CN106153663B - A kind of biological medicine high sensitivity nuclear magnetic resonance equipment - Google Patents
A kind of biological medicine high sensitivity nuclear magnetic resonance equipment Download PDFInfo
- Publication number
- CN106153663B CN106153663B CN201610445178.6A CN201610445178A CN106153663B CN 106153663 B CN106153663 B CN 106153663B CN 201610445178 A CN201610445178 A CN 201610445178A CN 106153663 B CN106153663 B CN 106153663B
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- frequency
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N24/00—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
- G01N24/08—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using nuclear magnetic resonance
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- High Energy & Nuclear Physics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
Abstract
The present invention discloses a kind of pharmaceutical nuclear magnetic resonance equipment of sensitivity, including：Frequency meter, for producing RF pulse signal；Radio-frequency oscillator, corresponding pulse current is produced according to the RF pulse signal from the frequency meter, and receive the sample feedback signal from radio-frequency coil；Radio-frequency coil, including even number rectangle subcoil, first transmission line for being located at axle center is formed after the side long side extension of this rectangle subcoil, extension forms the second transmission line after the short side bending adjacent with this long side, several rectangle subcoils are in parallel and arranged at equal intervals form the radio-frequency coil, connected after several the second transmission line other end bendings through a closed loop coil.The present invention has higher quality factor, and the radio-frequency power that can be carried is 30kHz, and the uniformity of RF magnetic field is 4.6%.High-power exciting and good RF magnetic field distribution are realized, substantially increases the accuracy and sensitivity of measurement.
Description
Technical field
The present invention relates to NMR analysis devices field, and in particular to a kind of pharmaceutical nuclear magnetic resonance equipment of sensitivity.
Background technology
In view of nuclear magnetic resonance technique is extensive in the basic research such as chemistry, biology and clinical medicine, drug development
Using various high resolution NMR analytical technologies turn into the important tool in Biochemical Research.Go for the nuclear-magnetism of high quality
The parameter such as spectrogram, the alternating temperature performance of nuclear magnetic resonance rotor adapter, rotational stabilization that resonates seems extremely important.Especially it is intended to
High-resolution nmr spectrum is obtained, it is necessary to using the larger rotor adapter of extent of alternating temperature（- 200 to 200 DEG C）With make sample
Product rotate（More than 20 rpm）, now need to ensure the stability of sample tube when rotated.Rotor adapter common at present,
The relevant parameters such as the magnetic susceptibility and Mass Distribution of its material are unsatisfactory for the demand used in large temperature range, and in height
Under rotating speed, the less stable of rotor adapter so that the process for carrying out high resolution NMR experiment becomes extremely complex.
On the other hand, it is desirable to obtain the nmr spectrum of high quality, load power, the radio frequency of NMR RF coil
The parameters such as magnetic field's regularity seem extremely important.Especially go for high-resolution nmr spectrum, it is often necessary to make
With the higher radio-frequency coil of load power（More than 20kHz）, geometry and space structure at this point for radio-frequency coil just carry
Higher requirement is gone out.Common radio-frequency coil at present, such as solenoid type radio-frequency coil, and Hai Muhuozi type radio-frequency coils,
The maximum intensity of its radiofrequency field that can apply is 10 ~ 15kHz, is unsatisfactory for applying the demand of the radiofrequency field of more power so that
Carrying out high resolution NMR experiment becomes to be difficult to.
The content of the invention
The present invention provides a kind of pharmaceutical nuclear magnetic resonance equipment of sensitivity, and the pharmaceutical nuclear magnetic resonance equipment of this sensitivity has
Higher quality factor, the radio-frequency power that can be carried are 30kHz, and the uniformity of RF magnetic field is 4.6%.High power is realized to swash
Hair and good RF magnetic field are distributed, and substantially increase the accuracy and sensitivity of measurement.
