CN106153663A - The pharmaceutical nuclear magnetic resonance equipment of sensitivity - Google Patents
The pharmaceutical nuclear magnetic resonance equipment of sensitivity Download PDFInfo
- Publication number
- CN106153663A CN106153663A CN201610445178.6A CN201610445178A CN106153663A CN 106153663 A CN106153663 A CN 106153663A CN 201610445178 A CN201610445178 A CN 201610445178A CN 106153663 A CN106153663 A CN 106153663A
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- radio
- frequency
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- sample
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N24/00—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
- G01N24/08—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using nuclear magnetic resonance
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- High Energy & Nuclear Physics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
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- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
Abstract
The open a kind of pharmaceutical nuclear magnetic resonance equipment of sensitivity of the present invention, including: cymometer, it is used for producing RF pulse signal；Radio-frequency oscillator, produces corresponding pulse current according to the RF pulse signal from described cymometer, and receives the sample feedback signal from radio-frequency coil；Radio-frequency coil, including even number rectangle subcoil, the long limit, side of this rectangle subcoil forms first transmission line being positioned at axle center after extending, extend after the minor face bending adjacent with this long limit and form the second transmission line, several rectangle subcoils are in parallel and arrange the described radio-frequency coil of formation at equal intervals, connect through a closed loop coil after several the second transmission line other end bendings.The present invention has higher quality factor, and the radio-frequency power that can carry is 30kHz, and the uniformity of radio-frequency (RF) magnetic field is 4.6%.Achieve high-power exciting and the distribution of good radio-frequency (RF) magnetic field, substantially increase the accuracy and sensitivity of measurement.
Description
Technical field
The present invention relates to NMR analysis devices field, be specifically related to a kind of pharmaceutical nuclear magnetic resonance equipment of sensitivity.
Background technology
In view of extensive in the basic research such as chemistry, biology and clinical medicine, drug development of nuclear magnetic resonance technique
Application, various high resolution NMR analytical technologies become the important tool in Biochemical Research.Go for high-quality nuclear-magnetism
Resonance spectrogram, the parameter such as the alternating temperature performance of nuclear magnetic resonance, NMR rotor adapter, rotational stabilization seems extremely important.Especially want
Obtain high-resolution nmr spectrum, need use the bigger rotor adapter (-200 to 200 DEG C) of extent of alternating temperature and make sample
Product rotate (more than 20 rpm), now need to ensure sample tube stability when rotated.The most common rotor adapter,
The relevant parameters such as the susceptibility of its material and Mass Distribution are all unsatisfactory in large temperature range the demand used, and at height
Under rotating speed, the less stable of rotor adapter so that carry out high resolution NMR experiment process become extremely complex.
On the other hand, it is desirable to obtain high-quality nmr spectrum, the load power of NMR RF coil, radio frequency
The parameters such as magnetic field's regularity seem extremely important.Especially go for high-resolution nmr spectrum, it is often necessary to make
With the higher radio-frequency coil (more than 20kHz) of load power, geometry and space structure at this point for radio-frequency coil just carry
Go out higher requirement.The most common radio-frequency coil, such as solenoid type radio-frequency coil, and Hai Muhuozi type radio-frequency coil,
The maximum intensity of its radio-frequency field that can apply is 10 ~ 15kHz, is unsatisfactory for applying the demand of the radio-frequency field of more power so that
Carry out high resolution NMR experiment to become to be difficult to.
Summary of the invention
The present invention provides a kind of pharmaceutical nuclear magnetic resonance equipment of sensitivity, and the pharmaceutical nuclear magnetic resonance equipment of this sensitivity has
Higher quality factor, the radio-frequency power that can carry is 30kHz, and the uniformity of radio-frequency (RF) magnetic field is 4.6%.Achieve high power to swash
Send out and the distribution of good radio-frequency (RF) magnetic field, substantially increase the accuracy and sensitivity of measurement.
