CN106309818A - 一种治疗产褥感染的药物组合物 - Google Patents
一种治疗产褥感染的药物组合物 Download PDFInfo
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- CN106309818A CN106309818A CN201610812295.1A CN201610812295A CN106309818A CN 106309818 A CN106309818 A CN 106309818A CN 201610812295 A CN201610812295 A CN 201610812295A CN 106309818 A CN106309818 A CN 106309818A
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- pharmaceutical composition
- semen
- herba
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Abstract
一种治疗产褥感染的药物组合物及其制备方法,该药物组合物由以下重量份的药物制成:血竭、肉桂、莲子、益母草、射干、桑椹、葶苈子、椿皮、地黄、板蓝根、赭石、鱼腥草、墨旱莲。通过水煮、醇提等工艺制成,本发明在治疗产后发热、腹痛和异常恶露,局部出现红肿、压痛等症状方面有良好的效果,治疗产褥感染450例,各实施例有效率平均达96%,效果明显,并且未发现不良反应与毒副作用,说明本发明药物组合物在治疗产褥感染疗效显著,具有良好推广价值。
Description
技术领域
本发明涉及医药发明领域,具体涉及一种治疗产褥感染的的药物组合物及其制备方法。
背景技术
产褥感染是指分娩时及产褥期生殖道受病原体感染,引起局部和全身的炎性反应;发病病因有自身感染、外来感染、感染病源体;发热、腹痛和异常恶露是最主要的临床表现,局部也会出现红肿、压痛的症状;由于机体抵抗力不同、炎症反应的程度、范围和部位的不同,临床表现有所不同,根据感染发生的部位将产褥感染分为以下几种类型:1.急性外阴、***、***;2.剖宫产腹部切口、子宫切口感染;3.急性子***、子宫肌炎;4、急性盆腔***炎、***;5、急性***炎、弥漫性腹膜炎;6脓毒血症及败血症。因此对产褥感染应做到早预防、早发现、早治疗,对于确保产妇和宝宝的健康都有十分重要的意义。
为了解决上述问题,发明人研发了一种治疗产褥感染的新药。
发明内容
本发明的目的是提供一种治疗产褥感染的药物组合物。
本发明的另一目的提供一种治疗产褥感染的药物组合物制备方法。
本发明提供的治疗产褥感染的药物组合物由以下重量份的药物制成:血竭5-20份、肉桂10-40份、莲子20-60份、益母草20-60份、射干10-30份、桑椹20-50份、葶苈子10-40份、椿皮10-40份、地黄10-30份、板蓝根10-40份、赭石10-40份、鱼腥草20-60份、墨旱莲10-40份。
优选的,本发明所述的药物组合物由以下重量份的药物制成:血竭7-18份、肉桂13-37份、莲子25-55份、益母草25-55份、射干12-28份、桑椹25-45份、葶苈子13-37份、椿皮13-37份、地黄12-28份、板蓝根13-37份、赭石13-37份、鱼腥草25-55份、墨旱莲13-37份。
进一步优选的,本发明所述的药物组合物由以下重量份的药物制成:血竭9-16份、肉桂16-33份、莲子28-52份、益母草28-52份、射干15-25份、桑椹28-42份、葶苈子18-32份、椿皮18-32份、地黄15-25份、板蓝根18-32份、赭石18-32份、鱼腥草30-50份、墨旱莲18-32份。