To reach above-mentioned purpose, the technical solution adopted by the present invention is：A kind of pharmaceutical nuclear magnetic resonance equipment of sensitivity, bag
Include：
Frequency meter, for producing RF pulse signal；
Radio-frequency oscillator, corresponding pulse current is produced according to the RF pulse signal from the frequency meter, and connect
Receive the sample feedback signal from radio-frequency coil；
Radio-frequency coil, according to the pulse current product alternating electromagnetic field from the radio-frequency oscillator, and sense generation table
The sample feedback signal of sample nuclear spin energy level is levied, the radio-frequency coil includes even number rectangle subcoil, this rectangle subcoil
The extension of side long side after form first transmission line for being located at axle center, after the short side bending adjacent with this long side extension form the
Two transmission lines, several rectangle subcoils are in parallel and arranged at equal intervals form the radio-frequency coil；
Modulator receiver, the radio-frequency oscillator is connected to, for extracting the sample feedback signal from radio-frequency oscillator;
Sample cell for carrying detected sample is located on the radio-frequency coil axial line and immediately below it, this sample
QC is installed on a rotor fixture；
First magnet and the second magnet are located at the sample cell both sides respectively, quiet for being provided to the sample in this sample cell
Magnetic field；
Connected after several described the second transmission line other end bendings through a closed loop coil.
Further improvement project in above-mentioned technical proposal is as follows：
1. in such scheme, the rectangle subcoil number is 6, and adjacent rectangle subcoil is at intervals of 60 degree.
2. in such scheme, the scapus, upper fastener, lower fastener and cap body material are polytetrafluoroethylene (PTFE).
Because above-mentioned technical proposal is used, the present invention has following advantages and effect compared with prior art：
1. the pharmaceutical nuclear magnetic resonance equipment of sensitivity of the present invention, it is applied to the transmitting and reception of pulse signal, can be used for
The research of high resolution NMR experiment；The apparatus structure is close, has higher quality factor, and the radio-frequency power that can be carried is
30kHz, the uniformity of RF magnetic field is 4.6%.High-power exciting and good RF magnetic field distribution are realized, is substantially increased
The accuracy and sensitivity of measurement.
2. employing six groups of wires in the pharmaceutical nuclear magnetic resonance equipment of sensitivity of the present invention, formed with one group of wire of tradition
Solenoid type coil compared with the Helmholtz coil being made up of two groups of wires, structure is finer, can realize more complicated
Radiofrequency field.
3. the coil device of the present invention realizes high power, there is six subcoils, total radio frequency work(in a coil
Rate is distributed to six subcoils.In the case where each subcoil peak power is constant, general power is improved, therefore improve into
The resolution ratio of picture.
4. the coil device of the present invention improves the uniformity of RF magnetic field, six subcoils are employed, using its each
RF magnetic field mutually compensated at space overlap, improve the spatial uniformity in single coil magnetic field, improve single line
The Distribution of Magnetic Field of circle.
5. the coil device of the present invention is easy for installation, can be used directly to replace original coil, without changing other
Hardware, compared with traditional coil, the coil has very big change in shape, the change based on shape, with reference to above-mentioned
Illustrate, the coil has the characteristics of following：（1）Improve the radio-frequency power of coil；（2）Improve the uniformity of magnetic field of coil；
（3）It is easy to install and use.
Brief description of the drawings
Accompanying drawing 1 is the pharmaceutical nuclear magnetic resonance equipment principle schematic of sensitivity of the present invention；
Accompanying drawing 2 is rectangle subcoil structural representation in radio-frequency coil of the present invention；
Accompanying drawing 3 is radio-frequency coil partial schematic diagram of the present invention；
Accompanying drawing 4 is radio-frequency coil structure schematic diagram of the present invention.
In the figures above：1st, frequency meter；2nd, radio-frequency oscillator；3rd, radio-frequency coil；4th, modulator receiver；5th, sample cell；6、
Rotor fixture；7th, rectangle subcoil；8th, long side；9th, the first transmission line；10th, short side；11st, the second transmission line；12nd, the first magnetic
Body；13rd, the second magnet；14th, closed loop coil.
