CN106389720A - 一种治疗强直性脊柱炎的药物及其制备方法 - Google Patents
一种治疗强直性脊柱炎的药物及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种治疗强直性脊柱炎的药物及其制备方法,其主要是由桂枝、防风、伸筋草、透骨草、五加皮、川乌头按一定重量配比制备而成,本发明药物具有祛风活血、散寒止痛、通经去瘀的功能,用于治疗强直性脊柱炎见效快、疗效好,无副作用。
Description
技术领域
本发明涉及一种治疗强直性脊柱炎的药物及其制备方法,属中药领域。
背景技术
强直性脊柱炎是以骶髂关节和脊柱附着点炎症为主要症状的疾病,是四肢大关节,以及椎间盘纤维环及其附近***纤维化和骨化,以关节强直为病变特点的慢性炎性疾病。由于西药无法有效快速治疗强直性脊柱炎,因此人们对快速有效治疗强直性脊柱炎的中药药物存在极大的需求,至今为止,还没有发现关于本发明的有关报道。
发明内容
本发明人依据中医理论的研究和临床试验的反复验证,终于找到了有效治疗强直性脊柱炎的药物,从而完成了本发明。
本发明的目的就是提供一种更有效的治疗强直性脊柱炎的中药组合药物。
本发明的另一目的就是提供了该中药组合药物的制备方法。
本发明药物是选择桂枝、防风、伸筋草、透骨草、五加皮、川乌头、草乌头、红花、川芎、川牛膝、防己、黄芪、鸡血藤、秦艽、寻骨风、丹参、海风藤、续断、骨碎补、乳香、没药、蜈蚣、马钱子、千年健、蚂蚁、苍术、蚯蚓进行组合制备的,将这些药物组合使得各药物功效产生协同作用,从而能够有效治疗强直性脊柱炎。其中选用桂枝是因为其性味辛甘,温,入膀胱、心、肺经,有发汗解肌,温经通脉的功能,治风寒表证,肩背肢节酸疼,胸痹痰饮,经闭癥瘕。选用防风是因为其性味辛甘,温,入膀胱、肺、脾经,有发表,祛风,胜湿,止痛的功能,治外感风寒,头痛,目眩,项强,风寒湿痹,骨节酸痛,四肢挛急,破伤风。选用伸筋草是因为其性味苦辛,温,入肝、胃、肾三经,有祛风散寒,除湿消肿,舒筋活血的功能,治风寒湿痹,关节酸痛,皮肤麻木,四肢软弱,水肿,跌打损伤。选用透骨草是因为其性味辛温,有祛风,除湿,舒筋,活血,止痛的功能,治风湿痹痛,筋骨挛缩,疮癣肿毒。选用五加皮是因为其性味辛,温,入肝、肾经,有祛风湿,壮筋骨,活血去瘀的功能,治风寒湿痹,筋骨挛急,腰痛,阳痿,脚弱,小儿行迟、水肿,脚气,疮疽肿毒,跌打劳伤。选用川乌头,异名川乌,其性味辛,热,有毒,入脾、命门二经,有祛寒湿,散风邪,温经,止痛的功能,治风寒湿痹,历节风痛,四肢拘挛,半身不遂,头风头痛,心腹冷痛,阴疽肿毒。选用草乌头,异名草乌,其性味辛,热,有毒,入肝、脾、肺经,有搜风胜湿,散寒止痛,开痰,消肿的功能,治风寒湿痹,中风瘫痪,破伤风,头风,脘腹冷痛,痰癖,气块,冷痢,喉痹,痈疽,疔疮,瘰疬。选用红花是因为其性味辛,温,入心、肝经,有活血通经,去瘀止痛的功能,治经闭,癥瘕,难产,死胎,产后恶露不行,瘀血作痛,痈肿,跌扑损伤。选用川芎是因为其性味辛,温,入肝、胆经,有行气开郁,祛风燥湿,活血止痛的功能,治风冷头痛旋晕,胁痛腹疼,寒痹筋挛,经闭,难产,产后瘀阻块痛,痈疽疮疡。选用川牛膝是因为其性味平,味苦微苦,无毒,入肝、肾二经,有祛风,利湿,通经,活血的功能,治风湿腰膝疼痛,脚痿筋挛,血淋,尿血,妇女经闭,癥瘕。选用防己是因为其性味苦,寒,入膀膛、脾、肾经,有行水,泻下焦湿热的功能,治水肿臌胀,湿热脚气,手足挛痛,癣疥疮肿。