CN106309512A - Method for preparing ganoderma wall-broken decoction pieces - Google Patents
Method for preparing ganoderma wall-broken decoction pieces Download PDFInfo
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- CN106309512A CN106309512A CN201610820662.2A CN201610820662A CN106309512A CN 106309512 A CN106309512 A CN 106309512A CN 201610820662 A CN201610820662 A CN 201610820662A CN 106309512 A CN106309512 A CN 106309512A
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
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- A61K2236/10—Preparation or pretreatment of starting material
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Abstract
The invention provides a method for preparing ganoderma wall-broken decoction pieces. The method includes picking and cleaning medicinal materials and drying and crushing the medicinal materials; grinding the medicinal materials by the aid of grinders with 100-mesh sieves; intermittently sterilizing the medicinal materials; breaking walls; adding auxiliary materials into the medicinal materials and preparing soft materials; granulating and drying the soft materials to obtain the ganoderma wall-broken decoction pieces. The method has the advantages that granules of the decoction pieces prepared by the aid of the method are good in shape and moderate in tightness; the granules prepared by the aid of the method are easy to dry, high in dissolution speed and good in stability, the quality stability can be improved, the decoction pieces are easy to dispersed when users drink the decoction pieces, microbial limit requirements can be met by the decoction pieces which are intermittently sterilized, and problems of difficulty in dissolving ganoderma wall-broken decoction pieces on current markets and difficulty in reaching standards on microbial limit can be solved.
Description
Technical field
The present invention relates to the deep process technology field of edible and medical fungi, particularly belong to the preparation side of a kind of ganoderma lucidum wall-broken decoction pieces
Method.
Background technology
Ganoderma is a kind of large-scale medicinal fungi, belongs to Basidiomycetes Polyporaceae Ganoderma fungus, including Ganoderma lucidum (Leyss. Ex Fr.) Karst. and Ganoderma.
China's pharmacy monograph Shennong's Herbal the earliest and successive dynasties medical book are classified as top grade medicine category, and to its invigorating middle warmer benefit
The effects such as gas, YIN nourishing are strong, strengthening the body resistance, life lengthening are described.Modern scientific research shows, Ganoderma have antitumor,
Raising immunity of organism is active, remove free radical, improve cardiovascular and cerebrovascular vessel function, improve the ability of body synthetic DNA, to nervus centralis
The sedation of system and improve the pharmacological actions widely such as sleep state.Ganoderma close structure, has preferable maintenance energy, spirit
Sesame polysaccharide is present in cell wall, it is more difficult to ooze out.The effective ingredient the most effectively making Ganoderma is quickly leached, direct shadow
Ring the clinical efficacy to Ganoderma, it addition, the requirement that Ganoderma microbial limit is effectively ensured also is a big problem.Superfine communication technique
It it is the new technique developed rapidly in recent years.Effective ingredient in Chinese crude drug is distributed in intracellular mostly, and conventional decoction pieces decocts
Time part effective ingredient can only be made to discharge, utilization rate of active components 10-30%；And use wall breaking pulverization technology, in inciting somebody to action
Medicine decoction pieces is crushed to about 300 mesh, and cell-wall breaking ratio is up to 86.7%, improves the dissolution of effective ingredient in medical material, significantly
Strengthening its drug effect, utilization rate of active components, more than 90%, reaches to reduce medical material usage amount and protection herb resource, the most also may be used
The quality improving medicine increases drug effect.
CN200610122171.7 discloses the processing method of a kind of traditional Chinese herbs broken wall powder, and the step of its processing is: (1) medical material
Concoct: it includes selection, section, dried clean medical material；(2) pulverize: with above-mentioned clean medical material, with the omnipotent powder of 100 mesh sieves
Broken machine is pulverized, and wall breaking pulverization obtains the 60 above coarse powder of mesh；(3) wall breaking pulverization: by coarse powder flour obtained as above, through wall cell disruption powder powder
It is broken to more than 300 mesh, obtains superfine powder；(4) pelletize: take superfine powder obtained as above, put in flute profile mixing and blending machine, use water
Or ethanol makes soft material, pelletizing through the oscillating granulator of 30 mesh sieves, the wet granular prepared is put in heated-air circulation oven and is dried；
(5) granulate, screening: with upper strata 40 mesh, above-mentioned granulation granulate is sieved 1-3 time, makes 40 by the vibration pelletizing machine of lower floor 80 mesh sieve
Granule between mesh-80 mesh；(6) subpackage and packaging: take qualified sub-micron-powder, subpackage and outer package and obtain finished product.
CN201510230491.3 discloses the preparation method of a kind of Ganoderma pure powder ultramicro decoction piece, comprises the following steps: will be new
Process processed by fresh Ganoderma raw material cleaning, cutting, big gun；Pulverize, make coarse powder, sterilization treatment；-30 DEG C～-35 DEG C of lyophilizations
1.5-3 hour；It is warming up to 40 DEG C～50 DEG C, sublimation drying 15～24 hours；Dried coarse powder Ganoderma is added superfine grinding
Beating powder in machine, after beating powder, the particle diameter of the pure powder of described Ganoderma is 0.5-2 μm, obtains ultramicro decoction piece.Described sterilization treatment is that ray goes out
One or more of bacterium, microwave sterilizating, wet-hot steam sterilizing or ozone sterilization.Microbial limit is not carried out accordingly by this technique
Explanation, those skilled in the art cannot predict, additionally the method prepare tablet how leach effect, the most unpredictable.
According to current technique, prepared ganoderma lucidum wall-broken decoction pieces not only fastens, and granule is less, in actually used mistake
Journey is difficult to leach, is unfavorable for the Fast Stripping of active ingredient；Medical material only selection, section, to the medical material needing special processing
Inapplicable；For entering whether the coarse powder of clean area meets microbial limit and do not provide processing method；In pelletization,
There is certain deficiency in the stability of grain.
