CN106075545A - A kind of soft tissue binding agent with antibacterial anti hemorrhagic effect - Google Patents
A kind of soft tissue binding agent with antibacterial anti hemorrhagic effect Download PDFInfo
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- CN106075545A CN106075545A CN201610423618.8A CN201610423618A CN106075545A CN 106075545 A CN106075545 A CN 106075545A CN 201610423618 A CN201610423618 A CN 201610423618A CN 106075545 A CN106075545 A CN 106075545A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/0005—Ingredients of undetermined constitution or reaction products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
- A61L24/0015—Medicaments; Biocides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/046—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/06—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/08—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/10—Polypeptides; Proteins
- A61L24/108—Specific proteins or polypeptides not covered by groups A61L24/102 - A61L24/106
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/216—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with other specific functional groups, e.g. aldehydes, ketones, phenols, quaternary phosphonium groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/418—Agents promoting blood coagulation, blood-clotting agents, embolising agents
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Surgery (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Materials Engineering (AREA)
- Engineering & Computer Science (AREA)
- Materials For Medical Uses (AREA)
Abstract
The invention discloses a kind of soft tissue binding agent with antibacterial anti hemorrhagic effect, it comprises following parts by weight of component: polymethyl methacrylate 65 75 parts, chitin 5 11 parts, cellulose 11 14 parts, 46 parts of agar, mupirocin 5 11 parts, ethyl acetate 5 11 parts, degreased pupa powder 25 parts, dittany corium farinosum 5 15 parts, Radix Sangusorbae powder 11 14 parts, 25 parts of glutamic acid, stannous octoate 35 parts, sodium carboxymethyl cellulose 5 10 parts.A kind of soft tissue binding agent with antibacterial anti hemorrhagic effect of the present invention has higher adhesion strength and comprcssive strength, bio-tissue is stimulated little, without any harmful reagent, also there is effect of antibacterial anti hemorrhagic, it is suitable in surgical operation, is especially suitable for the bonding of soft tissue.
Description
Technical field
The invention belongs to biomedical materials field, be specifically related to a kind of soft tissue bonding with antibacterial anti hemorrhagic effect
Agent.
Background technology
Biomaterial is for tissue and the diagnosis of organ, the class High-tech Material repairing or promoting its function,
I.e. being used for replacing, repairing living tissue natural or artificial material, its drugs with function is irreplaceable.Biomaterial can perform, promote
Or replace certain function lost because of disease, damage etc., and rejected region can not be recovered.Since the later stage nineties, the world is raw
Thing material science and technology develop rapidly, even if under the overall situation that current global economy is low, biomaterial still remains
Annual 13% rapid growth, has fully demonstrated its powerful vitality and vast potential for future development.Modern medicine forward regeneration and
Rebuild impaired tissue and organ, recover and promote the directions such as human body physiological function, personalization and minimally-invasive treatment and develop.
The conventional materials such as traditional abiotic medical metal, macromolecule, bioceramic can not meet the requirement of medical development, biological
Medical material scientific and engineering is faced with new opportunities and challenges.In future, the market share of bio-medical material may well
Medicine will be caught up with.Therefore, strengthen clinical application research and the popularization and application of bio-medical material, give priority to China's bio-medical
The research of material, develop, produce, the integrated system combined closely of marketing is the task of top priority.It practice, country is current at biology
Fundamentals of Material Science research aspect has been achieved for important breakthrough progress, walks in world's rank of advanced units, but industrialization level is still
Waiting to improve, industry size is little, development relatively lags behind, and is not met by being actually needed of Medicare health care.At national policy, warp
Under the support energetically of Ji, the industrialized development of China's biomaterial will speed-raising.Enterprise should strengthen the ability of autonomous innovation, further
Solve to rely on the situation of import, add large outlet dynamics, it is achieved spanning development simultaneously, expand Chinese biological material product in the world
Power of influence.
