CN105726366B - Sebum film remediation composition - Google Patents
Sebum film remediation composition Download PDFInfo
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- CN105726366B CN105726366B CN201610214951.8A CN201610214951A CN105726366B CN 105726366 B CN105726366 B CN 105726366B CN 201610214951 A CN201610214951 A CN 201610214951A CN 105726366 B CN105726366 B CN 105726366B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8147—Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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Abstract
The invention discloses a kind of sebum film remediation composition, sebum film maintenance composition is made up of following raw materials by mass percentage：Sodium Hyaluronate 0.1% 1%, trehalose 0.2% 4%, glycerine 2% 15%, at least one of shea butter and Butyrospermum parkii fruit fat 1% 10%, Sodium Polyacrylate 0.1% 0.5% and water 69.5% 96.6%.Experiment proves, the sebum film remediation composition of the present invention, effectively remissive treatment it can change redness after the beauty means such as skin caused by skin, heat pain via laser beautifying, tartaric acid, take off the symptoms such as skin, itch, assimilation effect is good, and gel of the invention is not added with emulsifying agent, belong to non-emulsified system, the risk of sensitization is reduced, and preparation method is simple, it is with short production cycle, prescription is simplified, and cost is low.
Description
Technical field
The invention belongs to biomedicine technical field, is specifically related to a kind of sebum film remediation composition and containing this group
The preparation of compound.
Background technology
Two during the last ten years, and with deepening continuously for China's reform and opening-up, medical shaping and beauty industry is a dark horse, and development is fast
Speed, market is vigorous not to wane.21 century beauty is already required into the life of young women.2014, beauty mechanism of China
The overall market capacity has reached 553,000,000,000 yuan, wherein medical shaping and beauty market accounts for 3.8% share, i.e. medical shaping in 2014
Beauty industry whole nation total quantity consumed breaks through 21,000,000,000 yuan.Recent years, Chinese people are more and more stronger to beautiful and fashion pursuit
Strong, China's beauty industry will also persistently keep rapid growth situation.
The cardinal principle of laser beautifying employ it is beneficial to human body, through ability compared with it is strong, tissue absorptivity is high
Light-wave band, the stimulation using weak laser to biological tissue, facial meridian point is effectively stimulated, accelerates blood circulation,
Improve the supply condition of skin, increase skin tissue's nutrition, promote the anabolism and tissue repair of human body, so as to improve face
The colour of skin is dark and gloomy, pigmentation, cutis laxa, wrinkle, pouch are sagging, livid ring around eye, the thick, pachylosis of pore etc., makes facial skin
The ruddy gloss of skin, elasticity strengthen, the aging of delaying skin, play the effect of skin maintenance.But the problem of following, also exist
These women compatriot to like to be beautiful are annoying, cause skin barrier to be damaged after laser beautifying, and then the symptoms such as red, swollen, hot, pain occur
Annoying these women compatriot.
The patent No. 200510042021.0《For the trehalose of cosmetics and hyaluronic acid compositions and preparation method thereof》
A kind of composition of the trehalose available for cosmetics and hyaluronic acid is disclosed, and only illustrates that said composition has replenishing water and preserving moisture
Effect, the optimal use ratio of said composition, the Sodium Hyaluronate effect of which kind of molecular weight is more preferable and said composition its
He acts on undisclosed.
The content of the invention
The purpose of the present invention is overcome the deficiencies in the prior art, there is provided a kind of sebum film remediation composition.
Second object of the present invention is to provide a kind of gel containing sebum film remediation composition.
Technical scheme is summarized as follows：
Sebum film maintenance composition, is made up of following raw materials by mass percentage：Sodium Hyaluronate 0.1%-1%, marine alga
Sugared 0.2%-4%, glycerine 2%-15%, at least one of shea butter and Butyrospermum parkii fruit fat 1%-10%, polyacrylic acid
Sodium 0.1%-0.5% and water 69.5%-96.6%.