Summary of the invention
For the deficiencies in the prior art, the present invention provides the preparation method of a kind of ganoderma lucidum wall-broken decoction pieces, prepared by the method
Ganoderma lucidum wall-broken decoction pieces particle type is preferable, degree of tightness appropriateness, is easier to be dried, and granule leaches soon, and active ingredient dissolution is fast, granule
Good stability, quality stability increases, and the microbial limit of products obtained therefrom meets the requirements, and can guarantee that drug safety and effectively,
The time of ganoderma lucidum wall-broken decoction pieces prepared by employing the method is short, and process costs is low.
For solving above-mentioned technical problem, the present invention provides following technical scheme:
The preparation method of a kind of ganoderma lucidum wall-broken decoction pieces, described Ganoderma is through picking cleaning, dry, broken, the powder of 100 mesh sieves
The pulverizing of broken machine, batch (-type) sterilization, breaking cellular wall, add adjuvant soft material, pelletize, be dried prepare ganoderma lucidum wall-broken decoction pieces.
The preparation method of a kind of ganoderma lucidum wall-broken decoction pieces, has following steps:
(1) medical material processes: Ganoderma through picking cleanings, medicinal material drying, pulverizer broken, 100 mesh sieves prepared after pulverizing
The Ganoderma coarse powder of 80～120 mesh；
(2) batch (-type) sterilization: the Ganoderma coarse powder after step (1) being processed carries out sterilizing-and hypopus grow-sterilizes again
Process, until obtaining meeting the Ganoderma coarse powder directly taking decoction pieces microbial limit；
(3) breaking cellular wall: the Ganoderma coarse powder after sterilization is ground into glossy ganoderma ultra-fine powder body；
(4) soft material processed: be placed in blender by the glossy ganoderma ultra-fine powder body that breaking cellular wall prepares, is subsequently added adjuvant stirring, uses water
Or the ethanol of variable concentrations makes Ganoderma soft material；
(5) pelletize: soft material is made ganoderma particles；
(6) ganoderma particles is prepared after drying ganoderma lucidum wall-broken decoction pieces.
Described step (1) Chinese crude drug is dried and refers to that Ganoderma is dried to water content below 10%；Described step (1) crushes
Refer to the Ganoderma mechanical crusher of the screen cloth of 10 mesh is broken into the little granule about 10 mesh.
What in described step (2), batch (-type) sterilized concretely comprises the following steps: (A) sterilizes: the Ganoderma medical material after step (1) being processed
Coarse powder is placed in climatic chamber and keeps drying sterilizing a period of time under uniform temperature；(B) hypopus growth: by medicinal material coarse powder
In climatic chamber temperature be 20～30 DEG C, relative humidity 70～80% environment in maintain 8～24 hours, then by constant temperature
The temperature of constant humidity cabinet be adjusted to 33～40 DEG C, relative humidity be adjusted to 83～92% maintain 8～24 hours；(C) sterilization again: enter
Medicinal material coarse powder is placed in climatic chamber drying sterilizing a period of time at a certain temperature by one step ground；Conventional sense medical material is thick
Microorganism situation in powder, prepares and meets the medicinal material coarse powder directly taking decoction pieces microbial limit；Described uniform temperature be 50～
80℃；Described a period of time is 0.5～8 hour；The thickness that described medicinal material coarse powder is placed in climatic chamber be 5mm～
30mm。
Further, the concretely comprising the following steps of batch (-type) sterilization in described step (2): (A) sterilizes: in climatic chamber 60
～at 70 DEG C, keep drying sterilizing 0.5～4h；(B) hypopus growth: medicinal material coarse powder temperature in climatic chamber is 20～30
DEG C, relative humidity 70～80% environment in maintain 12～15 hours；Then the temperature of climatic chamber is adjusted to 33～40
DEG C, relative humidity 83～92% environment in maintain 12～15 hours；(C) sterilization again: at climatic chamber 60～70 DEG C
Keep drying sterilizing 0.5～4h.
What in described step (2), batch (-type) sterilized concretely comprises the following steps: (A) sterilizes: the Ganoderma coarse powder after step (1) being processed
Place and keep drying sterilizing a period of time under uniform temperature in an oven；(B) hypopus growth: by the spirit after sterilization processing
Sesame coarse powder takes out from baking oven, pack, and when temperature is 20～30 DEG C, after being filled with water vapour in bag, sealing maintenance 8～24 is little
Time；(C) sterilization again: the Ganoderma coarse powder after hypopus grows is placed drying sterilizing one the most at a certain temperature
The section time；Microorganism situation in conventional sense Ganoderma coarse powder, prepares and meets that directly to take the Ganoderma of decoction pieces microbial limit thick
Powder；Described uniform temperature is 50～80 DEG C；Described a period of time is 0.5～8 hour；Described Ganoderma coarse powder is placed on constant temperature and humidity
Thickness in case is 5mm～30mm.
Further, in described step (2) in the concrete steps of batch (-type) sterilization: described a period of time is 0.5～4 little
Time；Described (B) hypopus grows: maintaining growth time is 12～15 hours.
Further, after in described step (2), batch (-type) has sterilized, the microorganism in conventional sense medicinal material coarse powder is not
Meet when directly taking decoction pieces microbial limit, repeat the growth of (B) hypopus and (C) sterilization process 1～4 times；Prepare and meet directly
Connect the medicinal material coarse powder taking decoction pieces microbial limit.
Further, in described step (2), the bag in batch (-type) sterilization is plastic bag or Fibre Bag etc..
Further, described step (2) is filled with water vapour to bag in batch (-type) sterilization, refers to be charged to by sack completely, bag
Son is supported in shape.
In described step (4), adjuvant is starch slurry, polyvinylpyrrolidone (PVP) liquid, Mel, syrup or a combination thereof.
Further, in the preparation of described step (4) soft material, superfine powder: the mass ratio of adjuvant is 10:0～10 and auxiliary
The amount of material is more than 0；Wherein said starch slurry: polyvinylpyrrolidone (PVP) liquid: Mel: the mass ratio of syrup be 0～10:0～
Amount X of one of 10:0～10:0～10 and starch slurry, polyvinylpyrrolidone liquid, Mel, syrup or a combination thereof, X value is:
0<X≤10.The i.e. value of adjuvant is X.
