CN106109506A - A kind of Periostracum cicadae micropowder tablet and preparation method thereof - Google Patents
A kind of Periostracum cicadae micropowder tablet and preparation method thereof Download PDFInfo
- Publication number
- CN106109506A CN106109506A CN201610567605.8A CN201610567605A CN106109506A CN 106109506 A CN106109506 A CN 106109506A CN 201610567605 A CN201610567605 A CN 201610567605A CN 106109506 A CN106109506 A CN 106109506A
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- China
- Prior art keywords
- periostracum cicadae
- tablet
- micropowder
- tabletting
- preparation
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- 238000002360 preparation method Methods 0.000 title claims abstract description 12
- 239000000843 powder Substances 0.000 claims abstract description 21
- 238000007908 dry granulation Methods 0.000 claims abstract description 15
- 230000036316 preload Effects 0.000 claims abstract description 11
- 238000000034 method Methods 0.000 claims abstract description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 9
- 239000002245 particle Substances 0.000 claims abstract description 6
- 238000007873 sieving Methods 0.000 claims abstract description 3
- 239000003826 tablet Substances 0.000 claims description 32
- 229940046011 buccal tablet Drugs 0.000 claims description 3
- 239000006189 buccal tablet Substances 0.000 claims description 3
- 238000004090 dissolution Methods 0.000 abstract description 4
- 241000190633 Cordyceps Species 0.000 description 5
- 239000008213 purified water Substances 0.000 description 4
- 241001625026 Cordyceps cicadae Species 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 238000009395 breeding Methods 0.000 description 2
- 230000001488 breeding effect Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 235000016709 nutrition Nutrition 0.000 description 2
- KQLDDLUWUFBQHP-UHFFFAOYSA-N Cordycepin Natural products C1=NC=2C(N)=NC=NC=2N1C1OCC(CO)C1O KQLDDLUWUFBQHP-UHFFFAOYSA-N 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 241000167880 Hirundinidae Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000036592 analgesia Effects 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 238000010420 art technique Methods 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- OFEZSBMBBKLLBJ-BAJZRUMYSA-N cordycepin Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)C[C@H]1O OFEZSBMBBKLLBJ-BAJZRUMYSA-N 0.000 description 1
- OFEZSBMBBKLLBJ-UHFFFAOYSA-N cordycepine Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(CO)CC1O OFEZSBMBBKLLBJ-UHFFFAOYSA-N 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000004438 eyesight Effects 0.000 description 1
- 230000035784 germination Effects 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 235000013402 health food Nutrition 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000003907 kidney function Effects 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 230000000877 morphologic effect Effects 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 238000005453 pelletization Methods 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000004223 radioprotective effect Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000007958 sleep Effects 0.000 description 1
- 230000009747 swallowing Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/062—Ascomycota
- A61K36/066—Clavicipitaceae
- A61K36/068—Cordyceps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Mycology (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The present invention relates to a kind of Periostracum cicadae micropowder tablet and preparation method thereof.A kind of Periostracum cicadae micropowder tablet, uses water content 5 15%, and mesh number is 1,000 10000 mesh, and particle diameter is the tablet that the Periostracum cicadae micropowder of 1.5 15 microns is prepared from.The preparation method of a kind of Periostracum cicadae micropowder tablet, it comprises the following steps: 1) Periostracum cicadae being crushed to particle diameter is 1.5 15 microns, and moisture Control is 5 15%；2) by crossing 30 60 mesh sieves after the Periostracum cicadae dry granulation in step 1), carrying out tabletting after sieving, the method for described tabletting is precompressed Periostracum cicadae powder before tabletting, and wherein preload pressure is 0.8 30kN, principal pressure 30 80kN.Powder diameter before the Periostracum cicadae tabletting of the present invention is 1.5 15 microns, and dissolution rate is the highest, and dissolution time is fast, and bioavailability is high.
Description
Technical field
The invention belongs to the field of health food, particularly relate to a kind of Periostracum cicadae micropowder tablet and preparation method thereof.