For reaching above-mentioned purpose, the technical solution used in the present invention is: a kind of pharmaceutical nuclear magnetic resonance equipment of sensitivity, bag
Include:
Cymometer, is used for producing RF pulse signal；
Radio-frequency oscillator, produces corresponding pulse current according to the RF pulse signal from described cymometer, and receives
From the sample feedback signal of radio-frequency coil；
Radio-frequency coil, according to the pulse current product alternating electromagnetic field from described radio-frequency oscillator, and senses generation sign sample
The sample feedback signal of product nuclear spin energy level, described radio-frequency coil includes even number rectangle subcoil, the one of this rectangle subcoil
Long limit, side forms first transmission line being positioned at axle center after extending, extend and form the second biography after the minor face bending adjacent with this long limit
Defeated line, several rectangle subcoils are in parallel and arrange the described radio-frequency coil of formation at equal intervals；
Modulator receiver, is connected to described radio-frequency oscillator, for extracting the sample feedback signal from radio-frequency oscillator;
It is positioned on described radio-frequency coil axial line for carrying the sample cell of detected sample and is positioned at immediately below it, this sample cell
It is installed on a rotor fixture；
First magnet and the second magnet lay respectively at described sample cell both sides, for providing magnetostatic to the sample in this sample cell
?；
Connect through a closed loop coil after several the second transmission line other end bendings described.
Further improvement project in technique scheme is as follows:
1., in such scheme, described rectangle subcoil number is 6, and adjacent rectangle subcoil is spaced apart 60 degree.
2., in such scheme, described scapus, upper fastener, lower fastener and cap body material are politef.
Owing to technique scheme is used, the present invention compared with prior art has following advantages and an effect:
The pharmaceutical nuclear magnetic resonance equipment of sensitivity the most of the present invention, its transmitting being applicable to pulse signal and reception, can be used for high score
Distinguish the research of nuclear magnetic resonance experiment；This apparatus structure is tight, has higher quality factor, and the radio-frequency power that can carry is
30kHz, the uniformity of radio-frequency (RF) magnetic field is 4.6%.Achieve high-power exciting and the distribution of good radio-frequency (RF) magnetic field, substantially increase
The accuracy and sensitivity measured.
The pharmaceutical nuclear magnetic resonance equipment of sensitivity the most of the present invention have employed six groups of wires, constitute with traditional one group of wire
Solenoid type coil compare with the Helmholtz coil being made up of two groups of wires, structure is finer, it is possible to realize more complicated
Radio-frequency field.
3. the coil device of the present invention achieves high power, has six subcoils, total radio frequency merit in a coil
Rate is distributed to six subcoils.In the case of each subcoil peak power is constant, improves general power, therefore improve into
The resolution of picture.
4. the coil device of the present invention improves the uniformity of radio-frequency (RF) magnetic field, have employed six subcoils, utilizes it each
Radio-frequency (RF) magnetic field mutually compensating at space overlap, improve the spatial uniformity in single coil magnetic field, improve single line
The Distribution of Magnetic Field of circle.
5. the coil device of the present invention is easy for installation, can be used directly to replace original coil, without changing other
Hardware, compared with traditional coil, this coil has had the biggest change in shape, and change based on shape, in conjunction with above-mentioned
Illustrating, this coil has following feature: (1) improves the radio-frequency power of coil；(2) improve the uniformity of magnetic field of coil；
(3) easy to install and use.
Accompanying drawing explanation
Accompanying drawing 1 is sensitivity of the present invention pharmaceutical nuclear magnetic resonance equipment principle schematic；
Accompanying drawing 2 is rectangle subcoil structural representation in radio-frequency coil of the present invention；
Accompanying drawing 3 is radio-frequency coil partial schematic diagram of the present invention；
Accompanying drawing 4 is radio-frequency coil structure schematic diagram of the present invention.
In the figures above: 1, cymometer；2, radio-frequency oscillator；3, radio-frequency coil；4, modulator receiver；5, sample cell；6、
Rotor fixture；7, rectangle subcoil；8, long limit；9, the first transmission line；10, minor face；11, the second transmission line；12, the first magnetic
Body；13, the second magnet；14, closed loop coil.
