CN102406887A - Traditional Chinese medicine composition for treating chronic diarrhea and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating chronic diarrhea and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine composition for treating chronic diarrhea. The traditional Chinese medicine composition is prepared from the following components: 100-150 parts of cortex fraxini, 100-150 parts of bighead atractylodes rhizome (fried), 100-150 parts of Chinese yam, 100-150 parts of rhizoma smilacis glabrae, 60-100 parts of codonopsis, 60-100 parts of coix seed, 60-100 parts of magnolia bark, 60-100 parts of cynomorium, 60-100 parts of radix sileris, 20-50 parts of radix paeoniae alba, 20-50 parts of kudzu root, 20-50 parts of angelica, 20-50 parts of cardamom, 20-50 parts of fructus aurantii, 10-30 parts of baked licorice and 10-30 parts of dried tangerine peel by pre-treating, pulverizing, extracting through decocting with water, mixing and drying, pulverizing, sub-packaging, sterilizing, packaging and other processes. The traditional Chinese medicine composition has the characteristics of high curative rate, short treatment course, low price, low recurrence rate, simpleness in preparation process, convenience in administration and easiness in acceptance by patients, and is proved to have definite treatment effect, safety in administration and controllable quality through clinical mass use for multiple years.
Description
Technical field
The Chinese medicine composition technical field of intestinal of relaxing that the present invention relates to be good for the stomach is a kind of Chinese medicine composition that is used to treat chronic diarrhea specifically, the invention still further relates to the method for preparing of this Chinese medicine composition.
Background technology
Chronic diarrhea is clinical frequently-occurring disease; Be found in the multiple lysis, diseases such as the various acute chronic enteritis in the western medicine, tuberculosis of intestine, intestinal malabsorption, bowel dysfunction, chronic dysentery, chronic ulcerative colitis, Crohn disease, functional dyspepsia, irritable bowel syndrome all belong to " having loose bowels " category of the traditional Chinese medical science.According to World Health Organization's statistics, the people in the whole world 72% suffers from enteritis, colitis in various degree.Stomachache, diarrhoea, tenesmus, mucopurulent bloody stool is enteritis, colitis common sympton, has loose bowels for a long time to cause various absorption of nutrient ingredients barrier tone tablets easily, causes malnutrition, becomes thin fatigue and weak, even disability, threat to life what is more.Modern medicine thinks, this disease and multiple reason cause intestinal secretion increase, move too fast, digest and assimilate bad relevant.The traditional Chinese medical science thinks that taste are hinges that human functional activity of vital energy goes up and down, and the up-down of taste mechanism of qi is the key that human functional activity of vital energy goes up and down, and has only the strong fortune of taste, just can keep lucid YANG ascending to the upper orifices, and turbid yin is walked lower orifices, lucid YANG replenishing four extremities, the normal function of turbid YIN moving through six FU-organs.So the traditional Chinese medical science thinks that the pathogenic factor of having loose bowels has in eating and drinking without temperance, unhygienic diet, the exopathogen and attack that daily life waits frequently and causes, also do not dredge with irritability; It is relevant that perverse and unreasonable manner is violated spleen; Have loose bowels and with the passing of time can damage kidney, cause that the kidney yin kidney yang is unbalance, cause resistance of human body to descend; How empty so have loose bowels, controlling should be from how dirty the starting with of liver spleen kidney.At present, western medical treatment should be decided in the disease uncertain therapeutic efficacy, also can cause the abuse of antibiotics sometimes.The Chinese traditional treatment chronic diarrhea is many starts with from taste, takes into account Liver and kidney, useful Cheng Fangzhe, and it is useful that what curative effect had reaches about 94% from the side of plan person, but the course of treatment is long, and medical expense is than higher.
Summary of the invention
Technical problem to be solved by this invention is that present Chinese traditional treatment chronic diarrhea is long the course of treatment; Medical expense is than higher; Thereby provide a kind of cure rate height, short treating period, expense low; And seldom have recurrence the treatment chronic diarrhea, in particular for the treatment ulcerative colitis a kind of Chinese medicine composition that is used to treat chronic diarrhea of desirable medication, the present invention also provides the method for preparing of this Chinese medicine composition.
