CN106466356A - A kind of Cortex Jujubae relieving diarrhea with astringents bath effervescent tablets and preparation method thereof - Google Patents
A kind of Cortex Jujubae relieving diarrhea with astringents bath effervescent tablets and preparation method thereof Download PDFInfo
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- CN106466356A CN106466356A CN201510513525.XA CN201510513525A CN106466356A CN 106466356 A CN106466356 A CN 106466356A CN 201510513525 A CN201510513525 A CN 201510513525A CN 106466356 A CN106466356 A CN 106466356A
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Abstract
A kind of Cortex Jujubae relieving diarrhea with astringents bath effervescent tablets and preparation method thereof, it is made up by following percentage by weight of raw material, Chinese medicine extract 20-35%, sour agent 10-20%, alkaline agent 10-20%, filler 30-50%, binding agent 1-10%, lubricant 1-10%, aromatic 0.1-1%；Raw materials by weight portion in described Chinese medicine extract, Cortex Jujubae 50-70 part, Radix Morindae Officinaliss 15-20 part, Radix Serissae 15-20 part, Herba Inulae cappae 8-12 part, Rhizoma Cynanchi Stauntonii 8-12 part, Fructus Perillae Frutescentiss 5-8 part, Huaihe River wood 5-8 part, winged euonymus 5-8 part, Resina Toxicodendri 5-8 part, Soviet Union's core 5-8 part, the mainly comprising the following steps of preparation method：Step 1, prepare Chinese medicine extract：Clean, remove impurity, mixing, extraction；Step 2, mixing：Prepare acid particles, prepare alkali grain, mixing, tabletting.A kind of Cortex Jujubae relieving diarrhea with astringents bath effervescent tablets of the present invention, life-time service has functions that relieving diarrhea with astringents, antitussive hemostasis, wind-dispelling.
Description
Technical field
The present invention relates to a kind of health body-wash articles for use, particularly a kind of Cortex Jujubae relieving diarrhea with astringents bath effervescent tablets and preparation method thereof.
Background technology
In the traditional Chinese medical science, dipping method is one of external treatment, that is, use medicinal liquid or a kind of method containing medicinal liquid water washing bath whole body or local, and its form is varied：Have full bath and claim " liquid medicine bath "；The title again having " scalding ", " fumigation and wash method ", " demibain ", " foot bath " etc. of local bathing, especially scalds the most commonly used.
Chinese dipping, have existed since ancient times.Earliest hospital of China<52 Bingfang>In just have the dipping side controlling baby's epilepsy.《Book of Rites》In say " head has skin ulcer then to wash one's hair, and body has infectionss then to bathe ",《Huang di's Canon of Medicine》In have the record of " its be subject to exopathogen person, bathing the body with hot decoction to induce diaphoresis ", can say, the history of dipping is of long standing and well established, be laid a foundation in the Qin Dynasty, be developed in Chinese Tang, enrich in Song Ming, ripe in the Qing Dynasty.
The common dipping species in current market is broadly divided into three classes, including：Full bath, demibain, foot bath, using method is also very simply it is only necessary in the liquid medicine having dissolved to the bidet entering to mix up water temperature and the water yield or bath bucket, then steep body in water；Client progressively can experience the change of body generation during bathing.
The dipping mechanism of action in general, be medicine act on whole body flesh table, locally, affected part, and through absorb, circulation meridians blood vessels, inside reach internal organs, from outward appearance to inner essence, thus produce effect.Dipping bathing, can play dredging the meridian, activating blood circulation to dissipate blood stasis, wind dispelling cold expelling, heat-clearing and toxic substances removing, reducing swelling and alleviating pain, regulating YIN and YANG, coordinate internal organs, current QI and blood, moisten the health maintenance effect such as foster whole body.Modern pharmacology also confirms that, can improve the content of some immunoglobulins in blood after dipping, strengthens elasticity and the vigor of skin.
Medicine used by dipping on market mostly is medicinal liquid or medicated powder, medicinal liquid or medicated powder is not portable, and composition easily runs off, and medicinal liquid that most of Chinese herbal medicine process or medicated powder cannot the sufficiently effective effective ingredient playing Chinese crude drug, loss or the waste of drug effect can be caused, and be prepared into effervescent tablet and be then easy to preserve and carry, dissolution velocity is fast, bioavailability is high, can improve clinical efficacy.
