CN106237068A

CN106237068A - A kind of pharmaceutical composition improving yin-deficiency constitution and a kind of medicine brick and preparation method thereof

Info

Publication number: CN106237068A
Application number: CN201610779644.4A
Authority: CN
Inventors: 谢浩峰; 边宝林; 张长平; 白国栋
Original assignee: Individual
Current assignee: Individual
Priority date: 2016-08-30
Filing date: 2016-08-30
Publication date: 2016-12-21

Abstract

The invention provides the pharmaceutical composition improving yin-deficiency constitution, described compositions includes following components by weight: Fructus Corni 40 80 parts, Rhizoma dioscoreae 100 140 parts, 40 80 parts of Radix Rehmanniae Preparata, Rhizoma Alismatis 40 80 parts, Radix Rehmanniae Preparata 30 70 parts, stir-baked RHIZOMA ANEMARRHENAE before sprinking salt solution 10 50 parts, stir-baked CORTEX PHELLODENDRI with salt solution 40 80 parts, vinegar Carapax Et Plastrum Testudinis 40 80 parts, Medulla Sus domestica 10 50 parts, Semen Cuscutae 40 80 parts, Radix Achyranthis Bidentatae 40 80 parts, Colla Plastri Testudinis 30 70 parts, Colla cornus cervi 30 70 parts, Fructus Corni 40 80 parts, Fructus Lycii 40 80 parts, Radix Angelicae Sinensis 60 100 parts, the Radix Astragali 100 140 parts, Rhizoma Chuanxiong 60 100 parts, Radix Paeoniae Rubra 60 100 parts, Radix Scrophulariae 40 80 parts, Radix Ophiopogonis 40 80 parts.Present invention also offers for medicine brick improving yin-deficiency constitution and preparation method thereof, described medicine brick is mainly made up of described pharmaceutical composition and loess.

Description

A kind of pharmaceutical composition improving yin-deficiency constitution and a kind of medicine brick and preparation method thereof

Technical field

The present invention relates to the field of Chinese medicines, in particular to a kind of pharmaceutical composition improving yin-deficiency constitution and a kind of medicine Brick and preparation method thereof.

Background technology

Yin-deficiency constitution is owing to the cloudy liquid such as internal body fluid essence and blood lose few, shows as the body constitution of principal character with yin asthenia generating intrinsic heat etc. State." element hears regulating menstruation opinion ": " deficiency of YIN bringing about interior heat." unit's Zhu Zhenheng " Further Discourses on the Properties of Things ": " thin body's fire is many.”

"guide to clinical practice with medical record": " thin body's deficiency of YIN." " the long special edition of gold ": " the thin point of shape is long, and color of the leather is wan and sallow, deficiency of YIN wood fire Undoubtedly." cloudy liquid loses few, body loses nourishings that make moist, therefore the bodily form is tall and thin, usually easy dryness of the mouth and throat, and nose is micro-to be done, and is hard and dry, little The shortest, vertigo and tinnitus, two dryness and uneasy feeling of the eye, blurred vision, skin is the most dry, easily gives birth to wrinkle, the few tongue in the few Tianjin of tongue, thready pulse；Simultaneously because it is cloudy Sun the most processed, the gas phase of sun heat to the most prosperous and give birth to interior-heat, therefore the syndrome disturbed in showing as one asthenic fire, it is seen that feverish sensation in the palms and soles, thirsty Desire for cold drinks, flushed face, warm sense, red lip is micro-dry, sleeps poor, red tongue rapid pulse etc..

Treat the deficiency of YIN, many employing herbal fomentation therapies by topical agent, utilize hot towel, hot water bag or there is heating The therapeutic equipments of effect, by middle drug application at people's body surface, by the dual function of medicine Yu hot compress, alleviates, treats cold body constitution. Herbal fomentation therapy is exactly the physiological property utilizing skin, makes medicine be turned by skin surface absorption, stratum corneum penetration and corium Transport and play pharmacodynamics effect into blood circulation.Herbal fomentation has concentrated traditional Chinese medical science medication, thermotherapy, tcm herbal ion osmotic therapeutic therapy Deng several functions, melt temperature, humidity, drug level in one, due to illness treat, medicine suit the medicine to the illness, can effectively treat multiple disease.Directly Connect and Chinese medicine is heated, eliminate traditional that needs and first Chinese medicine decocting is cooked into liquid cumbersome process, by by the most not Disconnected medicine of a warm nature molecule directly acts on human body, expansion blood vessel locally and systemically in the way of convection current and infiltration, promotes body surface group The blood circulation knitted, improves the Absorption of skin, promotes a large amount of secretions of sweat gland, accelerates the metabolism of skin；Simultaneously by In fomentation medicine effusion Chinese medicine particle (for molecule or ion) act on body surface directly produce acaricide, parasite killing, sterilization, antiinflammatory, Antipruritic, control pain etc. effect, or transdermal absorption human body by excite histiocyte receptor Biochemical processes play medication make With, and then eliminate focus.

But, the herbal fomentation therapy in correlation technique, owing to Chinese medicine needs and the dermal contact of patient, but also need Medical personnel or patient hand-held towel, hot water bag or there is the therapeutic equipments of heat effect, to the position being covered with Chinese medicine Heating, so, it is not easy to medical personnel or patient's operation.It is therefore desirable to have novel hot compress therapy solves the problems referred to above.