Technical problem of the present invention adopts following technical proposals to solve:
A kind of Chinese medicine composition that is used to treat chronic diarrhea is prepared from following raw materials in weight portion medicine:
Cortex Fraxini 100-150 part, the Rhizoma Atractylodis Macrocephalae (stir-fry) 100-150 part, Rhizoma Dioscoreae 100-150 part, Rhizoma Smilacis Glabrae 100-150 part; Radix Codonopsis 60-100 part, Semen Coicis 60-100 part, Cortex Magnoliae Officinalis 60-100 part, Herba Cynomorii 60-100 part; Windproof 60-100 part, Radix Paeoniae Alba 20-50 part, Radix Puerariae 20-50 part, Radix Angelicae Sinensis 20-50 part; Fructus Amomi Rotundus 20-50 part, Fructus Aurantii 20-50 part, Radix Glycyrrhizae Preparata 10-30 part, Pericarpium Citri Reticulatae 10-30 part.
Said Chinese medicine composition prepares by following processing step:
(1) pre-treatment
Get Semen Coicis, Rhizoma Dioscoreae, Herba Cynomorii, Rhizoma Smilacis Glabrae, Cortex Magnoliae Officinalis, Cortex Fraxini, windproof, Rhizoma Atractylodis Macrocephalae (parched), Radix Codonopsis, the Radix Paeoniae Alba, Radix Puerariae, Radix Angelicae Sinensis, Fructus Amomi Rotundus, Fructus Aurantii, Radix Glycyrrhizae Preparata, Pericarpium Citri Reticulatae totally 16 flavor medical materials clean clean system, subsequent use;
(2) pulverize
Get Herba Cynomorii, Rhizoma Atractylodis Macrocephalae (parched), nutmeg and be broken into fine powder, cross 80 mesh sieves, subsequent use;
(3) water boiling and extraction
Semen Coicis, Rhizoma Dioscoreae, Rhizoma Smilacis Glabrae, Cortex Magnoliae Officinalis, Cortex Fraxini, windproof, Radix Codonopsis, the Radix Paeoniae Alba, Radix Puerariae, Radix Angelicae Sinensis, Fructus Aurantii, Radix Glycyrrhizae Preparata, Pericarpium Citri Reticulatae 13 flavors are put and added 8 times of water gagings in the multi-function extractor, soaked twice of heating decoction 0.5 hour; Each 2 hours; Leach decocting liquid, hold over night is got supernatant and is filtered; Filtrating is concentrated into the clear paste that relative density is 1.20～1.25 (50 ℃), and is subsequent use;
(4) mix oven dry, pulverize
Medicated powder and thick paste are put in the mixer, mix 30 minutes; Be divided into the piece of 3cm size, place 80 ℃ of oven dry of baking oven, water content was pulverized 80 mesh sieves 9%;
(5) packing
The medicated powder branch is filled in No. 0 capsule, and every 0.45g of loading amount removes defective capsule, polishing;
(6) sterilization
The capsule that branch is installed carries out radiation sterilization;
(7) packing
The capsule that branch is installed after the assay was approved, packing, warehouse-in.
Cortex Fraxini bowel relieving antidiarrheal among the side of the present invention; Windproof the lucid yang sending up antidiarrheal, Radix Puerariae expelling pathogenic factors from muscles bowel relieving antidiarrheal, decoction of four noble drugs air making-up and spleen enlivening; Add the Semen Coicis, Fructus Amomi Rotundus, Rhizoma Dioscoreae etc. that regulating the stomach to normalize QI, eliminating dampness by diuresis remove painful abdominal mass, alleviating distention in middle-JIAO and be all monarch-minister drug; The Radix Angelicae Sinensis and the Radix Paeoniae Alba are nourished blood, invigorating blood circulation is adjuvant drug, Pericarpium Citri Reticulatae, Cortex Magnoliae Officinalis, Fructus Aurantii regulating qi-flowing for strengthening spleen antidiarrheal, the messenger drug in the Herba Cynomorii reinforcing spleen and kidney side of being.