Preferably, Sodium Hyaluronate is 1 by mass ratio:(2~5):The molecular weight ranges of (5~30) 1000000~
2000000 macromolecule Sodium Hyaluronate, the middle numerator sodium hyaluronate and molecule of molecular weight ranges 100000~400000
The micromolecule hyaluronic acid sodium that scope is measured 5000~10000 forms.
Gel containing above-mentioned sebum film maintenance composition, is made of following methods：
(1) Sodium Hyaluronate, Sodium Polyacrylate are well mixed with glycerine；
(2) trehalose is mixed with water, dissolves trehalose, obtain aqueous trehalose solution；
(3) mixture for preparing step (1) is added in aqueous trehalose solution, is heated to 80-90 DEG C, adds shea butter
At least one of with Butyrospermum parkii fruit fat, stir 10-30 minutes；
(4) 30-40 DEG C is cooled to, is produced.
It is demonstrated experimentally that the sebum film remediation composition of the present invention, effectively can be changed remissive treatment via laser beautifying, tartaric acid
Redness after the beauty means such as skin caused by skin, heat pain, the symptoms such as skin, itch are taken off, assimilation effect is good, and gel of the invention does not add
Add emulsifying agent, belong to non-emulsified system, reduce the risk of sensitization, and preparation method is simple, with short production cycle, prescription essence
Letter, cost are low.
Embodiment
With reference to specific embodiment, the present invention is further illustrated.
Embodiment 1
A kind of sebum film remediation composition, it is made up by quality of following components：Sodium Hyaluronate 0.1%, trehalose
0.2%, glycerine 2%, shea butter 1%, Sodium Polyacrylate 0.1% and water 96.6%.
The hyaluronic acid of the present embodiment is 1 by mass ratio:2:30 molecular weight ranges 1000000~1200000 it is big
Molecular weight hyaluronic acid, the middle molecular weight hyaluronic acid and molecular weight ranges of molecular weight ranges 300000~400000 5000~
7000 micromolecule hyaluronic acid composition.
Embodiment 2
A kind of sebum film remediation composition, it is made up by quality of following components：Sodium Hyaluronate 1%, trehalose 4% are sweet
Oil 15%, 10% in Butyrospermum parkii fruit fat, Sodium Polyacrylate 0.5% and water 69.5%.
The hyaluronic acid of the present embodiment is 1 by mass ratio:5:5 molecular weight ranges are at big point of 1800000~2000000
Son amount hyaluronic acid, molecular weight ranges 100000~200000 middle molecular weight hyaluronic acid and molecular weight ranges 8000~
10000 micromolecule hyaluronic acid composition.
Embodiment 3
A kind of sebum film remediation composition, it is made up by quality of following components：Sodium Hyaluronate 0.3%, trehalose 2%,
Glycerine 10%, totally 3% (Butyrospermum parkii fruit fat is 1 with shea butter mass ratio for Butyrospermum parkii fruit fat and shea butter：1), gather
PAA 0.1% and water 84.6%.
The hyaluronic acid of the present embodiment is 1 by mass ratio:4:15 molecular weight ranges 1400000~1600000 it is big
Molecular weight hyaluronic acid, molecular weight ranges 200000~300000 middle molecular weight hyaluronic acid and molecular weight ranges 7000~
8000 micromolecule hyaluronic acid composition.
Embodiment 4
A kind of sebum film remediation composition, it is made up by quality of following components：Sodium Hyaluronate 0.5%, trehalose 1%,
Glycerine 7%, totally 7% (Butyrospermum parkii fruit fat is 2 with shea butter mass ratio for Butyrospermum parkii fruit fat and shea butter：3), poly- third
Olefin(e) acid sodium 0.2% and water 84.3%.
The hyaluronic acid of the present embodiment is 1 by mass ratio:3:22 molecular weight ranges 1700000~1800000 it is big
Molecular weight hyaluronic acid, the middle molecular weight hyaluronic acid and molecular weight ranges of molecular weight ranges 200000~400000 6000~
8000 micromolecule hyaluronic acid composition.