Detailed description of the invention
Below in conjunction with the accompanying drawings and embodiment the invention will be further described:
Embodiment: a kind of pharmaceutical nuclear magnetic resonance equipment of sensitivity, as shown in accompanying drawing 1 ~ 4, including:
Cymometer 1, is used for producing RF pulse signal；
Radio-frequency oscillator 2, produces corresponding pulse current according to the RF pulse signal from described cymometer, and receives
From the sample feedback signal of radio-frequency coil；
Radio-frequency coil 3, according to the pulse current product alternating electromagnetic field from described radio-frequency oscillator 2, and senses generation sign
The sample feedback signal of sample nuclear spin energy level, described radio-frequency coil 3 includes even number rectangle subcoil 7, this rectangle subcoil 7
Long limit 8, side extend after form first transmission line 9 being positioned at axle center, extend after minor face 10 bending adjacent with this long limit 8
Forming the second transmission line 11, several rectangle subcoils 7 are in parallel and arrange the described radio-frequency coil 3 of formation at equal intervals；
Modulator receiver 4, is connected to described radio-frequency oscillator 2, for extracting the sample feedback signal from radio-frequency oscillator 2;
It is positioned on described radio-frequency coil 3 axial line for carrying the sample cell 5 of detected sample and is positioned at immediately below it, this sample
Pipe is installed on a rotor fixture 6；
First magnet 12 and the second magnet 13 lay respectively at described sample cell 5 both sides, for providing to the sample in this sample cell 5
Magnetostatic field.
Connect through a closed loop coil 14 after several the second transmission line 11 other end bendings above-mentioned；The above-mentioned rectangle sub-line number of turns
Mesh is 6, and adjacent rectangle subcoil is spaced apart 60 degree.
When using the pharmaceutical nuclear magnetic resonance equipment of above-mentioned sensitivity, its transmitting being applicable to pulse signal and reception, available
Research in high resolution NMR experiment；This apparatus structure is tight, has higher quality factor, the radio-frequency power that can carry
For 30kHz, the uniformity of radio-frequency (RF) magnetic field is 4.6%.Achieve high-power exciting and the distribution of good radio-frequency (RF) magnetic field, be greatly improved
The accuracy and sensitivity measured；Secondly, nuclear magnetic resonance device have employed six groups of wires, the spiral shell constituted with traditional one group of wire
Spool type coil is compared with the Helmholtz coil being made up of two groups of wires, and structure is finer, it is possible to realize more complicated penetrating
Frequently field；Again, coil device achieves high power.Having six subcoils in a coil, total radio-frequency power is distributed to
Six subcoils.In the case of each subcoil peak power is constant, improve general power, therefore improve the resolution of imaging
Rate；Again, nuclear magnetic resonance device improves the uniformity of radio-frequency (RF) magnetic field, have employed six subcoils, utilizes its respective radio frequency
Magnetic field mutually compensating at space overlap, improves the spatial uniformity in single coil magnetic field, improves the magnetic of single coil
Field distribution.
Above-described embodiment, only for technology design and the feature of the explanation present invention, its object is to allow person skilled in the art
Scholar will appreciate that present disclosure and implements according to this, can not limit the scope of the invention with this.All according to the present invention
The equivalence that spirit is made changes or modifies, and all should contain within protection scope of the present invention.
Claims (3)
1. the pharmaceutical nuclear magnetic resonance equipment of sensitivity, it is characterised in that: including:
Cymometer (1), is used for producing RF pulse signal；
Radio-frequency oscillator (2), produces corresponding pulse current according to the RF pulse signal from described cymometer, and receives
Sample feedback signal from radio-frequency coil；
Radio-frequency coil (3), produces alternating electromagnetic field according to the pulse current from described radio-frequency oscillator (2), and senses generation
Characterizing the sample feedback signal of sample nuclear spin energy level, described radio-frequency coil (3) includes even number rectangle subcoil (7), this square
The long limit, side (8) of shape subcoil (7) forms first transmission line (9) being positioned at axle center after extending, same with this first transmission line
Extending after minor face (10) bending of side and form the second transmission line (11), several rectangle subcoils (7) are in parallel and arrange at equal intervals
Form described radio-frequency coil (3)；
Modulator receiver (4), is connected to described radio-frequency oscillator (2), feeds back for extracting the sample from radio-frequency oscillator (2)
Signal；
It is positioned on described radio-frequency coil (3) axial line for carrying the sample cell (5) of detected sample and is positioned at immediately below it, this
Sample cell is installed on a rotor fixture (6)；
First magnet (12) and the second magnet (13) lay respectively at described sample cell (5) both sides, in this sample cell (5)
Sample provides magnetostatic field；
Connect through a closed loop coil (14) after several the second transmission line (11) other end bendings described.
