps:
s1, adding carbomer 941 and 1,2 hexanediol into water with the total water volume of 99% and soaking for 24 hours in an emulsifying cylinder with the capacity of 100 kg;
s2, adding allantoin, glycerol, jasminorange ketone and litchi leaf extract into an emulsifying cylinder containing carbomer 941 and 1,2 hexanediol soaked in the step S1, heating to 80 ℃ under the stirring condition of 25r/min, preserving the temperature for 20min when the temperature of the emulsifying cylinder reaches 80 ℃, then opening a cooling system of the emulsifying cylinder, keeping the speed unchanged, continuing stirring, and cooling to 45 ℃ to obtain a component A;
s3, sequentially adding erythritol, propylene glycol, macromolecular sodium hyaluronate and low-molecular transparent sodium hyaluronate into the component A prepared in the step S2, and stirring at the speed of 25r/min for 15min to obtain a component B;
s4, adding kava kava and bee pollen extracts into the component B prepared in the step S3;
s5, dissolving a pH regulator triethanolamine in water according to the proportion to obtain a component C;
s6, adding the component C prepared in the step S5 into the component B prepared in the step S4, stirring for 5min at a constant speed to obtain a component D with pH = 5;
s7, continuously stirring the component D prepared in the step S6 uniformly, stopping stirring to obtain a mask liquid, sampling, detecting and reserving a sample;
and S8, passing the qualified facial mask liquid through a 200-mesh filter screen, and then sealing and storing to obtain the facial mask liquid.
Example 4 hyaluronic acid moisturizing repair composition
The hyaluronic acid moisturizing and repairing composition comprises the following components in percentage by weight:
humectant A3.45%, humectant B7.53%, antiseptic 0.43%, antiallergic agent 0.5%, thickener 0.09%, pH regulator 0.07%, 1,2 hexanediol 0.59%, and water 87.34%.
The humectant A comprises the following components in parts by weight:
1 part of allantoin and 80 parts of glycerol;
the humectant B comprises the following components in parts by weight:
130 parts of propylene glycol, 4 parts of macromolecular sodium hyaluronate, 2 parts of low molecular sodium hyaluronate and 2 parts of erythritol.
The preservative consists of the jasminodone and the litchi leaf extract according to the weight ratio of 6.
The antiallergic agent consists of kava kava and melissa officinalis extract according to a weight ratio of 8.
The thickening agent is carbomer 941; the pH regulator is triethanolamine.
The preparation method of the hyaluronic acid moisturizing and repairing composition comprises the following steps:
s1, adding carbomer 941 and 1,2 hexanediol into water with the total water volume of 99%, and soaking in an emulsion cylinder with the volume of 100kg for 24 hours;
s2, adding allantoin, glycerol, jasminoin and lychee leaf extract into an emulsifying cylinder filled with the carbomer 941 and 1,2 hexanediol soaked in the step S1, heating to 80 ℃ under the stirring condition of 25r/min, keeping the temperature for 20min when the temperature of the emulsifying cylinder reaches 80 ℃, then opening a cooling system of the emulsifying cylinder, keeping the speed unchanged, continuing stirring, and cooling to 45 ℃ to obtain a component A;
s3, sequentially adding erythritol, propylene glycol, macromolecular sodium hyaluronate and low-molecular transparent sodium hyaluronate into the component A prepared in the step S2, and stirring at the speed of 25r/min for 15min to obtain a component B;
s4, adding kava kava and melissa extract into the component B prepared in the step S3;
s5, dissolving a pH regulator triethanolamine in water according to the proportion to obtain a component C;
s6, adding the component C prepared in the step S5 into the component B prepared in the step S4, stirring for 5min at a constant speed to obtain a component D with pH = 6;
s7, continuously stirring the component D prepared in the step S6 uniformly, stopping stirring to obtain a mask liquid, sampling, detecting and reserving a sample;
and S8, passing the qualified facial mask liquid through a 200-mesh filter screen, and then sealing and storing to obtain the facial mask liquid.
