CN104095905A - Leguminosae plant with liver-tonifying effect and application thereof - Google Patents
Leguminosae plant with liver-tonifying effect and application thereof Download PDFInfo
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- CN104095905A CN104095905A CN201310118194.0A CN201310118194A CN104095905A CN 104095905 A CN104095905 A CN 104095905A CN 201310118194 A CN201310118194 A CN 201310118194A CN 104095905 A CN104095905 A CN 104095905A
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Abstract
The invention discloses application of eguminosae plant with liver-tonifying effect to preparation of liver-tonifying products. Leguminosae Caragana Caragana Fabr. plant seeds liver-tonifying beans are used as raw materials, which can be effectively converted into many kinds of excellent liver-tonifying products, including human and animal health food products and natural medicinal products through the extraction process and processing process.
Description
Technical field
The present invention relates to an accessory have the liver benefiting effect pulse family population pattern change seed process technology and at food, health food, natural drug, purposes in animal use health product and once medicine, specifically, it is fresh and dry Caragana seed, deep processing and method for preparing extractive, deep processed product, Caragana seed extract, Caragana seed active chemical, the purposes of Caragana seed in preparing liver-protecting efficacy health product, the application of Caragana seed in the medicine (I class and II class new natural drug) of preparation hepatitis and the application of animal the liver benefiting goods (as prevented and treated animal hepatitis etc.).
Background technology
Liver is one of important Functional tissue in human and animal's body, bearing a large amount of biochemistry treatment and processing work every day, the a large amount of food and the feedstuff that through digestive tract, absorb are carried out to various processing metabolism, be very easy to fatigue and be subject to the various former damages of causing a disease.Hepar damnification is the disease kind of serious harm people ' s health, and at present known hepatic injury is caused a disease and formerly had thousands of kinds.China has the hepatitis B virus lifelong carrier over 100,000,000 people, the carrier of tens million of hepatitis C viruss at present.In recent years by being addicted to drink, medicine and various harmful factor and the toxic hepar damnification that causes also increase increasingly.In hepatopath, tens of millions of people can be transformed into chronic hepatitis, liver cirrhosis, hepatocarcinoma, every year because the dead people of hepatopathy approximately has hundreds of thousands of them.The expense that China is used for the treatment of hepatopathy is every year up to tens billion of yuans, to economy and social development particularly patient's physical and mental health caused very large burden, so keep the health of liver to become the target that people pursue.Food is the key factor that affects liver function, so that exploitation is of value to food, health food and the new drug of liver health is just very urgent.
Caragana (Caragana Fabr.) is the platymiscium in leguminous plant.Area at population pattern changes such as Beijing does not all eat custom and the research report of the liver benefiting bean.The < < agricultural plant type named regulation > > of Gen Jue Ministry of Agriculture issue, we think that caragana seed belongs to a kind of pulse family new varieties of agricultural plant of new resource food." the liver benefiting bean " is that we have found that profit of this platymiscium has the name rising after good the liver benefiting effect.
In addition, the liver benefiting bean food, health food and oral medicine with aspect all there is no application, the present invention has found new purposes, the processing method of the liver benefiting bean in edible, food, health food and medicine and the effective ingredient that contains etc. just.
Summary of the invention
The new purposes that the object of this invention is to provide the liver benefiting bean, i.e. new application in preparing treating hepatitis medicine, health food and animal the liver benefiting product.
Another object of the present invention is to provide a kind of natural drug for the treatment of hepatitis.
A further object of the present invention is to provide a kind of health food of hepatitis auxiliary treatment.
Object of the present invention also comprises provides easy to prepare, health care and the good the liver benefiting bean extract of therapeutic effect and preparation method thereof.
Inventor has carried out a large amount of deep processing research according to the processing method of agricultural product to the liver benefiting bean herb and each position, comprises the liver benefiting bean medicated porridge, the liver benefiting bean soup, dry the liver benefiting bean, the liver benefiting Semen Glycines powder, instant the liver benefiting bean, the liver benefiting bean beverage (as the liver benefiting bean coffee), the liver benefiting bean wine, the liver benefiting Semen Glycines powder goods (as cookies, bread, noodles, bean curd etc.), the liver benefiting bean decoction pieces, the liver benefiting bean extract, the liver benefiting bean confection and dessert etc.
The liver benefiting bean can directly eat, the liver benefiting bean that also can directly eat its dry baking or fry.
Inventor is with reference to the annual drug research technological guidance of < < 2003 principle-Chinese medicine, natural drug fascicle > > (State Food and Drug Administration 2003), drug evaluation method and the health food pricing method of the treating hepatitis of < < new drug preclinical study guideline > > (national Bureau of Drugs Supervision 1993) and < < function of health food assessment process > > (Ministry of Public Health 2003) etc., the liver benefiting bean has been carried out to extract preparation, pharmaceutical dosage form preparation, animal pharmacology and pathological study.
