CN106580836B - A kind of oral care composition and its application containing plant factor - Google Patents
A kind of oral care composition and its application containing plant factor Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
- A61K36/575—Magnolia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/82—Theaceae (Tea family), e.g. camellia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/886—Aloeaceae (Aloe family), e.g. aloe vera
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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Abstract
The present invention discloses a kind of oral care composition containing plant factor and its application, the oral care composition according to parts by weight, is made of 0.2~2 part of grape fruit extract, 0.1~1 part of Magnolia cortex P.E, 0.1~1 part of aloe vera extract, 0.05~0.5 part of green-tea extract, 0.05~0.5 part of Paeonol and 0.05~1 part of Cortex Ilicis Rotundae extract.Oral care composition of the invention is not only able to inhibit or kill oral cavity germ, to effectively prevent the generation of saprodontia and periodontitis, also have simultaneously and reduces plaque, inhibits gingivitis, fresh breath, anti-inflammatory analgetic and other effects, and natural safety, being used to prepare oral care product helps to improve oral healthy condition.
Description
Technical field
The present invention relates to the application of oral care techniques field more particularly to plant extracts in oral care implement,
More particularly to a kind of oral care composition containing plant factor and its application.
Background technique
Currently, the kind of toothpaste is varied with the continuous development of dental care products, via single clear
The toothpaste of clean effect, developing into various has effects that different function toothpaste.It can in recent years, with toothpaste safety problem
Appearance, people start simultaneously on the basis of pursuing toothpaste efficiency and pursue pure natural, the harmless raw material of toothpaste of green.Medium-height grass
Medicine meets Chinese Consumer's culture and health tradition, and because having significant effect, the drug resistance of also avoidable bacterium, and depth is by state
Interior consumer's likes.
Since natural plant active component has good therapeutic effect, and natural environmental-protective, Small side effects, meets people and chase after
The consumption concept of nature and health is sought, only needs the plant extracts of lower content to can reach required effect, and source in product
Naturally, safety.Therefore, application of the natural plant extracts in oral care implement is able to fast development.
Ingredient used in existing plant toothpaste includes Radix Notoginseng, Radix zanthoxyli, the coptis, Yunnan Baiyao, Bai Pidong on the market
Blueness, aloe, green tea, ginkgo etc., these active components of plants all have heat-clearing solution fire, anti-inflammation detumescence, removing toxic substances and other effects substantially, non-
Often it is suitable for the dental products of gingiva care.Plant extracts toothpaste, which has, to be inhibited harmful bacteria in oral cavity, fresh breath, breathes out
The effects of protecting gum, prevention and treatment mouth disease, such as existing tooth paste product can stopping blooding, prevention and treatment hemodia on the market.
However, although the toothpaste of these plant components has different purposes and effect, but effect and performance are relatively simple, for common
Oral problem such as gingivitis, periodontitis, saprodontia etc., the effects of tending not to while effectively playing anti-inflammatory, antibacterial, analgesic, stop blooding.
In addition, the ecosystem that oral cavity is complicated as one, microorganism therebetween is varied, becomes multiple oral disease
Initiation factor.In order to efficiently control the pathogenic effects of pathogenic microorganism, various chemical classes bacteriostatic agents such as chlorohexidene, western pyrrole chlorine
Ammonium etc. is applied in oral care implement.Although they have certain effect, have the shortcomings that it is different degrees of, as bitter,
Stimulate mucous membrane, action time short etc., and be used for a long time and easily oral cavity flora caused to be lacked of proper care.Therefore, there is an urgent need to find one kind
Sterilization, efficient, safety, the oral active ingredients that can be used for a long time.
In conclusion research and development efficient sterilizing, and the oral cavity microflora ecological balance will not be destroyed, it can be used for a long time, and
Oral care implement with multi-functional, plurality kinds of health care and therapeutic effect is both able to satisfy the majority of consumers to the need of oral health
It wants, and has a vast market space.