Comparative example 1 hyaluronic acid moisturizing and repairing composition
The hyaluronic acid moisturizing and repairing composition consists of the following components in percentage by weight:
3.31 percent of humectant A, 6.95 percent of humectant B, 0.4 percent of preservative, 0.3 percent of antiallergic agent, 0.1 percent of thickening agent, 0.1 percent of pH regulator, 0.64 percent of 1,2 hexanediol and 88.2 percent of water.
The humectant A is glycerol;
the humectant B comprises the following components in parts by weight:
120 parts of propylene glycol, 5 parts of macromolecular sodium hyaluronate, 3 parts of low molecular sodium hyaluronate and 2 parts of erythritol.
The preservative consists of the jasminonone and the litchi leaf extract according to the weight ratio of 7.
The antiallergic agent consists of kava kava and melissa extract according to a weight ratio of 7.
The thickening agent is carbomer 941; the pH regulator is triethanolamine.
The preparation method of the hyaluronic acid moisturizing and repairing composition comprises the following steps:
s1, adding carbomer 941 and 1,2 hexanediol into water with the total water volume of 99% and soaking for 24 hours in an emulsifying cylinder with the capacity of 100 kg;
s2, adding glycerol, jasminodone and litchi leaf extract into an emulsifying cylinder filled with carbomer 941 and 1,2 hexanediol soaked in the step S1, heating to 80 ℃ under the stirring condition of 25r/min, preserving the temperature for 20min when the temperature of the emulsifying cylinder reaches 80 ℃, then opening a cooling system of the emulsifying cylinder at a constant speed, continuing stirring, and cooling to 45 ℃ to obtain a component A;
s3, sequentially adding erythritol, propylene glycol and macromolecular sodium hyaluronate into the component A prepared in the step S2, and stirring at the speed of 25r/min for 15min to obtain a component B;
s4, adding kava kava and bee pollen extracts into the component B prepared in the step S3;
s5, dissolving triethanolamine serving as a pH regulator into water according to the proportion to obtain a component C;
s6, adding the component C prepared in the step S5 into the component B prepared in the step S4, stirring for 5min at a constant speed to obtain a component D with pH = 5;
s7, continuously stirring the component D prepared in the step S6 uniformly, stopping stirring to obtain a mask liquid, sampling, detecting and reserving a sample;
and S8, passing the qualified facial mask liquid through a 200-mesh filter screen, and then sealing and storing to obtain the facial mask liquid.
Comparative example 1 is substantially the same as example 3 except that the moisturizer of comparative example 1 uses an equivalent weight part of glycerin instead of allantoin and erythritol instead of low molecular weight sodium hyaluronate.
Comparative example 2 hyaluronic acid moisturizing repair composition
The hyaluronic acid moisturizing and repairing composition consists of the following components in percentage by weight:
3.31 percent of humectant A, 6.95 percent of humectant B, 0.4 percent of preservative, 0.3 percent of antiallergic agent, 0.1 percent of thickening agent, 0.1 percent of pH regulator, 0.64 percent of 1,2 hexanediol and 88.2 percent of water.
The humectant A comprises the following components in parts by weight:
2 parts of allantoin and 60 parts of glycerol;
the humectant B comprises the following components in parts by weight:
120 parts of propylene glycol, 5 parts of macromolecular sodium hyaluronate, 3 parts of low-molecular sodium hyaluronate and 2 parts of erythritol.
The preservative consists of the jasminonone and the litchi leaf extract according to the weight ratio of 1.
The antiallergic agent consists of kava kava and melissa extract according to a weight ratio of 7.
The thickening agent is carbomer 941; the pH regulator is triethanolamine.
