CN106172431A - A kind of Fluxapyroxad-containsterilization and the bactericidal composition of probenazole - Google Patents
A kind of Fluxapyroxad-containsterilization and the bactericidal composition of probenazole Download PDFInfo
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- CN106172431A CN106172431A CN201610547375.9A CN201610547375A CN106172431A CN 106172431 A CN106172431 A CN 106172431A CN 201610547375 A CN201610547375 A CN 201610547375A CN 106172431 A CN106172431 A CN 106172431A
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- probenazole
- fluxapyroxad
- bactericidal composition
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/74—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,3
- A01N43/78—1,3-Thiazoles; Hydrogenated 1,3-thiazoles
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/56—1,2-Diazoles; Hydrogenated 1,2-diazoles
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- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
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- General Health & Medical Sciences (AREA)
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Abstract
The invention discloses the bactericidal composition of a kind of Fluxapyroxad-containsterilization and probenazole, the active component of described microbicide compositions is fluxapyroxad and probenazole, probenazole is 1:20 to 20:1 with the mass ratio of fluxapyroxad, and in compositions, active component weight/mass percentage composition is 5 60%.It is high that the microbicide compositions of the present invention has bactericidal activity, delays the drug-fast generation of pathogen and development simultaneously, and minimizing produces in reality and prevents and treats dosage, economical, efficient, safe and environment-friendly, especially pronounced to rice sheath blight disease controlling effect.
Description
Technical field
The present invention relates to disinfectant use in agriculture field, a kind of Fluxapyroxad-containsterilization and the bactericidal composition of probenazole,
For preventing and treating rice sheath blight disease.
Background technology
Rice sheath blight disease is by the popular disease in the microbial worldwide scope of miliary damping-off, on Ye Shi China Oryza sativa L.
One of most important disease.Its distribution widely, has generation in China each Oryza sativa L. main producing region, especially on ground, the middle and lower reach of Yangtze River
District and South China, harm is very serious, causes yield drastically to decline.Selection-breeding and popularization disease-resistant variety, be preventing and treating rice banded sclerotial blight
One of sick important measures, in recent years, although Chinese scholars achieves a lot of progress in terms of breeding for disease resistance, but there is no at present
Select the rice varieties of immunity complete to rice sheath blight disease.Rhizoctonia solani Kuhn preventing and treating at present is also to rely on chemical control.
China is preventing and treating the medicament having been used up in rice sheath blight disease based on jingganmycin, the most i.e. at rice tillering at present
Diseased plant rate reached about 15% and started to spray medicine preventing and treating latter stage, and achieved certain effect.But have been reported display, China's part
Area rice sheath blight disease has created Drug resistance to jingganmycin, and the prevention effect of this medicament caused constantly declines.If
Continue to control rice sheath blight disease, especially filter out the surrogate-data technique preventing and treating rice sheath blight disease, administer jingganmycin drug resistance simultaneously
Property and promote the sustainable control of rice sheath blight disease, it has also become what numerous scientific workers and Rice Cropping person faced great chooses
War.
Probenazole is a kind of efficient, wide spectrum, systemic fungicide, can prevent and treat orange storing disease, Fructus Musae disease, Semen Tritici aestivi
The plurality of plant diseases such as head blight, bakanae disease of rice, the penicilliosis of apple core pears, anthrax, gray mold, scab, powdery mildew,
Control of plant disease is had concurrently protective effect and therapeutical effect.
Fluxapyroxad (fluxapyroxad), chemical name: 3-(difluoro)-1-methyl-N-(3', 4', 5'-trifluoro [1,
1'-biphenyl]-2-base)-1-H-pyrazoles-4-amide, fluxapyroxad belongs to pyrazole amide series bactericidal agent, and succinate dehydrogenase suppresses
Agent, preventing and treating is had both.It can suppress the Repiration of fungus, suppresses spore-germination, and germ tube extends, mycelial growth and spore shape
Become.Can be used for the multiple fungal disease controlling and suppressing in various crop.By superior lasting effect and lasting transmission characteristic
It is integrated in one.
