CN106039220A - 一种治疗膝关节骨性关节炎的外用药物及其制备方法 - Google Patents
一种治疗膝关节骨性关节炎的外用药物及其制备方法 Download PDFInfo
- Publication number
- CN106039220A CN106039220A CN201610541986.2A CN201610541986A CN106039220A CN 106039220 A CN106039220 A CN 106039220A CN 201610541986 A CN201610541986 A CN 201610541986A CN 106039220 A CN106039220 A CN 106039220A
- Authority
- CN
- China
- Prior art keywords
- radix
- gram
- grams
- rhizoma
- pick
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/716—Clematis (leather flower)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/11—Pteridophyta or Filicophyta (ferns)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/11—Pteridophyta or Filicophyta (ferns)
- A61K36/12—Filicopsida or Pteridopsida
- A61K36/126—Drynaria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/237—Notopterygium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/238—Saposhnikovia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/286—Carthamus (distaff thistle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
- A61K36/324—Boswellia, e.g. frankincense
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
- A61K36/328—Commiphora, e.g. mecca myrrh or balm of Gilead
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/46—Eucommiaceae (Eucommia family), e.g. hardy rubber tree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/486—Millettia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/56—Loganiaceae (Logania family), e.g. trumpetflower or pinkroot
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/708—Rheum (rhubarb)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/714—Aconitum (monkshood)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/756—Phellodendron, e.g. corktree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/884—Alismataceae (Water-plantain family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