The preparation method of the hyaluronic acid moisturizing and repairing composition comprises the following steps:
s1, adding carbomer 941 and 1,2 hexanediol into water with the total water volume of 99% and soaking for 24 hours in an emulsifying cylinder with the capacity of 100 kg;
s2, adding allantoin, glycerol, jasminorange ketone and litchi leaf extract into an emulsifying cylinder containing carbomer 941 and 1,2 hexanediol soaked in the step S1, heating to 80 ℃ under the stirring condition of 25r/min, preserving the temperature for 20min when the temperature of the emulsifying cylinder reaches 80 ℃, then opening a cooling system of the emulsifying cylinder, keeping the speed unchanged, continuing stirring, and cooling to 45 ℃ to obtain a component A;
s3, sequentially adding erythritol, propylene glycol, macromolecular sodium hyaluronate and low-molecular transparent sodium hyaluronate into the component A prepared in the step S2, and stirring at the speed of 25r/min for 15min to obtain a component B;
s4, adding kava kava and melissa extract into the component B prepared in the step S3;
s5, dissolving a pH regulator triethanolamine in water according to the proportion to obtain a component C;
s6, adding the component C prepared in the step S5 into the component B prepared in the step S4, stirring for 5min at a constant speed to obtain a component D with pH = 5;
s7, continuously stirring the component D prepared in the step S6 uniformly, then stopping stirring to obtain a mask liquid, sampling, detecting and reserving a sample;
and S8, passing the qualified facial mask liquid through a 200-mesh filter screen, and then sealing and storing to obtain the facial mask liquid.
Comparative example 2 is essentially the same as example 3 except that the preservative of comparative example 2 consists of jasmone and litchi leaf extract in a weight ratio of 7 to 1 to consist of jasmone and litchi leaf extract in a weight ratio of 1.
Comparative example 3 hyaluronic acid moisturizing repair composition
The hyaluronic acid moisturizing and repairing composition consists of the following components in percentage by weight:
humectant A3.31%, humectant B6.95%, antiseptic 0.4%, antiallergic agent 0.3%, thickener 0.1%, pH regulator 0.1%, 1,2 hexanediol 0.64% and water 88.2%.
The humectant A comprises the following components in parts by weight:
2 parts of allantoin and 60 parts of glycerol;
the humectant B comprises the following components in parts by weight:
120 parts of propylene glycol, 5 parts of macromolecular sodium hyaluronate, 3 parts of low molecular sodium hyaluronate and 2 parts of erythritol.
The preservative is litchi leaf extract.
The antiallergic agent consists of kava kava and melissa officinalis extract according to a weight ratio of 7.
The thickening agent is carbomer 941; the pH regulator is triethanolamine.
The preparation method of the hyaluronic acid moisturizing and repairing composition comprises the following steps:
s1, adding carbomer 941 and 1,2 hexanediol into water with the total water volume of 99% and soaking for 24 hours in an emulsifying cylinder with the capacity of 100 kg;
s2, adding allantoin, glycerol and a litchi leaf extract into an emulsifying cylinder containing the carbomer 941 and 1,2 hexanediol soaked in the step S1, heating to 80 ℃ under the stirring condition of 25r/min, preserving the temperature for 20min when the temperature of the emulsifying cylinder reaches 80 ℃, then opening a cooling system of the emulsifying cylinder, keeping the speed unchanged, continuing stirring, and cooling to 45 ℃ to obtain a component A;
s3, sequentially adding erythritol, propylene glycol, macromolecular sodium hyaluronate and low-molecular transparent sodium hyaluronate into the component A prepared in the step S2, and stirring at the speed of 25r/min for 15min to obtain a component B;
s4, adding kava kava and melissa extract into the component B prepared in the step S3;
s5, dissolving a pH regulator triethanolamine in water according to the proportion to obtain a component C;
s6, adding the component C prepared in the step S5 into the component B prepared in the step S4, stirring for 5min at a constant speed to obtain a component D with pH = 5;
s7, continuously stirring the component D prepared in the step S6 uniformly, stopping stirring to obtain a mask liquid, sampling, detecting and reserving a sample;
and S8, passing the qualified facial mask liquid through a 200-mesh filter screen, and then sealing and storing to obtain the facial mask liquid.