At present, the medicine of relieving diarrhea with astringents or health product have much on market, but the effect of most drug is not very well, and the side effect of most drug is more, and health can be damaged, and therefore, market is badly in need of a kind of
Cortex Jujubae relieving diarrhea with astringents bath effervescent tablets and preparation method thereof.
Content of the invention
It is an object of the invention to provide a kind of Cortex Jujubae relieving diarrhea with astringents bath effervescent tablets and preparation method thereof, life-time service has relieving diarrhea with astringents, antitussive is stopped blooding, wind action of dispelling.
The purpose of the present invention is achieved through the following technical solutions：
A kind of Cortex Jujubae relieving diarrhea with astringents bath effervescent tablets and preparation method thereof, it is made up by following percentage by weight of raw material, Chinese medicine extract 20-35%, sour agent 10-20%, alkaline agent 10-20%, filler 30-50%, binding agent 1-10%, lubricant 1-10%, aromatic 0.1-1%；Raw materials by weight portion in described Chinese medicine extract, Cortex Jujubae 50-70 part, Radix Morindae Officinaliss 15-20 part, Radix Serissae 15-20 part, Herba Inulae cappae 8-12 part, Rhizoma Cynanchi Stauntonii 8-12 part, Fructus Perillae Frutescentiss 5-8 part, Huaihe River wood 5-8 part, winged euonymus 5-8 part, Resina Toxicodendri 5-8 part, Soviet Union's core 5-8 part.
In described Chinese medicine extract, raw material presses optimum weight number, 60 parts of Cortex Jujubae, 18 parts of Radix Morindae Officinaliss, 17 parts of Radix Serissae, 12 parts of Herba Inulae cappae, 10 parts of Rhizoma Cynanchi Stauntonii, 8 parts of Fructus Perillae Frutescentiss, 7 parts of Huaihe River wood, 6 parts of winged euonymus, 5 parts of Resina Toxicodendri, 5 parts of core of Soviet Union.
Described sour agent is citric acid or tartaric acid or citric acid or fumaric acid.
Described alkaline agent is sodium carbonate or sodium bicarbonate.
Described filler is Microcrystalline Cellulose, sucrose, Lactose, sodium chloride, the calcium sulfate mixing of one or more therein.
Described binding agent is starch slurry or Microcrystalline Cellulose.
Described lubricant is the mixing of one of magnesium stearate, sodium lauryl sulphate or two kinds.
Described a kind of Cortex Jujubae relieving diarrhea with astringents bath effervescent tablets and preparation method thereof, the mainly comprising the following steps of its preparation method：
Step 1, prepare Chinese medicine extract：
a
, by weight, the Cortex Jujubae of selection high-quality, Radix Morindae Officinaliss, Radix Serissae, Herba Inulae cappae, Rhizoma Cynanchi Stauntonii, Fructus Perillae Frutescentiss, Huaihe River wood, winged euonymus, Resina Toxicodendri, Soviet Union's core, clean and remove impurity, mix homogeneously after remove impurity, add water to cook three times, the water small fire adding 12-15 times for the first time decocts 90-120 minute, filters, and extracts filtrate, second plus 10-12 times of water moderate heat decocts 60-90 minute, filter, extract filtrate, the water big fire that third time adds 6-8 times decocts 30-45 minute, filter, extract filtrate, mix three filtrates, obtain mixed extract；
b
, mixed extract is concentrated, be dried using spray dryer after concentration, obtain solid mixed extract, pulverized 60-80 mesh sieve, and obtained solid particle；
Step 2, mixing：
a
, the solid particle obtaining in step 1 is divided into uniform two parts, choose sour agent, alkaline agent, filler, binding agent, carry out respectively pulverizing 60 mesh sieves；
b
, first part of solid particle add the sour agent after pulverizing, filler, binding agent; it is then placed in trough type mixing machine; open trough type mixing machine to mix 30 minutes, add the PVP K30 ethanol solution that concentration is 1%, soft material processed into trough type mixing machine; add to soft material moderate after; soft material is put in oscillating granulator, makes granule, 60 eye mesh screen on oscillating granulator; dry, obtain acid particles；
c
, second part
Solid particle adds the alkaline agent after pulverizing, filler, binding agent; it is then placed in trough type mixing machine; open trough type mixing machine to mix 30 minutes, add the PVP K30 ethanol solution that concentration is 1%, soft material processed into trough type mixing machine; add to soft material moderate after; soft material is put in oscillating granulator, makes granule, 60 eye mesh screen on oscillating granulator; dry, obtain alkali grain；
d
, by acid particles, alkali grain, lubricant, aromatic mixing, put into tabletting in automatic tableting press after fully mixing, aluminum-plastic packaged, obtain a kind of Cortex Jujubae relieving diarrhea with astringents bath effervescent tablets.
