CN107441123A - A kind of preparation method of the broken wall prepared slices of Chinese crude drugs - Google Patents
A kind of preparation method of the broken wall prepared slices of Chinese crude drugs Download PDFInfo
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- CN107441123A CN107441123A CN201710674915.4A CN201710674915A CN107441123A CN 107441123 A CN107441123 A CN 107441123A CN 201710674915 A CN201710674915 A CN 201710674915A CN 107441123 A CN107441123 A CN 107441123A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
- A61L2/0023—Heat
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/17—Preparation or pretreatment of starting material involving drying, e.g. sun-drying or wilting
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
- A61L2202/20—Targets to be treated
- A61L2202/21—Pharmaceuticals, e.g. medicaments, artificial body parts
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Abstract
The present invention provides a kind of preparation method of the broken wall prepared slices of Chinese crude drugs, and the described broken wall prepared slices of Chinese crude drugs are prepared by steps such as raw material selection, drying, crushing, sieving, sterilization, microorganism growth, re-pasteurization, supersonic wave wall breaking, ultra-fine grinding, granulation, compacting, packaging, storages.The present invention uses discontinuous sterilization in broken wall prepared slices of Chinese crude drugs process, the technique that secondary broken wall crushes is handled prepared slices of Chinese crude drugs raw material, improve the sterilization quality of prepared slices of Chinese crude drugs raw material, secondary broken wall crushes the eduction rate for the active component that can be improved in prepared slices of Chinese crude drugs raw material, improve the utilization rate of prepared slices of Chinese crude drugs raw material, pelletized after raw material after super fine crushing is mixed with auxiliary material, make prepared slices of Chinese crude drugs stability good, leach fast, nutriment speed of separating out is high, existing broken wall medicine materical crude slice indissoluble is overcome to dissipate, absorptivity is low, the problem of stability difference, improve the product quality of the broken wall prepared slices of Chinese crude drugs.
Description
Technical field
The present invention relates to Technique for producing medicinal herbs in small pieces field, specifically a kind of preparation method of the broken wall prepared slices of Chinese crude drugs.
Background technology
Superfine communication technique is the new technology developed rapidly in recent years.In the Chinese medicines such as ganoderma lucidum, cordyceps sinensis, pseudo-ginseng
In the cell, conventional medicine materical crude slice can only discharge part active ingredient when decocting for distribution mostly for active ingredient, active ingredient profit
With rate 10-30%；And broken wall crushing technology is used, the prepared slices of Chinese crude drugs are such as crushed to 300 mesh or so, cell-wall breaking ratio is up to
86.7%, the dissolution of active ingredient in medicinal material is improved, greatly enhances its drug effect, utilization rate of active components reaches more than 90%
To reduction medicinal material usage amount and protection herb resource, while it can also improve the quality increase drug effect of medicine.Because superfine formulation is thin
The increase of born of the same parents' sporoderm-broken rate, the product increase of broken wall dosage surface be present, it is in irregular shape, mobility, bad dispersibility, it is easy to moisture absorption, it is stable
Inherent characteristicses, the current processing methods such as property difference are that superfine disruption powder is pelletized, and improve the stability of product.Such as application number
For 201610596213.4 patent disclosure a kind of prepared slices of Chinese crude drugs ultrasonication method and its device, the prepared slices of Chinese crude drugs are which solved
Make the problem of medicine cost is high, but there is prepared slices of Chinese crude drugs raw material utilization efficiency is high, prepared slices of Chinese crude drugs raw material broken wall uniformity not
Height, prepared slices of Chinese crude drugs stability is bad, leaches slow-footed problem.
The content of the invention
The purpose of the present invention be overcome raw material utilization efficiency existing for the prepared slices of Chinese crude drugs such as existing ganoderma lucidum, cordyceps sinensis, pseudo-ginseng it is not high,
The problem of prepared slices of Chinese crude drugs raw material broken wall uniformity is not high, prepared slices of Chinese crude drugs stability is bad, there is provided one kind prepare cost it is low, production work
Skill is easy to grasp, prepared slices of Chinese crude drugs raw material broken wall uniformity is good, prepared slices of Chinese crude drugs stability is high, leaches the fireballing broken wall prepared slices of Chinese crude drugs
Preparation method.