Comparative example 3 is essentially the same as example 3 except that the preservative of comparative example 3 is litchi leaf extract.
Comparative example 4 hyaluronic acid moisturizing repair composition
The hyaluronic acid moisturizing and repairing composition comprises the following components in percentage by weight:
humectant A3.31%, humectant B6.95%, antiseptic 0.4%, antiallergic agent 0.3%, thickener 0.1%, pH regulator 0.1%, 1,2 hexanediol 0.64% and water 88.2%.
The humectant A comprises the following components in parts by weight:
2 parts of allantoin and 60 parts of glycerol;
the humectant B comprises the following components in parts by weight:
120 parts of propylene glycol, 5 parts of macromolecular sodium hyaluronate, 3 parts of low molecular sodium hyaluronate and 2 parts of erythritol.
The antiseptic is menthone.
The antiallergic agent consists of kava kava and melissa officinalis extract according to a weight ratio of 7.
The thickening agent is carbomer 941; the pH regulator is triethanolamine.
The preparation method of the hyaluronic acid moisturizing and repairing composition comprises the following steps:
s1, adding carbomer 941 and 1,2 hexanediol into water with the total water volume of 99% and soaking for 24 hours in an emulsifying cylinder with the capacity of 100 kg;
s2, adding allantoin, glycerol and jasminodin into an emulsifying cylinder filled with the carbomer 941 and 1, 2-hexanediol soaked in the step S1, heating to 80 ℃ under the stirring condition of 25r/min, keeping the temperature for 20min when the temperature of the emulsifying cylinder reaches 80 ℃, then opening a cooling system of the emulsifying cylinder at a constant speed, continuing stirring, and cooling to 45 ℃ to obtain a component A;
s3, sequentially adding erythritol, propylene glycol, macromolecular sodium hyaluronate and low-molecular transparent sodium hyaluronate into the component A prepared in the step S2, and stirring at the speed of 25r/min for 15min to obtain a component B;
s4, adding kava kava and bee pollen extracts into the component B prepared in the step S3;
s5, dissolving a pH regulator triethanolamine in water according to the proportion to obtain a component C;
s6, adding the component C prepared in the step S5 into the component B prepared in the step S4, stirring for 5min at a constant speed to obtain a component D with pH = 5;
s7, continuously stirring the component D prepared in the step S6 uniformly, then stopping stirring to obtain a mask liquid, sampling, detecting and reserving a sample;
and S8, passing the qualified facial mask liquid through a 200-mesh filter screen, and then sealing and storing to obtain the facial mask liquid.
Comparative example 4 is substantially the same as example 3 except that the preservative of comparative example 4 is jasmone.
Comparative example 5 hyaluronic acid moisturizing repair composition
The hyaluronic acid moisturizing and repairing composition comprises the following components in percentage by weight:
humectant A3.31%, humectant B6.95%, antiseptic 0.4%, antiallergic agent 0.3%, thickener 0.1%, pH regulator 0.1%, 1,2 hexanediol 0.64% and water 88.2%.
The humectant A comprises the following components in parts by weight:
2 parts of allantoin and 60 parts of glycerol;
the humectant B comprises the following components in parts by weight:
120 parts of propylene glycol, 5 parts of macromolecular sodium hyaluronate, 3 parts of low-molecular sodium hyaluronate and 2 parts of erythritol.
The preservative consists of the jasminolone and the litchi leaf extract according to the weight ratio of 7.
The antiallergic agent consists of kava kava and melissa officinalis extract according to the weight ratio of 1.
The thickening agent is carbomer 941; the pH regulator is triethanolamine.