In medicine：Cortex Jujubae relieving diarrhea with astringents；Antitussive is stopped blooding；Master has loose bowels；Dysentery；Cough；Metrorrhagia；Traumatic hemorrhage；Burn and scald；Radix Morindae Officinaliss kidney-replenishing, strengthening bone and muscle, wind-damp dispelling, control sexual impotence, few abdomen crymodynia, incontinence of urine, deficiency-cold of uterus, anemofrigid-damp arthralgia, soreness of waist and knee joint；Radix Serissae wind-dispelling, dampness removing, heat clearing away, removing toxic substances, dispelling the wind and dampness pathogens lumbago and skelalgia, dysentery, edema, conjunctival congestion and swelling pain, laryngalgia, toothache, women leucorrhea, carbuncle, scrofula；Herba Inulae cappae expelling wind and cold；Circulation of qi promoting dampness removing；Removing toxic substances and promoting subsidence of swelling；Main anemofrigid cold；Cough；Rheumatic arthralgia；Let out dysentery；Hepatitis；Mastitis；Hemorrhoid；Eczema；Scabies；Rhizoma Cynanchi Stauntonii sending down the abnormal ascending QI, expectorant, cough-relieving, stop up real, cough with copious phlegm, fullness in the chest dyspnea with rapid respiration for lung qi；The Fructus Perillae Frutescentiss therapeutic method to keep the adverse QI flowing downwards；Expectorant；Lung moistening；Wide intestinal；Main cough with dyspnea；Phlegm dyspnea；Stagnation of QI constipation；Huaihe River wood cures mainly gas on chronic cough, damaging the spleen and stomach weakness with emaciation, woman's erosion of the vulva, and whitish metrorrhagia crouches；Winged euonymus cures mainly woman's metrorrhagia hematochezia, abdominal distention sweating, evil removing, kills ghost poison tuberculous peritonitis, a terrible arrow；Resina Toxicodendri cures mainly exhausted wound, invigorating middle warmer, reuniting the fractured tendons and bones, fills out marrow brain, settling five organs, five slow six anxious, anemofrigid-damp arthralgia, Resina Toxicodendri verniciflui, goes snake, long term usage is made light of one's life by commiting suicide resistance to old；Soviet Union's core cures mainly trusted subordinate's pathogens agglomerating gas, improving eyesight, and conjunctival congestion with ophthalmalgia hinders lacrimation, and long term usage is made light of one's life by commiting suicide, and QI invigorating is not hungry
.
Beneficial effects of the present invention：One kind of the present invention
Cortex Jujubae relieving diarrhea with astringents bath effervescent tablets, to having loose bowels, dysentery, cough etc.
Main
Disease
Card serves to varying degrees
Relieving diarrhea with astringents, antitussive hemostasis, wind-dispelling
Effect,
There are health care, instant effect, pure natural, no side effectses.
The present invention uses the present invention through two groups of clinical verifications, one of which for treatment group, uses the present invention once daily, is within 7 days a course for the treatment of, and another group of matched group is taken
Rush down vertical stopping
, daily using once, being within 7 days a course for the treatment of, every group selection outpatient 110, wherein man 55, female 55, max age 81 years old, minimal ages 35 years old, clinical manifestation is to have loose bowels, dysentery, cough, metrorrhagia, traumatic hemorrhage, burn and scald
, table one is the contrasting data after taking a course for the treatment of：
Table 1 is taken two groups of courses for the treatment of of before and after and is compared (unit:People)
There were significant differences for treatment group and matched group, it will thus be seen that present invention application clinically has significant curative effect.
Specific embodiment
Embodiment 1
A kind of Cortex Jujubae relieving diarrhea with astringents bath effervescent tablets and preparation method thereof, it is made up by following percentage by weight of raw material, Chinese medicine extract 20-35%, sour agent 10-20%, alkaline agent 10-20%, filler 30-50%, binding agent 1-10%, lubricant 1-10%, aromatic 0.1-1%；Raw materials by weight portion in described Chinese medicine extract, Cortex Jujubae 50-70 part, Radix Morindae Officinaliss 15-20 part, Radix Serissae 15-20 part, Herba Inulae cappae 8-12 part, Rhizoma Cynanchi Stauntonii 8-12 part, Fructus Perillae Frutescentiss 5-8 part, Huaihe River wood 5-8 part, winged euonymus 5-8 part, Resina Toxicodendri 5-8 part, Soviet Union's core 5-8 part.
