CN106511559A - Medicine for treating damp-heat diarrhea and preparation method of medicine - Google Patents
Medicine for treating damp-heat diarrhea and preparation method of medicine Download PDFInfo
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Abstract
The invention discloses a medicine for treating damp-heat diarrhea. The medicine comprises the following traditional Chinese medicines in parts by weight: 10-30 parts of breynia fruticosa, 10-25 parts of humulus scandens, 10-30 parts of radix puerariae, 5-20 parts of rhizoma cimicifugae, 10-15 parts of semen coicis, 10-15 parts of cortex magnoliae officinalis, 6-15 parts of rhizoma atractylodis macrocephalae, 3-9 parts of radix codonopsis, 3-6 parts of pericarpium citri reticulatae and 1-5 parts of licorice. The invention further discloses a preparation method of medicine capsules. The medicine adopts a rigorous prescription, is concentrated in efficacy due to a few medicines adopted, has good curative effect on damp-heat diarrhea and can significantly relieve chronic diarrhea caused by damp, heat and weakness of the spleen and the stomach, in particular to symptoms such as diarrhea urgency, non-smooth diarrhea, yellow brown stool, scorch of anus, fever with restlessness, thirst, abdominal pain, scanty dark urine, slimy yellow tongue fur and the like of chronic diarrhea patients with symptoms of damp-heat diarrhea particularly.
Description
Technical field
The present invention relates to biomedicine field, and in particular to a kind of to treat medicine of diarrhea due to damp-heat and preparation method thereof.
Background technology
Diarrhoea refer to defecation frequency significantly more than the frequency being accustomed on ordinary days, excrement matter is thin, daily Fecal wastes more than 200g, or
Containing food or pus and blood is not digested, chronic diarrhea refers to the recurrent of diarrhoea of the course of disease more than two months or intermission in 2-4 is all
Diarrhoea.Chronic diarrhea is clinically common sympton.Show as times of defecation and increase just dilute, or even the viscous jelly of band, pus and blood, continue two
More than month.The characteristics of small intestinal pathological changes cause diarrhoea is abdominal discomfort, more positioned at umbilicuss week, and in after the meal or just front aggravation, without pain in the abdomen
After weigh, stool amount is more, and color is shallow, and number of times is the amount doesn't matter；The characteristics of colonic pathological change causes diarrhoea is abdominal discomfort, positioned at abdominal part both sides
Or lower abdomen, Chang Yu is alleviated after an action of the bowels or is mitigated, more than defecation frequency and anxious, and feces amount is few, often contains blood and mucus；Rectal lesion causes
Person is often accompanied by tenesmus.
Clinically case is of common occurrence for chronic diarrhea, and middle-aged and elderly people is in the majority, and the touching speed that is difficult to of the course of disease heals, because of diet not often
Section, daily life are not normal, work excessively recurrence aggravation, with the passing of time cause body increasingly weak, and muscle power, spirit are not propped up, and affect normal work
And life.The chronic diarrhea cause of disease is various, and pathological change is complicated, and the traditional Chinese medical science thinks that spleen asthenia and dampness retention is the key of morbidity：The spleen has the function to transport and transform nutrients rises
Clearly, deficiency-weakness of spleen-QI, clear QI failing to ascend, metaplasia endogenous dampness, clear QI being mixed up with turbid QI, mix and under, then into diarrhoea, this is《Interior Jing》, remembered " clearing heat in QI system
Under, then give birth to lientery " meaning；Benefit that diarrhoea is with the passing of time insufficiency of the spleen very, is stopped in damp, with the passing of time changes heat, and damp-heat stagnating in the spleen causes transformation failure of spleen, rises
Drop imbalance, and there is diarrhoea, this is that the touching difficult pathogenesis more of diarrhoea is located.Present invention is particularly directed to Chronic Diarrhea Patients, especially
It is that chronic diarrhea lays particular stress on damp and hot patient, works out a kind of safely and effectively Chinese medicine composition, at present, there is not yet relevant report.
