CN106236936A - A kind of efficient sterilizing containing nanometer carbon crystal dredges intestinal granule and preparation method thereof - Google Patents
A kind of efficient sterilizing containing nanometer carbon crystal dredges intestinal granule and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of efficient sterilizing containing nanometer carbon crystal and dredge intestinal granule, belong to cardiovascular drug the intestines and stomach drug world, be mainly made up of the raw material of following weight parts: nanometer carbon crystal 25 ~ 35 parts, starch slurry 30 ~ 45 parts, Folium Camelliae sinensis powder 20 ~ 30 parts, sucrose 10 ~ 15 parts, glucose 2 ~ 5 parts, aspartame 1 ~ 3 part.The invention also discloses this efficient sterilizing containing nanometer carbon crystal and dredge the preparation method of intestinal granule.It is fabulous that the efficient sterilizing containing nanometer carbon crystal that the present invention provides dredges nanometer carbon crystal biocompatibility in intestinal granule, has no side effect, has good health-care effect after taking to human body.
Description
Technical field
The invention belongs to the intestines and stomach drug world, be specifically related to a kind of efficient sterilizing containing nanometer carbon crystal and dredge intestinal granule and system thereof
Preparation Method.
Background technology
Intestinal is the digestive tube from stomach pylorus to anus, and it is the digestive organs that human body is maximum, is also the toxin expelling of human body maximum
Organ, be maximum immune system at inside of human body, the appearance of its Determines people and beauty.Intestinal include small intestinal, large intestine and
Rectum, the absorption of substantial amounts of Digestion and almost all digestion product is all carried out at little enteral, and large intestine mainly concentrates food
Thing residue, is formed feces, then is excreted by rectum per anum.Under normal circumstances, pathogenic bacteria enters in human body with food, mainly
Approach is through intestinal, and these pathogenic bacterias will be resisted by enteral profitable strain, it is impossible at short notice invade human body other
Circulation, excrete along with defecation soon, nature can not cause ill.But it is as carrying of people's living standard
Height, rhythm of life hectic, lack exercise, live irregular, dietary structure is unreasonable, additive in food and residual agriculture
Medicine, and the impact etc. of psychiatric and social factor destroys normal function and the balance of each organ, harmful toadstool account for
Wind, intestinal movement is hindered, and the wriggling of intestinal and the swing of enteral fine hair weaken, and causes substantial amounts of stool residue to accumulate in large intestine
Fold in, formed stool, because of stool stagnate reason, enteral starts to decay, produce harmful substance, these harmful substances are by intestinal
After absorption, seriously damage the diseases such as health, serious generation cancer.Additionally stool accumulates for a long time at enteral, produces abnormal
Fermentation, the gas of fermentation enters blood, is then transported to pulmonary, discharges together by breathing, cause halitosis from mouth.These
Many diseases have a strong impact on quality of life and the life security of people, and therefore intestinal tract disease increasingly comes into one's own, and becomes in recent years
The emphasis of research.Majority are in order to remove the harmful substance in intestinal at present, it is to avoid long-time internal pathogenic bacteria deteriorates and forms cancer
Etc. serious disease, begin with intestinal lavage and use health promoting beverage carries out the multiple method such as taking good care of and clears up intestinal.
Along with modern life rhythm is accelerated, what a lot of people do and only demand speed and be regardless of the consequences, in health maintenance side
Face shows the most typical, and what all seeks quickness violent, and some people also resorts to every conceivable means: diarrhoea is just just gone with antibiotic, fat-reducing
Liposuction etc., these are all to destroy human body natural's rule, the way of severe damaging body health, lose more than gain the most on the contrary, example
As intestinal constipation occurs with regard to intestinal lavage, intestinal lavage is to be poured water to large intestine by disposable Large Copacity, is beneficial to discharge of defecating, but this is short-term
Behavior, not therapeutical effect, wash once once in a while, it is impossible to solves problem, because metabolite exists everyday；Often intestinal lavage is easy
Cause intestinal microbial population chaotic, cause function of intestinal canal disorderly, cause the symptoms such as abdominal part flatulence, diarrhoea.