Fluxapyroxad molecular formula C18H12F5N3O, structural formula is:
Probenazole and fluxapyroxad single dose life-time service, easily make disease develop immunity to drugs, and causes dosage to strengthen, prevents
The problem that effect reduces, the lasting period shortens, is unfavorable for environment sustainable development.And the effective ingredient of the difference mechanism of action carries out multiple
Join, be to delay disease to develop immunity to drugs conventional method, and according to the effect in production application, judge this compounding be to increase
Effect effect or antagonism.The obvious formula of complex role, can significantly improve preventive effect, is substantially reduced the medication of pesticide
Amount, also can expand fungicidal spectrum, improves germicidal efficiency.
Summary of the invention
The invention provides the bactericidal composition of a kind of Fluxapyroxad-containsterilization and probenazole, there is bactericidal activity high, delay
Pathogen Drug resistance produces and development, and makes dosage total in unit are decline, economic, efficient, environmental protection, in preventing and treating Oryza sativa L.
Specially good effect is had in banded sclerotial blight.
The antibacterial that two classes are had different mechanism of action by the present invention is combined, and is processed into the upper easy-to-use system of production
Agent, is used alone in two kinds of compositions and compares, and has biological activity high, and dosage total in unit are declines, and is substantially reduced
Dispenser cost, delays pathogen Drug resistance to produce to a greater extent and development simultaneously, reduces pathogenic fungi and kill single
Microbial inoculum produces the risk of resistance, extends the service life of each component in bactericidal composition, thus realizes economy, efficient, environmental protection
Goal of the invention.
The technical scheme is that
A kind of Fluxapyroxad-containsterilization and the microbicide compositions of probenazole, it is characterised in that described microbicide compositions
Active component be the mass ratio of fluxapyroxad and probenazole, fluxapyroxad and probenazole be 1:20 to 20:1, in compositions
Active component weight/mass percentage composition is 5-60%.
Described Fluxapyroxad-containsterilization and the bactericidal composition of probenazole, it is characterised in that: described active component fluorine azoles
The mass ratio of bacterium amide and probenazole is 1:10 to 10:1.
Described Fluxapyroxad-containsterilization and the bactericidal composition of probenazole, it is characterised in that: described fluxapyroxad and
The mass ratio of probenazole is 1:3-8.
Described Fluxapyroxad-containsterilization and the bactericidal composition of probenazole, it is characterised in that: described fluxapyroxad and
The mass ratio of probenazole is 1:4-6.
Described Fluxapyroxad-containsterilization and the microbicide compositions of probenazole, it is characterised in that: described microbicide compositions
Dosage form be wettable powder, water dispersible granules, suspending agent or cream.
The microbicide compositions application of described Fluxapyroxad-containsterilization and probenazole, it is characterised in that: this antimicrobial combination
Thing is especially pronounced to the prevention effect of rice sheath blight disease.
Remarkable result and the advantage of the present invention be:
The present invention has the highest prevention effect to rice sheath blight disease, there is notable synergistic effect between two components；Can replace
Part high price pesticide species, and reduce dosage, effectively reduces ecological disruption and environmental pollution, and can improve wheat yield and
Quality；In the present invention, fluxapyroxad and probenazole all belong to the toxicity such as low, and to people and animals, beneficial organism, Environmental security；Can prolong
The slow pathogenic bacteria Drug resistance to single medicament.
First fluxapyroxad and the EC of probenazole two single compound (hereinafter referred to as medicament) are measured50(drug safety
Index), according to the EC of two single medicaments50The portfolio ratio of two medicaments is set by Wadley method, and according to Wadley coefficient of synergism C
Value, determines suitable compositions ratio, is then verified by the abundant method of Sun Yun.
