CN103381193B - A kind of Rhodiola rosea micro powder tablet and preparation method thereof - Google Patents
A kind of Rhodiola rosea micro powder tablet and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of Rhodiola rosea micro powder tablet and preparation method thereof, solving existing tablet forming technique need add adjuvant, and the problem that the tablet effective ingredient prepared is lower.The present invention only adopts water content to be 3 ~ 15%, and particle diameter is the Radix Rhodiolae micropowder of 1 ~ 150 μm, and be-10 ~ 10 DEG C at pelletizing temperature and prepare the tablet obtained, preparation process does not add any adjuvant, and Radix Rhodiolae micropowder is the sole component of tablet.The object of direct compression molding can be realized by control moisture and temperature, or adopt the technique of circulation tabletting or dry granulation tabletting to realize.This technique makes flap-type outward appearance good, pitted skin rate and sliver rate low, tablet hardness, disintegration, friability meet tablet quality requirement, and this hardness can also ensure that the later stage carries out the process of coating, overlay film to this tablet, are unlikely to cracked in preparation process.
Description
Technical field
The invention belongs to medicine and field of health care food, be specifically related to a kind of Rhodiola rosea micro powder tablet and preparation method thereof.
Background technology
Under normal circumstances, be all first will require to select suitable adjuvant according to the character of medicine and clinical application when those skilled in the art prepare tablet, through hybrid process, make it have good mobility and compressibility.(pharmacy of Chinese materia medica, China Traditional Chinese Medicine Publishing House, in January, 2003 first edition, p411,2nd section reciprocal), during direct compression, the selection of adjuvant is extremely important, wherein the most important thing is filler and adhesive, and they are keys of tabletting.The effect in the film-making of wet grain method of acting on of the excipient in direct compression prescription, especially filler and adhesive even more important (pharmacy of Chinese materia medica, China Traditional Chinese Medicine Publishing House, in January, 2003 first edition, p410, the 4th section).
Radix Rhodiolae (Herba Rhodiolae) sacc. is that China's special product treasures Chinese crude drug, mainly originates in Tibet, northwestern Yunnan Province, western Sichuan.Be born in the patana of height above sea level 2800-5600 rice, shrubbery, in crack of stone.At present Radix Rhodiolae is made in the technique of tablet and generally all need used in combination with other medical material or add a large amount of adjuvants in order to figuration, Radix Rhodiolae never occurred with the form of pure medical material tablet, when tabletting, be no matter for Radix Rhodiolae powder or Radix Rhodiolae extraction process after extractum, extract powder etc., usually all can, by adding adjuvant to improve some performance of powder, extractum or extract powder, the tablet suppressed be made to meet correlated quality requirement.And press Biopharmaceutical Classification, wherein so-called full powder sheet is also suppress after adding suitable adjuvant to form usually, and non-fully uses Chinese drugs powder tabletting.As Chinese patent application (publication number CN97107821.1) Radix Rhodiolae buccal tablet, wherein disclose this tablet Radix Rhodiolae extractum 3-15 part about this patent document of granulating process, Mel 5-20 part, dextrin 20-40 part, Mentholum 1-5 part, xylitol 30-50 part, sucrose 40-60 part, magnesium stearate 0.8-1.2 part, citric acid 0.2-1 part, protein sugar 0.5-2 part, through mixing, solution processed, drying, sieves and makes tablet or block agent.As Chinese patent (CN1429622A) Radix rhodiolae double action lozenge, this buccal tablet of this patent disclosure is by Radix Rhodiolae extract (or superfine powder ground product) 5-30%, Cordyceps superfine powder 1.5%-18%, Radix Panacis Quinquefolii superfine powder 1.5%-18%, additive 40%-95%.So far, yet there are no the report preparing separately tablet with the pure medical material of Radix Rhodiolae.