It is an incremental process that intestinal is taken good care of, and its metabolism cycle is two weeks, and the whole process of taking good care of should be followed
Intestinal oneself's cycle period, helically formula propradation, make intestinal reach the improvement of a matter.Week is taken good care of in order to follow intestinal
Phase, a lot of doctor scholars and unit utilize the materials such as Folium Camelliae sinensis, Rhizoma amorphophalli, Auricularia and Ganoderma to prepare more eurypalynous health care
Beverage.Such as the beverage made with Folium Camelliae sinensis, after entering gastrointestinal tract because of the tea polyphenols in Folium Camelliae sinensis, can make the nervous function pine of intestinal
Relax, relax intestinal movement, intestinal protein matter can be made again solidify because being made up of protein of antibacterial itself, tea polyphenols and
After bacterioprotein meets, antibacterial is the most dead, serves the effect of protection gastric mucosa, so there being the merit for the treatment of intestinal tract disease
Effect；Catechin component in Folium Camelliae sinensis has the strongest anticancer change activity, can resist human canceration；Vitamin ingredients in Folium Camelliae sinensis
Main component nitrosamine in carcinogen can be made to synthesize, have bigger effect for anti-curing cancers.But based on Folium Camelliae sinensis
It is less with the component that antibacterial is resisted that the health drink wanting composition eventually arrives at intestinal, so antibacterial can not all be killed, stops not
Live the breeding of pathogenic bacteria, take good care of for a long time but without positive effect；Furthermore drinking strong tea in a large number, the tannic acid in Folium Camelliae sinensis is tied mutually with protein
Closing, can generate and have constringent tannalbin matter, make the digestive system of people, drain passage uncomfortable, large and small intestinal peristalsis promoting subtracts
Slowly, run counter to desire, affect health, so having health-care sterilization and anticancer Folium Camelliae sinensis the most not to play its important characteristic.
In recent years, along with the fast development of nanosecond science and technology, nano-particle causes the extensive pass of people with the character of its uniqueness
Note, increasing innovation medical research starts the Nano medication being conceived to nano-particle as carrier, to improving traditional drugs
Many defects of thing.Wherein, the nanoparticle of synthetic receives section as the novel carriers of detection molecules or medicine
Grind the favor of worker, conventional medicament is transform as nanometer novel form and the original new drug with nanoparticle as carrier becomes already
The focus of current nano biological medical domain.At present nano-carrier mainly include Nano diamond, CNT, Nano microsphere,
Nanometer gold and some high molecular polymers etc., wherein Nano diamond is because of the spectrochemical property of its excellence, good biofacies
The features such as capacitive, avirulence and surface can be modified become the emphasis of current research, but the Nano diamond that explosion method produces
The granule reunited by some forms, and pattern is irregular, in-convenience in use, during a large amount of production, particle diameter is relatively decentralized, and granule
Particle diameter is substantially more than 10 nanometers, more than 100 nanometers in the majority, and time medicinal, granule is relatively thick, and effect plays relatively poor.
Summary of the invention
It is an object of the invention to provide a kind of efficient sterilizing containing nanometer carbon crystal and dredge intestinal granule, it is provided that this contains nanometer carbon crystal
Efficient sterilizing to dredge the preparation method of intestinal granule be then another object of the present invention.
Based on above-mentioned purpose, the present invention by the following technical solutions: a kind of efficient sterilizing containing nanometer carbon crystal dredges intestinal granule,
Mainly it is made up of the raw material of following weight parts: nanometer carbon crystal 25 ~ 35 parts, starch slurry 30 ~ 45 parts, Folium Camelliae sinensis powder 20 ~ 30 parts, sucrose 10
~ 15 parts, glucose 2 ~ 5 parts, aspartame 1 ~ 3 part.