Reporting in prior art and use health-preserving heated brick bed as medical apparatus and instruments, in heated kang, the medicine group of medicine brick is made in heating Compound, when being administered in this way, medicine brick meeting releasing Chinese medicine particle (for molecule or ion) after heating, thus inhale through transdermal Take in human body, excite the effect of the Biochemical processes volatilization medication of histiocyte receptor, and then reach to treat affected part Purpose.This way it is not necessary to the affected part of patient is carried out by medical personnel or the hand-held firing equipment of patient.

But, add the mode difference of medicine of a warm nature brick administration very owing to being conventionally used for herbal fomentation therapy with employing health-preserving heated brick bed Greatly, in order to adapt to different administering modes, need one can prepare patent medicine brick, and be well adapted for heating this administration of administration The compositions of mode, it the most also needs to have good drug effect concurrently.

In view of this, the present invention is proposed.

Summary of the invention

The first object of the present invention is to provide a kind of pharmaceutical composition improving yin-deficiency constitution, described pharmaceutical composition Can effectively improve yin-deficiency constitution, and adapt to the administering mode of heating topical administration especially；

The second object of the present invention is to provide a kind of medicine brick, and described medicine brick is mixed system by described pharmaceutical composition with loess Standby, it is possible to discharge pharmaceutically active substance by heating well, reach therapeutic effect；

The third object of the present invention is to provide the preparation method of described medicine brick, and described method process is clear and definite, it is easy to Control, favorable reproducibility.

In order to realize the above-mentioned purpose of the present invention, spy by the following technical solutions:

One aspect of the present invention relates to a kind of pharmaceutical composition improving yin-deficiency constitution, and described compositions includes by weight The following components of part meter:

Fructus Corni 40-80 part, Rhizoma dioscoreae 100-140 part, Radix Rehmanniae Preparata 40-80 part, Rhizoma Alismatis 40-80 part, Radix Rehmanniae Preparata 30-70 part, Stir-baked RHIZOMA ANEMARRHENAE before sprinking salt solution 10-50 part, stir-baked CORTEX PHELLODENDRI with salt solution 40-80 part, vinegar Carapax Et Plastrum Testudinis 40-80 part, Medulla Sus domestica 10-50 part, Semen Cuscutae 40-80 part, Radix Achyranthis Bidentatae 40- 80 parts, Colla Plastri Testudinis 30-70 part, Colla cornus cervi 30-70 part, Fructus Corni 40-80 part, Fructus Lycii 40-80 part, Radix Angelicae Sinensis 60-100 part, the Radix Astragali 100-140 part, Rhizoma Chuanxiong 60-100 part, Radix Paeoniae Rubra 60-100 part, Radix Scrophulariae 40-80 part, 40-80 part Radix Ophiopogonis.

Radix Rehmanniae Preparata, Fructus Corni, Rhizoma Dioscoreae, Rhizoma Alismatis, Cortex Moutan, Poria is used in combination has good effect, can reach The three cloudy effects with benefit (tonifying kidney-yin, tonifying liver the moon, tonifying spleen-yin), Radix Rehmanniae Preparata can be with tonifying kidney-yin；Fructus Corni is then that Liver and kidney is same to be mended, and passes through Tonifying liver reaches the purpose of the kidney invigorating；Rhizoma Dioscoreae energy tonifying speen and tonifying kidney, mends the day after tomorrow by spleen invigorating, and it has and significantly strengthens immunity, anti- Aging, resisting fatigue, low-temperature resistance, anoxia enduring, blood fat reducing, blood pressure lowering, blood sugar lowering, improve renal function, enhance metabolism and stronger Strong effect.

Radix Rehmanniae Preparata, the Rhizoma Anemarrhenae, Cortex Phellodendri, Carapax Et Plastrum Testudinis, Medulla Sus domestica is used in combination also has good effect, for deficiency of YIN fire Prosperous, hectic fever night sweat, cough spitting of blood, tinnitus seminal emission, it is reused Radix Rehmanniae Preparata, Carapax et Plastrum Testudinis nourishing YIN for suppressing the hyperactive YANG, strengthens water system fire, be monarch drug altogether.Cortex Phellodendri, Rhizoma Anemarrhenae mutual reinforcement between is use, bitter cold pathogenic fire reducing, preserves cloudy liquid, its yang hyperactivity flat, is ministerial drug.Application Medulla Sus domestica, Mel are ball, and ratio is flesh and blood The product of sweet profit, can nourish marrow, and the hardship that can restrict again Cortex Phellodendri is dry, all make for assistant.All medicines share, and YIN nourishing is smart and drops fire mutually, with Reach the effect that reinforcing is radically reformed.Between these several components, drugs for nourishing yin matches with resolving heat and reducing pathogenic fire medicine, and reinforcing is radically reformed, and both take into account.Wherein Radix Rehmanniae Preparata Heavier with the consumption of Carapax et Plastrum Testudinis, with know, the ratio of cypress is three to two, is shown to be based on YIN nourishing reinforcing, pathogenic fire reducing is radically reformed as secondary.For Syndrome of hyperactivity of fire due to deficiency of YIN, if only YIN nourishing and not pathogenic fire reducing, then asthenic fire is difficult clear；If only pathogenic fire reducing and non-YIN nourishing, even if the intensity of a fire is lulled, still the most multiple Sprout, therefore must YIN nourishing share with pathogenic fire reducing, can be satisfactory to both parties.

