CN106418553A - 一种乳丙种球蛋白免疫胶囊及其制备方法 - Google Patents
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Abstract
本发明公开了一种乳丙种球蛋白免疫胶囊及其制备方法，乳丙种球蛋白免疫胶囊包括胶囊外壳以及内容物，内容物包括以下重量份的原料：乳丙种球蛋白 30‑60；α‑乳白蛋白10‑30；维生素C 20‑40；维生素A 0.5‑2；绞股蓝2‑5；炙甘草粉 1‑5；大豆色拉油70‑120。本发明产品整洁美观，容易吞服，色泽均匀，无明显气泡，且添加了天然活性成分，对提高免疫力十分有效。
Description
技术领域
本发明涉及一种乳丙种球蛋白免疫胶囊及其制备方法，属于药品及保健品领域。
背景技术
免疫力是人体自身的防御机制，是人体识别和消灭外来侵入的任何异物（病毒、细菌等），处理衰老、损伤、死亡、变性的自身细胞以及识别和处理体内突变细胞和病毒感染细胞的能力。现代免疫学认为，免疫力是人体识别和排除“异己”的生理反应。人体内执行这一功能的是免疫***。
免疫力低下的身体易于被感染或患癌症；免疫力超常也会产生对身体有害的结果，如引发过敏反应、自身免疫疾病等。
各种原因使免疫***不能正常发挥保护作用，在此情况下，极易招致细菌、病毒、真菌等感染，因此免疫力低下最直接的表现就是容易生病。因经常患病，加重了机体的消耗，所以一般有体质虚弱、营养不良、精神萎靡、疲乏无力、食欲降低、睡眠障碍等表现，生病、***吃药便成了家常便饭。每次生病都要很长时间才能恢复，而且常常反复发作。长此以往会导致身体和智力发育不良，还易诱发重大疾病。
丙种球蛋白含有健康人群血清所具有的各种抗体，与细菌、病毒和毒素结合，使之丧失致病功能，对炎症、肿瘤等有治疗、抑制作用，因而有增强机体抵抗力以预防感染的作用。
α-乳白蛋白是必需氨基酸和支链氨基酸的极好来源，也是唯一能与金属元素和钙元素结合的乳清蛋白成分。最近的研究更发现，它可能具有抗癌功能。此外乳白蛋白在氨基酸比例结构方面，以及在功能特性上与人乳都非常相似的。能提高免疫力，减少疾病发生。更好消化吸收，减轻肾脏负担。促进钙吸收，提升补钙效果。含有丰富色氨酸（快乐因子），睡眠、情绪更好，增进食欲。
目前还未有以丙种球蛋白和α-乳白蛋白作为主要原料来制备提高免疫力药物的报道。
发明内容
本发明涉及一种乳丙种球蛋白免疫胶囊及其制备方法，其能够大大提高人体的免疫力。
本发明技术方案是：
一种乳丙种球蛋白免疫胶囊，包括胶囊外壳以及内容物，所述内容物包括以下重量份的原料：
乳丙种球蛋白 30-60
α-乳白蛋白 10-30
维生素C 20-40
维生素A 0.5-2
绞股蓝 2-5
炙甘草粉 1-5
大豆色拉油 70-120
进一步优选为，所述内容物包括以下重量份的原料：
乳丙种球蛋白 30-60
α-乳白蛋白 10-30
维生素C 20-40
维生素A 0.5-2
绞股蓝 2-5
炙甘草粉 1-5
大豆色拉油 70-120
上述乳丙种球蛋白免疫胶囊的制备方法，包括以下步骤：
a) 配料：取乳丙种球蛋白、α-乳白蛋白、绞股蓝、炙甘草粉、维生素C、维生素A、大豆色拉油混合均匀得到内容物。
b）溶胶：取明胶加入适量水充分溶胀得到明胶液；将水与甘油混合，于水浴中加热至60-80℃，然后加入上述明胶液，搅拌使其混合均匀制成胶浆；其中明胶为150-200重量份，甘油为50-80重量份，明胶中加入的水和甘油中加入的水总共为150-200重量份；
c）制丸：将胶浆和内容物放入胶囊机制成胶囊；
d）洗涤：用乙醇洗去润滑油；
e）干燥：烘干，成丸。
进一步优选的，所述步骤b）中搅拌时间为1-1.5h。
进一步优选的，所述步骤d）中的乙醇为95%的乙醇。