Embodiment 5
Gel containing sebum film remediation composition, it is made of following methods：
(1) each raw material is taken by embodiment 1；
(2) Sodium Hyaluronate, Sodium Polyacrylate are well mixed with glycerine；
(3) trehalose is mixed with water, dissolves trehalose, obtain aqueous trehalose solution；
(4) mixture for preparing step (2) is added in aqueous trehalose solution, is heated to 80 DEG C, is added shea butter, is stirred
Mix 10 minutes；
(5) 40 DEG C are cooled to, is produced.
Embodiment 6
Gel containing sebum film remediation composition, it is made of following methods：
(1) each raw material is taken by embodiment 2；
(2) Sodium Hyaluronate, Sodium Polyacrylate are well mixed with glycerine；
(3) trehalose is mixed with water, dissolves trehalose, obtain aqueous trehalose solution；
(4) mixture for preparing step (2) is added in aqueous trehalose solution, is heated to 90 DEG C, adds Butyrospermum parkii fruit
Fat, stir 10 minutes；
(5) 30 DEG C are cooled to, is produced.
Embodiment 7
Gel containing sebum film remediation composition, it is made of following methods：
(1) each raw material is taken by embodiment 3；
(2) Sodium Hyaluronate, Sodium Polyacrylate are well mixed with glycerine；
(3) trehalose is mixed with water, dissolves trehalose, obtain aqueous trehalose solution；
(4) mixture for preparing step (2) is added in aqueous trehalose solution, is heated to 85 DEG C, add shea butter and
Butyrospermum parkii fruit fat, stir 20 minutes；
(5) 35 DEG C are cooled to, is produced.
Embodiment 8
Gel containing sebum film remediation composition, it is made of following methods：
(1) each raw material is taken by embodiment 4；
(2) Sodium Hyaluronate, Sodium Polyacrylate are well mixed with glycerine；
(3) trehalose is mixed with water, dissolves trehalose, obtain aqueous trehalose solution；
(4) mixture for preparing step (2) is added in aqueous trehalose solution, is heated to 82 DEG C, add shea butter and
Butyrospermum parkii fruit fat, stir 30 minutes；
(5) 32 DEG C are cooled to, is produced.
Experiment：
Comparison liquid used in following experiments and preparation method thereof is as follows：
Compare 1 group：By taking embodiment 1 in Chinese patent ZL200510042021.0 as an example, by trehalose 1.5g, hyaluronic acid
Sodium 0.2g (inventor has found through retrieval, 2005 and in the past, between the molecular weight of Sodium Hyaluronate is 500000 to 2000000,
The Sodium Hyaluronate of this molecular weight section is chosen in the preparation of this comparison liquid), tween 0.2g, ethyl hydroxy benzoate 0.03g be dissolved in 98g water
In, obtain solution.
Compare 2 groups：
(1) take：0.3g hyaluronic acids (are 1 by mass ratio:4:15 molecular weight ranges 1400000~1600000 it is big
Molecular weight hyaluronic acid, the middle molecular weight hyaluronic acid and molecular weight ranges of molecular weight ranges 200000~300000 7000~
8000 micromolecule hyaluronic acid composition), 10g glycerine, Butyrospermum parkii fruit fat and the common 3g of shea butter (Butyrospermum parkii fruit fat with it is newborn
Wooden fruit oil quality ratio is 1：1), Sodium Polyacrylate 0.1g and water 86.6g.
(2) Sodium Hyaluronate, Sodium Polyacrylate are well mixed with glycerine；
(3) mixture prepared by step (2) is added to the water, is heated to 85 DEG C, add shea butter and Butyrospermum parkii fruit
Fat, stir 20 minutes；
(4) 35 DEG C are cooled to, is produced.
