CN106075611A - A kind of Antiadhesive film with antiphlogistic antibacterial effect - Google Patents
A kind of Antiadhesive film with antiphlogistic antibacterial effect Download PDFInfo
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- CN106075611A CN106075611A CN201610394365.6A CN201610394365A CN106075611A CN 106075611 A CN106075611 A CN 106075611A CN 201610394365 A CN201610394365 A CN 201610394365A CN 106075611 A CN106075611 A CN 106075611A
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- antibacterial effect
- antiphlogistic antibacterial
- antiadhesive film
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/16—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/148—Materials at least partially resorbable by the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/216—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with other specific functional groups, e.g. aldehydes, ketones, phenols, quaternary phosphonium groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/41—Anti-inflammatory agents, e.g. NSAIDs
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Surgery (AREA)
- Vascular Medicine (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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Abstract
The invention discloses a kind of Antiadhesive film with antiphlogistic antibacterial effect, it includes following component in parts by weight: PHA 40 50 parts, pectin from lemon peel 3 10 parts, metronidazole 38 parts, glycerol 5 15 parts, mupirocin 5 11 parts, dextropimaric acid 13 parts, divinylsulfone 28 parts, succinic acid 38 parts, 25 parts of glutamic acid, Radix Sangusorbae powder 11 14 parts, aloin 37 parts, 10 20 parts of Herba Pogostemonis powder.A kind of Antiadhesive film with antiphlogistic antibacterial effect of the present invention has effect of antiphlogistic antibacterial, good biocompatibility, degradable, and easy to use, biodegradability is good, non-stimulated to tissue, harmless to human non-toxic, can extensively apply and medical field.
Description
Technical field
The invention belongs to biomedical materials field, be specifically related to a kind of Antiadhesive film with antiphlogistic antibacterial effect.
Background technology
Biomaterial is for tissue and the diagnosis of organ, the class High-tech Material repairing or promoting its function,
I.e. being used for replacing, repairing living tissue natural or artificial material, its drugs with function is irreplaceable.Biomaterial can perform, promote
Or replace certain function lost because of disease, damage etc., and rejected region can not be recovered.Since the later stage nineties, the world is raw
Thing material science and technology develop rapidly, even if under the overall situation that current global economy is low, biomaterial still remains
Annual 13% rapid growth, has fully demonstrated its powerful vitality and vast potential for future development.Modern medicine forward regeneration and
Rebuild impaired tissue and organ, recover and promote the directions such as human body physiological function, personalization and minimally-invasive treatment and develop.
The conventional materials such as traditional abiotic medical metal, macromolecule, bioceramic can not meet the requirement of medical development, biological
Medical material scientific and engineering is faced with new opportunities and challenges.In future, the market share of bio-medical material may well
Medicine will be caught up with.Therefore, strengthen clinical application research and the popularization and application of bio-medical material, give priority to China's bio-medical
The research of material, develop, produce, the integrated system combined closely of marketing is the task of top priority.It practice, country is current at biology
Fundamentals of Material Science research aspect has been achieved for important breakthrough progress, walks in world's rank of advanced units, but industrialization level is still
Waiting to improve, industry size is little, development relatively lags behind, and is not met by being actually needed of Medicare health care.At national policy, warp
Under the support energetically of Ji, the industrialized development of China's biomaterial will speed-raising.Enterprise should strengthen the ability of autonomous innovation, further
Solve to rely on the situation of import, add large outlet dynamics, it is achieved spanning development simultaneously, expand Chinese biological material product in the world
Power of influence.
