CN106562921A - 一种含有中药活性物质和茶树精油液体口腔用组合物 - Google Patents
一种含有中药活性物质和茶树精油液体口腔用组合物 Download PDFInfo
- Publication number
- CN106562921A CN106562921A CN201610943361.9A CN201610943361A CN106562921A CN 106562921 A CN106562921 A CN 106562921A CN 201610943361 A CN201610943361 A CN 201610943361A CN 106562921 A CN106562921 A CN 106562921A
- Authority
- CN
- China
- Prior art keywords
- extract
- tea tree
- oral composition
- oil
- liquid oral
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 235000009024 Ceanothus sanguineus Nutrition 0.000 title claims abstract description 76
- 240000003553 Leptospermum scoparium Species 0.000 title claims abstract description 76
- 235000015459 Lycium barbarum Nutrition 0.000 title claims abstract description 76
- 239000000341 volatile oil Substances 0.000 title claims abstract description 70
- 239000000203 mixture Substances 0.000 title claims abstract description 64
- 239000007788 liquid Substances 0.000 title claims abstract description 58
- 239000013543 active substance Substances 0.000 title abstract description 5
- 239000000284 extract Substances 0.000 claims abstract description 186
- 239000000463 material Substances 0.000 claims abstract description 52
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 32
- 235000015763 Artemisia ludoviciana Nutrition 0.000 claims abstract description 22
- PXFBZOLANLWPMH-UHFFFAOYSA-N 16-Epiaffinine Natural products C1C(C2=CC=CC=C2N2)=C2C(=O)CC2C(=CC)CN(C)C1C2CO PXFBZOLANLWPMH-UHFFFAOYSA-N 0.000 claims abstract description 21
- 241000608847 Gnaphalium Species 0.000 claims abstract description 21
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims abstract description 16
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims abstract description 16
- 229940041616 menthol Drugs 0.000 claims abstract description 16
- 239000003814 drug Substances 0.000 claims abstract description 14
- 239000003755 preservative agent Substances 0.000 claims abstract description 11
- 230000002335 preservative effect Effects 0.000 claims abstract description 11
- 239000000654 additive Substances 0.000 claims abstract description 9
- 229940094952 green tea extract Drugs 0.000 claims abstract description 8
- 235000020688 green tea extract Nutrition 0.000 claims abstract description 8
- 239000000080 wetting agent Substances 0.000 claims abstract description 7
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 84
- XMGQYMWWDOXHJM-UHFFFAOYSA-N limonene Chemical compound CC(=C)C1CCC(C)=CC1 XMGQYMWWDOXHJM-UHFFFAOYSA-N 0.000 claims description 60
- 239000003390 Chinese drug Substances 0.000 claims description 40
- 150000001669 calcium Chemical class 0.000 claims description 32
- 238000002360 preparation method Methods 0.000 claims description 32
- 235000014220 Rhus chinensis Nutrition 0.000 claims description 30
- 240000003152 Rhus chinensis Species 0.000 claims description 30
- 229940087305 limonene Drugs 0.000 claims description 29
- 235000001510 limonene Nutrition 0.000 claims description 29
- 239000003921 oil Substances 0.000 claims description 29
- 235000019198 oils Nutrition 0.000 claims description 29
- 235000019501 Lemon oil Nutrition 0.000 claims description 28
- 239000010501 lemon oil Substances 0.000 claims description 28
- 238000000034 method Methods 0.000 claims description 27
- 244000047670 Viola x wittrockiana Species 0.000 claims description 25
- 235000004031 Viola x wittrockiana Nutrition 0.000 claims description 25
- 239000001509 sodium citrate Substances 0.000 claims description 24
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims description 24
- 235000005747 Carum carvi Nutrition 0.000 claims description 22
- 240000000467 Carum carvi Species 0.000 claims description 22
- 244000228451 Stevia rebaudiana Species 0.000 claims description 21
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims description 18
- 239000001110 calcium chloride Substances 0.000 claims description 18
- 229910001628 calcium chloride Inorganic materials 0.000 claims description 18
- 229940105902 mint extract Drugs 0.000 claims description 18
- 244000025254 Cannabis sativa Species 0.000 claims description 17
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims description 16
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 16
- 241000241413 Propolis Species 0.000 claims description 16
- 229940069949 propolis Drugs 0.000 claims description 16
- HELXLJCILKEWJH-NCGAPWICSA-N rebaudioside A Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O HELXLJCILKEWJH-NCGAPWICSA-N 0.000 claims description 16
- 235000017617 Lonicera japonica Nutrition 0.000 claims description 15
- 244000167230 Lonicera japonica Species 0.000 claims description 15
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 15
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 15
- 239000000811 xylitol Substances 0.000 claims description 15
- 235000010447 xylitol Nutrition 0.000 claims description 15
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 15
- 229960002675 xylitol Drugs 0.000 claims description 15
- 239000000706 filtrate Substances 0.000 claims description 14
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 10
- 239000000686 essence Substances 0.000 claims description 10
- 230000001954 sterilising effect Effects 0.000 claims description 10
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 9
- 239000003002 pH adjusting agent Substances 0.000 claims description 9
- 238000004659 sterilization and disinfection Methods 0.000 claims description 9
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 claims description 8
- FJKROLUGYXJWQN-UHFFFAOYSA-N 4-hydroxybenzoic acid Chemical class OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims description 7
- 230000000996 additive effect Effects 0.000 claims description 7
- XHXUANMFYXWVNG-ADEWGFFLSA-N (-)-Menthyl acetate Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1OC(C)=O XHXUANMFYXWVNG-ADEWGFFLSA-N 0.000 claims description 6
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims description 6
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 6
- RRAFCDWBNXTKKO-UHFFFAOYSA-N eugenol Chemical compound COC1=CC(CC=C)=CC=C1O RRAFCDWBNXTKKO-UHFFFAOYSA-N 0.000 claims description 6
- CDOSHBSSFJOMGT-UHFFFAOYSA-N linalool Chemical compound CC(C)=CCCC(C)(O)C=C CDOSHBSSFJOMGT-UHFFFAOYSA-N 0.000 claims description 6
- XNGIFLGASWRNHJ-UHFFFAOYSA-N phthalic acid Chemical compound OC(=O)C1=CC=CC=C1C(O)=O XNGIFLGASWRNHJ-UHFFFAOYSA-N 0.000 claims description 6
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 claims description 6
- BXOCHUWSGYYSFW-HVWOQQCMSA-N spilanthol Chemical compound C\C=C\C=C/CC\C=C\C(=O)NCC(C)C BXOCHUWSGYYSFW-HVWOQQCMSA-N 0.000 claims description 6
- MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 claims description 6
- 229920001661 Chitosan Polymers 0.000 claims description 5
- -1 diaminourea carbethoxy hydrochloride Chemical compound 0.000 claims description 5
- 238000012545 processing Methods 0.000 claims description 5
- 240000002943 Elettaria cardamomum Species 0.000 claims description 4
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 4
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 4
- 235000009421 Myristica fragrans Nutrition 0.000 claims description 4
- 235000011203 Origanum Nutrition 0.000 claims description 4
- 240000000783 Origanum majorana Species 0.000 claims description 4
- 235000007303 Thymus vulgaris Nutrition 0.000 claims description 4
- 240000002657 Thymus vulgaris Species 0.000 claims description 4
- 235000005300 cardamomo Nutrition 0.000 claims description 4
- 238000005253 cladding Methods 0.000 claims description 4
- 239000010642 eucalyptus oil Substances 0.000 claims description 4
- 229940044949 eucalyptus oil Drugs 0.000 claims description 4
- 239000001257 hydrogen Substances 0.000 claims description 4
- 229910052739 hydrogen Inorganic materials 0.000 claims description 4
- 239000001115 mace Substances 0.000 claims description 4
- 239000001683 mentha spicata herb oil Substances 0.000 claims description 4
- 239000010668 rosemary oil Substances 0.000 claims description 4
- 229940058206 rosemary oil Drugs 0.000 claims description 4
- 239000010670 sage oil Substances 0.000 claims description 4
- 239000011734 sodium Substances 0.000 claims description 4
- 229910052708 sodium Inorganic materials 0.000 claims description 4
