CN105999383A - Anti-inflammatory sterilizing adhesive for soft tissue - Google Patents
Anti-inflammatory sterilizing adhesive for soft tissue Download PDFInfo
- Publication number
- CN105999383A CN105999383A CN201610398184.0A CN201610398184A CN105999383A CN 105999383 A CN105999383 A CN 105999383A CN 201610398184 A CN201610398184 A CN 201610398184A CN 105999383 A CN105999383 A CN 105999383A
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- soft tissue
- antiinflammatory
- powder
- inflammatory
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/046—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
- A61L24/0015—Medicaments; Biocides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/08—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/10—Polypeptides; Proteins
- A61L24/102—Collagen
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L89/00—Compositions of proteins; Compositions of derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/216—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with other specific functional groups, e.g. aldehydes, ketones, phenols, quaternary phosphonium groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/41—Anti-inflammatory agents, e.g. NSAIDs
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- Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Surgery (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Materials For Medical Uses (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses an anti-inflammatory sterilizing adhesive for soft tissue. The adhesive comprises, by weight, 70 to 80 parts of polyether-ether-ketone, 12 to 17 parts of jellyfish collagen, 5 to 11 parts of chitin, 3 to 8 parts of metronidazole, 4 to 7 parts of citrate, 2 to 8 parts of glycol, 12 to 20 parts of chitosan lactate, 5 to 8 parts of Chinese honey locust powder, 7 to 11 parts of common peony root powder, 3 to 8 parts of tricalcium phosphate, 5 to 8 parts of dexpanthenol, 5 to 10 parts of tea polyphenol and 5 to 10 parts of carboxymethylcellulose sodium. The anti-inflammatory sterilizing adhesive for soft tissue has high bonding strength and compressive strength, is slightly irritant to the tissue of living bodies and free of any harmful reagent, exerts anti-inflammatory and sterilizing effect and is applicable to surgical operation, especially to bonding of soft tissue.
Description
Technical field
The invention belongs to biomedical materials field, be specifically related to one and there is antiinflammatory biocidal efficacies
Soft tissue binding agent.
Background technology
Biomaterial is for tissue and the diagnosis of organ, repairs or promote the one of its function
Class High-tech Material, is i.e. used for replacing, repairing living tissue natural or artificial material, its effect
Medicine is irreplaceable.Biomaterial can perform, promote or replace because disease, damage etc. lose
Certain function, and rejected region can not be recovered.Since the later stage nineties, world's biology material
Material Science and Technology develops rapidly, even if under the overall situation that current global economy is low, biological
Material still remains annual 13% rapid growth, has fully demonstrated its powerful vitality with wide
Wealthy development prospect.The regeneration of modern medicine forward and rebuild impaired tissue and organ,
Recover and promote the directions such as human body physiological function, personalization and minimally-invasive treatment to develop.Traditional nothing
The conventional materials such as the medical metal of life, macromolecule, bioceramic can not meet medical development
Requirement, biomedical material scientific and engineering is faced with new opportunities and challenges.Future, raw
Medicine may well will be caught up with in the market share of thing medical material.Therefore, bio-medical is strengthened
The clinical application research of material and popularization and application, give priority to grinding of China's bio-medical material
Study carefully, develop, produce, the integrated system combined closely of marketing is the task of top priority.It practice,
Country currently has been achieved for important breakthrough progress in terms of biomaterial scientific basic research, walks
In world's rank of advanced units, but industrialization level waits to improve, and industry size is little, development is relative
Delayed, it is not met by being actually needed of Medicare health care.In national policy, economic big
Under power is supported, the industrialized development of China's biomaterial will speed-raising.Enterprise should strengthen autonomous innovation
Ability, solve further to rely on the situation of import, add large outlet dynamics, it is achieved cross over simultaneously
Development, expands Chinese biological material product power of influence in the world.
Biomaterial is widely used, and kind is a lot, and its sorting technique is the most a lot.Biomaterial bag
Include metal material (such as alkali metal and alloy thereof etc.), inorganic material (bioactive ceramics, hydroxyl
Base apatite etc.) and organic material three major types.Organic material is mainly polymeric set compound material
Material, macromolecular material generally by material properties be divided into synthesis macromolecular material (polyurethane, polyester,
Polylactic acid, polyglycolic acid, PLGA and other medical synthetic plastic and rubber
Deng), natural macromolecular material (such as collagen, fibroin, cellulose, chitosan etc.)；According to
The purposes of material, these materials can be divided into again biologically inert (bioinert), biological activity
Or biodegradation (biodegradable) material, high molecular polymer (bioactive)
In, can be by organism metabolism and absorption according to catabolite, degradation-type macromolecule can be divided into again life
Thing absorbability and biological nonabsorable.According to after material and contacting blood to blood constituent,
The state that affects of performance is then divided into blood compatible polymer and blood incompatibility.According to material
To the affinity of body cell with report situations, biocompatibility and bio-incompatibility can be divided into
Polymer etc..