Rhizoma Dioscoreae contains Saponin, phlegmatic temperament, choline, glycoprotein, polyphenol oxidase, vitamin C etc. in the side, and Saponin is mainly dioscin, water-soluble, ethanol; The Radix Paeoniae Alba mainly contains paeoniflorin, and contains small amount of hydroxyl groups Radix Paeoniae Saponin, peony lactone and benzoylpaeoniflorin etc., and water solublity is better; The Radix Codonopsis Main Ingredients and Appearance is saponin, polysaccharide, inulin, fructose etc. and 17 seed amino acids, and is all water-soluble; Windproof volatile oil, mannitol, the bitterness glycoside etc. of containing, water boiling and extraction can be come out most extracts active ingredients; Semen Coicis mainly contains the Semen Coicis ester, in addition carbohydrate containing, fat, protein and steroid, aminoacid etc.; Rhizoma Smilacis Glabrae contains steroidal saponin, tannin, resin etc.; Cortex Magnoliae Officinalis master contains volatile oil, and other contains magnolol, honokiol and magnocurarine; Cortex Fraxini contains Coumarins compositions such as aesculin (in alkali liquor, showing blue-fluorescence) and esculiw, and other contains tannin and alkaloid; Fructus Aurantii contains volatile oil and flavones ingredient, and flavones ingredient has Hesperidin, neohesperidin, naringin, aurantiamaric acid etc.; Radix Angelicae Sinensis mainly contains volatile oil, and other contains volume sucrose, vitamin B
12, ferulic acid and ferulate, ferulate is soluble in water; Radix Puerariae contains Flavonoid substances, wherein is mainly: daidzin, daidzein and puerarin etc., and flavone and flavonoid glycoside are water-soluble; Radix Glycyrrhizae contains the triterpenoid compound glycyrrhizin, mainly is the potassium calcium salt of glycyrrhizic acid, and glycyrrhizic acid is through being hydrolyzed to enoxolone, and Radix Glycyrrhizae still contains liquiritin, liquiritigenin, isoliquiritin etc.; Pericarpium Citri Reticulatae still contains flavone compound except that containing volatile oil, Hesperidin, Pericarpium Citri tangerinae element, neohesperidin etc. are arranged, more than effective ingredient water solublity in ten four Chinese medicines better, so adopt water boiling and extraction technology.Fructus Amomi Rotundus contains volatile oil, fatty oil, starch, protein etc.; Herba Cynomorii contains anthocyanin, triterpenoid saponin and several amino acids and saccharides such as tannin and proline; The Rhizoma Atractylodis Macrocephalae contains volatile oil such as atractylone, atractylodes lactone A, atractylodes lactone B, celery alkane dienone, and other contains vitamin A, Fructus Amomi Rotundus, Rhizoma Atractylodis Macrocephalae volatile oil content height; Volatile oil is water insoluble; In order to guarantee its curative effect, reduce filler, we are used as medicine three flavor medical materials with the former powder of medical material.Still this production technology confirmed as the part medical material decoct to extract, the part medical material is used as medicine with the former powder of crude drug.
The used side's medicine of the present invention prescription is rigorous, and the medicine source is sufficient, develops according to the differentiation of tcm principle; Cure rate height, short treating period, medicine valency are low, and recurrence is seldom arranged, preparation technology's letter and not numerous; Taking convenience; Being accepted by the patient easily, is the treatment chronic diarrhea, especially for treating the desirable medication of ulcerative colitis.Preparing process route of the present invention fully extracts the active ingredient of prescription medical material, has guaranteed these article curative effect, largely dwindles the medicine volume again, facilitates patients.Through clinical a large amount of use for many years, determined curative effect is taken safety, and is quality controllable.This medicine treatment chronic diarrhea, through clinical observation, total effective rate reaches 100%.
The usage and dosage of this Chinese medicine composition: oral, one time 6～8,3 times on the one, or follow the doctor's advice.