(1) Fruticose Breyniae Leaf and Twig, is the dry twig leaf of euphorbia plant Fruticose Breyniae Leaf and Twig Breynia fruticosa (L.) Hook.f..
【Nature and flavor and return through】Mildly bitter flavor；It is cool in nature.Return large intestine；Liver Channel.【Indication】Clearing heat and expelling damp, promoting blood circulation and detoxication.Main stomachache is vomited and diarrhoea；It is wet
Rash；Herpes zoster；Dermatitis；Dermatitis rhus；Rheumatic arthralgia；Puerperal galactostasiss；Pudendal pruritus.
(2) grass, moraceae plants grass Humulus scandens (Lour.) Merr.'s is dried herb.【Nature and flavor with return
Jing】It is sweet；It is bitter；It is cold in nature.Return lung；Kidney channel.【Indication】Heat-clearing and toxic substances removing；Inducing diuresis for treating stranguria syndrome.Main cough due to lung-heat；Lung abscess；Deficiency-heat excessive thirst；
Pyretic stranguria；Edema；Dysuria；Damp-heat dysentery；Pathopyretic ulcer；Skin pruritus.
(3) Radix Puerariae, is legume pueraria lobata Pueraria lobata (Willd.) Ohwi or Radix Puerariae rattan Pueraria
The dry root of thomsonii Benth..【Nature and flavor and return through】It is sweet, pungent, it is cool.Returns spleen, stomach.【Indication】Expelling pathogenic factors from muscles for reducing heat, it is raw
Tianjin, rash, Shengyang Zhixie.It is for fever caused by exogenous pathogens headache, stiff nape and back, thirsty, to quench one's thirst, measles without adequate eruption, hematodiarrhoea are had loose bowels；High blood
Pressure neck pain.
(4) Rhizoma Cimicifugae, is ranunculaceae plant C.heracleifolia Cimicifuga heracleifolia Kom., Cimicifuga Dahurica
The dry rhizome of Cimicifuga dahurica (Turcz.) Maxim. or Rhizoma Cimicifugae Cimicifuga foetida L..【Nature and flavor
With return through】Pungent, micro-sweet, is slightly cold.Return lung, spleen, stomach, large intestine channel.【Indication】Rash is delivered, heat-clearing and toxic substances removing rises and lifts yang-energy.With
In headache due to pathogenic wind-heat, toothache, aphtha, laryngopharynx swelling and pain, measles without adequate eruption, YANG toxin syndrome send out speckle；Proctoptosis, uterine prolapse.
(5) Semen Coiciss, are grass Semen Coiciss Coix lacryma-jobi L.var.ma-yuen (Roman.)
The dry mature kernal of Stapf.【Nature and flavor and return through】It is sweet, light, it is cool.Returns spleen, stomach, lung meridian.【Function with cure mainly】Promoting diuresis to eliminate damp pathogen, is good for
Spleen antidiarrheal, eliminating impediment, evacuation of pus, detoxicating and resolving stagnation of pathogens.For edema, tinea pedis, dysuria, diarrhea due to hypofunction of the spleen, arthralgia chiefly caused by damp pathogen contracture, lung abscess, acute appendicitis,
Wart, cancerous protuberance.
(6) Cortex Magnoliae Officinalis, is Magnoliacea plant Cortex Magnoliae Officinalis Magnolia officinalis Rehd.et Wils. or magnolia officinalis rehd.et wils.var.biloba rehd.et wils.
Magnolia offinalis Rehd.et Wils.var.biloba Rehd.et Wils.'s is dried dried bark, root bark and branch
Skin.【Nature and flavor and return through】It is bitter, pungent, temperature.Returns spleen, stomach, lung, large intestine channel.【Function with cure mainly】Eliminating dampness dissolving phlegm, lower gas removes full.For
In humidity hysteresis wound, gastral cavity ruffian is vomited and diarrhoea, stagnation of QI due to dyspepsia, abdominal distention constipation, phlegm and retained fluid is breathed with cough.
