CN106723022A - 一种梅花鹿茸蝙蝠蛾拟青霉菌胶囊及其制备方法 - Google Patents
一种梅花鹿茸蝙蝠蛾拟青霉菌胶囊及其制备方法 Download PDFInfo
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- A—HUMAN NECESSITIES
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- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
本发明公开了一种梅花鹿茸蝙蝠蛾拟青霉菌胶囊及其制备方法,梅花鹿茸蝙蝠蛾拟青霉菌胶囊各组份以质量份计分别如下:梅花鹿茸粉10~18份,蝙蝠蛾拟青霉菌粉40份,当归提取物12份,枸杞子提取物13份,硬脂酸镁1份。制备方法如下(1)过筛、称量;(2)混合;(3)制软材;(4)制粒;(5)干燥;(6)整粒;(7)总混;(8)胶囊填充;(9)抛光;(10)挑选、包装。本发明梅花鹿茸蝙蝠蛾拟青霉菌胶囊亦称“连天射胶囊”,是一种保健品,具有增强免疫力之功效;服用方便。其制备方法从过筛、称量直至内包装均在30万级洁净车间内进行,科学合理,卫生可靠。
Description
技术领域
本发明属于保健品制备技术领域,特别是涉及一种梅花鹿茸蝙蝠蛾拟青霉菌胶囊及其制备方法。
背景技术
梅花鹿茸,又名黄毛茸、花茸,为梅花鹿的头茬二杠幼角。梅花鹿茸含有比人参更丰富的氨基酸,包括甘氨酸(glycine)、赖氨酸(lysine)、精氨酸(arginine)、天冬氨酸(asparticacid)、谷氨酸(glutamicacid)、脯氨酸(proine)、丙氨酸(alanine)、亮氨酸(leucine)等17种以上,总氨基酸含量达50%以上;梅花鹿茸也富含卵磷脂、维生素和微量元素等。鹿茸的保健作用非常高,是良好的全身强壮药。鹿茸性温而不燥,具有振奋和提高机体功能,对全身虚弱、久病之后患者,有较好的保健作用。鹿茸可以提高机体的细胞免疫和体液免疫功能,促进淋巴细胞的转化,具有免疫促进剂的作用。它能增加机体对外界的防御能力,调节体内的免疫平衡而避免疾病发生和促进创伤愈合、病体康复,从而起到强壮身体、抵抗衰老的作用。
另外,梅花鹿茸具有多方面的药理作用,包括:
(1)对神经***的影响:鹿茸能增强副交感神经末梢的紧张性,促进恢复神经***和改善神经、肌肉***之功能,同时对交感神经亦有兴奋作用。
(2)对心血管***的影响:剂量的鹿茸可降低血压,使心脏收缩振幅变小,心率减慢,外周血管扩张。中等剂量能引起心脏收缩显著增强,收缩幅度变大,心率加快,从而使心输出量增加;鹿茸特别对已疲劳的心脏作用尤为显著。
(3)对性功能的影响:鹿茸提取物既能增加血浆睾酮浓度,又能使促***(LH)浓度增加。因此,鹿茸对***的性功能障碍,壮老年期的***萎缩症的治疗均有效;对治疗女性更年期障碍效果良好。
(4)鹿茸的强壮作用:鹿茸精具有较强的抗疲劳作用,能增强耐寒能力,加速创伤愈合和刺激肾上腺皮质功能。故鹿茸是传统的补益药,用于强壮、补肾、益阳。
(5)对血液成分的影响:鹿茸可使血液中血红蛋白增加,因此对于大量出血者和感染症末期的患者,特别是对于老龄患者的治疗极为有效。
(6)有性激素样作用:动物试验证实,用鹿茸酊作皮下注射,几天后即见***、精囊重量增加。