Further, described nanometer carbon crystal is class spherical morphology, and C content is 99 ~ 100%, and spacing of lattice is 0.21nm；Should
The dimeric structure of the C atom on nanometer carbon crystal surface and the C atomic building C atom of internal layer diamond phase, the dimer knot of C atom
Two carbon atoms in structure are asymmetric distribution；Mean diameter is R, 0 ＜ R≤20nm, its preparation method reference
CN2015107503345。
Further, in order to activate more avtive spot, make nanometer carbon crystal individual particle molten at follow-up colloid simultaneously
Liquid has good dispersion and does not reunites；Use strong acid oxidizing process that described nanometer carbon crystal is carried out surface-functionalized process, place
Reason process is:
1. nanometer carbon crystal is placed in the dense HNO that mass ratio is 1 (2 ~ 4)3/ dense H2SO4Mixed liquor in, 88～92 DEG C are heated to reflux
Centrifugation after 24h；Taking precipitate be washed with deionized to cleaning mixture pH be 4.0 ~ 5.0；
2. with 0.1 ~ 0.5mol L-1Emulsifying ultrasonic disperse 1 ~ 3h while that NaOH solution washing being sedimentary；
3. with 0.1 ~ 0.5mol L-1Ultrasonic disperse 1 ~ 5h while HCl washing precipitate, is finally washed with deionized after bake
Dry.
Preferably, described starch slurry is formed according to the proportions of 1:1.5 with pure water by starch.
Preferably, the size of described Folium Camelliae sinensis powder is 400 ~ 500 mesh.
The above-mentioned efficient sterilizing containing nanometer carbon crystal dredges the preparation method of intestinal granule, comprises the following steps:
(1) fresh tea leaf is killed enzyme, sterilizing, sorting；Then the leeward at-20 DEG C dissipates dry surface moisture, then dries to moisture ＜
2.5%, it is broken into lamellar tea dust, goes the removal of impurity, reject stalk, then be crushed to 400 ~ 500 mesh and prepare Folium Camelliae sinensis powder；
(2) by nanometer carbon crystal, starch slurry, Folium Camelliae sinensis powder, sucrose, glucose and aspartame mix homogeneously, it is placed in wet granulator
Middle stirring is pelletized for 30 ~ 45 minutes, and dried at 40 ~ 45 DEG C, sieve takes 40 ~ 60 mesh granules；Then radicidation.
Further, the process pulverized in step (1) is: send into after the electronic pulverizing of lamellar tea dust after going the removal of impurity
The bottom of superfinishing Folium Camelliae sinensis powder collecting chamber, collecting chamber bottom is provided with the agitation blades of a diameter of 18 ~ 20 centimetres, and agitation blades is with 3000
The rotating speed of ~ 5000 revolutions per seconds rotates, the tea powder grain in agitation blades agitation collecting chamber so that it is wave, simultaneously at the bottom of collecting chamber
Portion is blown into by cleaner filtered air, and above the distance agitation blades central shaft of collecting chamber top, the position of 2 meters, utilizes and inhale powder
The tea powder waved collected by device, obtains the superfinishing Folium Camelliae sinensis powder of 400 ~ 500 mesh.
Nanometer carbon crystal (being again carbon crystalline substance element) regular appearance used in the present invention, is difficult to reunite, is similar to spherical, scale
During production, particle diameter is the most tiny the most more to be concentrated, and average-size is 2-5 nanometer, and surface activity is that explosion method synthesizes nanometer Buddha's warrior attendant
2-3 times of stone；And the dimer knot of the C atom on nanometer carbon crystal surface a kind of C atom with the C atomic building of diamond phase
Structure, the two carbon atom is asymmetric distribution, the C atom on the Nano diamond surface of explosion method synthesis and the C of diamond phase
Atom also constitutes the dimeric structure of a kind of C atom, and the two C atom is symmetrical, asymmetrical C Atomic Arrangement phase
For the C atom of symmetry arrangement, have more activity, be more prone to be combined from different groups, be more prone to and other
Material is combined with the form of covalent bond or non-covalent bond.The granule that nanometer carbon crystal is prepared together with the material mixing such as Folium Camelliae sinensis
It is not only able to active adsorption pathogenic bacteria, and the materials such as Folium Camelliae sinensis can be carried is directly entered intestinal pathogenic bacteria district, make the one-tenth in Folium Camelliae sinensis have
Effect point plays a role, and plays the effect of efficient sterilizing cleaning intestinal.