(7) Rhizoma Atractylodis Macrocephalae, is the dry rhizome of feverfew Rhizoma Atractylodis Macrocephalae Atractylodes macrocephala Koidz..【Property
Taste and return through】It is bitter, sweet, temperature.Returns spleen, stomach.【Indication】Invigorating the spleen and benefiting QI, eliminate dampness and have diuretic effect, hidroschesis are antiabortive.For insufficiency of the spleen food
It is few, abdominal distention diarrhea, phlegm retention anti-dazzle nervous, edema, spontaneous perspiration, frequent fetal movement.
(8) Radix Codonopsis, is Campanulaceae Radix Codonopsis Codonopsis pilosula (Franch.) Nannf., codonopsis pilosula var. modesta
(RADIX CODONOPSIS PILOSULAE from Northwest of China) Codonopsis pilosula Nannf.var.modesta (Nannf.) L.T.Shen or radix codonpsis tangshen
The dry root of Codonopsis tangshen Oliv..【Nature and flavor and return through】It is sweet, put down.Returns spleen, lung meridian.【Indication】Invigorating middle warmer
QI invigorating, strengthening spleen and tonifying lung.For deficiency of the spleen and lung, shortness of breath palpitations, anorexia and loose stool, virtual asthma cough, Heat Diabetes.
(9) Pericarpium Citri Reticulatae, is the drying and ripening of rutaceae orange Citrus reticulata Blanco and its variety
Peel.【Nature and flavor and return through】It is bitter, pungent, temperature.Return lung, spleen channel.【Indication】Regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.For fullness in the epigastrium and chest,
Lack of appetite and vomiting, cough with copious phlegm.
(10) Radix Glycyrrhizae, is glycyrrhizic legume Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat.
Glycyrrhiza inflata Bat.'s or Glycyrrhiza glabra L. Glycyrrhiza glabra L. is dried root and rhizome.【Nature and flavor with
Return through】It is sweet, put down.GUIXIN, lung, spleen, stomach.【Indication】Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain reconcile
All medicines.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, four limbs contraction, carbuncle sore tumefacting virus, alleviate
It is drug toxicity, strong.
The disclosure of background above technology contents is only used for inventive concept and the technical scheme for aiding in understanding the present invention, and which is not
The prior art of present patent application is necessarily belonged to, shows the applying date of the above in present patent application there is no tangible proof
In the case of disclosed, above-mentioned background technology should not be taken to evaluate the novelty and creativeness of the application.
The content of the invention
It is an object of the invention to provide a kind of treat medicine of diarrhea due to damp-heat and preparation method thereof, the medicine be inventor from
Suitable raw material is selected in the practical application of traditional herbal medicine, under the guidance of Chinese medical theory, is formed by reasonable preparation, is had
Heat-clearing and toxic substances removing, Shengyang Zhixie effect, have no toxic side effect, moreover it is possible to improve immunity of organisms, reach treatment diarrhea due to damp-heat relevant disease,
The purpose improved the quality of living.
The technical solution adopted in the present invention is as follows：
A kind of medicine for treating diarrhea due to damp-heat, raw material are made up of the Chinese medicine of following weight portion：Fruticose Breyniae Leaf and Twig's 10-30 parts, grass
10-25 parts, Radix Puerariae 10-30 parts, Rhizoma Cimicifugae 5-20 parts, Rhizoma Atractylodis Macrocephalae 6-15 parts, Radix Codonopsis 3-9 parts, Pericarpium Citri Reticulatae 3-6 parts, Radix Glycyrrhizae 1-5 parts.
The medicine of above-described treatment diarrhea due to damp-heat, raw material are preferably made up of the Chinese medicine of following weight portion：Fruticose Breyniae Leaf and Twig 20
Part, 20 parts of grass, 20 parts of Radix Puerariae, 15 parts of Rhizoma Cimicifugae, 10 parts of the Rhizoma Atractylodis Macrocephalae, 6 parts of Radix Codonopsis, 5 parts of Pericarpium Citri Reticulatae, 3 parts of Radix Glycyrrhizae.
