CN105963799A - Anti-infection anti-adhesion membrane - Google Patents

Anti-infection anti-adhesion membrane Download PDF

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Publication number
CN105963799A
CN105963799A CN201610430987.XA CN201610430987A CN105963799A CN 105963799 A CN105963799 A CN 105963799A CN 201610430987 A CN201610430987 A CN 201610430987A CN 105963799 A CN105963799 A CN 105963799A
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CN
China
Prior art keywords
parts
infective
antiadhesive film
infection
cellulose
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
CN201610430987.XA
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Chinese (zh)
Inventor
董荣琴
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HUZHOU KEDA CHEMICAL FUEL Co Ltd
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HUZHOU KEDA CHEMICAL FUEL Co Ltd
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Priority to CN201610430987.XA priority Critical patent/CN105963799A/en
Publication of CN105963799A publication Critical patent/CN105963799A/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/048—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/005—Ingredients of undetermined constitution or reaction products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/042—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/148—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/204—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with nitrogen-containing functional groups, e.g. aminoxides, nitriles, guanidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/418—Agents promoting blood coagulation, blood-clotting agents, embolising agents

Abstract

The invention discloses an anti-infection anti-adhesion membrane. The membrane is prepared from, by weight, 50-60 parts of polyvinyl alcohol, 5-8 parts of gum tragacanth, 10-15 parts of chitosan, 10-15 parts of cellulose, 3-8 parts of metronidazole, 2-8 parts of squalane, 5-10 parts of rhubarb, radix scutellariae and cortex phellodendri powder, 14-20 parts of rhizoma chuanxiong powder, 11-14 parts of sanguisorba officinalis, 5-8 parts of panthenol, 5-10 parts of tea polyphenol, 5-10 parts of sodium carboxymethyl cellulose and 3-9 parts of mannose. The anti-infection anti-adhesion membrane can effectively prevent wounds from being infected, and is good in biocompatibility, degradable, convenient to use, good in biodegradability, free of irritation to tissue, free of toxin and harm to human bodies and capable of being widely used in the medical field.