In described Chinese medicine extract, raw material presses optimum weight number, 60 parts of Cortex Jujubae, 18 parts of Radix Morindae Officinaliss, 17 parts of Radix Serissae, 12 parts of Herba Inulae cappae, 10 parts of Rhizoma Cynanchi Stauntonii, 8 parts of Fructus Perillae Frutescentiss, 7 parts of Huaihe River wood, 6 parts of winged euonymus, 5 parts of Resina Toxicodendri, 5 parts of core of Soviet Union.
Described sour agent is citric acid or tartaric acid or citric acid or fumaric acid.
Described alkaline agent is sodium carbonate or sodium bicarbonate.
Described filler is Microcrystalline Cellulose, sucrose, Lactose, sodium chloride, the calcium sulfate mixing of one or more therein.
Described binding agent is starch slurry or Microcrystalline Cellulose.
Described lubricant is the mixing of one of magnesium stearate, sodium lauryl sulphate or two kinds.
Described a kind of Cortex Jujubae relieving diarrhea with astringents bath effervescent tablets and preparation method thereof, the mainly comprising the following steps of its preparation method：
Step 1, prepare Chinese medicine extract：
a
, by weight, the Cortex Jujubae of selection high-quality, Radix Morindae Officinaliss, Radix Serissae, Herba Inulae cappae, Rhizoma Cynanchi Stauntonii, Fructus Perillae Frutescentiss, Huaihe River wood, winged euonymus, Resina Toxicodendri, Soviet Union's core, clean and remove impurity, mix homogeneously after remove impurity, add water to cook three times, the water small fire adding 12-15 times for the first time decocts 90-120 minute, filters, and extracts filtrate, second plus 10-12 times of water moderate heat decocts 60-90 minute, filter, extract filtrate, the water big fire that third time adds 6-8 times decocts 30-45 minute, filter, extract filtrate, mix three filtrates, obtain mixed extract；
b
, mixed extract is concentrated, be dried using spray dryer after concentration, obtain solid mixed extract, pulverized 60-80 mesh sieve, and obtained solid particle；
Step 2, mixing：
a
, the solid particle obtaining in step 1 is divided into uniform two parts, choose sour agent, alkaline agent, filler, binding agent, carry out respectively pulverizing 60 mesh sieves；
b
, first part of solid particle add the sour agent after pulverizing, filler, binding agent; it is then placed in trough type mixing machine; open trough type mixing machine to mix 30 minutes, add the PVP K30 ethanol solution that concentration is 1%, soft material processed into trough type mixing machine; add to soft material moderate after; soft material is put in oscillating granulator, makes granule, 60 eye mesh screen on oscillating granulator; dry, obtain acid particles；
c
, second part
Solid particle adds the alkaline agent after pulverizing, filler, binding agent; it is then placed in trough type mixing machine; open trough type mixing machine to mix 30 minutes, add the PVP K30 ethanol solution that concentration is 1%, soft material processed into trough type mixing machine; add to soft material moderate after; soft material is put in oscillating granulator, makes granule, 60 eye mesh screen on oscillating granulator; dry, obtain alkali grain；
d
, by acid particles, alkali grain, lubricant, aromatic mixing, put into tabletting in automatic tableting press after fully mixing, aluminum-plastic packaged, obtain a kind of Cortex Jujubae relieving diarrhea with astringents bath effervescent tablets.
Claims (8)
1. a kind of Cortex Jujubae relieving diarrhea with astringents bath effervescent tablets it is characterised in that：It is made up by following percentage by weight of raw material, Chinese medicine extract 20-35%, sour agent 10-20%, alkaline agent 10-20%, filler 30-50%, binding agent 1-10%, lubricant 1-10%, aromatic 0.1-1%；Raw materials by weight portion in described Chinese medicine extract, Cortex Jujubae 50-70 part, Radix Morindae Officinaliss 15-20 part, Radix Serissae 15-20 part, Herba Inulae cappae 8-12 part, Rhizoma Cynanchi Stauntonii 8-12 part, Fructus Perillae Frutescentiss 5-8 part, Huaihe River wood 5-8 part, winged euonymus 5-8 part, Resina Toxicodendri 5-8 part, Soviet Union's core 5-8 part.
