CN106474528A - 一种可吸收抗菌医用敷料的制备方法 - Google Patents

一种可吸收抗菌医用敷料的制备方法 Download PDF

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CN106474528A
CN106474528A CN201611082094.7A CN201611082094A CN106474528A CN 106474528 A CN106474528 A CN 106474528A CN 201611082094 A CN201611082094 A CN 201611082094A CN 106474528 A CN106474528 A CN 106474528A
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李苏扬
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Jiangsu Jingwei Technology Innovation Consulting Co Ltd
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Abstract

本发明公开了一种可吸收抗菌医用敷料的制备方法，该制备方法包括以下步骤：（1）按重量取蚕丝蛋白，用水混合；（2）向蚕丝蛋白的水溶液中加入壳聚糖、胶原蛋白、金银花粉末，加入后再进行充分搅拌，搅拌均匀，为A组份；（3）按重量另取医用发泡剂、胶原肽、几丁聚糖、水，加热搅拌至均匀，为B组份；（4）将A组份和B组份混合，再加入热水搅拌，即得可吸收抗菌医用敷料。通过本发明的方法制备的可吸收抗菌医用敷料发泡效果好、吸附能力高、保湿性强、柔软可塑性强；无毒，生物相容性高；具有抑制细菌生长、阻止细菌进入创面，促进皮肤再生，加速愈合等优点。

Description

一种可吸收抗菌医用敷料的制备方法
技术领域
本发明属于医用新材料领域，涉及一种可吸收抗菌医用敷料的制备方法。
技术背景
皮肤创伤为临床常见疾病，为避免遭细菌感染及其它外来因素的影响，保护并促进创面愈合、促进组织修复，常在各种创伤、创口表面进行临时覆盖医用敷料。临床常用敷料多以纱布、医用脱脂棉等材料为主，虽然成本低，原料来源广泛，制作简单，具有较强的吸收能力，但止血效果欠佳，无创面保湿作用，易导致二次损伤，创伤面的积液容易引起细菌感染等等。医用敷料，是包伤的用品，用以覆盖疮、伤口或其他损害的医用材料。医用敷料作为伤口处的覆盖物，使其暂时起到皮肤屏障功能的部分作用，提供一个有利于创面愈合的环境，等待创面上皮化或过渡到重建永久性的皮肤屏障。随着对创面愈合过程的病理生理的深入研究，人们对创面愈合过程的理解也越来越深刻，从而推动了创面敷料的不断改进与发展。今天，新型的创面敷料相对于早期已经发生了革命性的变化，从被动型敷料，发展到相互作用型敷料，继之演变到现今的生物活性敷料。理想的创面敷料应满足以下要求：防止水份与体液的损失；抵御细菌入侵，防止感染；与创面有亲合性，有较好的粘合力；保持、促进肉芽和上皮组织正常生长，促进痊愈；不留疤痕、不产生变形；柔软，有一定机械强度；透气，透湿，有保湿性；生物相容性好；舒适、方便，制备容易，价格低廉。覆盖创面的最理想的方法是自体皮移植，但是移植皮源往往不足。随着高分子工业的发展，合成材料制备的敷料也日益增多，大致有薄膜类、液体类、喷雾类、泡沫类、水凝胶类等。目前业界投入生产临床使用的抗菌敷料普遍存在抗菌效果不理想、与伤口粘连等问题，因此仍有待于进一步提高和改善其抗菌效果和与皮肤组织的粘连等问题。
发明内容
本发明的目的在于针对现有技术的不足，提供一种抗菌性能好的可吸收抗菌医用敷料的制备方法。
本发明的目的是通过以下技术方案实现的： 一种可吸收抗菌医用敷料的制备方法，该制备方法包括以下步骤：（1）按重量取蚕丝蛋白12-20份，用10-14份水混合；（2）向蚕丝蛋白的水溶液中加入壳聚糖10-15份、胶原蛋白1-3份、金银花粉末0.5-1.5份，加入后再进行充分搅拌，搅拌均匀，为A组份；（3）按重量另取医用发泡剂3-13份、胶原肽4-12份、几丁聚糖0.5-1.5份、水10-14份，加热搅拌至均匀，为B组份；（4）将A组份和B组份混合，再加入45-80℃热水15-18份加以搅拌1.5-2h，即得可吸收抗菌医用敷料。 所述金银花粉末为金银花在-50℃的真空下，冷冻干燥后粉碎得到的纳米颗粒，粒径为100~1000nm。所述医用发泡剂选自吐温、泊洛沙姆、司盘、甘油脂肪酸酯、山梨醇脂肪酸酯中的至少一种。所述壳聚糖的脱乙酰度为80-95%。
所述步骤（3）中加热温度为50-65℃。
本发明具有以下有益效果：通过本发明的方法制备的可吸收抗菌医用敷料发泡效果好、吸附能力高、保湿性强、柔软可塑性强；无毒，生物相容性高；具有抑制细菌生长、阻止细菌进入创面，促进皮肤再生，加速愈合等优点。
具体实施方式
实施例1
一种可吸收抗菌医用敷料的制备方法，该制备方法包括以下步骤：（1）按重量取蚕丝蛋白12份，用10份水混合；（2）向蚕丝蛋白的水溶液中加入壳聚糖10份、胶原蛋白1份、金银花粉末0.5份，加入后再进行充分搅拌，搅拌均匀，为A组份；（3）按重量另取医用发泡剂3份、胶原肽4份、几丁聚糖0.5份、水10份，加热搅拌至均匀，为B组份；（4）将A组份和B组份混合，再加入45-80℃热水15份加以搅拌1.5-2h，即得可吸收抗菌医用敷料。 所述金银花粉末为金银花在-50℃的真空下，冷冻干燥后粉碎得到的纳米颗粒，粒径为100~1000nm。所述医用发泡剂选自吐温、泊洛沙姆、司盘、甘油脂肪酸酯、山梨醇脂肪酸酯中的至少一种。所述壳聚糖的脱乙酰度为80-95%。
所述步骤（3）中加热温度为50-65℃。
实施例2
一种可吸收抗菌医用敷料的制备方法，该制备方法包括以下步骤：（1）按重量取蚕丝蛋白20份，用14份水混合；（2）向蚕丝蛋白的水溶液中加入壳聚糖15份、胶原蛋白3份、金银花粉末1.5份，加入后再进行充分搅拌，搅拌均匀，为A组份；（3）按重量另取医用发泡剂13份、胶原肽12份、几丁聚糖1.5份、水14份，加热搅拌至均匀，为B组份；（4）将A组份和B组份混合，再加入45-80℃热水15-18份加以搅拌1.5-2h，即得可吸收抗菌医用敷料。 所述金银花粉末为金银花在-50℃的真空下，冷冻干燥后粉碎得到的纳米颗粒，粒径为100~1000nm。所述医用发泡剂选自吐温、泊洛沙姆、司盘、甘油脂肪酸酯、山梨醇脂肪酸酯中的至少一种。所述壳聚糖的脱乙酰度为80-95%。
所述步骤（3）中加热温度为50-65℃。
实施例3
一种可吸收抗菌医用敷料的制备方法，该制备方法包括以下步骤：（1）按重量取蚕丝蛋白16份，用12份水混合；（2）向蚕丝蛋白的水溶液中加入壳聚糖13份、胶原蛋白2份、金银花粉末1份，加入后再进行充分搅拌，搅拌均匀，为A组份；（3）按重量另取医用发泡剂8份、胶原肽8份、几丁聚糖1份、水12份，加热搅拌至均匀，为B组份；（4）将A组份和B组份混合，再加入45-80℃热水17份加以搅拌1.5-2h，即得可吸收抗菌医用敷料。 所述金银花粉末为金银花在-50℃的真空下，冷冻干燥后粉碎得到的纳米颗粒，粒径为100~1000nm。所述医用发泡剂选自吐温、泊洛沙姆、司盘、甘油脂肪酸酯、山梨醇脂肪酸酯中的至少一种。所述壳聚糖的脱乙酰度为80-95%。
所述步骤（3）中加热温度为50-65℃。