选用黄芪是因为其性味甘,微温,入肺、脾经,生用有益卫固表,利水消肿,托毒,生肌的功能,治自汗,盗汗,血痹,浮肿,痈疽不溃或溃久敛;炙用有补中益气的功能,治内伤劳倦,脾虚泄泻,脱肛,气虚血脱,崩带及一切气衰血虚之症。选用鸡血藤是因为其性味苦甘,温,入心、脾二经,有活血、舒筋的功能,治腰膝酸痛,麻木瘫痪,***。选用秦艽是因为其性味苦辛,平,入肝、胃、胆经,有祛风除湿,和血舒筋,清热利尿的功能,治风湿痹痛,筋骨拘挛,黄疸,便血,骨蒸潮热,小儿疳热,小便不利。选用寻骨风是因为其性味苦,平,治风湿关节痛,腹痛,疟疾,痈肿。选用丹参是因为其性味苦,微温,入心、肝经,有活血去瘀,安神宁心,排脓,止痛的功能,治心绞痛,***,痛经,以闭,血崩带下,癥瘕,积聚,瘀血腹痛,骨节疼痛,惊悸不眠,恶疮肿毒。选用海风藤是因为其性味辛苦,微温,入心、肾二经,有祛风湿,通经络,理气的功能,治风寒湿痹,关节疼痛,筋脉拘挛,跌打损伤,哮喘,久咳。选用续断是因为其性味苦辛,微温,入肝、肾经,有补肝肾,续筋骨,调血脉的功能,治腰背酸痛,足膝无力,胎漏,崩漏,带下,遗精,跌打损伤,金疮,痔漏,痈疽疮肿。选用骨碎补是因为其性味苦,温,入肝、肾经,有补肾,活血,止血的功能,治肾虚久泻及腰痛,风湿痹痛,齿痛,耳鸣,跌打闪挫、骨伤,阑尾炎,斑秃,鸡眼。选用乳香是因为其性味辛苦,温,入心、肝、脾经,有调气活血,定痛,追毒的功能,治气血凝滞,心腹疼痛,痈疮肿毒,跌打损伤,痛经,产后瘀血刺痛。选用没药是因为其性味苦,平,入肝经,有散血去瘀,消肿定痛的功能,治跌损,金疮,筋骨,心腹诸痛,癥瘕,经闭,痈疽肿痛,痔漏,目障。选用蜈蚣是因为其性味辛,温,有毒,入肝经,有祛风,定惊,攻毒,散结的功能,治中风,惊癎,破伤风,百日咳,冀疬,结核,癥积瘤块,疮疡肿毒,风癣,白秃,痔漏,烫伤。选用马钱子是因为其性味苦,寒,有毒,有散血热,消肿,止痛的功能,治咽喉痹痛,痈疽肿毒,风痹疼痛,骨折,并治面神经麻痹,重症肌无力。选用千年健是因为其性味苦、辛,温,归肝、肾经,有祛风湿,健筋骨的功能,治风寒湿痹,腰膝冷痛,下肢拘挛麻木。选用蚂蚁是因为其性味咸酸,平,归肝、肾经,有补肾益精,舒筋活络,解毒消肿的功能,治风湿痹痛,中风偏瘫,手足麻木,硬皮病,皮肤炎,痈肿疔疮,毒蛇咬伤。选用苍术是因为其性味辛苦,温,入脾、胃经,有健脾,燥湿,解郁,辟秽的功能,治湿盛困脾,倦怠嗜卧,脘痞腹胀,食欲不振,呕吐,泄泻,痢疾,疟疾,痰饮,水肿,时气感冒,风寒湿痹,足痿,夜盲。选用蚯蚓是因为其性味咸,寒,入肝、脾、肺经,有清热,平肝,止喘,通络的功能,治高热狂躁,惊风抽搐,风热头痛,目赤,中风半身不遂,喘息,喉痹,关节疼痛,齿衄,小便不通,瘰疬,痄腮,疮疡。
具体实施方式
本发明组分的药物用量也是发明人经过大量摸索总结得出的,各组分的用量在下述重量范围内都具有较好的疗效:
桂枝70-100克,防风5-20克,伸筋草120-180克,透骨草20-40克,五加皮8-15克,川乌头8-15克,草乌头8-15克,红花8-15克,川芎8-15克,川牛膝15-30克,防己10-25克,黄芪40-70克,鸡血藤5-15克,秦艽8-18克,寻骨风8-15克,丹参5-16克,海风藤10-20克,续断15-25克,骨碎补8-15克,乳香8-15克,没药8-15克,蜈蚣6-12克,马钱子0.05-0.1克,千年健8-15克,蚂蚁10-18克,苍术8-15克,蚯蚓6-12克。