Biomaterial is widely used, and kind is a lot, and its sorting technique is the most a lot.Biomaterial includes that metal material is (such as alkali
Metal and alloy thereof etc.), inorganic material (bioactive ceramics, hydroxyapatite etc.) and organic material three major types.Organic material
In mainly polymeric set laminate material, macromolecular material is generally divided into synthesis macromolecular material (polyurethane, poly-by material properties
Ester, polylactic acid, polyglycolic acid, PLGA and other medical synthetic plastic and rubber etc.), natural macromolecular material
(such as collagen, fibroin, cellulose, chitosan etc.)；According to the purposes of material, these materials can be divided into again biologically inert
(bioinert), biological activity (bioactive) or biodegradation (biodegradable) material, in high molecular polymer, root
Can be by organism metabolism and absorption according to catabolite, degradation-type macromolecule can be divided into again Bioabsorbable and biological nonabsorable
Property.Blood compatible polymer and blood then it is divided into according to the state that affects on blood constituent, performance after material and contacting blood
Incompatibility.To the affinity of body cell and report situations according to material, biocompatibility and bio-incompatibility can be divided into
Polymer etc..
Adhesive of medical just belongs to the one in biodegradation material, adhesive of medical be mainly used in various traumatic wounds,
The various operation of the surgery such as cosmetic surgery, family planning, it has quick-binding, promotes that wound healing etc. is made biological tissue of human body
With, can partly replace wound suture.The use of adhesive of medical is with a long history, has highly important effect in clinic, can divide
For soft tissue binding agent, dental binding agent, bone cement and skin binding agent etc..Wherein, soft tissue binding agent is with life
Fabric texture is bonding object, and human body overwhelming majority tissue, organ can apply adhering technique replacement part over the course for the treatment of
Sew up, ligation operation, it is not necessary to anesthesia.Soft tissue adhesives purpose is to promote the normal healing of tissue itself, but existing soft
Tissue adhesive comes with some shortcomings, such as bonding strength deficiency, function singleness etc..Accordingly, it would be desirable to it is strong to develop a kind of high bonding
Spend and have the soft tissue binding agent of antibacterial anti hemorrhagic effect.
Summary of the invention
It is an object of the invention to provide a kind of soft tissue binding agent with antibacterial anti hemorrhagic effect.
To achieve these goals, the invention provides a kind of soft tissue binding agent with antibacterial anti hemorrhagic effect, bag
Containing following parts by weight of component: polymethyl methacrylate 65-75 part, chitin 5-11 part, cellulose 11-14 part, agar 4-6
Part, mupirocin 5-11 part, ethyl acetate 5-11 part, degreased pupa powder 2-5 part, dittany corium farinosum 5-15 part, Radix Sangusorbae powder 11-14
Part, glutamic acid 2-5 part, stannous octoate 3-5 part, sodium carboxymethyl cellulose 5-10 part.
It also comprises neutral lipase 3-8 part.
It also comprises azone 3-7 part.
It also comprises carbomer 3-5 part.
Its preparation method is: weigh each raw material by weight, adds raw materials in container, after the most ultrasonic 1-6h,
It is then heated to 40-100 DEG C, stirs 1-3h, then disinfection.
Beneficial effect: it is strong that a kind of soft tissue binding agent with antibacterial anti hemorrhagic effect of the present invention has higher bonding
Degree and comprcssive strength, stimulate little to bio-tissue, without any harmful reagent, also have effect of antibacterial anti hemorrhagic, is suitable for
In surgical operation, it is especially suitable for the bonding of soft tissue.
Detailed description of the invention
Embodiment 1
The soft tissue binding agent with antibacterial anti hemorrhagic effect of the present embodiment, comprises following parts by weight of component: poly-methyl
Acrylic acid methyl ester. 65 parts, chitin 5 parts, cellulose 11 parts, 4 parts of agar, mupirocin 5 parts, ethyl acetate 5 parts, defat Pupa bombycis
2 parts of powder, dittany corium farinosum 5 parts, Radix Sangusorbae powder 11 parts, 2 parts of glutamic acid, stannous octoate 3 parts, sodium carboxymethyl cellulose 5 parts.
Embodiment 2
The soft tissue binding agent with antibacterial anti hemorrhagic effect of the present embodiment, comprises following parts by weight of component: poly-methyl
Acrylic acid methyl ester. 75 parts, chitin 11 parts, cellulose 14 parts, 6 parts of agar, mupirocin 11 parts, ethyl acetate 11 parts, defat silkworm
5 parts of pupa powder, dittany corium farinosum 15 parts, Radix Sangusorbae powder 14 parts, 5 parts of glutamic acid, stannous octoate 5 parts, sodium carboxymethyl cellulose 10 parts, neutrality
Lipase 8 parts.