The technical solution adopted for the present invention to solve the technical problems is：
A kind of preparation method of the broken wall prepared slices of Chinese crude drugs, it is characterised in that described preparation method comprises the following steps：
A. raw material selection：Fresh Chinese medicine material is taken, stem, the dust of leaf and Chinese medicine material surface, soil impurity is removed, obtains raw material；
B. dry：Raw material is used into vibrating dryer, it is 6-10% to dry to raw aqueous rate, the vibration frequency of vibrating dryer
For 32-36Hz, time of vibration 60-80s, 100-105 DEG C of drying temperature, dry raw material is obtained；
C. crush, sieve：Dry raw material is crushed, the screen cloth of 80-120 mesh is crossed after crushing, obtains raw material meal；
D. sterilize：Raw material meal, which is laid in sterilization box, is dried sterilization, and lay thickness is 10-20mm, sterilization temperature 60-
70 DEG C, sterilizing time 2-3h；
E. microorganism grows：In raw material meal movement to climatic chamber after sterilization, will control the temperature inside the box for 30-35 DEG C,
Relative humidity is 60-65%, maintains 10-12h, and rear adjustment temperature is 40-45 DEG C, relative humidity is that 75-80% maintains 10-20h；
F. re-pasteurization：Raw material meal after microorganism is grown, which is placed in sterilization box, carries out re-pasteurization, and sterilization temperature is
70-80 DEG C, sterilizing time 4-5h；
G. supersonic wave wall breaking：Raw material meal after re-pasteurization is subjected to supersonic wave wall breaking, the particle diameter after broken wall is 50-80 μm,
Broken wall fine powder is made；
H. ultra-fine grinding：Broken wall fine powder is placed in micronizer, 20-30min is crushed under the conditions of 16-24 DEG C, is crushed to
600-800 mesh, raw material superfine powder is made；
I. pelletize：By raw material superfine powder and auxiliary material by weight 100:15-18 is mixed, and is pelletized after well mixed, crosses 20-40 mesh sieves
Net is screened, and moisture content≤8% is dried to after screening, obtains medicine materical crude slice particle；
J. suppress, pack：Medicine materical crude slice particle is suppressed, the prepared slices of Chinese crude drugs are made, the prepared slices of Chinese crude drugs are packed, packaged
The prepared slices of Chinese crude drugs；
K. store：The packaged prepared slices of Chinese crude drugs are loaded in foil laminated film bag, after vacuumizing, is put into shady and cool storehouse and is store
Hide.
Auxiliary material in the step I is starch slurry, polyvinylpyrrolidone liquid, honey, syrup, maltose, xylitol, fruit juice
Or any one or more mixing in water.
Beneficial effect：The work that the present invention is crushed in broken wall prepared slices of Chinese crude drugs process using discontinuous sterilization, secondary broken wall
Skill is handled prepared slices of Chinese crude drugs raw material, improves the sterilization quality of prepared slices of Chinese crude drugs raw material, and secondary broken wall is crushed in can improving
The eduction rate of active component in medicine medicine materical crude slice raw material, the utilization rate of prepared slices of Chinese crude drugs raw material is improved, by the raw material after super fine crushing
Pelletized after being mixed with auxiliary material, make that prepared slices of Chinese crude drugs stability is good, it is fast to leach, nutriment speed of separating out is high, overcome existing broken wall
The problem of medicine materical crude slice indissoluble dissipates, absorptivity is low, stability is poor, improve the product quality of the broken wall prepared slices of Chinese crude drugs.
Embodiment
Embodiment one：
A kind of preparation method of the broken wall prepared slices of Chinese crude drugs, it is characterised in that described preparation method comprises the following steps：
A. raw material selection：Fresh Chinese medicine material is taken, stem, the dust of leaf and Chinese medicine material surface, soil impurity is removed, obtains raw material；
B. dry：Raw material is used into vibrating dryer, it is 8% to dry to raw aqueous rate, and the vibration frequency of vibrating dryer is
35Hz, time of vibration 70s, 104 DEG C of drying temperature, obtain dry raw material；
C. crush, sieve：Dry raw material is crushed, the screen cloth of 100 mesh is crossed after crushing, obtains raw material meal；
D. sterilize：Raw material meal, which is laid in sterilization box, is dried sterilization, and lay thickness is 15mm, and sterilization temperature is 65 DEG C,
Sterilizing time is 2.5h；
E. microorganism grows：In raw material meal movement to climatic chamber after sterilization, will control the temperature inside the box for 32 DEG C, it is relative
Humidity is 64%, maintains 11h, rear adjustment temperature is 42 DEG C, relative humidity is 78% maintenance 15h；
F. re-pasteurization：Raw material meal after microorganism is grown, which is placed in sterilization box, carries out re-pasteurization, and sterilization temperature is
75 DEG C, sterilizing time 5h；
G. supersonic wave wall breaking：Raw material meal after re-pasteurization is subjected to supersonic wave wall breaking, the particle diameter after broken wall is 60 μm, is made
Broken wall fine powder；
H. ultra-fine grinding：Broken wall fine powder is placed in micronizer, 25min is crushed under the conditions of 20 DEG C, is crushed to 700 mesh,
Raw material superfine powder is made；
I. pelletize：By raw material superfine powder and auxiliary material by weight 100:16 mixing, pelletize after well mixed, cross 30 eye mesh screens and carry out
Screening, is dried to moisture content≤8% after screening, obtains medicine materical crude slice particle；
J. suppress, pack：Medicine materical crude slice particle is suppressed, the prepared slices of Chinese crude drugs are made, the prepared slices of Chinese crude drugs are packed, packaged
The prepared slices of Chinese crude drugs；
K. store：The packaged prepared slices of Chinese crude drugs are loaded in foil laminated film bag, after vacuumizing, is put into shady and cool storehouse and is store
Hide.