Embodiment
Below in conjunction with the accompanying drawings and embodiment the invention will be further described：
Embodiment：A kind of pharmaceutical nuclear magnetic resonance equipment of sensitivity, as shown in accompanying drawing 1 ~ 4, including：
Frequency meter 1, for producing RF pulse signal；
Radio-frequency oscillator 2, corresponding pulse current is produced according to the RF pulse signal from the frequency meter, and connect
Receive the sample feedback signal from radio-frequency coil；
Radio-frequency coil 3, according to the pulse current product alternating electromagnetic field from the radio-frequency oscillator 2, and sense generation
The sample feedback signal of sample nuclear spin energy level is characterized, the radio-frequency coil 3 includes even number rectangle subcoil 7, this rectangle
The side long side 8 of coil 7 forms first transmission line 9 for being located at axle center after extending, after the bending of short side 10 adjacent with this long side 8
Extension forms the second transmission line 11, and several rectangle subcoils 7 are in parallel and arranged at equal intervals form the radio-frequency coil 3；
Modulator receiver 4, the radio-frequency oscillator 2 is connected to, for extracting the sample feedback letter from radio-frequency oscillator 2
Number;
Sample cell 5 for carrying detected sample is located on the axial line of radio-frequency coil 3 and immediately below it, this
Sample cell is installed on a rotor fixture 6；
First magnet 12 and the second magnet 13 are located at the both sides of sample cell 5 respectively, for the sample in this sample cell 5
Magnetostatic field is provided.
Connected after several above-mentioned other end bendings of the second transmission line 11 through a closed loop coil 14；The above-mentioned rectangle sub-line number of turns
Mesh is 6, and adjacent rectangle subcoil is at intervals of 60 degree.
During nuclear magnetic resonance equipment pharmaceutical using above-mentioned sensitivity, it is applied to the transmitting and reception of pulse signal, can use
In the research of high resolution NMR experiment；The apparatus structure is close, has higher quality factor, the radio-frequency power that can be carried
For 30kHz, the uniformity of RF magnetic field is 4.6%.High-power exciting and good RF magnetic field distribution are realized, is greatly improved
The accuracy and sensitivity of measurement；Secondly, six groups of wires are employed in nuclear magnetic resonance device, the spiral shell formed with one group of wire of tradition
Spool type coil is compared with the Helmholtz coil being made up of two groups of wires, and structure is finer, can realize more complicated penetrate
Frequency field；Again, coil device realizes high power.There are six subcoils in a coil, total radio-frequency power is distributed to
Six subcoils.In the case where each subcoil peak power is constant, general power is improved, therefore improves the resolution of imaging
Rate；Again, nuclear magnetic resonance device improves the uniformity of RF magnetic field, employs six subcoils, utilizes its respective radio frequency
Magnetic field mutually compensates at space overlap, improves the spatial uniformity in single coil magnetic field, improves the magnetic of single coil
Field distribution.
The above embodiments merely illustrate the technical concept and features of the present invention, and its object is to allow person skilled in the art
Scholar can understand present disclosure and implement according to this, and it is not intended to limit the scope of the present invention.It is all according to the present invention
The equivalent change or modification that Spirit Essence is made, it should all be included within the scope of the present invention.