The preparation method of the hyaluronic acid moisturizing and repairing composition comprises the following steps:
s1, adding carbomer 941 and 1,2 hexanediol into water with the total water volume of 99% and soaking for 24 hours in an emulsifying cylinder with the capacity of 100 kg;
s2, adding allantoin, glycerol, jasminorange ketone and litchi leaf extract into an emulsifying cylinder containing carbomer 941 and 1,2 hexanediol soaked in the step S1, heating to 80 ℃ under the stirring condition of 25r/min, preserving the temperature for 20min when the temperature of the emulsifying cylinder reaches 80 ℃, then opening a cooling system of the emulsifying cylinder, keeping the speed unchanged, continuing stirring, and cooling to 45 ℃ to obtain a component A;
s3, sequentially adding erythritol, propylene glycol, macromolecular sodium hyaluronate and low-molecular transparent sodium hyaluronate into the component A prepared in the step S2, and stirring at the speed of 25r/min for 15min to obtain a component B;
s4, adding kava kava and melissa extract into the component B prepared in the step S3;
s5, dissolving a pH regulator triethanolamine in water according to the proportion to obtain a component C;
s6, adding the component C prepared in the step S5 into the component B prepared in the step S4, stirring for 5min at a constant speed to obtain a component D with pH = 5;
s7, continuously stirring the component D prepared in the step S6 uniformly, then stopping stirring to obtain a mask liquid, sampling, detecting and reserving a sample;
and S8, passing the qualified facial mask liquid through a 200-mesh filter screen, and then sealing and storing to obtain the facial mask liquid.
Comparative example 5 is substantially the same as example 3 except that the ratio of the anti-allergic agent kava kava and melissa officinalis extract of comparative example 5 is changed from 7 to 1.
Comparative example 6 hyaluronic acid moisturizing and repairing composition
The hyaluronic acid moisturizing and repairing composition consists of the following components in percentage by weight:
humectant A3.31%, humectant B6.95%, antiseptic 0.4%, antiallergic agent 0.3%, thickener 0.1%, pH regulator 0.1%, 1,2 hexanediol 0.64% and water 88.2%.
The humectant A comprises the following components in parts by weight:
2 parts of allantoin and 60 parts of glycerol;
the humectant B comprises the following components in parts by weight:
120 parts of propylene glycol, 5 parts of macromolecular sodium hyaluronate, 3 parts of low-molecular sodium hyaluronate and 2 parts of erythritol.
The preservative consists of the jasminonone and the litchi leaf extract according to the weight ratio of 7.
The antiallergic agent is kava kava.
The thickening agent is carbomer 941; the pH regulator is triethanolamine.
The preparation method of the hyaluronic acid moisturizing and repairing composition comprises the following steps:
s1, adding carbomer 941 and 1,2 hexanediol into water with the total water volume of 99%, and soaking in an emulsion cylinder with the volume of 100kg for 24 hours;
s2, adding allantoin, glycerol, jasminorange ketone and litchi leaf extract into an emulsifying cylinder containing carbomer 941 and 1,2 hexanediol soaked in the step S1, heating to 80 ℃ under the stirring condition of 25r/min, preserving the temperature for 20min when the temperature of the emulsifying cylinder reaches 80 ℃, then opening a cooling system of the emulsifying cylinder, keeping the speed unchanged, continuing stirring, and cooling to 45 ℃ to obtain a component A;
s3, sequentially adding erythritol, propylene glycol, macromolecular sodium hyaluronate and low-molecular transparent sodium hyaluronate into the component A prepared in the step S2, and stirring at the speed of 25r/min for 15min to obtain a component B;
s4, adding kava kava into the component B prepared in the step S3;
s5, dissolving a pH regulator triethanolamine in water according to the proportion to obtain a component C;
s6, adding the component C prepared in the step S5 into the component B prepared in the step S4, stirring for 5min at a constant speed to obtain a component D with pH = 5;
s7, continuously stirring the component D prepared in the step S6 uniformly, stopping stirring to obtain a mask liquid, sampling, detecting and reserving a sample;
and S8, passing the qualified facial mask liquid through a 200-mesh filter screen, and then sealing and storing to obtain the facial mask liquid.