Compare 3 groups
(1) trehalose 2g, glycerine 10g, Butyrospermum parkii fruit fat and the common 3g of shea butter (Butyrospermum parkii fruit fat and the wooden fruit of breast are taken
Oil quality ratio is 1：1), Sodium Polyacrylate 0.1g and water 84.9g.
(2) Sodium Polyacrylate is well mixed with glycerine；
(3) trehalose is mixed with water, dissolves trehalose, obtain aqueous trehalose solution；
(4) mixture for preparing step (2) is added in aqueous trehalose solution, is heated to 85 DEG C, add shea butter and
Butyrospermum parkii fruit fat, stir 20 minutes；
(5) 35 DEG C are cooled to, is produced.
Compare 4 groups
(1) take：0.3g molecular weight be 1400000~1600000 Sodium Hyaluronate, 2g trehaloses, 10g glycerine, butter
(Butyrospermum parkii fruit fat is 1 with shea butter mass ratio to fruit tree fruit fat with the common 3g of shea butter：1), Sodium Polyacrylate 0.1g and
Water 84.6g；
(2) Sodium Hyaluronate, Sodium Polyacrylate are well mixed with glycerine；
(3) trehalose is mixed with water, dissolves trehalose, obtain aqueous trehalose solution；
(4) mixture for preparing step (2) is added in aqueous trehalose solution, is heated to 85 DEG C, add shea butter and
Butyrospermum parkii fruit fat, stir 20 minutes；
(5) 35 DEG C are cooled to, is produced.
Compare 5 groups
(1) take：0.3g molecular weight be 200000~300000 Sodium Hyaluronate, 2g trehaloses, 10g glycerine, butter fruit
Setting fruit fat, (Butyrospermum parkii fruit fat is 1 with shea butter mass ratio with the common 3g of shea butter：1), Sodium Polyacrylate 0.1g and water
84.6g；
(2) Sodium Hyaluronate, Sodium Polyacrylate are well mixed with glycerine；
(3) trehalose is mixed with water, dissolves trehalose, obtain aqueous trehalose solution；
(4) mixture for preparing step (2) is added in aqueous trehalose solution, is heated to 85 DEG C, add shea butter and
Butyrospermum parkii fruit fat, stir 20 minutes；
(5) 35 DEG C are cooled to, is produced.
Compare 6 groups
(1) take：0.3g molecular weight be 6000~8000 Sodium Hyaluronate, 2g trehaloses, 10g glycerine, Butyrospermum parkii fruit
(Butyrospermum parkii fruit fat is 1 with shea butter mass ratio to fat with the common 3g of shea butter：1), Sodium Polyacrylate 0.1g and water
84.6g；
(2) Sodium Hyaluronate, Sodium Polyacrylate are well mixed with glycerine；
(3) trehalose is mixed with water, dissolves trehalose, obtain aqueous trehalose solution；
(4) mixture for preparing step (2) is added in aqueous trehalose solution, is heated to 85 DEG C, add shea butter and
Butyrospermum parkii fruit fat, stir 20 minutes；
(5) 35 DEG C are cooled to, is produced.
Compare 7 groups
(1) take：(mass ratio of middle-molecular-weihydroxyethyl Sodium Hyaluronate and macromolecule Sodium Hyaluronate is 0.3g Sodium Hyaluronates
3:1, the molecular weight of middle-molecular-weihydroxyethyl Sodium Hyaluronate is 300000-400000, and the molecular weight of macromolecule Sodium Hyaluronate is
1000000-1200000), 2g trehaloses, 17g glycerine, Butyrospermum parkii fruit fat and the common 3g of shea butter (Butyrospermum parkii fruit fat and breast
Wooden fruit oil quality ratio is 1：1), Sodium Polyacrylate 0.1g and water 80.6g；
(2) Sodium Hyaluronate, Sodium Polyacrylate are well mixed with glycerine；
(3) trehalose is mixed with water, dissolves trehalose, obtain aqueous trehalose solution；
(4) mixture for preparing step (2) is added in aqueous trehalose solution, is heated to 85 DEG C, add shea butter and
Butyrospermum parkii fruit fat, stir 20 minutes；
(5) 35 DEG C are cooled to, is produced.
