CN105963756A - Medicinal dressing and preparation method thereof - Google Patents

Medicinal dressing and preparation method thereof Download PDF

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Publication number
CN105963756A
CN105963756A CN201610471317.2A CN201610471317A CN105963756A CN 105963756 A CN105963756 A CN 105963756A CN 201610471317 A CN201610471317 A CN 201610471317A CN 105963756 A CN105963756 A CN 105963756A
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temperature
parts
preparation
medicinal dressing
distilled water
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林春梅
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/28Polysaccharides or their derivatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42Use of materials characterised by their function or physical properties

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  • Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)

Abstract

The invention provides a medicinal dressing and a preparation method thereof. The medicinal dressing is prepared according to the following steps: (1) mixing and stirring hydroxyethyl cellulose, carboxymethyl cellulose, sodium hydroxide and distilled water; (2) performing filtration, performing mixing with absolute ethyl alcohol, and performing stirring by virtue of a magnetic stirrer; (3) performing filtration, and performing washing for three times by virtue of absolute ethyl alcohol; (4) performing drying in a drying oven; (5) performing mixing and stirring with ascorbyl palmitate, sodium alginate, xanthan gum, sodium dehydroacetate, chitosan, polysaccharides of peuraria, chloroacetic acid, glycerin and surplus distilled water; (6) pouring the product into a die for standing still and defoaming; (7) pre-freezing the product at temperature of -60 DEG C in a refrigerator; (8) performing freeze-drying in a freeze dryer to obtain the medicinal dressing. The medicinal dressing has good water absorption effects and high water retention, and also has certain pressure resistance.