更进一步优选的,本发明所述的药物组合物由以下重量份的药物制成:血竭11-15份、肉桂20-30份、莲子35-45份、益母草35-45份、射干17-22份、桑椹32-38份、葶苈子20-30份、椿皮20-30份、地黄18-23份、板蓝根22-28份、赭石22-28份、鱼腥草35-45份、墨旱莲21-29份。
更进一步优选的,本发明所述的药物组合物由以下重量份的药物制成:血竭13份、肉桂25份、莲子40份、益母草40份、射干20份、桑椹35份、葶苈子25份、椿皮25份、地黄20份、板蓝根25份、赭石25份、鱼腥草40份、墨旱莲25份。
本发明所述的药物组合物还含有药学上可接受的载体或稀释剂。
本发明所述药物组合物为固体制剂或液体制剂,所述固体制剂为片剂、胶囊剂、颗粒剂或丸剂;所述液体制剂为口服液。
本发明所述的药物组合物的制备方法包括以下步骤:将血竭、肉桂、莲子、益母草、射干、桑椹、葶苈子、椿皮、地黄、板蓝根、赭石、鱼腥草、墨旱莲粉碎过筛,与药学上可接受的载体或稀释剂混合均匀,制备成制剂。
本发明所述的药物组合物的制备方法包括以下步骤:
1)分别称取重量份的药物,备用;
2)将肉桂、莲子粉碎成细粉,备用;
3)将血竭、赭石加6-11倍量的水煎煮3-5次,每次1-3小时,合并煎液,过滤,滤液浓缩、干燥,粉碎成细粉,备用;
4)将益母草、射干、桑椹、葶苈子、椿皮、地黄、板蓝根、鱼腥草、墨旱莲加10-16倍量的水煎煮2-5次,每次1-3小时,合并煎液,过滤,滤液浓缩、干燥,粉碎成细粉,备用;滤渣加入3倍量75%的乙醇浸泡3-6小时,过滤,滤液浓缩干燥,粉碎成细粉,备用;
5)将上述细粉混合均匀,加入辅料,制成药学上可接受的剂型。
优选的,本发明所述的药物组合物的制备方法包括以下步骤:
1)分别称取重量份的药物,备用;
2)将肉桂、莲子粉碎成细粉,备用;
3)将血竭、赭石加8倍量的水煎煮4次,每次2小时,合并煎液,过滤,滤液浓缩、干燥,粉碎成细粉,备用;
4)将益母草、射干、桑椹、葶苈子、椿皮、地黄、板蓝根、鱼腥草、墨旱莲加13倍量的水煎煮3次,每次2小时,合并煎液,过滤,滤液浓缩、干燥,粉碎成细粉,备用;滤渣加入3倍量75%的乙醇浸泡5小时,过滤,滤液浓缩干燥,粉碎成细粉,备用;
5)将上述细粉混合均匀,加入辅料,制成药学上可接受的剂型。
所述重量份数可以是μg、mg、g、kg等医药领域公知的重量单位。
倍量的含义是指药材的重量比。
所述药学上可接受的载体或稀释剂是指药学领域常规的药物载体,选自填充剂、粘合剂、崩解剂、润滑剂、表面活性剂或矫味剂中的一种或几种。
其中所述填充剂选自淀粉、蔗糖、乳糖、甘露醇、山梨醇、木糖醇、微晶纤维素或葡萄糖等;
所述粘合剂选自纤维素衍生物、藻酸盐、明胶或聚乙烯吡咯烷酮等;
所述崩解剂选自微晶纤维素、羧甲基淀粉钠、聚乙烯吡咯烷酮、低取代羟丙基纤维素或交联羧甲基纤维素钠;
所述润滑剂选自硬脂酸、聚乙二醇、碳酸钙、碳酸氢钠、二氧化硅、滑石粉或硬脂酸镁;
所述表面活性剂选自十二烷基苯磺酸钠、硬脂酸、聚氧乙烯-聚氧丙烯共聚物、脂肪酸山梨坦或聚山梨酯(吐温)等;
所述矫味剂选自阿斯巴甜、蔗糖素或糖精钠。
本发明提供的药物组合物具有以下优点:
本发明在治疗产后发热、腹痛和异常恶露,局部出现红肿、压痛等症状方面有良好的效果,治疗产褥感染450例,各实施例有效率平均达96%,效果明显,并且未发现不良反应与毒副作用,说明本发明药物组合物在治疗产褥感染疗效显著,具有良好推广价值。
具体实施方式
以下实施例用于说明本发明,但不用来限制本发明的范围。
实施例1