- 235000019721 spearmint oil Nutrition 0.000 claims description 4
- 229960005137 succinic acid Drugs 0.000 claims description 4
- 239000001585 thymus vulgaris Substances 0.000 claims description 4
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims description 3
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 claims description 3
- 239000001490 (3R)-3,7-dimethylocta-1,6-dien-3-ol Substances 0.000 claims description 3
- 239000001605 (5-methyl-2-propan-2-ylcyclohexyl) acetate Substances 0.000 claims description 3
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 claims description 3
- CDOSHBSSFJOMGT-JTQLQIEISA-N (R)-linalool Natural products CC(C)=CCC[C@@](C)(O)C=C CDOSHBSSFJOMGT-JTQLQIEISA-N 0.000 claims description 3
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims description 3
- 150000000193 1,8-cineol derivatives Chemical class 0.000 claims description 3
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 claims description 3
- QFOHBWFCKVYLES-UHFFFAOYSA-N Butylparaben Chemical compound CCCCOC(=O)C1=CC=C(O)C=C1 QFOHBWFCKVYLES-UHFFFAOYSA-N 0.000 claims description 3
- NPBVQXIMTZKSBA-UHFFFAOYSA-N Chavibetol Natural products COC1=CC=C(CC=C)C=C1O NPBVQXIMTZKSBA-UHFFFAOYSA-N 0.000 claims description 3
- 241000723346 Cinnamomum camphora Species 0.000 claims description 3
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 3
- XHXUANMFYXWVNG-UHFFFAOYSA-N D-menthyl acetate Natural products CC(C)C1CCC(C)CC1OC(C)=O XHXUANMFYXWVNG-UHFFFAOYSA-N 0.000 claims description 3
- 239000005770 Eugenol Substances 0.000 claims description 3
- 240000001238 Gaultheria procumbens Species 0.000 claims description 3
- 235000007297 Gaultheria procumbens Nutrition 0.000 claims description 3
- 239000004471 Glycine Substances 0.000 claims description 3
- UVMRYBDEERADNV-UHFFFAOYSA-N Pseudoeugenol Natural products COC1=CC(C(C)=C)=CC=C1O UVMRYBDEERADNV-UHFFFAOYSA-N 0.000 claims description 3
- 239000005844 Thymol Substances 0.000 claims description 3
- BXOCHUWSGYYSFW-UHFFFAOYSA-N all-trans spilanthol Natural products CC=CC=CCCC=CC(=O)NCC(C)C BXOCHUWSGYYSFW-UHFFFAOYSA-N 0.000 claims description 3
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims description 3
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims description 3
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 claims description 3
- 229940116229 borneol Drugs 0.000 claims description 3
- 229930008380 camphor Natural products 0.000 claims description 3
- 229960000846 camphor Drugs 0.000 claims description 3
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 claims description 3
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 claims description 3
- 229940093476 ethylene glycol Drugs 0.000 claims description 3
- 229960002217 eugenol Drugs 0.000 claims description 3
- 239000001530 fumaric acid Substances 0.000 claims description 3
- 239000000832 lactitol Substances 0.000 claims description 3
- 235000010448 lactitol Nutrition 0.000 claims description 3
- VQHSOMBJVWLPSR-JVCRWLNRSA-N lactitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-JVCRWLNRSA-N 0.000 claims description 3
- 229960003451 lactitol Drugs 0.000 claims description 3
- 239000000171 lavandula angustifolia l. flower oil Substances 0.000 claims description 3
- 229930007744 linalool Natural products 0.000 claims description 3
- 239000001630 malic acid Substances 0.000 claims description 3
- 235000011090 malic acid Nutrition 0.000 claims description 3
- 239000000845 maltitol Substances 0.000 claims description 3
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 claims description 3
- 235000010449 maltitol Nutrition 0.000 claims description 3
- 229940035436 maltitol Drugs 0.000 claims description 3
- 150000002729 menthone derivatives Chemical class 0.000 claims description 3
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 claims description 3
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 claims description 3
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 claims description 3
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims description 3
- 239000004302 potassium sorbate Substances 0.000 claims description 3
- 235000010241 potassium sorbate Nutrition 0.000 claims description 3
- 229940069338 potassium sorbate Drugs 0.000 claims description 3
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 claims description 3
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 claims description 3
- 229960003415 propylparaben Drugs 0.000 claims description 3
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims description 3
- 239000004299 sodium benzoate Substances 0.000 claims description 3
- 235000010234 sodium benzoate Nutrition 0.000 claims description 3
- 229960000790 thymol Drugs 0.000 claims description 3
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 3
- NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 claims 2
- WTEVQBCEXWBHNA-UHFFFAOYSA-N Citral Natural products CC(C)=CCCC(C)=CC=O WTEVQBCEXWBHNA-UHFFFAOYSA-N 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 229940043350 citral Drugs 0.000 claims 1
- SEGLCEQVOFDUPX-UHFFFAOYSA-N di-(2-ethylhexyl)phosphoric acid Chemical compound CCCCC(CC)COP(O)(=O)OCC(CC)CCCC SEGLCEQVOFDUPX-UHFFFAOYSA-N 0.000 claims 1
- 239000004403 ethyl p-hydroxybenzoate Substances 0.000 claims 1
- 235000010228 ethyl p-hydroxybenzoate Nutrition 0.000 claims 1
- WTEVQBCEXWBHNA-JXMROGBWSA-N geranial Chemical compound CC(C)=CCC\C(C)=C\C=O WTEVQBCEXWBHNA-JXMROGBWSA-N 0.000 claims 1
- 239000003906 humectant Substances 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- 241000205585 Aquilegia canadensis Species 0.000 abstract 1
- 235000003805 Musa ABB Group Nutrition 0.000 abstract 1
- 240000008790 Musa x paradisiaca Species 0.000 abstract 1
- 235000015266 Plantago major Nutrition 0.000 abstract 1
- 239000008394 flocculating agent Substances 0.000 abstract 1
- 229940099576 lamium album extract Drugs 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 73
- 244000269722 Thea sinensis Species 0.000 description 28
- 235000013616 tea Nutrition 0.000 description 25
- 241001570521 Lonicera periclymenum Species 0.000 description 19
- 230000008859 change Effects 0.000 description 15
- 210000000214 mouth Anatomy 0.000 description 15
- 230000000694 effects Effects 0.000 description 14
- 235000009569 green tea Nutrition 0.000 description 14
- 239000000796 flavoring agent Substances 0.000 description 12
- 235000019634 flavors Nutrition 0.000 description 12
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 11
- 239000011575 calcium Substances 0.000 description 11
- 229910052791 calcium Inorganic materials 0.000 description 11
- 235000009508 confectionery Nutrition 0.000 description 11
- 239000012467 final product Substances 0.000 description 11
- 238000010438 heat treatment Methods 0.000 description 11
- 206010011224 Cough Diseases 0.000 description 10
- 150000001804 chlorine Chemical class 0.000 description 9
- 239000002324 mouth wash Substances 0.000 description 9
- 229940051866 mouthwash Drugs 0.000 description 9
- 239000002253 acid Substances 0.000 description 8
- 238000012360 testing method Methods 0.000 description 8
- 244000131522 Citrus pyriformis Species 0.000 description 7
- 244000246386 Mentha pulegium Species 0.000 description 7
- 235000016257 Mentha pulegium Nutrition 0.000 description 7
- 235000004357 Mentha x piperita Nutrition 0.000 description 7
- 235000013305 food Nutrition 0.000 description 7
- 230000006870 function Effects 0.000 description 7
- 235000001050 hortel pimenta Nutrition 0.000 description 7
- 210000004072 lung Anatomy 0.000 description 7
- 239000003507 refrigerant Substances 0.000 description 7
- 235000005979 Citrus limon Nutrition 0.000 description 6
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 6
- 201000010099 disease Diseases 0.000 description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 6
- 238000009826 distribution Methods 0.000 description 6
- 238000000605 extraction Methods 0.000 description 6
- 210000002784 stomach Anatomy 0.000 description 6
- 241000894006 Bacteria Species 0.000 description 5
- 208000002193 Pain Diseases 0.000 description 5
- 235000006092 Stevia rebaudiana Nutrition 0.000 description 5
- 230000003110 anti-inflammatory effect Effects 0.000 description 5
- 230000000052 comparative effect Effects 0.000 description 5
- 239000011521 glass Substances 0.000 description 5