Adhesive of medical just belongs to the one in biodegradation material, and adhesive of medical is mainly used in
The various operations of surgery such as various traumatic wounds, cosmetic surgery, family planning, it is to human-body biological
Tissue has quick-binding, promotes the effects such as wound healing, can partly replace wound suture.Doctor
With a long history with the use of binding agent, clinic has highly important effect, soft group can be divided into
Knit with binding agent, dental binding agent, bone cement and skin binding agent etc..Wherein, soft group
Knitting with binding agent with biological tissue for bonding object, human body overwhelming majority tissue, organ are in treatment
During can apply adhering technique replace part sew up, ligation operation, it is not necessary to anesthesia.Soft
Tissue adhesive's purpose is to promote the normal healing of tissue itself, but the bonding of existing soft tissue
Agent comes with some shortcomings, such as bonding strength deficiency, function singleness etc..Accordingly, it would be desirable to develop
A kind of high bonding strength also has the soft tissue binding agent of antiinflammatory biocidal efficacies.
Summary of the invention
It is an object of the invention to provide a kind of soft tissue bonding with antiinflammatory biocidal efficacies
Agent.
To achieve these goals, the invention provides a kind of soft group with antiinflammatory biocidal efficacies
Knit with binding agent, comprise following parts by weight of component: polyether-ether-ketone 70-80 part, Rhopilema esculenta collagen
12-17 part, chitin 5-11 part, metronidazole 3-8 part, citrate 4-7 part, second two
Alcohol 2-8 part, chitosan lactate 12-20 part, Fructus Gleditsia powder 5-8 part, Radix Paeoniae Rubra powder 7-11 part,
Tricalcium phosphate 3-8 part, panthenol 5-8 part, tea polyphenols 5-10 part, sodium carboxymethyl cellulose
5-10 part.
It also comprises lecithin 11-14 part.
It also comprises tea tree ethereal oil 8-10 part.
It also comprises Herba Pogostemonis powder 10-20 part.
Its preparation method is: weigh each raw material by weight, adds raw materials in container, in room
Under temperature after ultrasonic 1-6h, it is then heated to 40-100 DEG C, stirs 1-3h, then the place that carries out disinfection
Manage.
Beneficial effect: a kind of soft tissue binding agent with antiinflammatory biocidal efficacies of the present invention has
There are higher adhesion strength and comprcssive strength, bio-tissue stimulated little, has without any
Evil reagent, also has effect of antiinflammatory sterilization, is suitable in surgical operation, is especially suitable for
The bonding of soft tissue.
Detailed description of the invention
Embodiment 1
The soft tissue binding agent with antiinflammatory biocidal efficacies of the present embodiment, comprises following weight
Part component: polyether-ether-ketone 70 parts, Rhopilema esculenta collagen 12 parts, chitin 5 parts, metronidazole 3 parts,
Citrate 4 parts, ethylene glycol 2 parts, chitosan lactate 12 parts, 5 parts of Fructus Gleditsia powder, red
7 parts of Chinese herbaceous peony powder, tricalcium phosphate 3 parts, panthenol 5 parts, tea polyphenols 5 parts, carboxymethyl cellulose
5 parts of sodium.
Embodiment 2
The soft tissue binding agent with antiinflammatory biocidal efficacies of the present embodiment, comprises following weight
Part component: polyether-ether-ketone 80 parts, Rhopilema esculenta collagen 17 parts, chitin 11 parts, metronidazole 8
Part, citrate 7 parts, ethylene glycol 8 parts, chitosan lactate 20 parts, 8 parts of Fructus Gleditsia powder,
11 parts of Radix Paeoniae Rubra powder, tricalcium phosphate 8 parts, panthenol 8 parts, tea polyphenols 10 parts, carboxymethyl are fine
Dimension element 10 parts of sodium, 14 parts of lecithin.
Embodiment 3
The soft tissue binding agent with antiinflammatory biocidal efficacies of the present embodiment, comprises following weight
Part component: polyether-ether-ketone 70 parts, Rhopilema esculenta collagen 12 parts, chitin 5 parts, metronidazole 3 parts,
Citrate 4 parts, ethylene glycol 2 parts, chitosan lactate 12 parts, 5 parts of Fructus Gleditsia powder, red
7 parts of Chinese herbaceous peony powder, tricalcium phosphate 3 parts, panthenol 5 parts, tea polyphenols 5 parts, carboxymethyl cellulose
5 parts of sodium, 11 parts of lecithin, tea tree ethereal oil 8 parts.
