CN106176598A - 一种盐酸头孢噻呋混悬注射液及其制备方法 - Google Patents
一种盐酸头孢噻呋混悬注射液及其制备方法 Download PDFInfo
- Publication number
- CN106176598A CN106176598A CN201610760425.1A CN201610760425A CN106176598A CN 106176598 A CN106176598 A CN 106176598A CN 201610760425 A CN201610760425 A CN 201610760425A CN 106176598 A CN106176598 A CN 106176598A
- Authority
- CN
- China
- Prior art keywords
- injection
- ceftiofur hydrochloride
- suspension injection
- hydrochloride suspension
- soybean oil
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000002347 injection Methods 0.000 title claims abstract description 40
- 239000007924 injection Substances 0.000 title claims abstract description 40
- KEQFDTJEEQKVLM-JUODUXDSSA-N (6r,7r)-7-[[(2z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-(furan-2-carbonylsulfanylmethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;hydron;chloride Chemical compound Cl.S([C@@H]1[C@@H](C(N1C=1C(O)=O)=O)NC(=O)\C(=N/OC)C=2N=C(N)SC=2)CC=1CSC(=O)C1=CC=CO1 KEQFDTJEEQKVLM-JUODUXDSSA-N 0.000 title claims abstract description 30
- 229960001356 ceftiofur hydrochloride Drugs 0.000 title claims abstract description 30
- 239000000725 suspension Substances 0.000 title claims abstract description 21
- 238000002360 preparation method Methods 0.000 title claims description 8
- 235000012424 soybean oil Nutrition 0.000 claims abstract description 12
- 239000003549 soybean oil Substances 0.000 claims abstract description 12
- 108050004290 Cecropin Proteins 0.000 claims abstract description 11
- CEGOLXSVJUTHNZ-UHFFFAOYSA-K aluminium tristearate Chemical compound [Al+3].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CEGOLXSVJUTHNZ-UHFFFAOYSA-K 0.000 claims abstract description 10
- 238000003756 stirring Methods 0.000 claims description 12
- 238000002156 mixing Methods 0.000 claims description 8
- 238000001816 cooling Methods 0.000 claims description 3
- 239000012467 final product Substances 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 abstract description 6
- 239000006185 dispersion Substances 0.000 abstract description 3
- 230000000857 drug effect Effects 0.000 abstract description 3
- 238000004062 sedimentation Methods 0.000 abstract description 3
- 238000004090 dissolution Methods 0.000 abstract description 2
- 229940079593 drug Drugs 0.000 abstract description 2
- 239000000825 pharmaceutical preparation Substances 0.000 abstract description 2
- 210000004400 mucous membrane Anatomy 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 5
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
- 238000010255 intramuscular injection Methods 0.000 description 3
- 239000007927 intramuscular injection Substances 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- 206010012735 Diarrhoea Diseases 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 208000018569 Respiratory Tract disease Diseases 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 230000001804 emulsifying effect Effects 0.000 description 2
- WCZBUQIZTSIQFE-UHFFFAOYSA-N furan;thiophene Chemical compound C=1C=COC=1.C=1C=CSC=1 WCZBUQIZTSIQFE-UHFFFAOYSA-N 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 230000004083 survival effect Effects 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
- 241000606750 Actinobacillus Species 0.000 description 1
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 1
- 229930186147 Cephalosporin Natural products 0.000 description 1
- 241000606860 Pasteurella Species 0.000 description 1
- 241000607142 Salmonella Species 0.000 description 1
- 241000191940 Staphylococcus Species 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- 241000194017 Streptococcus Species 0.000 description 1
- 229960001138 acetylsalicylic acid Drugs 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 239000004411 aluminium Substances 0.000 description 1
- AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 description 1
- 229960000723 ampicillin Drugs 0.000 description 1
- 230000003064 anti-oxidating effect Effects 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 229960005229 ceftiofur Drugs 0.000 description 1
- ZBHXIWJRIFEVQY-IHMPYVIRSA-N ceftiofur Chemical compound S([C@@H]1[C@@H](C(N1C=1C(O)=O)=O)NC(=O)\C(=N/OC)C=2N=C(N)SC=2)CC=1CSC(=O)C1=CC=CO1 ZBHXIWJRIFEVQY-IHMPYVIRSA-N 0.000 description 1
- 229940124587 cephalosporin Drugs 0.000 description 1