进一步优选的，所述步骤e）中烘干温度为30-35℃。
有益效果
本发明产品整洁美观，容易吞服，色泽均匀，无明显气泡，且添加了天然活性成分，对提高免疫力十分有效。
具体实施方式
以下结合具体实施例对本发明做进一步的说明。
实施例1
将乳丙种球蛋白30kg、α-乳白蛋白15kg、 维生素C 20kg、维生素A 0.5kg、绞股蓝2kg、炙甘草粉1kg、大豆色拉油70kg搅拌均匀，脱泡，最后灌装制成胶囊，胶囊每粒500mg。
实施例2
将乳丙种球蛋白45kg、α-乳白蛋白20kg、 维生素C25kg、维生素A1kg、绞股蓝4kg、炙甘草粉3kg、大豆色拉油 80kg搅拌均匀，脱泡，最后灌装制成软胶囊，胶囊每粒500mg。
实施例3
将乳丙种球蛋白50kg、α-乳白蛋白22kg、 维生素C28kg、维生素A1kg、绞股蓝4kg、炙甘草粉3kg、大豆色拉油90kg搅拌均匀，脱泡，最后灌装制成胶囊，胶囊每粒500mg。
毒性试验
本实验采用健康 SD 大鼠 ，口服给药实施例 1-3制备的药物剂量梯度均为 0.01g/kg以及0.1g/kg，连续给药30天，经观察大鼠给药期间及停药后1周之内动物生长状态、活动饮食、血液学、血液生化学、脏器组织结构以及尿常规等均无明显影响，表明临床用药安全可靠。
试用结果：
在具体实施操作中，邀约80名经常情绪烦躁，精神焦虑，感冒反复发作，工作不起劲，经常感觉累的亚健康人群分组实验。结果见表一
| 组别 项目 | 例数（人） | 周期（天） | 总有效率（％） |
| 对照组 | 20 | 30 | 0 |
| 实施例1 | 20 | 30 | 90 |
| 实施例2 | 20 | 30 | 95 |
| 实施例3 | 20 | 30 | 98 |
由上表一可得，连续试吃实施例1-3免疫胶囊一个月后，相比较对照组（不吃免疫胶囊），实施例 1，2 , 3 组的总有效率显著提高。表明本发明乳丙种球蛋白免疫胶囊具有显著的提高免疫力效果。
Claims (6)
1.一种乳丙种球蛋白免疫胶囊，其特征在于，包括胶囊外壳以及内容物，所述内容物包括以下重量份的原料：
乳丙种球蛋白 30-60
α-乳白蛋白 10-30
维生素C 20-40
维生素A 0.5-2
绞股蓝 2-5
炙甘草粉 1-5
大豆色拉油 70-120。
2.根据权利要求1所述的乳丙种球蛋白免疫胶囊，其特征在于，所述内容物包括以下重量份的原料：
乳丙种球蛋白 30-60
α-乳白蛋白 10-30
维生素C 20-40
维生素A 0.5-2
绞股蓝 2-5
炙甘草粉 1-5
大豆色拉油 70-120。
3.权利要求1或2所述的乳丙种球蛋白免疫胶囊的制备方法，其特征在于，包括以下步骤：
a) 配料：取乳丙种球蛋白、α-乳白蛋白、绞股蓝、炙甘草粉、维生素C、维生素A、大豆色拉油混合均匀，真空脱泡得到内容物；
b）溶胶：取明胶加入适量水充分溶胀得到明胶液；将水与甘油混合，于水浴中加热至60-80℃，然后加入上述明胶液，搅拌使其混合均匀制成胶浆；其中明胶为150-200重量份，甘油为50-80重量份，明胶中加入的水和甘油中加入的水总共为150-200重量份；
c）制丸：将胶浆和内容物放入胶囊机制成胶囊；
d）洗涤：用乙醇洗去润滑油；
e）干燥：烘干，成丸。
4.根据权利要求3所述的乳丙种球蛋白免疫胶囊的制备方法，其特征在于，所述步骤b）中搅拌时间为1-1.5h。
5.根据权利要求3所述的乳丙种球蛋白免疫胶囊的制备方法，其特征在于，所述步骤d）中的乙醇为95%的乙醇。
6.根据权利要求3所述的乳丙种球蛋白免疫胶囊的制备方法，其特征在于，所述步骤e）中烘干温度为30-35℃。
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