Additionally, cherish greatly Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Fructus Lycii, Fructus Corni, Radix Cyathulae, Colla cornus cervi, Colla Plastri Testudinis, Semen Cuscutae compatibility, Ke Yizhi Treat kidney-YIN being deficient, have a dizzy spell, waist soreness, lingering diarrhea of passing out semen, spontaneous sweating, dry mouth dry tongue, the few tongue of red tongue, thready pulse.We are often Belonging to deficiency of kidney yin for alzheimer disease, climacteric syndrome, senile osteoporosis, amenorrhea, Hypomenorrhea etc., marrow loses Void person.

Preferably, described compositions includes following components by weight:

Fructus Corni 50-70 part, Rhizoma dioscoreae 90-130 part, Radix Rehmanniae Preparata 50-70 part, Rhizoma Alismatis 50-70 part, Radix Rehmanniae Preparata 40-60 part, salt Rhizoma Anemarrhenae 20-40 part, stir-baked CORTEX PHELLODENDRI with salt solution 50-70 part, vinegar Carapax Et Plastrum Testudinis 50-70 part, pig ridge 20-40 part, Semen Cuscutae 50-70 part, Radix Achyranthis Bidentatae 50-70 Part, Colla Plastri Testudinis 40-60 part, Colla cornus cervi 40-60 part, Fructus Corni 50-70 part, Fructus Lycii 50-70 part, Radix Angelicae Sinensis 70-90 part, Radix Astragali 110- 130 parts, Rhizoma Chuanxiong 70-90 part, Radix Paeoniae Rubra 70-90 part, Radix Scrophulariae 50-70 part, 50-70 part Radix Ophiopogonis.

Preferably, described compositions also includes accessory drugs, it is preferable that described accessory drugs includes following components by weight:

Herba Artemisiae Annuae 110-130 part, Cortex Lycii 70-90 part, Radix Aucklandiae 140-160 part, Fructus Amomi 50-70 part, Pericarpium Citri Reticulatae 70-90 part, chicken Endothelium corneum 50-70 part, Semen Ziziphi Spinosae 140-160 part, Radix Polygalae 90-110 part, Cortex Albiziae 50-70 part, Poria 140-160 part, Cortex Moutan 90- 110 parts.

Herba Artemisiae Annuae, bitter, pungent, cold.Return liver, gallbladder meridian, three burnt, kidney channels.Clear deficiency-heat, removing heat from blood is except steaming, expelling summer-heat, preventing the attack (or recurrence) of malaria.For summer-heat Evil heating, fever due to yin deficiency, night fever abating at dawn, hectic fever due to YIN-deficiency consumptive fever, malaria cold and heat, jaundice due to damp-heat.This product clearing up internal heat by using drugs of bitter in taste and cold in nature, pungent perfume (or spice) dissipates thoroughly, kind Make a cloudy point latent heat thoroughly reach outer dissipating, for fever due to yin deficiency key medicine, have expelling summer-heat in addition concurrently, cut cruel merit.

Cortex Moutan, cold in nature, bitter in the mouth；Cool；It is slightly cold.GUIXIN；Liver；Kidney；Function clearing away heat and cooling blood；Promoting blood circulation to remove blood stasis.Cure mainly: warm febrile disease Enter blood system；Send out speckle；Tell nosebleed；Pathogenic bacteria later stage hot Fu Yin brimful of tears distributes heat；Deficiency of YIN osteopyrexia and fever；Amenorrhea due to stagnation of blood；Dysmenorrhea；Carbuncle Sore；Fall and flutter the pain of injury；Beriberoid pyretic arthralgia.Have that lung meridian is calm, cooling, antipyretic, analgesia, central inhibitory action and the anti-tremulous pulse such as spasmolytic The effects such as atherosis, diuresis, antiulcer.

Fructus Amomi, pungent, temperature.Enter spleen, stomach warp.Mainly acting on the stomach of human body, kidney and spleen, it is possible to circulation of qi promoting seasoning, stomach function regulating is amusing. Fructus Amomi often coordinates with Cortex Magnoliae Officinalis, Fructus Aurantii Immaturus, Pericarpium Citri Reticulatae etc., is suitable for treating the disease such as fullness in the epigastrium and chest, abdominal distention and little diet.In feasible controlled atmosphere, and Stomach, is amusing.Control stomachache painful abdominal mass swollen, anorexia dyspepsia, dysphagic vomiting, diarrhea due to cold pathogen cold-dysentery, gestation fetal movement.Document about Fructus Amomi effect is recorded As follows.

Pericarpium Citri Reticulatae, bitter in the mouth, pungent, warm in nature.Return lung, spleen channel.Regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.

Endothelium Corneum Gigeriae Galli, sweet, flat.Return spleen, stomach, small intestinal, bladder warp.Invigorating the stomach and promoting digestion, arresting seminal emission, treating stranguria fossil.For food stagnation Do not disappear, vomiting dysentery, infantile malnutrition, the enuresis, seminal emission, the puckery pain of stranguria caused by urinary stone, gallbladder-distention hypochondriac pain.

Poria, sweet in the mouth, light, property is put down.GUIXIN, lung, spleen, kidney channel.Promoting diuresis to eliminate damp pathogen, spleen invigorating, mind calming.For edema oliguria, expectorant Drinking vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability, palpitation with fear insomnia.