It is fabulous that the efficient sterilizing containing nanometer carbon crystal that the present invention provides dredges nanometer carbon crystal biocompatibility in intestinal granule, nontoxic
Side effect, has good health-care effect to human body after taking.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is described in detail.
The nanometer carbon crystal of use of the present invention is class spherical morphology, and C content is 99 ~ 100%, and spacing of lattice is 0.21nm；
The dimeric structure of the C atom on this nanometer carbon crystal surface and the C atomic building C atom of internal layer diamond phase, the dimer of C atom
Two carbon atoms in structure are asymmetric distribution；Mean diameter is R, 0 ＜ R≤20nm, its preparation method reference
CN2015107503345。
Embodiment 1
A kind of efficient sterilizing containing nanometer carbon crystal dredges intestinal granule, is mainly made up of the raw material of following weight parts: nanometer carbon crystal 25 parts,
Starch slurry 45 parts, the Folium Camelliae sinensis powder 30 parts of 400 ~ 500 mesh, sucrose 15 parts, glucose 2 parts, aspartame 1 part；Described starch slurry by
Starch forms according to the proportions of 1:1.5 with pure water.
The above-mentioned efficient sterilizing containing nanometer carbon crystal dredges the preparation method of intestinal granule:
(1) fresh tea leaf is killed enzyme, sterilizing, sorting；Then the leeward at-20 DEG C dissipates dry surface moisture, then dries to moisture ＜
2.5%, it is broken into lamellar tea dust, removes the removal of impurity, rejecting stalk, send after the electronic pulverizing of lamellar tea dust after the removal of impurity being gone
Entering the bottom of superfinishing Folium Camelliae sinensis powder collecting chamber, collecting chamber bottom is provided with the agitation blades of a diameter of 18 ~ 20 centimetres, agitation blades with
The rotating speed of 3000 ~ 5000 revolutions per seconds rotates, the tea powder grain in agitation blades agitation collecting chamber so that it is wave, simultaneously to collection
Being blown into bottom room by cleaner filtered air, above the distance agitation blades central shaft of collecting chamber top, the position of 2 meters, utilizes
Starch absorbing device collects the tea powder waved, and obtains the superfinishing Folium Camelliae sinensis powder of 400 ~ 500 mesh.
(2) by nanometer carbon crystal, starch slurry, Folium Camelliae sinensis powder, sucrose, glucose and aspartame mix homogeneously, it is placed in wet method system
Stirring in grain machine 30 ~ 45 minutes and pelletize, dried at 40 ~ 45 DEG C, sieve takes 40 ~ 60 mesh granules；Then radicidation.
Embodiment 2
A kind of efficient sterilizing containing nanometer carbon crystal dredges intestinal granule, and its material composition is same as in Example 1, and difference is to use
Strong acid oxidizing process carries out surface-functionalized process to nanometer carbon crystal:
1. nanometer carbon crystal is placed in the dense HNO that mass ratio is 123/ dense H2SO4Mixed liquor in, 88～92 DEG C are heated to reflux 24h
Rear centrifugation；Taking precipitate be washed with deionized to cleaning mixture pH be 4.0 ~ 5.0；
2. 0.1mol L is used-1Emulsifying ultrasonic disperse 1 ~ 3h while that NaOH solution washing being sedimentary；
3. 0.1mol L is used-1Ultrasonic disperse 1 ~ 5h while HCl washing precipitate, is finally washed with deionized post-drying.