Embodiment 4
The soft tissue binding agent with antiinflammatory biocidal efficacies of the present embodiment, comprises following weight
Part component: polyether-ether-ketone 80 parts, Rhopilema esculenta collagen 17 parts, chitin 11 parts, metronidazole 8
Part, citrate 7 parts, ethylene glycol 8 parts, chitosan lactate 20 parts, 8 parts of Fructus Gleditsia powder,
11 parts of Radix Paeoniae Rubra powder, tricalcium phosphate 8 parts, panthenol 8 parts, tea polyphenols 10 parts, carboxymethyl are fine
Dimension element 10 parts of sodium, 14 parts of lecithin, tea tree ethereal oil 10 parts, 20 parts of Herba Pogostemonis powder.
The above, be only presently preferred embodiments of the present invention, not makees the present invention any
Pro forma restriction, although the present invention is disclosed above with preferred embodiment, but and is not used to
Limiting the present invention, any those skilled in the art, without departing from technical solution of the present invention
In the range of, when the technology contents of available the disclosure above makes a little change or is modified to equivalent change
The Equivalent embodiments changed, as long as being the content without departing from technical solution of the present invention, according to the present invention
Technical spirit any simple modification, equivalent variations and modification that above example is made, all
Still fall within the range of technical solution of the present invention.
Claims (4)
1. a soft tissue binding agent with antiinflammatory biocidal efficacies, it is characterised in that comprise
Following parts by weight of component: polyether-ether-ketone 70-80 part, Rhopilema esculenta collagen 12-17 part, chitin
5-11 part, metronidazole 3-8 part, citrate 4-7 part, ethylene glycol 2-8 part, chitosan
Lactate 12-20 part, Fructus Gleditsia powder 5-8 part, Radix Paeoniae Rubra powder 7-11 part, tricalcium phosphate 3-8 part,
Panthenol 5-8 part, tea polyphenols 5-10 part, sodium carboxymethyl cellulose 5-10 part.
The soft tissue bonding with antiinflammatory biocidal efficacies the most according to claim 1
Agent, it is characterised in that: it also comprises lecithin 11-14 part.
The soft tissue bonding with antiinflammatory biocidal efficacies the most according to claim 2
Agent, it is characterised in that: it also comprises tea tree ethereal oil 8-10 part.
The soft tissue binding agent with antiinflammatory biocidal efficacies the most according to claim 3,
It is characterized in that: it also comprises Herba Pogostemonis powder 10-20 part.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610398184.0A CN105999383A (en) | 2016-06-06 | 2016-06-06 | Anti-inflammatory sterilizing adhesive for soft tissue |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610398184.0A CN105999383A (en) | 2016-06-06 | 2016-06-06 | Anti-inflammatory sterilizing adhesive for soft tissue |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105999383A true CN105999383A (en) | 2016-10-12 |
Family
ID=57090745
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610398184.0A Withdrawn CN105999383A (en) | 2016-06-06 | 2016-06-06 | Anti-inflammatory sterilizing adhesive for soft tissue |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105999383A (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1732025A (en) * | 2002-12-24 | 2006-02-08 | 凯瑟琳·卡多雷尔 | Medical or veterinary material, method for the production and use thereof |
| CN101909667A (en) * | 2008-01-10 | 2010-12-08 | 爱乐康株式会社 | Pressure-sensitive adhesive agent for skin, pressure-sensitive adhesive sheet for skin and face plate of ostomy appliance |
| CN102596268A (en) * | 2009-11-20 | 2012-07-18 | 三井化学株式会社 | Adhesive composition for soft tissue, adhesive composition for covering wounds, or wound covering agent composition |
-
2016
- 2016-06-06 CN CN201610398184.0A patent/CN105999383A/en not_active Withdrawn
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1732025A (en) * | 2002-12-24 | 2006-02-08 | 凯瑟琳·卡多雷尔 | Medical or veterinary material, method for the production and use thereof |
| CN101909667A (en) * | 2008-01-10 | 2010-12-08 | 爱乐康株式会社 | Pressure-sensitive adhesive agent for skin, pressure-sensitive adhesive sheet for skin and face plate of ostomy appliance |
| CN102596268A (en) * | 2009-11-20 | 2012-07-18 | 三井化学株式会社 | Adhesive composition for soft tissue, adhesive composition for covering wounds, or wound covering agent composition |
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|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20161012 |
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| WW01 | Invention patent application withdrawn after publication |