Background technology
Periostracum cicadae is tame Cordyceps cicadae Shing (Isaria cicadae Miquel), is commonly called as big Cordyceps, belongs to worm raw
Fungus, in 504 kinds of Cordycepses that the whole world has been found that, Periostracum cicadae, Cordyceps are only two kinds therein；It is outside one
Shape has the marvellous biology of " animal " and " plant " morphological characteristic, and root is the larva body of Cicadae, and flower is from single or 2-3 Cicadae children
Worm head grows out, and about one-inch is how long, and from top, branch is bloomed, and pollen is that milk yellow is also referred to as " Periostracum cicadae spore powder ", letter
Singly say to be exactly " seed ", there is breeding function.Its forming process is that the larva of Cicadae is infected by Cordyceps, posts before Cicadae sprouts wings
Raw, when climatic environment is suitable, the nutrition absorbing polypide changes into mycelium, and final polypide is accounted for tool completely by mycelium and only remains
The next body.In all things on earth recovery time, mycelium gradates from the vegetative phase again has breeding function for the perfect stage " Cicadae
Flower spore powder ", gradually from top branch " germination " likeness in form flower, so also referred to as Periostracum cicadae.It is distributed in the Sichuan of China, Jiangsu, Zhejiang
River, Fujian, Anhui, Yunnan Province.The active ingredient of Periostracum cicadae has: cordycepin, Cordyceps polysaccharide, cordycepic acid.Periostracum cicadae has
High immunity, improve renal function, resisting fatigue, blood fat reducing, blood sugar lowering, blood pressure lowering, antitumor, improving eyesight, improvement sleep, radioprotective,
Analgesia, calmness.So far, market yet there are no the product of Periostracum cicadae tablet, more have no individually with Periostracum cicadae medical material system
The product of standby tablet.
Summary of the invention
In order to overcome the deficiency of above-mentioned prior art, first purpose of the present invention is to provide a kind of only Periostracum cicadae medicine
Material powder, is not added with the tablet of any adjuvant, and second purpose is to provide the preparation method of a kind of Periostracum cicadae micropowder tablet.
In order to realize above-mentioned first purpose, present invention employs following technical scheme:
A kind of Periostracum cicadae micropowder tablet, uses water content 5-15%, and mesh number is 1000-10000 mesh, and particle diameter is 1.5-15 micron
The tablet that Periostracum cicadae micropowder is prepared from.
Preferably: the water content 7% of Periostracum cicadae micropowder.
Preferably: described tablet is buccal tablet or swallows tablet.
In order to realize above-mentioned second purpose, present invention employs following technical scheme:
A kind of preparation method of Periostracum cicadae micropowder tablet, it comprises the following steps:
1) Periostracum cicadae being crushed to particle diameter is 1.5-15 micron, and moisture Control is at 5-15%；
2) by crossing 30-60 mesh sieve after the Periostracum cicadae dry granulation in step 1), tabletting, the method for described tabletting after sieving, are carried out
For precompressed Periostracum cicadae powder before tabletting, wherein preload pressure is 0.8-30kN, principal pressure 30-80kN.
Preferably: the method for described tabletting is precompressed Periostracum cicadae powder before tabletting, and wherein preload pressure is
1.0kN, principal pressure 60kN.
Powder diameter before the Periostracum cicadae tabletting of the present invention is 1.5-15 micron, and dissolution rate is the highest, and dissolution time is fast, raw
Thing availability is high.Owing to powder diameter is less, powder surface tension is relatively big, and powder voids is very big, utilizes conventional pressed-disc technique
Being unable to reach, the present invention uses the world's state-of-the-art technique dry granulation, powder is pressed into graininess, then carries out tabletting.Dry
Method facility for granulating uses low temperature pressing, and temperature is less than 80 DEG C, it is to avoid the high temperature destruction to nutritional labeling；The present invention provides
Its tablet quality of tablet meet the tablet general rule requirement in galenic pharmacy.
Detailed description of the invention
The invention provides a kind of Periostracum cicadae micropowder tablet and preparation method thereof: carry out after Periostracum cicadae is crushed to micropowder
Dry granulation, then carry out formation tablet after precompressed, main pressure, described tablet is for swallowing tablet, it is also possible to be buccal tablet.Institute of the present invention
The tablet stated completes tabletting in the case of being not added with any adjuvant, and the state-of-the-art equipment in the world today that have employed carries out dry method
Pelletizing, obtained tablet moisture is less than 15%, belongs to Periostracum cicadae pure powder tablet preparation.
Below by way of example Periostracum cicadae micropowder tablet of the present invention and preparation method thereof is described:
Embodiment 1 takes 1000 mesh Periostracum cicadae powder 1000g, and moisture Control, 5%, carries out dry granulation, needs during dry granulation
Adding purified water 20g, carry out tabletting after having pelletized, preload pressure is 1.5kN, and main pressure pressure is 30kN；
Embodiment 2 takes 2000 mesh Periostracum cicadae powder 1000g, and moisture Control, 8%, carries out dry granulation, needs during dry granulation
Adding purified water 10g, carry out tabletting after having pelletized, preload pressure is 10kN, and main pressure pressure is 40kN；
Embodiment 3 takes 3000 mesh Periostracum cicadae powder 1000g, and moisture Control, 10%, carries out dry granulation, during dry granulation
Need to add purified water 10g, carry out tabletting after having pelletized, preload pressure is 20kN, and main pressure pressure is 50kN；
Embodiment 4 takes 5000 mesh Periostracum cicadae powder 1000g, and moisture Control, 10%, carries out dry granulation, during dry granulation
Need to add purified water 10g, carry out tabletting after having pelletized, preload pressure is 30kN, and main pressure pressure is 60kN；
Embodiment 5 takes 10000 mesh Periostracum cicadae powder 1000g, and moisture Control, 15%, carries out dry granulation, after having pelletized
Carrying out tabletting, preload pressure is 10kN, and main pressure pressure is 60kN；
Embodiment 6 takes 10000 mesh Periostracum cicadae powder 1000g, and moisture Control, 15%, carries out dry granulation, after having pelletized
Carrying out tabletting, preload pressure is 30kN, and main pressure pressure is 80kN；
The tablet prepared by above example, its prescription meets tablet standard in pharmaceutics, and the core of the present invention is
Solve the problem in Conventional compression by advanced technology with equipment so that impossible technique is possibly realized, use suitably
Equipment feasibility is strong.