Summary of the invention
It can effectively inhibit and kill oral cavity to cause a disease in view of the above-mentioned deficiencies in the prior art, it is an object of the present invention to provide one kind
Bacterium, while plaque can be effectively reduced again, inhibit gingivitis, and safely and effectively, the oral microorganism ecological balance will not be caused
The oral care composition containing plant factor.
It is another object of the present invention to provide above-mentioned oral care compositions to prepare answering in oral care product
With.
Above-mentioned purpose of the invention is achieved by following scheme:
A kind of oral care composition containing plant factor, the oral care composition are by each group of following parts by weight
It is grouped as:
Above-mentioned formula is preferably grouped as by each group of following parts by weight:
Main component in grape fruit extract is aurantiin, and above-mentioned grape fruit extract is extracted using commercially available grape fruit
The present invention can be achieved in object；Grape fruit extract of the invention is preferably mentioned using the grape fruit of commercially available naringin content >=98%
Take object.
Active constituent in Magnolia cortex P.E is Magnolol and Honokiol, and above-mentioned Magnolia cortex P.E uses commercially available Cortex Magnoliae Officinalis
The present invention can be achieved in extract；Magnolia cortex P.E of the invention preferably use commercially available (Magnolol and Honokiol) content >=
95% Magnolia cortex P.E.
The present invention can be achieved using commercially available aloe vera extract in above-mentioned aloe vera extract；Of the invention
Aloe vera extract preferably uses the aloe vera dry jelly powder of commercially available 200:1.
The present invention can be achieved using commercially available green-tea extract in above-mentioned green-tea extract；Green-tea extract of the invention is excellent
Choosing uses the green-tea extract of commercially available polyphenol content >=95%.
Above-mentioned Paeonol is a kind of substance that extract comes out from the dry root skin of ranunculaceae peony, chemical name
For 2 '--4 '-methoxyacetophenones of hydroxyl；Paeonol of the invention uses commercial goods.
Iron holly bark is the dry bark or root skin of holly plant ilexrotunda, and above-mentioned Cortex Ilicis Rotundae extract is rescued using commercially available
It must answer extract that the present invention can be achieved；Cortex Ilicis Rotundae extract of the invention preferably uses commercially available Syringin content for 2%
~5%, and the Cortex Ilicis Rotundae extract that pedunculoside content is 20%~30%.
Above-mentioned percentage is mass percent of the effective component in extract.
Through research, the inventor has found that Streptococcus mutans are main cariogenic bacterias, it is closely related with the generation of dental caries, and
Actinobacillus actinomycetem comitans and topical type aggressive periodontitis have substantial connection；Grape fruit extract has certain antibacterial activity,
It can achieve the effect that inhibition and killing Streptococcus mutans and actinobacillus actinomycetem comitans by destroying cell wall and cell membrane；In addition,
Grape fruit extract has higher bacteriostatic activity to staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa etc., pacifies to human body
The after birth that bacterium can be destroyed under full concentration has the function that antibacterial and sterilization.
Through research, the inventor has found that Magnolia cortex P.E is to cariogenic bacteria in plaque such as Streptococcus mutans, Actinomyces
Bacterium and has to the growth of Periodontal Pathogens in subgingival plaque such as porphyromonas gingivalis, Fusobacterium nucleatum and obvious inhibit to make
With, be plant origin natural anti-caries and anti-periodontal medicine.
Aloe extract, which has, sterilizes, is antibacterial, decomposes toxin, diminishes inflammation, and promotes wound healing effect, and have certain
Broad spectrum activity.Anthraquinone analog compound is the main part in aloe extract antimicrobial component, the Antibacterial Mechanism of anthraquinone analog compound
Mainly inhibit the oxidation and certain embodiments of thallus sugar and glycometabolism intermediate product, and in conjunction with DNA, interfere its template function,
Inhibit protein and nucleic acid synthesis.
The main component of green-tea extract is tea polyphenols, can inhibit the generation of cariogenicity streptococcus and pre- anti-caries, no
It only can inhibit streptococcic growth, and its adsorption capacity can be reduced, further suppress the activity of glycosyl transferase, in addition, also having
There is very strong deodorizing capability, breath freshening degree can be improved.