Test objective thing is Rhizoctonia solani Kuhn, but does not limit so.Test uses mycelial growth algoscopy, by different disposal
Make pastille culture medium, 4 repetitions of each process, after connecing bacterium 3 days, investigate each process and the growth inhibited of Rhizoctonia solani Kuhn is imitated
Really.By the linear regression analysis between probit value and the logarithm value of series drug concentration of preventive effect, obtain the EC of each medicament50,
Calculate coefficient of synergism (SR) according to Wadley method, and make overall merit accordingly.SR≤0.5 represents have antagonism, 0.5 ＜
SR ＜ 1.5 represents have summation action, and SR >=1.5 are potentiation.SR value calculating method is as follows:
EC50(theoretical value)=(a+b)/(a/EC50A+b/EC50B)
SR=EC50(theoretical value)/EC50(actual value)
SR≤0.5, then two kinds of medicament mixtures have antagonistic action
SR=0.5～1.5, then two kinds of medicament mixtures have addition
SR >=1.5, then two kinds of medicament mixtures have potentiation
Table 1 fluxapyroxad and the probenazole compositions Wadley method measurement result to rice sheath blight disease
Note: S is probenazole, and F is fluxapyroxad.
Can analyze from data above, the fluxapyroxad of different proportion and probenazole compositions are to Rhizoctonia solani Kuhn
Fungistatic effect is different, and on the whole, its ratio has potentiation or addition in the range of 1:20 to 20:1,
Big enhancing proportions is 5:1.
Below in conjunction with embodiment, the invention will be further described, but is not limited to this.
Detailed description of the invention
Embodiment 1 (preparation method of 60% fluxapyroxad probenazole wettable powder)
Composition of raw materials: by mass percentage
Preparation method is as follows:
Uniformly being mixed by above-mentioned substance, mixture is pulverized through jet mill, prepares wettable powder.
Embodiment 2 (preparation method of 30% fluxapyroxad probenazole suspending agent)
Preparation method: according to formula, individual component weighed in proportion, adds ball mill ball milling 30 minutes, filters, and suction divides
Dissipating tank high speed shear to be fully ground through sand mill after 3 minutes, control solid constituent particle diameter is within 2 microns, and grinding terminates
After stir, obtain suspending agent product.
Embodiment 3 (preparation method of 40% fluxapyroxad probenazole water dispersible granules)
Preparation method: by fluxapyroxad, probenazole, Methyl fatty amide benzene sulfonic acid sodium salt, sodium carbonate, attapulgite together
After mix homogeneously, it is crushed to particle diameter 5 μm through jet mill, obtains female powder, make after mother's powder is sufficiently mixed with sodium lignin sulfonate
Grain, dry, sieve, thus prepare water-dispersible granules.
Embodiment 4 (preparation method of 20% fluxapyroxad probenazole suspending agent)
Preparation method: with embodiment 2.
Embodiment 5 (preparation method of 45% fluxapyroxad probenazole cream)
Composition of raw materials: by mass percentage
Preparation method: active component fluxapyroxad fully dissolved in dimethylbenzene reactor, makes A liquid；By activity
Component probenazole fully dissolves in dimethylbenzene reactor, makes B liquid；Under not stopping stirring, A liquid is mixed into B liquid, fully
Stir, add anhydrous calcium salt and NP-10, then adjust content with solvent xylene.
Embodiment 6 (preparation method of 48% fluxapyroxad probenazole cream)
Composition of raw materials: by mass percentage
Preparation method: with embodiment 5.
Prevention effect is tested:
The field efficiency test of rice sheath blight disease is carried out in suburb, Bengbu, and test area is 0.3hm2, often process repetition
Three times, carrying out latter stage spraying medicine preventing and treating at rice tillering, carry out preventive effect investigation in dispenser after 15 days, preventing and treating the results are shown in Table 2.Result table
Bright, the bactericidal composition containing fluxapyroxad and probenazole has good prevention effect to rice sheath blight disease, at identical dose
Higher prevention effect can be reached under amount or relatively low using dosage, and each process preventive effect bacterium of this bactericidal composition is more than 85%,
It is significantly higher than comparison medicament.