The specific embodiment
Embodiment 1
(1) pre-treatment: get Cortex Fraxini 100g, Rhizoma Dioscoreae 100g, Rhizoma Smilacis Glabrae 150g, Radix Codonopsis 60g, Semen Coicis 60g; Cortex Magnoliae Officinalis 100g, windproof 100g, Radix Paeoniae Alba 20g, Radix Puerariae 20g, Radix Angelicae Sinensis 50g; Fructus Aurantii 50g, Radix Glycyrrhizae Preparata 10g, Pericarpium Citri Reticulatae 30g is by " process of preparing Chinese medicine of Chinese pharmacopoeia version in 2005 is clean medical material, drying for standby;
(2) pulverize: get Herba Cynomorii 60g, Rhizoma Atractylodis Macrocephalae (parched) 100g, Fructus Amomi Rotundus 20g and be ground into fine powder, cross 80 mesh sieves, subsequent use;
(3) water boiling and extraction
Semen Coicis, Rhizoma Dioscoreae, Rhizoma Smilacis Glabrae, Cortex Magnoliae Officinalis, Cortex Fraxini, windproof, Radix Codonopsis, the Radix Paeoniae Alba, Radix Puerariae, Radix Angelicae Sinensis, Fructus Aurantii, Radix Glycyrrhizae Preparata, Pericarpium Citri Reticulatae 13 flavors are put and added 7.6kg water in the multi-function extractor, soaked twice of heating decoction 0.5 hour; Each 2 hours; Leach decocting liquid, hold over night is got supernatant and is filtered; Filtrating is concentrated into the clear paste that relative density is 1.20 (50 ℃), and is subsequent use;
(4) mix oven dry, pulverizing
Medicated powder and thick paste are put in the mixer, mix 30 minutes; Be divided into the piece of 3cm size, place 80 ℃ of oven dry of baking oven, water content 9% was pulverized 80 mesh sieves;
(5) packing: get qualified medicated powder, divide to be filled in No. 0 capsule, every 0.45g of loading amount selects, and removes defective capsule, polishing.
(6) sterilization: the capsule that branch is installed carries out radiation sterilization.
(7) packing: the capsule that branch is installed send the Drug Control Room check, qualified after, packing, every bottled 36, send the Drug Control Room check, qualified after, warehouse-in promptly gets.
Embodiment 2
(1) pre-treatment: with Cortex Fraxini 150g, Rhizoma Dioscoreae 150g, Rhizoma Smilacis Glabrae 100g, Radix Codonopsis 100g, Semen Coicis 100g; Cortex Magnoliae Officinalis 60g, windproof 60g, Radix Paeoniae Alba 50g, Radix Puerariae 50g, Radix Angelicae Sinensis 20g; Fructus Aurantii 20g, Radix Glycyrrhizae Preparata 30g, Pericarpium Citri Reticulatae 10g is by " process of preparing Chinese medicine of Chinese pharmacopoeia version in 2005 is clean medical material, drying for standby;
(2) pulverize: get Herba Cynomorii 100g, Rhizoma Atractylodis Macrocephalae (parched) 150g, Fructus Amomi Rotundus 50g and be ground into fine powder, cross 80 mesh sieves, subsequent use;
(3) water boiling and extraction
Get Semen Coicis, Rhizoma Dioscoreae, Rhizoma Smilacis Glabrae, Cortex Magnoliae Officinalis, Cortex Fraxini, windproof, Radix Codonopsis, the Radix Paeoniae Alba, Radix Puerariae, Radix Angelicae Sinensis, Fructus Aurantii, Radix Glycyrrhizae Preparata, Pericarpium Citri Reticulatae 13 flavors are put and are added 7.2kg water in the multi-function extractor, soak twice of heating decoction 0.5 hour; Each 2 hours; Leach decocting liquid, hold over night is got supernatant and is filtered; Filtrating is concentrated into the clear paste that relative density is 1.25 (50 ℃), and is subsequent use.