Compare 8 groups
(1) take：(mass ratio of macromolecule Sodium Hyaluronate and small-molecular-weight Sodium Hyaluronate is 0.3g Sodium Hyaluronates
4:13, the molecular weight of macromolecule Sodium Hyaluronate is 1200000-1400000, and the molecular weight of small-molecular-weight Sodium Hyaluronate is
5000-6000), 2g trehaloses, 10g glycerine, Butyrospermum parkii fruit fat and shea butter common 3g (Butyrospermum parkii fruit fat and shea butter
Mass ratio is 1：1), Sodium Polyacrylate 0.1g and water 84.6g；
(2) Sodium Hyaluronate, Sodium Polyacrylate are well mixed with glycerine；
(3) trehalose is mixed with water, dissolves trehalose, obtain aqueous trehalose solution；
(4) mixture for preparing step (2) is added in aqueous trehalose solution, is heated to 85 DEG C, add shea butter and
Butyrospermum parkii fruit fat, stir 20 minutes；
(5) 35 DEG C are cooled to, is produced.
Compare 9 groups
(1) take：(mass ratio of middle-molecular-weihydroxyethyl Sodium Hyaluronate and small-molecular-weight Sodium Hyaluronate is 0.3g Sodium Hyaluronates
2:7, the molecular weight of middle-molecular-weihydroxyethyl Sodium Hyaluronate is 200000-300000, and the molecular weight of small-molecular-weight Sodium Hyaluronate is
6000-7000), 2g trehaloses, 10g glycerine, Butyrospermum parkii fruit fat and shea butter common 3g (Butyrospermum parkii fruit fat and shea butter
Mass ratio is 1：1), Sodium Polyacrylate 0.1g and water 84.6g
(2) Sodium Hyaluronate, Sodium Polyacrylate are well mixed with glycerine；
(3) trehalose is mixed with water, dissolves trehalose, obtain aqueous trehalose solution；
(4) mixture for preparing step (2) is added in aqueous trehalose solution, is heated to 85 DEG C, add shea butter and
Butyrospermum parkii fruit fat, stir 20 minutes；
(5) 35 DEG C are cooled to, is produced.
Embodiment 9
Skin permeation test in vitro
The Kunming mouse that quality is 18-22g is taken, the sodium sulfide solution for being 0.08g/mL with mass concentration sloughs belly
And back hair, take off neck and put to death, cut skin of abdomen respectively, remove fat and hypodermis on skin, it is anti-with physiological saline
Multiple repeatedly to rinse, filter paper blots surface moisture, and with the repeated multiple times flushing of physiological saline, filter paper blots surface moisture, is placed in physiology
In salt solution, 4 DEG C of refrigerators save backup.
Water is added in Transdermal Absorption test instrument thermostat, setting water temperature in thermostat, as (37 ± 0.1) DEG C, setting connects
The magnetic stirring speed of receives pond rotor is 40r/min, and the skin of mouse is fixed on to confession medicine pond and the reception tank of diffusion with clip
Between, stratum corneum side is upward, and skin corium downwards, drains bubble.
0.5mL experiment products (facial mask liquid and comparison liquid prepared by each embodiment) are taken to drop on mouse skin, area is about
1cm2, respectively at 1h, 2h, 4h, 6h, the liquid 1ml in reception tank is taken, and supplied with purified water into reception tank.
According to《Chinese Pharmacopoeia (the 4th)》The method of (2015 editions) is measured with HPLC to the content of trehalose.Calculate
Accumulative transdermal absorption factor.