Embodiment 3
The soft tissue binding agent with antibacterial anti hemorrhagic effect of the present embodiment, comprises following parts by weight of component: poly-methyl
Acrylic acid methyl ester. 65 parts, chitin 5 parts, cellulose 11 parts, 4 parts of agar, mupirocin 5 parts, ethyl acetate 5 parts, defat Pupa bombycis
2 parts of powder, dittany corium farinosum 5 parts, Radix Sangusorbae powder 11 parts, 2 parts of glutamic acid, stannous octoate 3 parts, sodium carboxymethyl cellulose 5 parts, neutral fat
Enzyme 3 parts, azone 3 parts.
Embodiment 4
The soft tissue binding agent with antibacterial anti hemorrhagic effect of the present embodiment, comprises following parts by weight of component: poly-methyl
Acrylic acid methyl ester. 75 parts, chitin 11 parts, cellulose 14 parts, 6 parts of agar, mupirocin 11 parts, ethyl acetate 11 parts, defat silkworm
5 parts of pupa powder, dittany corium farinosum 15 parts, Radix Sangusorbae powder 14 parts, 5 parts of glutamic acid, stannous octoate 5 parts, sodium carboxymethyl cellulose 10 parts, neutrality
Lipase 8 parts, azone 7 parts, carbomer 5 parts.
The above, be only presently preferred embodiments of the present invention, and the present invention not makees any pro forma restriction, though
So the present invention is disclosed above with preferred embodiment, but is not limited to the present invention, any technology people being familiar with this specialty
Member, in the range of without departing from technical solution of the present invention, when the technology contents of available the disclosure above makes a little change or modification
For the Equivalent embodiments of equivalent variations, as long as being the content without departing from technical solution of the present invention, the technical spirit of the foundation present invention
Any simple modification, equivalent variations and the modification being made above example, all still falls within the range of technical solution of the present invention.
Claims (4)
1. a soft tissue binding agent with antibacterial anti hemorrhagic effect, it is characterised in that comprise following parts by weight of component: poly-first
Base acrylic acid methyl ester. 65-75 part, chitin 5-11 part, cellulose 11-14 part, agar 4-6 part, mupirocin 5-11 part, acetic acid
Ethyl ester 5-11 part, degreased pupa powder 2-5 part, dittany corium farinosum 5-15 part, Radix Sangusorbae powder 11-14 part, glutamic acid 2-5 part, stannous octoate
3-5 part, sodium carboxymethyl cellulose 5-10 part.
The soft tissue binding agent with antibacterial anti hemorrhagic effect the most according to claim 1, it is characterised in that: it also comprises
Neutral lipase 3-8 part.
The soft tissue binding agent with antibacterial anti hemorrhagic effect the most according to claim 2, it is characterised in that: it also comprises
Azone 3-7 part.
The soft tissue binding agent with antibacterial anti hemorrhagic effect the most according to claim 3, it is characterised in that: it also comprises
Carbomer 3-5 part.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610423618.8A CN106075545A (en) | 2016-06-15 | 2016-06-15 | A kind of soft tissue binding agent with antibacterial anti hemorrhagic effect |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610423618.8A CN106075545A (en) | 2016-06-15 | 2016-06-15 | A kind of soft tissue binding agent with antibacterial anti hemorrhagic effect |
Publications (1)
| Publication Number | Publication Date |
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| CN106075545A true CN106075545A (en) | 2016-11-09 |
Family
ID=57845654
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| Application Number | Title | Priority Date | Filing Date |
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| CN201610423618.8A Withdrawn CN106075545A (en) | 2016-06-15 | 2016-06-15 | A kind of soft tissue binding agent with antibacterial anti hemorrhagic effect |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019183876A1 (en) * | 2018-03-29 | 2019-10-03 | The Procter & Gamble Company | Oral care compositions for promoting gum health |