- 230000036407 pain Effects 0.000 description 5
- 150000008442 polyphenolic compounds Chemical class 0.000 description 5
- 235000013824 polyphenols Nutrition 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- 238000003756 stirring Methods 0.000 description 5
- 240000006891 Artemisia vulgaris Species 0.000 description 4
- YYEQHIXJBSSBJU-UHFFFAOYSA-L C(C=C)(=O)O.[Cl-].[Ca+2].[Cl-] Chemical compound C(C=C)(=O)O.[Cl-].[Ca+2].[Cl-] YYEQHIXJBSSBJU-UHFFFAOYSA-L 0.000 description 4
- 235000007516 Chrysanthemum Nutrition 0.000 description 4
- 206010012735 Diarrhoea Diseases 0.000 description 4
- 206010044565 Tremor Diseases 0.000 description 4
- 230000000844 anti-bacterial effect Effects 0.000 description 4
- 239000007864 aqueous solution Substances 0.000 description 4
- 235000013399 edible fruits Nutrition 0.000 description 4
- 239000003205 fragrance Substances 0.000 description 4
- 229930182478 glucoside Natural products 0.000 description 4
- 238000007654 immersion Methods 0.000 description 4
- 210000003734 kidney Anatomy 0.000 description 4
- 238000002386 leaching Methods 0.000 description 4
- 231100000614 poison Toxicity 0.000 description 4
- 229920000137 polyphosphoric acid Polymers 0.000 description 4
- 230000001737 promoting effect Effects 0.000 description 4
- 239000002994 raw material Substances 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 208000002874 Acne Vulgaris Diseases 0.000 description 3
- 206010007247 Carbuncle Diseases 0.000 description 3
- 244000189548 Chrysanthemum x morifolium Species 0.000 description 3
- 229920000742 Cotton Polymers 0.000 description 3
- UEDUENGHJMELGK-HYDKPPNVSA-N Stevioside Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UEDUENGHJMELGK-HYDKPPNVSA-N 0.000 description 3
- 206010000269 abscess Diseases 0.000 description 3
- 206010000496 acne Diseases 0.000 description 3
- 239000002260 anti-inflammatory agent Substances 0.000 description 3
- 230000001741 anti-phlogistic effect Effects 0.000 description 3
- 208000006673 asthma Diseases 0.000 description 3
- 230000003385 bacteriostatic effect Effects 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- 230000001408 fungistatic effect Effects 0.000 description 3
- 150000008131 glucosides Chemical class 0.000 description 3
- 150000004676 glycans Chemical class 0.000 description 3
- 210000003128 head Anatomy 0.000 description 3
- 239000002574 poison Substances 0.000 description 3
- 229920001282 polysaccharide Polymers 0.000 description 3
- 239000005017 polysaccharide Substances 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 230000035807 sensation Effects 0.000 description 3
- 235000019615 sensations Nutrition 0.000 description 3
- 229940013618 stevioside Drugs 0.000 description 3
- OHHNJQXIOPOJSC-UHFFFAOYSA-N stevioside Natural products CC1(CCCC2(C)C3(C)CCC4(CC3(CCC12C)CC4=C)OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(=O)OC7OC(CO)C(O)C(O)C7O OHHNJQXIOPOJSC-UHFFFAOYSA-N 0.000 description 3
- 235000019202 steviosides Nutrition 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 239000006228 supernatant Substances 0.000 description 3
- 239000003053 toxin Substances 0.000 description 3
- 231100000765 toxin Toxicity 0.000 description 3
- 229940090248 4-hydroxybenzoic acid Drugs 0.000 description 2
- 208000004998 Abdominal Pain Diseases 0.000 description 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 2
- 240000002319 Citrus sinensis Species 0.000 description 2
- 229920000832 Cutin Polymers 0.000 description 2
- 206010013935 Dysmenorrhoea Diseases 0.000 description 2
- WEEGYLXZBRQIMU-UHFFFAOYSA-N Eucalyptol Chemical compound C1CC2CCC1(C)OC2(C)C WEEGYLXZBRQIMU-UHFFFAOYSA-N 0.000 description 2
- OPUFDNZTKHPZHM-UHFFFAOYSA-N Euparin Chemical compound CC(=O)C1=C(O)C=C2OC(C(=C)C)=CC2=C1 OPUFDNZTKHPZHM-UHFFFAOYSA-N 0.000 description 2
- 208000032843 Hemorrhage Diseases 0.000 description 2
- 206010020772 Hypertension Diseases 0.000 description 2
- 208000001953 Hypotension Diseases 0.000 description 2
- 244000088413 Matthiola incana Species 0.000 description 2
- 235000011378 Matthiola incana Nutrition 0.000 description 2
- 240000001307 Myosotis scorpioides Species 0.000 description 2
- 206010030113 Oedema Diseases 0.000 description 2
- 240000007594 Oryza sativa Species 0.000 description 2
- 235000007164 Oryza sativa Nutrition 0.000 description 2
- 235000002770 Petroselinum crispum Nutrition 0.000 description 2
- 240000009164 Petroselinum crispum Species 0.000 description 2
- 241001499733 Plantago asiatica Species 0.000 description 2
- 235000003434 Sesamum indicum Nutrition 0.000 description 2
- 244000040738 Sesamum orientale Species 0.000 description 2
- 241000191967 Staphylococcus aureus Species 0.000 description 2
- 229930182558 Sterol Natural products 0.000 description 2
- 235000009108 Urtica dioica Nutrition 0.000 description 2
- 244000274883 Urtica dioica Species 0.000 description 2
- 150000001299 aldehydes Chemical class 0.000 description 2
- 239000003513 alkali Substances 0.000 description 2
- 229940024606 amino acid Drugs 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 230000000202 analgesic effect Effects 0.000 description 2
- 230000001093 anti-cancer Effects 0.000 description 2
- 230000001139 anti-pruritic effect Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 206010006451 bronchitis Diseases 0.000 description 2
- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 description 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 2
- 238000005119 centrifugation Methods 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 239000000460 chlorine Substances 0.000 description 2
- 229910052801 chlorine Inorganic materials 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 229960005233 cineole Drugs 0.000 description 2
- 235000015165 citric acid Nutrition 0.000 description 2
- 230000001276 controlling effect Effects 0.000 description 2
- RWGFKTVRMDUZSP-UHFFFAOYSA-N cumene Chemical compound CC(C)C1=CC=CC=C1 RWGFKTVRMDUZSP-UHFFFAOYSA-N 0.000 description 2
- 238000000502 dialysis Methods 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 208000001848 dysentery Diseases 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 208000001780 epistaxis Diseases 0.000 description 2
- 125000004494 ethyl ester group Chemical group 0.000 description 2
- BUMHLZPAQKNDBJ-JTQLQIEISA-N euparin Natural products CC=C[C@H]1Cc2cc(C(=O)C)c(O)cc2O1 BUMHLZPAQKNDBJ-JTQLQIEISA-N 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 238000005562 fading Methods 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 235000013373 food additive Nutrition 0.000 description 2
- 239000002778 food additive Substances 0.000 description 2
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 2
- 239000010931 gold Substances 0.000 description 2
- 229910052737 gold Inorganic materials 0.000 description 2
- IUJAMGNYPWYUPM-UHFFFAOYSA-N hentriacontane Chemical compound CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC IUJAMGNYPWYUPM-UHFFFAOYSA-N 0.000 description 2
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 2
- 208000021822 hypotensive Diseases 0.000 description 2
- 230000001077 hypotensive effect Effects 0.000 description 2
- VKOBVWXKNCXXDE-UHFFFAOYSA-N icosanoic acid Chemical compound CCCCCCCCCCCCCCCCCCCC(O)=O VKOBVWXKNCXXDE-UHFFFAOYSA-N 0.000 description 2
- 150000002576 ketones Chemical class 0.000 description 2
- 230000003902 lesion Effects 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 201000007227 lymph node tuberculosis Diseases 0.000 description 2
- 235000012054 meals Nutrition 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 239000002609 medium Substances 0.000 description 2
- 230000000813 microbial effect Effects 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 229910000403 monosodium phosphate Inorganic materials 0.000 description 2
- 235000019799 monosodium phosphate Nutrition 0.000 description 2
- 210000002200 mouth mucosa Anatomy 0.000 description 2
- 238000011056 performance test Methods 0.000 description 2
- 239000002304 perfume Substances 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 238000001556 precipitation Methods 0.000 description 2
- 238000010791 quenching Methods 0.000 description 2
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 2
- 238000005057 refrigeration Methods 0.000 description 2
- 235000009566 rice Nutrition 0.000 description 2
