CN106483159B - A kind of biological medicine scintilla NMR analysis devices and its analysis method - Google Patents
A kind of biological medicine scintilla NMR analysis devices and its analysis method Download PDFInfo
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- CN106483159B CN106483159B CN201611038166.8A CN201611038166A CN106483159B CN 106483159 B CN106483159 B CN 106483159B CN 201611038166 A CN201611038166 A CN 201611038166A CN 106483159 B CN106483159 B CN 106483159B
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N24/00—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
- G01N24/08—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using nuclear magnetic resonance
- G01N24/087—Structure determination of a chemical compound, e.g. of a biomolecule such as a protein
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Abstract
The invention discloses a kind of biological medicine scintilla NMR analysis devices, including pedestal and analytical equipment ontology, the analytical equipment ontology is located at the top of pedestal, the top left side of the pedestal is installed with holder, cylinder body is installed on the holder, the cylinder body output end is connected with piston rod, the analytical equipment body interior offers sense channel, the sense channel is equipped with magnet up and down, sense channel is run through in described piston rod one end, and the end of the piston rod is connected with clamping device, the pedestal top right side is equipped with mounting base, display device body is equipped at the top of the mounting base.Utilize the image data method for building up of nuclear magnetic resonance, image sequence is registrated, to eliminate offset deviation existing for target area and gathered data in image sequence, data and curves are established according to the signal strength and time relationship that collect, and obtain nuclear magnetic resonance spectroscopy conclusion according to data and curves, it can be used with popularity.
Description
Technical field
The present invention relates to a kind of analytical equipments, and in particular to a kind of biological medicine scintilla NMR analysis devices.Together
When, the invention further relates to a kind of analysis methods of biological medicine scintilla NMR analysis devices.
Background technology
Nuclear magnetic resonance is the atomic nucleus that magnetic moment is not zero, and Zeeman splitting, resonance occur for the energy level that spins under external magnetic field
Absorb the physical process of the radio-frequency radiation of certain certain frequency.Nuclear magnetic resonance spectroscopy is a branch of spectroscopy, resonance frequency
For rate in radio-frequency range, corresponding transition is transition of the nuclear spin in core Zeeman level.Nuclear magnetic resonance technique has in medicine
It is widely applied, Magnetic resonance imaging (MRI) inspection has become a kind of common image check mode, and Magnetic resonance imaging is made
For a kind of novel Imaging Techniques, will not have an impact to health.
Pharmaceutical industries and the Two Mainstays that Biomedical engineering industry is modern medicine industry.Bio-pharmaceutical Industry is by biology
Technical industry is collectively constituted with medicinal industry.Various countries, each tissue do not unite to the range of definition and the delineation of biotechnology industry very much
One in addition different people viewpoint it is also usually far from each other.Biomedical engineering is integrated application life science and engineering science
Principle and method recognize human body at many levels from ergonomic point in molecule, cell, tissue, organ or even entire body system
Structure, function and other biological phenomenas, research for diseases prevention, cure the disease, bodily fuctions auxiliary and health care artificial material, system
The general name of product, device and system technology.Currently, biological medicine scintilla NMR analysis devices to biological medicine have it is important
Effect, biological medicine scintilla NMR analysis devices in the prior art are complicated for operation, displacement existing for target area
Deviation, it is difficult to meet people's demand.
Invention content
The purpose of the present invention is to provide a kind of biological medicine scintilla NMR analysis devices and its analysis method,
To solve the problems mentioned in the above background technology.
To achieve the above object, the present invention provides the following technical solutions：A kind of biological medicine scintilla nuclear magnetic resonance spectroscopy
Device, including pedestal and analytical equipment ontology, the analytical equipment ontology are located at the top of pedestal, the top left side of the pedestal
It is installed with holder, cylinder body is installed on the holder, the cylinder body output end is connected with piston rod, described point
Analysis apparatus body interior offers sense channel, and the sense channel is equipped with magnet up and down, and described piston rod one end is through inspection
Channel is surveyed, and the end of the piston rod is connected with clamping device, the pedestal top right side is equipped with mounting base, the mounting base
Top is equipped with display device body.