- A61K36/8994—Coix (Job's tears)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
本发明公开了一种治疗膝关节骨性关节炎的外用药物及其制备方法,其主要是由威灵仙、川乌头、草乌头、黄芪、透骨草、伸筋草、鸡血藤、防风按一定重量配比制备而成,本发明药物具有祛风散寒,除湿消肿,舒筋活血,定痛追毒的功能,用于治疗膝关节骨性关节炎治愈率高,不复发。
Description
技术领域
本发明涉及一种治疗膝关节骨性关节炎的药物,属中药领域。
背景技术
骨性关节炎又称增生性关节炎或退化性关节炎,早期症状为关节持续性酸痛或活动时突感刺痛,关节活动不灵活,晚期骨质和关节肥大,产生关节变形,X线检查显示关节边缘尖锐或有骨刺形成,关节间隙变窄,软骨下骨质硬化等症状。西药治疗效果不明显,只能治表不治本,且含有一定的毒副作用。
发明内容
因此,人们对疗效较好的中药外用药物存在极大的期望和需求,至今为止还没有发现关于本发明的有关报道,本发明人经过反复的研究试验,并通过临床试验的反复验证,终于成功的研制出治疗骨性关节炎的药物,从而完成了本发明。
本发明的目的就是提供一种治疗膝关节骨性关节炎的组合药物,以满足患者的需求。
本发明的另一个目的就是提供了该组合药物的制备方法。
本发明药物是选择威灵仙、川乌头、草乌头、黄芪、透骨草、伸筋草、鸡血藤、防风、骨碎补、桂枝、马钱子、红花、川牛膝、大黄、乳香、没药、续断、桑寄生、当归、羌活、独活、黄柏、杜仲、苍术、泽泻、薏苡仁、姜黄、苏木、川芎进行组合的,将这些药物组合,使得各药物功效产生协同作用,从而能够有效治疗骨性关节炎的复发。其中选用威灵仙是因为其性味辛咸,温,有毒,入膀胱经,有祛风湿,通经络,消痰涎,散癖积的功能,治痛风、顽痹、腰膝冷痛,脚气,疟疾,癥瘕积聚,破伤风,扁桃体炎,诸骨鲠咽。选用川乌头,异名川乌,其性味辛,热,有毒,入脾、命门二经,有祛寒湿,散风邪,温经,止痛的功能,治风寒湿痹,历节风痛,四肢拘挛,半身不遂,头风头痛,心腹冷痛,阴疽肿毒。选用草乌头,异名草乌,其性味辛,热,有毒,入肝、脾、肺经,有搜风胜湿,散寒止痛,开痰,消肿的功能,治风寒湿痹,中风瘫痪,破伤风,头风,脘腹冷痛,痰癖,气块,冷痢,喉痹,痈疽,疔疮,瘰疬。选用黄芪是因为其性味甘,微温,入肺、脾经,生用有益卫固表,利水消肿,托毒,生肌的功能,治自汗,盗汗,血痹,浮肿,痈疽不溃或溃久敛;炙用有补中益的功能,治内伤劳倦,脾虚泄泻,脱肛,气虚血脱,崩带及一切气衰血虚之症。选用透骨草是因为其性味辛温,有祛风,除湿,舒筋,活血,止痛的功能,治风湿痹痛,筋骨挛缩,疮癣肿毒。选用伸筋草是因为其性味苦辛,温,入肝、胃、肾三经,有祛风散寒,除湿消肿,舒筋活血的功能,治风寒湿痹,关节酸痛,皮肤麻木,四肢软弱,水肿,跌打损伤。选用鸡血藤是因为其性味苦甘,温,入心、脾二经,有活血、舒筋的功能,治腰膝酸痛,麻木瘫痪,***。选用防风是因为其性味辛甘,温,入膀胱、肺、脾经,有发表,祛风,胜湿,止痛的功能,治外感风寒,头痛,目眩,项强,风寒湿痹,骨节酸痛,四肢挛急,破伤风。选用骨碎补是因为其性味苦,温,入肝、肾经,有补肾,活血,止血的功能,治肾虚久泻及腰痛,风湿痹痛,齿痛,耳鸣,跌打闪挫、骨伤,阑尾炎,斑秃,鸡眼。选用桂枝是因为其性味辛甘,温,入膀胱、心、肺经,有发汗解肌,温经通脉的功能,治风寒表证,肩背肢节酸疼,胸痹痰饮,经闭癥瘕。选用马钱子是因为其性味苦,寒,有毒,有散血热,消肿,止痛的功能,治咽喉痹痛,痈疽肿毒,风痹疼痛,骨折,并治面神经麻痹,重症肌无力。选用红花是因为其性味辛,温,入心、肝经,有活血通经,去瘀止痛的功能,治经闭,癥瘕,难产,死胎,产后恶露不行,瘀血作痛,痈肿,跌扑损伤。选用川牛膝是因为其性味平,味苦微苦,无毒,入肝、肾二经,有祛风,利湿,通经,活血的功能,治风湿腰膝疼痛,脚痿筋挛,血淋,尿血,妇女经闭,癥瘕。