Description

A kind of anti-infective Antiadhesive film
Technical field
The invention belongs to biomedical materials field, be specifically related to a kind of anti-infective anti Film.
Background technology
Biomaterial is for tissue and the diagnosis of organ, repairs or promote the one of its function Class High-tech Material, is i.e. used for replacing, repairing living tissue natural or artificial material, its effect Medicine is irreplaceable.Biomaterial can perform, promote or replace because disease, damage etc. lose Certain function, and rejected region can not be recovered.Since the later stage nineties, world's biology material Material Science and Technology develops rapidly, even if under the overall situation that current global economy is low, biological Material still remains annual 13% rapid growth, has fully demonstrated its powerful vitality with wide Wealthy development prospect.The regeneration of modern medicine forward and rebuild impaired tissue and organ, Recover and promote the directions such as human body physiological function, personalization and minimally-invasive treatment to develop.Traditional nothing The conventional materials such as the medical metal of life, macromolecule, bioceramic can not meet medical development Requirement, biomedical material scientific and engineering is faced with new opportunities and challenges.Future, raw Medicine may well will be caught up with in the market share of thing medical material.Therefore, bio-medical is strengthened The clinical application research of material and popularization and application, give priority to grinding of China's bio-medical material Study carefully, develop, produce, the integrated system combined closely of marketing is the task of top priority.It practice, Country currently has been achieved for important breakthrough progress in terms of biomaterial scientific basic research, walks In world's rank of advanced units, but industrialization level waits to improve, and industry size is little, development is relative Delayed, it is not met by being actually needed of Medicare health care.In national policy, economic big Under power is supported, the industrialized development of China's biomaterial will speed-raising.Enterprise should strengthen autonomous innovation Ability, solve further to rely on the situation of import, add large outlet dynamics, it is achieved cross over simultaneously Development, expands Chinese biological material product power of influence in the world.
Biomaterial is widely used, and kind is a lot, and its sorting technique is the most a lot.Biomaterial bag Include metal material (such as alkali metal and alloy thereof etc.), inorganic material (bioactive ceramics, hydroxyl Base apatite etc.) and organic material three major types.Organic material is mainly polymeric set compound material Material, macromolecular material generally by material properties be divided into synthesis macromolecular material (polyurethane, polyester, Polylactic acid, polyglycolic acid, PLGA and other medical synthetic plastic and rubber Deng), natural macromolecular material (such as collagen, fibroin, cellulose, chitosan etc.)；According to The purposes of material, these materials can be divided into again biologically inert (bioinert), biological activity Or biodegradation (biodegradable) material, high molecular polymer (bioactive) In, can be by organism metabolism and absorption according to catabolite, degradation-type macromolecule can be divided into again life Thing absorbability and biological nonabsorable.According to after material and contacting blood to blood constituent, The state that affects of performance is then divided into blood compatible polymer and blood incompatibility.According to material To the affinity of body cell with report situations, biocompatibility and bio-incompatibility can be divided into Polymer etc..Antiadhesive film just belongs to the one in macromolecular material, and Antiadhesive film is a kind of normal The medical consumptive material seen, in order to prevent the postoperative bad adhesion unrelated with tissue repair, in order to avoid causing Metaplasia, block, distort, cause serious consequence, such as, cause the even biological group of pain The functional disorder knitted, the most even also needs to other peeling operation bad viscous Even.Therefore, the performance for adhesion membrane proposes the highest requirement, on the one hand, need adhesion Film has good elasticity, does not damage tissue；On the other hand, need adhesion membrane can be easily separated, And there is good mechanical performance.Tissue adhesion is the position operations such as abdominal cavity, pelvic cavity, heart Most common, the most thorny issue in treatment, it not only can cause serious complication, the most also It it is the main cause that substantially rises of second operation infectious-related complication probability of occurrence.Generally, in operation wound Mouthful sew up before, surgeon the Antiadhesive film that a layer has physical isolation effect can be placed on through Cross between tissue or the organ of operation, thus prevent the generation of tissue and organ adhesion.But it is existing Some Antiadhesive films come with some shortcomings, difficult after using such as non-degradable, act on single etc.. Accordingly, it would be desirable to develop a kind of degradable energy anti-infective Antiadhesive film.
Summary of the invention
It is an object of the invention to provide a kind of anti-infective Antiadhesive film.
To achieve these goals, the invention provides a kind of anti-infective Antiadhesive film, including Following component in parts by weight: polyvinyl alcohol 50-60 part, tragacanth 5-8 part, first Shell element 10-15 part, cellulose 10-15 part, metronidazole 3-8 part, squalane 2-8 part, three Bloom 5-10 part, Rhizoma Chuanxiong power 14-20 part, Radix Sangusorbae powder 11-14 part, panthenol 5-8 part, Tea polyphenols 5-10 part, sodium carboxymethyl cellulose 5-10 part, mannose 3-9 part.
It also comprises dextropimaric acid 1-3 part.
It also comprises polysorbate 4-12 part.
It also comprises lecithin 3-5 part.
Its preparation method is: weigh each raw material by weight, adds raw materials in container, in room Under temperature after ultrasonic 1-6h, it is then heated to 80-110 DEG C, after stirring 1-3h, stands 24h Deaeration, is poured in glass mold, makes film liquid nature levelling, is horizontally placed in air dry oven 30-50 DEG C of freeze-day with constant temperature 3-12 hour, takes out mould, and cooling, it is little that ambient temperatare puts 12 Time, take off film, obtain anti-infective Antiadhesive film.
Beneficial effect: a kind of anti-infective Antiadhesive film of the present invention can effectively prevent the sense of wound Dye, good biocompatibility, degradable, easy to use, biodegradability is good, to tissue Non-stimulated, harmless to human non-toxic, can extensively apply and medical field.
Detailed description of the invention
Embodiment 1
The anti-infective Antiadhesive film of the present embodiment, including in parts by weight following group Point: polyvinyl alcohol 50 parts, tragacanth 5 parts, chitin 10 parts, cellulose 10 parts, first Nitre azoles 3 parts, squalane 2 parts, SANHUANGFEN 5 parts, Rhizoma Chuanxiong power 14 parts, Radix Sangusorbae powder 11 parts, Panthenol 5 parts, tea polyphenols 5 parts, sodium carboxymethyl cellulose 5 parts, mannose 3 parts.
Embodiment 2
The anti-infective Antiadhesive film of the present embodiment, including in parts by weight following group Point: polyvinyl alcohol 60 parts, tragacanth 8 parts, chitin 15 parts, cellulose 15 parts, first Nitre azoles 8 parts, squalane 8 parts, SANHUANGFEN 10 parts, Rhizoma Chuanxiong power 20 parts, Radix Sangusorbae powder 14 parts, Panthenol 8 parts, tea polyphenols 10 parts, sodium carboxymethyl cellulose 10 parts, mannose 9 parts, sea Pine acid 3 parts.
Embodiment 3
The anti-infective Antiadhesive film of the present embodiment, including in parts by weight following group Point: polyvinyl alcohol 50 parts, tragacanth 5 parts, chitin 10 parts, cellulose 10 parts, first Nitre azoles 3 parts, squalane 2 parts, SANHUANGFEN 5 parts, Rhizoma Chuanxiong power 14 parts, Radix Sangusorbae powder 11 parts, Panthenol 5 parts, tea polyphenols 5 parts, sodium carboxymethyl cellulose 5 parts, mannose 3 parts, Korean pine Acid 1 part, polysorbate 4 parts.
Embodiment 4
The anti-infective Antiadhesive film of the present embodiment, including in parts by weight following group Point: polyvinyl alcohol 60 parts, tragacanth 8 parts, chitin 15 parts, cellulose 15 parts, first Nitre azoles 8 parts, squalane 8 parts, SANHUANGFEN 10 parts, Rhizoma Chuanxiong power 20 parts, Radix Sangusorbae powder 14 parts, Panthenol 8 parts, tea polyphenols 10 parts, sodium carboxymethyl cellulose 10 parts, mannose 9 parts, sea Pine acid 3 parts, polysorbate 12 parts, 5 parts of lecithin.
The above, be only presently preferred embodiments of the present invention, not makees the present invention any Pro forma restriction, although the present invention is disclosed above with preferred embodiment, but and is not used to Limiting the present invention, any those skilled in the art, without departing from technical solution of the present invention In the range of, when the technology contents of available the disclosure above makes a little change or is modified to equivalent change The Equivalent embodiments changed, as long as being the content without departing from technical solution of the present invention, according to the present invention Technical spirit any simple modification, equivalent variations and modification that above example is made, all Still fall within the range of technical solution of the present invention.

