CN106581741A - Reconstructed human source collagen paste and preparation method thereof - Google Patents
Reconstructed human source collagen paste and preparation method thereof Download PDFInfo
- Publication number
- CN106581741A CN106581741A CN201611224479.2A CN201611224479A CN106581741A CN 106581741 A CN106581741 A CN 106581741A CN 201611224479 A CN201611224479 A CN 201611224479A CN 106581741 A CN106581741 A CN 106581741A
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- CN
- China
- Prior art keywords
- human source
- collagen
- source collagen
- menthol
- reconstructed human
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0066—Medicaments; Biocides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0028—Polypeptides; Proteins; Degradation products thereof
- A61L26/0033—Collagen
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L89/00—Compositions of proteins; Compositions of derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/45—Mixtures of two or more drugs, e.g. synergistic mixtures
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/04—Materials for stopping bleeding
Abstract
The invention provides a reconstructed human source collagen paste and a preparation method thereof and relates to the technical field of skin discomfort dose. The formula of the reconstructed human source collagen paste includes the following materials by weight percent: 0.5%-25% of reconstructed human source collagen, 1.5%-10% of sophora flavescens, 0.8%-8.0% of gallnut, 0.1%-1.0% of menthol, 2.0%-5.0% of ethyl alcohol and the balance of water. The preparation method comprises the following steps: dissolving the reconstructed human source collagen in water and uniformly stirring, thereby acquiring a collagen aqueous solution; dissolving the menthol in ethyl alcohol, thereby acquiring a menthol solution; slicing the sophora flavescens and the gallnut, and then baking under high temperature and milling into powder; adding the menthol solution and the sophora flavescens and gallnut powder into the collagen aqueous solution and quickly stirring, thereby acquiring a suspension; quickly freezing the suspension at -50 DEG C to -80 DEG C, freeze-drying and then acquiring the reconstructed human source collagen paste for skin discomfort. The reconstructed human source collagen paste has the advantages of convenience in use, safety, effectiveness, no irritation to skin due to the pure traditional Chinese medicine ingredients and suitability for long-term use.
Description
Technical field
The present invention relates to skin discomfort medicine-feeding technology field, and in particular to a kind of recombination human source collagen uncomfortable for skin
Albumen dressing and preparation method thereof.
Background technology
Collagen and its modified product can promote the immigration and growth of epidermal cell, beneficial to wound healing, significantly shorten
Healing time, in being largely used to the production of dressing.But animal sources collagen poorly water-soluble, wide material sources and homogeneity
Differ from, there is viral infection risk and be easily caused patient and produce the defects such as allergy so that it is restricted in clinical practice.
In Clinical practice, for the symptoms such as skin discomfort are used mostly gel, but gel smears inequality, it is easy to clothing
Thing etc. is adhered to, and is made troubles to patient.
Therefore, research is needed in a kind of uncomfortable for skin, collagen dressing that immunological rejection is little badly.Recombination human source collagen
Albumen good water solubility, the advantages of can improve the compatibility with skin, virus-free residual, non-sensitization, is more and more studied.
The content of the invention
It is an object of the invention to provide a kind of easy to use, safe effective, pure Chinese medicine composition is adapted to no skin irritation
Long-Time Service, has the effect that significantly inhibits to streptococcus etc., eliminates the uncomfortable recombination human source collagen of skin caused by many factors
Albumen dressing and preparation method thereof.
In order to solve the problems of background technology, the present invention is to employ the following technical solutions：A kind of recombination human source glue
Former albumen dressing, its mass ratio formula is consisted of：
A kind of preparation method of recombination human source collagen dressing, comprises the following steps：
1. it is recombination human source collagen is soluble in water, stir, obtain collagen aqueous solution；2. it is menthol is molten
In ethanol, menthol solution is obtained；3. high temperature after kuh-seng and Chinese gall section is bakeed, grinds to form smalls；4. by menthol
Solution and kuh-seng, Chinese gall smalls are added in collagen aqueous solution, and high-speed stirred is obtained suspension；5. by suspension in -50
DEG C～-80 DEG C it is quick-frozen, freeze-drying is obtained for the uncomfortable recombination human source collagen dressing of skin.
The present invention is uncomfortable for eliminating various skins.
After using above-mentioned technical proposal, the invention has the advantages that：
1st, recombination human source collagen is adopted to prepare dressing for timbering material.Recombination human source collagen biologically active height,
Good hydrophilic property, can significantly improve the reparation speed of skin, and virus-free residual, without sensitization, can Long-Time Service；
2nd, kuh-seng can have good mitigation to the pruitus that a variety of causes causes with sterilizing and itch-relieving, promote skin
Repair；
3rd, tannic acid component contained in Chinese gall has precipitation to the protein in skin, and to streptococcus, grape ball
Bacterium has obvious inhibiting effect, in being widely used in the uncomfortable treatment of skin；
4th, appropriate menthol has refrigerant itching-relieving action；
5th, easy to use, safe effective, pure Chinese medicine composition is adapted to Long-Time Service to no skin irritation.