选用大黄是因为其性味苦、寒,入胃、大肠、肝径,有泻热毒,破积滞,行瘀血的功能,治实热便秘,谵语发狂,食积痞满,痢疾初起,里急后重,瘀停经闭,癥瘕积聚,时行热疫,暴眼赤痛,吐血,衄血,阳黄,水肿,淋浊,溲赤,痈疡肿毒,疔疮,汤火伤。选用乳香是因为其性味辛苦,温,入心、肝、脾经,有调气活血,定痛,追毒的功能,治气血凝滞,心腹疼痛,痈疮肿毒,跌打损伤,痛经,产后瘀血刺痛。选用没药是因为其性味苦,平,入肝经,有散血去瘀,消肿定痛的功能,治跌损,金疮,筋骨,心腹诸痛,癥瘕,经闭,痈疽肿痛,痔漏,目障。选用续断是因为其性味苦辛,微温,入肝、肾经,有补肝肾,续筋骨,调血脉的功能,治腰背酸痛,足膝无力,胎漏,崩漏,带下,遗精,跌打损伤,金疮,痔漏,痈疽疮肿。选用桑寄生是因为其性味苦甘,平,入肝、肾经,有补肝肾,强筋骨,除风湿,通经络,益血,安胎的功能,治腰膝酸痛,筋骨痿弱,偏枯,脚气,风寒湿痹,胎漏血崩,产后乳汁不下。选用当归是因为其性味甘辛,温,入心、肝、脾经,有补血活血,调经止痛,润燥滑肠的功能,治***,经闭腹痛,癥瘕结聚,崩漏,血虚头痛,眩晕,痿痹,肠燥难便,赤痢后重,痈疽疮疡,金疮,跌扑损伤。选用羌活是因为其性味辛苦,温,入膀胱、肾经,有散表寒,祛风湿,利关节的功能,治感冒风寒,头痛无汗,风寒湿痹,项强筋急,骨节酸疼,风水浮肿,痈疽疮毒。选用独活是因为其性味辛苦,温,入肾、膀胱经,有祛风,胜湿,散寒,止痛的功能,治风寒湿痹,腰漆酸痛,手脚挛痛,慢性气管炎,头痛,齿痛。选用黄柏是因为其性味苦,寒,入肺、胃、肾经,有滋阴降火,润燥滑肠的功能,治烦热消渴,骨蒸劳热,肺热咳嗽,大便燥结,小便不利。选用杜仲是因为其性味甘微辛,温,入肝、肾经,有补肝肾,强筋骨,安胎的功能,治腰脊酸疼,足膝痿弱,小便余沥,阴下湿痒,胎漏欲堕,高血压。选用苍术是因为其性味辛苦,温,入脾、胃经,有健脾,燥湿,解郁,辟秽的功能,治湿盛困脾,倦怠嗜卧,脘痞腹胀,食欲不振,呕吐,泄泻,痢疾,疟疾,痰饮,水肿,时气感冒,风寒湿痹,足痿,夜盲。选用泽泻是因为其性味甘,寒,入膀胱经,有利水,渗湿,泄热的功能,治小便不利,水肿肛满,呕吐,泻痢,痰饮,脚气,淋病,尿血。选用薏苡仁是因为其性味甘淡,凉,入脾、肺、肾经,有健脾,补肺,清热,利湿的功能,治泄泻,湿痹,筋脉拘挛,屈伸不利,水肿,脚气,肺痿,肺痈,肠痈,淋浊,白带。选用姜黄是因为其性味辛苦,温,入脾、肝经,有破血,行气,通经,止痛的功能,治心腹痞满胀痛,臂痛,癥瘕,妇女血瘀经闭,产后瘀停腹痛,跌扑损伤,痈肿。选用苏木是因为其性味甘、咸、平,有行血,破瘀,消肿,止痛的功能,治妇人血气心腹痛,经闭,产后瘀血,胀痛喘急,痢疾,破伤风。选用川芎是因为其性味辛,温,入肝、胆经,有行气开郁,祛风燥湿,活血止痛的功能,治风冷头痛旋晕,胁痛腹疼,寒痹筋挛,经闭,难产,产后瘀阻块痛,痈疽疮疡。
本发明药物组分的用量也是发明人经过大量的摸索总结得出的,各组分的用量在下述重量范围内都具有较好的疗效。
威灵仙 10-20克 川乌头 8-12克 草乌头 8-12克
黄 芪 40-60克 透骨草 24-40克 伸筋草 130-160克
鸡血藤 8-15克 防 风 8-15克 骨碎补 8-15克
桂 枝 40-60克 马钱子 0.1-0.45克 红 花 8-15克
川牛膝 15-25克 大 黄 10-20克 乳 香 8-15克
没 药 8-15克 续 断 15-25克 桑寄生 8-15克
当 归 25-35克 羌 活 8-15克 独 活 8-15克
黄 柏 8-15克 杜 仲 15-25克 苍 术 8-15克
泽 泻 8-15克 薏苡仁 8-15克 姜 黄 8-15克
苏 木 8-15克 川 芎 8-15克
优选为
威灵仙 15克 川乌头 10克 草乌头 10克
黄 芪 50克 透骨草 30克 伸筋草 150克
鸡血藤 10克 防 风 10克 骨碎补 10克
桂 枝 50克 马钱子 0.1克 红 花 10克
川牛膝 20克 大 黄 15克 乳 香 10克
没 药 10克 续 断 20克 桑寄生 10克
当 归 30克 羌 活 10克 独 活 10克
黄 柏 10克 杜 仲 20克 苍 术 10克
泽 泻 10克 薏苡仁 10克 姜 黄 10克
苏 木 10克 川 芎 10克