Semen Ziziphi Spinosae, nature and flavor: sweet are flat.GUIXIN warp；Spleen channel；Liver Channel；Gallbladder meridian.Mind tranquilizing and the heart calming；Nourishing the liver；Arresting sweating.Cure mainly fidgets due to deficiency not Sleep；Palpitation with fear palpitation with a distress feeling；Body void spontaneous perspiration, night sweat.Control restlessness of asrhenia type and insomnia, palpitation with a distress feeling of palpitating with fear, excessive thirst, sweating due to debility.

Radix Polygalae, bitter, pungent, warm.GUIXIN, kidney, lung meridian.There is Fructus Alpiniae Oxyphyllae of calming the nerves, the function eliminated the phlegm, subside a swelling, for disarmony between the heart and kidney The insomnia and dreamful sleep caused, forgetful palpitation with fear, staring spells, expectoration is not well, sore swollen toxin, breast swell and pain.

Cortex Albiziae, nature and flavor are sweet, flat.There are resolving depression and blood, mind calming, the merit of subduing inflammation.Control irritability, melancholy, insomnia, Lung abscess, carbuncle, scrofula, the effect of injured bone.

Another aspect of the present invention relates to a kind of medicine brick for improving yin-deficiency constitution, and described medicine brick is mainly by described Pharmaceutical composition and loess are made.

Loess can organically combine with Chinese herbal medicine and various mineral, in loess containing to the useful boron of the person, iodine, 30 various trace elements such as zinc, selenium, copper, magnesium, calcium, play defying age, anticancer change, maintain the stability of cell membrane, raising immunity Function, then with the combination of Chinese herbal medicine and various mineral after, the health maintenance effect of product is greatly improved.

Preferably, the weight ratio of described loess and described pharmaceutical composition is: (0.5-2): 1.

Another aspect of the present invention relates to the preparation method of described medicine brick, said method comprising the steps of:

1) Radix Astragali, Radix Angelicae Sinensis boiling are obtained blood-enriching soup；Radix Scrophulariae, boiling Radix Ophiopogonis are obtained Zengye Tang；

2) described blood-enriching soup and Zengye Tang are mixed and concentrating under reduced pressure obtains middle concentrated solution；

3) continue to concentrate in described middle concentrated solution is placed in jacketed pan, obtain final concentrated solution；

4) by Fructus Corni, Rhizoma dioscoreae, Radix Rehmanniae Preparata, Rhizoma Alismatis, Radix Rehmanniae Preparata, stir-baked RHIZOMA ANEMARRHENAE before sprinking salt solution, stir-baked CORTEX PHELLODENDRI with salt solution, vinegar Carapax Et Plastrum Testudinis, pig ridge, Semen Cuscutae, Radix Achyranthis Bidentatae, Colla Plastri Testudinis, Colla cornus cervi, Fructus Corni, Fructus Lycii, Rhizoma Chuanxiong, Radix Paeoniae Rubra, be respectively prepared decoction pieces, after pulverizing and mixing, and with described Whole concentrated solution and loess are mixed to prepare mixture；

5) by described mixture punch forming drying and shaping, finished medicines brick is prepared.

The Radix Astragali, Radix Angelicae Sinensis boiling can be obtained Radix Angelicae Sinensis decoction for tonifying blood, qi-supplementing, blood-engendering.Blood deficiency sun floating heating card.Flesh hot side Red, tired thist with desire to drink, full and large pulse and empty, heavily press unable.Also married woman menstrual period, fever due to deficiency of blood headache in puerperal are controlled；Or after skin infection is burst, the most not Healing person.For tonifying recipes, there is the effect enriched blood.Cure mainly blood deficiency sun floating heating card.Flesh hot side is red, tired thist with desire to drink, full and large pulse and Void, heavily by unable.Also married woman menstrual period, fever due to deficiency of blood headache in puerperal are controlled；Or after skin infection is burst, long disunion person.Clinic is usually used in controlling Treat the stagnation of heart-blood persons such as angina pectoris；The blood deficiency sun persons of floating such as married woman menstrual period, puerperal fever；Various anemias, anaphylactoid purpura Hot person is had etc. blood deficiency.

Radix Scrophulariae, boiling Radix Ophiopogonis be can get Zengye Tang, and it has increasing liquid and moisturizes.The bright epidemic febrile disease of sun, body fluid deficiency constipation is demonstrate,proved.Greatly Constipation is tied, and thirsty, dry tongue is red, thready and rapid pulse or heavy and unable effect.

By the specific components in decocting pharmaceutical composition, can obtain for treating the decoction of the deficiency of YIN in Chinese medicine, The synergistic function between each component can be given full play to after the ground product of itself and other component and loess mixing, and obtain spy It is not suitable for the medicine brick of the heating administering mode of health-preserving heated brick bed.

Preferably, the step 4 of described method) in, by Herba Artemisiae Annuae, Cortex Lycii, the Radix Aucklandiae, Fructus Amomi, Pericarpium Citri Reticulatae, Endothelium Corneum Gigeriae Galli, Semen Ziziphi Spinosae, Radix Polygalae, Cortex Albiziae, Poria, Cortex Moutan are also respectively prepared after decoction pieces and pulverize, and mix with the decoction pieces ground product of other components, and together with Described final concentrated solution is mixed to prepare mixture.

