CN101983684B - Drug for treating gastrosis and preparation method thereof - Google Patents
Drug for treating gastrosis and preparation method thereof Download PDFInfo
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- CN101983684B CN101983684B CN2010102637340A CN201010263734A CN101983684B CN 101983684 B CN101983684 B CN 101983684B CN 2010102637340 A CN2010102637340 A CN 2010102637340A CN 201010263734 A CN201010263734 A CN 201010263734A CN 101983684 B CN101983684 B CN 101983684B
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Abstract
The invention discloses a drug for treating gastrosis, which is characterized by being mainly prepared from the following raw materials by weight: 1-20 parts of roses, 1-20 parts of seville orange flowers, 1-20 parts of cuttlefish bone powder, 1-20 parts of fritillary powder, 1-20 parts of liquorice, 1-20 parts of mandragora and 1-20 parts of edible alcohol with content being more than 95%. The drug can be absorbed by the spleens and stomachs internally or absorbed by skins externally or absorbed internally and externally. The drug has reasonable components, simple compatibility and confirmed curative effect, can treat both principal and secondary aspects of the diseases and can be used for treating hyperchlorhydria, epigastric pain, digestive tract ulcer and other diseases. The invention also provides a preparation method of the drug.
Description
Technical field
The invention belongs to the field of Chinese medicines, medicine of the treatment gastropathy of particularly a kind of oral administration or external and preparation method thereof.
Background technology
Gastropathy is actually the general designation of many diseases.Common clinically gastropathy has the innocent and malignant tumour of acute gastritis, chronic gastritis, gastric ulcer, duodenal ulcer, gastroduodenal complex ulcer, polyp of stomach, gastric calculus, stomach, also has prolapse of gastric mucosa, acute gastric dilatation, pyloric obstruction etc.They have similar symptom, as upper abdomen gastral cavilty portion discomfort, pain, after meal glutted, belch, return acid, even feel sick, vomiting or the like.Modern society's daily life hectic, cause people can not be on time diet according to quantity, cause that easily stomachache, stomach are uncomfortable.
Chinese patent CN200710023841.4 discloses a kind of herb liquid of treating gastropathy; It is that Fructus Foeniculi, the Radix Linderae, Radix osterici citriodori (Radix Angelicae Citriodorae), Radix Viticis Cannabifoliae, Fructus Linderae Glaucae, Radix Sophorae Flavescentis, Herba Siphonostegiae, Herba Plantaginis, Herba Andrographis, root of Rhizoma Pinelliae Cordatae, the Rhizoma Pinelliae, Rhizoma Cyperi, Alpinia japonica (Thunb.) Miq., root of BAIMIANFENG are removed the chopping of impurity afterwash; Putting together adds suitable quantity of water immersion 24～30 hours, it is boiled after 20～30 minutes after-filtration of 100 ℃ of continued decoctions go out medicinal liquid promptly to make medicinal liquid again.One Chinese patent application CN200910185471.3 discloses a kind of Chinese medicine of treating gastropathy, and raw material components is: Herba Taraxaci, Bulbus Lilii, Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, Os Sepiae, the Radix Linderae, Fructus Amomi, Rhizoma Alpiniae Officinarum, Rhizoma Cyperi, Pollen Tyjphae (parched), Rhizoma Corydalis (parched with vinegar), Fructus Toosendan, Olibanum (processed), Myrrha (processed), Lignum Dalbergiae Odoriferae, Oletum Trogopterori, the Pseudobulbus Bletillae (Rhizoma Bletillae).
More than the Chinese medicine product of treatment gastropathy is too much paid attention to regulating, and used taste of Chinese medicine number is too much, has reduced the medicine proportion of a therapeutical effect relatively, has influenced the pharmic function performance, so effect is slow, the course of treatment is long, and effect is undesirable; And existing Chinese medicine oral administration but can not external, but can not the taking orally again of external, route of administration is single, makes the patient slow to the absorption of medicine.Chinese medicine for oral administration not only absorbs slowly, and causes spleen injury easily, even increase the weight of the state of an illness for the patient of weakness of the spleen and stomach.