本发明药物的制备方法如下
一、备料
1、威灵仙:拣净杂质,除去残茎,用水浸泡,捞出润透,切段,晒干;
2、川乌头:拣去杂质,洗净灰屑,晒干;
3、草乌头:取原药材,除去杂质,洗净,干燥,用时捣碎;
4、黄芪:拣净杂质,除去残留的根头和空心较大的根,用水浸泡,捞出,润透后及时切片,晒干;
5、透骨草:拣净杂质,切段;
6、伸筋草:筛去灰屑,拣净杂质,切成小段;
7、鸡血藤:用水润透,切片,或蒸软后趁热切片,晒干;
8、防风:除去残茎,用水浸泡,捞出,润透切片,晒干;
9、骨碎补:去净泥砂杂质,洗净,稍浸泡,润透,切片,晒干;
10、桂枝:用水稍浸泡,捞出,闷润至透,切片,晾干,筛去屑;
11、马钱子:取原药材,除去杂质;
12、红花:拣净杂质,除去茎叶、蒂头,晒干;
13、川牛膝:拣去杂质,晾干;
14、大黄:拣净杂质,大小分档,焖润至内外湿度均匀,切片或切成小块、晒干;
15、乳香:拣去砂子杂质;
16、没药:拣去杂质,打成碎块;
17、续断:洗净泥沙,除去残留根头,润透后切片晒干,筛去屑;
18、桑寄生:用水洗净,润透,切段,晒干;
19、当归:拣去杂质,洗净,闷润,稍晾至内外温度适宜时,切片,晒干;
20、羌活:拣去杂质,洗净,润透,切片,晾干;
21、独活:拣去杂质,分开大小个,洗净,润透后切片,干燥;
22、黄柏:拣去杂质,用水洗净,捞出,润透,切片或切丝,晒干;
23、杜仲:除去粗皮,洗净,润透,切成方块或丝条,晒干;
24、苍术:拣去杂质,用水泡至七、八成透,捞出,润透后切片,晒干;
25、泽泻:拣去杂质,大小分档,用水浸泡至八成透,捞出,晒凉,闷润至内外湿度均匀,切片,晒干;
26、薏苡仁:取原药材,除去残留皮壳、杂质;
27、姜黄:拣去杂质,用水浸泡,捞起,润透后切片,晒干;
28、苏木:取原药材,锯成短段,再劈成碎片或镑片;
29、川芎:拣去杂质,分开大、小个,用水浸泡,晒晾,闷润后切片,干燥。
二、制备
1、将炮制好的原料药装入布袋中;
2、把装好的药袋放入可调温的电热锅中,加水3000-3500克;
3、浸泡15分钟后,启动开关,盖上锅盖加热,使药液升温冒出热气产生雾化,待药液温度达到42℃时即为治疗温度。
膝骨关节炎是一种多种因素引起的常见病,属于中医骨痹范畴,中老年人多见,以关节软骨损伤、软骨反应性增生为主要病理变化,临床以缓慢发展性膝关节疼痛、僵便、肿胀和功能活动受限为主要表现。目前西医尚无理想的治疗方法,服用西药、贴膏药、拨罐等只能缓解当时疼痛,关节病变逐渐加重畸型,病因病机整体属正虚、肝肾、髓海不足,而局部则多属血瘀、寒凝所致。外邪郁阻经络,气血运行不畅,则致局部肿胀疼痛,活动不利,治疗当以祛风,散寒,除湿,化瘀,散结为原则。《内经》云:“在筋守筋,在骨守骨。”“痛生于筋骨,治之以薰引”,因本病病位在筋骨,故治法用中药薰蒸正合此理,运用中药气疗,通过药物薰蒸渗透到局部病变,使药物有效成分通过开泄的腠理以温热之力直达病所。此药袋内的药物能缓解膝关节粘连,补气补血,温经通脉,使药效直达膝关节,能较迅速有效地阻止关节软骨的损坏,抑制骨反应性增生,改善血液循环,消除炎症,逐渐吸收增生组织,解除关节软组织的刺激与粘连,达到消除疼痛,恢复关节功能的目的。
组方中伸筋草有祛风散寒,除湿消肿,舒筋活血的功能为君药;川乌头、草乌头有散风邪,祛寒湿,搜风胜湿,消肿止痛的功能,二者为臣药,三味药共同发挥祛风散寒,除湿消肿,舒筋活血,搜风止痛的作用,治疗骨性关节炎效力全面,且以祛风散寒,舒筋活血为主可治本;桑寄生有补肝肾,强筋骨,除风湿,通经络的功能为佐药;川牛膝有祛风、利湿、通经、活血的功能为使药,与下余诸药可治标。
本发明将上述药物与下余诸药组合,使得各药物功效产生协同作用,从而能够有效治疗膝关节骨性关节炎的复发。
本发明药物具有祛风散寒,除湿消肿,舒筋活血,补肾调气,定痛追毒的功能,用于治疗膝关节骨性关节炎疗效好,治愈率高,无副作用。
具体实施方式
以下结合临床试验例进一步阐述本发明药物的有益效果。