The above-mentioned efficient sterilizing containing nanometer carbon crystal dredges the preparation method of intestinal granule:
(1) fresh tea leaf is killed enzyme, sterilizing, sorting；Then the leeward at-20 DEG C dissipates dry surface moisture, then dries to moisture ＜
2.5%, it is broken into lamellar tea dust, removes the removal of impurity, rejecting stalk, send after the electronic pulverizing of lamellar tea dust after the removal of impurity being gone
Entering the bottom of superfinishing Folium Camelliae sinensis powder collecting chamber, collecting chamber bottom is provided with the agitation blades of a diameter of 18 ~ 20 centimetres, agitation blades with
The rotating speed of 3000 ~ 5000 revolutions per seconds rotates, the tea powder grain in agitation blades agitation collecting chamber so that it is wave, simultaneously to collection
Being blown into bottom room by cleaner filtered air, above the distance agitation blades central shaft of collecting chamber top, the position of 2 meters, utilizes
Starch absorbing device collects the tea powder waved, and obtains the superfinishing Folium Camelliae sinensis powder of 400 ~ 500 mesh.
(2) use strong acid oxidizing process that described nanometer carbon crystal carries out surface-functionalized process:
1. nanometer carbon crystal is placed in the dense HNO that mass ratio is 123/ dense H2SO4Mixed liquor in, 88～92 DEG C are heated to reflux 24h
Rear centrifugation；Taking precipitate be washed with deionized to cleaning mixture pH be 4.0 ~ 5.0；
2. 0.1mol L is used-1Emulsifying ultrasonic disperse 1 ~ 3h while that NaOH solution washing being sedimentary；
3. 0.1mol L is used-1Ultrasonic disperse 1 ~ 5h while HCl washing precipitate, is finally washed with deionized post-drying.
(3) by nanometer carbon crystal, starch slurry, Folium Camelliae sinensis powder, sucrose, glucose and aspartame mix homogeneously, it is placed in wet method system
Stirring in grain machine 30 ~ 45 minutes and pelletize, dried at 40 ~ 45 DEG C, sieve takes 40 ~ 60 mesh granules；Then radicidation.
Embodiment 3
A kind of efficient sterilizing containing nanometer carbon crystal dredges intestinal granule, is mainly made up of the raw material of following weight parts: nanometer carbon crystal 35 parts,
Starch slurry 30 parts, the Folium Camelliae sinensis powder 20 parts of 400 ~ 500 mesh, sucrose 10 parts, glucose 5 parts, aspartame 3 parts；Described starch slurry by
Starch forms according to the proportions of 1:1.5 with pure water.
(1) fresh tea leaf is killed enzyme, sterilizing, sorting；Then the leeward at-20 DEG C dissipates dry surface moisture, then dries to water
Point ＜ 2.5%, is broken into lamellar tea dust, goes the removal of impurity, rejects stalk, will go the electronic pulverizing of lamellar tea dust after the removal of impurity
The bottom of rear feeding superfinishing Folium Camelliae sinensis powder collecting chamber, collecting chamber bottom is provided with the agitation blades of a diameter of 18 ~ 20 centimetres, agitation blades
Rotate with the rotating speeds of 3000 ~ 5000 revolutions per seconds, the tea powder grain in agitation blades agitation collecting chamber so that it is wave, simultaneously to receipts
It is blown into by cleaner filtered air bottom collection room, the position of 2 meters, profit above the distance agitation blades central shaft of collecting chamber top
Collect the tea powder waved with starch absorbing device, obtain the superfinishing Folium Camelliae sinensis powder of 400 ~ 500 mesh.
(2) use strong acid oxidizing process that described nanometer carbon crystal carries out surface-functionalized process:
1. nanometer carbon crystal is placed in the dense HNO that mass ratio is 143/ dense H2SO4Mixed liquor in, 88～92 DEG C are heated to reflux 24h
Rear centrifugation；Taking precipitate be washed with deionized to cleaning mixture pH be 4.0 ~ 5.0；
2. 0.5mol L is used-1Emulsifying ultrasonic disperse 1 ~ 3h while that NaOH solution washing being sedimentary；
3. 0.5mol L is used-1Ultrasonic disperse 1 ~ 5h while HCl washing precipitate, is finally washed with deionized post-drying.