优选为:
桂枝90克,防风10克,伸筋草150克,透骨草30克,五加皮10克,川乌头10克,草乌头10克,红花10克,川芎10克,川牛膝20克,防己15克,黄芪60克,鸡血藤10克,秦艽10克,寻骨风10克,丹参10克,海风藤10克,续断20克,骨碎补10克,乳香10克,没药10克,蜈蚣10克,马钱子0.1克,千年健10克,蚂蚁15克,苍术10克,蚯蚓10克。
本发明药物的制备方法如下
一、备料
1、桂枝:用水稍浸泡,捞出,闷润至透,切片,晾干,筛去屑;
2、防风:除去残茎,用水浸泡,捞出,润透切片,晒干;
3、伸筋草:筛去灰屑,拣净杂质,切成小段;
4、透骨草:拣净杂质,切段;
5、五加皮:拣净杂质,用水洗净,稍润后,切片,干燥;
6、川乌头:拣净杂质,用水洗净,稍润后切片,干燥;
7、草乌头:取原药材,除去杂质,洗净,干燥,用时捣碎;
8、红花:拣净杂质,除去茎叶、蒂头,晒干;
9、川芎:拣去杂质,分开大、小个,用水浸泡,晒晾,闷润后切片,干燥;
10、川牛膝:拣去杂质,晾干;
11、防己:原药用水洗净,捞出润透,切片,晒干;
12、黄芪:拣净杂质,除去残留的根头和空心较大的根,用水浸泡,捞出,润透后及时切片,晒干;
13、鸡血藤:用水润透,切片,或蒸软后趁热切片,晒干
14、秦艽:拣去杂质,除去芦头,稍浸,润透切片,晒干;
15、寻骨风:5月开花前采收,晒干;
16、丹参:拣净杂质,除去根茎,洗净,捞出,润透后切片,晾干;
17、海风藤:原药放清水中浸30-60分钟,取出放箩内润16-24小时,切片,晒干;
18、续断:洗净泥沙,除去残留根头,润透后切片晒干,筛去屑;
19、骨碎补:去净泥砂杂质,洗净,稍浸泡,润透,切片,晒干;
20、乳香::拣去砂子杂质;
21、没药:拣去杂质,打成碎块;
22、蜈蚣:拭净,除去头足,剪断用;
23、马钱子:取原药材,除去杂质;
24、千年健:除去杂质,洗净,润透,切薄片,干燥,筛去碎屑;
25、蚂蚁:除去泥沙,杂质,置于60℃水中迅速处死,取出,晒干;
26、苍术:拣去杂质,用水泡至七、八成透,捞出,润透后切片,晒干;
27、蚯蚓:拣去杂质,用水漂净,及时捞出,晒干,切段。
二、制备
1、将炮制好的原料药物共同放入布袋中;
2、将装好药物的药袋放入自制的电加热锅中加水6斤,加盖浸泡;
3、浸泡5分钟后,启动电热锅电源进行加热;
4、加热至治疗温度42℃使药物产生雾化时,即得治疗强直性脊柱炎熏蒸的药物。
组方中透骨草有祛风,除湿,舒筋,活血,止痛的功能为君药;五加皮、伸筋草有祛风湿,壮筋骨,活血去瘀,祛风散寒,除湿消肿,舒筋活血的功能为臣药,三味药共同发挥祛湿舒筋,去瘀活血的作用,治疗强直性脊柱炎效力全面,且以除湿消肿,舒筋活血为主可治本;川乌头有祛寒湿,散风邪,温经,止痛的功能为佐药;红花有活血通经,去瘀止痛的功能为使药,与下余诸药是治标,本申请将上述药物组合,使得各药物功效产生协同作用,从而达到较好的疗效。
本发明药物具有祛风活血、散寒止痛、通经去瘀的功能,用于治疗强直性脊柱炎见效快,疗效好,无副作用。
以下通过试验例来进一步阐述本发明药物的有益效果,这些试验包括本发明药物临床疗效观察试验。
[试验例]本发明药物的临床疗效观察
1、一般资料
收治强直性脊柱炎门诊患者33例。
2、诊断标准