It is further preferred that in the preparation of described step (4) soft material, the mass ratio of adjuvant is more than 0, less than the ratio of superfine powder
Example.
Described step (5) is pelletized method particularly includes: the Ganoderma soft material the made granulator of 14～24 mesh sieves is entered
Row is pelletized, and completes until preparing granule；Described granulator is oscillating granulator or the squash type granulator of 14～24 mesh sieves.
In described step (5), pelletization adds while adding soft material in granulator glossy ganoderma ultra-fine powder body.
In the concrete grammar pelletized in described step (5), the mass ratio of soft material and glossy ganoderma ultra-fine powder body is 3～6:0.5
～1.
In described step (6), particle drying is carried out in heated-air circulation oven, design temperature 50～80 DEG C, be dried to
Moisture is less than or equal to 7%.
In described step (6), granule completes after drying, with upper strata 10 mesh, the concussion pelletizing machine granulate screening of bottom 24 mesh sieve
1～3 time, make granule between 10～24 mesh.
Breaking cellular wall in described step (3) method particularly includes: at room temperature and relative humidity in the environment of 30～70%, passes through
The Ganoderma medicinal material coarse powder of batch (-type) sterilization obtains superfine powder through wall breaking pulverization, controls operating pressure 0.5～0.8MPa, classification
Machine rotating speed is 20～40r/s, more than wall breaking pulverization to 300 mesh；Described room temperature refers to 18～26 DEG C.
In described step (4), blender is trough type mixing machine or wet mixing pelletizer, and the ethanol of described variable concentrations is
The concentration of finger ethanol is 30%～99%.
Further, before the Ganoderma soft material made is pelletized by described step (5) with the granulator of 14～24 mesh sieves,
A small amount of glossy ganoderma ultra-fine powder body is spilt, to avoid mesh screen to block to granulator.
The screening that the present invention uses the screen cloth clearly pelletized to carry out mesh number makes granularity moderate；Limit is used in pelletization
Adding soft material limit and add the method granulation of glossy ganoderma ultra-fine powder body, the particle type of gained is preferable, and elasticity is moderate, and the granule prepared
Being easier to be dried, granule leaches comparatively fast.
The sterilization process repeatable operation of Ganoderma coarse powder can strengthen sterilization effect, and cycle-index is the first shadow of sterilization process
The factor of sound, circulates the level that substantially can reach to meet the microbial limit directly taking decoction pieces 2 times.Traditional is xeothermic and damp and hot
The high temperature that sterilizing is both needed to more than 80 degrees Celsius processes, and material component exists certain destruction, especially to containing heat
The medical material of quick property composition is inapplicable.The present invention uses the method for batch (-type) sterilizing, the temperature of sterilization process at 50～80 degrees Celsius,
In the environment of keeping being dried, several without destroying to the composition of Ganoderma, and grow-go out brood body through the brood body-hypopus that goes out
Process, in the environment being grown in high humidity of hypopus, after hypopus grows into brood body, kills, and killing action is obvious,
It is beneficial to the preparation of follow-up ganoderma lucidum wall-broken decoction pieces, meets the requirement of the microbial limit directly taking decoction pieces.
Beneficial effects of the present invention:
The present invention provides the preparation method of a kind of ganoderma lucidum wall-broken decoction pieces, by using Ganoderma to clean/concoct through picking, do
Dry, broken, the pulverizer pulverizing of 100 mesh sieves, batch (-type) sterilization, breaking cellular wall, add adjuvant soft material, pelletize, be dried and prepare Ganoderma and break
Wall decoction pieces, the particle type of the decoction pieces of preparation is preferable, and elasticity is moderate, and the granule prepared is easier to be dried, and granule leaches relatively
Hurry up, granule stability is good, is easily dispersed when user is taken, and batch (-type) sterilization makes decoction pieces meet wanting of microbial limit
Ask, solve ganoderma lucidum wall-broken decoction pieces in the market and leach difficulty, granule stability difference and the difficult problem up to standard of microbial limit.
By killing the brood body of antibacterial in medicinal material coarse powder at a certain temperature, then under conditions of room temperature high humidity, allow not
Dormancy body grows up to bacterial propagule, then through killing the brood body of the antibacterial in medicinal material coarse powder at a certain temperature, the most repeatedly 0～
4 times, thus the purpose that reaches to sterilize the most thoroughly；Method for disinfection, can not only ensure with the spirit being prepared by the method for the present invention
Sesame breaking cellular wall decoction pieces meets the microbial limit requirement directly taking decoction pieces, and is able to ensure that the drug safety of ganoderma lucidum wall-broken decoction pieces
And drug effect.The sterilising temp of the medicinal material coarse powder of preparation is 50～80 degrees Celsius, several without impact on the content of medical material, so that it is guaranteed that medicine
Effect and sterilizing；Do not have the situation of the oxidized degeneration of medical material；The time of method is short, consumes energy low.The present invention uses constant temperature and humidity
Case, is effectively guaranteed the growing environment of hypopus in medicinal material coarse powder, can effectively prevent owing to medicinal material coarse powder is in interval simultaneously
Move during formula sterilizing and occur that foreign body, dust enter the situation of medicinal material coarse powder, effectively prevent secondary pollution, it can be ensured that Ganoderma
The drug safety of breaking cellular wall decoction pieces and drug effect.