将炮制好的原料药放入布袋中,将装好的药袋放入可调温的电加热锅中加水3000-3500克,浸泡15分钟后,启动开关,盖上锅盖加热,使药液升温冒出热气产生气雾,待温度达到42℃时,掀开锅盖,让患者卧在简易薰蒸床上,使患者俯卧位,患膝部位放在加热锅上熏蒸,控制药液温度40-45℃,每日一次,每次每个***20分钟,每袋熏蒸6次,6次以后再换药袋,直至症状功能恢复正常。50例患者中,有10例患者治疗10袋症状消失,22例患者治疗15袋症状消失,17例患者治疗30袋以上症状消失,1例患者放弃治疗,治愈率为98%。治疗过程中,嘱患者移动***,按顺序先薰蒸前面,内侧面,外侧面,后面,而每一个***20分钟薰蒸2袋以后逐渐增加薰蒸时间分别为30分钟、40分钟至60分钟以上,使蒸锅中雾化的药物气体充分薰蒸患处。
Claims (3)
1.一种治疗膝关节骨性关节炎的外用药物,其特征在于:它是由下列重量范围内的原料药制成:
威灵仙 10-20克 川乌头 8-12克 草乌头 8-12克
黄 芪 40-60克 透骨草 24-40克 伸筋草 130-160克
鸡血藤 8-15克 防 风 8-15克 骨碎补 8-15克
桂 枝 40-60克 马钱子 0.1-0.45克 红 花 8-15克
川牛膝 15-25克 大 黄 10-20克 乳 香 8-15克
没 药 8-15克 续 断 15-25克 桑寄生 8-15克
当 归 25-35克 羌 活 8-15克 独 活 8-15克
黄 柏 8-15克 杜 仲 15-25克 苍 术 8-15克
泽 泻 8-15克 薏苡仁 8-15克 姜 黄 8-15克
苏 木 8-15克 川 芎 8-15克。
2.根据权利要求1所述的外用药物,其中各原料药的用量为:
威灵仙 15克 川乌头 10克 草乌头 10克
黄 芪 50克 透骨草 30克 伸筋草 150克
鸡血藤 10克 防 风 10克 骨碎补 10克
桂 枝 50克 马钱子 0.1克 红 花 10克
川牛膝 20克 大 黄 15克 乳 香 10克
没 药 10克 续 断 20克 桑寄生 10克
当 归 30克 羌 活 10克 独 活 10克
黄 柏 10克 杜 仲 20克 苍 术 10克
泽 泻 10克 薏苡仁 10克 姜 黄 10克
苏 木 10克 川 芎 10克。
3.根据权利要求1或2所述外用药物的制备方法,它包括下列步骤:
(一)备料
(1)威灵仙:拣净杂质,除去残茎,用水浸泡,捞出润透,切段,晒干;
(2)川乌头:拣去杂质,洗净灰屑,晒干;
(3)草乌头:取原药材,除去杂质,洗净,干燥,用时捣碎;
(4)黄芪:拣净杂质,除去残留的根头和空心较大的根,用水浸泡,捞出,润透后及时切片,晒干;
(5)透骨草:拣净杂质,切段;
(6)伸筋草:筛去灰屑,拣净杂质,切成小段;
(7)鸡血藤:用水润透,切片,或蒸软后趁热切片,晒干;
(8)防风:除去残茎,用水浸泡,捞出,润透切片,晒干;
(9)骨碎补:去净泥砂杂质,洗净,稍浸泡,润透,切片,晒干;
(10)桂枝:用水稍浸泡,捞出,闷润至透,切片,晾干,筛去屑;
(11)马钱子:取原药材,除去杂质;
(12)红花:拣净杂质,除去茎叶、蒂头,晒干;
(13)川牛膝:拣去杂质,晾干;
(14)大黄:拣净杂质,大小分档,焖润至内外湿度均匀,切片或切成小块、晒干;
(15)乳香:拣去砂子杂质;
(16)没药:拣去杂质,打成碎块;
(17)续断:洗净泥沙,除去残留根头,润透后切片晒干,筛去屑;
(18)桑寄生:用水洗净,润透,切段,晒干;
(19)当归:拣去杂质,洗净,闷润,稍晾至内外温度适宜时,切片,晒干;
(20)羌活:拣去杂质,洗净,润透,切片,晾干;
(21)独活:拣去杂质,分开大小个,洗净,润透后切片,干燥;
(22)黄柏:拣去杂质,用水洗净,捞出,润透,切片或切丝,晒干;
(23)杜仲:除去粗皮,洗净,润透,切成方块或丝条,晒干;
(24)苍术:拣去杂质,用水泡至七、八成透,捞出,润透后切片,晒干;
(25)泽泻:拣去杂质,大小分档,用水浸泡至八成透,捞出,晒凉,闷润至内外湿度均匀,切片,晒干;
(26)薏苡仁:取原药材,除去残留皮壳、杂质;
(27)姜黄:拣去杂质,用水浸泡,捞起,润透后切片,晒干;
(28)苏木:取原药材,锯成短段,再劈成碎片或镑片;
(29)川芎:拣去杂质,分开大、小个,用水浸泡,晒晾,闷润后切片,干燥;
(二)制备