组方:血竭5g、肉桂10g、莲子20g、益母草20g、射干10g、桑椹20g、葶苈子10g、椿皮10g、地黄10g、板蓝根10g、赭石10g、鱼腥草20g、墨旱莲10g。
制备方法:
1)分别称取重量份的药物,备用;
2)将肉桂、莲子粉碎成细粉,备用;
3)将血竭、赭石加6倍量的水煎煮3次,每次1小时,合并煎液,过滤,滤液浓缩、干燥,粉碎成细粉,备用;
4)将益母草、射干、桑椹、葶苈子、椿皮、地黄、板蓝根、鱼腥草、墨旱莲加10倍量的水煎煮2次,每次1小时,合并煎液,过滤,滤液浓缩、干燥,粉碎成细粉,备用;滤渣加入3倍量75%的乙醇浸泡3小时,过滤,滤液浓缩干燥,粉碎成细粉,备用;
5)将上述细粉混合均匀,加入占混合均匀细粉重量2/7的淀粉,装入胶囊,制成胶囊剂。
实施例2
组方:血竭20g、肉桂40g、莲子60g、益母草60g、射干30g、桑椹50g、葶苈子40g、椿皮40g、地黄30g、板蓝根40g、赭石40g、鱼腥草60g、墨旱莲40g。
制备方法:
1)分别称取重量份的药物,备用;
2)将肉桂、莲子粉碎成细粉,备用;
3)将血竭、赭石加11倍量的水煎煮5次,每次3小时,合并煎液,过滤,滤液浓缩、干燥,粉碎成细粉,备用;
4)将益母草、射干、桑椹、葶苈子、椿皮、地黄、板蓝根、鱼腥草、墨旱莲加16倍量的水煎煮5次,每次3小时,合并煎液,过滤,滤液浓缩、干燥,粉碎成细粉,备用;滤渣加入3倍量75%的乙醇浸泡6小时,过滤,滤液浓缩干燥,粉碎成细粉,备用;
5)将上述细粉混合均匀,加入占混合均匀细粉重量2/12的淀粉,装入胶囊,制成胶囊剂。
实施例3
组方:血竭7g、肉桂13g、莲子25g、益母草25g、射干12g、桑椹25g、葶苈子13g、椿皮13g、地黄12g、板蓝根13g、赭石13g、鱼腥草25g、墨旱莲13g。
制备方法:
1)分别称取重量份的药物,备用;
2)将肉桂、莲子粉碎成细粉,备用;
3)将血竭、赭石加7倍量的水煎煮4次,每次2小时,合并煎液,过滤,滤液浓缩、干燥,粉碎成细粉,备用;
4)将益母草、射干、桑椹、葶苈子、椿皮、地黄、板蓝根、鱼腥草、墨旱莲加12倍量的水煎煮3次,每次2小时,合并煎液,过滤,滤液浓缩、干燥,粉碎成细粉,备用;滤渣加入3倍量75%的乙醇浸泡4小时,过滤,滤液浓缩干燥,粉碎成细粉,备用;
5)加入占混合均匀细粉重量1/8的淀粉,干燥,压片,即得本申请的片剂。
实施例4
组方:血竭18g、肉桂37g、莲子55g、益母草55g、射干28g、桑椹45g、葶苈子37g、椿皮37g、地黄28g、板蓝根37g、赭石37g、鱼腥草55g、墨旱莲37g。
制备方法:
1)分别称取重量份的药物,备用;
2)将肉桂、莲子粉碎成细粉,备用;
3)将血竭、赭石加10倍量的水煎煮4次,每次2小时,合并煎液,过滤,滤液浓缩、干燥,粉碎成细粉,备用;
4)将益母草、射干、桑椹、葶苈子、椿皮、地黄、板蓝根、鱼腥草、墨旱莲加15倍量的水煎煮4次,每次2小时,合并煎液,过滤,滤液浓缩、干燥,粉碎成细粉,备用;滤渣加入3倍量75%的乙醇浸泡5小时,过滤,滤液浓缩干燥,粉碎成细粉,备用;
5)加入占混合均匀细粉重量1/6的淀粉,混匀,制粒,干燥,整粒,得到本申请的颗粒剂。
实施例5
组方:血竭9g、肉桂16g、莲子28g、益母草28g、射干15g、桑椹28g、葶苈子18g、椿皮18g、地黄15g、板蓝根18g、赭石18g、鱼腥草30g、墨旱莲18g。
制备方法:
1)分别称取重量份的药物,备用;
2)将肉桂、莲子粉碎成细粉,备用;
3)将血竭、赭石加8倍量的水煎煮4次,每次2小时,合并煎液,过滤,滤液浓缩、干燥,粉碎成细粉,备用;