It addition, the present invention uses is filled with water vapour in bag, it is effectively guaranteed the growth ring of hypopus in medicinal material coarse powder
The humidity in border, pack simultaneously can effectively prevent owing to medicinal material coarse powder occurs that in hypopus growth course foreign body, dust enter
The situation of medicinal material coarse powder, effectively prevents secondary pollution, it can be ensured that the drug safety of breaking cellular wall decoction pieces and drug effect.By employing system
Adding appropriate adjuvant during soft material, the particle type of gained is preferable, and elasticity is moderate, and the granule prepared is easier to be dried,
Grain leaches very fast.The method that the present invention provides adds adjuvant in pelletization, and prepared granule elasticity is moderate, to the later stage
Be dried, granulate strong, breaking cellular wall decoction pieces is easily dispersed when user is taken, and solves ganoderma lucidum wall-broken decoction pieces in the market and leaches
Problem difficult, that granule stability is poor and microbial limit difficulty is up to standard, prepared granule stability is good, keeps the most for a long time, carries
Rise the kind of breaking cellular wall decoction pieces, add adjuvant and can cover the bad smell of original medical material, taste etc., breaking cellular wall decoction pieces can be effectively improved
Mouthfeel is happier when making to take.
The preparation method that the present invention provides is simple, easily operates, low cost, is suitable for commercial Application.
Detailed description of the invention
With specific embodiment, the present invention is further illustrated below, but the present invention is not limited by following embodiment.
Embodiment 1
Ganoderma lucidum wall-broken decoction pieces
1) medical material process: by Ganoderma medical material through pick cleaning/process of preparing Chinese medicine, medicinal material drying to medical material water content 10% with
Under, the medical material mechanical crusher of the screen cloth of 10 mesh is broken into the little granule about 10 mesh；Coarse pulverization Ganoderma reaches further
About 100 mesh；
2) batch (-type) sterilization: go out bacterial propagule: Ganoderma coarse powder is placed in an oven, places thickness and is about 10mm, arrange
Temperature is 65 DEG C (actual temperature is 60～70 DEG C), keeps drying sterilizing 8h；Hypopus grows: the Ganoderma coarse powder after process is from baking
Taking out in case, pack, when temperature is 25 DEG C, after being filled with water vapour in bag, sealing maintains 12 hours；Go out bacterial propagule: will
Ganoderma coarse powder is put in baking oven, and placement thickness is 30mm, and arranging temperature is 75 DEG C (actual temperature is 70～80 DEG C), keeps being dried
Sterilization 4h；Microorganism situation in conventional sense Ganoderma coarse powder, must meet the Ganoderma directly taking decoction pieces microbial limit requirement
Coarse powder；
3) breaking cellular wall: by particle diameter the Ganoderma coarse powder of 100～120 mesh at room temperature and relative humidity in the environment of 30%, warp
Wall breaking pulverization, controls operating pressure and more than 20r/s, wall breaking pulverization to 300 mesh, obtains ultra-fine at 0.6MPa, grader rotating speed
Powder body (90% powder size is less than 45 microns)；
4) soft material processed: be placed in trough type mixing machine by prepared superfine powder, adds starch slurry and appropriate 50～60%
Ethanol, makes soft material, and starch slurry is 6:10 with the mass ratio of superfine powder；
5) pelletize: by step 4) the superfine powder soft material that makes puts into oscillating granulator, and pelletize with the screen cloth of 16 mesh, make
During grain, limit adds step 4) the superfine powder soft material that makes time limit add step 3) the glossy ganoderma ultra-fine powder body prepared, soft material is with ultra-fine
The ratio of powder body is 3:1；
6) it is placed in 70 DEG C～80 DEG C of baking ovens is dried taking qualified breaking cellular wall decoction pieces granule, dried granule upper strata 10
Mesh, the concussion pelletizing machine granulate of bottom 24 mesh sieve sieves 2 times, and subpackage i.e. obtains ganoderma lucidum wall-broken decoction pieces.
Embodiment 2
Ganoderma lucidum wall-broken decoction pieces
1) medical material processes: by Ganoderma through picking the water content cleaned/concoct, be dried to medical material below 10%, by Ganoderma
It is broken into the little granule about 10 mesh with the mechanical crusher of the screen cloth of 10 mesh；Coarse pulverization Ganoderma reaches about 100 mesh further；
2) batch (-type) sterilization: go out bacterial propagule: Ganoderma coarse powder is put in baking oven, places thickness and is about 5mm, arrange temperature
It is 70 DEG C (actual temperature is 65～75 DEG C), keeps drying sterilizing 4h；Hypopus grows: the Ganoderma coarse powder after process is from baking oven
Taking out, pack, when temperature is 20 DEG C, after being filled with water vapour in bag, sealing maintains 15 hours；Go out bacterial propagule again: will
Ganoderma coarse powder is put in baking oven, and placement thickness is 20mm, and arranging temperature is 65 DEG C (actual temperature is 60～70 DEG C), keeps being dried
Sterilization 6h；Repeat hypopus grow-again to go out bacterial propagule step 1 time, the microorganism situation in conventional sense Ganoderma coarse powder；
The Ganoderma coarse powder directly taking decoction pieces microbial limit requirement must be met；
3) breaking cellular wall: by particle diameter the Ganoderma coarse powder of 100～120 mesh at room temperature and relative humidity in the environment of 50%, warp
Wall breaking pulverization, controls operating pressure and more than 40r/s, wall breaking pulverization to 300 mesh, obtains ultra-fine at 0.5MPa, grader rotating speed
Powder body (90% powder size is less than 45 microns)；
4) soft material processed: prepared superfine powder is placed in trough type mixing machine, add polyvinylpyrrolidone (PVP) liquid and
Appropriate 30～40% ethanol, make soft material, superfine powder is 10:4 with the mass ratio of polyvinylpyrrolidone (PVP) liquid；
5) pelletize: by step 4) the superfine powder soft material that makes put into oscillating granulator forward direction screen cloth spills the most ultra-fine
Powder body, pelletizes with the screen cloth of 20 mesh, and during granulation, limit adds step 4) the superfine powder soft material that makes time limit add step 3) prepare
Glossy ganoderma ultra-fine powder body, the ratio of soft material and superfine powder is 3:0.5；
6) it is placed in 60 DEG C～70 DEG C of baking ovens is dried taking qualified breaking cellular wall decoction pieces granule, dried granule upper strata 10
Mesh, the concussion pelletizing machine granulate of bottom 24 mesh sieve sieves 1 time, and subpackage i.e. obtains ganoderma lucidum wall-broken decoction pieces.