In addition, when inventor finds that in research process Radix Rhodiolae is ground into the micropowder scaled powders of particle diameter 1-150 μm, its dissolution rate is very high, and can reach the blood drug level of disease therapy by active constituents of medicine at short notice.But the micropowder surface tension of particle diameter 1-150 μm is very large, between powder, space is large, and usual those skilled in the art are difficult to its direct compression or granulation, all needs to add adjuvant and improves its mobility, viscosity, compressibility so that tabletting.Conventional method is by fluid bed or wet method plasmid, but easily cause the volatile ingredient of Radix Rhodiolae or the loss of heat-sensitive ingredients in this method process, if moisture Control is not good in wet method plasmid, easily there is sticking, shedding, sliver, fall the technical problem of block, loose pieces, to overcome above-mentioned defect, usual need add adjuvant and carry out excipient, improve mobility of particle, water content to ensure tablet quality.But after with the addition of adjuvant, there will be mixing uneven, the defect that tablet medicine content is uneven.After with the addition of adjuvant, add invalid components simultaneously, reduce effective medicinal ingredient of Radix Rhodiolae buccal tablet.
In a word, having not yet to see only by Radix Rhodiolae micropowder, being pressed into the report of tablet when not adding any adjuvant.
Summary of the invention
The object of the present invention is to provide one only containing Radix Rhodiolae medical material micropowder, do not add the tablet of any adjuvant, can not reduce or destroy the effective ingredient of Radix Rhodiolae in preparation process, its appearance character and hardness meet tablet quality standard.
Realize technical scheme of the present invention as follows:
A kind of Rhodiola rosea micro powder tablet, it only adopts water content to be 3 ~ 15%, and particle diameter is that the Radix Rhodiolae powder of 1 μm ~ 150 μm suppresses the tablet obtained.
Further, described Radix Rhodiolae micropowder particle diameter is 5 ~ 45 μm.
Again further, the water content of described Radix Rhodiolae micropowder is 8%.
Further, during tabletting temperature at-10 ~ 10 DEG C; Preferred as one, pelletizing temperature is 5 DEG C.
Preferred as one, described tablet is buccal tablet.
The preparation method of above-mentioned Rhodiola rosea micro powder tablet, comprises the following steps:
(1) Radix Rhodiolae is crushed to the powder that particle diameter is 1 ~ 150 μm, controlling water content is 3 ~ 15%;
(2) Radix Rhodiolae micropowder direct pressing is in blocks, get product.
Further, the method for described direct compression is precompressed Radix Rhodiolae powder before tabletting, and wherein precompression is 0.5 ~ 1.5kN, and principal pressure is 5 ~ 10kN.Preferred as one, preload pressure is 1kN, and principal pressure is 8kN.
Above-mentioned preparation method, also comprising step (3) is after crossing 60 ~ 80 mesh sieves by the pulverizing of step (2) gained micropowder tablet, tabletting again.
In order to better realize the present invention, so repeatedly repeat step (3).
Further, again first use the pressure precompressed of 5 ~ 10kN before tabletting, then carry out main pressure, principal pressure is 5 ~ 10kN; Preferred as one, the preload pressure of tabletting is 8kN again, and principal pressure is 8kN.
The another kind of preparation method of above-mentioned Rhodiola rosea micro powder tablet, comprises the following steps:
(1) pulverized by Radix Rhodiolae as particle diameter is the micropowder of 1 ~ 150 μm, control water content is 3 ~ 15%;
(2) Radix Rhodiolae micropowder is pressed into large plate;
(3) large plate is crushed to can crosses after 80 ~ 100 mesh sieves tabletting again, get product.
Further, again first use the pressure precompressed of 5 ~ 10kN before tabletting, then carry out main pressure, principal pressure is 5 ~ 10kN; Preferred as one, the preload pressure of tabletting is 8kN again, and principal pressure is 8kN.