Paeonol has the pharmacological actions such as calmness is anti-inflammatory, antiallergic is antipyretic, is widely used in daily use chemicals and field of medicaments.
Cortex Ilicis Rotundae extract has certain antibacterial activity, can effectively inhibit the growth metabolism of plaque, reduces gingivitis
Generation.
Oral care composition containing plant factor of the invention can effectively inhibit and kill oral cavity pathogen, especially
Cause the bacteriums such as periodontitis, saprodontia, halitosis；Oral care composition of the invention can arrange in pairs or groups oral cavity well-known in the art
Upper acceptable carrier component is prepared into oral care product, such as toothpaste, mouthwash, tooth powder or oral spray.
Oral care composition containing plant factor of the invention prepares oral care product in other carrier components of arranging in pairs or groups
When, the dosage of the oral care composition is the 0.5%~6% of oral care product total weight, preferably 1%~3%.
Using the oral care product of the oral care composition preparation of the invention containing plant factor, surveyed through third party
Examination, effective bacteriostasis rate is up to 99.99%.
Compared with prior art, the invention has the following beneficial effects:
1. oral care composition of the invention is using the Portugal that can obviously inhibit Streptococcus mutans, actinobacillus actinomycetem comitans
Grape shaddock extract is able to suppress the Cortex Magnoliae Officinalis extraction of porphyromonas gingivalis, Streptococcus mutans, Fusobacterium nucleatum, lactobacillus acidophilus
Object inhibits to cause periodontitis, cariogenic tooth, the oral cavity pathogen for generating implication, simultaneously under the premise of not influencing oral cavity beneficial bacterium
The ecological balance of oral microorganism is not caused；And oral care composition of the invention also compounds the Ku La with antiinflammation
Rope aloe extract, the green-tea extract of fresh breath, the Paeonol of desensitization and the iron holly bark for takeing good care of gums healthy mention
Object is taken, oral problem can be effectively improved comprehensively, safeguards oral health.
2. Paeonol and magnolol are carried out composite usage in toothpaste by oral care composition of the invention, the root bark of tree peony is utilized
The inhibition of the bacteria resistance function and magnolol of phenol or the function of killing cariogenic bacteria, the two fungistatic effect have complementation, and combining makes
With antimicrobial spectrum can be expanded, enhance antibacterial effect；
3. oral care composition of the invention using grape fruit extract, Magnolia cortex P.E as antibacterial or fungicide,
Two Plant Extracts are nontoxic, non-stimulated natural antiseptic agent, while not influencing the oral microorganism ecological balance, energy
It is enough effectively to inhibit or kill oral cavity pathogen；
4. tea polyphenols contained by the grape fruit extract and green-tea extract in oral care composition of the invention are combined
It uses, can obviously inhibit the acid producing ability of Streptococcus mutans, to have certain synergistic function on anticaries efficacy；
5. oral care composition of the invention is not only able to inhibit or kills oral cavity harmful bacteria, to effectively prevent saprodontia
And the generation of periodontitis, while also having and reducing plaque, inhibiting gingivitis, fresh breath, anti-inflammatory analgetic and other effects, facilitate
Improve oral healthy condition.
Specific embodiment
The present invention is further described through combined with specific embodiments below, but specific embodiment does not appoint the present invention
What is limited.
1 toothpaste of embodiment
The toothpaste of the present embodiment, formula are grouped as by each group of following weight percent:
The above-mentioned oral care composition containing plant factor is grouped as by each group of following parts by weight:
Above-mentioned grape fruit extract is the grape fruit extract that commercially available naringin content is 98%；Above-mentioned Magnolia cortex P.E
For the Magnolia cortex P.E of commercially available (Magnolol and Honokiol) content 95%；Above-mentioned aloe vera extract is commercially available
The aloe vera dry jelly powder of 200:1；Above-mentioned green-tea extract is the green-tea extract of commercially available polyphenol content 98%；
Above-mentioned Cortex Ilicis Rotundae extract be commercially available Syringin content be 5%, the Cortex Ilicis Rotundae extract that pedunculoside content is 25%.