Embodiment 3
Ganoderma lucidum wall-broken decoction pieces
1) medical material processes: by Ganoderma through picking the water content cleaned/concoct, be dried to medical material below 10%, by Ganoderma
It is broken into the little granule about 10 mesh with the mechanical crusher of the screen cloth of 10 mesh；Coarse pulverization Ganoderma reaches about 100 mesh further；
2) batch (-type) sterilization: go out bacterial propagule: Ganoderma coarse powder is put in baking oven, places thickness and is about 30mm, arrange temperature
Degree is 75 DEG C (actual temperature is 70～80 DEG C), keeps drying sterilizing 4h；Hypopus grows: the Ganoderma coarse powder after process is from baking oven
Middle taking-up, pack, when temperature is 25 DEG C, after being filled with water vapour in bag, sealing maintains 24 hours；Go out bacterial propagule again:
By Ganoderma coarse powder in an oven, placement thickness is 10mm, and arranging temperature is 75 DEG C (actual temperature is 70～80 DEG C), keeps being dried
Sterilization 0.5h；Repeat hypopus grow-again to go out bacterial propagule step 4 time, the microorganism feelings in conventional sense Ganoderma coarse powder
Condition；The Ganoderma coarse powder directly taking decoction pieces microbial limit requirement must be met；
3) breaking cellular wall: by particle diameter the Ganoderma coarse powder of 100～120 mesh at room temperature and relative humidity in the environment of 70%, warp
Wall breaking pulverization, controls operating pressure and more than 30r/s, wall breaking pulverization to 300 mesh, obtains ultra-fine at 0.8MPa, grader rotating speed
Powder body (90% powder size is less than 45 microns)；
4) soft material processed: prepared superfine powder is placed in trough type mixing machine, addition Mel and appropriate 60～70% second
Alcohol, makes soft material, and superfine powder is 10:2 with the ratio of Mel；
5) pelletize: by step 4) the superfine powder soft material that makes put into oscillating granulator forward direction screen cloth spills the most ultra-fine
Powder body, pelletizes with the screen cloth of 20 mesh, and during granulation, limit adds step 4) the superfine powder soft material that makes time limit add step 3) prepare
Glossy ganoderma ultra-fine powder body, the ratio of soft material and superfine powder is 6:1；
6) it is placed in 50 DEG C～60 DEG C of baking ovens is dried taking qualified breaking cellular wall decoction pieces granule, dried granule upper strata 10
Mesh, the concussion pelletizing machine granulate of bottom 24 mesh sieve sieves 3 times, and subpackage i.e. obtains ganoderma lucidum wall-broken decoction pieces.
Embodiment 4
Ganoderma lucidum wall-broken decoction pieces
1) medical material processes: by Ganoderma through picking the water content cleaned/concoct, be dried to medical material below 10%, by Ganoderma
It is broken into the little granule about 10 mesh with the mechanical crusher of the screen cloth of 10 mesh；Coarse pulverization Ganoderma reaches about 100 mesh further；
2) batch (-type) sterilization: go out bacterial propagule: Ganoderma coarse powder is put in baking oven, often dish placement thickness is about 25mm, if
Putting temperature is 55 DEG C (actual temperature is 50～60 DEG C), keeps drying sterilizing 0.5h；Hypopus grows: the Ganoderma coarse powder after process
Taking out from baking oven, pack, when temperature is 30 DEG C, after being filled with water vapour in bag, sealing maintains 8 hours；Antibacterial of again going out is numerous
Growing body: be put in baking oven by Ganoderma coarse powder, often thickness placed by dish is 5mm, arranges temperature and is 55 DEG C (actual temperature is 50～60
DEG C), keep drying sterilizing 8h；Again repeat hypopus grow-again to go out bacterial propagule 2 times, in conventional sense Ganoderma coarse powder
Microorganism situation；The coarse powder directly taking decoction pieces microbial limit requirement must be met；
3) breaking cellular wall: by particle diameter the Ganoderma coarse powder of 100～120 mesh at room temperature and relative humidity in the environment of 40%, warp
Wall breaking pulverization, controls operating pressure and more than 30r/s, wall breaking pulverization to 300 mesh, obtains ultra-fine at 0.7MPa, grader rotating speed
Powder body (90% powder size is less than 45 microns)；
4) soft material processed: prepared superfine powder is placed in trough type mixing machine, addition polyvinylpyrrolidone (PVP) liquid,
Mel and appropriate 80～99% ethanol, makes soft material, superfine powder: polyvinylpyrrolidone (PVP) liquid: the ratio of Mel is
10:2:1；
5) pelletize: by step 4) the superfine powder soft material that makes put into oscillating granulator forward direction screen cloth spills the most ultra-fine
Powder body, pelletizes with the screen cloth of 20 mesh, and during granulation, limit adds step 4) the superfine powder soft material that makes time limit add step 3) prepare
Glossy ganoderma ultra-fine powder body, the ratio of soft material and superfine powder is 6:0.5；
6) it is placed in 50 DEG C～60 DEG C of baking ovens is dried taking qualified breaking cellular wall decoction pieces granule, dried granule upper strata 10
Mesh, the concussion pelletizing machine granulate of bottom 24 mesh sieve sieves 3 times, and subpackage i.e. obtains ganoderma lucidum wall-broken decoction pieces.