Auxiliary material in the step I is starch slurry, honey is by weight 1:2 mixture.
Embodiment two：
A kind of preparation method of the broken wall prepared slices of Chinese crude drugs, it is characterised in that described preparation method comprises the following steps：
A. raw material selection：Fresh Chinese medicine material is taken, removes stem, the dust of leaf and Chinese medicine material surface, soil impurity, cuts 2cm section,
Obtain raw material；
B. dry：Raw material is used into vibrating dryer, it is 11% to dry to raw aqueous rate, and the vibration frequency of vibrating dryer is
38Hz, time of vibration 90s, 108 DEG C of drying temperature, obtain dry raw material；
C. crush, sieve：Dry raw material is crushed, the screen cloth of 150 mesh is crossed after crushing, obtains raw material meal；
D. sterilize：Raw material meal, which is laid in sterilization box, is dried sterilization, and lay thickness is 25mm, and sterilization temperature is 58 DEG C,
Sterilizing time is 3h；
E. microorganism grows：In raw material meal movement to climatic chamber after sterilization, will control the temperature inside the box for 36 DEG C, it is relative
Humidity is 69%, maintains 13h, rear adjustment temperature is 41 DEG C, relative humidity is 83% maintenance 16h；
F. re-pasteurization：Raw material meal after microorganism is grown, which is placed in sterilization box, carries out re-pasteurization, and sterilization temperature is
78 DEG C, sterilizing time 4h；
G. preliminary crushing：Raw material meal after re-pasteurization is crushed in room temperature and relative humidity in the environment of 45%,
Controlling operating pressure, for grader rotating speed in 30r/s, broken wall crushed 200 eye mesh screens in 0.8MPa, obtain just powder；
H. supersonic wave wall breaking：First powder is subjected to supersonic wave wall breaking, the particle diameter after broken wall is 90 μm, and broken wall fine powder is made；
I. ultra-fine grinding：Broken wall fine powder is placed in micronizer, 35min is crushed under the conditions of 27 DEG C, is crushed to 800 mesh,
Raw material superfine powder is made；
J. pelletize：By raw material superfine powder, auxiliary material, nostoc powder, okra juice by weight 100:14:1:1 mixing, is well mixed
After pelletize, cross 50 eye mesh screens screened, moisture content≤6% is dried to after screening, obtains medicine materical crude slice particle；
K. suppress, pack：Medicine materical crude slice particle is suppressed, the prepared slices of Chinese crude drugs are made, the prepared slices of Chinese crude drugs are packed, packaged
The prepared slices of Chinese crude drugs；
L. store：The packaged prepared slices of Chinese crude drugs are loaded in foil laminated film bag, after vacuumizing, is put into shady and cool storehouse and is store
Hide.
Auxiliary material in the step I is starch slurry, syrup, xylitol are by weight 2:1:1 mixture.