- 229930182490 saponin Natural products 0.000 description 2
- 150000007949 saponins Chemical class 0.000 description 2
- 235000017709 saponins Nutrition 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 210000000952 spleen Anatomy 0.000 description 2
- 235000003702 sterols Nutrition 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- 230000035922 thirst Effects 0.000 description 2
- 229940126680 traditional chinese medicines Drugs 0.000 description 2
- QAIPRVGONGVQAS-DUXPYHPUSA-N trans-caffeic acid Chemical compound OC(=O)\C=C\C1=CC=C(O)C(O)=C1 QAIPRVGONGVQAS-DUXPYHPUSA-N 0.000 description 2
- 235000014101 wine Nutrition 0.000 description 2
- PFTAWBLQPZVEMU-DZGCQCFKSA-N (+)-catechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-DZGCQCFKSA-N 0.000 description 1
- KZJWDPNRJALLNS-VPUBHVLGSA-N (-)-beta-Sitosterol Natural products O[C@@H]1CC=2[C@@](C)([C@@H]3[C@H]([C@H]4[C@@](C)([C@H]([C@H](CC[C@@H](C(C)C)CC)C)CC4)CC3)CC=2)CC1 KZJWDPNRJALLNS-VPUBHVLGSA-N 0.000 description 1
- CSVWWLUMXNHWSU-UHFFFAOYSA-N (22E)-(24xi)-24-ethyl-5alpha-cholest-22-en-3beta-ol Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(C)C=CC(CC)C(C)C)C1(C)CC2 CSVWWLUMXNHWSU-UHFFFAOYSA-N 0.000 description 1
- WCGUUGGRBIKTOS-GPOJBZKASA-N (3beta)-3-hydroxyurs-12-en-28-oic acid Chemical compound C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CC[C@@H](C)[C@H](C)[C@H]5C4=CC[C@@H]3[C@]21C WCGUUGGRBIKTOS-GPOJBZKASA-N 0.000 description 1
- ACEAELOMUCBPJP-UHFFFAOYSA-N (E)-3,4,5-trihydroxycinnamic acid Natural products OC(=O)C=CC1=CC(O)=C(O)C(O)=C1 ACEAELOMUCBPJP-UHFFFAOYSA-N 0.000 description 1
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 1
- KLEXDBGYSOIREE-UHFFFAOYSA-N 24xi-n-propylcholesterol Natural products C1C=C2CC(O)CCC2(C)C2C1C1CCC(C(C)CCC(CCC)C(C)C)C1(C)CC2 KLEXDBGYSOIREE-UHFFFAOYSA-N 0.000 description 1
- 206010000087 Abdominal pain upper Diseases 0.000 description 1
- 229930024421 Adenine Natural products 0.000 description 1
- GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 description 1
- 241000608330 Anacamptis Species 0.000 description 1
- YXEPEHFXXORWGP-BRAIEQGRSA-N Anisoxide Natural products C(=C/c1cc2[C@@H](C)C(C)(C)Oc2cc1)\C YXEPEHFXXORWGP-BRAIEQGRSA-N 0.000 description 1
- 241001124076 Aphididae Species 0.000 description 1
- 235000010894 Artemisia argyi Nutrition 0.000 description 1
- 244000267790 Artemisia ludoviciana Species 0.000 description 1
- 208000008035 Back Pain Diseases 0.000 description 1
- JMGZEFIQIZZSBH-UHFFFAOYSA-N Bioquercetin Natural products CC1OC(OCC(O)C2OC(OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5)C(O)C2O)C(O)C(O)C1O JMGZEFIQIZZSBH-UHFFFAOYSA-N 0.000 description 1
- 241000255789 Bombyx mori Species 0.000 description 1
- 241000219193 Brassicaceae Species 0.000 description 1
- 241001119611 Castanospora alphandii Species 0.000 description 1
- QIIDATRCGITYRZ-UHFFFAOYSA-N Catalpol Natural products OCC1OC(OC2OC=CC3C(O)C(=C(CO)C23)O)C(O)C(O)C1O QIIDATRCGITYRZ-UHFFFAOYSA-N 0.000 description 1
- 240000005250 Chrysanthemum indicum Species 0.000 description 1
- LPZCCMIISIBREI-MTFRKTCUSA-N Citrostadienol Natural products CC=C(CC[C@@H](C)[C@H]1CC[C@H]2C3=CC[C@H]4[C@H](C)[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C)C(C)C LPZCCMIISIBREI-MTFRKTCUSA-N 0.000 description 1
- 235000005976 Citrus sinensis Nutrition 0.000 description 1
- 208000002881 Colic Diseases 0.000 description 1
- 206010010741 Conjunctivitis Diseases 0.000 description 1
- 241000125183 Crithmum maritimum Species 0.000 description 1
- 206010011703 Cyanosis Diseases 0.000 description 1
- 240000004784 Cymbopogon citratus Species 0.000 description 1
- 235000017897 Cymbopogon citratus Nutrition 0.000 description 1
- YTBSYETUWUMLBZ-QWWZWVQMSA-N D-threose Chemical compound OC[C@@H](O)[C@H](O)C=O YTBSYETUWUMLBZ-QWWZWVQMSA-N 0.000 description 1
- 208000001840 Dandruff Diseases 0.000 description 1
- 244000000626 Daucus carota Species 0.000 description 1
- 235000002767 Daucus carota Nutrition 0.000 description 1
- ARVGMISWLZPBCH-UHFFFAOYSA-N Dehydro-beta-sitosterol Natural products C1C(O)CCC2(C)C(CCC3(C(C(C)CCC(CC)C(C)C)CCC33)C)C3=CC=C21 ARVGMISWLZPBCH-UHFFFAOYSA-N 0.000 description 1
- 206010014080 Ecchymosis Diseases 0.000 description 1
- 241000132514 Echinops ritro Species 0.000 description 1
- 206010014198 Eczema infantile Diseases 0.000 description 1
- 208000003468 Ehrlich Tumor Carcinoma Diseases 0.000 description 1
- 241000306781 Elionurus muticus Species 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
- FQQRXEYLCZNQFD-UHFFFAOYSA-N Euonymin Natural products CC1OC(OC2=C(Oc3cc(O)cc(O)c3C2=O)c4ccc(O)cc4)(C(O)C(O)C1O)C5OCC(O)C(O)C5O FQQRXEYLCZNQFD-UHFFFAOYSA-N 0.000 description 1
- 241000282326 Felis catus Species 0.000 description 1
- 229930091371 Fructose Natural products 0.000 description 1
- 239000005715 Fructose Substances 0.000 description 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
- 206010017553 Furuncle Diseases 0.000 description 1
- 206010067715 Gastrointestinal sounds abnormal Diseases 0.000 description 1
- 206010048461 Genital infection Diseases 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 208000000616 Hemoptysis Diseases 0.000 description 1
- 208000007514 Herpes zoster Diseases 0.000 description 1
- 240000003857 Holcus lanatus Species 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 description 1
- 206010023126 Jaundice Diseases 0.000 description 1
- SRBFZHDQGSBBOR-HWQSCIPKSA-N L-arabinopyranose Chemical compound O[C@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-HWQSCIPKSA-N 0.000 description 1
- 241000520028 Lamium Species 0.000 description 1
- 235000009199 Lamium album Nutrition 0.000 description 1
- 244000303199 Lamium album Species 0.000 description 1
- 241000404126 Lasiospermum Species 0.000 description 1
- 244000165082 Lavanda vera Species 0.000 description 1
- 235000010663 Lavandula angustifolia Nutrition 0.000 description 1
- 241000245240 Lonicera Species 0.000 description 1
- 208000008930 Low Back Pain Diseases 0.000 description 1
- 208000037093 Menstruation Disturbances Diseases 0.000 description 1
- 206010027339 Menstruation irregular Diseases 0.000 description 1
- 241000878006 Miscanthus sinensis Species 0.000 description 1
- 206010059013 Nocturnal emission Diseases 0.000 description 1
- 235000006484 Paeonia officinalis Nutrition 0.000 description 1
- 244000170916 Paeonia officinalis Species 0.000 description 1
- 235000021314 Palmitic acid Nutrition 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 235000010627 Phaseolus vulgaris Nutrition 0.000 description 1
- 244000046052 Phaseolus vulgaris Species 0.000 description 1
- 241001127637 Plantago Species 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 206010036790 Productive cough Diseases 0.000 description 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 1
- 201000004681 Psoriasis Diseases 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 241001248645 Rungia Species 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- VTWZMKRGBAQGEX-UHFFFAOYSA-N Saponaretin-rhamnosid Natural products CC1OC(OC2C(CO)OC(C(O)C2O)c3c(O)cc4OC(=CC(=O)c4c3O)c5ccc(O)cc5)C(O)C(O)C1O VTWZMKRGBAQGEX-UHFFFAOYSA-N 0.000 description 1
- 208000006268 Sarcoma 180 Diseases 0.000 description 1
- 241000593989 Scardinius erythrophthalmus Species 0.000 description 1
- 241000607764 Shigella dysenteriae Species 0.000 description 1
- 206010040943 Skin Ulcer Diseases 0.000 description 1
- 208000004078 Snake Bites Diseases 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 244000300264 Spinacia oleracea Species 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- OMHUCGDTACNQEX-OSHKXICASA-N Steviolbioside Natural products O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(O)=O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O OMHUCGDTACNQEX-OSHKXICASA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 206010042674 Swelling Diseases 0.000 description 1
- FIAAVMJLAGNUKW-UHFFFAOYSA-N UNPD109131 Natural products OC1C(O)C(O)C(CO)OC1C1=C(O)C(C2C(C(O)C(O)C(CO)O2)O)=C(OC(=CC2=O)C=3C=CC(O)=CC=3)C2=C1O FIAAVMJLAGNUKW-UHFFFAOYSA-N 0.000 description 1
- 206010046788 Uterine haemorrhage Diseases 0.000 description 1
- 244000225942 Viola tricolor Species 0.000 description 1
- 241001106476 Violaceae Species 0.000 description 1
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 229960000643 adenine Drugs 0.000 description 1