患者多有关节病变,且绝大多数首先侵犯骶髂关节,以后上行发展至颈椎。少数病人先由颈椎或几个脊柱段同时受侵犯,也可侵犯周围关节,早期病变处关节有炎性疼痛,伴有关节周围肌肉痉挛,有僵硬感,晨起明显。也可表现为夜间疼,经活动或服止痛剂缓解。随着病情发展,关节疼痛减轻,而各脊柱段及关节活动受限和畸形,晚期整个脊柱和下肢变成僵硬的弓形,向前屈曲。
3、治疗方法
将装有上述药物的药袋放入电加热锅中,加水6斤并加盖浸泡5分钟,加热至42℃治疗温度时,让患者仰卧在薰蒸床上,将患部挪至薰蒸锅中心开始从疼痛明显处薰蒸,温度控制在40-45℃,对患部薰蒸顺序依次为胸椎、腰椎、骶髂关节,每个***进行20分钟薰蒸,熏蒸2袋后,逐渐将薰蒸时间增加至30分钟、40分钟至60分钟,患者熏蒸需每日一次,每次30—60分钟,每个药袋薰蒸6次,6次后更换新药袋,20日为一个疗程,连续熏蒸四个疗程。
4、疗效评定标准
显效:强直性脊柱炎症状消失,恢复正常,随访一年无复发;
好转:强直性脊柱炎病变症状好转,僵硬感、疼痛减轻,患者症状得到改善,病情逐步好转;
无效:达不到好转标准者。
5、治疗结果(见下表):
在上述治疗中,用本发明药物治疗强直性脊柱炎患者33例,结果显效27例,显效率为81.82%,好转4例,好转率为12.12%,无效2例,总有效率为93.94%。
强直性脊柱炎是一种血清反应阴性,病因不明的常见关节疾病,是一种独立性、进行性、全身性疾病,由骶髂关节向上,髋关节、椎间关节、胸椎关节侵犯性发展性疾病,以侵犯中轴关节及四肢大关节为主,并波及其他关节及内脏,可造成人体畸形及残疾,故成为严重危害人类身体健康的疾病。本病多发生于10-40岁,高峰年龄为20-30岁,40岁以后发病者少见,男性较女性多见,早期常为人们忽视,诊断较迟。目前,尚无理想的治疗方法。服用西药、贴膏药、拨罐等只能缓解当时疼痛,远期病疾逐渐加重畸形,病因病机整体属正虚、肝虚、髓海不足,而最早有关痹证的证述见于我国最早的医学经典《黄帝内经》,在其《素问∙痹证》中对病因、病机和分类进行了论述,《素问∙长刺节论》曰:“病在骨,骨重不可举,骨髓酸痛,客气至,名曰骨痹。”《内经知要病能》曰:“强者,筋强。直者,体直而不能屈伸也。”关节强直多是由于风寒湿邪或湿热阻滞经脉,痹痛日久,筋内养而不能屈伸,督脉虚而精髓不充,则易受邪侵袭,阻滞经脉气血,致痰饮流流脊柱、关节,久积不去,则出现脊柱四肢关节僵直、变形而成大偻(大偻俗称为驼痛)。治疗当以祛风、散寒、除湿、化痰散结为原则。《内经》云:“在筋守筋,在骨守骨。”“痛生于筋骨,治之以薰引”,因本病病位在筋骨,故治法用中药薰蒸正合此理,运用中药气疗,通过药物薰蒸渗透到局部病变,使药物有效成分通过开泄的腠理,以湿热之力直达病所。此药袋内的药物有松解脊柱及骶髂关节粘连,补气补肾,温经通脉,使药效直达病灶,能较迅速有效地阻止关节的破坏,抑制骨反应,改善血液循环,消除炎症,解除脊柱关节刺激与粘连,达到消除疼痛,恢复脊柱关节的目的。经过此方药研究推理和现代医学研究亦证实,活血化瘀能有效抑制炎性细胞的浸润,促进毛细血管的开放与重建,加速炎症介质的吸收,消除水肿,改善血液循环与微循环,加上补肝肾,强筋骨,利关节的药物,又有温经散寒,消肿散结,再加气血双补的黄芪,可以推陈出新,血液循环更充足有力,消除组织代谢中的病理产物,以上方药通过薰蒸的温热作用,使脊柱关节周围组织温度升高,扩张血管,改善血循环,能使药力直达病所,使脊柱骶髂关节肌肉粘连痉挛解除,炎症水肿逐渐消失,脊柱骶髂关节功能恢复。
Claims (3)