(7)它能兴奋离体肠管及子宫,增强肾脏的利尿功能。鹿茸对妇女儿童均有益处,它所含的钙、磷、镁等无机元素分别参与身体的钙磷和多种酶的代谢,对促进钙的吸收、骨的生长以及增强心脏、肌肉的功能都有积极的作用。尤其是镁离子,更是具有复杂的功能,是延年益寿必不可少的物质。这对妇女因宫寒不育、***,小儿的发育不良,因肾气不足而引起的牙齿生长迟缓、囟门不合、骨软等,均有较好的治疗作用。
(8)其他作用:鹿茸中有些有效成分能抑制MAO-B的活性,故有抗衰老作用;鹿茸具有抗氧化作用,增强胃肠蠕动和促进分泌功能;此外,鹿茸精还能增强机体的免疫功能等。
蝙蝠蛾拟青霉菌粉是天然冬虫夏草在制药业和食品工业上的替代品。从天然冬虫夏草分离得到虫草菌丝,经发酵培养,所得菌丝体的作用与天然冬虫夏草基本相同。虫草菌丝体粉学名蝙蝠蛾拟青霉菌粉,富含腺苷、多糖等活性物质,不仅含量丰富且比例适当,有效增强人体体质,全面提高了免疫机能和抗疲劳能力。蝙蝠蛾拟青霉菌粉中含有HH2,是女性生物钟的重要成分;可促使人体的抗体分泌量增加,可激活机体的免疫活性细胞,尤其对淋巴细胞转化和巨噬细胞吞噬率有明显促进作用。蝙蝠蛾拟青霉菌粉与冬虫夏草的药理作用基本相同,能够提高肝组织SOD的含量,抑制脂质过氧化物LPO的生成,对于高脂血症、性功能低下和慢性支气管炎等病也有一定疗效。
当归具有补血和血,调经止痛,润燥滑肠、抗癌、抗老防老、免疫之功效。
枸杞子含有丰富的胡萝卜素、多种维生素和钙、铁等健康眼睛的必需营养物质,故有明目之功,俗称“明眼子”。历代医家治疗肝血不足、肾阴亏虚引起的视物昏化和夜盲症,常常使用枸杞子。
但是目前的梅花鹿茸、蝙蝠蛾拟青霉菌存在着食用不便,有效成分被人体的吸收利用率低,效果不显著等问题,如何服用梅花鹿茸、蝙蝠蛾拟青霉菌,提高梅花鹿茸和蝙蝠蛾拟青霉菌的功效,一直来没有一种行之有效的方法。因此若能充分利用梅花鹿茸、蝙蝠蛾拟青霉菌的药用功效,开发出一种以以梅花鹿茸粉、蝙蝠蛾拟青霉菌粉为主要原料,服用方便、使用效果更为显著的保健产品,无疑具有极大的市场价值。本发明人多年来潜心研究梅花鹿茸和蝙蝠蛾拟青霉菌的服用办法,以期提高其功效。
发明内容
本发明的目的在于提供一种梅花鹿茸蝙蝠蛾拟青霉菌胶囊,以方便梅花鹿茸、蝙蝠蛾拟青霉菌的食用,并能提高梅花鹿茸和蝙蝠蛾拟青霉菌的功效。本发明同时提出了一种梅花鹿茸蝙蝠蛾拟青霉菌胶囊的制备方法。
本发明解决技术问题所采取的技术方案是:
第一个方面,一种梅花鹿茸蝙蝠蛾拟青霉菌胶囊,以梅花鹿茸粉、蝙蝠蛾拟青霉菌粉、当归提取物和枸杞子提取物为原料,以硬脂酸镁为辅料,各组份以质量份计分别如下:
梅花鹿茸粉 10~18份,
蝙蝠蛾拟青霉菌粉 40份,
当归提取物 12份,
枸杞子提取物 13份,
硬脂酸镁 1份。
所述梅花鹿茸蝙蝠蛾拟青霉菌胶囊中的标志性成分腺苷≥0.70%。
第二个方面,一种如第一个方面所述的梅花鹿茸蝙蝠蛾拟青霉菌胶囊的制备方法,包括以下步骤:
(1)过筛、称量:取梅花鹿茸粉、蝙蝠蛾拟青霉菌粉、当归提取物、枸杞子提取物和硬脂酸镁分别过80目筛后称量备用;75%食用酒精备用;
(2)混合:将称量好的梅花鹿茸冻干粉、蝙蝠蛾拟青霉菌粉、当归提取物和枸杞子提取物进行混合,时间15-20min,得到混合粉;
(3)制软材:将75%食用酒精均匀喷洒于混合粉中,以“手轻握成团,捏之即散”为宜;
(4)制粒:将制好的软材过20目筛制粒;
(5)干燥:温度50-60℃,水分控制在≤5%;