The present invention has the following advantages and beneficial effect:
(1) tablet of the present invention is not when adding any adjuvant, obtained flap-type outward appearance is good, pitted skin rate and sliver rate low, tablet hardness, disintegration, friability meet tablet quality requirement, and this hardness can also ensure that the later stage carries out the process of coating, overlay film to this tablet, be unlikely to cracked in preparation process; Meanwhile, tablet is because of nothing interpolation adjuvant, and user need not take the adjuvant without drug effect more, can ensure that Radix Rhodiolae high concentration is to give full play to the activity of medicine as much as possible.Radix Rhodiolae micropowder tabletting is low compared with the preparation cost of Radix Rhodiolae extract tabletting, but also when can prevent from extracting, effective ingredient runs off, and preparation technology is simpler.When Rhodiola rosea micro powder tablet of the present invention is applied with buccal tablet, by oral mucosa in conjunction with oral gastrointestinal absorption features, effective ingredient in Radix Rhodiolae micropowder is entered rapidly in body, improve curative effect, and dose can be made to reduce to reduce even at double, the meaning of its clinical meaning and the utilization of resources is very great.
(2) pelletizing temperature of the present invention controls at-10 ~ 10 DEG C, can effectively prevent pinch roller surface through extruding the extruding heat produced, prevent Radix Rhodiolae from cohering, stick wheel phenomenon, be more suitable for Radix Rhodiolae micropowder compressed tablets, mainly due to temperature lower than-10 DEG C time, in its production process, yield rate is only 15 ~ 17.2%, hardness is 1.11 ~ 1.21kg, pitted skin rate is up to 80 ~ 81%, and sliver rate, up to 71 ~ 76%, industrially cannot to be applied; When temperature is higher than 10 DEG C, in tableting processes, part Cordyceps powder end bonds, sticks wheel phenomenon, is unfavorable for the production of product and industrial operation; In addition, when temperature controls at 5 DEG C, compacting and the tablet yield rate that obtain is high, steady quality, conformance with standard, also reach product follow-up needed for the prescription such as product hardness, disintegration.
(3) by the control to pelletizing temperature, thus preload pressure and principal pressure value can be reduced, because when temperature is more than 10 DEG C, Cordyceps powder will bond, glutinous wheel phenomenon time, pinch roller surface just has material, and it is uneven that material subsequently just directly can not directly contact build-up of pressure with pinch roller surface, and two pinch roller gaps can be caused to become large simultaneously, thus necessary intensified pressure to the pressure of more than 10kN goes compacting, its tablet prepared of guarantee meets the requirements.And time in temperature range of the present invention, find that pressure is be more suitable for aweto micropowder compressed tablets at 5 ~ 10kN, reduce force value, thus decrease energy consumption, reduce production cost.
(4) by the control to above-mentioned pelletizing temperature and tableting pressure, find that moisture plays very important impact to product quality, if moisture lower than 3% time, there will be the situation such as sliver, spring sheet after tabletting, if moisture higher than 15% time, the variable color of tabletting time slice embryo, color burn, in dark-brown, tarnish reasons is that its effective ingredient is separated out, and causes the reduction of its active ingredients of cordyceps sinensis; And moisture is when being 3 ~ 15%, not only there will not be the situation such as sliver, spring sheet, also can not separate out effective ingredient, ensure that the active constituent content of tablet, the tablet yield rate of compacting is high, steady quality, conformance with standard simultaneously; In addition, when Radix Rhodiolae powder moisture is about 8%, the tablet yield rate of compacting is high, steady quality, conformance with standard, and this application industrially serves and acts on very easily.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is described in further detail, but embodiments of the present invention are not limited thereto.
In the present invention, under the pressing conditions of any adjuvant is not added in inventor creationary invention, when can not reduce in process or destroy rhodiola active ingredient, Radix Rhodiolae micropowder is pressed into efficient pure powder sheet truly, has improved the bioavailability of Radix Rhodiolae.
Rhodiola rosea micro powder tablet of the present invention, it adopts water content to be 3-15%, particle diameter is 1-150 μm, Radix Rhodiolae micropowder temperature when tabletting be the-10-10 DEG C of tablet preparing to obtain by dry method plasmid tabletting, simultaneously do not reduce in preparation process or destroy Radix Rhodiolae bioactive ingredients.Do not add any adjuvant in preparation process, Radix Rhodiolae is the sole component of tablet.