- 125000001931 aliphatic group Chemical group 0.000 description 1
- 229930013930 alkaloid Natural products 0.000 description 1
- 150000001336 alkenes Chemical class 0.000 description 1
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- WUOACPNHFRMFPN-UHFFFAOYSA-N alpha-terpineol Chemical compound CC1=CCC(C(C)(C)O)CC1 WUOACPNHFRMFPN-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 230000036592 analgesia Effects 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
- 230000000675 anti-caries Effects 0.000 description 1
- 230000003064 anti-oxidating effect Effects 0.000 description 1
- 230000003356 anti-rheumatic effect Effects 0.000 description 1
- 239000003908 antipruritic agent Substances 0.000 description 1
- 239000003435 antirheumatic agent Substances 0.000 description 1
- 208000002399 aphthous stomatitis Diseases 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 239000010692 aromatic oil Substances 0.000 description 1
- 244000030166 artemisia Species 0.000 description 1
- 239000003212 astringent agent Substances 0.000 description 1
- 201000008937 atopic dermatitis Diseases 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- RJWJHRPNHPHBRN-FKVJWERZSA-N aucubin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@H]1[C@@H]2C(CO)=C[C@@H](O)[C@@H]2C=CO1 RJWJHRPNHPHBRN-FKVJWERZSA-N 0.000 description 1
- UTDFQMAXCUGNJR-UHFFFAOYSA-N aucubin Natural products OCC1OC(Oc2ccoc2C3C(O)CCC3O)C(O)C(O)C1O UTDFQMAXCUGNJR-UHFFFAOYSA-N 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- MJVXAPPOFPTTCA-UHFFFAOYSA-N beta-Sistosterol Natural products CCC(CCC(C)C1CCC2C3CC=C4C(C)C(O)CCC4(C)C3CCC12C)C(C)C MJVXAPPOFPTTCA-UHFFFAOYSA-N 0.000 description 1
- LGJMUZUPVCAVPU-UHFFFAOYSA-N beta-Sitostanol Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(C)CCC(CC)C(C)C)C1(C)CC2 LGJMUZUPVCAVPU-UHFFFAOYSA-N 0.000 description 1
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 description 1
- NJKOMDUNNDKEAI-UHFFFAOYSA-N beta-sitosterol Natural products CCC(CCC(C)C1CCC2(C)C3CC=C4CC(O)CCC4C3CCC12C)C(C)C NJKOMDUNNDKEAI-UHFFFAOYSA-N 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 229940074360 caffeic acid Drugs 0.000 description 1
- 235000004883 caffeic acid Nutrition 0.000 description 1
- 229960001948 caffeine Drugs 0.000 description 1
- VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 239000000496 cardiotonic agent Substances 0.000 description 1
- LHDWRKICQLTVDL-PZYDOOQISA-N catalpol Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@H]1[C@@H]2[C@@]3(CO)O[C@H]3[C@@H](O)[C@@H]2C=CO1 LHDWRKICQLTVDL-PZYDOOQISA-N 0.000 description 1
- UXSACQOOWZMGSE-UHFFFAOYSA-N catalposide Natural products OC1C(O)C(O)C(CO)OC1OC1C2C3(CO)OC3C(OC(=O)C=3C=CC(O)=CC=3)C2C=CO1 UXSACQOOWZMGSE-UHFFFAOYSA-N 0.000 description 1
- 235000005487 catechin Nutrition 0.000 description 1
- ADRVNXBAWSRFAJ-UHFFFAOYSA-N catechin Natural products OC1Cc2cc(O)cc(O)c2OC1c3ccc(O)c(O)c3 ADRVNXBAWSRFAJ-UHFFFAOYSA-N 0.000 description 1
- JLPRGBMUVNVSKP-AHUXISJXSA-M chembl2368336 Chemical compound [Na+].O([C@H]1[C@@H](O)[C@H](O)[C@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C([O-])=O)[C@@H]1O[C@@H](CO)[C@@H](O)[C@H](O)[C@@H]1O JLPRGBMUVNVSKP-AHUXISJXSA-M 0.000 description 1
- 238000001311 chemical methods and process Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 210000000038 chest Anatomy 0.000 description 1
- 229930002875 chlorophyll Natural products 0.000 description 1
- 235000019804 chlorophyll Nutrition 0.000 description 1
- ATNHDLDRLWWWCB-AENOIHSZSA-M chlorophyll a Chemical compound C1([C@@H](C(=O)OC)C(=O)C2=C3C)=C2N2C3=CC(C(CC)=C3C)=[N+]4C3=CC3=C(C=C)C(C)=C5N3[Mg-2]42[N+]2=C1[C@@H](CCC(=O)OC\C=C(/C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)[C@H](C)C2=C5 ATNHDLDRLWWWCB-AENOIHSZSA-M 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 description 1
- 229960001231 choline Drugs 0.000 description 1
- 208000019902 chronic diarrheal disease Diseases 0.000 description 1
- 229950001002 cianidanol Drugs 0.000 description 1
- 229930007050 cineol Natural products 0.000 description 1
- RFFOTVCVTJUTAD-UHFFFAOYSA-N cineole Natural products C1CC2(C)CCC1(C(C)C)O2 RFFOTVCVTJUTAD-UHFFFAOYSA-N 0.000 description 1
- QAIPRVGONGVQAS-UHFFFAOYSA-N cis-caffeic acid Natural products OC(=O)C=CC1=CC=C(O)C(O)=C1 QAIPRVGONGVQAS-UHFFFAOYSA-N 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000006837 decompression Effects 0.000 description 1
- SQIFACVGCPWBQZ-UHFFFAOYSA-N delta-terpineol Natural products CC(C)(O)C1CCC(=C)CC1 SQIFACVGCPWBQZ-UHFFFAOYSA-N 0.000 description 1
- 238000000586 desensitisation Methods 0.000 description 1
- 230000000249 desinfective effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 229910003460 diamond Inorganic materials 0.000 description 1
- 239000010432 diamond Substances 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- IVTMALDHFAHOGL-UHFFFAOYSA-N eriodictyol 7-O-rutinoside Natural products OC1C(O)C(O)C(C)OC1OCC1C(O)C(O)C(O)C(OC=2C=C3C(C(C(O)=C(O3)C=3C=C(O)C(O)=CC=3)=O)=C(O)C=2)O1 IVTMALDHFAHOGL-UHFFFAOYSA-N 0.000 description 1
- 238000012869 ethanol precipitation Methods 0.000 description 1
- PBFGAFDJVQAMRS-KXGLKPECSA-N euonymine Natural products C[C@@H]1[C@H](C)C(=O)O[C@H]2[C@H](OC(=O)C)[C@H](OC(=O)C)[C@@]3(COC(=O)C)[C@H](OC(=O)C)[C@H](OC(=O)C)[C@@H]4[C@H](OC(=O)C)[C@]3(O[C@@]4(C)COC(=O)c5cccnc15)[C@@]2(C)O PBFGAFDJVQAMRS-KXGLKPECSA-N 0.000 description 1
- 238000004880 explosion Methods 0.000 description 1
- 230000004438 eyesight Effects 0.000 description 1
- 210000003608 fece Anatomy 0.000 description 1
- QOLIPNRNLBQTAU-UHFFFAOYSA-N flavan Chemical compound C1CC2=CC=CC=C2OC1C1=CC=CC=C1 QOLIPNRNLBQTAU-UHFFFAOYSA-N 0.000 description 1
- 239000005452 food preservative Substances 0.000 description 1
- 235000019249 food preservative Nutrition 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 208000007565 gingivitis Diseases 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 229930182470 glycoside Natural products 0.000 description 1
- 150000002338 glycosides Chemical class 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 238000009499 grossing Methods 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 208000019622 heart disease Diseases 0.000 description 1
- 208000035861 hematochezia Diseases 0.000 description 1
- 208000006750 hematuria Diseases 0.000 description 1
- 208000014617 hemorrhoid Diseases 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 238000009775 high-speed stirring Methods 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 210000002429 large intestine Anatomy 0.000 description 1
- 239000001102 lavandula vera Substances 0.000 description 1
- 235000018219 lavender Nutrition 0.000 description 1
- 150000002617 leukotrienes Chemical class 0.000 description 1
- 230000031700 light absorption Effects 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000002398 materia medica Substances 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 230000005906 menstruation Effects 0.000 description 1
- 150000004702 methyl esters Chemical class 0.000 description 1
- LHDWRKICQLTVDL-UHFFFAOYSA-N methyl iridoid glycoside Natural products OC1C(O)C(O)C(CO)OC1OC1C2C3(CO)OC3C(O)C2C=CO1 LHDWRKICQLTVDL-UHFFFAOYSA-N 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 1
- 208000004296 neuralgia Diseases 0.000 description 1
- 206010029410 night sweats Diseases 0.000 description 1
- 230000036565 night sweats Effects 0.000 description 1
- XRRQZKOZJFDXON-UHFFFAOYSA-N nitric acid;silver Chemical compound [Ag].O[N+]([O-])=O XRRQZKOZJFDXON-UHFFFAOYSA-N 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 230000000474 nursing effect Effects 0.000 description 1
- 235000021049 nutrient content Nutrition 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 235000008935 nutritious Nutrition 0.000 description 1
- 230000000050 nutritive effect Effects 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 150000007524 organic acids Chemical group 0.000 description 1
- 239000005416 organic matter Substances 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 238000010422 painting Methods 0.000 description 1
- 208000028169 periodontal disease Diseases 0.000 description 1
- 201000001245 periodontitis Diseases 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 206010036067 polydipsia Diseases 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 230000037452 priming Effects 0.000 description 1