(3) by nanometer carbon crystal, starch slurry, Folium Camelliae sinensis powder, sucrose, glucose and aspartame mix homogeneously, it is placed in wet method system
Stirring in grain machine 30 ~ 45 minutes and pelletize, dried at 40 ~ 45 DEG C, sieve takes 40 ~ 60 mesh granules；Then radicidation.
Embodiment 4
A kind of efficient sterilizing containing nanometer carbon crystal dredges intestinal granule, is mainly made up of the raw material of following weight parts: nanometer carbon crystal 30 parts,
Starch slurry 35 parts, the Folium Camelliae sinensis powder 25 parts of 400 ~ 500 mesh, sucrose 12 parts, glucose 3 parts, aspartame 2 parts；Described starch slurry by
Starch forms according to the proportions of 1:1.5 with pure water.
(1) fresh tea leaf is killed enzyme, sterilizing, sorting；Then the leeward at-20 DEG C dissipates dry surface moisture, then dries to water
Point ＜ 2.5%, is broken into lamellar tea dust, goes the removal of impurity, rejects stalk, will go the electronic pulverizing of lamellar tea dust after the removal of impurity
The bottom of rear feeding superfinishing Folium Camelliae sinensis powder collecting chamber, collecting chamber bottom is provided with the agitation blades of a diameter of 18 ~ 20 centimetres, agitation blades
Rotate with the rotating speeds of 3000 ~ 5000 revolutions per seconds, the tea powder grain in agitation blades agitation collecting chamber so that it is wave, simultaneously to receipts
It is blown into by cleaner filtered air bottom collection room, the position of 2 meters, profit above the distance agitation blades central shaft of collecting chamber top
Collect the tea powder waved with starch absorbing device, obtain the superfinishing Folium Camelliae sinensis powder of 400 ~ 500 mesh.
(2) use strong acid oxidizing process that described nanometer carbon crystal carries out surface-functionalized process:
1. nanometer carbon crystal is placed in the dense HNO that mass ratio is 133/ dense H2SO4Mixed liquor in, 88～92 DEG C are heated to reflux 24h
Rear centrifugation；Taking precipitate be washed with deionized to cleaning mixture pH be 4.0 ~ 5.0；
2. 0.3mol L is used-1Emulsifying ultrasonic disperse 1 ~ 3h while that NaOH solution washing being sedimentary；
3. 0.3mol L is used-1Ultrasonic disperse 1 ~ 5h while HCl washing precipitate, is finally washed with deionized post-drying.
(3) by nanometer carbon crystal, starch slurry, Folium Camelliae sinensis powder, sucrose, glucose and aspartame mix homogeneously, it is placed in wet method system
Stirring in grain machine 30 ~ 45 minutes and pelletize, dried at 40 ~ 45 DEG C, sieve takes 40 ~ 60 mesh granules；Then radicidation.
Case is tested
Efficient sterilizing is dredged the intestinal granule day for human beings and is recommended consumption to be 6g, is equivalent to 0.0923g/kg ° of bw(adult's body weight in terms of 65kg).
Cleaning grade male mice 12, body weight 20 ~ 23g are selected in experiment.Experimental apparatus is DT1000 electronic balance.During experiment
Mice is randomly divided into 4 groups by body weight, often group 3, is designated as testing 1 group respectively, tests 2 groups, tests 3 groups, tests 4 groups.