Specific embodiment
In order that the objects, technical solutions and advantages of the present invention become more apparent, it is right below in conjunction with specific embodiment
The present invention is further elaborated.It should be appreciated that specific embodiment described herein is only to explain the present invention, and
It is not used in the restriction present invention.
This specific embodiment is employed the following technical solutions：A kind of recombination human source collagen dressing, its mass ratio is matched somebody with somebody
Side consists of：
A kind of preparation method of recombination human source collagen dressing, comprises the following steps：
1. appropriate recombination human source collagen is soluble in water, stirs, and obtains collagen aqueous solution；2. will be appropriate thin
Lotus brain is dissolved in ethanol, obtains menthol solution；3. high temperature after appropriate kuh-seng and Chinese gall section is bakeed, is ground to form thin
End；4. menthol solution and kuh-seng, Chinese gall smalls are added in collagen aqueous solution, high-speed stirred is obtained suspension；⑤
Suspension is quick-frozen in -50 DEG C～-80 DEG C, and freeze-drying is obtained for the uncomfortable recombination human source collagen dressing of skin.
Below in conjunction with specific embodiment, the present invention will be described in further detail：
Embodiment 1：
A kind of recombination human source collagen dressing, including each component of following mass ratio：
A kind of preparation method of recombination human source collagen dressing, comprises the following steps：1. by 25% recombination human source collagen
Albumen is soluble in water, stirs, and obtains collagen aqueous solution；2. 0.1% menthol is dissolved in ethanol, obtains menthol
Solution；3. high temperature after 10% kuh-seng and the section of 0.8% Chinese gall is bakeed, grinds to form smalls；4. by menthol solution and kuh-seng,
Chinese gall smalls is added in collagen aqueous solution, and high-speed stirred is obtained suspension；5. it is suspension is quick-frozen in -50 DEG C, freezing
Drying is obtained for the uncomfortable recombination human source collagen dressing of skin.
Embodiment 2：
A kind of recombination human source collagen dressing, including each component of following mass ratio：
A kind of preparation method of recombination human source collagen dressing, comprises the following steps：1. by 15% recombination human source collagen
Albumen is soluble in water, stirs, and obtains collagen aqueous solution；2. 0.5% menthol is dissolved in ethanol, obtains menthol
Solution；3. high temperature after 1.5% kuh-seng and the section of 8.0% Chinese gall is bakeed, grinds to form smalls；4. by menthol solution and hardship
Ginseng, Chinese gall smalls are added in collagen aqueous solution, and high-speed stirred is obtained suspension；5. it is suspension is quick-frozen in -80 DEG C, it is cold
Freeze dry being obtained for the uncomfortable recombination human source collagen dressing of skin.
Embodiment 3：
A kind of recombination human source collagen dressing, including each component of following mass ratio：
A kind of preparation method of recombination human source collagen dressing, comprises the following steps：1. by 25% recombination human source collagen
Albumen is soluble in water, stirs, and obtains collagen aqueous solution；2. 1.0% menthol is dissolved in ethanol, obtains menthol
Solution；3. high temperature after 5.0% kuh-seng and the section of 8.0% Chinese gall is bakeed, grinds to form smalls；4. by menthol solution and hardship
Ginseng, Chinese gall smalls are added in collagen aqueous solution, and high-speed stirred is obtained suspension；5. it is suspension is quick-frozen in -60 DEG C, it is cold
Freeze dry being obtained for the uncomfortable recombination human source collagen dressing of skin.
Embodiment 4：
A kind of recombination human source collagen dressing, including each component of following mass ratio：
A kind of preparation method of recombination human source collagen dressing, comprises the following steps：1. by 5.0% recombination human source collagen
Albumen is soluble in water, stirs, and obtains collagen aqueous solution；2. 0.2% menthol is dissolved in ethanol, obtains menthol
Solution；3. high temperature after 10% kuh-seng and the section of 5.0% Chinese gall is bakeed, grinds to form smalls；4. by menthol solution and hardship
Ginseng, Chinese gall smalls are added in collagen aqueous solution, and high-speed stirred is obtained suspension；5. it is suspension is quick-frozen in -50 DEG C, it is cold
Freeze dry being obtained for the uncomfortable recombination human source collagen dressing of skin.
Embodiment 5：Clinical research
Clinical medicine：Prepare by the preparation method of above-mentioned dressing embodiments；Dosage：A daily patch, is a treatment in 7 days
Journey.
Physical data：Collection is gone to a doctor in the patient 55 uncomfortable with skins such as eczemas of hospital dermatology department for 2016.