The medicine of above-described treatment diarrhea due to damp-heat, the medicine preparation is into any preparation for pharmaceutically allowing；It is preferred that
Oral formulations are prepared into, such as：Capsule, tablet, powder, granule, pill or oral liquid etc..
The medicine of above-described treatment diarrhea due to damp-heat, the medicine are most preferably preferably prepared to capsule.
More than one treatment diarrhea due to damp-heat medicines make the preparation method of capsule, comprise the following steps：
S1：Raw material is weighed respectively by following weight portion：Fruticose Breyniae Leaf and Twig's 10-30 parts, grass 10-25 parts, Radix Puerariae 10-30 parts, liter
Numb 5-20 parts, Rhizoma Atractylodis Macrocephalae 6-15 parts, Radix Codonopsis 3-9 parts, Pericarpium Citri Reticulatae 3-6 parts, Radix Glycyrrhizae 1-5 parts；
S2：By load weighted raw material, plus 6-10 times is measured water, is decocted and is extracted 1-3 time, and each 1-3 hours, filtration merge and filter
Liquid, clear paste of the relative density for 1.15-1.25 when being concentrated into 60 DEG C；
S3：Qinghuo reagent, adds 95% ethanol to be 50-60% to clear paste alcohol content, stands 24～48h, filter at 5～10 DEG C
Cross, thick paste of the relative density for 1.20-1.35 when filtrate is concentrated into 60 DEG C；
S4：Filler, binding agent being added in thick paste, being mixed, granulation is dried, obtains dry particl；
S5：Lubricant is added in dry particl, is mixed, loaded capsule, obtain final product.
The above filler is preferably one or more combinations in starch, Microcrystalline Cellulose, Lactose and dextrin.
The above binding agent is preferably starch slurry, sodium carboxymethyl cellulose, hydroxypropyl cellulose, methylcellulose, second
One kind or one in base cellulose, hydroxypropyl methyl cellulose, sucrose solution, the aqueous solution of polyvinylpyrrolidone or alcoholic solution
Plant combination of the above.
The above lubricant is preferably one or more combinations in magnesium stearate, Pulvis Talci and silicon dioxide.
The medicine of the above treatment diarrhea due to damp-heat, the medicine is in the medicine for preferably preparing treatment diarrhea due to damp-heat disease
Purposes.
The present invention treatment diarrhea due to damp-heat medicine be on the basis of Chinese medicine traditional theory, with reference to medication experience among the people,
It is formulated with modern scientific theory.In side, Fruticose Breyniae Leaf and Twig has clearing heat and expelling damp, and the work(of promoting blood circulation and detoxication is also monarch drug；Grass tool
There is the work(of heat-clearing and toxic substances removing, inducing diuresis for treating stranguria syndrome, be ministerial drug；Radix Puerariae have expelling pathogenic factors from muscles for reducing heat, promote the production of body fluid, rash, Shengyang Zhixie the effect of, be minister
Medicine；Rhizoma Cimicifugae tool delivers rash, and heat-clearing and toxic substances removing rises the work(for lifting yang-energy, the heat-clearing and toxic substances removing and yang invigorating of energy principal drug assistance, therefore is ministerial drug Semen Coiciss
Core, Cortex Magnoliae Officinalis diuretic, dampness, are ministerial drug；Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae have the work(of air making-up and spleen enlivening, are ministerial drug；Pericarpium Citri Reticulatae has regulating qi-flowing for strengthening spleen, dry
The work(of humidifying expectorant, is adjuvant drug；Radix Glycyrrhizae has functions that invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription,
For making medicine；All medicines share plays heat-clearing and toxic substances removing, yang invigorating altogether, and dampness strengthens the spleen and stomach, and pathogenic fire reducing promotes the production of body fluid, the work(of diuresis.Prescription of the present invention is tight
Sincerely, the few power of medicine specially, to chronic diarrhea caused by diarrhea due to damp-heat, weakness of the spleen and stomach, particularly lays particular stress on the chronic diarrhea of diarrhea due to damp-heat symptom
Patient has good curative effect.