Preferably, described middle concentrated solution, the relative density when 50 DEG C is 1.05-1.08g/cm³；Described final concentration The liquid relative density when 50 DEG C is 1.30-1.35g/cm³。

By decoction is concentrated, can be so that the mixing of its other components with powder in subsequent step.

Preferably, described step 1) in, decocting and carry out twice, the weight every time adding water is to treat decocting herbs gross weight 8-12 times, each decocting time is 50-70min, and after decocting, filtrate crosses 300 mesh sieves every time.

Some components of decocting drug regimen species, can be beneficial to extract the effective ingredient in medical material, and it is had Evil composition filters with medicinal residues.

Preferably, described step 5) in, the pressing time in punching course is 2-3min, dries temperature and is 40-45 DEG C, excellent Selection of land, baking duration is 1.5-2.5h.

Compared with prior art, the invention have the benefit that

(1) the compound forward osmosis membrane of the present invention, has antibacterial functions；

(2) the compound forward osmosis membrane of the present invention, can be effectively improved water flux, and reach the highest salt-stopping rate；

(3) preparation method of the present invention is reliable and stable, and used process detail is particularly suitable for preparing described being combined and just permeates Film.

Detailed description of the invention

Below in conjunction with embodiment, embodiment of the present invention are described in detail, but those skilled in the art will Understanding, the following example is merely to illustrate the present invention, and is not construed as limiting the scope of the present invention.In embodiment unreceipted specifically Condition person, the condition advised according to normal condition or manufacturer is carried out.Agents useful for same or instrument unreceipted production firm person, be Can be by the commercially available conventional products bought and obtain.

Embodiment 1

Prepare the medicine brick for treating yin-deficiency constitution in accordance with the following steps

1. prepare following raw material by weight and the loess of medical material gross weight 0.5 times amount

Fructus Corni 40 parts, Rhizoma dioscoreae 100 parts, 40 parts of Radix Rehmanniae Preparata, Rhizoma Alismatis 40 parts, Radix Rehmanniae Preparata 30 parts, stir-baked RHIZOMA ANEMARRHENAE before sprinking salt solution 10 parts, stir-baked CORTEX PHELLODENDRI with salt solution 40 parts, vinegar Carapax Et Plastrum Testudinis 40 parts, Medulla Sus domestica 10 parts, Semen Cuscutae 40 parts, Radix Achyranthis Bidentatae 40 parts, Colla Plastri Testudinis 30 parts, Colla cornus cervi 30 parts, Fructus Corni 40 Part, Fructus Lycii 40 parts, Radix Angelicae Sinensis 60 parts, the Radix Astragali 100 parts, Rhizoma Chuanxiong 60 parts, Radix Paeoniae Rubra 60 parts, Radix Scrophulariae 40 parts, Radix Ophiopogonis 40 parts.

2. the Radix Astragali, Radix Angelicae Sinensis boiling are obtained blood-enriching soup；Radix Scrophulariae, boiling Radix Ophiopogonis are obtained Zengye Tang；Decoction is carried out Twice, the weight every time adding water is treat decocting herbs gross weight 8 times, and each decocting time is 50min, filters after decocting every time Liquid crosses 300 mesh sieves.

3. described blood-enriching soup and Zengye Tang are mixed and concentrating under reduced pressure obtains concentrated solution in the middle of described in middle concentrated solution, at 50 DEG C Time relative density be 1.05g/cm³；

4. continuing to concentrate in described middle concentrated solution is placed in jacketed pan, obtain final concentrated solution, described final concentrated solution exists Relative density when 50 DEG C is 1.30g/cm³；

5. by Fructus Corni, Rhizoma dioscoreae, Radix Rehmanniae Preparata, Rhizoma Alismatis, Radix Rehmanniae Preparata, stir-baked RHIZOMA ANEMARRHENAE before sprinking salt solution, stir-baked CORTEX PHELLODENDRI with salt solution, vinegar Carapax Et Plastrum Testudinis, Medulla Sus domestica, Herba cuscutae Son, Radix Achyranthis Bidentatae, Colla Plastri Testudinis, Colla cornus cervi, Fructus Corni, Fructus Lycii, Rhizoma Chuanxiong, Radix Paeoniae Rubra, be respectively prepared decoction pieces, after pulverizing and mixing, and with institute State final concentrated solution and be mixed to prepare mixture；

6., by described mixture punch forming drying and shaping, prepare finished medicines brick, wherein, during pressurization in punching course Between be 2min, dry temperature be 40 DEG C, baking duration is 1.5h.

Embodiment 2

1. prepare following raw material by weight and the loess of medical material gross weight 2 times amount

Fructus Corni 80 parts, Rhizoma dioscoreae 140 parts, 80 parts of Radix Rehmanniae Preparata, Rhizoma Alismatis 80 parts, Radix Rehmanniae Preparata 30-70 part, stir-baked RHIZOMA ANEMARRHENAE before sprinking salt solution 50 parts, salt Cortex Phellodendri 80 parts, vinegar Carapax Et Plastrum Testudinis 80 parts, Medulla Sus domestica 50 parts, Semen Cuscutae 80 parts, Radix Achyranthis Bidentatae 80 parts, Colla Plastri Testudinis 70 parts, Colla cornus cervi 70 parts, mountain Zhu Cornel 80 parts, Fructus Lycii 80 parts, Radix Angelicae Sinensis 100 parts, the Radix Astragali 140 parts, Rhizoma Chuanxiong 100 parts, Radix Paeoniae Rubra 100 parts, Radix Scrophulariae 80 parts, Radix Ophiopogonis 80 parts.