Preferably, the clamping device is divided into two fixtures, and spring is connected between fixture.
Preferably, card slot is also arranged on the clamping device, and the card slot is arc-shaped.
Preferably, the display device body includes mouse, keyboard and light-emitting diode display, the display device body right side
It is connected with printing equipment ontology.
The present invention also provides a kind of analysis method of biological medicine scintilla NMR analysis devices, specifically include with
Lower step：
S1, raw material preparation take 5 grams -10 grams of sample to be tested, and in a glass tube by sample to be tested encapsulation, spare；
The clamping of S2, sample to be tested make piston rod extend to the right side of analytical equipment ontology by startup cylinder body,
And it will be equipped in S1 between card slot of the glass tube clamping of sample to be tested on clamping device；
S3, manufacture resonant field, by starting analytical equipment ontology, formation is uniformly quiet between making sense channel or more magnet
Magnetic field；
S4, make piston rod that the glass tube on clamping device be driven to enter sense channel by starting cylinder body, make to be measured
The uniform magnetostatic field that sample generates in S3 carries out nuclear magnetic resonance；
S5, the image data method for building up using nuclear magnetic resonance, extract the nuclear magnetic resonance image data of target area；
S6, the image sequence in S5 is registrated, to eliminate in image sequence offset deviation existing for target area simultaneously
Gathered data；
S7, quantitative analysis calculate each area pixel mean value, and number is established according to the signal strength and time relationship that collect
According to curve；
S8, it obtains nuclear magnetic resonance spectroscopy conclusion according to the data and curves in S7, and is recorded；
S9, the printing of nuclear magnetic resonance image, collected data and nuclear magnetic resonance conclusion is bound into book form by printer.
A kind of biological medicine scintilla NMR analysis devices provided by the invention and its analysis method, with existing skill
Art is compared, and by starting cylinder body, so that piston rod is extended to the right side of analytical equipment ontology, and by the glass equipped with sample to be tested
Between card slot of the glass pipe clamping on clamping device, so that sample to be tested is carried out nuclear magnetic resonance in uniform magnetostatic field, utilize nuclear-magnetism
The image data method for building up of resonance extracts the nuclear magnetic resonance image data of target area, image sequence is registrated, to disappear
Except offset deviation existing for target area in image sequence and gathered data, according to the signal strength and time relationship collected
Data and curves are established, and nuclear magnetic resonance spectroscopy conclusion is obtained according to data and curves, can be used with popularity.
Description of the drawings
Fig. 1 is the structural diagram of the present invention；
Fig. 2 is the portions A of the present invention enlarged structure schematic diagram.
In figure：1 pedestal, 2 analytical equipment ontologies, 3 holders, 4 cylinder bodies, 5 piston rods, 6 sense channels, 7 clamping devices,
8 springs, 9 mounting bases, 10 display device bodies, 11 printing equipment ontologies, 12 magnets, 13 card slots.
Specific implementation mode
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, complete
Site preparation describes, it is clear that described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.It is based on
Embodiment in the present invention, it is obtained by those of ordinary skill in the art without making creative efforts every other
Embodiment shall fall within the protection scope of the present invention.
The present invention provides a kind of biological medicine scintilla NMR analysis devices, including pedestal 1 and analytical equipment sheet
Body 2, the analytical equipment ontology 2 are located at the top of pedestal 1, and the top left side of the pedestal 1 is installed with holder 3, described
Cylinder body 4 is installed, 4 output end of the cylinder body is connected with piston rod 5, inside the analytical equipment ontology 2 on holder 3
Sense channel 6 is offered, about 6 sense channel is equipped with magnet 12, and sense channel 6 is run through in 5 one end of the piston rod, and
The end of the piston rod 5 is connected with clamping device 7, and 1 top right side of the pedestal is equipped with mounting base 9,9 top of the mounting base
Equipped with display device body 10, the clamping device 7 is divided to for two fixtures, and spring 8 is connected between fixture, the clamping
Card slot 13 is also arranged on device 7, and the card slot 13 is arc-shaped, the display device body 10 includes mouse, keyboard
And light-emitting diode display, 10 right side of the display device body are connected with printing equipment ontology 11.