Nuclear magnetic resonance equipment the most according to claim 1, it is characterised in that: described rectangle subcoil (7) number is 6,
Adjacent rectangle subcoil (7) is spaced apart 60 degree.
Nuclear magnetic resonance equipment the most according to claim 1, it is characterised in that: described rotor fixture (6) material is poly-four
Fluorothene.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610445178.6A CN106153663B (en) | 2013-03-05 | 2013-03-05 | A kind of biological medicine high sensitivity nuclear magnetic resonance equipment |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610445178.6A CN106153663B (en) | 2013-03-05 | 2013-03-05 | A kind of biological medicine high sensitivity nuclear magnetic resonance equipment |
| CN201310068814.4A CN103207199B (en) | 2013-03-05 | 2013-03-05 | For the nuclear magnetic resonance device of biological medicine |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310068814.4A Division CN103207199B (en) | 2013-03-05 | 2013-03-05 | For the nuclear magnetic resonance device of biological medicine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN106153663A true CN106153663A (en) | 2016-11-23 |
| CN106153663B CN106153663B (en) | 2018-04-10 |
Family
ID=48754486
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610445226.1A Expired - Fee Related CN106168589B (en) | 2013-03-05 | 2013-03-05 | A kind of biological medicine high resolution nuclear magnetic resonance analyzer |
| CN201610445178.6A Expired - Fee Related CN106153663B (en) | 2013-03-05 | 2013-03-05 | A kind of biological medicine high sensitivity nuclear magnetic resonance equipment |
| CN201310068814.4A Expired - Fee Related CN103207199B (en) | 2013-03-05 | 2013-03-05 | For the nuclear magnetic resonance device of biological medicine |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610445226.1A Expired - Fee Related CN106168589B (en) | 2013-03-05 | 2013-03-05 | A kind of biological medicine high resolution nuclear magnetic resonance analyzer |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310068814.4A Expired - Fee Related CN103207199B (en) | 2013-03-05 | 2013-03-05 | For the nuclear magnetic resonance device of biological medicine |
Country Status (1)
| Country | Link |
|---|---|
| CN (3) | CN106168589B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108505986A (en) * | 2018-03-09 | 2018-09-07 | 中国石油天然气股份有限公司 | Nuclear magnetic resonance downhole fluid identification device and downhole fluid identification probe thereof |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106483159B (en) * | 2016-11-23 | 2018-11-13 | 青海七彩花生物科技有限公司 | A kind of biological medicine scintilla NMR analysis devices and its analysis method |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS55154449A (en) * | 1979-05-21 | 1980-12-02 | Hitachi Ltd | Nuclear magnetic resonance apparatus |
| US4275350A (en) * | 1979-05-29 | 1981-06-23 | Varian Associates, Inc. | Sample spinning mechanism for NMR probes |
| JP2005529705A (en) * | 2002-06-21 | 2005-10-06 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | Magnetic resonance imaging apparatus and method |
| CN202712411U (en) * | 2011-11-14 | 2013-01-30 | 西安电子科技大学 | Wideband dual-polarization base station antenna radiation unit |
| CN203224464U (en) * | 2013-03-05 | 2013-10-02 | 杨晓冬 | Nuclear-magnetic-resonance device for biological medicines |
-
2013
- 2013-03-05 CN CN201610445226.1A patent/CN106168589B/en not_active Expired - Fee Related
- 2013-03-05 CN CN201610445178.6A patent/CN106153663B/en not_active Expired - Fee Related
- 2013-03-05 CN CN201310068814.4A patent/CN103207199B/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108505986A (en) * | 2018-03-09 | 2018-09-07 | 中国石油天然气股份有限公司 | Nuclear magnetic resonance downhole fluid identification device and downhole fluid identification probe thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN106168589A (en) | 2016-11-30 |
| CN106153663B (en) | 2018-04-10 |
| CN103207199B (en) | 2016-05-18 |
| CN103207199A (en) | 2013-07-17 |
| CN106168589B (en) | 2018-08-17 |
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Granted publication date: 20180410 Termination date: 20190305 |