Comparative example 6 is substantially the same as example 3 except that the antiallergic agent of comparative example 6 is kava kava.
Comparative example 7 hyaluronic acid moisturizing and repairing composition
The hyaluronic acid moisturizing and repairing composition consists of the following components in percentage by weight:
3.31 percent of humectant A, 6.95 percent of humectant B, 0.4 percent of preservative, 0.3 percent of antiallergic agent, 0.1 percent of thickening agent, 0.1 percent of pH regulator, 1.04 percent of 1, 2-hexanediol and 88.2 percent of water.
The humectant A comprises the following components in parts by weight:
2 parts of allantoin and 60 parts of glycerol;
the humectant B comprises the following components in parts by weight:
120 parts of propylene glycol, 5 parts of macromolecular sodium hyaluronate, 3 parts of low molecular sodium hyaluronate and 2 parts of erythritol.
The antiallergic agent consists of kava kava and melissa extract according to a weight ratio of 7.
The thickening agent is carbomer 941; the pH regulator is triethanolamine.
The preparation method of the hyaluronic acid moisturizing and repairing composition comprises the following steps:
s1, adding carbomer 941 and 1,2 hexanediol into water with the total water volume of 99% and soaking for 24 hours in an emulsifying cylinder with the capacity of 100 kg;
s2, adding allantoin and glycerol into an emulsifying cylinder filled with the carbomer 941 and the 1, 2-hexanediol soaked in the step S1, heating to 80 ℃ under the stirring condition of 25r/min, preserving the temperature for 20min when the temperature of the emulsifying cylinder reaches 80 ℃, then opening a cooling system of the emulsifying cylinder, keeping the speed unchanged, continuing stirring, and cooling to 45 ℃ to obtain a component A;
s3, sequentially adding erythritol, propylene glycol, macromolecular sodium hyaluronate and low-molecular transparent sodium hyaluronate into the component A prepared in the step S2, and stirring at the speed of 25r/min for 15min to obtain a component B;
s4, adding kava kava and melissa extract into the component B prepared in the step S3;
s5, dissolving a pH regulator triethanolamine in water according to the proportion to obtain a component C;
s6, adding the component C prepared in the step S5 into the component B prepared in the step S4, stirring for 5min at a constant speed to obtain a component D with pH = 5;
s7, continuously stirring the component D prepared in the step S6 uniformly, stopping stirring to obtain a mask liquid, sampling, detecting and reserving a sample;
and S8, passing the qualified facial mask liquid through a 200-mesh filter screen, and then sealing and storing to obtain the facial mask liquid.
Comparative example 7 is essentially the same as example 3, except that the preservative in comparative example 7 is 1,2 hexanediol.
Test example I, skin irritation test
1. Test materials: the hyaluronic acid moisturizing repair compositions prepared in examples 1 to 4 and comparative examples 1 to 6.
2. Test subjects: an artificial skin model.
3. The test method comprises the following steps: human keratinocytes are cultured in a gas-liquid medium on a collagen matrix to form an in vitro reconstructed human epidermal model. The hyaluronic acid moisturizing repair compositions obtained in examples 1 to 4 and comparative examples 1 to 6 were applied to the surface of an artificial skin model, and the results were observed after 15 min.
4. And (3) test results: according to observation, the skin models coated with the facial mask liquids prepared in examples 1 to 4 do not have irritation reactions such as local redness and eruption, while the skin models coated with the facial mask liquids prepared in comparative examples 1 to 6 show that the phenomena of local redness and eruption in different degrees occur, which shows that the hyaluronic acid moisturizing repair composition prepared by the invention is safe, free of irritation and free of any adverse reaction.