The present invention also provides a kind of analysis method of biological medicine scintilla NMR analysis devices, specifically include with
Lower step：
S1, raw material preparation take 5 grams -10 grams of sample to be tested, and in a glass tube by sample to be tested encapsulation, spare；
The clamping of S2, sample to be tested make piston rod extend to the right side of analytical equipment ontology by startup cylinder body,
And it will be equipped in S1 between card slot of the glass tube clamping of sample to be tested on clamping device；
S3, manufacture resonant field, by starting analytical equipment ontology, formation is uniformly quiet between making sense channel or more magnet
Magnetic field；
S4, make piston rod that the glass tube on clamping device be driven to enter sense channel by starting cylinder body, make to be measured
The uniform magnetostatic field that sample generates in S3 carries out nuclear magnetic resonance；
S5, the image data method for building up using nuclear magnetic resonance, extract the nuclear magnetic resonance image data of target area；
S6, the image sequence in S5 is registrated, to eliminate in image sequence offset deviation existing for target area simultaneously
Gathered data；
S7, quantitative analysis calculate each area pixel mean value, and number is established according to the signal strength and time relationship that collect
According to curve；
S8, it obtains nuclear magnetic resonance spectroscopy conclusion according to the data and curves in S7, and is recorded；
S9, the printing of nuclear magnetic resonance image, collected data and nuclear magnetic resonance conclusion is bound into book form by printer.
In conclusion compared with prior art, it is an advantage of the invention that：By starting cylinder body 4, piston rod 5 is made to stretch
It is long to the right side of analytical equipment ontology 2, and by card slot 13 of the glass tube clamping equipped with sample to be tested on clamping device 7 it
Between, so that sample to be tested is carried out nuclear magnetic resonance in uniform magnetostatic field, using the image data method for building up of nuclear magnetic resonance, extracts mesh
The nuclear magnetic resonance image data for marking region, image sequence are registrated, to eliminate position existing for target area in image sequence
Deviation and gathered data are moved, data and curves are established according to the signal strength and time relationship that collect, and according to data and curves
It obtains nuclear magnetic resonance spectroscopy conclusion, can be used with popularity.
Finally it should be noted that：The foregoing is only a preferred embodiment of the present invention, is not intended to restrict the invention,
Although the present invention is described in detail referring to the foregoing embodiments, for those skilled in the art, still may be used
With technical scheme described in the above embodiments is modified or equivalent replacement of some of the technical features,
All within the spirits and principles of the present invention, any modification, equivalent replacement, improvement and so on should be included in the present invention's
Within protection domain.
Claims (5)
1. a kind of biological medicine scintilla NMR analysis devices, including pedestal（1）With analytical equipment ontology（2）, feature
It is：The analytical equipment ontology（2）Positioned at pedestal（1）Top, the pedestal（1）Top left side be installed with holder
（3）, the holder（3）On cylinder body is installed（4）, the cylinder body（4）Output end is connected with piston rod（5）, described
Analytical equipment ontology（2）Inside offers sense channel（6）, the sense channel（6）It is equipped with magnet up and down（12）, the work
Stopper rod（5）Sense channel is run through in one end（6）, and the piston rod（5）End be connected with clamping device（7）, the pedestal（1）
Top right side is equipped with mounting base（9）, the mounting base（9）Top is equipped with display device body（10）.