Chinese medicine is taken difficulty owing to the decoction or the pill that are mostly to boil than Western medicine, has also influenced the popularization of Chinese medicine widely.
Summary of the invention
The objective of the invention is to overcome the defective that prior art exists; A kind of reasonable recipe is provided; Compatibility is simplified, the medicine of the treatment gastropathy of determined curative effect, treating both the principal and secondary aspects of a disease, is main to control, and controls to support to combine; And this medicine can take orally through taste absorb again can external through skin absorbs, can also oral administration and externally used dual mode composite absorbent.This compound administering mode helps the efficient absorption of human body to medicine, and for the crowd of weakness of the spleen and stomach, the medicine that is busy with one's work, spares oneself provides multiple choices, especially the patient by the modern job crowd is accepted.
Technical scheme of the present invention is following:
A kind of medicine of treating gastropathy is characterized in that it mainly is to be processed by the raw material of following weight portion: 1 ~ 20 part of Flos Rosae Rugosae, 1 ~ 20 part of CitrusaurantiumL.Var.amara Engl.; 1 ~ 20 part of cuttlefish bone meal, 1 ~ 20 part in Bulbus Fritillariae Uninbracteatae powder, 1 ~ 20 part in Radix Glycyrrhizae; 1 ~ 20 part of Flos Daturae, content are 1 ~ 20 part of edible ethanol more than 95%.
Further, the consumption of each component of medicine of the present invention is: 15 ~ 20 parts of Flos Rosae Rugosaes, and 15 ~ 20 parts of CitrusaurantiumL.Var.amara Engl.s, 15 ~ 20 parts of cuttlefish bone meals, 15 ~ 20 parts in Bulbus Fritillariae Uninbracteatae powder, 5 ~ 10 parts in Radix Glycyrrhizae, 1 ~ 5 part of Flos Daturae, content is 15 ~ 20 parts of edible ethanols more than 95%.
The middle survival dose of above compatibility is the crude drug amount.
In order to strengthen the transdermal effect of medicine, can also mix transdermal agent in the medicine of the present invention, preferably weight portion is 1 ~ 5 part a azone.
Another object of the present invention provides manufacturing method for above mentioned medicine, it is characterized in that comprising the following steps:
A) take by weighing Flos Rosae Rugosae, CitrusaurantiumL.Var.amara Engl., cuttlefish bone meal, Bulbus Fritillariae Uninbracteatae powder, Radix Glycyrrhizae and the Flos Daturae of said weight proportion, according to the conventional method for distilling of Chinese medicine, the extract of the former medicine that obtains respectively respectively to distinguish the flavor of;
B) under the room temperature, get the deionized water of 5 ~ 6 times of amounts, the content that adds said weight proportion is the edible ethanol more than 95%, is mixed with aqueous solution of alcohol;
C) with in the above-mentioned aqueous solution of alcohol of the extract obtained adding of step a, stirred 120 minutes, precipitate 2 ~ 4 hours, filter, gained filtrating sterilization, fill according to quantity must be treated the medicine of gastropathy.
Further, among the step c, can add in the aqueous solution of alcohol together by azone step a is extract obtained and 1 ~ 5 weight portion.
The conventional method for distilling of said Chinese crude drug can adopt decocting method, circumfluence method, infusion process, percolation, semi-bionic extraction, supercritical fluid extraction, microwave extraction method etc. according to the kind of medical material.
The present invention is directed to the characteristics of gastropathy, select Flos Rosae Rugosae, CitrusaurantiumL.Var.amara Engl., cuttlefish bone meal, Bulbus Fritillariae Uninbracteatae powder, Radix Glycyrrhizae, Flos Daturae for use,, process to contain pure Chinese medicine extraction liquid being that edible ethanol more than 95% mixes with content after each flavor Chinese medicine extraction.Employing is main to control, and control the bonded method of supporting, but not only also external of oral administration of the medicine of processing is a kind of reasonable recipe, and compatibility is simplified, the medicine of the treatment gastropathy of determined curative effect, treating both the principal and secondary aspects of a disease.