(6)整粒:过20目筛整粒;
(7)总混:取称量好的硬脂酸镁与上述颗粒进行混合,时间15~20min,得到混合物;
(8)胶囊填充:将总混所得混合物装入胶囊填充机,控制装量差异在±7.0%;
(9)抛光:将充填好的胶囊用抛光机抛光;
(10)挑选、包装:挑选剔除瘪囊、破囊、空壳和/或漏粉的不合格品;采用口服固体药用高密度聚乙烯瓶进行包装。
生产环境为30万级洁净车间。
称量时,各组份以质量份计分别如下:
梅花鹿茸粉 10~18份,
蝙蝠蛾拟青霉菌粉 40份,
当归提取物 12份,
枸杞子提取物 13份,
硬脂酸镁 1份。
本发明梅花鹿茸蝙蝠蛾拟青霉菌胶囊亦称“连天射胶囊”,是一种保健品,具有增强免疫力之功效;服用方便。其制备方法从过筛、称量直至内包装均在30万级洁净车间内进行,科学合理,卫生可靠。
具体实施方式
下面通过具体实施例对本发明做进一步的描述。
实施例1:
一种梅花鹿茸蝙蝠蛾拟青霉菌胶囊。以梅花鹿茸冻干粉、蝙蝠蛾拟青霉菌粉、当归提取物和枸杞子提取物为原料,以硬脂酸镁为辅料,每粒胶囊内含400mg,其中:
梅花鹿茸冻干粉 70 mg,
蝙蝠蛾拟青霉菌粉 200 mg,
当归提取物 60 mg,
枸杞子提取物 65 mg,
硬脂酸镁 5 mg。
实施例2:
一种梅花鹿茸蝙蝠蛾拟青霉菌胶囊的制备方法。在30万级洁净车间内进行,包括以下步骤:
(1)过筛、称量:取梅花鹿茸冻干粉、蝙蝠蛾拟青霉菌粉、当归提取物、枸杞子提取物和硬脂酸镁分别过80目筛后称量备用;75%食用酒精备用;称量时,各组份以质量份计分别如下:
梅花鹿茸冻干粉 14份,
蝙蝠蛾拟青霉菌粉 40份,
当归提取物 12份,
枸杞子提取物 13份,
硬脂酸镁 1份;
(2)混合:将称量好的梅花鹿茸冻干粉、蝙蝠蛾拟青霉菌粉、当归提取物和枸杞子提取物进行混合,时间15-20min,得到混合粉;
(3)制软材:将75%食用酒精均匀喷洒于混合粉中,以“手轻握成团,捏之即散”为宜;
(4)制粒:将制好的软材过20目筛制粒;
(5)干燥:温度50-60℃,水分控制在≤5%;
(6)整粒:过20目筛整粒;
(7)总混:取称量好的硬脂酸镁与上述颗粒进行混合,时间15-20min,得到混合物;
(8)胶囊填充:将总混所得混合物装入胶囊填充机,每粒装入混合物400mg,控制装量差异在±7.0%;
(9)抛光:将充填好的胶囊用抛光机抛光;
(10)挑选、包装:挑选剔除瘪囊、破囊、空壳和/或漏粉的不合格品;采用口服固体药用高密度聚乙烯瓶进行包装。
制备梅花鹿茸蝙蝠蛾拟青霉菌胶囊的原辅料的质量要求如下:
a.梅花鹿茸粉
感官:浅棕色粉末,本品特有的滋味,气味;
水分≤10%;
灰分≤10%;
菌落总数≤1000CFU/g;
大肠菌群≤40MPN/100g;
霉菌≤25CFU/g;
酵母菌≤25CFU/g;
致病菌(沙门氏菌、志贺氏菌、金黄色葡萄球菌、溶血性链球菌):不得检出。
b.蝙蝠蛾拟青霉菌粉
感官:棕色粉末,本品特有的滋味,气味;
腺苷≥0.22%;
水分≤10%;
灰分≤10%;
菌落总数≤1000CFU/g;
大肠菌群≤40MPN/100g;
霉菌≤25CFU/g;
酵母菌≤25CFU/g;
致病菌(沙门氏菌、志贺氏菌、金黄色葡萄球菌、溶血性链球菌):不得检出。
c.当归提取物
感官:棕色粉末,本品特有的滋味、气味;
水分≤10%;
灰分≤10%;
铅(以Pb计)≤0.5mg/kg;
