CN105998556A - 一种治疗心律失常的中药组合物 - Google Patents
一种治疗心律失常的中药组合物 Download PDFInfo
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Abstract
本发明公开了一种治疗心律失常的中药组合物，其中药原料及重量份配比为：丹参10‑30份，鹿衔草10‑20份，钩藤10‑20份，七叶一枝花5‑15份，桂枝10‑20份，头发七10‑20份，昙花10‑20份，玳瑁5‑15份，茜草10‑20份，牡蛎10‑20份，回心草10‑20份，黄连5‑15份，凤尾参10‑20份，龟板10‑20份，红景天5‑15份，龙齿10‑20份，千针万线草10‑20份，酸枣仁10‑20份，乌金草5‑15份，远志10‑20份，黑点草10‑20份，西红花5‑15份，短柄五加10‑20份，甘草5‑15份。其具有养肝解郁、活血通经络、健脾益气、宁心安神的功效，治疗心律失常疗效显著，安全可靠。
Description
技术领域
本发明涉及一种传统草药的未确定结构的医用配制品，尤其是一种治疗心律失常的中药组合物。
背景技术
心律失常是由于窦房结激动异常或激动产生于窦房结以外，激动的传导缓慢、阻滞或经异常通道传导，即心脏活动的起源和/或传导障碍导致心脏搏动的频率和/或节律异常。心律失常是心血管疾病中重要的一组疾病。它可单独发病，亦可与其他心血管病伴发。临床表现主要取决于心律失常的性质、类型、心功能及对血液动力学影响的程度，常见的症状有：心悸、胸闷、头晕、低血压、出汗，严重者可出现晕厥、阿-斯综合征，甚至猝死。目前，现代医学上对于心律失常的治疗一般以抗心律失常药物为主，虽具有一定效果，但长期服用抗心律失常药均有不同程度的副作用，严重的可引起室性心律失常或心脏传导阻滞而致命。
中医认为，心律失常属于中医“心悸”、“怔忡”、“胸痹”、“心痛”等范畴，多由于脏腑气血阴阳虚损、内伤七情、气滞血瘀交互作用致心失所养、心脉失畅而引起。
根据中医理论，针对心律失常的发病机理，以补血养心，益气安神为治则，进行辩证配伍组方，以达到标本兼治的目的。
发明内容
为了克服现有技术中采用抗心律失常药物治疗心律失常存在副作用大的不足，本发明提供一种配制方便、疗效显著、安全可靠的治疗心律失常的中药组合物。
本发明解决其技术问题所采用的技术方案是：一种治疗心律失常的中药组合物，其特征在于：其中药原料及重量份配比为：丹参10-30份，鹿衔草10-20份，钩藤10-20份，七叶一枝花5-15份，桂枝10-20份，头发七10-20份，昙花10-20份，玳瑁5-15份，茜草10-20份，牡蛎10-20份，回心草10-20份，黄连5-15份，凤尾参10-20份，龟板10-20份，红景天5-15份，龙齿10-20份，千针万线草10-20份，酸枣仁10-20份，乌金草5-15份，远志10-20份，黑点草10-20份，西红花5-15份，短柄五加10-20份，甘草5-15份。
本发明的优选技术方案是：一种治疗心律失常的中药组合物，其特征在于：其中药原料及重量份配比为：丹参20份，鹿衔草15份，钩藤15份，七叶一枝花10份，桂枝15份，头发七15份，昙花15份，玳瑁10份，茜草15份，牡蛎15份，回心草15份，黄连10份，凤尾参15份，龟板15份，红景天10份，龙齿15份，千针万线草15份，酸枣仁15份，乌金草10份，远志15份，黑点草15份，西红花10份，短柄五加15份，甘草10份。