Specific embodiment
With reference to specific embodiment, the invention will be further described, but do not limit the scope of the invention and apply
Scope：
First, treat the preparation method that diarrhea due to damp-heat medicine makes capsule
1. EXPERIMENTAL DESIGN：
This test is prepared into capsule respectively with 4 embodiments, and design parameter refers to table 1.
1 capsule embodiment preparation parameter table of table
2. operating procedure：
S1：As listed by table 1, parameter weighs weight respectively and weighs raw material respectively：Fruticose Breyniae Leaf and Twig, grass, Radix Puerariae, Rhizoma Cimicifugae, Semen Coiciss
Core, Cortex Magnoliae Officinalis, the Rhizoma Atractylodis Macrocephalae, Radix Codonopsis, Pericarpium Citri Reticulatae, Radix Glycyrrhizae；
S2：By load weighted raw material, the parameter as listed by table 1, add water, decoct and extract, filtration, merging filtrate are concentrated into 60
DEG C when relative density for 1.15-1.25 clear paste；
S3：Qinghuo reagent, the parameter as listed by table 1 add 95% ethanol to clear paste alcohol content to be 50-60%, quiet at 5～10 DEG C
24～48h is put, is filtered, thick paste of the relative density for 1.20-1.35 when filtrate is concentrated into 60 DEG C；
S4：The parameter as listed by table 1, adds filler, binding agent in thick paste, mixes, and granulation is dried, obtains dry particl；
S5：The lubricant as listed by table 1 is added in dry particl, is mixed, loaded capsule, obtain final product.
2nd, clinical practice
1. case selection standard
All cases meet 2002《New Chinese medicine guideline of clinical investigations》Diagnostic criteria.
(1) clinical cardinal symptom is：Times of defecation increases, 3 times/more than d, with the change of stool amount and character, symptom
Continue more than half a day；, stool yellow skin brown not well with having loose bowels urgently or rushing down, burning sensation of the anus, dysphoria with smothery sensation, thirsty, stomachache, oliguria
The phenomenons such as red, yellowish fur.
(2) age 10-70 year.
2. standard is discharged：
(1) it is dialectical indefinite or have and excessive simultaneous hold disease person under the arm.
(2) gestation or newborn phase women.
(3) severe primary such as cardiovascular, liver, kidney and hemopoietic system disease and psychotic are associated with.
(4) not by regulation drug administration person.
3. therapeutic scheme
(1) embodiment group：By above-mentioned 3 sample of embodiment for preparing, for clinical trial.Orally, one time 4, one day 3
It is secondary.The course for the treatment of：Medication 3 days.
(2) matched group：Trimebutine maleate table (commercially available).Orally, a 100mg, 3 times a day.The course for the treatment of：Medication 3 days.
3. efficacy assessment standard
According to case selection standard, reference《Disease of tcm diagnoses and treatment standard》And《New Chinese medicine clinical research is instructed former
Then》, curative effect is divided into into recovery from illness, effective, invalid.
(1) fully recover：Clinical symptom disappearance within treatment 3 days, that 2 times a day is following for times of defecation, and stool shape recovers normal.
(2) effectively：Within treating 3 days, clinical symptoms take a turn for the better, and times of defecation is slightly more, 34 times on the 1st, basic to shape.
(3) it is invalid：Within treating 3 days, clinical symptoms, stool shape and number of times without improvement or deteriorate.
4. result of the test：For treating and observing 75 outpatients.By above-mentioned 3 sample of embodiment for preparing and Malaysia
Sour trimebutine piece (commercially available), is respectively used to patient：Treatment group：It is 45 (man 22, female 23,38.1 years old mean age), right
According to group 30 (man 13, female 17,41.8 years old mean age), the results detailed in Table 2.