- 150000001780 cephalosporins Chemical class 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- IDYZIJYBMGIQMJ-UHFFFAOYSA-N enoxacin Chemical compound N1=C2N(CC)C=C(C(O)=O)C(=O)C2=CC(F)=C1N1CCNCC1 IDYZIJYBMGIQMJ-UHFFFAOYSA-N 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 239000010985 leather Substances 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 210000004379 membrane Anatomy 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 239000005022 packaging material Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 239000011265 semifinished product Substances 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 239000000273 veterinary drug Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
- A61K31/546—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine containing further heterocyclic rings, e.g. cephalothin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Dermatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Dispersion Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
Claims (2)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610760425.1A CN106176598B (zh) | 2016-08-30 | 2016-08-30 | 一种盐酸头孢噻呋混悬注射液及其制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610760425.1A CN106176598B (zh) | 2016-08-30 | 2016-08-30 | 一种盐酸头孢噻呋混悬注射液及其制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN106176598A true CN106176598A (zh) | 2016-12-07 |
CN106176598B CN106176598B (zh) | 2019-01-08 |
Family
ID=58088895
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201610760425.1A Active CN106176598B (zh) | 2016-08-30 | 2016-08-30 | 一种盐酸头孢噻呋混悬注射液及其制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN106176598B (zh) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111228211A (zh) * | 2020-01-14 | 2020-06-05 | 开封嘉骏生物科技有限公司 | 一种盐酸头孢噻呋注射剂的生产配方及其生产工艺 |
CN114224835A (zh) * | 2021-12-28 | 2022-03-25 | 福建傲农生物制药有限公司 | 一种复方盐酸头孢噻呋注射液及其制备方法和应用 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002066006A1 (en) * | 2001-02-19 | 2002-08-29 | Lg Life Sciences Ltd. | Sustained-release suspension of ceftiofur hydrochloride |
CN101721366A (zh) * | 2010-01-13 | 2010-06-09 | 洛阳惠中兽药有限公司 | 一种β-内酰胺注射液的组成及其制备方法 |
CN102397282A (zh) * | 2010-09-13 | 2012-04-04 | 瑞普(天津)生物药业有限公司 | 一种长效复方头孢噻呋混悬注射剂及其制备方法 |
CN103536529A (zh) * | 2013-10-30 | 2014-01-29 | 游锡火 | 含头孢噻呋长效注射剂及制备方法 |
CN104958313A (zh) * | 2015-06-17 | 2015-10-07 | 侯强红 | 一种替米考星与头孢噻呋注射液及加工设备和工艺 |
-
2016
- 2016-08-30 CN CN201610760425.1A patent/CN106176598B/zh active Active
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002066006A1 (en) * | 2001-02-19 | 2002-08-29 | Lg Life Sciences Ltd. | Sustained-release suspension of ceftiofur hydrochloride |
CN101721366A (zh) * | 2010-01-13 | 2010-06-09 | 洛阳惠中兽药有限公司 | 一种β-内酰胺注射液的组成及其制备方法 |
CN102397282A (zh) * | 2010-09-13 | 2012-04-04 | 瑞普(天津)生物药业有限公司 | 一种长效复方头孢噻呋混悬注射剂及其制备方法 |
CN103536529A (zh) * | 2013-10-30 | 2014-01-29 | 游锡火 | 含头孢噻呋长效注射剂及制备方法 |
CN104958313A (zh) * | 2015-06-17 | 2015-10-07 | 侯强红 | 一种替米考星与头孢噻呋注射液及加工设备和工艺 |
Non-Patent Citations (1)
Title |
---|
陈红伟等: "抗菌肽RSRP与常用抗菌药的体外联合药敏试验", 《中国兽医科学》 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111228211A (zh) * | 2020-01-14 | 2020-06-05 | 开封嘉骏生物科技有限公司 | 一种盐酸头孢噻呋注射剂的生产配方及其生产工艺 |
CN114224835A (zh) * | 2021-12-28 | 2022-03-25 | 福建傲农生物制药有限公司 | 一种复方盐酸头孢噻呋注射液及其制备方法和应用 |
Also Published As
Publication number | Publication date |
---|---|
CN106176598B (zh) | 2019-01-08 |
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GR01 | Patent grant | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
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Denomination of invention: The invention relates to ceftiofur hydrochloride suspension injection and a preparation method thereof Effective date of registration: 20200812 Granted publication date: 20190108 Pledgee: Anyang Investment Group Co.,Ltd. Pledgor: LINZHOU SINAGRI YINGTAI BIOLOGICAL PEPTIDES Co.,Ltd. Registration number: Y2020980004904 |
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Date of cancellation: 20220718 Granted publication date: 20190108 Pledgee: Anyang Investment Group Co.,Ltd. Pledgor: LINZHOU SINAGRI YINGTAI BIOLOGICAL PEPTIDES CO.,LTD. Registration number: Y2020980004904 |
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Denomination of invention: A Cefotaxifur Hydrochloride Suspension Injection and Its Preparation Method Effective date of registration: 20230414 Granted publication date: 20190108 Pledgee: Anyang Investment Group Co.,Ltd. Pledgor: LINZHOU SINAGRI YINGTAI BIOLOGICAL PEPTIDES CO.,LTD. Registration number: Y2023980038083 |