CN106138647A - The liver benefiting effect of Folium Allii tuberosi and application thereof - Google Patents
The liver benefiting effect of Folium Allii tuberosi and application thereof Download PDFInfo
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- CN106138647A CN106138647A CN201510509117.7A CN201510509117A CN106138647A CN 106138647 A CN106138647 A CN 106138647A CN 201510509117 A CN201510509117 A CN 201510509117A CN 106138647 A CN106138647 A CN 106138647A
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- allii tuberosi
- folium allii
- aerial parts
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Abstract
The invention discloses the aerial parts (leaf, flower and seed) of the Folium Allii tuberosi purposes in preparing the liver benefiting effect product.With the aerial parts of Folium Allii tuberosi as raw material, the liver benefiting product of all kinds of high-quality can be effectively converted to by extraction process and processing technique, including the health-care products of human and animal and natural drug goods and medicated diet goods.
Description
Technical field
The present invention relates to aerial parts (leaf, flower and the seed) process technology of a kind of plant Folium Allii tuberosi with the liver benefiting effect and at food, health care food
Purposes in product, natural drug, specifically, is aerial parts, deep processing and the method for preparing extractive of fresh and dry Folium Allii tuberosi, the ground of Folium Allii tuberosi
Upper part deep processed product, the overground part extract of Folium Allii tuberosi, the aerial parts active chemical of Folium Allii tuberosi, the aerial parts of Folium Allii tuberosi protect the liver in preparation
Purposes in efficiency health-care product, the application in the medicine of preparation hepatitis of the aerial parts of Folium Allii tuberosi.
Background technology
Liver is one of organ important in body, subjects the processed work of substantial amounts of biochemistry factory every day, to substantial amounts of through digestion
The food that road absorbs and other foreign substance carry out the processing of metabolism, are very easy to tired and sustain damage.Hepar damnification is the serious harm people
Healthy sick kind.China has more than the hepatitis B virus lifelong carrier of 100,000,000 people, the carrier of tens million of hepatitis C virus at present, the most thousands of
Wan Renhui is transformed into chronic hepatitis, liver cirrhosis, hepatocarcinoma, and because of hepatopathy, the people of death there are about hundreds of thousands of them every year.In recent years by being addicted to drink, medicine and each
The toxic hepar damnification planting harmful factor and cause increases the most increasingly.The annual expense for treating hepatopathy of China is up to tens billion of yuans, right
The physical and mental health of economy and social development particularly patient causes the biggest burden, so keeping the health of liver to become the target that people pursue.Food
Thing and medicine are the key factors affecting liver function, thus exploitation to be of value to the food of liver health, health food and new drug the most urgent.
Folium Allii tuberosi (Allium tuberosum Rottler ex Spreng.): Folium Allii tuberosi is a kind of Liliaceae herbaceous plant.The extensively cultivation of the Folium Allii tuberosi whole nation, also has open country
Raw plant, but the area of plantation Folium Allii tuberosi does not all have the report of its anti-hepatitis.
This new use being the aerial parts (leaf, flower and seed) being found that Folium Allii tuberosi in edible, food, medicated diet, health food and medicine of the present invention
On the way, processing method and the effective ingredient etc. that contains.
Summary of the invention
It is an object of the invention to provide the new application of the aerial parts of Folium Allii tuberosi, i.e. prepare treating hepatitis medicine, health food and animal the liver benefiting product
In new opplication.
It is a further object of the present invention to provide the medicine of a kind for the treatment of hepatitis.
It is also another object of the present invention to provide the health food of a kind of hepatitis auxiliary treatment.
The purpose of the present invention also includes providing prepares good overground part extract of Folium Allii tuberosi of convenience, health care and therapeutic effect and preparation method thereof.
Inventor has carried out substantial amounts of deep processing research to the aerial parts of Folium Allii tuberosi, including Folium Allii tuberosi leaf dried powder, Folium Allii tuberosi according to the processing method of agricultural product
Flower pickles beans, Semen Allii Tuberosi powder, leek seed decoction pieces etc..
The leaf of the aerial parts of Folium Allii tuberosi and spend and can directly eat, it is also possible to directly eat its dried plant.
Inventor is with reference to " 2003 annual drug research technological guidance's principle Chinese medicine, natural goods fascicle " (State Food and Drug Administration 2003
Year), " new drug preclinical study guideline " (country Bureau of Drugs Supervision 1993) and " function of health food assessment process " (Ministry of Public Health 2003)
Deng the drug evaluation method for the treatment of hepatitis and health food evaluation methodology, the aerial parts of Folium Allii tuberosi has been carried out extract prepare, pharmaceutical dosage form system
Standby, animal pharmacology and pathological study.