2. the Radix Astragali, Radix Angelicae Sinensis boiling are obtained blood-enriching soup；Radix Scrophulariae, boiling Radix Ophiopogonis are obtained Zengye Tang；Decoction is carried out Twice, the weight every time adding water is treat decocting herbs gross weight 12 times, and each decocting time is 70min, after decocting every time Filtrate crosses 300 mesh sieves.

3. described blood-enriching soup and Zengye Tang are mixed and concentrating under reduced pressure obtains concentrated solution in the middle of described in middle concentrated solution, at 50 DEG C Time relative density be 1.08g/cm³；

4. continuing to concentrate in described middle concentrated solution is placed in jacketed pan, obtain final concentrated solution, described final concentrated solution exists Relative density when 50 DEG C is 1.35g/cm³；

6., by described mixture punch forming drying and shaping, prepare finished medicines brick, wherein, during pressurization in punching course Between be 3min, dry temperature be 45 DEG C, baking duration is 2.5h.

Embodiment 3

Prepare the medicine brick for treating yin-deficiency constitution and the loess of medical material gross weight 1.5 times amount in accordance with the following steps

1. prepare following raw material by weight and medical material gross weight ... loess

Fructus Corni 50 parts, Rhizoma dioscoreae 90 parts, 50 parts of Radix Rehmanniae Preparata, Rhizoma Alismatis 50 parts, Radix Rehmanniae Preparata 40 parts, stir-baked RHIZOMA ANEMARRHENAE before sprinking salt solution 20 parts, stir-baked CORTEX PHELLODENDRI with salt solution 50 parts, vinegar Carapax Et Plastrum Testudinis 50 parts, Medulla Sus domestica 20 parts, Semen Cuscutae 50 parts, Radix Achyranthis Bidentatae 50 parts, Colla Plastri Testudinis 40 parts, Colla cornus cervi 40 parts, Fructus Corni 50 Part, Fructus Lycii 50 parts, Radix Angelicae Sinensis 70 parts, the Radix Astragali 110 parts, Rhizoma Chuanxiong 70 parts, Radix Paeoniae Rubra 70 parts, Radix Scrophulariae 50 parts, Radix Ophiopogonis 50 parts, Herba Artemisiae Annuae 110 parts, Cortex Lycii 70 parts, the Radix Aucklandiae 140 parts, Fructus Amomi 50 parts, Pericarpium Citri Reticulatae 70 parts, Endothelium Corneum Gigeriae Galli 50 parts, Semen Ziziphi Spinosae 140 parts, Radix Polygalae 90 parts, Cortex Albiziae 50 parts, 140 parts of Poria, Cortex Moutan 90 parts.

5. by Fructus Corni, Rhizoma dioscoreae, Radix Rehmanniae Preparata, Rhizoma Alismatis, Radix Rehmanniae Preparata, stir-baked RHIZOMA ANEMARRHENAE before sprinking salt solution, stir-baked CORTEX PHELLODENDRI with salt solution, vinegar Carapax Et Plastrum Testudinis, Medulla Sus domestica, Herba cuscutae Son, Radix Achyranthis Bidentatae, Colla Plastri Testudinis, Colla cornus cervi, Fructus Corni, Fructus Lycii, Rhizoma Chuanxiong, Radix Paeoniae Rubra, by Herba Artemisiae Annuae, Cortex Lycii, the Radix Aucklandiae, Fructus Amomi, Pericarpium Citri Reticulatae, chicken Gold, Semen Ziziphi Spinosae, Radix Polygalae, Cortex Albiziae, Poria, Cortex Moutan are respectively prepared decoction pieces, after pulverizing and mixing, and mix with described final concentrated solution Close and prepare mixture；

Embodiment 4

1. prepare following raw material by weight and the loess of medical material gross weight 1 times amount

Fructus Corni 70 parts, Rhizoma dioscoreae 130 parts, 70 parts of Radix Rehmanniae Preparata, Rhizoma Alismatis 70 parts, Radix Rehmanniae Preparata 60 parts, stir-baked RHIZOMA ANEMARRHENAE before sprinking salt solution 40 parts, stir-baked CORTEX PHELLODENDRI with salt solution 70 parts, vinegar Carapax Et Plastrum Testudinis 70 parts, Medulla Sus domestica 40 parts, Semen Cuscutae 70 parts, Radix Achyranthis Bidentatae 70 parts, Colla Plastri Testudinis 60 parts, Colla cornus cervi 60 parts, Fructus Corni 70 Part, Fructus Lycii 70 parts, Radix Angelicae Sinensis 90 parts, the Radix Astragali 130 parts, Rhizoma Chuanxiong 90 parts, Radix Paeoniae Rubra 90 parts, Radix Scrophulariae 70 parts, Radix Ophiopogonis 70 parts, Herba Artemisiae Annuae 130 parts, Cortex Lycii 90 parts, the Radix Aucklandiae 160 parts, Fructus Amomi 70 parts, Pericarpium Citri Reticulatae 90 parts, Endothelium Corneum Gigeriae Galli 70 parts, Semen Ziziphi Spinosae 160 parts, Radix Polygalae 110 parts, Herba Albiziae Skin 70 parts, 160 parts of Poria, Cortex Moutan 110 parts.