Particle diameter is selected to be the Radix Rhodiolae powder of 1-150 μm in the present invention, because the powder grinding particle size of this particle size range is evenly distributed, parameter declaration according to grain size analysis report reaches Cellular Level Pulverizing, and result of study shows that total leachable of the inventive method is relevant with the grinding particle size of Radix Rhodiolae with the dissolution of rhodioside, grinding particle size is less, dissolution time is shorter, and namely dissolution is larger.
The active substance dissolution test pulverizing rank below by way of Radix Rhodiolae difference illustrates the foundation that micropowder is selected.Pulverizing rank is No. I powder D90=150-500 μm, No. II powder D90=25-45 μm, No. III powder D90=10-20 μm.Effective ingredient stripping table 1 in time in the Radix Rhodiolae of different pulverizing rank.
1, the mensuration of total leachable
Precision takes Radix Rhodiolae decoction pieces, Radix Rhodiolae No. I powder, No. II powder, No. III powder, add 37 DEG C of pure water 100ml, after stirring, be placed in 37 DEG C ± 1 water-bath, respectively 3,10,20,30,45,60min sampling, centrifugal (3500 revs/min) 1 minute, get supernatant 50ml, put in the evaporating dish of constant weight, 105 DEG C of dryings 3 hours, calculate total leachable amount.
Table 1 difference pulverizes total leachable dissolution in time (%) in the Radix Rhodiolae of rank
| Time (min) | 3 | 10 | 20 | 30 | 45 | 60 |
| Radix Rhodiolae decoction pieces | 1.73 | 3.83 | 8.03 | 9.06 | 9.12 | 9.27 |
| Radix Rhodiolae No. I powder | 11.65 | 12.43 | 12.94 | 13.10 | 13.62 | 13.91 |
| Radix Rhodiolae No. II powder | 33.84 | 34.15 | 34.90 | 36.40 | 37.20 | 37.39 |
| Radix Rhodiolae No. III powder | 33.86 | 34.25 | 34.94 | 36.49 | 37.20 | 37.39 |
In table 1, the different measurement result pulverizing the total leachable of Radix Rhodiolae of rank shows, each dissolution pulverizing rank increases progressively in time.Radix Rhodiolae No. II powder, No. III powder all than Radix Rhodiolae decoction pieces and No. I powder stripping rapid, and remain higher dissolution.Particularly when 3min, Radix Rhodiolae No. II powder (33.84%), No. III powder (33.86%) higher than nearly 30 times of Radix Rhodiolae decoction pieces (1.73%), higher than (11.65%) 3 times, No. I powder.When 60min, Radix Rhodiolae No. II powder (37.29%) and No. III powder (37.29%), also higher than Radix Rhodiolae decoction pieces (9.27%) 4 times, exceed (13.91%) 2 times, No. I powder.Radix Rhodiolae No. II powder and No. III powder there is no too big-difference on dissolution, reach the same when 60min.
2, the mensuration of rhodioside
(1) chromatographic condition: with reference to content assaying method under Chinese Pharmacopoeia Radix Rhodiolae medical material item.
Chromatographic column: TIANHE Kromail C18250 × 4.6mm5 μm;
Mobile phase: methanol-water (15:85);
Determined wavelength: 275nm;
Flow velocity: 1ml/min;
Column temperature: 30 DEG C.
(2) reference substance solution preparation: precision takes gets rhodioside reference substance 5.97mg, is placed in 10ml measuring bottle, adds methanol dilution to scale, then precision measures 3ml and is placed in 10ml measuring bottle, is diluted with water to scale, shakes up, to obtain final product.
(3) need testing solution preparation:
Precision takes Radix Rhodiolae decoction pieces, Radix Rhodiolae No. I powder, No. II powder, No. III powder, and be placed in tool plug conical flask, precision adds methanol 10ml, close plug, weighed weight, supersound process 30 minutes, let cool, more weighed weight, the weight of less loss is supplied with methanol, shake up, filter, get subsequent filtrate 3ml and be placed in 10ml measuring bottle, be diluted with water to scale, shake up, filter with 0.45 μm of microporous filter membrane, get filtrate, to obtain final product.