Description

A kind of medicinal dressing and preparation method thereof
Technical field
The present invention relates to medical material field, be specifically related to a kind of medicinal dressing and preparation method thereof.
Background technology
Skin is the organ that human body is maximum, is made up of epidermis, corium and subcutaneous tissue etc., and containing accessory organ and blood vessel, lymphatic vessel and nerve etc..Skin can avoid the forfeiture of machine internal water and electrolyte; protection body is from the radiation in external environment and the directly harm of chemical substance, antibacterial and virus; the balance of internal water and other material can be regulated simultaneously, there is regulation body temperature the effect of perception external information.The skin injury caused due to these exopathogenic factors such as wound, burn, if be not acted upon, can cause a series of problem to body, even can cause life danger time serious.Therefore, when skin sustains damage, wound should be carried out protection timely and effectively and process, prevent wound surface to be infected and body is caused secondary injury.For injured human body; in the case of the normal physiological function of skin is destroyed; medical dressing can protect human body; it is avoided to be subject to more macrolesion; before skin reconstruction or recovery; the wound-surface cover of one function admirable can temporarily play the partial action of skin barrier function, provides a favourable microenvironment for wound healing, waits wound surface epithelization or is transitioned into the permanent skin barrier of reconstruction.Progress along with science and technology, various medical dressing arise at the historic moment, and preferably medical dressing should be able to absorb wound fluid, transudate is made to obtain abundant drain, there is again good water-retaining property, transudate can be all or partially held in covering, thus it is being partially formed a moistening microenvironment, owing to propagation and the epithelial cell of cell have been moved facilitation by moistening substrate, epithelial cell can be carried out to the mobile of wound surface rapidly from healthy skin, the healing of wound can be accelerated, therefore, research and development water absorption and the best medical dressing of water-retaining property have great importance and wide market prospect.
Summary of the invention
Solve the technical problem that:It is an object of the invention to provide a kind of medicinal dressing, have good soaking effect and water-retaining property, this material also has certain anti-pressure ability simultaneously.
Technical scheme:A kind of medicinal dressing, is prepared from weight portion by following component: hydroxyethyl cellulose 20-40 part, carboxymethyl cellulose 15-25 part, ascorbyl palmitate 0.2-0.4 part, sodium alginate 3-7 part, xanthan gum 1-3 part, dehydroactic acid sodium 0.1-0.2 part, chitosan 2-5 part, pueraria polysaccharide 0.1-0.3 part, monoxone 2-4 part, sodium hydroxide 5-10 part, glycerol 1-2 part, dehydrated alcohol 40-60 part, distilled water 150-300 part.
Further preferred, described a kind of medicinal dressing, is prepared from weight portion by following component: hydroxyethyl cellulose 25-35 part, carboxymethyl cellulose 17-23 part, ascorbyl palmitate 0.25-0.35 part, sodium alginate 4-6 part, xanthan gum 1.5-2.5 part, dehydroactic acid sodium 0.11-0.16 part, chitosan 3-4 part, pueraria polysaccharide 0.15-0.25 part, monoxone 2.5-3.5 part, sodium hydroxide 6-9 part, glycerol 1.3-1.7 part, dehydrated alcohol 45-55 part, distilled water 200-250 part.
The preparation method of above-mentioned degradable packaging material comprises the following steps:
(1) by hydroxyethyl cellulose, carboxymethyl cellulose, sodium hydroxide and 50-100 part distilled water mix and blend 20-40 minute;(2) Filter, and dehydrated alcohol mixing, stir 60-80 minute with magnetic stirrer;
(3) filter, with absolute ethanol washing 3 times;
(4) put in baking oven, dry at temperature 40-60 DEG C;
(5) mix with ascorbyl palmitate, sodium alginate, xanthan gum, dehydroactic acid sodium, chitosan, pueraria polysaccharide, monoxone, glycerol, residue distilled water, at temperature 60-65 DEG C, be stirred 30-50 minute;
(6) pour in mould, standing and defoaming;
(7) put in refrigerator, at temperature-60 DEG C, carry out pre-freeze 7-8 hour;
(8) putting into and carry out lyophilization in freezer dryer and get final product, temperature is-60 ~-50 DEG C, and pressure is 20-25Pa, and drying time is 48-50 hour.
It is further preferred that mixing time is 25-35 minute in step (1).
It is further preferred that mixing time is 65-75 minute in step (2).
It is further preferred that temperature is 45-55 DEG C in step (4).
It is further preferred that temperature is 61-64 DEG C in step (5), mixing time is 35-45 minute.
It is further preferred that in step (7) the pre-freeze time be 7.5 hours.
It is further preferred that temperature is-55 DEG C in step (8), pressure is 21-24Pa, and drying time is 49 hours.
Beneficial effect:A kind of medicinal dressing of the present invention has good soaking effect and water-retaining property; its water absorption is up to 12.61g/g; moisture-holding capacity is 7.41g/g; it is a significant benefit to the healing of wound; this material also has certain anti-pressure ability simultaneously; its comprcssive strength is 0.095MPa, can be effectively protected wound in extraneous touching.
Detailed description of the invention
Embodiment 1