Embodiment 5
Ganoderma lucidum wall-broken decoction pieces
1) medical material processes: by Ganoderma medical material through picking the water content cleaned/concoct, be dried to medical material below 10%, will
The medical material mechanical crusher of the screen cloth of 10 mesh is broken into the little granule about 10 mesh；Coarse pulverization medical material reaches 100 mesh further
Left and right；
2) batch (-type) sterilization: Ganoderma coarse powder is put in climatic chamber, places thickness and is about 30mm, and arranging temperature is 75 DEG C
(actual temperature is 70～80 DEG C), keeps drying sterilizing 4h；Medicinal material coarse powder after process is 25 DEG C, relative humidity 75% in temperature
Maintain 24 hours；Then the temperature of climatic chamber is adjusted to 40 DEG C, relative humidity 80% maintain 12 hours；By medicinal material coarse powder
In climatic chamber, placement thickness is 10mm, and arranging temperature is 80 DEG C (actual temperature is 75～85 DEG C), keeps drying sterilizing
0.5h；Repeat step 4 time, the microorganism situation in conventional sense medicinal material coarse powder；Must meet and directly take decoction pieces microbial limit
The Ganoderma coarse powder required；
3) breaking cellular wall: by particle diameter the medicinal material coarse powder of 100～120 mesh at room temperature and relative humidity in the environment of 50%, warp
Wall breaking pulverization, controls operating pressure and more than 40r/s, wall breaking pulverization to 300 mesh, obtains ultra-fine at 0.5MPa, grader rotating speed
Powder body (90% powder size is less than 45 microns)；
4) soft material processed: be placed in trough type mixing machine by prepared superfine powder, adds appropriate 30～40% ethanol and auxiliary
Material, adjuvant is starch slurry, polyvinylpyrrolidone (PVP) liquid and Mel, superfine powder: starch slurry: polyvinylpyrrolidone
(PVP) liquid: the mass ratio 10:5:1:4 of Mel, makes soft material；
5) pelletize: by step 4) the superfine powder soft material that makes put into oscillating granulator forward direction screen cloth spills the most ultra-fine
Powder body, pelletizes with the screen cloth of 20 mesh, and during granulation, limit adds step 4) the superfine powder soft material that makes time limit add step 3) prepare
Glossy ganoderma ultra-fine powder body, the ratio of soft material and superfine powder is 5:0.5；
6) it is placed in 60 DEG C～70 DEG C of baking ovens is dried taking qualified breaking cellular wall decoction pieces granule, dried granule upper strata 10
Mesh, the concussion pelletizing machine granulate of bottom 24 mesh sieve sieves 1 time, and subpackage i.e. obtains ganoderma lucidum wall-broken decoction pieces.
Embodiment 6
Ganoderma lucidum wall-broken decoction pieces
1) medical material processes: by Ganoderma medical material through picking the water content cleaned/concoct, be dried to medical material below 10%, will
The medical material mechanical crusher of the screen cloth of 10 mesh is broken into the little granule about 10 mesh；Coarse pulverization medical material reaches 100 mesh further
Left and right；
2) batch (-type) sterilization: Ganoderma coarse powder is put in climatic chamber, places thickness and is about 5mm, and arranging temperature is 70 DEG C
(actual temperature is 65～75 DEG C), keeps drying sterilizing 4h；Medicinal material coarse powder after process is 20 DEG C, relative humidity 70% in temperature
Maintain 15 hours；Then the temperature of climatic chamber is adjusted to 33 DEG C, relative humidity 83% maintain 8 hours；Change arranges temperature
Degree is 65 DEG C (actual temperature is 60～70 DEG C), keeps drying sterilizing 6h；Repeat hypopus grow-again go out bacterial propagule walk
Rapid 1 time, the microorganism situation in conventional sense medicinal material coarse powder；Must meet that directly to take the Ganoderma of decoction pieces microbial limit requirement thick
Powder；
3) breaking cellular wall: by particle diameter the medicinal material coarse powder of 100～120 mesh at room temperature and relative humidity in the environment of 70%, warp
Wall breaking pulverization, controls operating pressure and more than 30r/s, wall breaking pulverization to 300 mesh, obtains ultra-fine at 0.8MPa, grader rotating speed
Powder body (90% powder size is less than 45 microns)；
4) soft material processed: be placed in trough type mixing machine by prepared superfine powder, adds appropriate 60～70% ethanol and auxiliary
Material, adjuvant is starch slurry and Mel, superfine powder: starch slurry: the mass ratio 10:0.5:0.5 of Mel, makes soft material；
5) pelletize: by step 4) the superfine powder soft material that makes put into oscillating granulator forward direction screen cloth spills the most ultra-fine
Powder body, pelletizes with the screen cloth of 20 mesh, and during granulation, limit adds step 4) the superfine powder soft material that makes time limit add step 3) prepare
Glossy ganoderma ultra-fine powder body, the ratio of soft material and superfine powder is 4:0.8；
6) it is placed in 50 DEG C～60 DEG C of baking ovens is dried taking qualified breaking cellular wall decoction pieces granule, dried granule upper strata 10
Mesh, the concussion pelletizing machine granulate of bottom 24 mesh sieve sieves 3 times, and subpackage i.e. obtains ganoderma lucidum wall-broken decoction pieces.
Embodiment 7
Ganoderma lucidum wall-broken decoction pieces
1) medical material processes: by Ganoderma medical material through picking the water content cleaned/concoct, be dried to medical material below 10%, will
The medical material mechanical crusher of the screen cloth of 10 mesh is broken into the little granule about 10 mesh；Coarse pulverization medical material reaches 100 mesh further
Left and right；
2) batch (-type) sterilization: Ganoderma coarse powder is put in climatic chamber, places thickness and is about 15mm, and arranging temperature is 70 DEG C
(actual temperature is 65～75 DEG C), keeps drying sterilizing 3h；Medicinal material coarse powder after process is 20 DEG C, relative humidity 70% in temperature
Maintain 14 hours；Then the temperature of climatic chamber is adjusted to 33 DEG C, relative humidity 83% maintain 10 hours；Change arranges temperature
Degree is 65 DEG C (actual temperature is 60～70 DEG C), keeps drying sterilizing 5h；Repeat hypopus grow-again go out bacterial propagule walk
Rapid 1 time, the microorganism situation in conventional sense medicinal material coarse powder；Must meet that directly to take the Ganoderma of decoction pieces microbial limit requirement thick
Powder；
3) breaking cellular wall: by particle diameter the medicinal material coarse powder of 100～120 mesh at room temperature and relative humidity in the environment of 70%, warp
Wall breaking pulverization, controls operating pressure and more than 30r/s, wall breaking pulverization to 300 mesh, obtains ultra-fine at 0.8MPa, grader rotating speed
Powder body (90% powder size is less than 45 microns)；
4) soft material processed: be placed in trough type mixing machine by prepared superfine powder, adds appropriate 60～70% ethanol and auxiliary
Material, adjuvant is starch slurry and Mel, superfine powder: starch slurry: the mass ratio 10:1.5:6 of Mel, makes soft material；
5) pelletize: by step 4) the superfine powder soft material that makes puts into oscillating granulator, with the screen cloth granulation of 20 mesh；
6) it is placed in 50 DEG C～60 DEG C of baking ovens is dried taking qualified breaking cellular wall decoction pieces granule, dried granule upper strata 10
Mesh, the concussion pelletizing machine granulate of bottom 24 mesh sieve sieves 3 times, and subpackage i.e. obtains ganoderma lucidum wall-broken decoction pieces.