2. the Radix Astragali, Radix Angelicae Sinensis boiling are obtained blood-enriching soup；Radix Scrophulariae, boiling Radix Ophiopogonis are obtained Zengye Tang；Decoction is carried out Twice, the weight every time adding water is treat decocting herbs gross weight 10 times, and each decocting time is 65min, after decocting every time Filtrate crosses 300 mesh sieves.

3. described blood-enriching soup and Zengye Tang are mixed and concentrating under reduced pressure obtains concentrated solution in the middle of described in middle concentrated solution, at 50 DEG C Time relative density be 1.07g/cm³；

4. continuing to concentrate in described middle concentrated solution is placed in jacketed pan, obtain final concentrated solution, described final concentrated solution exists Relative density when 50 DEG C is 1.33g/cm³；

5. by Fructus Corni, Rhizoma dioscoreae, Radix Rehmanniae Preparata, Rhizoma Alismatis, Radix Rehmanniae Preparata, stir-baked RHIZOMA ANEMARRHENAE before sprinking salt solution, stir-baked CORTEX PHELLODENDRI with salt solution, vinegar Carapax Et Plastrum Testudinis, Medulla Sus domestica, Herba cuscutae In son, Radix Achyranthis Bidentatae, Colla Plastri Testudinis, Colla cornus cervi, Fructus Corni, Fructus Lycii, Rhizoma Chuanxiong, Radix Paeoniae Rubra, Herba Artemisiae Annuae, Cortex Lycii, the Radix Aucklandiae, Fructus Amomi, Pericarpium Citri Reticulatae, chicken Gold, Semen Ziziphi Spinosae, Radix Polygalae, Cortex Albiziae, Poria, Cortex Moutan are respectively prepared decoction pieces, after pulverizing and mixing, and mix with described final concentrated solution Close and prepare mixture；

6., by described mixture punch forming drying and shaping, prepare finished medicines brick, wherein, during pressurization in punching course Between be 2min, dry temperature be 42 DEG C, baking duration is 1.5h.

Embodiment 5

Fructus Corni 60 parts, Rhizoma dioscoreae 120 parts, 60 parts of Radix Rehmanniae Preparata, 150 parts of Poria, Cortex Moutan 100 parts, Rhizoma Alismatis 60 parts, Radix Rehmanniae Preparata 50 Part, stir-baked RHIZOMA ANEMARRHENAE before sprinking salt solution 30 parts, stir-baked CORTEX PHELLODENDRI with salt solution 60 parts, vinegar Carapax Et Plastrum Testudinis 60 parts, 30 parts of pig ridge, Semen Cuscutae 60 parts, Radix Achyranthis Bidentatae 60 parts, Colla Plastri Testudinis 50 parts, Colla cornus cervi 50 parts, Fructus Corni 60 parts, Fructus Lycii 60 parts, Radix Angelicae Sinensis 80 parts, the Radix Astragali 120 parts, Rhizoma Chuanxiong 80 parts, Radix Paeoniae Rubra 80 parts, Radix Scrophulariae 60 parts, Radix Ophiopogonis 60 parts, Herba Artemisiae Annuae 120 parts, Cortex Lycii 80 parts, the Radix Aucklandiae 150 parts, Fructus Amomi 60 parts, Pericarpium Citri Reticulatae 80 parts, Endothelium Corneum Gigeriae Galli 60 parts, Semen Ziziphi Spinosae 150 parts, Radix Polygalae 100 parts, Cortex Albiziae 60 parts.

3. described blood-enriching soup and Zengye Tang are mixed and concentrating under reduced pressure obtains concentrated solution in the middle of described in middle concentrated solution, at 50 DEG C Time relative density be 1.06g/cm³；

4. continuing to concentrate in described middle concentrated solution is placed in jacketed pan, obtain final concentrated solution, described final concentrated solution exists Relative density when 50 DEG C is 1.32g/cm³；

6., by described mixture punch forming drying and shaping, prepare finished medicines brick, wherein, during pressurization in punching course Between be 3min, dry temperature be 42 DEG C, baking duration is 2h.

Experimental example

Enlisting the volunteer of 500 yin-deficiency constitution, be equally divided into 5 groups, group 1-5 uses preparation in embodiment 1-5 respectively Medicine brick coordinates health-preserving heated brick bed to carry out Experiment on therapy, after treating two weeks, tests and assesses the deficiency of YIN situation of its body constitution, and is finally given The evaluation of therapeutic effect, evaluate be divided into, in, differ from three kinds；Wherein, yin-deficiency constitution be improved significantly, deficiency of YIN symptom is the completeest Being chosen as of full disappearance；Yin-deficiency constitution is effectively improved, in being chosen as of deficiency of YIN symptom partial disappearance；Yin-deficiency constitution is substantially without changing Kind, being chosen as of the nearly no disappearance of symptom that the deficiency of YIN causes is poor, obtains the volunteer's demographics result such as following table institute of each evaluation Show.

Group/effect assessment	Good	In	Difference
				1	75	15	10
2	81	12	7
				3	88	10	2
4	92	8	0
				5	95	5	0

As can be seen from the above table, the medicine brick of the present invention, the medicine brick especially prepared according to preferred ingredient proportioning of the present invention, Treatment yin-deficiency constitution aspect effective percentage is high.

Although illustrate and describing the present invention with specific embodiment, but it will be appreciated that without departing substantially from the present invention's May be made that in the case of spirit and scope many other change and amendment.It is, therefore, intended that in the following claims Including all such changes and modifications belonged in the scope of the invention.