This experiment has following experimental group：5 groups of embodiment, 6 groups of embodiment, 7 groups of embodiment, 8 groups of embodiment, control 1 group, it is right
According to 2 groups, control 3 groups, control 4 groups, control 5 groups, control 6 groups, control 7 groups, control 8 groups, control 9 groups.
Table 1, skin permeation test in vitro trehalose transmitance
| 1h | 2h | 4h | 6h | |
| Compare 1 group | 1.25% | 8.75% | 15.39% | 21.42% |
| Compare 2 groups | 1.36% | 17.64% | 28.68% | 40.38% |
| Compare 3 groups | 1.26% | 17.39% | 27.46% | 40.29% |
| Compare 4 groups | 1.93% | 17.84% | 27.91% | 41.09% |
| Compare 5 groups | 1.42% | 17.39% | 27.13% | 41.62% |
| Compare 6 groups | 1.39% | 17.46% | 27.39% | 41.71% |
| Compare 7 groups | 1.72% | 17.69% | 26.39% | 41.21% |
| Compare 8 groups | 1.38% | 17.38% | 26.84% | 41.48% |
| Compare 9 groups | 1.58% | 17.01% | 26.34% | 41.09% |
| 5 groups of embodiment | 7.26% | 21.27% | 39.16% | 52.48% |
| 6 groups of embodiment | 6.38% | 21.39% | 39.49% | 53.41% |
| 7 groups of embodiment | 8.71% | 22.04% | 40.16% | 54.17% |
| 8 groups of embodiment | 7.39% | 21.18% | 39.52% | 52.80% |
As can be seen from the above table, the composition of sebum film reparation of the invention, the preferable percutaneous absorbtion of energy, and the time is longer
Effect is better, add up transit dose it is higher, though and compareing 1-9 groups has the transdermal absorption of hyaluronic acid, from the saturating of any time period
Composition transmitance from the point of view of skin absorptivity without the present invention is high.
Embodiment 10
Skin moisture-keeping degree is measured using CK skinanalysis apparatus.
The people of volunteer 260 is selected, 13 groups is randomly divided into, every group of 20 people, cleans arm, dry, measure the basis of now skin
Value, experiment product (facial mask liquid and comparison liquid prepared by each embodiment) 0.05mL is taken uniformly to be applied to 1cm2Skin on, measurement 0h,
1h, 2h, 4h skin moisture-keeping.
Table 2, moistening effect result of the test
*Compared with 1 group of control, P ＜ 0.01
△ is with compareing 2 groups of ratios, P ＜ 0.05
1 group of control instant moistening effect after smearing is slightly good it can be seen from the present invention, and control 4-9 groups are from different points
The Sodium Hyaluronate of son amount can also reach good moistening effect, but embodiment 5-8 groups are an advantage over compareing from data
4-9 groups.
Embodiment 11
The clinical verification of the present invention is chosen at the beautifying medical mechanism people such as hospital and changes skin, micro- whole through facial laser, tartaric acid
The damaged skin caused by reason such as skin and sensitive, dermatitis after the invasive surgeries such as shape.In 260 sufferers of clinic
In, women 212, male 48, the age is 18-60 year.13 groups are randomly divided into, every group of 20 people.
This experiment has following experimental group：5 groups of embodiment；6 groups of embodiment；7 groups of embodiment；8 groups of embodiment；Compare 1 group；It is right
According to 2 groups；Compare 3 groups；Compare 4 groups；Compare 5 groups；Compare 6 groups；Compare 7 groups；Compare 8 groups；Compare 9 groups.
Application method：(1) based process：Clean cutaneous lesion.(2) product is used, is uniformly applied to cutaneous lesion, it is very thin
One layer, three times a day, dosage can be increased or decreased according to patient's actual conditions.20 days are 1 course for the treatment of.
Health giving quality index：Carried out with reference to the sensitive dermatitis standard of face[1,2]Symptom score:Itch, erythema, oedema, ooze out, do
Dry furfur, shouting pain, pigmentation press respectively without, it is light, in, restatement be 0-3 points.