Leach time detecting test
Test method: take about 2g prepare dry granule be placed in the transparent cup of 300 milliliters, add 90 degrees Celsius Celsius to 95
100 milliliters of the water (being no longer heat up during shaking) of degree, shakes 1 minute, 2 minutes, 3 points with the clockwise direction of 1 circle per second
Clock, 5 minutes, see granule in cup after 10 minutes leach situation, separately take the American-European gram LS-609 laser grain of liquid 0.5 milliliter in cup
Degree instrument detection shading rate, result of the test see table 1:
Knowable to table 1 data, the superfine powder method of granulating that the present invention provides is more preferable than the effect of conventional method of granulating, molten
Go out speed ratio conventional method faster.
Microbial limit detection test
By " Chinese Pharmacopoeia " 2015 editions the 4th the 140-151 page
1105 non-sterile product microbial limit detections: microorganism count method
1106 non-sterile product microbial limit detections: Control bacteria examination method
1107 non-sterile medicine limitation standard in microbes
According to the method for pharmacopeia, the sample of embodiment 1～7 is carried out microbial limit detection to test, concrete outcome such as table 2:
The detection test of table 2 microbial limit
Knowable to table 2 data, batch (-type) sterilizing methods is more preferable than conventional dry heat sterilization effect, more can guarantee that hygiology matter
Amount.
Active constituent content measuring is tested
By " Chinese Pharmacopoeia " 2015 editions first
Page 188 is about Ganoderma detection method of content
Ganoderma coarse powder after sterilizing the batch (-type) of embodiment 1～7 according to the regulation of pharmacopeia carries out assay, specifically ties
Fruit is such as table 3:
Ganoderma coarse powder active constituent content measuring test after the sterilization of table 3 batch (-type)
As known from Table 3, the batch (-type) sterilizing methods that the present invention uses is several without impact, energy on the medical material content of embodiment 1～7
The effective active constituent content keeping Ganoderma coarse powder.
Study on the stability data
Test method: according to the 4th page 354 9001 " material medicine and preparation stabilities of " Chinese Pharmacopoeia " version in 2015
Test direction principle two accelerated test " the middle method specified, under conditions of temperature 40 DEG C ± 2 DEG C, relative humidity 75% ± 5%
Placing 6 months, testing, 1st month period, 2 months, 3 months, 6 the end of month are separately sampled once, detection level.Result of the test
See table 4:
By table 4 data, the content of the granule adding adjuvant granulation gained declines substantially than the conventional granule pelletized
Content decrease speed is little, say, that add the granule that the granule stability of adjuvant granulation is pelletized apparently higher than routine.
The foregoing is only the preferred embodiments of the present invention, be not limited to the present invention, for the skill of this area
For art personnel, the present invention can have various modifications and variations.All within the spirit and principles in the present invention, that is made any repaiies
Change, equivalent, improvement etc., should be included within the scope of the present invention.
Claims (10)
1. the preparation method of a ganoderma lucidum wall-broken decoction pieces, it is characterised in that there are following steps:
(1) medical material processes: medical material Ganoderma through picking cleanings, medicinal material drying, pulverizer broken, 100 mesh sieves prepared after pulverizing
The medicinal material coarse powder of 80～120 mesh；
(2) batch (-type) sterilization: the medicinal material coarse powder after step (1) being processed carries out sterilizing-mistake that grow-again sterilizes of hypopus
Journey, until obtaining meeting the medicinal material coarse powder directly taking decoction pieces microbial limit；
(3) breaking cellular wall: the medicinal material coarse powder after sterilization is ground into superfine powder；
(4) soft material processed: be placed in blender by the glossy ganoderma ultra-fine powder body that breaking cellular wall prepares, is not subsequently added adjuvant stirring, with water or not
Ganoderma soft material is made with the ethanol of concentration；Described adjuvant is starch slurry, polyvinylpyrrolidone liquid, Mel, syrup or a combination thereof；
(5) pelletize: soft material is made ganoderma particles；
(6) ganoderma lucidum wall-broken decoction pieces will be prepared after particle drying.
The preparation method of a kind of ganoderma lucidum wall-broken decoction pieces the most according to claim 1, it is characterised in that in described step (2)
Concretely comprising the following steps of batch (-type) sterilization: (A) sterilizes: the Ganoderma medicinal material coarse powder after step (1) being processed is placed on climatic chamber
Keep drying sterilizing a period of time under middle uniform temperature；(B) hypopus growth: be by medicinal material coarse powder temperature in climatic chamber
The environment of 20～30 DEG C, relative humidity 70～80% maintains 8～24 hours, then the temperature of climatic chamber is adjusted to 33
～40 DEG C, relative humidity be adjusted to 83～92% maintain 8～24 hours；(C) sterilization again: further medicinal material coarse powder is placed
Drying sterilizing a period of time at a certain temperature in climatic chamber；Microorganism situation in conventional sense medicinal material coarse powder, system
The medicinal material coarse powder directly taking decoction pieces microbial limit must be met；Described uniform temperature is 50～80 DEG C；Described a period of time is
0.5～8 hour；The thickness that described medicinal material coarse powder is placed in climatic chamber is 5mm～30mm.