本发明中药组合物是在传统中医理论和临床经验指导下，精选药物组方。本发明中药组合物中：丹参具有活血调经、祛瘀止痛、凉血消痈、清心除烦、养血安神的功效；鹿衔草具有补肾强骨、祛风除湿、止咳、止血的功效；钩藤具有清热平肝、熄风止痉的功效；七叶一枝花具有清热解毒、消肿止痛、晾肝定惊的功效；桂枝具有发汗解肌、温经通脉、助阳化气、散寒止痛的功效；头发七具有滋补肝肾、收敛止汗的功效；昙花具有清肺止咳、凉血止血、养心安神的功效；玳瑁具有平肝定惊、清热解毒的功效；茜草具有凉血止血、祛瘀通经的功效；牡蛎具有平肝潜阳、镇惊安神、软坚散结、收敛固涩的功效；回心草具有养心安神、镇静的功效；黄连具有清热燥湿、泻火解毒的功效；凤尾参具有补气血、通经络、止咳平喘的功效；龟板具有滋肾潜阳、益肾健骨、养血补心的功效；红景天具有补气清肺、益智养心、收涩止血、散瘀消肿的功效；龙齿具有镇惊安神、清热除烦的功效；千针万线草具有有补气健脾、养肝活血的功效；酸枣仁具有养肝敛汗、宁心安神的功效；乌金草具有平肝阳、养心安神、养血调经的功效；远志具有安神益智、祛痰镇惊、行气散郁的功效；黑点草具有清泄心火、疏风、利水的功效；西红花具有活血化瘀、凉血解毒、解郁安神的功效；短柄五加具有益气健脾、养心安神、解郁和血的功效；甘草具有补脾益气、清热解毒、祛痰止咳、调和诸药的功效。本发明组合物中的药物组分经辩证配伍，在作用上相辅相成，具有协同作用，共奏养肝解郁、活血通经络、健脾益气、宁心安神之功效，对心律失常达到标本兼治的目的。
本发明组合物的组分均采用天然的中药原料，其配制简便、药源广、成本低。其遵循中医的处方用药原则，各种组分药物采用水煎服用。经临床应用验证和中药品不良反应（ADR）安全性评价，其疗效显著，安全可靠，药性平和，未出现毒副作用，总有效率90%，治愈率达69%。
具体实施方式
下面结合实施例对本发明做进一步说明。
实施例
1
一种治疗心律失常的中药组合物，其中药原料及重量配比为：丹参20g，鹿衔草15g，钩藤15g，七叶一枝花10g，桂枝15g，头发七15g，昙花15g，玳瑁10g，茜草15g，牡蛎15g，回心草15g，黄连10g，凤尾参15g，龟板15g，红景天10g，龙齿15g，千针万线草15g，酸枣仁15g，乌金草10g，远志15g，黑点草15g，西红花10g，短柄五加15g，甘草10g。
实施例
2
一种治疗心律失常的中药组合物，其中药原料及重量配比为：丹参30g，鹿衔草10g，钩藤20g，七叶一枝花5g，桂枝20g，头发七10g，昙花20g，玳瑁5g，茜草20g，牡蛎10g，回心草20g，黄连5g，凤尾参20g，龟板10g，红景天15g，龙齿10g，千针万线草20g，酸枣仁10g，乌金草15g，远志10g，黑点草20g，西红花5g，短柄五加20g，甘草5g。
实施例
3
一种治疗心律失常的中药组合物，其中药原料及重量配比为：丹参10g，鹿衔草20g，钩藤10g，七叶一枝花15g，桂枝10g，头发七20g，昙花10g，玳瑁15g，茜草10g，牡蛎20g，回心草10g，黄连15g，凤尾参10g，龟板20g，红景天5g，龙齿20g，千针万线草10g，酸枣仁20g，乌金草5g，远志20g，黑点草10g，西红花15g，短柄五加10g，甘草15g。
实施例
4
一种治疗心律失常的中药组合物，其中药原料及重量配比为：丹参23g，鹿衔草12g，钩藤17g，七叶一枝花7g，桂枝18g，头发七12g，昙花18g，玳瑁7g，茜草18g，牡蛎12g，回心草18g，黄连7g，凤尾参18g，龟板12g，红景天13g，龙齿12g，千针万线草18g，酸枣仁12g，乌金草13g，远志12g，黑点草18g，西红花7g，短柄五加18g，甘草7g。
实施例
5
一种治疗心律失常的中药组合物，其中药原料及重量配比为：丹参17g，鹿衔草18g，钩藤12g，七叶一枝花13g，桂枝12g，头发七17g，昙花12g，玳瑁13g，茜草12g，牡蛎17g，回心草12g，黄连13g，凤尾参12g，龟板17g，红景天7g，龙齿18g，千针万线草12g，酸枣仁17g，乌金草7g，远志18g，黑点草12g，西红花13g，短柄五加12g，甘草13g。