The same usefulness of Os Sepiae and Bulbus Fritillariae Thunbergii, name is said Medicinal powder of cuttlefish and firtillary bulb, experiment showed, adsorb significantly pepsin with in the effect of gastric acid, thereby can protect ulcer surface; Radix Glycyrrhizae and middle relieving spasm to stop pain, invigorating the spleen and replenishing QI; Flos Daturae has analgesic activity preferably.The present invention is main with Medicinal powder of cuttlefish and firtillary bulb, adds Radix Glycyrrhizae and Flos Daturae, has strengthened analgesic effect, and Radix Glycyrrhizae can separate the poison of Flos Daturae, should grow clothes.Clothes before the food, food is still few in the stomach, helps pharmaceutically-active performance.
Flos Rosae Rugosae regulate the flow of vital energy resolving depression and blood dissipating blood stasis; The CitrusaurantiumL.Var.amara Engl. the chest stuffiness relieving of regulating the flow of vital energy, dispersing the stagnated liver-QI for regulating the stomach, appetizing preventing or arresting vomiting.Two medicines, 5 usefulness, a gas one blood, QI and blood is two to be transferred, and the strength of eliminating turbid pathogen with aromatics, be amusing appetizing, regulating QI to relieve pain strengthens.Content is the edible ethanol blood circulation promoting and blood stasis dispelling more than 95%, promotes that drug osmotic to cell absorbs.
Medicine of the present invention can be smeared abdominal part with medicine of the present invention except for oral administration, and the efficacy of a drug sick institute that goes directly so can remove the patient suffering, obtains and imitates in no time.This medicine is applicable to that also whole body smears.Adopt oral administration and externally usedly, drug effect is more remarkable.
It is obvious that the present invention treats the gastropathy curative effect, and short treating period can be used for treating diseases such as hyperchlorhydria, gastralgia, digestive tract ulcer.Clinical usefulness repeatly, analgesic effect are very prompt.That tests is clinical, truly has the good of " medicine ends to pain " to imitate.
Medicine of the present invention is through clinical 70 routine patients' clinical verification, and curing number is 49 examples, and significant figure is 16 examples, and invalid number is 5 examples, and total effective rate reaches 92.8%.Do not see toxic side effect in the therapeutic process, the patient has better curative effect to obstinate.
For further specifying therapeutic effect, to enumerate model case following at present:
Case 1: certain man, 30 years old, suffer from the gastropathy several years, stomachache often, gastric acid, flatulence.Adopt the western medical treatment DeGrain, be prone to repeatedly.Oral medicine of the present invention, each 10 milliliters, every day 3 times, above disease was alleviated in 3 days, eliminated in 18 days.Paying a return visit after 6 months does not have recurrence.
Case 2: certain woman, 24 years old, often the stomachache, gastric acid.External medicine of the present invention is smeared whole body and abdominal part, and every day 2 times, each 10 milliliters, above disease was alleviated in 2 days, eliminated in 16 days.Paying a return visit after 8 months does not have recurrence.
Case 3: certain man, 40 years old, suffer from gastropathy for many years, stomachache often, gastric acid, flatulence.Once took the Chinese medicine of a variety of treatment gastropathy, but effect is all not good.External medicine of the present invention is smeared whole body and abdominal part, and every day 2 times, each 10 milliliters, above disease was alleviated in 2 days, and symptom was eliminated in 12 days.Paying a return visit after 9 months does not have recurrence.
The specific embodiment
Embodiment 1
Take by weighing 15 parts of Flos Rosae Rugosaes, 18 parts of CitrusaurantiumL.Var.amara Engl.s, 16 parts of cuttlefish bone meals, 16 parts in Bulbus Fritillariae Uninbracteatae powder, 6 parts in Radix Glycyrrhizae, 1 part of Flos Daturae adopts the method that decocts the back concentrating under reduced pressure to process Chinese medicine extract respectively, and is subsequent use.
Under the room temperature, get the deionized water of 5 ~ 6 times of amounts, add content and be 18 parts of 96% edible ethanols, be mixed with aqueous solution of alcohol, subsequent use.
Above-mentioned various Chinese medicine extract are added in the aqueous solution of alcohol, fully stirred 120 minutes, precipitate 2 ~ 4 hours, supernatant 200 orders filter, and the medicine that gained filtrating is the treatment gastropathy of oral administration or external carries out fill under aseptic condition.Gained precipitate and filtering residue focus on.