Claims (5)
1. a Periostracum cicadae micropowder tablet, it is characterised in that: using water content 5-15%, mesh number is 1000-10000 mesh, and particle diameter is
The tablet that the Periostracum cicadae micropowder of 1.5-15 micron is prepared from.
A kind of Periostracum cicadae micropowder tablet the most according to claim 1, it is characterised in that: the water content of Periostracum cicadae micropowder
7%。
A kind of Periostracum cicadae micropowder tablet the most according to claim 1 and 2, it is characterised in that: described tablet be buccal tablet or
Swallow tablet.
4. the preparation method of a Periostracum cicadae micropowder tablet, it is characterised in that: it comprises the following steps:
1) Periostracum cicadae being crushed to particle diameter is 1.5-50 micron, and moisture Control is at 5-15%；
2) by crossing 30-60 mesh sieve after the Periostracum cicadae dry granulation in step 1), tabletting, the method for described tabletting after sieving, are carried out
For precompressed Periostracum cicadae powder before tabletting, wherein preload pressure is 0.8-30kN, principal pressure 30-80kN.
The preparation method of a kind of Periostracum cicadae micropowder tablet the most according to claim 4, it is characterised in that: the side of described tabletting
Method is precompressed Periostracum cicadae powder before tabletting, and wherein preload pressure is 1.0kN, principal pressure 60kN.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610567605.8A CN106109506A (en) | 2016-07-19 | 2016-07-19 | A kind of Periostracum cicadae micropowder tablet and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610567605.8A CN106109506A (en) | 2016-07-19 | 2016-07-19 | A kind of Periostracum cicadae micropowder tablet and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106109506A true CN106109506A (en) | 2016-11-16 |
Family
ID=57289514
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610567605.8A Pending CN106109506A (en) | 2016-07-19 | 2016-07-19 | A kind of Periostracum cicadae micropowder tablet and preparation method thereof |
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| Country | Link |
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| CN (1) | CN106109506A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107183676A (en) * | 2017-04-17 | 2017-09-22 | 安徽虫草源生物科技有限公司 | A kind of Periostracum cicadae lozenge and preparation method thereof |
| CN108719559A (en) * | 2017-04-25 | 2018-11-02 | 浙江泛亚生物医药股份有限公司 | A kind of Periostracum cicadae nougat and preparation method thereof |
| CN113317503A (en) * | 2021-06-20 | 2021-08-31 | 王维义 | Cordyceps cicadae fruiting body-based blood sugar reducing composition and preparation method and application thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101332212A (en) * | 2007-09-30 | 2008-12-31 | 张雪峰 | Aweto micropowder tablet and preparation method thereof |
| CN103417582A (en) * | 2013-07-29 | 2013-12-04 | 曹静 | Cordyceps sinensis pure powder tablet and preparation method thereof |
| CN103784487A (en) * | 2014-03-07 | 2014-05-14 | 山东东阿阿胶股份有限公司 | Ginseng micro-powder tablet and preparation method thereof |
-
2016
- 2016-07-19 CN CN201610567605.8A patent/CN106109506A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101332212A (en) * | 2007-09-30 | 2008-12-31 | 张雪峰 | Aweto micropowder tablet and preparation method thereof |
| CN103417582A (en) * | 2013-07-29 | 2013-12-04 | 曹静 | Cordyceps sinensis pure powder tablet and preparation method thereof |
| CN103784487A (en) * | 2014-03-07 | 2014-05-14 | 山东东阿阿胶股份有限公司 | Ginseng micro-powder tablet and preparation method thereof |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107183676A (en) * | 2017-04-17 | 2017-09-22 | 安徽虫草源生物科技有限公司 | A kind of Periostracum cicadae lozenge and preparation method thereof |
| CN108719559A (en) * | 2017-04-25 | 2018-11-02 | 浙江泛亚生物医药股份有限公司 | A kind of Periostracum cicadae nougat and preparation method thereof |
| CN113317503A (en) * | 2021-06-20 | 2021-08-31 | 王维义 | Cordyceps cicadae fruiting body-based blood sugar reducing composition and preparation method and application thereof |
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| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20161116 |
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| RJ01 | Rejection of invention patent application after publication |