The preparation method of a kind of ganoderma lucidum wall-broken decoction pieces the most according to claim 1, it is characterised in that in described step (2)
Concretely comprising the following steps of batch (-type) sterilization: (A) sterilizes: the Ganoderma coarse powder after step (1) being processed places uniform temperature in an oven
Lower holding drying sterilizing a period of time；(B) hypopus growth: the Ganoderma coarse powder after sterilization processing is taken out from baking oven,
Pack, when temperature is 20～30 DEG C, after being filled with water vapour in bag, sealing maintains 8～24 hours；(C) sterilization again: will be through
Cross the Ganoderma coarse powder after hypopus growth and place drying sterilizing a period of time the most at a certain temperature；Conventional sense Ganoderma
Microorganism situation in coarse powder, prepares and meets the Ganoderma coarse powder directly taking decoction pieces microbial limit；Described uniform temperature is 50
～80 DEG C；Described a period of time is 0.5～8 hour；The thickness that described Ganoderma coarse powder is placed in climatic chamber be 5mm～
30mm。
The preparation method of a kind of ganoderma lucidum wall-broken decoction pieces the most according to claims 2 to 3, it is characterised in that described step (2)
After middle batch (-type) has sterilized, the microorganism in conventional sense medicinal material coarse powder does not meets when directly taking decoction pieces microbial limit,
Repeat the growth of (B) hypopus and (C) sterilization process 1～4 times；Prepare and meet that directly to take the medical material of decoction pieces microbial limit thick
Powder.
The preparation method of a kind of ganoderma lucidum wall-broken decoction pieces the most according to claims 1 to 3, it is characterised in that described step (5)
Middle granulation method particularly includes: the Ganoderma soft material the made granulator of 14～24 mesh sieves is pelletized, in granulator
Adding superfine powder while adding soft material, completing until preparing granule；Described granulator is the oscillating granulator of 14～24 mesh sieves
Or squash type granulator.
The preparation method of a kind of ganoderma lucidum wall-broken decoction pieces the most according to claim 5, it is characterised in that in described step (5)
In the concrete grammar pelletized, the ratio of soft material and superfine powder is 3～6:0.5～1.
The preparation method of a kind of ganoderma lucidum wall-broken decoction pieces the most according to claims 1 to 3, it is characterised in that described step (4)
In soft material preparation, superfine powder: the mass ratio of adjuvant is 10:0～10, and the amount of adjuvant is more than 0；Wherein said starch slurry:
Polyvinylpyrrolidone liquid: Mel: the mass ratio of syrup is 0～10:0～10:0～10:0～10 and starch slurry, polyethylene pyrrole
The amount of one of pyrrolidone liquid, Mel, syrup or a combination thereof is less than or equal to 10 more than 0.
The preparation method of a kind of ganoderma lucidum wall-broken decoction pieces the most according to claims 1 to 3, it is characterised in that described step (6)
Middle particle drying is carried out in heated-air circulation oven, design temperature 50～80 DEG C, is dried to moisture less than or equal to 7%；Institute
Stating granule in step (6) and complete after drying, with upper strata 10 mesh, the concussion pelletizing machine granulate of bottom 24 mesh sieve sieves 1～3 time, system
Become granule between 10～24 mesh.
The preparation method of a kind of ganoderma lucidum wall-broken decoction pieces the most according to claims 1 to 3, it is characterised in that described step (3)
Middle breaking cellular wall method particularly includes: at room temperature and relative humidity in the environment of 30～70%, through the Ganoderma medicine of batch (-type) sterilization
Material coarse powder obtains superfine powder through wall breaking pulverization, controls operating pressure 0.5～0.8MPa, grader rotating speed 20～40r/s,
Wall breaking pulverization is to more than 300 mesh；Described room temperature refers to 18～26 DEG C.
The preparation method of a kind of ganoderma lucidum wall-broken decoction pieces the most according to claims 1 to 3, it is characterised in that described step
(4) in, blender is trough type mixing machine or wet mixing pelletizer, and the ethanol of described variable concentrations refers to that the concentration of ethanol is
30%～99%.
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| CN107441123A (en) * | 2017-08-09 | 2017-12-08 | 芜湖振龙齐欣药业有限公司 | A kind of preparation method of the broken wall prepared slices of Chinese crude drugs |
| CN107823229A (en) * | 2017-11-13 | 2018-03-23 | 贵州景诚制药有限公司 | Ganoderma lucidum wall-broken medicine materical crude slice and preparation method thereof |
| CN108967794A (en) * | 2018-06-29 | 2018-12-11 | 中山市中智药业集团有限公司 | A kind of straight drinking particle of broken wall |
| CN111743874A (en) * | 2020-07-22 | 2020-10-09 | 芜湖御草医药有限公司 | Method for preparing ganoderma lucidum spore powder capsule |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107441123A (en) * | 2017-08-09 | 2017-12-08 | 芜湖振龙齐欣药业有限公司 | A kind of preparation method of the broken wall prepared slices of Chinese crude drugs |
| CN107823229A (en) * | 2017-11-13 | 2018-03-23 | 贵州景诚制药有限公司 | Ganoderma lucidum wall-broken medicine materical crude slice and preparation method thereof |
| CN107823229B (en) * | 2017-11-13 | 2021-08-06 | 贵州景诚制药有限公司 | Ganoderma lucidum wall-broken decoction pieces and preparation method thereof |
| CN108967794A (en) * | 2018-06-29 | 2018-12-11 | 中山市中智药业集团有限公司 | A kind of straight drinking particle of broken wall |
| CN111743874A (en) * | 2020-07-22 | 2020-10-09 | 芜湖御草医药有限公司 | Method for preparing ganoderma lucidum spore powder capsule |
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