Inventor finds that the aerial parts (leaf, flower and seed) of Folium Allii tuberosi has the effect of the liver benefiting.The aerial parts of Folium Allii tuberosi can make the drink of natural drug
Sheet.Can gather in Folium Allii tuberosi leaf, during the blossom season joint before flowering season can pluck Folium Allii tuberosi tongue and flower of Folium Allii tuberosi, Post flowering can gather in the crops leek seed.
After harvesting, its decoction pieces makes and is characterised by: is only made by aerial parts and is dried (including lyophilization).The aerial parts of Folium Allii tuberosi can direct using fresh herb,
Can also directly eat its dried decoction pieces.
The preparation method of the overground part extract of Folium Allii tuberosi is: can take the aerial parts decoction pieces 1000g of Folium Allii tuberosi, boiling three times, each 15
Minute, collecting decoction, filter, filtrate concentrates thick paste, continues dried, and fine powder processed to obtain final product.This product is the granule of brown；Lightly seasoned sweet.
Inventor finds, carries out oral administration and drug administration by injection with the overground part extract of Folium Allii tuberosi, has obvious effect, serum liver biochemistry
Functional parameter and pathological index all improve significantly.
When treating with the overground part extract of Folium Allii tuberosi, it can be with shapes such as powder, granule, tablet, capsule, pill and liquid preparations
Formula oral administration；Can also be with form parenteral administration such as injection, suppository, percutaneous preparation, sprays.Having of the overground part extract of Folium Allii tuberosi
Effect medicament, be by with suitable medicinal blend, be configured to such as the mixing such as excipient, binding agent, penetrating agent, lubricant.
The overground part extract dosage of Folium Allii tuberosi changes with the state of an illness, route of administration, the age of patient and the body weight of patient.In oral administration situation
Under, dosage is usually adult 300～600mg/ days, preferably 450mg/ days.Also it is same principle in health food application aspect.
The liver benefiting therapeutical effect that the invention have the advantage that the aerial parts of Folium Allii tuberosi is to find first at home and the most all so that it is become 3G food.
The aerial parts of Folium Allii tuberosi can be as the natural drug for the treatment of hepatitis.
It addition, the aerial parts preparation method of Folium Allii tuberosi is fairly simple, also comparing of plant growing the characteristic study is thorough, and there is cultivation in the whole nation, has one
The planting base of set pattern mould, so the source of material and economy are the most secure.The market recognition of natural product is higher, and the acceptance in market is high,
Good market prospects.
Detailed description of the invention
Examples provided below is used for being further elucidated with the present invention, and is not meant to limit the scope of the invention.
Embodiment 1. material
The aerial parts decoction pieces of Folium Allii tuberosi used by embodiment we self-control.Briefly, gather in the crops Folium Allii tuberosi (leaf), summer and autumn spring and mainly gather in the crops flower
Piece.Autumn gathers in the crops leek seed.Other medicine, reagent and laboratory animal, can be the most commercial.
Embodiment 2. preparation method example
Take the decoction pieces 1000g of the aerial parts of Folium Allii tuberosi, the 2500ml that adds water to decoct, totally three times, each 15 minutes, collecting decoction, filter, filter
Liquid is condensed into thick paste, continues to be evaporated to do, obtains brown ceramic powder.
Embodiment 3. example of formulations,
(1) take the overground part extract that the preparation method of 1kg embodiment 2 obtains the Folium Allii tuberosi of each plant parts, pulverize and cross 100 mesh sieves,
Add appropriate amount of starch mixing, prepare granule, after granulate, carry out subpackage, every bag of 2g.
(2) overground part extract 1000g, the hydroxyethyl cellulose 10g of the Folium Allii tuberosi that the preparation method of Example 2 obtains, sheet made by tabletting
Agent.
(3) overground part extract of the Folium Allii tuberosi that the preparation method of embodiment 2 obtains is dissolved in normal saline or isotonic Glucose Liquid, presses after filtering
Need to use the injection of preparation.
(4) overground part extract of the Folium Allii tuberosi that the preparation method of embodiment 2 obtains is dissolved in water, can be formulated directly into oral liquid.
(5) overground part extract of the Folium Allii tuberosi that the preparation method of embodiment 2 obtains can coordinate with the medicine such as Radix Isatidis extract and makes compound recipe and close
Agent is used for treating hepatitis.