(1)将炮制好的原料药装入布袋中;
(2)把装好的药袋放入可调温的电热锅中,加水3000-3500克;
(3)浸泡15分钟后,启动开关,盖上锅盖加热,使药液升温冒出热气产生气雾,待药液温度达到42℃时即为治疗温度。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610541986.2A CN106039220A (zh) | 2016-07-12 | 2016-07-12 | 一种治疗膝关节骨性关节炎的外用药物及其制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610541986.2A CN106039220A (zh) | 2016-07-12 | 2016-07-12 | 一种治疗膝关节骨性关节炎的外用药物及其制备方法 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN106039220A true CN106039220A (zh) | 2016-10-26 |
Family
ID=57185288
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201610541986.2A Pending CN106039220A (zh) | 2016-07-12 | 2016-07-12 | 一种治疗膝关节骨性关节炎的外用药物及其制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN106039220A (zh) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107007724A (zh) * | 2017-04-20 | 2017-08-04 | 安阳古方医药科技有限公司 | 一种中药保健液及其制备方法 |
CN109172751A (zh) * | 2018-11-14 | 2019-01-11 | 山东中医药大学 | 一种膝骨关节炎中药复原修复药酒及其制备方法 |
CN110742957A (zh) * | 2019-11-15 | 2020-02-04 | 张磊 | 一种熏蒸中药组合物 |
CN110934968A (zh) * | 2019-12-04 | 2020-03-31 | 菏泽市圣医医疗科技有限公司 | 一种治疗膝关节增生关节炎的中药组合物及其制备方法 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102813860A (zh) * | 2012-08-03 | 2012-12-12 | 丁洪亮 | 一种治疗风湿骨病膏药 |
CN105106832A (zh) * | 2015-08-22 | 2015-12-02 | 十堰德远科技开发有限公司 | 一种治疗风湿性与类风湿性关节炎痹症用顽痹酒及其制备方法 |
CN105396058A (zh) * | 2015-12-09 | 2016-03-16 | 李进龙 | 一种治疗颈椎病的药物及其制备方法 |
-
2016
- 2016-07-12 CN CN201610541986.2A patent/CN106039220A/zh active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102813860A (zh) * | 2012-08-03 | 2012-12-12 | 丁洪亮 | 一种治疗风湿骨病膏药 |
CN105106832A (zh) * | 2015-08-22 | 2015-12-02 | 十堰德远科技开发有限公司 | 一种治疗风湿性与类风湿性关节炎痹症用顽痹酒及其制备方法 |
CN105396058A (zh) * | 2015-12-09 | 2016-03-16 | 李进龙 | 一种治疗颈椎病的药物及其制备方法 |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107007724A (zh) * | 2017-04-20 | 2017-08-04 | 安阳古方医药科技有限公司 | 一种中药保健液及其制备方法 |