Testing 1 group is blank experiment, test 2 groups, test 3 groups and experiment 4 groups respectively per os give embodiment 1 preparation height
Intestinal granule is dredged in effect sterilization, and dosage is respectively 2 times of day for human beings recommended amounts, 5 times and 10 times, corresponds to respectively: 0.1846,
0.4615,0.923g/kg ° of bw.Normal water is taken food, and starts record after giving.Experimental data is: 2 times of consumption group (experiments 2
Group), first grain defecation time average out to 161.4 ± 29.3 min, defecation grain number average out to 32.0 ± 5.7, defecation weight in 8 hours
Amount is 0.86 ± 0.19 g；5 times of consumption groups (testing 3 groups), first grain defecation time average out to 156.3 ± 25.6 min, in 8 hours
Defecation grain number average out to 34.5 ± 6.2, defecation weight is 0.99 ± 0.13g；During 10 times of first grain defecations of consumption group (testing 4 groups)
Between average out to 135.9 ± 20.1min, defecation grain number average out to 42.1 ± 5.4 in 8 hours, defecation weight is 1.27 ±
0.15g；With the first grain average defecation time 162.6 ± 46.2min of mice under normal condition (testing 1 group), averagely arrange in 8 hours
Just several 33.9 ± 12.3 of grain, defecation weight 0.72 ± 0.31g compares, and efficient sterilizing dredges intestinal granule, and can effectively to shorten constipation little
The first grain defecation time of Mus, increases grain number and the weight of institute's defecation.Above-mentioned description of test efficient sterilizing is dredged intestinal granule and can be reached
Substantially clear up the effect of intestinal.
Claims (7)
1. the efficient sterilizing containing nanometer carbon crystal dredges intestinal granule, it is characterised in that be mainly made up of the raw material of following weight parts:
Nanometer carbon crystal 25 ~ 35 parts, starch slurry 30 ~ 45 parts, Folium Camelliae sinensis powder 20 ~ 30 parts, sucrose 10 ~ 15 parts, glucose 2 ~ 5 parts, aspartame 1
~ 3 parts.
Efficient sterilizing containing nanometer carbon crystal the most according to claim 1 dredges intestinal granule, it is characterised in that described nanometer carbon crystal
For class spherical morphology, C content is 99 ~ 100%, and spacing of lattice is 0.21nm；The C atom on this nanometer carbon crystal surface and internal layer Buddha's warrior attendant
The dimeric structure of the C atomic building C atom of stone phase, two carbon atoms in the dimeric structure of C atom are asymmetric distribution；
Mean diameter is R, 0 ＜ R≤20nm.
Efficient sterilizing containing nanometer carbon crystal the most according to claim 2 dredges intestinal granule, it is characterised in that described nanometer carbon crystal
Using strong acid oxidizing process to carry out surface-functionalized process, processing procedure is:
1. nanometer carbon crystal is placed in the dense HNO that mass ratio is 1 (2 ~ 4)3/ dense H2SO4Mixed liquor in, 88～92 DEG C are heated to reflux
Centrifugation after 24h；Taking precipitate be washed with deionized to cleaning mixture pH be 4.0 ~ 5.0；
2. with 0.1 ~ 0.5mol L-1Emulsifying ultrasonic disperse 1 ~ 3h while that NaOH solution washing being sedimentary；
3. with 0.1 ~ 0.5mol L-1Ultrasonic disperse 1 ~ 5h while HCl washing precipitate, is finally washed with deionized after bake
Dry.
Efficient sterilizing containing nanometer carbon crystal the most according to claim 1 dredges intestinal granule, it is characterised in that described starch slurry by
Starch forms according to the proportions of 1:1.5 with pure water.
Efficient sterilizing containing nanometer carbon crystal the most according to claim 1 dredges intestinal granule, it is characterised in that described Folium Camelliae sinensis powder
Size is 400 ~ 500 mesh.
6. the arbitrary described efficient sterilizing containing nanometer carbon crystal of claim 1 ~ 5 dredges the preparation method of intestinal granule, it is characterised in that
Comprise the following steps:
(1) fresh tea leaf is killed enzyme, sterilizing, sorting；Then the leeward at-20 DEG C dissipates dry surface moisture, then dries to moisture ＜
2.5%, it is broken into lamellar tea dust, goes the removal of impurity, reject stalk, then be crushed to 400 ~ 500 mesh and prepare Folium Camelliae sinensis powder；
(2) by nanometer carbon crystal, starch slurry, Folium Camelliae sinensis powder, sucrose, glucose and aspartame mix homogeneously, it is placed in wet granulator
Middle stirring is pelletized for 30 ~ 45 minutes, and dried at 40 ~ 45 DEG C, sieve takes 40 ~ 60 mesh granules；Then radicidation.