Embodiment three：
A kind of preparation method of the broken wall prepared slices of Chinese crude drugs, it is characterised in that described preparation method comprises the following steps：
A. raw material selection：Fresh Chinese medicine material is taken, removes stem, the dust of leaf and Chinese medicine material surface, soil impurity, being cut into thickness is
1cm piece, obtains raw material；
B. dry：Raw material is used into vibrating dryer, it is 5% to dry to raw aqueous rate, and the vibration frequency of vibrating dryer is
39Hz, time of vibration 100s, 97 DEG C of drying temperature, obtain dry raw material；
C. crush, sieve：Dry raw material is crushed, the screen cloth of 130 mesh is crossed after crushing, obtains raw material meal；
D. sterilize：Raw material meal, which is laid in sterilization box, is dried sterilization, and lay thickness is 25mm, and sterilization temperature is 75 DEG C,
Sterilizing time is 4h；
E. microorganism grows：Raw material meal after sterilization is packed, when temperature is 25 DEG C, sealed after water vapour is filled with into bag
Maintain 30h；
F. re-pasteurization：Raw material meal after microorganism is grown, which is placed in sterilization box, carries out re-pasteurization, and sterilization temperature is
85 DEG C, sterilizing time 6h；
G. supersonic wave wall breaking：Raw material meal after re-pasteurization is subjected to supersonic wave wall breaking, the particle diameter after broken wall is 90 μm, is made
Broken wall fine powder；
H. ultra-fine grinding：Broken wall fine powder is placed in micronizer, 40min is crushed under the conditions of 27 DEG C, is crushed to 900 mesh,
Raw material superfine powder is made；
I. pelletize：By raw material superfine powder and auxiliary material by weight 100:20 mixing, pelletize after well mixed, cross 60 eye mesh screens and carry out
Screening, is dried to moisture content≤7% after screening, obtains medicine materical crude slice particle；
J. suppress, pack：Medicine materical crude slice particle is suppressed, the prepared slices of Chinese crude drugs are made, the prepared slices of Chinese crude drugs are packed, packaged
The prepared slices of Chinese crude drugs；
K. store：The packaged prepared slices of Chinese crude drugs are loaded in foil laminated film bag, after vacuumizing, is put into shady and cool storehouse and is store
Hide.
The dimension life that auxiliary material in the step I is polyvinylpyrrolidone liquid, syrup, Cranberry Juice, mass fraction are 0.8%
Plain C solution presses 5:2:1:1 mixture.
Example IV：
A kind of preparation method of the broken wall prepared slices of Chinese crude drugs, it is characterised in that described preparation method comprises the following steps：
A. raw material selection：Fresh Chinese medicine material is taken, stem, the dust of leaf and Chinese medicine material surface, soil impurity is removed, obtains raw material；
B. dry：Raw material is used into vibrating dryer, it is 5% to dry to raw aqueous rate, and the vibration frequency of vibrating dryer is
40Hz, time of vibration 100s, 110 DEG C of drying temperature, obtain dry raw material；
C. crush, sieve：Dry raw material is crushed, the screen cloth of 100 mesh is crossed after crushing, obtains raw material meal；
D. sterilize：Raw material meal, which is laid in sterilization box, is dried sterilization, and lay thickness is 26mm, and sterilization temperature is 73 DEG C,
Sterilizing time is 4h；
E. microorganism grows：In raw material meal movement to climatic chamber after sterilization, will control the temperature inside the box for 37 DEG C, it is relative
Humidity is 59%, maintains 14h, rear adjustment temperature is 48 DEG C, relative humidity is 83% maintenance 23h；
F. re-pasteurization：Raw material meal after microorganism is grown, which is placed in sterilization box, carries out re-pasteurization, and sterilization temperature is
76 DEG C, sterilizing time 6h；
G. supersonic wave wall breaking：Raw material meal after re-pasteurization is subjected to supersonic wave wall breaking, the particle diameter after broken wall is 90 μm, is made
Broken wall fine powder；
H. ultra-fine grinding：Broken wall fine powder is placed in micronizer, 35min is crushed under the conditions of 28 DEG C, is crushed to 1000
Mesh, raw material superfine powder is made；
I. pelletize：By raw material superfine powder, auxiliary material, brewer's wort by weight 100:20:2 mixing, pelletize after well mixed, cross 60 mesh
Screen cloth is screened, and moisture content≤5% is dried to after screening, obtains medicine materical crude slice particle；
J. suppress, pack：Medicine materical crude slice particle is suppressed, the prepared slices of Chinese crude drugs are made, the prepared slices of Chinese crude drugs are packed, packaged
The prepared slices of Chinese crude drugs；
K. store：The packaged prepared slices of Chinese crude drugs are loaded in foil laminated film bag, after vacuumizing, is put into shady and cool storehouse and is store
Hide.
Auxiliary material in the step I is starch slurry, fructose syrup, honey, fruit juice press 2:1:2:2 mixture.
The present invention is exemplarily described above in conjunction with embodiment, it is clear that present invention specific implementation is not by above-mentioned side
The limitation of formula, if the improvement of the various unsubstantialities of inventive concept and technical scheme of the present invention progress is employed, or without
Improve and the design of the present invention and technical scheme are directly applied into other occasions, within protection scope of the present invention.This
Invention is not directed to partly same as the prior art or can realized using prior art.