CN107007724B (zh) * | 2017-04-20 | 2020-04-14 | 安阳古方医药科技有限公司 | 一种中药保健液及其制备方法 |
CN109172751A (zh) * | 2018-11-14 | 2019-01-11 | 山东中医药大学 | 一种膝骨关节炎中药复原修复药酒及其制备方法 |
CN109172751B (zh) * | 2018-11-14 | 2021-07-16 | 山东中医药大学 | 一种膝骨关节炎中药复原修复药酒及其制备方法 |
CN110742957A (zh) * | 2019-11-15 | 2020-02-04 | 张磊 | 一种熏蒸中药组合物 |
CN110934968A (zh) * | 2019-12-04 | 2020-03-31 | 菏泽市圣医医疗科技有限公司 | 一种治疗膝关节增生关节炎的中药组合物及其制备方法 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN100584369C (zh) | 一种外用治疗痹症中药组合物 | |
CN101167999B (zh) | 热敷熥及其制备方法 | |
CN105688174A (zh) | 一种止痛中药组合物及制备膏贴药的方法 | |
CN105833193A (zh) | 一种治疗风湿骨病膏药 | |
CN106039220A (zh) | 一种治疗膝关节骨性关节炎的外用药物及其制备方法 | |
CN106266045A (zh) | 一种防治经络疼痛的艾条及其制备方法 | |
CN103656406B (zh) | 一种治疗肺结核的药物及其制备方法 | |
CN105920570A (zh) | 一种速效治疗风湿骨病的外敷中药及制备方法 | |
CN102631655B (zh) | 一种治疗冠心病的药物及其制备方法 | |
CN104056220A (zh) | 一种治疗破伤风的药物及其制备方法 | |
CN105031013A (zh) | 一种治疗腰椎骨质增生的药物及其制备方法 | |
CN104398925A (zh) | 一种治疗皮肤病的药物及其制备方法 | |
CN103735916B (zh) | 一种治疗肾病综合症的药物及其制备方法 | |
CN103566066B (zh) | 一种治疗脂溢性皮炎的药物及其制备方法 | |
CN106166200A (zh) | 一种治疗水火烫伤的中药组合物 | |
CN102416049B (zh) | 一种小方型风湿消肿消痛膏药 | |
CN105412581A (zh) | 一种治疗桡骨茎突狭窄性腱鞘炎的中药制剂及制备方法 | |
CN104147512A (zh) | 治疗湿寒型坐骨神经痛的中药组合物 | |
CN104107373A (zh) | 治疗脚气、脚臭、脚汗的中药 | |
CN102784329A (zh) | 一种治疗运动损伤和肿胀型骨关节病外用熏洗中药 | |
CN103623297B (zh) | 一种治疗急性乳腺炎的药物及其制备方法 | |
CN103638403B (zh) | 一种治疗糖尿病肢端坏疽的药物及其制备方法 | |
CN103768465B (zh) | 一种治疗胁痛的药物及其制备方法 | |
CN106668514A (zh) | 一种治疗少精症的药物及其制备方法 | |
CN106421536A (zh) | 一种治疗坐骨神经痛的药物及其制备方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
RJ01 | Rejection of invention patent application after publication |
Application publication date: 20161026 |
|
RJ01 | Rejection of invention patent application after publication |