2. a kind of Cortex Jujubae relieving diarrhea with astringents bath effervescent tablets according to claim 1 it is characterised in that：In described Chinese medicine extract, raw material presses optimum weight number, 60 parts of Cortex Jujubae, 18 parts of Radix Morindae Officinaliss, 17 parts of Radix Serissae, 12 parts of Herba Inulae cappae, 10 parts of Rhizoma Cynanchi Stauntonii, 8 parts of Fructus Perillae Frutescentiss, 7 parts of Huaihe River wood, 6 parts of winged euonymus, 5 parts of Resina Toxicodendri, 5 parts of core of Soviet Union.
3. a kind of Cortex Jujubae relieving diarrhea with astringents bath effervescent tablets according to claim 1 it is characterised in that：Described sour agent is citric acid or tartaric acid or citric acid or fumaric acid.
4. a kind of Cortex Jujubae relieving diarrhea with astringents bath effervescent tablets according to claim 1 it is characterised in that：Described alkaline agent is sodium carbonate or sodium bicarbonate.
5. a kind of Cortex Jujubae relieving diarrhea with astringents bath effervescent tablets according to claim 1 it is characterised in that：Described filler is Microcrystalline Cellulose, sucrose, Lactose, sodium chloride, the calcium sulfate mixing of one or more therein.
6. a kind of Cortex Jujubae relieving diarrhea with astringents bath effervescent tablets according to claim 1 it is characterised in that：Described binding agent is starch slurry or Microcrystalline Cellulose.
7. a kind of Cortex Jujubae relieving diarrhea with astringents bath effervescent tablets according to claim 1 it is characterised in that：Described lubricant is the mixing of one of magnesium stearate, sodium lauryl sulphate or two kinds.
8. a kind of Cortex Jujubae relieving diarrhea with astringents bath effervescent tablets according to claim 1-7 and preparation method thereof it is characterised in that：The mainly comprising the following steps of its preparation method：
Step 1, prepare Chinese medicine extract：
A, by weight, the Cortex Jujubae of selection high-quality, Radix Morindae Officinaliss, Radix Serissae, Herba Inulae cappae, Rhizoma Cynanchi Stauntonii, Fructus Perillae Frutescentiss, Huaihe River wood, winged euonymus, Resina Toxicodendri, Soviet Union's core, clean and remove impurity, mix homogeneously after remove impurity, add water to cook three times, the water small fire adding 12-15 times for the first time decocts 90-120 minute, filters, and extracts filtrate, second plus 10-12 times of water moderate heat decocts 60-90 minute, filter, extract filtrate, the water big fire that third time adds 6-8 times decocts 30-45 minute, filter, extract filtrate, mix three filtrates, obtain mixed extract；
B, mixed extract is concentrated, be dried using spray dryer after concentration, obtain solid mixed extract, pulverized 60-80 mesh sieve, and obtained solid particle；
Step 2, mixing：
A, the solid particle obtaining in step 1 is divided into uniform two parts, chooses sour agent, alkaline agent, filler, binding agent, carry out respectively pulverizing 60 mesh sieves；
B, first part of solid particle add the sour agent after pulverizing, filler, binding agent; it is then placed in trough type mixing machine; open trough type mixing machine to mix 30 minutes, add the PVP K30 ethanol solution that concentration is 1%, soft material processed into trough type mixing machine; add to soft material moderate after; soft material is put in oscillating granulator, makes granule, 60 eye mesh screen on oscillating granulator; dry, obtain acid particles；
C, second part of solid particle add the alkaline agent after pulverizing, filler, binding agent; it is then placed in trough type mixing machine; open trough type mixing machine to mix 30 minutes, add the PVP K30 ethanol solution that concentration is 1%, soft material processed into trough type mixing machine; add to soft material moderate after; soft material is put in oscillating granulator, makes granule, 60 eye mesh screen on oscillating granulator; dry, obtain alkali grain；
D, by acid particles, alkali grain, lubricant, aromatic mixing, put into tabletting in automatic tableting press after fully mixing, aluminum-plastic packaged, obtain a kind of Cortex Jujubae relieving diarrhea with astringents bath effervescent tablets.
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| CN201510513525.XA CN106466356A (en) | 2015-08-20 | 2015-08-20 | A kind of Cortex Jujubae relieving diarrhea with astringents bath effervescent tablets and preparation method thereof |
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