2 mouthwash of embodiment
The mouthwash of the present embodiment, formula are grouped as by each group of following weight percent:
The above-mentioned oral care composition containing plant factor is grouped as by each group of following parts by weight:
Above-mentioned grape fruit extract is the grape fruit extract that commercially available naringin content is 98%；Above-mentioned Magnolia cortex P.E
For the Magnolia cortex P.E of commercially available (Magnolol and Honokiol) content 98%；Above-mentioned aloe vera extract is commercially available
The aloe vera dry jelly powder of 200:1；Above-mentioned green-tea extract is the green-tea extract of commercially available polyphenol content 98%；
Above-mentioned Cortex Ilicis Rotundae extract be commercially available Syringin content be 4%, the Cortex Ilicis Rotundae extract that pedunculoside content is 30%.
3 bacteriostatic experiment of embodiment
The present embodiment uses the oral care composition containing plant factor of embodiment 1, carries out bacteriostatic experiment to it, specifically
Shown in steps are as follows:
Using dehydrated alcohol as solvent, the oral care composition containing plant factor of embodiment 1 is configured to quality percentage
The ethanol solution that specific concentration is 1% tests it to cariogenic bacteria such as porphyromonas gingivalis, Streptococcus mutans, tool core shuttle bar
The minimal inhibitory concentration (MIC) of bacterium and lactobacillus acidophilus, to the minimal inhibitory concentration of the relevant actinobacillus actinomycetem comitans of periodontitis,
And the minimal inhibitory concentration to other oral cavity pathogens, it is shown that test result is as follows:
Oral care composition of the present invention containing plant factor to the minimal inhibitory concentration (ppm) of porphyromonas gingivalis <
9.76；To the minimal inhibitory concentration (ppm) < 9.76 of Streptococcus mutans；To the minimal inhibitory concentration (ppm) of Fusobacterium nucleatum <
9.76；To the minimal inhibitory concentration (ppm) < 9.76 of lactobacillus acidophilus；To the minimal inhibitory concentration (ppm) of actinobacillus actinomycetem comitans
<9.76。
Oral care composition of the present invention containing plant factor to the minimal inhibitory concentration (ppm) of staphylococcus aureus <
48.80；To the minimal inhibitory concentration (ppm) < 162.10 of Escherichia coli；To the minimal inhibitory concentration (ppm) of bacillus subtilis <
92.50；To the minimal inhibitory concentration (ppm) < 390.53 of Pseudomonas aeruginosa.
It can be seen that the oral care composition of the invention containing plant factor to cariogenic bacteria from above-mentioned test result
And other pathogenic bacteria all have good fungistatic effect.
4 anti-plaque of case study on implementation and gingivitis effect
It is checked by oral soft tissue to subject and sclerous tissues, oulitis and bacterial plaque inspection, screens suitable subject
60 people are randomly divided into experimental group and control group, every group of 30 people.
Experimental group uses the toothpaste of embodiment 1；The formulation of tooth-paste that control group uses is in addition to containing plant without containing the present invention
The oral care composition of the factor, remaining is all identical with the formulation of tooth-paste of embodiment 1.
To the respective toothpaste of subject's unified payment and soft toothbrush, it is desirable that subject brushes teeth 2 times on the 1st by regulation
(early, evening), each time 1min.It is required that any other dental care product is not used in experimentation, such as other kinds of tooth
Cream, toothbrush, gargle, dental floss etc..To diet and smoke with no restrictions.The toothpaste and toothbrush of supplement experiment at 6 weeks.Using tooth
At cream toothbrush 6 weeks and 12 weeks, subject's plaque and gingivitis situation are assessed according to the program of baseline inspection.