Claims (1)
- A kind of 1. biological medicine high sensitivity nuclear magnetic resonance equipment, it is characterised in that：Including：Frequency meter（1）, for producing RF pulse signal；Radio-frequency oscillator（2）, corresponding pulse current is produced according to the RF pulse signal from the frequency meter, and receive Sample feedback signal from radio-frequency coil；Radio-frequency coil（3）, according to from the radio-frequency oscillator（2）Pulse current produce alternating electromagnetic field, and sense generation Characterize the sample feedback signal of sample nuclear spin energy level, the radio-frequency coil（3）Including even number rectangle subcoil（7）, this square Shape subcoil（7）Side long side（8）First transmission line for being located at axle center is formed after extension（9）, it is same with this first transmission line The short side of side（10）Extension forms the second transmission line after bending（11）, several rectangle subcoils（7）In parallel and arranged at equal intervals Form the radio-frequency coil（3）；Modulator receiver（4）, it is connected to the radio-frequency oscillator（2）, radio-frequency oscillator is come from for extracting（2）Sample feedback Signal；For carrying the sample cell of detected sample（5）Positioned at the radio-frequency coil（3）On axial line and immediately below it, this Sample cell is installed on a rotor fixture（6）On；First magnet（12）With the second magnet（13）It is located at the sample cell respectively（5）Both sides, for giving this sample cell（5）Interior Sample provides magnetostatic field；Several described second transmission lines（11）Through a closed loop coil after other end bending（14）Connection；The rectangle subcoil （7）Number is 6, adjacent rectangle subcoil（7）At intervals of 60 degree；The rotor fixture（6）Material is polytetrafluoroethylene (PTFE).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610445178.6A CN106153663B (en) | 2013-03-05 | 2013-03-05 | A kind of biological medicine high sensitivity nuclear magnetic resonance equipment |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310068814.4A CN103207199B (en) | 2013-03-05 | 2013-03-05 | For the nuclear magnetic resonance device of biological medicine |
| CN201610445178.6A CN106153663B (en) | 2013-03-05 | 2013-03-05 | A kind of biological medicine high sensitivity nuclear magnetic resonance equipment |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310068814.4A Division CN103207199B (en) | 2013-03-05 | 2013-03-05 | For the nuclear magnetic resonance device of biological medicine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN106153663A CN106153663A (en) | 2016-11-23 |
| CN106153663B true CN106153663B (en) | 2018-04-10 |
Family
ID=48754486
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310068814.4A Expired - Fee Related CN103207199B (en) | 2013-03-05 | 2013-03-05 | For the nuclear magnetic resonance device of biological medicine |
| CN201610445226.1A Expired - Fee Related CN106168589B (en) | 2013-03-05 | 2013-03-05 | A kind of biological medicine high resolution nuclear magnetic resonance analyzer |
| CN201610445178.6A Expired - Fee Related CN106153663B (en) | 2013-03-05 | 2013-03-05 | A kind of biological medicine high sensitivity nuclear magnetic resonance equipment |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310068814.4A Expired - Fee Related CN103207199B (en) | 2013-03-05 | 2013-03-05 | For the nuclear magnetic resonance device of biological medicine |
| CN201610445226.1A Expired - Fee Related CN106168589B (en) | 2013-03-05 | 2013-03-05 | A kind of biological medicine high resolution nuclear magnetic resonance analyzer |
Country Status (1)
| Country | Link |
|---|---|
| CN (3) | CN103207199B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106483159B (en) * | 2016-11-23 | 2018-11-13 | 青海七彩花生物科技有限公司 | A kind of biological medicine scintilla NMR analysis devices and its analysis method |
| CN108505986A (en) * | 2018-03-09 | 2018-09-07 | 中国石油天然气股份有限公司 | Nuclear magnetic resonance downhole fluid identification device and its downhole fluid identification probe |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS55154449A (en) * | 1979-05-21 | 1980-12-02 | Hitachi Ltd | Nuclear magnetic resonance apparatus |
| US4275350A (en) * | 1979-05-29 | 1981-06-23 | Varian Associates, Inc. | Sample spinning mechanism for NMR probes |
| CN100416294C (en) * | 2002-06-21 | 2008-09-03 | 皇家飞利浦电子股份有限公司 | Magnetic resonance imaging apparatus and method |
| CN202712411U (en) * | 2011-11-14 | 2013-01-30 | 西安电子科技大学 | Wideband dual-polarization base station antenna radiation unit |
| CN203224464U (en) * | 2013-03-05 | 2013-10-02 | 杨晓冬 | Nuclear-magnetic-resonance device for biological medicines |
-
2013
- 2013-03-05 CN CN201310068814.4A patent/CN103207199B/en not_active Expired - Fee Related
- 2013-03-05 CN CN201610445226.1A patent/CN106168589B/en not_active Expired - Fee Related
- 2013-03-05 CN CN201610445178.6A patent/CN106153663B/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN106168589B (en) | 2018-08-17 |
| CN106168589A (en) | 2016-11-30 |
| CN103207199A (en) | 2013-07-17 |
| CN103207199B (en) | 2016-05-18 |
| CN106153663A (en) | 2016-11-23 |
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Granted publication date: 20180410 Termination date: 20190305 |