砷(以As计)≤0.3mg/kg;
汞(以Hg计)≤0.1mg/kg;
六六六≤0.2mg/kg;
滴滴涕≤0.2mg/kg;
菌落总数≤1000CFU/g;
大肠菌群≤40MPN/100g;
霉菌≤25CFU/g;
酵母菌≤25CFU/g;
致病菌(沙门氏菌、志贺氏菌、金黄色葡萄球菌、溶血性链球菌):不得检出。
d.枸杞子提取物
感官:棕色粉末,本品特有的滋味、气味;
水分≤10%;
灰分≤10%;
铅(以Pb计)≤0.5mg/kg;
砷(以As计)≤0.3mg/kg;
汞(以Hg计)≤0.1mg/kg;
六六六≤0.2mg/kg;
滴滴涕≤0.2mg/kg;
菌落总数≤1000CFU/g;
大肠菌群≤40MPN/100g;
霉菌≤25CFU/g;
酵母菌≤25CFU/g;
致病菌(沙门氏菌、志贺氏菌、金黄色葡萄球菌、溶血性链球菌):不得检出。
由上述方法制得的梅花鹿茸蝙蝠蛾拟青霉菌胶囊,经测试符合下列质量指标:
a.感官要求符合下列规定:
色泽:浅棕色;
滋味、气味:具有本品固有的滋味、气味,无异味;
性状:硬胶囊,内容物为粉末;
杂质:无肉眼可见外来杂质。
b.保健功能:增强免疫力。
c.标志性成分:腺苷≥0.70g/100g。
d.理化指标符合下列规定:
水分≤9.0%;
灰分≤10.0%;
崩解时限≤60min;
铅(以Pb计)≤1.5mg/kg;
砷(以As计)≤1.0mg/kg;
汞(以Hg计)≤0.3mg/kg;
六六六≤0.2mg/kg;
滴滴涕≤0.2mg/kg。
e.微生物学指标符合下列规定:
菌落总数≤1000CFU/g;
大肠菌群≤40MPN/100g;
霉菌≤25CFU/g;
酵母菌≤25CFU/g;
致病菌(指沙门氏菌、志贺氏菌、金黄色葡萄球菌、溶血性链球菌):不得检出。
Claims (3)
1.一种梅花鹿茸蝙蝠蛾拟青霉菌胶囊,其特征在于,以梅花鹿茸粉、蝙蝠蛾拟青霉菌粉、当归提取物和枸杞子提取物为原料,以硬脂酸镁为辅料,各组份以质量份计分别如下:
梅花鹿茸粉 10~18份,
蝙蝠蛾拟青霉菌粉 40份,
当归提取物 12份,
枸杞子提取物 13份,
硬脂酸镁 1份。
2.如权利要求1所述的梅花鹿茸蝙蝠蛾拟青霉菌胶囊,其特征在于,其中标志性成分腺苷≥0.70%。
3.一种如权利要求1所述的梅花鹿茸蝙蝠蛾拟青霉菌胶囊的制备方法,其特征在于,包括以下步骤:
(1)过筛、称量:取梅花鹿茸粉、蝙蝠蛾拟青霉菌粉、当归提取物、枸杞子提取物和硬脂酸镁分别过80目筛后称量备用;75%食用酒精备用;
(2)混合:将称量好的梅花鹿茸粉、蝙蝠蛾拟青霉菌粉、当归提取物和枸杞子提取物进行混合,时间15-20min,得到混合粉;
(3)制软材:将75%食用酒精均匀喷洒于混合粉中,以“手轻握成团,捏之即散”为宜;
(4)制粒:将制好的软材过20目筛制粒;
(5)干燥:温度50-60℃,水分控制在≤5%;
(6)整粒:过20目筛整粒;
(7)总混:取称量好的硬脂酸镁与上述颗粒进行混合,时间15~20min,得到混合物;
(8)胶囊填充:将总混所得混合物装入胶囊填充机,控制装量差异在±7.0%;
(9)抛光:将充填好的胶囊用抛光机抛光;
(10)挑选、包装:挑选剔除瘪囊、破囊、空壳和/或漏粉的不合格品;采用口服固体药用高密度聚乙烯瓶进行包装。
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