Note：[1] clinical research [D] the Shandong Traditional Chinese Medicine University of beautiful antipruritic skin gels treatment facial dermatitis is opened, 2012.
[2] Liu Dongmei, Shen Weilu, Wang Kun, faces clinical treatment [J] the China traditional Chinese and western medicine sensitive through changing skin and tender skin postoperative skin is waited
With reference to skin cypridology magazine, 2012,11 (6):365-367.
According to pretherapy and post-treatment symptom, somatic feature score, reference《New Chinese medicine guideline of clinical investigations》, enter by following standard
Row therapeutic evaluation：
Recovery from illness:Symptom, somatic feature score reduce >=95%.
It is effective:Ache symptom, somatic feature score reduction >=70%,<95%.
Effectively:Symptom, somatic feature score reduce >=30%,<70%.
It is invalid:Symptom, sign are reduced less than 30%.
Recovery from illness+effective+effective number of cases calculates total effective rate.
Calculation formula is：[being integrated before (being integrated before treatment after integration-treatment)/treatment] × 100%.
Safety evaluatio：
In normal conditions of use, by the clinical practice of subject, the generation of adverse events is determined whether, and according to not
The degree of good event, and vital sign check for exception, and Product Safety is evaluated.
I levels：Safety, without any adverse events, vital sign checks without exception.
II grade：Compare safety, there is slight adverse events, be not required to do any processing can continual cure, vital sign checks nothing
It is abnormal.
III grade：There is safety issue, there are moderate adverse events, can continual cure or vital sign inspection after processing
Mile abnormality is looked into.
IV grade：Because serious adverse events stop to test, or vital sign checks obvious exception.
The experimental result of table 3
| Use medicine | Case load | Recovery from illness | It is effective | Effectively | It is invalid | It is efficient | Safety evaluatio |
| Compare 1 group | 20 | 3 | 5 | 6 | 6 | 35.00% | II grade |
| Compare 2 groups | 20 | 2 | 3 | 5 | 10 | 50.00% | II grade |
| Compare 3 groups | 20 | 2 | 3 | 4 | 11 | 45.00% | II grade |
| Compare 4 groups | 20 | 4 | 3 | 5 | 8 | 60.00% | II grade |
| Compare 5 groups | 20 | 6 | 4 | 3 | 7 | 65.00% | I levels |
| Compare 6 groups | 20 | 7 | 3 | 3 | 7 | 65.00% | I levels |
| Compare 7 groups | 20 | 5 | 4 | 6 | 7 | 65.00% | I levels |
| Compare 8 groups | 20 | 6 | 4 | 4 | 6 | 70.00% | I levels |
| Compare 9 groups | 20 | 6 | 5 | 3 | 6 | 70.00% | I levels |
| 5 groups of embodiment | 20 | 16 | 2 | 0 | 2 | 90.00% | I levels |
| 6 groups of embodiment | 20 | 16 | 1 | 1 | 2 | 90.00% | I levels |
| 7 groups of embodiment | 20 | 17 | 0 | 2 | 1 | 95.00% | I levels |
| 8 groups of embodiment | 20 | 16 | 1 | 1 | 2 | 90.00% | I levels |
The product effective percentage of the present invention achieves certain treatment more than 90.00% it can be seen from above-mentioned clinical test
Effect, wherein the using effect of embodiment 5-8 groups is better than control group effect, and (the optimal trehalose and hyaluronic acid of embodiment 7
The ratio of sodium) effect is best, illustrate the sebum film remediation composition of the present invention for people through facial laser, tartaric acid change skin,
The damaged skins caused by reason such as skin and sensitive, dermatitis after the invasive surgeries such as micro-shaping have good effect.