| US10596088B2 (en) | 2018-03-29 | 2020-03-24 | The Procter & Gamble Company | Oral care compositions for promoting gum health |
| US10596089B2 (en) | 2018-03-29 | 2020-03-24 | The Procter & Gamble Company | Oral care compositions for promoting gum health |
| US10603263B2 (en) | 2018-03-29 | 2020-03-31 | The Procter & Gamble Company | Oral care compositions for promoting gum health |
| US11622925B2 (en) | 2019-09-30 | 2023-04-11 | The Procter & Gamble Company | Dentifrice compositions for treatment of dental biofilm |
| US11690792B2 (en) | 2019-09-30 | 2023-07-04 | The Procter & Gamble Company | Oral care compositions comprising hops beta acids and metal ions |
| US11813343B2 (en) | 2019-09-30 | 2023-11-14 | The Procter & Gamble Company | Dentifrice compositions for treatment of dental biofilm |
| US11918681B2 (en) | 2019-09-30 | 2024-03-05 | The Procter & Gamble Company | Oral care compositions comprising hops beta acid and amino acid |
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Cited By (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10980728B2 (en) | 2018-03-29 | 2021-04-20 | The Procter & Gamble Company | Oral care compositions for promoting gum health |
| US11642296B2 (en) | 2018-03-29 | 2023-05-09 | The Procter & Gamble Company | Oral care compositions for promoting gum health |
| WO2019183876A1 (en) * | 2018-03-29 | 2019-10-03 | The Procter & Gamble Company | Oral care compositions for promoting gum health |
| US10603263B2 (en) | 2018-03-29 | 2020-03-31 | The Procter & Gamble Company | Oral care compositions for promoting gum health |
| US10813863B2 (en) | 2018-03-29 | 2020-10-27 | The Procter & Gamble Company | Oral care compositions for promoting gum health |
| US10813864B2 (en) | 2018-03-29 | 2020-10-27 | The Procter & Gamble Company | Oral care compositions for promoting gum health |
| CN111936114A (en) * | 2018-03-29 | 2020-11-13 | 宝洁公司 | Oral care composition for promoting gum health |
| US10905642B2 (en) | 2018-03-29 | 2021-02-02 | The Procter & Gamble Company | Oral care compositions for promoting gum health |
| US10973746B2 (en) | 2018-03-29 | 2021-04-13 | The Procter & Gamble Company | Oral care compositions for promoting gum health |
| US11090232B2 (en) | 2018-03-29 | 2021-08-17 | The Procter & Gamble Company | Oral care compositions for promoting gum health |
| US10596089B2 (en) | 2018-03-29 | 2020-03-24 | The Procter & Gamble Company | Oral care compositions for promoting gum health |
| JP2021516245A (en) * | 2018-03-29 | 2021-07-01 | ザ プロクター アンド ギャンブル カンパニーＴｈｅ Ｐｒｏｃｔｅｒ ＆ Ｇａｍｂｌｅ Ｃｏｍｐａｎｙ | Oral care composition to promote gingival health |
| US10973745B2 (en) | 2018-03-29 | 2021-04-13 | The Procter & Gamble Company | Oral care compositions for promoting gum health |
| JP7058341B2 (en) | 2018-03-29 | 2022-04-21 | ザ プロクター アンド ギャンブル カンパニー | Oral care composition to promote gingival health |
| US11622926B2 (en) | 2018-03-29 | 2023-04-11 | The Procter & Gamble Company | Oral care compositions for promoting gum health |
| US11911495B2 (en) | 2018-03-29 | 2024-02-27 | The Procter & Gamble Company | Oral care compositions for promoting gum health |
| US10596088B2 (en) | 2018-03-29 | 2020-03-24 | The Procter & Gamble Company | Oral care compositions for promoting gum health |
| CN111936114B (en) * | 2018-03-29 | 2023-11-17 | 宝洁公司 | Oral care composition for promoting gingival health |
| US11696881B2 (en) | 2019-09-30 | 2023-07-11 | The Procter & Gamble Company | Oral care compositions comprising hops beta acids and fluoride ions |
| US11813343B2 (en) | 2019-09-30 | 2023-11-14 | The Procter & Gamble Company | Dentifrice compositions for treatment of dental biofilm |
| US11690792B2 (en) | 2019-09-30 | 2023-07-04 | The Procter & Gamble Company | Oral care compositions comprising hops beta acids and metal ions |
| US11622925B2 (en) | 2019-09-30 | 2023-04-11 | The Procter & Gamble Company | Dentifrice compositions for treatment of dental biofilm |
| US11918681B2 (en) | 2019-09-30 | 2024-03-05 | The Procter & Gamble Company | Oral care compositions comprising hops beta acid and amino acid |
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Application publication date: 20161109 |