(4) algoscopy:
Get reference substance solution and each 10 μ l of need testing solution respectively, injection liquid chromatography, record peak area, calculates, to obtain final product.Wherein, rhodioside reference substance concentration: 0.1791mg/ml, rhodioside reference substance peak area: 501.4 and 502.6 is average: 502.0.
Table 2 difference pulverizes rhodioside dissolution in time (%) in the Radix Rhodiolae of rank
| Time (min) | 3 | 10 | 20 | 30 | 45 | 60 |
| Radix Rhodiolae decoction pieces | 0.06 | 0.08 | 0.18 | 0.29 | 0.33 | 0.56 |
| Radix Rhodiolae No. I powder | 0.42 | 0.53 | 0.68 | 0.80 | 0.93 | 1.04 |
| Radix Rhodiolae No. II powder | 1.70 | 1.74 | 1.75 | 1.76 | 1.80 | 1.85 |
| Radix Rhodiolae No. III powder | 1.72 | 1.75 | 1.76 | 1.78 | 1.80 | 1.85 |
In table 2, in the Radix Rhodiolae of different pulverizing rank, rhodioside dissolution determination result in time shows, each dissolution pulverizing the rhodioside of rank increases progressively in time.Radix Rhodiolae No. II powder, No. III powder all than Radix Rhodiolae decoction pieces and No. I powder stripping rapid, and remain higher dissolution.Particularly when 3min, Radix Rhodiolae No. II powder (1.70%), No. III powder (1.72%) higher than nearly 28 times of Radix Rhodiolae decoction pieces (0.06%), higher than (11.65%) 3 times, No. I powder.When 60min, Radix Rhodiolae No. II powder (1.85%) and No. III powder (1.85%), also higher than nearly 4 times of Radix Rhodiolae decoction pieces, exceed nearly 2 times of No. I powder.Radix Rhodiolae No. II powder and No. III powder there is no too big-difference on dissolution, reach the same when 60min.
Table 1,2 explanations, when the particle diameter of Radix Rhodiolae is 1-150 μm, show in the comparison of test results of instantaneous (3min) dissolution, Radix Rhodiolae No. II powder and No. III its effective ingredient of powder energy rapid, high volume stripping, and the now not a large amount of stripping of the effective ingredient of Radix Rhodiolae decoction pieces and No. I powder.At 60min, Radix Rhodiolae No. II powder and No. III powder can remain higher dissolution, all be much higher than the dissolution of other groups, this is because micropowder has extremely strong stripping penetrating power, the dissolution of Radix Rhodiolae No. II powder and No. III powder is very close simultaneously, this illustrates after powder arrives 45 μm, and its dissolution is just very rapid.Therefore micropowder tablet of the present invention namely can be conventional oral, also can oral cavity buccal, by oral mucosal absorption active ingredient, rhodiola active ingredient is made to discharge and enter in human body rapidly in limited digestion time, thus raising curative effect, and dose can be made to reduce to reduce even at double, the meaning of its clinical meaning and the utilization of resources is very great.
In addition, present inventor is in the research process of tablet forming technique, first find that pelletizing temperature is extremely important to control product quality, should control-10 ~ 10 DEG C time, can effectively prevent pinch roller surface through extruding the extruding heat produced, prevent Radix Rhodiolae from cohering, stick wheel phenomenon, be more suitable for Radix Rhodiolae micropowder compressed tablets.When pelletizing temperature is lower than-10 DEG C, its finished product rate is only 15 ~ 17.2%, and hardness is 1.11 ~ 1.21kg, and pitted skin rate is up to 80 ~ 81%, and sliver rate, up to 71 ~ 76%, industrially cannot to be applied.When tabletting, temperature is higher than 10 DEG C, and during tabletting, part Radix Rhodiolae powder bonds, sticks wheel phenomenon, is unfavorable for the production of product and industrial operation, therefore selects pelletizing temperature to be-10 ~ 10 DEG C, can realize the object of micropowder tabletting.According to Radix Rhodiolae micropowder in pressing process temperature on the experiment of the impact of tablet quality in draw, when tabletting, temperature is 5 DEG C time, compacting and the tablet yield rate that obtains is high, steady quality, conformance with standard, also reaches the follow-up required prescription such as product hardness, disintegration of product.