Embodiment 4. effect experiment
(1) evaluation methodology
The aerial parts of Folium Allii tuberosi and the drug efficacy study part of extract for treating hepatitis thereof
Laboratory animal is adult healthy male CD-1 mice.Enough tap waters and normal diet are provided during test.The packet of animal will with process
Mice presses body weight random packet.For to be administered for three days on end in the observation of curative effect of hepatitis, once a day.Within 4th day, take blood and leave and take animal livers, surveying
Determine liver function enzyme alanine transaminase (ALT) in serum, observe hepatic pathology intensity of variation.Experimental data represents with mean ± standard deviation.Application
Experimental result is used the methods analyst such as variance analysis, t inspection to process by EXCEL statistical software, and p ＜ 0.05 thinks that group difference has significance.
(2) evaluation result (table 1-4): Folium Allii tuberosi leaf, flower of Folium Allii tuberosi, Semen Allii Tuberosi all have the good effect protecting the liver anti-toxic hepatitis.
The effect of table 1 Allium tubersum rottl extract anti-carbon tetrachloride poisoning hepatitis
Note:##P ＜ 0.01 is compared with matched group.* compares p ＜ 0.01 with poisoning hepatitis model group.
The effect of table 2 Allium tubersum rottl extract anti-acetaminophen toxic hepatitis
Note:##P ＜ 0.01 is compared with matched group.* compares p ＜ 0.01 with poisoning hepatitis model group.
The effect of table 3 Folium Allii tuberosi leaf extract anti-thioacetamide toxic hepatitis
Note:#P ＜ 0.05 is compared with matched group.* p ＜ 0.01 is compared with poisoning hepatitis model group.
The effect of table 4 flower of Folium Allii tuberosi extract anti-thioacetamide toxic hepatitis
Note:##P ＜ 0.05 is compared with matched group.* compares p ＜ 0.01 with poisoning hepatitis model group.
Claims (7)
1. for preparation, there is the plant product to human and animal's the liver benefiting effect, it is characterised in that aerial parts (leaf, flower and seed) containing Folium Allii tuberosi or
Extract.
2. aerial parts (leaf, flower and the seed) decoction pieces of a Folium Allii tuberosi, it is characterised in that the aerial parts (leaf, flower and seed) of Folium Allii tuberosi can be made natural
Decoction pieces.The aerial parts of Folium Allii tuberosi can direct using fresh herb, it is also possible to directly its dried decoction pieces edible.
3. the overground part extract of a Folium Allii tuberosi, it is characterised in that adopt and prepare with the following method, takes the decoction pieces of the aerial parts of Folium Allii tuberosi or fresh portion
Point, only to make, boiling three times, each 15 minutes, collecting decoction, filter, filtrate concentrates thick paste.Or thick paste is dried, prepare thin
Powder.
The overground part extract of Folium Allii tuberosi the most according to claim 3, it is characterised in that extract fine powder can be made together with suitable medical dressing
Become the multiple dosage forms such as oral formulations, injection, granule, tablet, capsule, pill, powder.Can also with other medicines or other plant
Thing extract compatibility composition compound preparation.
5. the medicine for hepatitis auxiliary treatment, it is characterised in that the aerial parts decoction pieces containing the Folium Allii tuberosi described in claim 2 and 3 or extract.
6. the health product for the liver benefiting, it is characterised in that the aerial parts decoction pieces containing the Folium Allii tuberosi described in claim 2 and 3 or extract.
7. the aerial parts of Folium Allii tuberosi or the aerial parts decoction pieces of the Folium Allii tuberosi described in claim 2 and 3 or extract are in the medicine of preparation hepatitis and health care
Application in product and medicated diet.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510509117.7A CN106138647A (en) | 2015-08-19 | 2015-08-19 | The liver benefiting effect of Folium Allii tuberosi and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201510509117.7A CN106138647A (en) | 2015-08-19 | 2015-08-19 | The liver benefiting effect of Folium Allii tuberosi and application thereof |
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| CN106138647A true CN106138647A (en) | 2016-11-23 |
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| CN201510509117.7A Withdrawn CN106138647A (en) | 2015-08-19 | 2015-08-19 | The liver benefiting effect of Folium Allii tuberosi and application thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107496485A (en) * | 2017-09-29 | 2017-12-22 | 北京健旭康技术有限公司 | The beneficial liver effect of pilose gerbera herb and application technology |
-
2015
- 2015-08-19 CN CN201510509117.7A patent/CN106138647A/en not_active Withdrawn
Non-Patent Citations (2)
| Title |
|---|
| 樊蔚虹编著: "《肝病饮食养生宝典》", 31 May 2013, 陕西科学技术出版社 * |
| 赵国东编著: "《肝病怎样吃最健康》", 31 January 2014, 河北科学技术出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107496485A (en) * | 2017-09-29 | 2017-12-22 | 北京健旭康技术有限公司 | The beneficial liver effect of pilose gerbera herb and application technology |
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Application publication date: 20161123 |
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