Claims

1. the pharmaceutical composition improving yin-deficiency constitution, it is characterised in that described compositions includes below by weight Component:

Fructus Corni 40-80 part, Rhizoma dioscoreae 100-140 part, Radix Rehmanniae Preparata 40-80 part, Rhizoma Alismatis 40-80 part, Radix Rehmanniae Preparata 30-70 part, salt is known Female 10-50 part, stir-baked CORTEX PHELLODENDRI with salt solution 40-80 part, vinegar Carapax Et Plastrum Testudinis 40-80 part, Medulla Sus domestica 10-50 part, Semen Cuscutae 40-80 part, Radix Achyranthis Bidentatae 40-80 Part, Colla Plastri Testudinis 30-70 part, Colla cornus cervi 30-70 part, Fructus Corni 40-80 part, Fructus Lycii 40-80 part, Radix Angelicae Sinensis 60-100 part, the Radix Astragali 100-140 part, Rhizoma Chuanxiong 60-100 part, Radix Paeoniae Rubra 60-100 part, Radix Scrophulariae 40-80 part, 40-80 part Radix Ophiopogonis.

Pharmaceutical composition the most according to claim 1, it is characterised in that described compositions includes below by weight Component:

Fructus Corni 50-70 part, Rhizoma dioscoreae 90-130 part, Radix Rehmanniae Preparata 50-70 part, Rhizoma Alismatis 50-70 part, Radix Rehmanniae Preparata 40-60 part, stir-baked RHIZOMA ANEMARRHENAE before sprinking salt solution 20-40 part, stir-baked CORTEX PHELLODENDRI with salt solution 50-70 part, vinegar Carapax Et Plastrum Testudinis 50-70 part, Medulla Sus domestica 20-40 part, Semen Cuscutae 50-70 part, Radix Achyranthis Bidentatae 50-70 part, Colla Plastri Testudinis 40-60 part, Colla cornus cervi 40-60 part, Fructus Corni 50-70 part, Fructus Lycii 50-70 part, Radix Angelicae Sinensis 70-90 part, Radix Astragali 110-130 Part, Rhizoma Chuanxiong 70-90 part, Radix Paeoniae Rubra 70-90 part, Radix Scrophulariae 50-70 part, 50-70 part Radix Ophiopogonis.

Pharmaceutical composition the most according to claim 1, it is characterised in that described compositions also includes accessory drugs, it is preferable that institute State accessory drugs and include following components by weight:

Herba Artemisiae Annuae 110-130 part, Cortex Lycii 70-90 part, Radix Aucklandiae 140-160 part, Fructus Amomi 50-70 part, Pericarpium Citri Reticulatae 70-90 part, Endothelium Corneum Gigeriae Galli 50-70 part, Semen Ziziphi Spinosae 140-160 part, Radix Polygalae 90-110 part, Cortex Albiziae 50-70 part, Poria 140-160 part, Cortex Moutan 90-110 Part.

4. the medicine brick being used for improving yin-deficiency constitution, it is characterised in that described medicine brick is mainly by any one in claim 1-3 Pharmaceutical composition and loess described in Xiang are made.

Medicine brick the most according to claim 4, it is characterised in that the weight ratio of described loess and described pharmaceutical composition is: (0.5-2):1。

6. the preparation method of the medicine brick described in claim 4 or 5, it is characterised in that said method comprising the steps of:

4) by Fructus Corni, Rhizoma dioscoreae, Radix Rehmanniae Preparata, Rhizoma Alismatis, Radix Rehmanniae Preparata, stir-baked RHIZOMA ANEMARRHENAE before sprinking salt solution, stir-baked CORTEX PHELLODENDRI with salt solution, vinegar Carapax Et Plastrum Testudinis, Medulla Sus domestica, Semen Cuscutae, cattle Knee joint, Colla Plastri Testudinis, Colla cornus cervi, Fructus Corni, Fructus Lycii, Rhizoma Chuanxiong, Radix Paeoniae Rubra, be respectively prepared decoction pieces, after pulverizing and mixing, and with described finally Concentrated solution is mixed to prepare mixture；

Method the most according to claim 6, it is characterised in that the step 4 of described method) in, by Herba Artemisiae Annuae, Cortex Lycii, wood Perfume, Fructus Amomi, Pericarpium Citri Reticulatae, Endothelium Corneum Gigeriae Galli, Semen Ziziphi Spinosae, Radix Polygalae, Cortex Albiziae, Poria, Cortex Moutan are pulverized, with other groups after being also respectively prepared decoction pieces The decoction pieces ground product mixing divided, and together it is mixed to prepare mixture with described final concentrated solution.

Method the most according to claim 6, it is characterised in that described middle concentrated solution, the relative density when 50 DEG C is 1.05-1.08g/cm³；The described final concentrated solution relative density when 50 DEG C is 1.30-1.35g/cm³。

Method the most according to claim 6, it is characterised in that described step 1) in, decoct and carry out twice, add water every time Weight be treat decocting herbs gross weight 8-12 times, each decocting time is 50-70min, and decoct every time after, filtrate crosses 300 mesh Sieve.

Method the most according to claim 6, it is characterised in that described step 5) in, the pressing time in punching course is 2-3min, dries temperature and is 40-45 DEG C, it is preferable that baking duration is 1.5-2.5h.