2 clinical trial result table of table
As a result show：Treated using the embodiment of the present invention 3, treatment 3 days within cure rate be 69%, effective percentage up to 96%,
General effect is slightly better than matched group, and no untoward reaction occurs, let out using safely, effectively, being obviously improved Chronic Diarrhea Patients
Rush down urgent or rush down and the phenomenon such as not well, brown stool yellow skin, burning sensation of the anus, dysphoria with smothery sensation, thirsty, stomachache, oliguria with reddish urine, yellowish fur,
Heat-clearing and toxic substances removing, yang invigorating, dampness strengthen the spleen and stomach, and pathogenic fire reducing promotes the production of body fluid, the work(of diuresis.Prescription of the present invention is rigorous, and the few power of medicine is special, to damp and hot
Have loose bowels, chronic diarrhea caused by weakness of the spleen and stomach, the Chronic Diarrhea Patients for particularly laying particular stress on diarrhea due to damp-heat symptom have good curative effect.More
It is good afterwards.
It is below the several model cases using embodiment of the present invention sample treatment：
Case 1：××, female, 55 years old, diarrhea with loose stool was more than 1 year.Cardinal symptom is：Rise after morning just, per letting out after the meal, press from both sides
There is paddy, food greasy food increases, has loose bowels 4-6 time daily, with inappetence, distension and fullness in the abdomen, lassitude, shallow complexion.Tongue
Matter is light, and the thin greasy, moderate pulse of indentations at the margin of the tongue, yellow fur is weak.Take the embodiment of the present invention 1, orally, one time 4,3 times a day.After 2 days
Times of defecation is reduced to 3-4 time, and after 3 days, stool is reduced to 2-3 time, and after 5 days, stool is normal, recovery from illness.
Case 2：Poplar ××, man, 18 years old, has loose bowels in family 2 days.Cardinal symptom is：Day arranges yellowish-brown dilute watery stool about 5--7
Secondary, amount is medium, and without vomiting, without dehydration, without heating and cough with asthma, without irritated and tic, urine is normal.The embodiment of the present invention 2 is taken,
Orally, one time 4,3 times a day.After 1 day, times of defecation is reduced to 3-4 time, and after 3 days, stool is normal, recovery from illness.
Case 3：River ××, man, 48 years old, diarrhea due to damp-heat 2 days.Cardinal symptom is：Yellow skin is brown for stool, burning sensation of the anus, dysphoria with smothery sensation,
Thirsty, stomachache, yellowish fur, 4-6 times/day of times of defecation.Take the embodiment of the present invention 3, orally, one time 4,3 times a day.1
Times of defecation is reduced to 2-3 time in the future, and after 3 days, stool is normal, recovery from illness.
10056 although the present invention and its advantages have been described in detail, it should be appreciated that do not offseting the spirit and scope of the present invention
It is interior, can make a variety of changes, replace and change.Additionally, the scope of present invention application is not limited to what is described in description
Process, manufacture, material composition, mode, the specific embodiment of method and steps.From the disclosure of the present invention, those skilled in the art
By easily using substantially performing and corresponding embodiment identical function described herein or realize the existing of identical result
Or later by the process of exploitation, machine, manufacture, material composition, mode, method or step.Therefore, claims are intended to bag
Include these processes, machine, manufacture, material composition, mode, method or step.
Claims (10)
1. a kind of medicine for treating diarrhea due to damp-heat, it is characterised in that raw material is made up of the Chinese medicine of following weight portion：Fruticose Breyniae Leaf and Twig 10-
30 parts, grass 10-25 parts, Radix Puerariae 10-30 parts, Rhizoma Cimicifugae 5-20 parts, Semen Coiciss 10-15 parts, Cortex Magnoliae Officinalis 10-15 part, Rhizoma Atractylodis Macrocephalae 6-15 parts,
Radix Codonopsis 3-9 parts, Pericarpium Citri Reticulatae 3-6 parts, Radix Glycyrrhizae 1-5 parts.