本发明实施例中的中药组合物按常规的水煎法制取药剂。具体方法如下：将组方的中药原料放入容器中，加冷水漫过药面，浸泡15～20分钟，再加水没过药面约8厘米，进行第一次煎煮，未沸前采用武火煎煮，沸后用文火煎煮20～30分钟；第二次煎煮，加水没过药面约6厘米，水沸后煎煮15～20分钟。两次煎煮去渣取汁，合并。
本发明以实施例1所给出的一种治疗心律失常的中药组合物，做临床疗效总结如下：
一、一般性资料：本发明中药组合物应用于临床观察病例61例，其中男36例，女25例，年龄30～70岁。病程最短者4个月，最长者达6年，平均1年。
二、诊断标准：
1、临床表现常见症状为心悸、乏力、头晕，严重可出现晕厥阿斯综合症；
2、心电图表现窦性心动过缓(窦缓)，心室率每分钟多为45-60次，也可低于40次；
3、心电图表现窦性停搏时间较长可有昏厥；早搏病人常有心脏“突、突”地跳出胸腔的心慌感或心脏停跳的感觉，脉搏则有间断的缺如，脉搏次数少于心跳；
4、阵发性心动过速是阵发性发作，突然发作，突然消失，可反复发作，发作时心跳每分钟可达150-220次，可有心悸，心前区不适，眩晕，发作时间可持续数分钟至数小时，甚至数天；
5、心房颤动可有心跳不规则、脉搏快慢强弱不一，次数少于心跳；房室传导阻滞可有心跳脱汇、心率变慢或心跳暂停，甚至每分钟心跳仅有20-40次，出现昏厥、抽搐。
三、用法用量：临床应用时，一天一剂，水煎两遍取汁约400ml，分早、晚两次服用，六天一疗程。
四、疗效标准：
1、治愈：症状消失，心电图恢复正常；
2、好转：自觉症状改善，心律失常发作次数及频率较前明显减少；
3、未愈：症状和体征无明显改善。
五、治疗效果：该临床观察病例中，服药5-15个疗程，治愈42例，好转13例，未愈6例。治疗期间对中药品临床引起各类型的过敏反应、疑为药物引起人体各***、器官、组织的功能和形态方面的异常、疑为药物引起癌症等致突变反应、药物的依赖性以及认为重要或有价值的其他不良反应进行了评价，即中药品不良反应（ADR）评价，未发生不良反应和毒副作用。
六、典型病例：
病例1：刘某，男，55岁。患者就诊时自述：半年前无明显诱因出现胸闷，头晕，乏力，含服***后可缓解。近两个月来，发作频率较高，发作时间持续半小时，含服***不缓解。服用本发明的中药组合物制备的药剂5个疗程后，自觉不适感减轻，发作频率降低；继续服用4个疗程，症状消失，心电图检查显示为：正常，治愈。随访半年未复发。
病例2：王某，女，63岁。患者自述：胸闷、憋气3余年，医院心电图检查，诊为：心律不齐。平日运动后症状加重，伴大汗，头晕。期间一直服用抗心律失常的药物，效果并不明显。服用本发明的中药组合物制备的药剂6个疗程，心律失常发作次数明显减少，胸闷、憋气明显好转；续服3个疗程后，各症状消失，心电图恢复正常，治愈。
Claims (2)
1.一种治疗心律失常的中药组合物，其特征在于：其中药原料及重量份配比为：丹参10-30份，鹿衔草10-20份，钩藤10-20份，七叶一枝花5-15份，桂枝10-20份，头发七10-20份，昙花10-20份，玳瑁5-15份，茜草10-20份，牡蛎10-20份，回心草10-20份，黄连5-15份，凤尾参10-20份，龟板10-20份，红景天5-15份，龙齿10-20份，千针万线草10-20份，酸枣仁10-20份，乌金草5-15份，远志10-20份，黑点草10-20份，西红花5-15份，短柄五加10-20份，甘草5-15份。
2.根据权利要求1所述的一种治疗心律失常的中药组合物，其特征在于：其中药原料及重量份配比为：丹参20份，鹿衔草15份，钩藤15份，七叶一枝花10份，桂枝15份，头发七15份，昙花15份，玳瑁10份，茜草15份，牡蛎15份，回心草15份，黄连10份，凤尾参15份，龟板15份，红景天10份，龙齿15份，千针万线草15份，酸枣仁15份，乌金草10份，远志15份，黑点草15份，西红花10份，短柄五加15份，甘草10份。
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