Inventor finds that the liver benefiting bean has the effect of the liver benefiting.The liver benefiting bean can be made the decoction pieces of natural drug.In summer and autumn, the liver benefiting bean is gathered in to collection.The liver benefiting bean decoction pieces is made and dry seed only to seed.
The preparation method of the liver benefiting bean extract is: can get the liver benefiting bean decoction pieces 1000g, do not pulverize or pulverize, decoct with water three times, each 15 minutes, collecting decoction, filtered, and filtrate concentrates thick paste, and after continuing to be dried, fine powder processed, obtains.This product is brown granule; Mildly bitter flavor.
Inventor finds, with the liver benefiting bean extract, carries out oral administration and drug administration by injection, has obvious effect, and serum liver biochemical function index and pathological index all improve significantly.
While treating with the liver benefiting bean extract, it can be with form oral administrations such as powder, granule, tablet, capsule, pill and liquid preparations; Also can be non-through enteral administration with forms such as injection, suppository, percutaneous preparation, sprays.The effective agent of the liver benefiting bean extract, is by the medicinal blend with suitable, as mixing such as excipient, binding agent, penetrating agent, lubricants, is mixed with.
The liver benefiting bean extract doses changes with route of administration, patient's age and body weight.In oral administration situation, dosage is generally adult 400～800mg/ days, is preferably 500mg/ days.It aspect health food and food applications, is being also same principle.
Advantage of the present invention is: the liver benefiting therapeutical effect of the liver benefiting bean is all to find first at home and in the world.The liver benefiting bean can be used as the natural drug for the treatment of hepatitis, treatment liver cirrhosis.At present, also there is no in the world generally acknowledged liver cirrhosis medicine.
In addition, the liver benefiting bean preparation method is fairly simple, and plant growing the characteristic study also more thorough also had the plantation of certain scale, so the source of material and economy are all secure.The market recognition of natural product is higher, market high by degree of being subject to, good market prospects.
The specific embodiment
The embodiment providing is below for further illustrating the present invention, and do not form limitation of the scope of the invention.
Embodiment 1. materials
We make by oneself embodiment the liver benefiting bean used decoction pieces.The liver benefiting bean using has the seed of Beijing caragana (Caragana pekinensis) seed, Caragana korshinskii (Caragana korshinskii) seed and littleleaf peashrub (Caragana microphylla) etc.We have worked out the GMP operation standard of different the liver benefiting pea green plantations and the GAP operation standard of results and the making of pharmaceutical decocting piece.Briefly, the decoction pieces of seed is made and will and be cleaned operation through super-dry.
Other medicine, reagent and laboratory animal, can be commercial easily.
Embodiment 2. preparation method examples
Get the decoction pieces 1000g of the liver benefiting bean herb, pulverize, wash 3 times, add water 2500ml and decoct, totally three times, each 20 minutes, collecting decoction, filtration, it is 1.19 thick paste that filtrate is condensed into relative density, continues to be evaporated to dry, obtains brown ceramic powder 55g.
Embodiment 3. FORMULATION EXAMPLE,
(1) preparation method of getting 1kg embodiment 2 obtains the liver benefiting bean extract of each plant parts, pulverizes and cross 100 mesh sieves, enters appropriate amount of starch and mixes, and prepares granule, carries out subpackage, every bag of 2g after granulate.
(2) get the liver benefiting bean extract 1000g of the preparation method acquisition of embodiment 2, hydroxyethyl-cellulose 10g, tabletting is made tablet.
(3) the liver benefiting bean extract that the preparation method of embodiment 2 obtains is dissolved in normal saline or waits and oozes Glucose Liquid, uses on demand later after filtration the injection of preparing.
(4) the liver benefiting bean extract that the preparation method of embodiment 2 obtains is water-soluble, can directly be mixed with oral liquid.
(5) the liver benefiting bean extract that the preparation method of embodiment 2 obtains can coordinate and make compound mixture for preventing and treating hepatitis with the medicine such as Radix Glycyrrhizae extract, Radix Isatidis extract.
(6) the liver benefiting bean extract powder that the preparation method of embodiment 2 obtains mixes with coffee powder, can directly be mixed with composite beverage and instant drink.
(7) the liver benefiting bean extract powder that the preparation method of embodiment 2 obtains mixes with Amylum Nelumbinis Rhizomatis, black sesame powder, starch etc., can process food and the health food of dosage forms such as being mixed with composite the liver benefiting bean paste and cookies.
Embodiment 4. eating effect experiments
(1) evaluation methodology
The drug efficacy study part of the liver benefiting bean and extract for treating hepatitis thereof
Laboratory animal is the male CD-1 mice of adult healthy.Duration of test provides enough tap water and normal diet.Mice is pressed to body weight random packet.In the observation of curative effect of toxic hepatitis, be administration for three days on end, once a day.Within the 4th day, get blood and leave and take animal livers, measure the liver function enzyme alanine transaminase (ALT) in serum, observe hepatic pathology intensity of variation.Administration time while carrying out the evaluation of N-nitrosodimethylamine cirrhosis treatment is 2 months, measures afterwards the fibrosis index (hydroxyproline) in liver organization.