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 1
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- FDRQPMVGJOQVTL-UHFFFAOYSA-N quercetin rutinoside Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 FDRQPMVGJOQVTL-UHFFFAOYSA-N 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- MUPFEKGTMRGPLJ-ZQSKZDJDSA-N raffinose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)O1 MUPFEKGTMRGPLJ-ZQSKZDJDSA-N 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 206010039083 rhinitis Diseases 0.000 description 1
- 201000005404 rubella Diseases 0.000 description 1
- IKGXIBQEEMLURG-BKUODXTLSA-N rutin Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@@H]1OC[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 IKGXIBQEEMLURG-BKUODXTLSA-N 0.000 description 1
- ALABRVAAKCSLSC-UHFFFAOYSA-N rutin Natural products CC1OC(OCC2OC(O)C(O)C(O)C2O)C(O)C(O)C1OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5 ALABRVAAKCSLSC-UHFFFAOYSA-N 0.000 description 1
- 235000005493 rutin Nutrition 0.000 description 1
- 229960004555 rutoside Drugs 0.000 description 1
- 230000001835 salubrious effect Effects 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 231100000241 scar Toxicity 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 235000015500 sitosterol Nutrition 0.000 description 1
- 229950005143 sitosterol Drugs 0.000 description 1
- NLQLSVXGSXCXFE-UHFFFAOYSA-N sitosterol Natural products CC=C(/CCC(C)C1CC2C3=CCC4C(C)C(O)CCC4(C)C3CCC2(C)C1)C(C)C NLQLSVXGSXCXFE-UHFFFAOYSA-N 0.000 description 1
- 231100000019 skin ulcer Toxicity 0.000 description 1
- 239000000779 smoke Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 235000014347 soups Nutrition 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 208000024794 sputum Diseases 0.000 description 1
- 210000003802 sputum Anatomy 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 150000003432 sterols Chemical class 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 239000001648 tannin Substances 0.000 description 1
- 235000018553 tannin Nutrition 0.000 description 1
- 229920001864 tannin Polymers 0.000 description 1
- BWMISRWJRUSYEX-SZKNIZGXSA-N terbinafine hydrochloride Chemical compound Cl.C1=CC=C2C(CN(C\C=C\C#CC(C)(C)C)C)=CC=CC2=C1 BWMISRWJRUSYEX-SZKNIZGXSA-N 0.000 description 1
- 229930006978 terpinene Natural products 0.000 description 1
- 150000003507 terpinene derivatives Chemical class 0.000 description 1
- 229940116411 terpineol Drugs 0.000 description 1
- 201000004647 tinea pedis Diseases 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 230000008736 traumatic injury Effects 0.000 description 1
- 201000002327 urinary tract obstruction Diseases 0.000 description 1
- 229940096998 ursolic acid Drugs 0.000 description 1
- PLSAJKYPRJGMHO-UHFFFAOYSA-N ursolic acid Natural products CC1CCC2(CCC3(C)C(C=CC4C5(C)CCC(O)C(C)(C)C5CCC34C)C2C1C)C(=O)O PLSAJKYPRJGMHO-UHFFFAOYSA-N 0.000 description 1
- 238000009777 vacuum freeze-drying Methods 0.000 description 1
- 231100000611 venom Toxicity 0.000 description 1
- MVOUGOXRXQDXDC-RSPRXDBDSA-N violanthin Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1C1=C(O)C([C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)=C(O)C2=C1OC(C=1C=CC(O)=CC=1)=CC2=O MVOUGOXRXQDXDC-RSPRXDBDSA-N 0.000 description 1
- MVOUGOXRXQDXDC-NMJPTQROSA-N violanthin Natural products O=C1c2c(O)c([C@H]3[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O3)c(O)c([C@H]3[C@H](O)[C@@H](O)[C@@H](O)[C@H](C)O3)c2OC(c2ccc(O)cc2)=C1 MVOUGOXRXQDXDC-NMJPTQROSA-N 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Zoology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
本发明提供一种含有中药活性物质和茶树精油液体口腔用组合物,按重量份计算,包括:中药提取物1.0~10份,添加剂0.1~6份,薄荷醇0.001~0.005份,茶树精油0.001~0.006份,水90~100份;其中,所述中药提取物包括绿茶提取物,鼠曲草提取物,车前草提取物,短柄野芝麻提取物,茶树根提取物,五倍子、金银花及橙皮混合提取物,紫罗兰提取物;所述添加剂包括润湿剂、pH调节剂、防腐剂、香精和絮凝剂。
Description
技术领域
本发明涉及口腔护理品技术领域,更具体地,本发明提供一种含有中药活性物质和茶树精油液体口腔用组合物。
背景技术
液体口腔用组合物中漱口水是人们日常生活清洁及保健的口腔护理品,主要用于保持口腔和牙齿清洁、促进口气清新、护理牙龈、维护口腔良好微环境等。
目前,市场上日常用的中药漱口水种类很多,其主要是在组成漱口水的漱口水水体基质中添加相应的中药成分来形成中药漱口水,其用来多能抑制口腔有害细菌,消炎镇痛,防本脱敏,预防龋齿,防治牙龈炎,牙周炎,牙出血等牙周疾病。
为了赋予清爽的使用感,漱口水中通常混合乙醇。但是,乙醇会伴随有口腔内的刺激,容易造成口腔粘膜的白色病变,会影响酒精测试浓度,不适合用于出外聚餐后的口腔消毒。
另外,对于非乙醇类漱口水中,乳剂容易崩解,影响漱口水的外观稳定性和漱口水的使用性。
茶树精油具有杀菌消炎,可去除口腔异味,防止蛀牙,保持口气清新。
因此,针对上述存在的问题,亟需一种能够口腔和牙齿清洁、促进口气清新、护理牙龈、维护口腔良好微环境,且具有很好的外观稳定性及使用性的非乙醇类含茶树精油的液体口腔用组合物。
发明内容
本发明第一方面提供一种含有中药活性物质和茶树精油液体口腔用组合物,按重量份计算,包括:
其中,所述中药提取物包括绿茶提取物,鼠曲草提取物,车前草提取物,短柄野芝麻提取物,茶树根提取物,五倍子、金银花及橙皮混合提取物,紫罗兰提取物;所述添加剂包括润湿剂、pH调节剂、防腐剂、香精和絮凝剂。
在一种实施方式中,所述中药提取物还包括薄荷提取物、甜叶菊提取物、三色堇提取物、藏茴香提取物。
在一种实施方式中,所述润湿剂包括山梨糖醇、木糖醇、麦芽糖醇、乳糖醇、乙二醇中一种或多种。
在一种实施方式中,所述pH调节剂包括邻苯二甲酸、磷酸、柠檬酸、琥珀酸、乙酸、富马酸、苹果酸、碳酸、磷酸二氢钠、磷酸一氢钠、柠檬酸钠中一种或多种。
在一种实施方式中,所述防腐剂包括苯甲酸钠、对羟基苯甲酸甲酯、对羟基苯甲酸乙酯、对羟基苯甲酸丙酯、对羟基苯甲酸丁酯等对羟基苯甲酸酯、甘氨酸烷基二氨基乙酯盐酸盐、山梨酸钾、蜂胶中一种或多种。
在一种实施方式中,所述香精包括留兰香油、桉树油、冬青油、丁香油、百里香油、鼠尾草油、小豆蔻油、迷迭香油、马郁兰油、柠檬油、肉豆蔻油、薰衣草油、天神草油、L-香芹酮、1,8-桉树脑、水杨酸甲酯、丁香酚、百里酚、芳樟醇、柠檬烯、薄荷酮、乙酸薄荷酯、柠檬醛、樟脑、冰片、蒎烯、千日菊素中一种或多种。
在一种实施方式中,所述絮凝剂为改性氯化钙,所述改性氯化钙为丙烯酸包覆氯化钙后接枝壳聚糖。
在一种实施方式中,所述改性氯化钙的接枝率为1~5%。
在一种实施方式中,所述改性氯化钙的接枝率为1~3%。
本发明另一方面提供一种含有中药活性物质和茶树精油液体口腔用组合物的制备方法,包括以下步骤:
(1)按重量份加入中药提取物,薄荷醇,茶树精油和水,搅拌,使所述中药提取物溶解于水中;
(2)按重量份加入添加剂,充分搅拌,过滤,取滤液,经杀菌处理,得到所述含有中药活性物质和茶树精油液体口腔用组合物。
参考以下详细说明更易于理解本申请的上述以及其他特征、方面和优点。
具体实施方式
参选以下本发明的优选实施方法的详述以及包括的实施例可更容易地理解本发明的内容。除非另有限定,本文使用的所有技术以及科学术语具有与本发明所属领域普通技术人员通常理解的相同的含义。当存在矛盾时,以本说明书中的定义为准。
如本文所用术语“由…制备”与“包含”同义。本文中所用的术语“包含”、“包括”、“具有”、“含有”或其任何其它变形,意在覆盖非排它性的包括。例如,包含所列要素的组合物、步骤、方法、制品或装置不必仅限于那些要素,而是可以包括未明确列出的其它要素或此种组合物、步骤、方法、制品或装置所固有的要素。
连接词“由…组成”排除任何未指出的要素、步骤或组分。如果用于权利要求中,此短语将使权利要求为封闭式,使其不包含除那些描述的材料以外的材料,但与其相关的常规杂质除外。当短语“由…组成”出现在权利要求主体的子句中而不是紧接在主题之后时,其仅限定在该子句中描述的要素;其它要素并不被排除在作为整体的所述权利要求之外。
当量、体积分数、或者其它值或参数以范围、优选范围、或一系列上限优选值和下限优选值限定的范围表示时,这应当被理解为具体公开了由任何范围上限或优选值与任何范围下限或优选值的任一配对所形成的所有范围,而不论该范围是否单独公开了。例如,当公开了范围“1至5”时,所描述的范围应被解释为包括范围“1至4”、“1至3”、“1至2”、“1至2和4至5”、“1至3和5”等。当数值范围在本文中被描述时,除非另外说明,否则该范围意图包括其端值和在该范围内的所有整数和分数。
单数形式包括复数讨论对象,除非上下文中另外清楚地指明。“任选的”或者“任意一种”是指其后描述的事项或事件可以发生或不发生,而且该描述包括事件发生的情形和事件不发生的情形。
说明书和权利要求书中的近似用语用来修饰数量,表示本发明并不限定于该具体数量,还包括与该数量接近的可接受的而不会导致相关基本功能的改变的修正的部分。相应的,用“大约”、“约”等修饰一个数值,意为本发明不限于该精确数值。在某些例子中,近似用语可能对应于测量数值的仪器的精度。在本申请说明书和权利要求书中,范围限定可以组合和/或互换,如果没有另外说明这些范围包括其间所含有的所有子范围。
此外,本发明要素或组分前的不定冠词“一种”和“一个”对要素或组分的数量要求(即出现次数)无限制性。因此“一个”或“一种”应被解读为包括一个或至少一个,并且单数形式的要素或组分也包括复数形式,除非所述数量明显旨指单数形式。
“共混物”意指两种或两种以上聚合物通过物理的或化学的方法共同混合而形成的聚合物。
本发明第一方面提供一种含有中药活性物质和茶树精油液体口腔用组合物,按重量份计算,包括:
其中,所述中药提取物包括绿茶提取物,鼠曲草提取物,车前草提取物,短柄野芝麻提取物,茶树根提取物,五倍子、金银花及橙皮混合提取物,紫罗兰提取物;所述添加剂包括润湿剂、pH调节剂、防腐剂、香精和絮凝剂。
在一种实施方式中,所述中药提取物还包括薄荷提取物、甜叶菊提取物、三色堇提取物、藏茴香提取物。
在一种实施方式中,按重量份计算,所述中药提取物中绿茶提取物1~2份,鼠曲草提取物0.1~1份,车前草提取物0.1~1份,短柄野芝麻提取物0.5~1.5份,茶树根提取物0.1~1.0份,五倍子、金银花及橙皮混合提取物0.5~3份,紫罗兰提取物0.01~0.1份,薄荷提取物0.1~1.2份、甜叶菊提取物0.05~1.0份、三色堇提取物0.003~0.2份、藏茴香提取物0.005~0.3份。
在一种实施方式中,按重量份计算,所述润湿剂1~5份,pH调节剂0.1~0.3份、防腐剂0.01~0.1份、香精0.001~0.1份和絮凝剂0.01~0.15份。
绿茶
绿茶是未经发酵制成的茶,保留了鲜叶的天然物质,含有的茶多酚、儿茶素、叶绿素、咖啡碱、氨基酸、维生素等营养成分也较多。绿茶中的这些天然营养成份对防衰老、防癌、抗癌、杀菌、消炎等具有特殊效果。绿茶是以适宜茶树新梢为原料,经杀青、揉捻、干燥等典型工艺过程制成的茶叶。
鼠曲草
别名:黄花曲草、清明菜、田艾、佛耳草、土菌陈[广东]、酒曲绒、鼠耳、无心草、鼠耳草、香茅、蚍蜉酒草、黄花白艾、茸母、黄蒿、米曲、毛耳朵、水菊、绵絮头草、金沸草、地莲、黄花子草、水蚁草、清明香、追骨风、棉花菜、菠菠草、棉茧头、宽紧草、清明蒿、一面青、鼠密艾、水蒿、靶菜、白头草、水曲、绒毛草、丝棉草、羊耳朵草、猫耳朵草、孩儿草、猫脚药草、花佛草、毛毛头草、黄花果、糯米饭青、棉菜、白芒草、毛毡草。全草含5%黄酮甙,0.05%挥发油,微量生物碱和甾醇,0.58%非扛化物,又含维生素B,胡萝卜,叶绿素,树脂,脂肪等。花含木犀草素-4-β-D-葡萄糖甙(luteline-4-β-D-glucoside)
性味归经:甘,平。
功能主治:止咳平喘,降血压,祛风湿。用于感冒咳嗽,支气管炎,哮喘,高血压,蚕豆病,风湿腰腿痛;外用治跌打损伤,毒蛇咬伤。
车前草
全草含车前甙(Plantago astiatice L)桃叶珊瑚甙(Aucnbin).乌苏酸(Uraolicacid).B-谷甾醇、正三十一烷、棕榈酸B-谷甾酸酯、棕酸豆甾醇酯、维生素B、维生素C、以及车前果胶(Plantaglusidc)(系由D-半乳醛酸甲酯.D-半糖、L-***糖、L-鼠李糖等组成)。蛋白质、琥珀酸、腺嘌呤、胆硷、梓醇、硬质酸、花生酸、亚麻酸、亚没酸等脂肪酸。
性味和功用:甘,寒,归手太阳,阳明经。利水,清热,明目,祛痰,用于小便不通,淋浊,带下,尿血,黄疸,水肿,热痢泄泻,鼻衄,目赤肿痛,喉痛,咳嗽,皮肤溃疡。
短柄野芝麻
短柄野芝麻(学名:Lamium album)为唇形科野芝麻属下的一个植物种。幼叶可食,花可入药,全草含皂甙,鞣质,咖啡酸和多种氨基酸。
性味和功用:甘、苦,凉。入肝、肾、膀胱三经。活血祛瘀,消肿止痛。
茶树根
新鲜根含水苏糖、棉子糖、蔗糖、葡萄糖、果糖等糖类,并含少量多酚化合物(黄烷醇等)。
性味和功用:苦;凉。入心;肾经。强心利尿;活血调经;清热解毒。主心脏病;水肿;肝炎;痛经;疮疡肿毒;口疮;汤火灼伤;带状疱疹;牛皮癣。
五倍子
五倍子角倍呈菱形或卵圆形,具不规则角状分枝,长3-8厘米,直径2-5厘米。表面黄色或淡黄棕色,灰白色软滑短绒毛较明显。质硬而脆,破碎后中空,壁较薄,约0.1-0.2厘米,角质,内有多数黑褐色蚜虫尸体及灰色粉状***物。内壁浅棕色,平滑。剖面角质。微有特异臭气,味涩。
药性:酸,涩,寒。归肺、大肠、肾经。
功效:敛肺降火,止咳止汗,涩肠止泻,固精止遗,收敛止血,收湿敛疮。
主治:咳嗽,咳血,自汗,盗汗,久泻,久痢,遗精,滑精,崩漏,便血痔血,湿疮,肿毒。
金银花
金银花,又名忍冬、银花、双花等,自古被誉为清热解毒的良药。它性甘寒气芳香,甘寒清热而不伤胃,芳香透达又可祛邪。金银花既能宣散风热,还善清解血毒,用于各种热性病,如身热、发疹、发斑、热毒疮痈、咽喉肿痛等证,均效果显著。根据2005年版《中国药典》,金银花为忍冬科忍冬属植物忍冬(Lonicerajaponica Thunb)的干燥花蕾或带初开的花。
金银花具有广谱抗菌作用,对金黄色葡萄球菌、痢疾杆菌等致病菌有较强的抑制作用;有明显抗炎及解热作用;金银花的水及酒浸液对肉瘤180及艾氏腹水瘤有明显的细胞毒作,还具有一定降低胆固醇作用。
性味归经:甘,寒。归肺、心、胃经。
功效应用:清热解毒,疏散风热。主治痈肿疔毒初起,红肿热痛,外感风热,温病初起,热毒血痢,暑热烦渴,咽喉肿痛。
紫罗兰
紫罗兰,拉丁文学名:(Matthiola incana(L.)R.Br.)十字花科,紫罗兰属二年生或多年生草本。全株密被灰白色具柄的分枝柔毛。茎直立,多分枝,基部稍木质化。叶片长圆形至倒披针形或匙形。