Claims (4)

1. an anti-infective Antiadhesive film, it is characterised in that include in parts by weight Following component: polyvinyl alcohol 50-60 part, tragacanth 5-8 part, chitin 10-15 part, fibre Dimension element 10-15 part, metronidazole 3-8 part, squalane 2-8 part, SANHUANGFEN 5-10 part, river Rhizome of chuanxiong powder 14-20 part, Radix Sangusorbae powder 11-14 part, panthenol 5-8 part, tea polyphenols 5-10 part, Sodium carboxymethyl cellulose 5-10 part, mannose 3-9 part.
Anti-infective Antiadhesive film the most according to claim 1, it is characterised in that: its Also comprise dextropimaric acid 1-3 part.
Anti-infective Antiadhesive film the most according to claim 2, it is characterised in that: its Also comprise polysorbate 4-12 part.
Anti-infective Antiadhesive film the most according to claim 3, it is characterised in that: its Also comprise lecithin 3-5 part.
CN201610430987.XA 2016-06-16 2016-06-16 Anti-infection anti-adhesion membrane Withdrawn CN105963799A (en)

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Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101623517A (en) * 2009-08-11 2010-01-13 广州迈普再生医学科技有限公司 Medical anti-sticking membrane and preparation method thereof
CN102698313A (en) * 2012-01-11 2012-10-03 北京大学 Nano-silver antibacterial hydrogel and preparation method thereof
CN103200971A (en) * 2010-08-30 2013-07-10 哈佛大学校长及研究员协会 A high strength chitin composite material and method of making
US8865857B2 (en) * 2010-07-01 2014-10-21 Sofradim Production Medical device with predefined activated cellular integration
CN104583182A (en) * 2012-05-23 2015-04-29 塞利克斯比奥私人有限公司 Compositions and methods for treatment of mucositis
WO2015074631A1 (en) * 2013-11-21 2015-05-28 Contipro Biotech S.R.O. Voluminous nanofibrous material based on hyaluronic acid, its salt or their derivatives, method of preparation thereof, method of modification thereof, modified nanofibrous material, nanofibrous structure and use thereof
CN105251038A (en) * 2015-10-09 2016-01-20 中国科学院长春应用化学研究所 Anti-infection soft tissue medical adhesive and preparation method thereof

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101623517A (en) * 2009-08-11 2010-01-13 广州迈普再生医学科技有限公司 Medical anti-sticking membrane and preparation method thereof
US8865857B2 (en) * 2010-07-01 2014-10-21 Sofradim Production Medical device with predefined activated cellular integration
CN103200971A (en) * 2010-08-30 2013-07-10 哈佛大学校长及研究员协会 A high strength chitin composite material and method of making
CN102698313A (en) * 2012-01-11 2012-10-03 北京大学 Nano-silver antibacterial hydrogel and preparation method thereof
CN104583182A (en) * 2012-05-23 2015-04-29 塞利克斯比奥私人有限公司 Compositions and methods for treatment of mucositis
WO2015074631A1 (en) * 2013-11-21 2015-05-28 Contipro Biotech S.R.O. Voluminous nanofibrous material based on hyaluronic acid, its salt or their derivatives, method of preparation thereof, method of modification thereof, modified nanofibrous material, nanofibrous structure and use thereof
CN105251038A (en) * 2015-10-09 2016-01-20 中国科学院长春应用化学研究所 Anti-infection soft tissue medical adhesive and preparation method thereof

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Application publication date: 20160928