4)将益母草、射干、桑椹、葶苈子、椿皮、地黄、板蓝根、鱼腥草、墨旱莲加13倍量的水煎煮3次,每次2小时,合并煎液,过滤,滤液浓缩、干燥,粉碎成细粉,备用;滤渣加入3倍量75%的乙醇浸泡5小时,过滤,滤液浓缩干燥,粉碎成细粉,备用;
5)加入占混合均匀细粉重量1/10的糊精,混匀,制丸,干燥,得到本申请的微丸。
实施例6
组方:血竭16g、肉桂33g、莲子52g、益母草52g、射干25g、桑椹42g、葶苈子32g、椿皮32g、地黄25g、板蓝根32g、赭石32g、鱼腥草50g、墨旱莲32g。
制备方法:
1)分别称取重量份的药物,备用;
2)将肉桂、莲子粉碎成细粉,备用;
3)将血竭、赭石加8倍量的水煎煮4次,每次2小时,合并煎液,过滤,滤液浓缩、干燥,粉碎成细粉,备用;
4)将益母草、射干、桑椹、葶苈子、椿皮、地黄、板蓝根、鱼腥草、墨旱莲加13倍量的水煎煮3次,每次2小时,合并煎液,过滤,滤液浓缩、干燥,粉碎成细粉,备用;滤渣加入3倍量75%的乙醇浸泡5小时,过滤,滤液浓缩干燥,粉碎成细粉,备用;
5)将上述细粉混合均匀,加入占混合均匀细粉重量2/10的淀粉,装入胶囊,制成胶囊剂。
实施例7
组方:血竭11g、肉桂20g、莲子35g、益母草35g、射干17g、桑椹32g、葶苈子20g、椿皮20g、地黄18g、板蓝根22g、赭石22g、鱼腥草35g、墨旱莲21g。
制备方法:
1)分别称取重量份的药物,备用;
2)将肉桂、莲子粉碎成细粉,备用;
3)将血竭、赭石加8倍量的水煎煮4次,每次2小时,合并煎液,过滤,滤液浓缩、干燥,粉碎成细粉,备用;
4)将益母草、射干、桑椹、葶苈子、椿皮、地黄、板蓝根、鱼腥草、墨旱莲加13倍量的水煎煮3次,每次2小时,合并煎液,过滤,滤液浓缩、干燥,粉碎成细粉,备用;滤渣加入3倍量75%的乙醇浸泡5小时,过滤,滤液浓缩干燥,粉碎成细粉,备用;
5)将上述细粉混合均匀,加入占混合均匀细粉重量2/9的淀粉,装入胶囊,制成胶囊剂。
实施例8
组方:血竭15g、肉桂30g、莲子45g、益母草45g、射干22g、桑椹38g、葶苈子30g、椿皮30g、地黄23g、板蓝根28g、赭石28g、鱼腥草45g、墨旱莲29g。
制备方法:
1)分别称取重量份的药物,备用;
2)将肉桂、莲子粉碎成细粉,备用;
3)将血竭、赭石加8倍量的水煎煮4次,每次2小时,合并煎液,过滤,滤液浓缩、干燥,粉碎成细粉,备用;
4)将益母草、射干、桑椹、葶苈子、椿皮、地黄、板蓝根、鱼腥草、墨旱莲加13倍量的水煎煮3次,每次2小时,合并煎液,过滤,滤液浓缩、干燥,粉碎成细粉,备用;滤渣加入3倍量75%的乙醇浸泡5小时,过滤,滤液浓缩干燥,粉碎成细粉,备用;
5)将上述细粉混合均匀,加入占混合均匀细粉重量2/8的淀粉,装入胶囊,制成胶囊剂。
实施例9
组方:血竭13g、肉桂25g、莲子40g、益母草40g、射干20g、桑椹35g、葶苈子25g、椿皮25g、地黄20g、板蓝根25g、赭石25g、鱼腥草40g、墨旱莲25g。
制备方法:
1)分别称取重量份的药物,备用;
2)将肉桂、莲子粉碎成细粉,备用;
3)将血竭、赭石加8倍量的水煎煮4次,每次2小时,合并煎液,过滤,滤液浓缩、干燥,粉碎成细粉,备用;
4)将益母草、射干、桑椹、葶苈子、椿皮、地黄、板蓝根、鱼腥草、墨旱莲加13倍量的水煎煮3次,每次2小时,合并煎液,过滤,滤液浓缩、干燥,粉碎成细粉,备用;滤渣加入3倍量75%的乙醇浸泡5小时,过滤,滤液浓缩干燥,粉碎成细粉,备用;
5)将上述细粉混合均匀,加入占混合均匀细粉重量2/7的淀粉,装入胶囊,制成胶囊剂。
为了进一步简述本发明的有益效果,发明人做了临床试验,具体如下:
1、病例来源
在志愿者中随机选取450名产后患者进行实验,年龄在25-39岁之间,平均年龄26岁,患者临床症状为:发热、腹痛和异常恶露,局部出现红肿、压痛。