The pick of experiment number represents with mean ± standard deviation.Application EXCEL statistical software adopts the methods analysts such as variance analysis, t check to process to experimental result, p < 005 thinks that group difference has significance.
(2) evaluation result:
The effect of the anti-carbon tetrachloride poisoning hepatitis of table 1 the liver benefiting bean (caragana seed) extract
Note:
##compare p < 0.01 with matched group.
*compare p < 0.01 with model group.
The effect of the anti-mice N-nitrosodimethylamine acute toxic hepatitis of table 2 the liver benefiting bean (littleleaf peashrub seed)
Note:
#compare p < 0.05 with matched group.*,
*compare p < 0.05, p < 0.01 with model group.
The effect of the anti-N-nitrosodimethylamine liver cirrhosis of table 3 the liver benefiting bean (littleleaf peashrub seed) extract
Note:
##compare p < 0.01 with matched group.*,
*compare p < 0.05, p < 0.01 with model group.
Claims (8)
1. for the preparation of human and animal being there is to the plant product of the liver benefiting effect, it is characterized in that the extract that contains the liver benefiting bean (seed of population pattern change).
2. a liver benefiting bean decoction pieces, is characterized in that the liver benefiting bean can make natural decoction pieces.Its decoction pieces is made and is characterised in that: the liver benefiting bean seed decoction pieces is clean system and dry.The liver benefiting bean is using fresh herb directly, also can directly eat its dried decoction pieces.
3. a liver benefiting bean extract, is characterized in that adopting with the following method and prepares, and gets the liver benefiting bean, pulverizes or does not pulverize, and decocts with water three times, and each 15 minutes, collecting decoction, filtered, and filtrate concentrates thick paste.Or after thick paste is dry, make fine powder.
4. the liver benefiting bean extract according to claim 3, its feature can made the multiple dosage forms such as oral formulations, injection, granule, tablet, capsule, pill, powder with extract fine powder together with suitable medical dressing.Also can form compound preparation with other medicines or other plant extract compatibility.
5. for a medicine for hepatitis control, it is characterized in that containing the liver benefiting bean decoction pieces or extract described in claim 2 and 3.
6. for health product for the liver benefiting, it is characterized in that containing the liver benefiting bean decoction pieces or extract described in claim 2 and 3.
7. the liver benefiting bean decoction pieces described in the liver benefiting bean or claim 2 and 3 or extract are in the medicine of preparation hepatitis and the application in health product.
8. the liver benefiting bean decoction pieces described in the liver benefiting bean or claim 2 and 3 or extract are being prepared the medicine of liver cirrhosis and the application in health product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310118194.0A CN104095905A (en) | 2013-04-08 | 2013-04-08 | Leguminosae plant with liver-tonifying effect and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201310118194.0A CN104095905A (en) | 2013-04-08 | 2013-04-08 | Leguminosae plant with liver-tonifying effect and application thereof |
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| CN104095905A true CN104095905A (en) | 2014-10-15 |
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| CN201310118194.0A Pending CN104095905A (en) | 2013-04-08 | 2013-04-08 | Leguminosae plant with liver-tonifying effect and application thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105998564A (en) * | 2015-07-20 | 2016-10-12 | 北京健旭康技术有限公司 | Allium plant with liver benefiting function and application thereof |
| CN106727872A (en) * | 2017-01-20 | 2017-05-31 | 北京健旭康技术有限公司 | The beneficial liver effect of poinsettia and application technology |
| CN107536891A (en) * | 2017-09-29 | 2018-01-05 | 北京健旭康技术有限公司 | The beneficial liver effect of boenninghausenia sessilicarpa and application technology |
-
2013
- 2013-04-08 CN CN201310118194.0A patent/CN104095905A/en active Pending
Non-Patent Citations (5)
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| 小叶锦鸡儿种子中的生物碱及其细胞毒活性;张国庆等;《药学实践杂志》(第02期);105-106 * |
| 张国庆等: "小叶锦鸡儿种子中的生物碱及其细胞毒活性 ", 《药学实践杂志》 * |
| 金桂林: "柠条籽化学成分及生物活性研究", 《中国优秀硕士学位论文全文数据库》 * |
| 霍炎: "柠条籽镇痛及抗肿瘤物质基础研究", 《中国优秀博硕士学位论文全文数据库 (硕士) 医药卫生科技辑》 * |
| 霍炎: "柠条籽镇痛及抗肿瘤物质基础研究", 《中国优秀硕士学位论文全文数据库》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105998564A (en) * | 2015-07-20 | 2016-10-12 | 北京健旭康技术有限公司 | Allium plant with liver benefiting function and application thereof |
| CN106727872A (en) * | 2017-01-20 | 2017-05-31 | 北京健旭康技术有限公司 | The beneficial liver effect of poinsettia and application technology |
| CN107536891A (en) * | 2017-09-29 | 2018-01-05 | 北京健旭康技术有限公司 | The beneficial liver effect of boenninghausenia sessilicarpa and application technology |
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Application publication date: 20141015 |