2. it is according to claim 1 treatment diarrhea due to damp-heat medicine, it is characterised in that Chinese medicine of the raw material by following weight portion
Composition：20 parts of Fruticose Breyniae Leaf and Twig, 20 parts of grass, 20 parts of Radix Puerariae, 15 parts of Rhizoma Cimicifugae, 12 parts of Semen Coiciss, 12 parts of Cortex Magnoliae Officinalis, 10 parts of the Rhizoma Atractylodis Macrocephalae, Radix Codonopsis 6
Part, 5 parts of Pericarpium Citri Reticulatae, 3 parts of Radix Glycyrrhizae.
3. it is according to claim 1 and 2 treatment diarrhea due to damp-heat medicine, it is characterised in that the medicine preparation is into pharmacy
Any preparation of upper permission.
4. it is according to claim 1 and 2 treatment diarrhea due to damp-heat medicine, it is characterised in that the medicine preparation is into capsule
Agent, tablet, powder, granule, pill or oral liquid.
5. it is according to claim 1 and 2 treatment diarrhea due to damp-heat medicine, it is characterised in that the medicine preparation is into capsule
Agent.
6. a kind for the treatment of diarrhea due to damp-heat medicine as claimed in claim 5 makes the preparation method of capsule, it is characterised in that include
Following steps：
S1：Raw material is weighed respectively by following weight portion：Fruticose Breyniae Leaf and Twig's 10-30 parts, grass 10-25 parts, Radix Puerariae 10-30 parts, Rhizoma Cimicifugae 5-
20 parts, Semen Coiciss 10-15 parts, Cortex Magnoliae Officinalis 10-15 part, Rhizoma Atractylodis Macrocephalae 6-15 parts, Radix Codonopsis 3-9 parts, Pericarpium Citri Reticulatae 3-6 parts, Radix Glycyrrhizae 1-5 parts；
S2：By load weighted raw material, plus 6-10 times is measured water, is decocted and is extracted 1-3 time, and each 1-3 hours are filtered, and merging filtrate is dense
Clear paste of the relative density for 1.15-1.25 when being reduced to 60 DEG C；
S3：Qinghuo reagent, adds 95% ethanol to be 50-60% to clear paste alcohol content, stands 24～48h, filtration, filter at 5～10 DEG C
Thick paste of the relative density for 1.20-1.35 when liquid is concentrated into 60 DEG C；
S4：Filler, binding agent being added in thick paste, being mixed, granulation is dried, obtains dry particl；
S5：Lubricant is added in dry particl, is mixed, loaded capsule, obtain final product.
7. the preparation method of diarrhea due to damp-heat medicine is treated according to claim 6, it is characterised in that the filler is shallow lake
One or more combinations in powder, Microcrystalline Cellulose, Lactose and dextrin.
8. the preparation method of diarrhea due to damp-heat medicine is treated according to claim 6, it is characterised in that described adhesive is starch
Slurry, sodium carboxymethyl cellulose, hydroxypropyl cellulose, methylcellulose, ethyl cellulose, hydroxypropyl methyl cellulose, sucrose are molten
One or more combinations in liquid, the aqueous solution of polyvinylpyrrolidone or alcoholic solution.
9. the preparation method of diarrhea due to damp-heat medicine is treated according to claim 6, it is characterised in that the lubricant is Hard Fat
One or more combinations in sour magnesium, Pulvis Talci and silicon dioxide.
10. it is according to claim 1 and 2 treatment diarrhea due to damp-heat medicine, it is characterised in that the medicine prepare treatment
Purposes in the medicine of diarrhea due to damp-heat disease.
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| CN102406887A (en) * | 2011-12-02 | 2012-04-11 | 赵明芳 | Traditional Chinese medicine composition for treating chronic diarrhea and preparation method thereof |
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