Claims (5)

1.一种可吸收抗菌医用敷料的制备方法，其特征在于该制备方法包括以下步骤：（1）按重量取蚕丝蛋白12-20份，用10-14份水混合；（2）向蚕丝蛋白的水溶液中加入壳聚糖10-15份、胶原蛋白1-3份、金银花粉末0.5-1.5份，加入后再进行充分搅拌，搅拌均匀，为A组份；（3）按重量另取医用发泡剂3-13份、胶原肽4-12份、几丁聚糖0.5-1.5份、水10-14份，加热搅拌至均匀，为B组份；（4）将A组份和B组份混合，再加入45-80℃热水15-18份加以搅拌1.5-2h，即得可吸收抗菌医用敷料。
2.根据权利要求1所述的一种可吸收抗菌医用敷料的制备方法，其特征在于所述金银花粉末为金银花在-50℃的真空下，冷冻干燥后粉碎得到的纳米颗粒，粒径为100~1000nm。
3.根据权利要求1所述的一种可吸收抗菌医用敷料的制备方法，其特征在于所述医用发泡剂选自吐温、泊洛沙姆、司盘、甘油脂肪酸酯、山梨醇脂肪酸酯中的至少一种。
4.根据权利要求1所述的一种可吸收抗菌医用敷料的制备方法，其特征在于所述壳聚糖的脱乙酰度为80-95%。
5.根据权利要求1所述的一种可吸收抗菌医用敷料的制备方法，其特征在于所述步骤（3）中加热温度为50-65℃。
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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107648205A (zh) * 2017-10-19 2018-02-02 北京九鼎君健医药科技项城有限公司 一种促进伤口愈合的胶原肽敷料及其制备方法
CN107802527A (zh) * 2017-12-12 2018-03-16 中国药科大学 利用食用菌来源复合敷料制备的粉饼及其制备方法
CN112121223A (zh) * 2020-10-16 2020-12-25 河南民兴生物科技股份有限公司 一种丝胶蛋白的医用敷料及其生产方法
CN114832150A (zh) * 2022-04-15 2022-08-02 北京天珠药业有限公司 一种抗菌收敛创口促进屏障修复的喷剂敷料

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107648205A (zh) * 2017-10-19 2018-02-02 北京九鼎君健医药科技项城有限公司 一种促进伤口愈合的胶原肽敷料及其制备方法
CN107648205B (zh) * 2017-10-19 2021-09-24 北京九鼎君健医药科技项城有限公司 一种促进伤口愈合的胶原肽敷料及其制备方法
CN107802527A (zh) * 2017-12-12 2018-03-16 中国药科大学 利用食用菌来源复合敷料制备的粉饼及其制备方法
CN112121223A (zh) * 2020-10-16 2020-12-25 河南民兴生物科技股份有限公司 一种丝胶蛋白的医用敷料及其生产方法
CN114832150A (zh) * 2022-04-15 2022-08-02 北京天珠药业有限公司 一种抗菌收敛创口促进屏障修复的喷剂敷料

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