Table 2 probenazole fluxapyroxad bactericidal composition prevents and treats land for growing field crops drug effect * of rice sheath blight disease
It should be noted that when the proportioning of fluxapyroxad and probenazole is 5:1, compared with other process, relatively low
Consumption under there is higher preventive effect, it is shown that preferably synergistic function；And indoor biometrics result also indicates that, fluorine azoles bacterium acyl
When the proportioning of amine and probenazole is 5:1, the coefficient of synergism measured is the highest, and the result of the two is consistent.
Finally, in addition it is also necessary to be only several specific embodiments of the present invention it is noted that listed above.Obviously, this
Bright it is not limited to above embodiment, it is also possible to have many variations.Those of ordinary skill in the art can be in disclosed by the invention
Hold all deformation directly derived or associate, be all considered the scope of protection of the invention.
Claims (6)
1. a Fluxapyroxad-containsterilization and the bactericidal composition of probenazole, it is characterised in that active group of described bactericidal composition
The mass ratio being divided into fluxapyroxad and probenazole, fluxapyroxad and probenazole is 1:20 to 20:1, activity group in compositions
Dividing weight/mass percentage composition is 5-60%.
Fluxapyroxad-containsterilization the most according to claim 1 and the bactericidal composition of probenazole, it is characterised in that: described work
The mass ratio of property component fluxapyroxad and probenazole is 1:10 to 10:1.
Fluxapyroxad-containsterilization the most according to claim 1 and the bactericidal composition of probenazole, it is characterised in that: described fluorine
The mass ratio of azoles bacterium amide and probenazole is 1:3-8.
Fluxapyroxad-containsterilization the most according to claim 1 and the bactericidal composition of probenazole, it is characterised in that: described fluorine
The mass ratio of azoles bacterium amide and probenazole is 1:4-6.
Fluxapyroxad-containsterilization the most according to claim 1 and 2 and the bactericidal composition of probenazole, it is characterised in that: described
The dosage form of bactericidal composition is wettable powder, water dispersible granules, suspending agent or cream.
The bactericidal composition application of Fluxapyroxad-containsterilization the most according to claim 1 and 2 and probenazole, it is characterised in that:
Described bactericidal composition has the highest prevention effect to rice banded sclerotial blight disease.
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| CN201610547375.9A CN106172431A (en) | 2016-07-12 | 2016-07-12 | A kind of Fluxapyroxad-containsterilization and the bactericidal composition of probenazole |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101257798A (en) * | 2005-08-05 | 2008-09-03 | 巴斯福股份公司 | Fungicidal mixtures containing substituted 1-methyl pyrazol-4-yl carboxylic acid anilides |
| CN103385250A (en) * | 2012-05-09 | 2013-11-13 | 陕西韦尔奇作物保护有限公司 | Bactericidal composition containing fluxapyroxad |
| CN105831131A (en) * | 2016-04-26 | 2016-08-10 | 南京华洲药业有限公司 | Bactericidal composition containing fluxapyroxad and thiabendazole and application thereof |
-
2016
- 2016-07-12 CN CN201610547375.9A patent/CN106172431A/en not_active Withdrawn
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101257798A (en) * | 2005-08-05 | 2008-09-03 | 巴斯福股份公司 | Fungicidal mixtures containing substituted 1-methyl pyrazol-4-yl carboxylic acid anilides |
| CN103385250A (en) * | 2012-05-09 | 2013-11-13 | 陕西韦尔奇作物保护有限公司 | Bactericidal composition containing fluxapyroxad |
| CN105831131A (en) * | 2016-04-26 | 2016-08-10 | 南京华洲药业有限公司 | Bactericidal composition containing fluxapyroxad and thiabendazole and application thereof |
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