2、治疗方法
将上述患者平均分为9组,各组之间无显著性差异,将这9组患者分别服用本发明实施例1-9的药物,每天3次,每次3g,连续服用2-7天。
3、疗效标准
疗效标准参照《中医病症判断疗效标准》中有关疗效标准规定。
显效:临床症状全部消失,试验室检查正常。
有效:临床症状减轻,实验室检查改善或正常。
无效:临床症状无明显好转或加重。
4、实验结果
绝大部分患者在按照本发明方法使用药物2天左右会有症状明显减轻的感觉,继续服用3-7天后,症状消失或痊愈,效果见表1:
表1疗效统计表
组别 | 显效 | 有效 | 无效 | 合计 | 有效率(%) |
实施例1 | 42 | 6 | 2 | 50 | 96% |
实施例2 | 43 | 6 | 1 | 50 | 98% |
实施例3 | 40 | 7 | 3 | 50 | 94% |
实施例4 | 42 | 7 | 1 | 50 | 98% |
实施例5 | 40 | 6 | 4 | 50 | 92% |
实施例6 | 45 | 4 | 1 | 50 | 98% |
实施例7 | 41 | 6 | 3 | 50 | 94% |
实施例8 | 42 | 6 | 2 | 50 | 96% |
实施例9 | 45 | 4 | 1 | 50 | 98% |
治疗产褥感染450例,各实施例有效率平均达96%,效果明显,并且未发现不良反应与毒副作用,说明本发明药物组合物在治疗产褥感染疗效显著,具有良好推广价值。
典型病例:
病例1:杜某,女,29岁,顺产一女婴,产后6天自感产后恶露异常多、发热,***红肿。服用本发明的实施例1药物组合物2天后无发热现象,继续服用2天,各症状消失,痊愈。
病例2:田某,女,33岁,剖腹产一男婴。4天后出现腹痛、发热,经查检子宫肿大,服用本发明的实施例2药物组合物3天后无腹痛、发热现象,继续服用5天后,子宫恢复正常,痊愈。
病例3:韩某,女,26岁,顺产一男婴,出院后,发热、***红肿,服用本发明的实施例3药物组合物3天后,症状消失,痊愈。
病例4:李某,女27岁,顺产一女婴,2天后出现***红肿,服用本发明实施例4药物组合物3天后,症状消失,痊愈。
病例5:杜某,女,28岁,顺产一女婴,产后***灼热、坠痛、肿胀。服用本发明的实施例5药物组合物2天后无发热现象,继续服用2天,各症状消失,痊愈。
病例6:方某,女,33岁,顺产一女婴,产后***红肿、子宫肿胀,伴有浑浊液体渗出。服用本发明的实施例6药物组合物2天后***红肿现象减轻,继续服用7天,各症状消失,痊愈。
病例7:王某,女,25岁,顺产一男婴,产后妇检有边界不清的实质性包块,压痛明显,伴有寒战和高热。服用本发明的实施例7药物组合物3天后各症状减轻,继续服用8天,各症状消失,痊愈。
病例8:方某,女,29岁,顺产一女婴,产后寒战、恶心、呕吐、腹胀、下腹剧痛。服用本发明的实施例8药物组合物2天后各症状减轻,继续服用10天,各症状消失,痊愈。
病例9:郭某,女,26岁,顺产一男婴,产后***灼热、肿胀。服用本发明的实施例9药物组合物2天后无发热现象,继续服用3天,各症状消失,痊愈。
虽然,上文中已经用一般性说明、具体实施方式及试验,对本发明作了详尽的描述,但在本发明基础上,可以对之作出一些修改或改进,这对本领域技术人员而言是显而易见的。因此,在不偏离本发明精神的基础上所做的这些修改或改进,均属于本发明要求保护的范围。
Claims (10)
1.一种治疗产褥感染的药物组合物,其特征在于,该药物组合物由以下重量份的药物制成:血竭5-20份、肉桂10-40份、莲子20-60份、益母草20-60份、射干10-30份、桑椹20-50份、葶苈子10-40份、椿皮10-40份、地黄10-30份、板蓝根10-40份、赭石10-40份、鱼腥草20-60份、墨旱莲10-40份。