Efficient sterilizing containing nanometer carbon crystal the most according to claim 6 dredges the preparation method of intestinal granule, it is characterised in that step
Suddenly the process pulverized in (1) is: send into superfinishing Folium Camelliae sinensis powder collecting chamber after the electronic pulverizing of lamellar tea dust after going the removal of impurity
Bottom, collecting chamber bottom is provided with the agitation blades of a diameter of 18 ~ 20 centimetres, and agitation blades is revolved with the rotating speed of 3000 ~ 5000 revolutions per seconds
Turn, the tea powder grain in agitation blades agitation collecting chamber so that it is wave, be blown into bottom collecting chamber simultaneously and filtered by cleaner
Air, the position of 2 meters above the distance agitation blades central shaft of collecting chamber top, utilize starch absorbing device to collect the tea waved
Powder, obtains the superfinishing Folium Camelliae sinensis powder of 400 ~ 500 mesh.
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| CN201610757331.9A CN106236936A (en) | 2016-08-30 | 2016-08-30 | A kind of efficient sterilizing containing nanometer carbon crystal dredges intestinal granule and preparation method thereof |
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| CN201610757331.9A CN106236936A (en) | 2016-08-30 | 2016-08-30 | A kind of efficient sterilizing containing nanometer carbon crystal dredges intestinal granule and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106883465A (en) * | 2017-04-28 | 2017-06-23 | 郑州人造金刚石及制品工程技术研究中心有限公司 | A kind of preparation method of chitosan composite preservative film |
| CN106893122A (en) * | 2017-02-28 | 2017-06-27 | 河南省豫星华晶微钻有限公司 | PLA base medical thin-film material containing nanometer carbon crystal and preparation method thereof |
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| CN103976090A (en) * | 2014-06-04 | 2014-08-13 | 理想科技集团有限公司 | Tea cream capable of relaxing bowels and aiding digestion and preparation method thereof |
| CN105535989A (en) * | 2015-12-08 | 2016-05-04 | 郑州人造金刚石及制品工程技术研究中心有限公司 | Nano-carbon crystal drug carrier for target identification of tumor cells and preparation method of drug carrier |
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| CN103976090A (en) * | 2014-06-04 | 2014-08-13 | 理想科技集团有限公司 | Tea cream capable of relaxing bowels and aiding digestion and preparation method thereof |
| CN105535989A (en) * | 2015-12-08 | 2016-05-04 | 郑州人造金刚石及制品工程技术研究中心有限公司 | Nano-carbon crystal drug carrier for target identification of tumor cells and preparation method of drug carrier |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106893122A (en) * | 2017-02-28 | 2017-06-27 | 河南省豫星华晶微钻有限公司 | PLA base medical thin-film material containing nanometer carbon crystal and preparation method thereof |
| CN106883465A (en) * | 2017-04-28 | 2017-06-23 | 郑州人造金刚石及制品工程技术研究中心有限公司 | A kind of preparation method of chitosan composite preservative film |
| CN106883465B (en) * | 2017-04-28 | 2020-02-14 | 郑州人造金刚石及制品工程技术研究中心有限公司 | Preparation method of chitosan composite preservative film |
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Address after: 450006 Zhengzhou Economic and Technological Development Zone, Henan Province, west of East Patrol Channel of Zhengzhou Export Processing Zone, Henan Province via Kaidi Ninth Avenue and north of North Fourth Road Applicant after: Henan Yuxing Micro Drilling Co., Ltd. Address before: 450006 Zhengzhou Economic and Technological Development Zone, Henan Province, west of East Patrol Channel of Zhengzhou Export Processing Zone, Henan Province via Kaidi Ninth Avenue and north of North Fourth Road Applicant before: Henan Yuxing Sino Crystal Micron Diamond Co., Ltd. |
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