Simultaneously, moisture is also very important affecting parameters to product quality, and during tabletting, temperature is when temperature controls at-10 ~ 10 DEG C, and inventor is in the screening process of tablet forming technique, find that moisture is 3 ~ 15% time, is more suitable for winter Radix Rhodiolae micropowder compressed tablets.If moisture lower than 3% time, there will be the situation such as sliver, disintegrating tablet after tabletting, if moisture higher than 15% time, tabletting time slice embryo with variable color, color burn, in rufous, tarnish reasons be its effective ingredient separate out, cause the reduction of its rhodiola active ingredient.Inventor draws in Radix Rhodiolae powder moisture is on the experiment of the impact of tablet quality, and when Radix Rhodiolae powder moisture is about 8%, the tablet yield rate of compacting is high, steady quality, conformance with standard, and this application industrially serves and acts on very easily.
The present inventor is realized by following preparation technology, and does not all add any adjuvant in order to figuration:
One, direct pressed powder technique, obtains Radix Rhodiolae micropowder direct compression.
Two, circulation tablet forming technique: after Radix Rhodiolae micropowder direct compression, then be by after 60 ~ 80 mesh sieves by the pulverizing of this micropowder tablet; If do not reach tablet requirement, repeat to appeal step, until qualified.
Three, dry granulation tablet forming technique: Radix Rhodiolae micropowder is pressed into large plate, then be crushed into and can cross after 60 ~ 80 mesh sieves, at tabletting and get final product.
In the screening of technique, adopt the method compacting of precompression and principal pressure, its pressure is different because of the difference of technique, according to direct pressed powder technique, wherein preload pressure is 0.5 ~ 1.5KN, and principal pressure is 5 ~ 10kN, preferred preload pressure is 1kN, and principal pressure is 8kN.According to repeatedly tablet forming technique or dry method plasmid technique, wherein preload pressure 5 ~ 10kN, principal pressure is 5 ~ 10kN, preferred preload pressure 8kN, principal pressure 8kN.
Finding in tabletting test, still there is difference in three kinds of techniques in the present invention qualitatively.Wherein direct pressed powder technique, yield rate is low, the tablet of preparation easily occur discrete piece, shedding, fall block, sliver, loose pieces etc. problem.And repeatedly tablet forming technique and dry method plasmid technique all can obtain good effect, prepared tablet meets the requirements.
Below the confirmation tablet forming technique screening test data that inventor records.
Be below the confirmation tablet forming technique screening test data that inventor records, product quality is in table 3 ~ 5.
Table 3 technique of direct powder compression
Table 4 circulates tablet forming technique
Table 5 dry granulation process
Embodiment 1 micropowder direct compression technique
1, raw material: Radix Rhodiolae micropowder, particle diameter D90=25-45 μm, moisture about 8%.
2, tablet machine revolution 15/h, preload pressure 8kN, principal pressure 8kN.
3, pelletizing temperature is set to 5 DEG C.
4, ambient temperature 22 DEG C, ambient humidity 48%.
According to above-mentioned technique compressed tablets, tablet format 0.25g/ sheet, 100.
Embodiment 2 circulates tablet forming technique
1, raw material: Radix Rhodiolae micropowder, particle diameter D90=25-45 μm, moisture gets over 8%.
2, tablet machine revolution 15/h, preload pressure 8kN, principal pressure 8kN.
3, pelletizing temperature is set to 5 DEG C.
4, ambient temperature 22 DEG C, ambient humidity 48%.