2. a kind of biological medicine scintilla NMR analysis devices according to claim 1, it is characterised in that：The folder
Tight device（7）It is divided into two fixtures, and is connected with spring between fixture（8）.
3. a kind of biological medicine scintilla NMR analysis devices according to claim 1, it is characterised in that：The folder
Tight device（7）On be also arranged with card slot（13）, and the card slot（13）It is arc-shaped.
4. a kind of biological medicine scintilla NMR analysis devices according to claim 1, it is characterised in that：It is described aobvious
Showing device ontology（10）Including mouse, keyboard and light-emitting diode display, the display device body（10）Right side is connected with printing equipment
Ontology（11）.
5. a kind of analysis method of biological medicine scintilla NMR analysis devices according to claim 1, feature
It is：Specifically include following steps：
S1, raw material preparation take 5 grams -10 grams of sample to be tested, and in a glass tube by sample to be tested encapsulation, spare；
The clamping of S2, sample to be tested make piston rod extend to the right side of analytical equipment ontology, and will by starting cylinder body
In S1 between card slot of the glass tube clamping equipped with sample to be tested on clamping device；
S3, manufacture resonant field, by starting analytical equipment ontology, formation is uniformly magnetostatic between making sense channel or more magnet
?；
S4, make piston rod that the glass tube on clamping device be driven to enter sense channel by starting cylinder body, make sample to be tested
The uniform magnetostatic field generated in S3 carries out nuclear magnetic resonance；
S5, the image data method for building up using nuclear magnetic resonance, extract the nuclear magnetic resonance image data of target area；
S6, the image sequence in S5 is registrated, to eliminate offset deviation existing for target area in image sequence and acquire
Data；
S7, quantitative analysis calculate each area pixel mean value, and data song is established according to the signal strength and time relationship that collect
Line；
S8, it obtains nuclear magnetic resonance spectroscopy conclusion according to the data and curves in S7, and is recorded；
S9, the printing of nuclear magnetic resonance image, collected data and nuclear magnetic resonance conclusion is bound into book form by printer.
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| CN201611038166.8A CN106483159B (en) | 2016-11-23 | 2016-11-23 | A kind of biological medicine scintilla NMR analysis devices and its analysis method |
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| CN106483159B true CN106483159B (en) | 2018-11-13 |
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| US6972568B2 (en) * | 2003-09-09 | 2005-12-06 | Varian, Inc. | Radially-compact NMR flow cell assemblies and methods |
| JP2007003444A (en) * | 2005-06-27 | 2007-01-11 | Jeol Ltd | Cavity resonator for esr |
| CN102579047B (en) * | 2012-04-10 | 2014-12-03 | 美时医疗技术(上海)有限公司 | Special magnetic resonance imaging device for baby |
| CN103927733A (en) * | 2013-01-11 | 2014-07-16 | 上海市第六人民医院 | Method for establishing image data through nuclear magnetic resonance |
| CN106168589B (en) * | 2013-03-05 | 2018-08-17 | 杨晓冬 | A kind of biological medicine high resolution nuclear magnetic resonance analyzer |
| KR101571630B1 (en) * | 2014-07-01 | 2015-12-04 | 김동식 | A jig Oil pressure |
| CN104215539A (en) * | 2014-07-31 | 2014-12-17 | 高德（无锡）电子有限公司 | Thermal-stress testing automatic device used for PCB industry |
| CN105784749B (en) * | 2016-04-08 | 2018-01-30 | 青岛市第三人民医院 | Magnetic resonance material wave spectrogram check device |
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Effective date of registration: 20200313 Address after: 510170 No.63 xizeng Road, Liwan District, Guangzhou City, Guangdong Province Patentee after: Guangzhou Jiatu Technology Co., Ltd Address before: 810000 Qinghai province north of the city of Xining city district biological park by three road No. 7 Building No. 1 room 11118 Patentee before: QINGHAI QICAIHUA BIOTECHNOLOGY Co.,Ltd. |