1.一种治疗强直性脊柱炎的药物,其特征在于:它是由下列重量范围内的原料药制成:
桂枝70-100克,防风5-20克,伸筋草120-180克,透骨草20-40克,五加皮8-15克,川乌头8-15克,草乌头8-15克,红花8-15克,川芎8-15克,川牛膝15-30克,防己10-25克,黄芪40-70克,鸡血藤5-15克,秦艽8-18克,寻骨风8-15克,丹参5-16克,海风藤10-20克,续断15-25克,骨碎补8-15克,乳香8-15克,没药8-15克,蜈蚣6-12克,马钱子0.05-0.1克,千年健8-15克,蚂蚁10-18克,苍术8-15克,蚯蚓6-12克。
2.根据权利要求1所述的药物,其中各原料药的用量为:
桂枝90克,防风10克,伸筋草150克,透骨草30克,五加皮10克,川乌头10克,草乌头10克,红花10克,川芎10克,川牛膝20克,防己15克,黄芪60克,鸡血藤10克,秦艽10克,寻骨风10克,丹参10克,海风藤10克,续断20克,骨碎补10克,乳香10克,没药10克,蜈蚣10克,马钱子0.1克,千年健10克,蚂蚁15克,苍术10克,蚯蚓10克。
3.根据权利要求1或2所述药物的制备方法,它包括下列步骤:
(一)备料
(1)桂枝:用水稍浸泡,捞出,闷润至透,切片,晾干,筛去屑;
(2)防风:除去残茎,用水浸泡,捞出,润透切片,晒干;
(3)伸筋草:筛去灰屑,拣净杂质,切成小段;
(4)透骨草:拣净杂质,切段;
(5)五加皮:拣净杂质,用水洗净,稍润后,切片,干燥;
(6)川乌头:拣净杂质,用水洗净,稍润后切片,干燥;
(7)草乌头:取原药材,除去杂质,洗净,干燥,用时捣碎;
(8)红花:拣净杂质,除去茎叶、蒂头,晒干;
(9)川芎:拣去杂质,分开大、小个,用水浸泡,晒晾,闷润后切片,干燥;
(10)川牛膝:拣去杂质,晾干;
(11)防己:原药用水洗净,捞出润透,切片,晒干;
(12)黄芪:拣净杂质,除去残留的根头和空心较大的根,用水浸泡,捞出,润透后及时切片,晒干;
(13)鸡血藤:用水润透,切片,或蒸软后趁热切片,晒干
(14)秦艽:拣去杂质,除去芦头,稍浸,润透切片,晒干;
(15)寻骨风:5月开花前采收,晒干;
(16)丹参:拣净杂质,除去根茎,洗净,捞出,润透后切片,晾干;
(17)海风藤:原药放清水中浸30-60分钟,取出放箩内润16-24小时,切片,晒干;
(18)续断:洗净泥沙,除去残留根头,润透后切片晒干,筛去屑;
(19)骨碎补:去净泥砂杂质,洗净,稍浸泡,润透,切片,晒干;
(20)乳香::拣去砂子杂质;
(21)没药:拣去杂质,打成碎块;
(22)蜈蚣:拭净,除去头足,剪断用;
(23)马钱子:取原药材,除去杂质;
(24)千年健:除去杂质,洗净,润透,切薄片,干燥,筛去碎屑;
(25)蚂蚁:除去泥沙,杂质,置于60℃水中迅速处死,取出,晒干;
(26)苍术:拣去杂质,用水泡至七、八成透,捞出,润透后切片,晒干;
(27)蚯蚓:拣去杂质,用水漂净,及时捞出,晒干,切段;
(二)制备
(1)将炮制好的原料药物共同放入布袋中;
(2)将装好药物的药袋放入自制的电加热锅中加水6斤,加盖浸泡;
(3)浸泡5分钟后,启动电热锅电源进行加热;
(4)加热至治疗温度42℃使药物产生雾化时,即得治疗强直性脊柱炎熏蒸的药物。
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