During according to above-mentioned technique compressed tablets, first by powder compaction sheet, then pulverized 60-80 mesh sieve, tabletting again, if do not reach requirement, appeal step tabletting can be repeated, until tablet quality is qualified, tablet format 0.25g/ sheet, 100.
Embodiment 3 circulates tablet forming technique
1, raw material: Radix Rhodiolae micropowder, particle diameter D90=25-45 μm, moisture gets over 8%.
2, tablet machine revolution 15/h, preload pressure 8kN, principal pressure 8kN.
3, pelletizing temperature is set to 5 DEG C.
4, ambient temperature 22 DEG C, ambient humidity 48%.
According to above-mentioned technique compressed tablets, first by large for powder compaction plate, then pulverized 60-80 mesh sieve, tabletting again, tablet format 0.25g/ sheet, 100.
By three kinds of technique compactings by Radix Rhodiolae tabletted, gained tablet carries out quality comparation, see table 6.
Table 6 three kinds of process results contrast tables (in 100 tablets of micropowder tablets)
By comparing in above-mentioned table 6, apply above-mentioned three kinds of techniques and all can prepare the pure powder sheet of the Radix Rhodiolae conformed to quality requirements, but gone out by Comparative result, circulation tablet forming technique and dry granulation tablet forming technique can all meet tablet quality requirement in hardness, disintegration, emerald green broken degree aspect again, both are without significant difference, also can reach necessary requirement in appearance, and obviously be less than technique of direct powder compression.
To sum up telling, it is simple that the present invention prepares tablet technology, and site technique workflow reengineering is convenient, and feasibility is strong, applied range.
According to above-described embodiment, just the present invention can be realized well.What deserves to be explained is; under prerequisite based on above-mentioned design, for solving same technical problem, even if some making on the invention are without substantial change or polishing; the essence of the technical scheme adopted is still the same with the present invention, therefore it also should in protection scope of the present invention.
Claims (4)
1. a Rhodiola rosea micro powder tablet, is characterized in that, it only adopts water content to be 8%, and particle diameter is that the Radix Rhodiolae powder of 25 μm ~ 45 μm suppresses the tablet obtained; Described tablet is buccal tablet.
2. the preparation method of a kind of Rhodiola rosea micro powder tablet according to claim 1, is characterized in that, comprise the following steps:
(1) Radix Rhodiolae is crushed to the powder that particle diameter is 25 ~ 45 μm, controlling water content is 8%;
(2) Radix Rhodiolae micropowder direct pressing is in blocks, get product;
Wherein, the method for described direct compression is precompressed Radix Rhodiolae powder before tabletting, and wherein precompression is 1kN, and principal pressure is 8kN; Again first use the pressure precompressed of 8kN before tabletting, then carry out main pressure, principal pressure is 8kN, and in tableting processes, temperature is-10 ~ 10 DEG C.
3. the preparation method of a kind of Rhodiola rosea micro powder tablet according to claim 2, is characterized in that, also comprising step (3) is after crossing 60 ~ 80 mesh sieves by the pulverizing of step (2) gained micropowder tablet, tabletting again.
4. the preparation method of a kind of Rhodiola rosea micro powder tablet according to claim 1, is characterized in that, comprise the following steps:
(1) pulverized by Radix Rhodiolae as particle diameter is the micropowder of 25 ~ 45 μm, control water content is 8%;
(2) Radix Rhodiolae micropowder is pressed into large plate;
(3) large plate is crushed to can crosses after 80 ~ 100 mesh sieves tabletting again, get product;
Wherein, again first use the pressure precompressed of 8kN before tabletting, then carry out main pressure, principal pressure is 8kN; In addition, in tableting processes, temperature is-10 ~ 10 DEG C.
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| CN110559186A (en) * | 2018-12-25 | 2019-12-13 | 安徽群康药业科技有限公司 | Production process for preparing traditional Chinese medicine decoction pieces |
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| CN115399474B (en) * | 2022-08-29 | 2024-03-26 | 广西壮族自治区农业科学院 | Processing method of selenium-enriched moringa oleifera leaf raw powder tablet |
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