(4) mix oven dry, pulverize
Medicated powder and thick paste are put in the mixer, mix 30 minutes; Be divided into the piece of 3cm size, place 70 ℃ of oven dry of baking oven, water content 8% was pulverized 80 mesh sieves.
(5) packing: the medicated powder branch is filled in No. 0 capsule, and every 0.45g of loading amount removes defective capsule, polishing.
(6) sterilization: the capsule that branch is installed carries out radiation sterilization.
(7) packing: the capsule that branch is installed after the assay was approved, packing, warehouse-in.
The clinical efficacy report
1 data and method
1.1 physical data: 120 routine chronic diarrhea patients are divided into two groups by the table of random number method, and the easypro intestinal capsule of spleen invigorating is the treatment group, and Montmorillonitum looses and is matched group, and wherein 60 examples are organized in treatment; Man's 33 examples, women 27 examples, age 16.5-65 year; Average 35 ± 0.8 years old, the course of disease 6 months-5 years, average 2 ± 0.6 years; Matched group 60 examples, male 32 examples, women 28 examples, age 17-65.5 year, average 36.8 ± 0.5 years old, the course of disease 6 months-5 years, average 2 ± 0.5 years.Two groups of ages, sex, courses of disease there are no significant difference (
P>0.05), two groups have comparability.
1.2 diagnostic criteria: all case is clarified a diagnosis in conjunction with the diagnostic criteria of modern medicine chronic diarrhea with reference to the diagnostic criteria of " chronic diarrhea " in " Chinese Internal Medicine " the 5th edition teaching material.
1.3 Therapeutic Method: concrete grammar is that 120 routine chronic diarrhea patients are divided into two groups by the table of random number method, and treatment group 60 examples are oral from intending the happy capsule for treating of spleen invigorating, each 4-6 grain, every day 3 times, totally 2 weeks; Matched group 60 routine oral Montmorillonitums loose, each 3g, every day 3 times, totally 2 weeks.
1.4 curative effect determinate standard: according to " traditional Chinese medical science disease diagnosis criterion of therapeutical effect " evaluation of State Administration of Traditional Chinese Medicine of People's Republic of China (PRC) issue.Cure: stool is normal, other transference cures, and Clinical Laboratory is normal; Take a turn for the better: times of defecation obviously reduces, other doing well,improvings; Do not heal: symptom is not seen improvement.
The result
Two groups of treatment back clinical efficacies are relatively seen table 1.Two groups of cure rates and total effective rate relatively, difference have the significance meaning (
P<0.05).
Table 1 liang group treatment back clinical efficacy relatively
| Group | The example number | Cure | Take a turn for the better | Do not heal | Cure rate | Total effective rate (%) |
| The treatment group | 60 | 38 | 20 | 2 | 63.33 | 96.66 |
| Matched group | 60 | 18 | 25 | 27 | 30.00 | 71.66 |
Claims (2)
1. Chinese medicine composition that is used to treat chronic diarrhea is prepared from following raw materials in weight portion medicine:
Cortex Fraxini 100-150 part, the Rhizoma Atractylodis Macrocephalae (stir-fry) 100-150 part, Rhizoma Dioscoreae 100-150 part, Rhizoma Smilacis Glabrae 100-150 part; Radix Codonopsis 60-100 part, Semen Coicis 60-100 part, Cortex Magnoliae Officinalis 60-100 part, Herba Cynomorii 60-100 part; Windproof 60-100 part, Radix Paeoniae Alba 20-50 part, Radix Puerariae 20-50 part, Radix Angelicae Sinensis 20-50 part; Fructus Amomi Rotundus 20-50 part, Fructus Aurantii 20-50 part, Radix Glycyrrhizae Preparata 10-30 part, Pericarpium Citri Reticulatae 10-30 part.