Test example two, hyaluronic acid moisturizing repair composition energy efficiency test
1. Test materials: the hyaluronic acid moisturizing repair compositions prepared in examples 1 to 4 and comparative examples 1 to 6 were used.
2. The test method comprises the following steps: the relative moisturizing rate, the skin water content, the heavy metal content, the oxidation resistance and the facial wrinkle relieving degree of the hyaluronic acid moisturizing repair composition adopting the skin barrier capability test method, the electric conduction method, the X-ray fluorescence technology test method, the salicylic acid method and the skin texture test materials are respectively adopted.
3. The experimental results are shown in table 1, wherein the content of heavy metal is as follows: mercury is less than or equal to 1mg/kg, arsenic is less than or equal to 10mg/kg, and lead is less than or equal to 40mg/kg.
Table 1 moisturizing and anti-wrinkle mask stock solution energy efficiency test results
As is clear from Table 1, examples 1, and 6 show that the hyaluronic acid moisturizing repair compositions prepared in the comparative examples 1 to 6,
The hyaluronic acid moisturizing and repairing compositions prepared in examples 2, 3 and 4 have higher relative moisturizing rate and skin water content, lower heavy metal content and better oxidation resistance and skin repairing performance, wherein the comprehensive performance of the hyaluronic acid moisturizing and repairing composition prepared in example 3 is the best, and the result shows that the hyaluronic acid moisturizing and repairing composition prepared in the invention has good moisturizing, anti-wrinkle, repairing and oxidation resistance performances.
The foregoing embodiments are merely illustrative of the principles and utilities of the present invention and are not intended to limit the invention. Those skilled in the art can modify or change the above-described embodiments without departing from the spirit and scope of the present invention. Accordingly, it is intended that all equivalent modifications or changes which may be made by those skilled in the art without departing from the spirit and scope of the present invention as defined in the appended claims.
Claims (8)
1. The hyaluronic acid moisturizing and repairing composition is characterized by comprising the following components in percentage by weight: 0.84 to 6.08 percent of humectant A, 2.24 to 9.63 percent of humectant B, 0.1 to 0.6 percent of preservative, 0.1 to 0.8 percent of antiallergic agent, 0.03 to 0.13 percent of thickening agent, 0.03 to 0.13 percent of pH regulator, 0.13 to 1.18 percent of 1, 2-hexanediol and 81.45 to 96.53 percent of water;
the humectant A comprises the following components in parts by weight: 1-3 parts of allantoin and 30-100 parts of glycerol; the humectant B comprises the following components in parts by weight: 80-150 parts of propylene glycol, 1-6 parts of macromolecular sodium hyaluronate, 1-4 parts of low molecular sodium hyaluronate and 1-3 parts of erythritol; the molecular weight of the macromolecular sodium hyaluronate is 100-170 ten thousand Da, and the molecular weight of the low molecular sodium hyaluronate is 28-80 ten thousand Da;
the preservative consists of jasminonone and litchi leaf extract according to the weight ratio of 5-9; the antiallergic agent comprises dried root extract of kava of Piperaceae and Melissa officinalis extract at a weight ratio of 2-3.
2. The hyaluronic acid moisturizing repair composition of claim 1, consisting of the following components and weight percentages thereof: 3.31 percent of humectant A, 6.95 percent of humectant B, 0.4 percent of preservative, 0.3 percent of antiallergic agent, 0.1 percent of thickening agent, 0.1 percent of pH regulator, 0.64 percent of 1, 2-hexanediol and 88.2 percent of water;
the humectant A comprises the following components in parts by weight: 2 parts of allantoin and 60 parts of glycerol; the humectant B comprises the following components in parts by weight: 120 parts of propylene glycol, 5 parts of macromolecular sodium hyaluronate, 3 parts of low-molecular sodium hyaluronate and 2 parts of erythritol.
3. The hyaluronic acid moisturizing repair composition of claim 1, wherein the preservative consists of jasmone and litchi leaf extract in a weight ratio of 7.