2.根据权利要求1所述的的药物组合物,其特征在于,该药物组合物由以下重量份的药物制成:血竭7-18份、肉桂13-37份、莲子25-55份、益母草25-55份、射干12-28份、桑椹25-45份、葶苈子13-37份、椿皮13-37份、地黄12-28份、板蓝根13-37份、赭石13-37份、鱼腥草25-55份、墨旱莲13-37份。
3.根据权利要求2所述的的药物组合物,其特征在于,该药物组合物由以下重量份的药物制成:血竭9-16份、肉桂16-33份、莲子28-52份、益母草28-52份、射干15-25份、桑椹28-42份、葶苈子18-32份、椿皮18-32份、地黄15-25份、板蓝根18-32份、赭石18-32份、鱼腥草30-50份、墨旱莲18-32份。
4.根据权利要求3所述的的药物组合物,其特征在于,该药物组合物由以下重量份的药物制成:血竭11-15份、肉桂20-30份、莲子35-45份、益母草35-45份、射干17-22份、桑椹32-38份、葶苈子20-30份、椿皮20-30份、地黄18-23份、板蓝根22-28份、赭石22-28份、鱼腥草35-45份、墨旱莲21-29份。
5.根据权利要求4所述的的药物组合物,其特征在于,该药物组合物由以下重量份的药物制成:血竭13份、肉桂25份、莲子40份、益母草40份、射干20份、桑椹35份、葶苈子25份、椿皮25份、地黄20份、板蓝根25份、赭石25份、鱼腥草40份、墨旱莲25份。
6.根据权利要求1-5任一项所述的药物组合物,其特征在于,该药物组合物还含有药学上可接受的载体或稀释剂。
7.根据权利要求6所述的药物组合物,其特征在于,所述药物组合物为固体制剂或液体制剂,所述固体制剂为片剂、胶囊剂、颗粒剂或丸剂;所述液体制剂为口服液。
8.一种制备权利要求1-5任一项所述的药物组合物的制备方法,其特征在于,该方法包括以下步骤:将血竭、肉桂、莲子、益母草、射干、桑椹、葶苈子、椿皮、地黄、板蓝根、赭石、鱼腥草、墨旱莲粉碎过筛,与药学上可接受的载体或稀释剂混合均匀,制备成制剂。
9.一种制备权利要求1-5任一项所述的药物组合物的制备方法,其特征在于,该方法包括以下步骤:
1)分别称取重量份的药物,备用;
2)将肉桂、莲子粉碎成细粉,备用;
3)将血竭、赭石加6-11倍量的水煎煮3-5次,每次1-3小时,合并煎液,过滤,滤液浓缩、干燥,粉碎成细粉,备用;
4)将益母草、射干、桑椹、葶苈子、椿皮、地黄、板蓝根、鱼腥草、墨旱莲加10-16倍量的水煎煮2-5次,每次1-3小时,合并煎液,过滤,滤液浓缩、干燥,粉碎成细粉,备用;滤渣加入3倍量75%的乙醇浸泡3-6小时,过滤,滤液浓缩干燥,粉碎成细粉,备用;
5)将上述细粉混合均匀,加入辅料,制成药学上可接受的剂型。
10.根据权利要求9所述的药物组合物的制备方法,其特征在于,该方法包括以下步骤:
1)分别称取重量份的药物,备用;
2)将肉桂、莲子粉碎成细粉,备用;
3)将血竭、赭石加8倍量的水煎煮4次,每次2小时,合并煎液,过滤,滤液浓缩、干燥,粉碎成细粉,备用;
4)将益母草、射干、桑椹、葶苈子、椿皮、地黄、板蓝根、鱼腥草、墨旱莲加13倍量的水煎煮3次,每次2小时,合并煎液,过滤,滤液浓缩、干燥,粉碎成细粉,备用;滤渣加入3倍量75%的乙醇浸泡5小时,过滤,滤液浓缩干燥,粉碎成细粉,备用;
5)将上述细粉混合均匀,加入辅料,制成药学上可接受的剂型。
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