紫罗兰能够清热解毒,美白祛斑,滋润皮肤,除皱消斑,清除口腔异味,增强光泽,防紫外线照射,紫罗兰对呼吸道的帮助很大,对支气管炎也有调理之效,还可以润喉,以及解决因蛀牙引起的口腔异味。
薄荷
薄荷,土名叫“银丹草”,为唇形科植物“薄荷”即同属其他干燥全草,多生于山野湿地河旁,根茎横生地下。全株青气芳香。叶对生,花小淡紫色,唇形,花后结暗紫棕色的小粒果。
薄荷具有特殊的芳香、辛辣感和凉感,用于驱风、防腐、消炎、镇痛、止痒、健胃等药品中。全草入药,辛,凉。归肺、肝经,有发散风热,清利咽喉,透疹解毒,疏肝解郁和止痒等功效,适用于感冒发热、头痛、咽喉肿痛、无汗、风火赤眼、风疹、皮肤发痒、疝痛、下痢及瘰疬等症,外用有轻微的止痛作用,用于神经痛等。
甜叶菊
叶含甜菊甙、甜菊双糖甙、甜菊甙A和甜菊甙B、甜甙A、甜甙B、甜甙C、D、E、卫矛甙A、6-O-乙酰基澳泽兰素、泽兰醇、澳泽兰素。
性味归经:甘,寒;归肺、胃二经。
功效作用:生津止渴;降血压。主消渴;高血压病。
橙皮
橙皮为芸香科植物甜橙的果皮。甜橙常绿小乔木,栽培于丘陵、低山地带和江河湖泊沿岸,我国长江以南各地均有栽培,品种众多。冬季或春初,剥下来的果皮,晒干或烘干。
性味归经:性温,味甘苦,无毒;入脾、肺二经。
功效作用:理气,化痰,健脾,导滞。治感冒咳嗽,食欲不振,胸腹胀痛,肠鸣便泻,乳痈。
三色堇
三色堇(学名:Viola tricolor L.)是堇菜科堇菜属的一年生或短期多年生草本植物。茎、叶含三色堇黄甙;花含芸香甙、挥发油、皂甙、维生素A、C。三色堇可杀菌、治疗皮肤上青春痘、粉刺、过敏问题。中医圣典《本草纲目》详细内载三色堇的神奇去痘功效:“三色堇,性表温和,其味芳香,引药上行于面,去疮除疤,疮疡消肿。”三色堇全草,可以用作药物,茎叶含三色堇素,主治咳嗽等疾病。
性味归经:寒、苦;归经、肺经。
功效作用:清热解毒;止咳。主疮疡肿毒;小儿湿疹;小儿瘰疬;咳嗽。
藏茴香
藏茴香为伞形科植物蕡蒿的果实。果实含挥发油称藏茴香油3.5~7%,油中主要成分为d-葛缕酮50~60%和d-柠椽烯等。
性味归经:性温,味甘辛;入肾、胃经。
功效作用:芳香健胃,驱风理气。治胃痛,腹痛,小肠疝气。
绿茶提取物提取方法:
茶多糖:取粉碎后茶样20g,用预热至55℃的蒸馏水以1:20(w/v)的比例于55℃的水浴锅中搅拌浸提2.5h,过滤后以4000r/min的速度离心15min,取上清液,浓缩,然后用3倍体积的95%乙醇沉淀,离心得茶多糖沉淀,冷冻干燥后得茶多糖。
茶多酚:取粉碎后茶样20g,用预热至55℃的蒸馏水以1:20(w/V)的比例于55℃的水浴锅中搅拌浸提2.5h,过滤后以400Or/min的速度离心15min,取上清液,浓缩,用A13+在pH5.3-5.7环境中沉淀茶多酚,茶多酚-铝沉淀经转溶,等体积乙酸乙酯萃取3次,真空冷冻干燥后得茶多酚(I);再取适量上清液,浓缩,等体积乙酸乙酯萃取3次,真空冷冻干燥后得茶多酚(II)。
鼠曲草提取物提取方法:
称取20.0g鼠曲草干燥并进行粉碎后,加入质量浓度为70%~80%的乙醇,浸泡2~3h后使用微波加热提取2~3次,过滤,滤液经减压浓缩至无乙醇,即得。
车前草提取物提取方法:
称取20.0g车前草干燥并进行粉碎后,加入质量浓度为80%~90%的乙醇,浸泡2~3h后使用微波加热提取2~3次,过滤,滤液经减压浓缩至无乙醇,即得。
短柄野芝麻提取物提取方法:
将短柄野芝麻花洗净、切碎,然后加入质量浓度为3~5g/L柠檬酸水溶液,浸泡2~3h后使用微波加热提取2~3次,过滤,滤液经减压干燥,即得。
茶树根提取物提取方法:
称取20.0g茶树根,洗净、干燥并进行粉碎后,加入质量浓度为75%~85%的乙醇,浸泡2~3h后使用微波加热提取2~3次,过滤,滤液经减压浓缩至无乙醇,即得。
紫罗兰提取物提取方法:
称取干燥的紫罗兰20.0g,粉碎后,加入100℃的热水中,浸泡1h,然后再加入浓度为80%~85%的乙醇,使用微波加热提取1~3次,微波功率为80~100W,过滤,滤液经减压浓缩至无乙醇,即得。
薄荷提取物提取方法:
取薄荷,粉碎成粗粉,置于超临界CO2萃取装置,在解析压力6MPa,解析温度35℃,萃取时间3.0h,萃取温度45℃,萃取压力35MPa,CO2流量40kg/h,得到薄荷提取物。
甜叶菊提取物提取方法:
取甜叶菊,粉碎成粗粉,置于超临界CO2萃取装置,在解析压力6MPa,解析温度40℃,萃取时间3.0h,萃取温度55℃,萃取压力40MPa,CO2流量50kg/h,得到甜叶菊提取物。
五倍子、金银花及橙皮混合提取物提取方法:
将五倍子、金银花及橙皮按重量比混合,***粉碎至100-200目,和0.1重量份的2-巯基苯并噻唑共混,用乙醇作为溶剂进行提取,回流2h,趁热过滤,浓缩至无乙醇,即得。
在一种实施方式中,所述五倍子与金银花、橙皮的重量比为1:0.3:0.2。
三色堇提取物提取方法:
称取干燥的三色堇20.0g,粉碎后,加入90℃的热水中,浸泡2h,然后再加入浓度为75%~85%的乙醇,使用微波加热提取1~3次,微波功率为80~100W,过滤,滤液经减压浓缩至无乙醇,即得。
藏茴香提取物提取方法:
称取干燥的藏茴香20.0g,粉碎后,加入100℃的热水中,浸泡2h,然后再加入浓度为95%的乙醇,使用微波加热提取1~3次,微波功率为80~100W,过滤,滤液经减压浓缩至无乙醇,即得。
在一种实施方式中,所述润湿剂包括山梨糖醇、木糖醇、麦芽糖醇、乳糖醇、乙二醇中一种或多种。
茶树精油
茶树精油原产于澳洲,为茶树的提取物。具有杀菌消炎、收敛毛孔、治疗伤风感冒、咳嗽、鼻炎、哮喘,改善痛经、***及生殖器感染等功效。适用于油性及粉刺皮肤,治疗化脓伤口及灼伤、晒伤、香港脚及头屑。使头脑清醒,恢复活力,抗沮丧。
最主要的化学成分为对孟乙烯(terpinene)、松油精(pinene)、柠檬油精(limonene)、桉油酚(cineole)、香油脑(terpineol)、茴香素(cumene)。
其提取方法是以叶片和嫩梢为原料的,采用蒸汽蒸馏法提取,出油率是1.8%。
pH调节剂
pH值调节剂亦称pH调节剂,酸度调节剂或pH值控制剂等,使用来调整或保持pH值(酸或碱)的一种食品添加剂。酸度调节剂可以是有机酸或无机酸,碱,中和剂或缓冲剂。
酸度调节剂具有增进食品质量的许多功能特性,例如改变和维持食品的酸度并改善其风味;增进抗氧化作用,防止食品酸败;与重金属离子络合,具有阻止氧化或褐变反应、稳定颜色、降低浊度、增强胶凝特性等作用。
在一种实施方式中,所述pH调节剂包括邻苯二甲酸、磷酸、柠檬酸、琥珀酸、乙酸、富马酸、苹果酸、碳酸、磷酸二氢钠、磷酸一氢钠、柠檬酸钠中一种或多种;优选地,所述pH调节剂为柠檬酸、柠檬酸钠。
在一种实施方式中,所述柠檬酸与所述柠檬酸钠的重量比为1:0.8。
防腐剂
防腐剂是指天然或合成的化学成分,用以保持食品原有品质和营养价值为目的的食品添加剂。防腐剂主要作用是抑制微生物的生长和繁殖,以延长食品的保存时间,抑制物质腐败的药剂。食品防腐剂能抑制微生物活动,防止食品腐败变质,从而延长食品的保质期。
在一种实施方式中,所述防腐剂包括苯甲酸钠、对羟基苯甲酸甲酯、对羟基苯甲酸乙酯、对羟基苯甲酸丙酯、对羟基苯甲酸丁酯等对羟基苯甲酸酯、甘氨酸烷基二氨基乙酯盐酸盐、山梨酸钾、蜂胶中一种或多种;优选地,所述防腐剂为蜂胶。
香精
香精是由人工合成的模仿水果和天然香料气味的浓缩芳香油。
在一种实施方式中,所述香精包括留兰香油、桉树油、冬青油、丁香油、百里香油、鼠尾草油、小豆蔻油、迷迭香油、马郁兰油、柠檬油、肉豆蔻油、薰衣草油、天神草油、L-香芹酮、1,8-桉树脑、水杨酸甲酯、丁香酚、百里酚、芳樟醇、柠檬烯、薄荷酮、乙酸薄荷酯、柠檬醛、樟脑、冰片、蒎烯、千日菊素中一种或多种;优选地,所述香精包括留兰香油、桉树油、冬青油、丁香油、百里香油、鼠尾草油、小豆蔻油、迷迭香油、马郁兰油、柠檬油、肉豆蔻油、薰衣草油、天神草油、柠檬烯的一种或多种;更优选地,所述香精为柠檬油、柠檬烯的一种或多种。
在一种实施方式中,所述絮凝剂为改性氯化钙,所述改性氯化钙为丙烯酸包覆氯化钙后接枝壳聚糖。
在一种实施方式中,所述改性氯化钙的接枝率为1~5%。
在一种实施方式中,所述改性氯化钙的接枝率为1~3%。
在一种实施方式中,所述改性氯化钙的制备方法如下:
(1)将氯化钙加入料桶温度为50℃高速混合机中,按重量比加入丙烯酸,搅拌0.5~2h后,出料,把高速混合机料桶温度升至120℃后,将上述物料倒回高速混合机中,高速搅拌0.5~1h后出料,得到丙烯酸包覆氯化钙;所述丙烯酸与所述氯化钙的重量比为1:(10~20);
(2)将壳聚糖充分溶解在水中,制成壳聚糖浓度为0.02mol/L的水溶液,向壳聚糖水溶液加入步骤(1)中所述丙烯酸氯化钙和多聚磷酸,50~80℃下,反应10~20h,透析冻干后得到改性氯化钙;所述丙烯酸氯化钙与所述多聚磷酸的重量比为1:(8~15)。
本发明通过改性氯化钙不仅改善液体口腔用组合物的抑菌效果还能维护液体口腔用组合物的稳定性,避免了物质的分层。
本发明中,在15~30℃条件下,所述改性氯化钙在水中的溶解度0.5g。
本发明通过丙烯酸AA的反应活性很高,其一端是强酸性的羧基,可与氯化钙表面发生键合,丙烯酸结合在具有多孔结构的氯化钙表面,具有很好抑菌效果的壳聚糖与丙烯酸氯化钙进行接枝反应,得到的改性氯化钙表面覆盖有机物含有羧基、羟基、氨基等的极性基团,使改性氯化钙具有表面亲油、亲水基团,不仅能够很好的改善液体口腔用组合物的稳定性,还具有很好的抑菌效果。
本发明另一方面提供一种含有中药活性物质和茶树精油液体口腔用组合物的制备方法,包括以下步骤:
(1)按重量份加入中药提取物,薄荷醇,茶树精油和水,搅拌,使所述中药提取物溶解于水中;
(2)按重量份加入添加剂,充分搅拌,过滤,取滤液,经杀菌处理,得到所述含有中药活性物质和茶树精油液体口腔用组合物。
在一种实施方式中,所述杀菌处理为采用高温瞬时灭菌。
高温瞬时灭菌
高温瞬时灭菌,是指利用加热条件下的饱和蒸汽使培养基温度迅速达到130~140℃,维持几分钟后较快地冷却到培养温度,完成灭菌的过程。它的优点是既能杀死较耐热的微生物孢子又可最大限度地减少营养成分的破坏,提高原料的利用率。
本发明中绿茶提取物、鼠曲草提取物、短柄野芝麻提取物、茶树根提取物、五倍子提取物、金银花提取物、薄荷提取物能够清晰口气,杀菌消炎;紫罗兰提取物、甜叶菊提取物、橙皮提取物、三色堇提取物、藏茴香提取物调节口感。
本发明中含有中药提取物的液体口腔用组合物不仅口感极佳,缓解口腔不适症状,保持良好的微生态,并且还具有消炎止痛的功效;本发明避免了酒精容易造成口腔粘膜的白色病变,以及使用液体口腔用组合物口影响酒精测试浓度,特别适合用于出外聚餐后的口腔消毒。
下面通过实施例对本发明进行具体描述。有必要在此指出的是,以下实施例只用于对本发明作进一步说明,不能理解为对本发明保护范围的限制,该领域的专业技术人员根据上述本发明的内容做出的一些非本质的改进和调整,仍属于本发明的保护范围。
另外,如果没有其它说明,所用原料都是市售的,购于国药化学试剂。
实施例1
所述含有中药活性物质和茶树精油液体口腔用组合物的制备方法,包括以下步骤:
(1)按重量份加入中药提取物,薄荷醇,茶树精油和水,搅拌,使所述中药提取物溶解于水中;
(2)按重量份加入添加剂,充分搅拌,过滤,取滤液,经杀菌处理,得到所述含有中药活性物质和茶树精油液体口腔用组合物。
所述含有中药活性物质和茶树精油液体口腔用组合物,按重量份计算,包括:绿茶提取物1.6份,鼠曲草提取物0.7份,车前草提取物0.5份,短柄野芝麻提取物1.0份,茶树根提取物0.6份,五倍子、金银花及橙皮混合提取物2.3份,紫罗兰提取物0.02份,薄荷提取物0.35份、甜叶菊提取物0.12份、三色堇提取物0.005份、藏茴香提取物0.007份,所述木糖醇3.1份,柠檬酸和柠檬酸钠0.15份、蜂胶0.05份、柠檬烯和柠檬油0.003份和改性氯化钙0.06份,薄荷醇0.002份,茶树精油0.003份,水92份;所述五倍子与金银花、橙皮的重量比为1:0.3:0.2;所述柠檬酸与所述柠檬酸钠的重量比为1:0.8;所述柠檬烯与所述柠檬油的重量比为1:0.6。
所述改性氯化钙的制备方法包括如下步骤:
(1)将氯化钙加入料桶温度为50℃高速混合机中,按重量比加入丙烯酸,搅拌1h后,出料,把高速混合机料桶温度升至120℃后,将上述物料倒回高速混合机中,高速搅拌1h后出料,得到丙烯酸包覆氯化钙;所述丙烯酸与所述氯化钙的重量比为1:13;
(2)将壳聚糖充分溶解在水中,制成壳聚糖浓度为0.02mol/L的水溶液,向壳聚糖水溶液加入步骤(1)中所述丙烯酸氯化钙和多聚磷酸,60℃下,反应18h,透析冻干后得到改性氯化钙;所述丙烯酸氯化钙与所述多聚磷酸的重量比为1:10。
实施例2
所述含有中药活性物质和茶树精油液体口腔用组合物,按重量份计算,包括:绿茶提取物2份,鼠曲草提取物0.1份,车前草提取物0.1份,短柄野芝麻提取物0.5份,茶树根提取物0.1份,五倍子、金银花及橙皮混合提取物3份,紫罗兰提取物0.02份,薄荷提取物1份、甜叶菊提取物0.12份、三色堇提取物0.003份、藏茴香提取物0.1份,所述木糖醇3.1份,柠檬酸和柠檬酸钠0.15份、蜂胶0.05份、柠檬烯和柠檬油0.003份和改性氯化钙0.06份,薄荷醇0.002份,茶树精油0.003份,水92份;所述五倍子与金银花、橙皮的重量比为1:0.3:0.2;所述柠檬酸与所述柠檬酸钠的重量比为1:0.8;所述柠檬烯与所述柠檬油的重量比为1:0.6。
所述含有中药活性物质和茶树精油液体口腔用组合物的制备方法和所述改性氯化钙的制备方法同实施例1。
实施例3
所述含有中药活性物质和茶树精油液体口腔用组合物,按重量份计算,包括:绿茶提取物2份,鼠曲草提取物1份,车前草提取物1份,短柄野芝麻提取物1.5份,茶树根提取物0.6份,五倍子、金银花及橙皮混合提取物0.5份,紫罗兰提取物0.05份,薄荷提取物0.1份、甜叶菊提取物0.12份、三色堇提取物0.005份、藏茴香提取物0.007份,所述木糖醇3.1份,柠檬酸和柠檬酸钠0.15份、蜂胶0.05份、柠檬烯和柠檬油0.003份和改性氯化钙0.06份,薄荷醇0.002份,茶树精油0.003份,水92份;所述五倍子与金银花、橙皮的重量比为1:0.3:0.2;所述柠檬酸与所述柠檬酸钠的重量比为1:0.8;所述柠檬烯与所述柠檬油的重量比为1:0.6。
所述含有中药活性物质和茶树精油液体口腔用组合物的制备方法和所述改性氯化钙的制备方法同实施例1。
实施例4
所述含有中药活性物质和茶树精油液体口腔用组合物,按重量份计算,包括:绿茶提取物1.6份,鼠曲草提取物0.7份,车前草提取物0.5份,短柄野芝麻提取物1.0份,茶树根提取物0.6份,金银花提取物2.3份,紫罗兰提取物0.02份,薄荷提取物0.35份、甜叶菊提取物0.12份、三色堇提取物0.003份、藏茴香提取物0.007份,所述木糖醇3.1份,柠檬酸和柠檬酸钠0.15份、蜂胶0.05份、柠檬烯和柠檬油0.003份和改性氯化钙0.06份,薄荷醇0.002份,茶树精油0.003份,水92份;所述柠檬酸与所述柠檬酸钠的重量比为1:0.8;所述柠檬烯与所述柠檬油的重量比为1:0.6。
所述金银花提取物提取方法:
称取20.0g金银花干燥并进行粉碎后,加入质量浓度为85%~95%的乙醇,浸泡2~3h后使用微波加热提取2~3次,过滤,滤液经减压浓缩至无乙醇,即得。
所述含有中药活性物质和茶树精油液体口腔用组合物的制备方法和所述改性氯化钙的制备方法同实施例1。
实施例5
所述含有中药活性物质和茶树精油液体口腔用组合物,按重量份计算,包括:绿茶提取物1.6份,鼠曲草提取物0.7份,车前草提取物0.5份,短柄野芝麻提取物1.0份,茶树根提取物0.6份,五倍子提取物2.3份,紫罗兰提取物0.02份,薄荷提取物0.35份、甜叶菊提取物0.12份、三色堇提取物0.003份、藏茴香提取物0.007份,所述木糖醇3.1份,柠檬酸和柠檬酸钠0.15份、蜂胶0.05份、柠檬烯和柠檬油0.003份和改性氯化钙0.06份,薄荷醇0.002份,茶树精油0.003份,水92份;所述柠檬酸与所述柠檬酸钠的重量比为1:0.8;所述柠檬烯与所述柠檬油的重量比为1:0.6。
所述五倍子提取物提取方法:
称取20.0g五倍子洗净、干燥并进行粉碎后,加入质量浓度为70%~85%的乙醇,浸泡2~3h后使用微波加热提取2~3次,过滤,滤液经减压浓缩至无乙醇,即得。
所述含有中药活性物质和茶树精油液体口腔用组合物的制备方法和所述改性氯化钙的制备方法同实施例1。
实施例6
所述含有中药活性物质和茶树精油液体口腔用组合物,按重量份计算,包括:绿茶提取物1.6份,鼠曲草提取物0.7份,车前草提取物0.5份,短柄野芝麻提取物1.0份,茶树根提取物0.6份,橙皮提取物2.3份,紫罗兰提取物0.02份,薄荷提取物0.35份、甜叶菊提取物0.12份、三色堇提取物0.003份、藏茴香提取物0.007份,所述木糖醇3.1份,柠檬酸和柠檬酸钠0.15份、蜂胶0.05份、柠檬烯和柠檬油0.003份和改性氯化钙0.06份,薄荷醇0.002份,茶树精油0.003份,水92份;所述柠檬酸与所述柠檬酸钠的重量比为1:0.8;所述柠檬烯与所述柠檬油的重量比为1:0.6。
所述橙皮提取物提取方法:
称取20.0g橙皮干燥并进行粉碎后,加入质量浓度为50%~60%的乙醇,浸泡2~3h后使用微波加热提取2~3次,过滤,滤液经减压浓缩至无乙醇,即得。
所述含有中药活性物质和茶树精油液体口腔用组合物的制备方法和所述改性氯化钙的制备方法同实施例1。
实施例7
所述含有中药活性物质和茶树精油液体口腔用组合物,按重量份计算,包括:鼠曲草提取物0.7份,车前草提取物0.5份,短柄野芝麻提取物1.0份,五倍子、金银花及橙皮混合提取物2.3份,紫罗兰提取物0.02份,薄荷提取物0.35份、甜叶菊提取物0.12份、三色堇提取物0.003份、藏茴香提取物0.007份,所述木糖醇3.1份,柠檬酸0.15份、蜂胶0.05份、柠檬油0.003份和改性氯化钙0.06份,薄荷醇0.002份,茶树精油0.003份,水92份;所述五倍子与金银花、橙皮的重量比为1:0.3:0.2。
所述含有中药活性物质和茶树精油液体口腔用组合物的制备方法和所述改性氯化钙的制备方法同实施例1。
实施例8
所述含有中药活性物质和茶树精油液体口腔用组合物,按重量份计算,包括:绿茶提取物1.6份,鼠曲草提取物0.7份,车前草提取物0.5份,短柄野芝麻提取物1.0份,茶树根提取物0.6份,五倍子、金银花及橙皮混合提取物2.3份,紫罗兰提取物0.02份,薄荷提取物0.35份、甜叶菊提取物0.12份、三色堇提取物0.005份、藏茴香提取物0.007份,所述木糖醇3.1份,柠檬酸和柠檬酸钠0.15份、蜂胶0.05份、柠檬烯和柠檬油0.003份和改性氯化钙0.01份,薄荷醇0.002份,茶树精油0.003份,水92份;所述五倍子与金银花、橙皮的重量比为1:0.3:0.2;所述柠檬酸与所述柠檬酸钠的重量比为1:0.8;所述柠檬烯与所述柠檬油的重量比为1:0.6。
所述含有中药活性物质和茶树精油液体口腔用组合物的制备方法和所述改性氯化钙的制备方法同实施例1。
实施例9
所述含有中药活性物质和茶树精油液体口腔用组合物,按重量份计算,包括:绿茶提取物1.6份,鼠曲草提取物0.7份,车前草提取物0.5份,短柄野芝麻提取物1.0份,茶树根提取物0.6份,五倍子、金银花及橙皮混合提取物2.3份,紫罗兰提取物0.02份,薄荷提取物0.35份、甜叶菊提取物0.12份、三色堇提取物0.005份、藏茴香提取物0.007份,所述木糖醇3.1份,柠檬酸和柠檬酸钠0.15份、蜂胶0.05份、柠檬烯和柠檬油0.003份和改性氯化钙0.15份,薄荷醇0.002份,茶树精油0.003份,水92份;所述五倍子与金银花、橙皮的重量比为1:0.3:0.2;所述柠檬酸与所述柠檬酸钠的重量比为1:0.8;所述柠檬烯与所述柠檬油的重量比为1:0.6。