4. The hyaluronic acid moisturizing repair composition of claim 1, wherein the antiallergic agent consists of a dried root extract of kava of the family Piperaceae and Melissa officinalis extract in a weight ratio of 7.
5. The moisturizing hyaluronic acid repair composition of claims 1 or 2, wherein the thickening agent is carbomer 941; the pH regulator is triethanolamine.
6. The application of the hyaluronic acid moisturizing and repairing composition as defined in any one of claims 1-5 in preparation of stock solutions and emulsions of cold application masks.
7. The method for preparing the hyaluronic acid moisturizing repair composition of claim 5, comprising the steps of:
s1, adding carbomer 941 and 1, 2-hexanediol into water, and soaking in an emulsifying cylinder for 12-24 hours;
s2, adding the humectant A and the preservative into an emulsification tank filled with the carbomer 941 and the 1, 2-hexanediol soaked in the step S1, stirring, heating to 80-100 ℃, keeping the temperature for 20-40min, then opening a cooling system of the emulsification tank, keeping the stirring speed unchanged, continuing stirring, and cooling to 40-50 ℃ to obtain a mixture A;
s3, adding the components in the humectant B into the mixture A prepared in the step S2, and stirring to obtain a mixture B;
s4, adding an antiallergic agent into the mixture B prepared in the step S3;
s5, dissolving triethanolamine in water according to the proportion to obtain a mixture C;
s6, adding the mixture C obtained in the step S5 into the mixture B obtained in the step S4, stirring for 5-10min at a constant stirring speed to obtain a mixture D with pH = 4.5-6.5;
s7, continuously stirring the mixture D prepared in the step S6 uniformly, stopping stirring to obtain a mask liquid, sampling, detecting and reserving a sample;
and S8, filtering the qualified mask liquid filter screen, and sealing and storing to obtain the mask liquid filter screen.
8. The method of claim 7, comprising the steps of:
s1, adding carbomer 941 and 1, 2-hexanediol into water with the total water volume of 99%, and soaking in an emulsifying cylinder with the capacity of 100kg for 24 hours;
s2, adding the humectant A and the preservative into an emulsifying cylinder filled with the carbomer 941 and the 1, 2-hexanediol soaked in the step S1, heating to 80 ℃ under the stirring condition of 25r/min, keeping the temperature for 20min when the temperature of the emulsifying cylinder reaches 80 ℃, then opening a cooling system of the emulsifying cylinder, keeping the stirring speed unchanged, continuing stirring, and cooling to 45 ℃ to obtain a mixture A;
s3, adding the components in the humectant B into the mixture A prepared in the step S2, and stirring at the speed of 25r/min for 15min to obtain a mixture B;
s4, adding an antiallergic agent into the mixture B prepared in the step S3;
s5, dissolving triethanolamine in water according to the proportion to obtain a mixture C;
s6, adding the mixture C obtained in the step S5 into the mixture B obtained in the step S4, stirring for 5min at a constant stirring speed to obtain a mixture D with pH = 4.5-6.5;
s7, continuously stirring the mixture D prepared in the step S6 uniformly, then stopping stirring to obtain a mask liquid, sampling, detecting and reserving a sample;
and S8, passing the qualified facial mask liquid through a 200-mesh filter screen, and then sealing and storing to obtain the facial mask liquid.
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| US8722854B2 (en) * | 2010-12-23 | 2014-05-13 | Medskin Solutions Dr. Suwelack Ag | Degradation-stabilised, biocompatible collagen matrices |
| KR102076480B1 (en) * | 2015-08-10 | 2020-02-13 | 에보닉 오퍼레이션스 게엠베하 | Positively Charged Sugar Emulsifier Based Skin Permeability Delivery System |
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| CN109364124A (en) * | 2018-12-14 | 2019-02-22 | 广州艾蓓生物科技有限公司 | It is a kind of spraying and preparation method thereof with sedative-hypnotic property |
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