Biomaterial is widely used, and kind is a lot, and its sorting technique is the most a lot.Biomaterial includes that metal material is (such as alkali
Metal and alloy thereof etc.), inorganic material (bioactive ceramics, hydroxyapatite etc.) and organic material three major types.Organic material
In mainly polymeric set laminate material, macromolecular material is generally divided into synthesis macromolecular material (polyurethane, poly-by material properties
Ester, polylactic acid, polyglycolic acid, PLGA and other medical synthetic plastic and rubber etc.), natural macromolecular material
(such as collagen, fibroin, cellulose, chitosan etc.)；According to the purposes of material, these materials can be divided into again biologically inert
(bioinert), biological activity (bioactive) or biodegradation (biodegradable) material, in high molecular polymer, root
Can be by organism metabolism and absorption according to catabolite, degradation-type macromolecule can be divided into again Bioabsorbable and biological nonabsorable
Property.Blood compatible polymer and blood then it is divided into according to the state that affects on blood constituent, performance after material and contacting blood
Incompatibility.To the affinity of body cell and report situations according to material, biocompatibility and bio-incompatibility can be divided into
Polymer etc..Antiadhesive film just belongs to the one in macromolecular material, and Antiadhesive film is a kind of common medical consumptive material, with in case
The only postoperative bad adhesion unrelated with tissue repair, in order to avoid causing metaplasia, blocking, distort, cause serious consequence, such as
Cause the pain even functional disorder of biological tissue, the most even also need to other peeling operation bad viscous
Even.Therefore, the performance for adhesion membrane proposes the highest requirement, on the one hand, needs adhesion membrane to have good elasticity, does not damages
Injured tissue；On the other hand, need adhesion membrane can be easily separated, and there is good mechanical performance.Tissue adhesion is abdominal cavity, basin
Most common, the most thorny issue in the operative treatment of the position such as chamber, heart, it not only can cause serious complication, also be simultaneously
The main cause that second operation infectious-related complication probability of occurrence substantially rises.Generally, before surgical wound is sewed up, surgeon's meeting
The Antiadhesive film that one layer has physical isolation effect is placed between tissue or the organ of operation, thus prevents tissue and device
The generation of official's adhesion.But existing Antiadhesive film comes with some shortcomings, difficult after using such as non-degradable, act on single
Deng.Accordingly, it would be desirable to develop a kind of degradable and there is the Antiadhesive film of antiphlogistic antibacterial effect.
Summary of the invention
It is an object of the invention to provide a kind of Antiadhesive film with antiphlogistic antibacterial effect.
To achieve these goals, the invention provides a kind of Antiadhesive film with antiphlogistic antibacterial effect, including according to
The following component of parts by weight meter: PHA 40-50 part, pectin from lemon peel 3-10 part, metronidazole 3-8 part, glycerol 5-
15 parts, mupirocin 5-11 part, dextropimaric acid 1-3 part, divinylsulfone 2-8 part, succinic acid 3-8 part, glutamic acid 2-5 part, Radix Sanguisorbae
Powder 11-14 part, aloin 3-7 part, Herba Pogostemonis powder 10-20 part.
It also comprises sweet potato starch 15-20 part.
It also comprises Flos Inulae oil 6-10 part.
It also comprises Rhizoma Chuanxiong power 14-20 part.
Its preparation method is: weigh each raw material by weight, adds raw materials in container, after the most ultrasonic 1-6h,
It is then heated to 80-110 DEG C, after stirring 1-3h, stands 24h deaeration, be poured in glass mold, make film liquid nature levelling, level
Being placed in air dry oven 30-50 DEG C of freeze-day with constant temperature 3-12 hour, taken out by mould, cooling, ambient temperatare is put 12 hours, is taken off
Film, must have the Antiadhesive film of antiphlogistic antibacterial effect.
Beneficial effect: a kind of Antiadhesive film with antiphlogistic antibacterial effect of the present invention has effect of antiphlogistic antibacterial, raw
The thing compatibility is good, and degradable is easy to use, and biodegradability is good, non-stimulated to tissue, harmless to human non-toxic, permissible
Extensively application and medical field.
Detailed description of the invention
Embodiment 1
The Antiadhesive film with antiphlogistic antibacterial effect of the present embodiment, the following component including in parts by weight: poly-
Hydroxyalkanoate 40 parts, pectin from lemon peel 3 parts, metronidazole 3 parts, glycerol 5 parts, mupirocin 5 parts, dextropimaric acid 1 part, divinyl
Sulfone 2 parts, succinic acid 3 parts, 2 parts of glutamic acid, Radix Sangusorbae powder 11 parts, aloin 3 parts, 10 parts of Herba Pogostemonis powder.
Embodiment 2
The Antiadhesive film with antiphlogistic antibacterial effect of the present embodiment, the following component including in parts by weight: poly-
Hydroxyalkanoate 50 parts, pectin from lemon peel 10 parts, metronidazole 8 parts, glycerol 15 parts, mupirocin 11 parts, dextropimaric acid 3 parts, diethyl
Thiazolinyl sulfone 8 parts, succinic acid 8 parts, 5 parts of glutamic acid, Radix Sangusorbae powder 14 parts, aloin 7 parts, 20 parts of Herba Pogostemonis powder, sweet potato starch 20 parts.
Embodiment 3
The Antiadhesive film with antiphlogistic antibacterial effect of the present embodiment, the following component including in parts by weight: poly-
Hydroxyalkanoate 40 parts, pectin from lemon peel 3 parts, metronidazole 3 parts, glycerol 5 parts, mupirocin 5 parts, dextropimaric acid 1 part, divinyl
Sulfone 2 parts, succinic acid 3 parts, 2 parts of glutamic acid, Radix Sangusorbae powder 11 parts, aloin 3 parts, 10 parts of Herba Pogostemonis powder, sweet potato starch 15 parts, Flos Inulae
Oil 6 parts.