Embodiment 2
The drug component proportioning is: 18 parts of Flos Rosae Rugosaes, and 19 parts of CitrusaurantiumL.Var.amara Engl.s, 17 parts of cuttlefish bone meals, 17 parts in Bulbus Fritillariae Uninbracteatae powder, 6 parts in Radix Glycyrrhizae, 1 part of Flos Daturae, content is 18 parts of 97% edible ethanols.Other is identical with embodiment 1.
Embodiment 3
The drug component proportioning is: 19 parts of Flos Rosae Rugosaes, and 20 parts of CitrusaurantiumL.Var.amara Engl.s, 19 parts of cuttlefish bone meals, 18 parts in Bulbus Fritillariae Uninbracteatae powder, 6 parts in Radix Glycyrrhizae, 1 part of Flos Daturae, content is 18 parts of 98% edible ethanols.Other is identical with embodiment 1.
Embodiment 4
The drug component proportioning is: 15 parts of Flos Rosae Rugosaes, and 16 parts of CitrusaurantiumL.Var.amara Engl.s, 18 parts of cuttlefish bone meals, 20 parts in Bulbus Fritillariae Uninbracteatae powder, 8 parts in Radix Glycyrrhizae, 2 parts of Flos Daturaes, content is 16 parts of 99% edible ethanols.Other is identical with embodiment 1.
Embodiment 5
The drug component proportioning is: 20 parts of Flos Rosae Rugosaes, and 19 parts of CitrusaurantiumL.Var.amara Engl.s, 16 parts of cuttlefish bone meals, 18 parts in Bulbus Fritillariae Uninbracteatae powder, 10 parts in Radix Glycyrrhizae, 3 parts of Flos Daturaes, content is 20 parts of 100% edible ethanols.Other is identical with embodiment 1.
Embodiment 6
The drug component proportioning is: 18 parts of Flos Rosae Rugosaes, and 18 parts of CitrusaurantiumL.Var.amara Engl.s, 20 parts of cuttlefish bone meals, 20 parts in Bulbus Fritillariae Uninbracteatae powder, 8 parts in Radix Glycyrrhizae, 2 parts of Flos Daturaes, content is 20 parts of 97% edible ethanols.Other is identical with embodiment 1.
Claims (1)
1. medicine of treating gastropathy is characterized in that being processed by following method:
(1) take by weighing 15 parts of Flos Rosae Rugosaes, 18 parts of CitrusaurantiumL.Var.amara Engl.s, 16 parts of cuttlefish bone meals, 16 parts in Bulbus Fritillariae Uninbracteatae powder, 6 parts in Radix Glycyrrhizae, 1 part of Flos Daturae adopts the method that decocts the back concentrating under reduced pressure to process Chinese medicine extract respectively, and is subsequent use;
(2) under the room temperature, get the deionized water of 5 ~ 6 times of amounts, add content and be 18 parts of 96% edible ethanols, be mixed with aqueous solution of alcohol, subsequent use;
(3) above-mentioned various Chinese medicine extract are added in the aqueous solution of alcohol, fully stirred 120 minutes, precipitate 2 ~ 4 hours, supernatant 200 orders filter, and the medicine that gained filtrating is the treatment gastropathy of for oral administration or external carries out fill under aseptic condition.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010102637340A CN101983684B (en) | 2010-08-26 | 2010-08-26 | Drug for treating gastrosis and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010102637340A CN101983684B (en) | 2010-08-26 | 2010-08-26 | Drug for treating gastrosis and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101983684A CN101983684A (en) | 2011-03-09 |
| CN101983684B true CN101983684B (en) | 2012-07-04 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2010102637340A Expired - Fee Related CN101983684B (en) | 2010-08-26 | 2010-08-26 | Drug for treating gastrosis and preparation method thereof |
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| Country | Link |
|---|---|
| CN (1) | CN101983684B (en) |
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- 2010-08-26 CN CN2010102637340A patent/CN101983684B/en not_active Expired - Fee Related
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| CN101983684A (en) | 2011-03-09 |
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Granted publication date: 20120704 Termination date: 20180826 |