Tracking, statistics patient's recovery situation.
Clinical effectiveness：After two courses for the treatment of in 55 patients, fully recover 41, effective 12, invalid 2, total effective rate 96%,
Cure rate 74.5%.
Conclusion：The recombination human source collagen dressing of the present invention is made for the skins such as eczema are uncomfortable with good treatment
With.
It is obvious to a person skilled in the art that the invention is not restricted to the details of above-mentioned one exemplary embodiment, Er Qie
In the case of spirit or essential attributes without departing substantially from the present invention, the present invention can be in other specific forms realized.Therefore, no matter
From the point of view of which point, embodiment all should be regarded as exemplary, and be nonrestrictive, the scope of the present invention is by appended power
Profit is required rather than described above is limited, it is intended that all in the implication and scope of the equivalency of claim by falling
Change is included in the present invention.
Moreover, it will be appreciated that although this specification is been described by according to embodiment, not each embodiment is only wrapped
Containing an independent technical scheme, this narrating mode of specification is only that for clarity those skilled in the art should
Using specification as an entirety, the technical scheme in each embodiment can also Jing it is appropriately combined, form those skilled in the art
Understandable other embodiment.
Claims (2)
1. a kind of recombination human source collagen dressing, it is characterised in that its mass ratio formula is consisted of：
2. a kind of preparation method of recombination human source collagen dressing, it is characterised in that comprise the following steps：
1. it is recombination human source collagen is soluble in water, stir, obtain collagen aqueous solution；2. menthol is dissolved in into second
In alcohol, menthol solution is obtained；3. high temperature after kuh-seng and Chinese gall section is bakeed, grinds to form smalls；4. by menthol solution
Add in collagen aqueous solution with kuh-seng, Chinese gall smalls, high-speed stirred is obtained suspension；5. by suspension in -50 DEG C～-
80 DEG C quick-frozen, and freeze-drying is obtained for the uncomfortable recombination human source collagen dressing of skin.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611224479.2A CN106581741A (en) | 2016-12-27 | 2016-12-27 | Reconstructed human source collagen paste and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611224479.2A CN106581741A (en) | 2016-12-27 | 2016-12-27 | Reconstructed human source collagen paste and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106581741A true CN106581741A (en) | 2017-04-26 |
Family
ID=58604208
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611224479.2A Pending CN106581741A (en) | 2016-12-27 | 2016-12-27 | Reconstructed human source collagen paste and preparation method thereof |
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| Country | Link |
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| CN (1) | CN106581741A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112675353A (en) * | 2020-12-30 | 2021-04-20 | 江苏聚源医疗技术有限公司 | Recombinant collagen dressing and preparation method thereof |
| CN112754763A (en) * | 2020-12-30 | 2021-05-07 | 江苏聚源医疗技术有限公司 | Method for rapidly preparing collagen ice balls by liquid nitrogen freezing |
| CN114832140A (en) * | 2022-05-06 | 2022-08-02 | 江苏益仁堂生物科技有限公司 | Medical skin repair dressing formula |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4564471B2 (en) * | 2006-07-06 | 2010-10-20 | 株式会社コーセー | Composition suitable for external use |
| CN104667335A (en) * | 2015-01-27 | 2015-06-03 | 山西锦波生物医药股份有限公司 | Recombinant human-derived collagen product for skin barrier function or haemorrhoids and preparation method |
| CN105362197A (en) * | 2015-12-16 | 2016-03-02 | 广州市中通生化制品有限公司 | Acne-removing and moisture-preserving facial mask powder containing Chinese herb extract and preparation method of acne-removing and moisture-preserving facial mask powder |
-
2016
- 2016-12-27 CN CN201611224479.2A patent/CN106581741A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4564471B2 (en) * | 2006-07-06 | 2010-10-20 | 株式会社コーセー | Composition suitable for external use |
| CN104667335A (en) * | 2015-01-27 | 2015-06-03 | 山西锦波生物医药股份有限公司 | Recombinant human-derived collagen product for skin barrier function or haemorrhoids and preparation method |
| CN105362197A (en) * | 2015-12-16 | 2016-03-02 | 广州市中通生化制品有限公司 | Acne-removing and moisture-preserving facial mask powder containing Chinese herb extract and preparation method of acne-removing and moisture-preserving facial mask powder |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112675353A (en) * | 2020-12-30 | 2021-04-20 | 江苏聚源医疗技术有限公司 | Recombinant collagen dressing and preparation method thereof |
| CN112754763A (en) * | 2020-12-30 | 2021-05-07 | 江苏聚源医疗技术有限公司 | Method for rapidly preparing collagen ice balls by liquid nitrogen freezing |
| CN114832140A (en) * | 2022-05-06 | 2022-08-02 | 江苏益仁堂生物科技有限公司 | Medical skin repair dressing formula |
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| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20170426 |
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