Embodiment 4
The Antiadhesive film with antiphlogistic antibacterial effect of the present embodiment, the following component including in parts by weight: poly-
Hydroxyalkanoate 50 parts, pectin from lemon peel 10 parts, metronidazole 8 parts, glycerol 15 parts, mupirocin 11 parts, dextropimaric acid 3 parts, diethyl
Thiazolinyl sulfone 8 parts, succinic acid 8 parts, 5 parts of glutamic acid, Radix Sangusorbae powder 14 parts, aloin 7 parts, 20 parts of Herba Pogostemonis powder, sweet potato starch 20 parts, gold
Small cup caul-fat 10 parts, Rhizoma Chuanxiong power 20 parts.
The above, be only presently preferred embodiments of the present invention, and the present invention not makees any pro forma restriction, though
So the present invention is disclosed above with preferred embodiment, but is not limited to the present invention, any technology people being familiar with this specialty
Member, in the range of without departing from technical solution of the present invention, when the technology contents of available the disclosure above makes a little change or modification
For the Equivalent embodiments of equivalent variations, as long as being the content without departing from technical solution of the present invention, the technical spirit of the foundation present invention
Any simple modification, equivalent variations and the modification being made above example, all still falls within the range of technical solution of the present invention.
Claims (4)
1. an Antiadhesive film with antiphlogistic antibacterial effect, it is characterised in that include following component in parts by weight:
PHA 40-50 part, pectin from lemon peel 3-10 part, metronidazole 3-8 part, glycerol 5-15 part, mupirocin 5-11 part, sea
Pine acid 1-3 part, divinylsulfone 2-8 part, succinic acid 3-8 part, glutamic acid 2-5 part, Radix Sangusorbae powder 11-14 part, aloin 3-7 part,
Herba Pogostemonis powder 10-20 part.
The Antiadhesive film with antiphlogistic antibacterial effect the most according to claim 1, it is characterised in that: it also comprises Rhizoma Dioscoreae esculentae and forms sediment
Powder 15-20 part.
The Antiadhesive film with antiphlogistic antibacterial effect the most according to claim 2, it is characterised in that: it also comprises Flos Inulae
Oil 6-10 part.
The Antiadhesive film with antiphlogistic antibacterial effect the most according to claim 3, it is characterised in that: it also comprises Rhizoma Chuanxiong power
14-20 part.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610394365.6A CN106075611A (en) | 2016-06-06 | 2016-06-06 | A kind of Antiadhesive film with antiphlogistic antibacterial effect |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610394365.6A CN106075611A (en) | 2016-06-06 | 2016-06-06 | A kind of Antiadhesive film with antiphlogistic antibacterial effect |
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| CN106075611A true CN106075611A (en) | 2016-11-09 |
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| CN201610394365.6A Withdrawn CN106075611A (en) | 2016-06-06 | 2016-06-06 | A kind of Antiadhesive film with antiphlogistic antibacterial effect |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108452391A (en) * | 2018-02-07 | 2018-08-28 | 苏州元禾医疗器械有限公司 | A kind of preparation method of Absorbable membranes |
| CN108578788A (en) * | 2018-02-07 | 2018-09-28 | 苏州元禾医疗器械有限公司 | A kind of Absorbable membranes |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1739491A (en) * | 2005-09-15 | 2006-03-01 | 同济大学 | A kind of nanometer fiber slow-releasing system and its production and application |
| CN1961974A (en) * | 2005-11-09 | 2007-05-16 | 中国科学院化学研究所 | Nano copolymer fibrous membrane material capable of being biodegraded and absorbed and preparation process and use thereof |
-
2016
- 2016-06-06 CN CN201610394365.6A patent/CN106075611A/en not_active Withdrawn
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1739491A (en) * | 2005-09-15 | 2006-03-01 | 同济大学 | A kind of nanometer fiber slow-releasing system and its production and application |
| CN1961974A (en) * | 2005-11-09 | 2007-05-16 | 中国科学院化学研究所 | Nano copolymer fibrous membrane material capable of being biodegraded and absorbed and preparation process and use thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108452391A (en) * | 2018-02-07 | 2018-08-28 | 苏州元禾医疗器械有限公司 | A kind of preparation method of Absorbable membranes |
| CN108578788A (en) * | 2018-02-07 | 2018-09-28 | 苏州元禾医疗器械有限公司 | A kind of Absorbable membranes |
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Application publication date: 20161109 |
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