CN105968025A - 3-(甲基苄基氨基)-2-(2,3,4,5-四氟苯甲酰基)丙烯酸乙酯的制备方法 - Google Patents
3-(甲基苄基氨基)-2-(2,3,4,5-四氟苯甲酰基)丙烯酸乙酯的制备方法 Download PDFInfo
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- CN105968025A CN105968025A CN201610314502.0A CN201610314502A CN105968025A CN 105968025 A CN105968025 A CN 105968025A CN 201610314502 A CN201610314502 A CN 201610314502A CN 105968025 A CN105968025 A CN 105968025A
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- methylbenzylamide
- ethyl acrylate
- formoxyl
- phenyl tetrafluoride
- solution
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/38—Separation; Purification; Stabilisation; Use of additives
- C07C227/40—Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/04—Formation of amino groups in compounds containing carboxyl groups
- C07C227/06—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/38—Separation; Purification; Stabilisation; Use of additives
- C07C227/40—Separation; Purification
- C07C227/42—Crystallisation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/58—Preparation of carboxylic acid halides
- C07C51/60—Preparation of carboxylic acid halides by conversion of carboxylic acids or their anhydrides or esters, lactones, salts into halides with the same carboxylic acid part
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Crystallography & Structural Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
Claims (10)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN201610314502.0A CN105968025B (zh) | 2016-05-13 | 2016-05-13 | 3-(甲基苄基氨基)-2-(2,3,4,5-四氟苯甲酰基)丙烯酸乙酯的制备方法 |
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CN201610314502.0A CN105968025B (zh) | 2016-05-13 | 2016-05-13 | 3-(甲基苄基氨基)-2-(2,3,4,5-四氟苯甲酰基)丙烯酸乙酯的制备方法 |
Publications (2)
Publication Number | Publication Date |
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CN105968025A true CN105968025A (zh) | 2016-09-28 |
CN105968025B CN105968025B (zh) | 2018-04-27 |
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CN201610314502.0A Active CN105968025B (zh) | 2016-05-13 | 2016-05-13 | 3-(甲基苄基氨基)-2-(2,3,4,5-四氟苯甲酰基)丙烯酸乙酯的制备方法 |
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CN (1) | CN105968025B (zh) |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102060860A (zh) * | 2011-01-07 | 2011-05-18 | 安徽美诺华药物化学有限公司 | 一种马波沙星的制备方法 |
CN102617595A (zh) * | 2012-03-23 | 2012-08-01 | 江西华士药业有限公司 | 氟喹诺酮类抗菌药马波沙星的制备方法 |
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2016
- 2016-05-13 CN CN201610314502.0A patent/CN105968025B/zh active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102060860A (zh) * | 2011-01-07 | 2011-05-18 | 安徽美诺华药物化学有限公司 | 一种马波沙星的制备方法 |
CN102617595A (zh) * | 2012-03-23 | 2012-08-01 | 江西华士药业有限公司 | 氟喹诺酮类抗菌药马波沙星的制备方法 |
Non-Patent Citations (1)
Title |
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*** 等: "马波沙星的合成工艺优化", 《广东化工》 * |
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Publication number | Publication date |
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CN105968025B (zh) | 2018-04-27 |
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CB03 | Change of inventor or designer information |
Inventor after: Zhang Yue Inventor after: Niu Zhaohuan Inventor after: Fu Yajing Inventor after: Li Xiaoyuan Inventor after: Zhao Shuchun Inventor after: Dong Xinrui Inventor before: Niu Zhaohuan Inventor before: Fu Yajing Inventor before: Zhang Yue Inventor before: Li Xiaoyuan Inventor before: Zhao Shuchun Inventor before: Dong Xinrui |
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