2. one kind prepares the method for Chinese medicine composition according to claim 1, prepares by following processing step:
(1) pre-treatment
Get Semen Coicis, Rhizoma Dioscoreae, Herba Cynomorii, Rhizoma Smilacis Glabrae, Cortex Magnoliae Officinalis, Cortex Fraxini, windproof, Rhizoma Atractylodis Macrocephalae (parched), Radix Codonopsis, the Radix Paeoniae Alba, Radix Puerariae, Radix Angelicae Sinensis, Fructus Amomi Rotundus, Fructus Aurantii, Radix Glycyrrhizae Preparata, Pericarpium Citri Reticulatae totally 16 flavor medical materials clean clean system, subsequent use;
(2) pulverize
Get Herba Cynomorii, Rhizoma Atractylodis Macrocephalae (parched), nutmeg and be broken into fine powder, cross 80 mesh sieves, subsequent use;
(3) water boiling and extraction
Semen Coicis, Rhizoma Dioscoreae, Rhizoma Smilacis Glabrae, Cortex Magnoliae Officinalis, Cortex Fraxini, windproof, Radix Codonopsis, the Radix Paeoniae Alba, Radix Puerariae, Radix Angelicae Sinensis, Fructus Aurantii, Radix Glycyrrhizae Preparata, Pericarpium Citri Reticulatae 13 flavors are put and added 8 times of water gagings in the multi-function extractor, soaked twice of heating decoction 0.5 hour; Each 2 hours; Leach decocting liquid, hold over night is got supernatant and is filtered; Filtrating is concentrated into the clear paste that relative density is 1.20～1.25 (50 ℃), and is subsequent use;
(4) mix oven dry, pulverize
Medicated powder and thick paste are put in the mixer, mix 30 minutes; Be divided into the piece of 3cm size, place 80 ℃ of oven dry of baking oven, water content was pulverized 80 mesh sieves 9%;
(5) packing
The medicated powder branch is filled in No. 0 capsule, and every 0.45g of loading amount removes defective capsule, polishing;
(6) sterilization
The capsule that branch is installed carries out radiation sterilization;
(7) packing
The capsule that branch is installed after the assay was approved, packing, warehouse-in.
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| CN102698145A (en) * | 2012-06-19 | 2012-10-03 | 大连民族学院 | Chinese medicine preparation for tonifying spleen and stopping diarrhea |
| CN103212001A (en) * | 2013-03-22 | 2013-07-24 | 赵霞 | Chinese medicinal composition treating diarrhoea |
| CN103768305A (en) * | 2013-09-22 | 2014-05-07 | 李柏群 | Medicine for treating spleen-deficiency diarrhea type IBS (Irritable Bowel Syndrome) and manufacturing method thereof |
| CN105213886A (en) * | 2015-10-19 | 2016-01-06 | 青岛市中心医院 | Be used for the treatment of the medicine of chronic non-specific ulcerative colitis |
| CN106474226A (en) * | 2016-11-30 | 2017-03-08 | 广西万德药业有限公司 | A kind of medicine for treating chronic diarrhea |
| CN106511559A (en) * | 2016-11-30 | 2017-03-22 | 广西万德药业有限公司 | Medicine for treating damp-heat diarrhea and preparation method of medicine |
| CN106619930A (en) * | 2016-11-30 | 2017-05-10 | 广西南宁桂知科技有限公司 | Medicine composition containing radix puerariae and preparation method of medicine composition |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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| CN103768305A (en) * | 2013-09-22 | 2014-05-07 | 李柏群 | Medicine for treating spleen-deficiency diarrhea type IBS (Irritable Bowel Syndrome) and manufacturing method thereof |
| CN105213886A (en) * | 2015-10-19 | 2016-01-06 | 青岛市中心医院 | Be used for the treatment of the medicine of chronic non-specific ulcerative colitis |
| CN106474226A (en) * | 2016-11-30 | 2017-03-08 | 广西万德药业有限公司 | A kind of medicine for treating chronic diarrhea |
| CN106511559A (en) * | 2016-11-30 | 2017-03-22 | 广西万德药业有限公司 | Medicine for treating damp-heat diarrhea and preparation method of medicine |
| CN106619930A (en) * | 2016-11-30 | 2017-05-10 | 广西南宁桂知科技有限公司 | Medicine composition containing radix puerariae and preparation method of medicine composition |
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