Claims (2)
1. a kind of preparation method of the broken wall prepared slices of Chinese crude drugs, it is characterised in that described preparation method comprises the following steps：
A. raw material selection：Fresh Chinese medicine material is taken, stem, the dust of leaf and Chinese medicine material surface, soil impurity is removed, obtains raw material；
B. dry：Raw material is used into vibrating dryer, it is 6-10% to dry to raw aqueous rate, the vibration frequency of vibrating dryer
For 32-36Hz, time of vibration 60-80s, 100-105 DEG C of drying temperature, dry raw material is obtained；
C. crush, sieve：Dry raw material is crushed, the screen cloth of 80-120 mesh is crossed after crushing, obtains raw material meal；
D. sterilize：Raw material meal, which is laid in sterilization box, is dried sterilization, and lay thickness is 10-20mm, sterilization temperature 60-
70 DEG C, sterilizing time 2-3h；
E. microorganism grows：In raw material meal movement to climatic chamber after sterilization, will control the temperature inside the box for 30-35 DEG C,
Relative humidity is 60-65%, maintains 10-12h, and rear adjustment temperature is 40-45 DEG C, relative humidity is that 75-80% maintains 10-20h；
F. re-pasteurization：Raw material meal after microorganism is grown, which is placed in sterilization box, carries out re-pasteurization, and sterilization temperature is
70-80 DEG C, sterilizing time 4-5h；
G. supersonic wave wall breaking：Raw material meal after re-pasteurization is subjected to supersonic wave wall breaking, the particle diameter after broken wall is 50-80 μm,
Broken wall fine powder is made；
H. ultra-fine grinding：Broken wall fine powder is placed in micronizer, 20-30min is crushed under the conditions of 16-24 DEG C, is crushed to
600-800 mesh, raw material superfine powder is made；
I. pelletize：By raw material superfine powder and auxiliary material by weight 100:15-18 is mixed, and is pelletized after well mixed, crosses 20-40 mesh sieves
Net is screened, and moisture content≤8% is dried to after screening, obtains medicine materical crude slice particle；
J. suppress, pack：Medicine materical crude slice particle is suppressed, the prepared slices of Chinese crude drugs are made, the prepared slices of Chinese crude drugs are packed, packaged
The prepared slices of Chinese crude drugs；
K. store：The packaged prepared slices of Chinese crude drugs are loaded in foil laminated film bag, after vacuumizing, is put into shady and cool storehouse and is store
Hide.
2. the preparation method of the broken wall prepared slices of Chinese crude drugs according to claim 1, it is characterised in that the auxiliary material in the step I
It is mixed for any one or more in starch slurry, polyvinylpyrrolidone liquid, honey, syrup, maltose, xylitol, fruit juice or water
Close.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108671090A (en) * | 2018-05-24 | 2018-10-19 | 长沙小如信息科技有限公司 | A kind of preparation method of radix tetrastigme broken wall oral medicinal slice |
| CN108904444A (en) * | 2018-07-25 | 2018-11-30 | 建昌帮药业有限公司 | A method of preparing Chinese medicine wall cell disruption medicine materical crude slice suspension |
| CN110479463A (en) * | 2019-08-21 | 2019-11-22 | 贵州联盛药业有限公司 | The broken wall preparation method of the prepared slices of Chinese crude drugs |
| CN115463032A (en) * | 2022-09-16 | 2022-12-13 | 江阴市雨晨机械制造有限公司 | Efficient dissolving and mixing process |
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| CN108671090A (en) * | 2018-05-24 | 2018-10-19 | 长沙小如信息科技有限公司 | A kind of preparation method of radix tetrastigme broken wall oral medicinal slice |
| CN108904444A (en) * | 2018-07-25 | 2018-11-30 | 建昌帮药业有限公司 | A method of preparing Chinese medicine wall cell disruption medicine materical crude slice suspension |
| CN108904444B (en) * | 2018-07-25 | 2020-11-06 | 建昌帮药业有限公司 | Method for preparing traditional Chinese medicine wall-broken decoction piece suspension |
| CN110479463A (en) * | 2019-08-21 | 2019-11-22 | 贵州联盛药业有限公司 | The broken wall preparation method of the prepared slices of Chinese crude drugs |
| CN115463032A (en) * | 2022-09-16 | 2022-12-13 | 江阴市雨晨机械制造有限公司 | Efficient dissolving and mixing process |
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Application publication date: 20171208 |