所述含有中药活性物质和茶树精油液体口腔用组合物的制备方法和所述改性氯化钙的制备方法同实施例1。
对比例1
所述含有中药活性物质和茶树精油液体口腔用组合物,按重量份计算,包括:绿茶提取物1.6份,鼠曲草提取物0.7份,车前草提取物0.5份,短柄野芝麻提取物1.0份,茶树根提取物0.6份,五倍子、金银花及橙皮混合提取物2.3份,紫罗兰提取物0.02份,薄荷提取物0.35份、甜叶菊提取物0.12份、三色堇提取物0.005份、藏茴香提取物0.007份,所述木糖醇3.1份,柠檬酸和柠檬酸钠0.15份、蜂胶0.05份、柠檬烯和柠檬油0.003份和改性氯化钙0.06份,薄荷醇0.002份,茶树精油0.003份,水92份;所述五倍子与金银花、橙皮的重量比为1:0.3:0.2;所述柠檬酸与所述柠檬酸钠的重量比为1:0.8;所述柠檬烯与所述柠檬油的重量比为1:0.6;所述改性氯化钙为丙烯酸包覆氯化钙。
所述改性氯化钙的制备方法包括如下步骤:
将氯化钙加入料桶温度为50℃高速混合机中,按重量比加入丙烯酸,搅拌1h后,出料,把高速混合机料桶温度升至120℃后,将上述物料倒回高速混合机中,高速搅拌1h后出料,得到丙烯酸包覆氯化钙;所述丙烯酸与所述氯化钙的重量比为1:13。
所述含有中药活性物质和茶树精油液体口腔用组合物的制备方法同实施例1。
对比例2
所述含有中药活性物质和茶树精油液体口腔用组合物,按重量份计算,包括:绿茶提取物1.6份,鼠曲草提取物0.7份,车前草提取物0.5份,短柄野芝麻提取物1.0份,茶树根提取物0.6份,五倍子、金银花及橙皮混合提取物2.3份,紫罗兰提取物0.02份,薄荷提取物0.35份、甜叶菊提取物0.12份、三色堇提取物0.005份、藏茴香提取物0.007份,所述木糖醇3.1份,柠檬酸和柠檬酸钠0.15份、蜂胶0.05份、柠檬烯和柠檬油0.003份和氯化钙0.06份,薄荷醇0.002份,茶树精油0.003份,水92份;所述五倍子与金银花、橙皮的重量比为1:0.3:0.2;所述柠檬酸与所述柠檬酸钠的重量比为1:0.8;所述柠檬烯与所述柠檬油的重量比为1:0.6。
所述含有中药活性物质和茶树精油液体口腔用组合物的制备方法同实施例1。
对比例3
所述含有中药活性物质和茶树精油液体口腔用组合物,按重量份计算,包括:车前草提取物0.5份,橙皮提取物2.3份,紫罗兰提取物0.02份,甜叶菊提取物0.12份、三色堇提取物0.005份、藏茴香提取物0.007份,所述木糖醇3.1份,柠檬酸和柠檬酸钠0.15份、蜂胶0.05份、柠檬烯和柠檬油0.003份和改性氯化钙0.06份,薄荷醇0.002份,茶树精油0.003份,水92份;所述柠檬酸与所述柠檬酸钠的重量比为1:0.8;所述柠檬烯与所述柠檬油的重量比为1:0.6。
所述含有中药活性物质和茶树精油液体口腔用组合物的制备方法和所述改性氯化钙的制备方法同实施例1。
性能测试:
1、外观稳定性的评价:
将450ml样品液体口腔用组合物填充到满刻度450ml的PET容器,目测判定在50℃的恒温槽中保存3个月后或在-10℃的恒温槽中保存3个月后的稳定性。外观稳定性(50℃、3个月)的评价基准:
好:制剂的色调没有变化;
一般:制剂的色调仅有一点点褪色但还是没问题的水平;
差:制剂的色调有褪色。
外观稳定性(-10℃、3个月)的评价基准:
好:没有变化;
一般:可看到非常小的分离,但还是没问题的水平;
差:有分离、制剂的色调也有褪色。
2、口感
受试者10人,***10ml样品(液体口腔用组合物)漱口30秒后,评价使用制剂漱口10分钟后清凉感的持续性、滞留真实感和无粘滞感,按照以下基准判定10人的平均分。
(1)清凉感的持续性
5分:强烈感觉到清凉感的持续性
4分:较强地感觉到清凉感的持续性
3分:感觉到清凉感的持续性
2分:基本感觉不到清凉感的持续性
1分:感觉不到清凉感的持续性;
(2)滞留真实感
4分:强烈感觉到漱口剂在口中的残留感
3分:感觉到漱口剂在口中的残留感
2分:基本感觉不到漱口剂在口中的残留感
1分:感觉不到漱口剂在口中的残留感;
(3)粘滞感
4分:感觉不到粘滞感
3分:基本感觉不到粘滞感
2分:感觉到粘滞感
1分:强烈感觉到粘滞感。
3、抑菌活性
在无菌操作台内将实施例和对比例中液体口腔用组合物,还有作为对照组的生理食盐水皆各取9ml,并分别添加入无菌玻璃试管中。接着,在每一无菌玻璃试管中再加入1ml大肠杆菌的菌液(光度值(O.D)为0.1,菌落数为106CFU/ml)与其混匀进行光密度法量测。又同时由每一无菌玻璃试管取出菌液且将稀释的菌液涂抹于固态培养基中进行涂盘法量测。之后将每一无菌玻璃试管及每一固态培养基置于37℃的恒温培养箱中培养8小时,再测定每一无菌玻璃试管培养后的吸光值与每一涂盘培养后的菌落数。
涂盘法的抑菌活性是对照组涂盘培养后的菌落数与实验组涂盘培养后的菌落数之差除以对照组涂盘培养后的菌落数。分别对大肠杆菌、金黄色葡萄球菌及绿脓杆菌进行测试,得到抑菌活性的数据。
表1性能测试结果
从上述测试结果中可以看出,与丙烯酸包覆氯化钙,氯化钙,无绿茶提取物、鼠曲草提取物、短柄野芝麻提取物、茶树根提取物、五倍子提取物、金银花提取物、薄荷提取物的对比例相比,本发明不仅口感极佳,缓解口腔不适症状,保持良好的微生态,并且还具有消炎止痛的功效。
前述的实例仅是说明性的,用于解释本发明所述方法的一些特征。所附的权利要求旨在要求可以设想的尽可能广的范围,且本文所呈现的实施例仅是根据所有可能的实施例的组合的选择的实施方式的说明。因此,申请人的用意是所附的权利要求不被说明本发明的特征的示例的选择限制。在权利要求中所用的一些数值范围也包括了在其之内的子范围,这些范围中的变化也应在可能的情况下解释为被所附的权利要求覆盖。
Claims (10)
1.一种含有中药活性物质和茶树精油液体口腔用组合物,其特征在于,按重量份计算,包括:
其中,所述中药提取物包括绿茶提取物,鼠曲草提取物,车前草提取物,短柄野芝麻提取物,茶树根提取物,五倍子、金银花及橙皮混合提取物,紫罗兰提取物;所述添加剂包括润湿剂、pH调节剂、防腐剂、香精和絮凝剂。
2.根据权利要求1所述含有中药活性物质和茶树精油液体口腔用组合物,其特征在于,所述中药提取物还包括薄荷提取物、甜叶菊提取物、三色堇提取物、藏茴香提取物。
3.根据权利要求1所述含有中药活性物质和茶树精油液体口腔用组合物,其特征在于,
所述润湿剂包括山梨糖醇、木糖醇、麦芽糖醇、乳糖醇、乙二醇中一种或多种。
4.根据权利要求1所述含有中药活性物质和茶树精油液体口腔用组合物,其特征在于,所述pH调节剂包括邻苯二甲酸、磷酸、柠檬酸、琥珀酸、乙酸、富马酸、苹果酸、碳酸、磷酸二氢钠、磷酸一氢钠、柠檬酸钠中一种或多种。
5.根据权利要求1所述含有中药活性物质和茶树精油液体口腔用组合物,其特征在于,所述防腐剂包括苯甲酸钠、对羟基苯甲酸甲酯、对羟基苯甲酸乙酯、对羟基苯甲酸丙酯、对羟基苯甲酸丁酯等对羟基苯甲酸酯、甘氨酸烷基二氨基乙酯盐酸盐、山梨酸钾、蜂胶中一种或多种。
6.根据权利要求1所述含有中药活性物质和茶树精油液体口腔用组合物,其特征在于,所述香精包括留兰香油、桉树油、冬青油、丁香油、百里香油、鼠尾草油、小豆蔻油、迷迭香油、马郁兰油、柠檬油、肉豆蔻油、薰衣草油、天神草油、L-香芹酮、1,8-桉树脑、水杨酸甲酯、丁香酚、百里酚、芳樟醇、柠檬烯、薄荷酮、乙酸薄荷酯、柠檬醛、樟脑、冰片、蒎烯、千日菊素中一种或多种。
7.根据权利要求1所述含有中药活性物质和茶树精油液体口腔用组合物,其特征在于,所述絮凝剂为改性氯化钙,所述改性氯化钙为丙烯酸包覆氯化钙后接枝壳聚糖。
8.根据权利要求7所述含有中药活性物质和茶树精油液体口腔用组合物,其特征在于,所述改性氯化钙的接枝率为1~5%。
9.根据权利要求8所述含有中药活性物质和茶树精油液体口腔用组合物,其特征在于,所述改性氯化钙的接枝率为1~3%。
10.根据权利要求1~9所述含有中药活性物质和茶树精油液体口腔用组合物的制备方法,其特征在于,包括以下步骤:
(1)按重量份加入中药提取物,薄荷醇,茶树精油和水,搅拌,使所述中药提取物溶解于水中;
(2)按重量份加入添加剂,充分搅拌,过滤,取滤液,经杀菌处理,得到所述含有中药活性物质和茶树精油液体口腔用组合物。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610943361.9A CN106562921B (zh) | 2016-11-02 | 2016-11-02 | 一种含有中药活性物质和茶树精油液体口腔用组合物 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610943361.9A CN106562921B (zh) | 2016-11-02 | 2016-11-02 | 一种含有中药活性物质和茶树精油液体口腔用组合物 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN106562921A true CN106562921A (zh) | 2017-04-19 |
CN106562921B CN106562921B (zh) | 2020-11-24 |
Family
ID=58536386
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201610943361.9A Expired - Fee Related CN106562921B (zh) | 2016-11-02 | 2016-11-02 | 一种含有中药活性物质和茶树精油液体口腔用组合物 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN106562921B (zh) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108272675A (zh) * | 2018-03-18 | 2018-07-13 | 太极娃生物科技有限公司 | 儿童口腔护理组合物及其在儿童防龋齿中的应用 |
CN108852939A (zh) * | 2018-08-23 | 2018-11-23 | 无限极(中国)有限公司 | 一种保湿组合物及其制备的化妆品 |
US10588924B1 (en) * | 2017-12-22 | 2020-03-17 | Aesthetics Biomedical, Inc. | Biologic preserving composition and methods of use |
US10933096B2 (en) * | 2017-12-22 | 2021-03-02 | Aesthetics Biomedical, Inc. | Biologic preserving composition and methods of use |
CN115770205A (zh) * | 2021-09-04 | 2023-03-10 | 武汉左点科技有限公司 | 一种口腔清洗液及其制备方法和应用 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101007077A (zh) * | 2006-01-25 | 2007-08-01 | 杭州北斗生物技术有限公司 | 一种含有天然植物提取物的口腔用组合物 |
CN101642420A (zh) * | 2009-06-18 | 2010-02-10 | 杭州六易科技有限公司 | 一种口腔清新剂的制作方法 |
CN104887581A (zh) * | 2015-06-11 | 2015-09-09 | 云南天美天康生物科技有限公司 | 一种口腔护理组合物及其制备方法 |
-
2016
- 2016-11-02 CN CN201610943361.9A patent/CN106562921B/zh not_active Expired - Fee Related
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101007077A (zh) * | 2006-01-25 | 2007-08-01 | 杭州北斗生物技术有限公司 | 一种含有天然植物提取物的口腔用组合物 |
CN101642420A (zh) * | 2009-06-18 | 2010-02-10 | 杭州六易科技有限公司 | 一种口腔清新剂的制作方法 |
CN104887581A (zh) * | 2015-06-11 | 2015-09-09 | 云南天美天康生物科技有限公司 | 一种口腔护理组合物及其制备方法 |
Non-Patent Citations (2)
Title |
---|
侯海云: "《表面活性剂物理化学基础》", 31 August 2014, 西安:西安交通大学出版社 * |
方亮: "《药用高分子材料学》", 31 August 2015, 北京:中国医药科技出版社 * |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10588924B1 (en) * | 2017-12-22 | 2020-03-17 | Aesthetics Biomedical, Inc. | Biologic preserving composition and methods of use |
US10933096B2 (en) * | 2017-12-22 | 2021-03-02 | Aesthetics Biomedical, Inc. | Biologic preserving composition and methods of use |
US11446330B2 (en) * | 2017-12-22 | 2022-09-20 | Aesthetics Biomedical, Inc. | Biologic preserving composition and methods of use |
CN108272675A (zh) * | 2018-03-18 | 2018-07-13 | 太极娃生物科技有限公司 | 儿童口腔护理组合物及其在儿童防龋齿中的应用 |
CN108852939A (zh) * | 2018-08-23 | 2018-11-23 | 无限极(中国)有限公司 | 一种保湿组合物及其制备的化妆品 |
CN115770205A (zh) * | 2021-09-04 | 2023-03-10 | 武汉左点科技有限公司 | 一种口腔清洗液及其制备方法和应用 |
Also Published As
Publication number | Publication date |
---|---|
CN106562921B (zh) | 2020-11-24 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
KR101176590B1 (ko) | 숙취 해소용 한약 조성물 및 이를 함유하는 음료 | |
Panda | Handbook on medicinal herbs with uses: medicinal plant farming, most profitable medicinal plants in India, medicinal plants farming in India, plants used in herbalism, medicinal herbs you can grow, medicinal herbs and their uses, medicinal herbs, herbal & medicinal plants, growing medicinal herb, most profitable medicinal herbs growing with small investment, herbal medicine herbs | |
Guarino et al. | Ethnobotanical study of the Sannio area, Campania, southern Italy | |
CN106562921A (zh) | 一种含有中药活性物质和茶树精油液体口腔用组合物 | |
KR20140049673A (ko) | 함초, 민들레, 생강나무 등 125가지의 원재료를 생물의 물성에 따라 CO2(또는 N2) Carrier Gas를 이용하여 추출농축, 설탕에 절임에 의한 천연발효 효소법에 의해 추출 및 Microwave와 Filter를 이용하여 추출한 추출물들을 혼합발효숙성하여 제조한 조성물과 그 조성방법 | |
Hutchens | A Handbook of Native American Herbs: The Pocket Guide to 125 Medicinal Plants and Their Uses | |
CN102940595A (zh) | 一种具有抗菌消炎脱臭的漱口液及其制备方法和用途 | |
CN105106894A (zh) | 一种治疗红剑鱼白头白嘴病的中草药制剂及其制备方法 | |
KR100867514B1 (ko) | 지초 비누의 제조방법 | |
CN101181208B (zh) | 一种含天然抗菌素的漱口液及其制备方法 | |
JPH0616530A (ja) | 化粧料 | |
CN106491415A (zh) | 一种祛痘美白遮瑕霜及其制备方法 | |
CN107233599B (zh) | 可快速去除空气内金属污染物的空气净化剂 | |
CN105056159A (zh) | 一种治疗猪寄生虫病的药物及其制备方法 | |
KR100747415B1 (ko) | 여성 젖몸살 완화 효과가 있는 추출혼합물을 함유하는화장료 조성물 | |
CN107137336A (zh) | 一种祛痘中药面膜及其制备方法 | |
CN107320758A (zh) | 一种高效除去畜禽养殖环境细菌的空气净化剂 | |
KR100903827B1 (ko) | 수제 한방 비누 및 그 제조방법 | |
CN110368466A (zh) | 一种私护抑菌凝胶及其制备方法 | |
CN105613612A (zh) | 一种用于重症监护室消毒的药剂及制备方法 | |
CN109248258A (zh) | 一种口腔手术后护理用中草药含漱液 | |
CN108935525A (zh) | 一种适用于奶牛场的环保消毒剂 | |
CN106983691A (zh) | 一种含莲多酚的抗氧化收缩毛孔睡眠面膜及其制备方法 | |
CN105920334A (zh) | 菊花痤疮膏 | |
CN104873824A (zh) | 一种治疗百日咳的中药剂及制法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
GR01 | Patent grant | ||
GR01 | Patent grant | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20201124 |