Safety evaluatio result：Adverse events do not occur for embodiment 5-8 groups, control 5-9 groups, and vital sign inspection is no different
Often, compareing 1 group has the red and swollen aggravation of 3 patients' appearance or face punctation occur, is taken a turn for the better after drug withdrawal；Compareing 2 groups has 1 patient
Occur drying furfur symptom, taken a turn for the better after processing；Compareing 3 groups has 2 patients facial red heat occur, pain, is taken a turn for the better after processing；
Compareing 4 groups has 1 patient facial swelling occur, is taken a turn for the better after drug withdrawal.
Above example only expresses the embodiment of the present invention, and its description is more specific and detailed, but can not
Therefore it is interpreted as the limitation to the scope of the claims of the present invention.It should be pointed out that for the person of ordinary skill of the art,
Without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to the protection model of the present invention
Enclose.
Claims (2)
1. sebum film maintenance composition, it is characterized in that being made up by mass percentage of following raw materials：Sodium Hyaluronate 0.1%-
1%, trehalose 0.2%-4%, glycerine 2%-15%, at least one of shea butter and Butyrospermum parkii fruit fat 1%-10%,
Sodium Polyacrylate 0.1%-0.5% and water 69.5%-96.6%；The Sodium Hyaluronate is 1 by mass ratio:(2~5):(5~
30) molecular weight ranges 1000000~2000000 macromolecule Sodium Hyaluronate, molecular weight ranges 100000~
400000 middle numerator sodium hyaluronate and molecular weight ranges forms in 5000~10000 micromolecule hyaluronic acid sodium.
2. the gel of the sebum film maintenance composition containing claim 1, it is characterized in that being made of following methods：
(1) Sodium Hyaluronate, Sodium Polyacrylate are well mixed with glycerine；
(2) trehalose is mixed with water, dissolves trehalose, obtain aqueous trehalose solution；
(3) mixture for preparing step (1) is added in aqueous trehalose solution, is heated to 80-90 DEG C, adds shea butter and ox
At least one of oily fruit tree fruit fat, stir 10-30 minutes；
(4) 30-40 DEG C is cooled to, is produced.
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| CN106389139A (en) * | 2016-11-22 | 2017-02-15 | 河南工业大学 | Acne-removing, mark-eliminating and skin-protecting multifunctional preparation and preparation method thereof |
| CN107412255A (en) * | 2017-08-11 | 2017-12-01 | 天津嘉氏堂科技有限公司 | Skin barrier remediation composition and preparation |
| CN107375032B (en) * | 2017-08-11 | 2021-02-19 | 天津嘉氏堂科技有限公司 | Composition for repairing skin barrier and preparation method thereof |
| CN107375012A (en) * | 2017-08-11 | 2017-11-24 | 天津嘉氏堂科技有限公司 | A kind of skin barrier remediation composition and preparation |
| CN114732844B (en) * | 2021-11-09 | 2023-05-16 | 西安润玉医疗科技有限公司 | Bionic membrane composition capable of immediately relaxing and preparing method thereof |
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| CN1679470A (en) * | 2005-01-12 | 2005-10-12 | 凌沛学 | Composition containing trehalose and transparent acid for cosmetics and preparation thereof |
| CN104306262A (en) * | 2014-10-18 | 2015-01-28 | 卢鹏 | Beauty mask |
| CN104587518A (en) * | 2015-02-06 | 2015-05-06 | 南京天纵易康生物科技有限公司 | Hyaluronic acid dressing and preparation method thereof |
| CN105012220A (en) * | 2014-04-21 | 2015-11-04 | 陈见芬 | Lotion for treating hormonous dermatitis |
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|---|---|---|---|---|
| CN1679470A (en) * | 2005-01-12 | 2005-10-12 | 凌沛学 | Composition containing trehalose and transparent acid for cosmetics and preparation thereof |
| CN105012220A (en) * | 2014-04-21 | 2015-11-04 | 陈见芬 | Lotion for treating hormonous dermatitis |
| CN104306262A (en) * | 2014-10-18 | 2015-01-28 | 卢鹏 | Beauty mask |
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