Index of gingivitis and inspection method (Loe-Silness):
Gingivitis and bleeding gums situation are measured using index of gingivitis test method, are surveyed before measuring plaque index
Measure gum situation.Index of gingivitis method of counting and standard are as follows:
0=gum edge and gum nipple healthy appearance, light not bleeding after visiting gingival sulcus；
1=gum edge and gum nipple healthy appearance, light bleeding after visiting gingival sulcus；
2=gum examines rear bleeding (petechial hemorrhage) because of inflammation color change, no swelling or oedema, spy；
3=gum color change is slight, oedema, bleeding after probe (bleeding is extended along gum edge)；
4=gum color change, hence it is evident that oedema, bleeding after probe (gum edge is overflowed in bleeding)；
5=gum color change, hence it is evident that oedema has ulcer sometimes, bleeding or has automatic bleeding after probe.
Check each facies buccalis dentis and lingual surface, a tooth maximum numeration is 10.The mean of bleeding gums index refers to all teeth
The summation (each 2 face of tooth) of counter value is divided by total measuring surface number (tooth of measurement multiplies 2) institute's value.
Plaque index and inspection method: supragingival plaque is evaluated using Quigley-Hein improvement Turesky plaque index, is made
With after staining reagent according to following standard recording:
0=is without bacterial plaque；
There is the bacterial plaque being dispersed in 1=tooth neck edge；
The visible continuous thin bacterial plaque band (reaching 1mm wide) of 2=tooth neck edge；
3=neck portion bacterial plaque band is greater than 1mm but is less than the 1/3 of facing；
The 1/3-2/3 of 4=bacterial plaque covering facing；
5=bacterial plaque covers 2/3 or more facing.
Check the buccal surface and lingual surface of each tooth (each tooth maximum numeration is 10).The mean of each subject's plaque index
The sum of numeration obtained by the whole tooth detections of individual (each tooth 2 records) is obtained divided by total measurement number (teeth number is multiplied by 2)
It arrives.
Table 1 completes the baseline inspection result of tested crowd
* mean ± standard deviation
Test result is shown in Table 2.
The test of table 2 front and back subject's gingivitis indices and plaque index situation of change
From table 2 it can be seen that oral care composition of the present invention containing plant factor can effectively reduce plaque, inhibit
Gingivitis.
According to the disclosure and teachings of the above specification, those skilled in the art in the invention can also be to above-mentioned embodiment party
Formula is changed and is modified.Therefore, the invention is not limited to the specific embodiments disclosed and described above, to of the invention
Some modifications and changes should also be as falling into the scope of the claims of the present invention.In addition, although being used in this specification
Some specific terms, these terms are merely for convenience of description, does not limit the present invention in any way.
Claims (5)
1. a kind of oral care composition containing plant factor, it is characterised in that the oral care composition is by following parts by weight
Several each groups are grouped as:
The grape fruit extract is the grape fruit extract of naringin content >=98%；
The Magnolia cortex P.E is the Magnolia cortex P.E of Magnolol and Honokiol content >=95%；
The aloe vera extract is the aloe vera dry jelly powder of 200:1；
The green-tea extract is the green-tea extract of polyphenol content >=95%；
The Syringin content of the Cortex Ilicis Rotundae extract is 2%~5%, and pedunculoside content is 20%~30%.
2. according to claim 1 containing the oral care composition of plant factor, it is characterised in that the oral care composition
It is to be grouped as by each group of following parts by weight:
3. the oral care composition as claimed in claim 1 or 2 containing plant factor is preparing the application in oral care product.
4. applying according to claim 3, it is characterised in that the dosage of the oral care composition is oral care product
The 0.5%~6% of total weight.
5. applying according to claim 4, it is characterised in that the dosage of the oral care composition is oral care product
The 1%~3% of total weight.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| IT202100000359A1 (en) * | 2021-01-11 | 2022-07-11 | Mario Paolo Donnaloja | ORAL CARE PRODUCT AND METHOD FOR ITS PREPARATION |
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| CN110327232B (en) * | 2019-08-12 | 2021-02-26 | 白银香生物科技有限公司 | Ilicis cortex mouthwash |
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| CN106580836A (en) | 2017-04-26 |
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