A kind of medicinal dressing, is prepared from weight portion by following component: hydroxyethyl cellulose 20 parts, carboxymethyl cellulose 15 parts, ascorbyl palmitate 0.2 part, sodium alginate 3 parts, xanthan gum 1 part, 0.1 part of dehydroactic acid sodium, chitosan 2 parts, pueraria polysaccharide 0.1 part, monoxone 2 parts, sodium hydroxide 5 parts, glycerol 1 part, dehydrated alcohol 40 parts, distilled water 150 parts.
The preparation method of above-mentioned degradable packaging material is:
(1) by hydroxyethyl cellulose, carboxymethyl cellulose, sodium hydroxide and 50 parts of distilled water mix and blends 20 minutes;
(2) filter, and dehydrated alcohol mixing, stir 60 minutes with magnetic stirrer;
(3) filter, with absolute ethanol washing 3 times;
(4) put in baking oven, dry at temperature 40 DEG C;
(5) mix with ascorbyl palmitate, sodium alginate, xanthan gum, dehydroactic acid sodium, chitosan, pueraria polysaccharide, monoxone, glycerol, residue distilled water, under temperature 60 C, be stirred 30 minutes;
(6) pour in mould, standing and defoaming;
(7) put in refrigerator, at temperature-60 DEG C, carry out pre-freeze 7 hours;
(8) putting into and carry out lyophilization in freezer dryer and get final product, temperature is-60 DEG C, and pressure is 20Pa, and drying time is 48 hours.
Embodiment 2
A kind of medicinal dressing, is prepared from weight portion by following component: hydroxyethyl cellulose 25 parts, carboxymethyl cellulose 17 parts, ascorbyl palmitate 0.25 part, sodium alginate 4 parts, xanthan gum 1.5 parts, 0.11 part of dehydroactic acid sodium, chitosan 3 parts, pueraria polysaccharide 0.15 part, monoxone 2.5 parts, sodium hydroxide 6 parts, glycerol 1.3 parts, dehydrated alcohol 45 parts, distilled water 200 parts.
The preparation method of above-mentioned degradable packaging material is:
(1) by hydroxyethyl cellulose, carboxymethyl cellulose, sodium hydroxide and 60 parts of distilled water mix and blends 25 minutes;
(2) filter, and dehydrated alcohol mixing, stir 65 minutes with magnetic stirrer;
(3) filter, with absolute ethanol washing 3 times;
(4) put in baking oven, dry under temperature 45 C;
(5) mix with ascorbyl palmitate, sodium alginate, xanthan gum, dehydroactic acid sodium, chitosan, pueraria polysaccharide, monoxone, glycerol, residue distilled water, at temperature 61 DEG C, be stirred 35 minutes;
(6) pour in mould, standing and defoaming;
(7) put in refrigerator, at temperature-60 DEG C, carry out pre-freeze 7.5 hours;
(8) putting into and carry out lyophilization in freezer dryer and get final product, temperature is-55 DEG C, and pressure is 21Pa, and drying time is 49 hours.
Embodiment 3
A kind of medicinal dressing, is prepared from weight portion by following component: hydroxyethyl cellulose 30 parts, carboxymethyl cellulose 20 parts, ascorbyl palmitate 0.3 part, sodium alginate 5 parts, xanthan gum 2 parts, 0.15 part of dehydroactic acid sodium, chitosan 3.5 parts, pueraria polysaccharide 0.2 part, monoxone 3 parts, sodium hydroxide 7.5 parts, glycerol 1.5 parts, dehydrated alcohol 50 parts, distilled water 225 parts.
The preparation method of above-mentioned degradable packaging material is:
(1) by hydroxyethyl cellulose, carboxymethyl cellulose, sodium hydroxide and 75 parts of distilled water mix and blends 30 minutes;(2) Filter, and dehydrated alcohol mixing, stir 70 minutes with magnetic stirrer;
(3) filter, with absolute ethanol washing 3 times;
(4) put in baking oven, dry under temperature 50 C;
(5) mix with ascorbyl palmitate, sodium alginate, xanthan gum, dehydroactic acid sodium, chitosan, pueraria polysaccharide, monoxone, glycerol, residue distilled water, at temperature 62 DEG C, be stirred 40 minutes;
(6) pour in mould, standing and defoaming;
(7) put in refrigerator, at temperature-60 DEG C, carry out pre-freeze 7.5 hours;
(8) putting into and carry out lyophilization in freezer dryer and get final product, temperature is-55 DEG C, and pressure is 22Pa, and drying time is 49 hours.
Embodiment 4
A kind of medicinal dressing, is prepared from weight portion by following component: hydroxyethyl cellulose 35 parts, carboxymethyl cellulose 23 parts, ascorbyl palmitate 0.35 part, sodium alginate 6 parts, xanthan gum 2.5 parts, 0.16 part of dehydroactic acid sodium, chitosan 4 parts, pueraria polysaccharide 0.25 part, monoxone 3.5 parts, sodium hydroxide 9 parts, glycerol 1.7 parts, dehydrated alcohol 55 parts, distilled water 250 parts.
The preparation method of above-mentioned degradable packaging material is:
(1) by hydroxyethyl cellulose, carboxymethyl cellulose, sodium hydroxide and 90 parts of distilled water mix and blends 35 minutes;
(2) filter, and dehydrated alcohol mixing, stir 75 minutes with magnetic stirrer;
(3) filter, with absolute ethanol washing 3 times;
(4) put in baking oven, dry at temperature 55 DEG C;
(5) mix with ascorbyl palmitate, sodium alginate, xanthan gum, dehydroactic acid sodium, chitosan, pueraria polysaccharide, monoxone, glycerol, residue distilled water, at temperature 64 DEG C, be stirred 45 minutes;
(6) pour in mould, standing and defoaming;
(7) put in refrigerator, at temperature-60 DEG C, carry out pre-freeze 7.5 hours;
(8) putting into and carry out lyophilization in freezer dryer and get final product, temperature is-55 DEG C, and pressure is 24Pa, and drying time is 49 hours.
Embodiment 5
A kind of medicinal dressing, is prepared from weight portion by following component: hydroxyethyl cellulose 40 parts, carboxymethyl cellulose 25 parts, ascorbyl palmitate 0.4 part, sodium alginate 7 parts, xanthan gum 3 parts, 0.2 part of dehydroactic acid sodium, chitosan 5 parts, pueraria polysaccharide 0.3 part, monoxone 4 parts, sodium hydroxide 10 parts, glycerol 2 parts, dehydrated alcohol 60 parts, distilled water 300 parts.
The preparation method of above-mentioned degradable packaging material is:
(1) by hydroxyethyl cellulose, carboxymethyl cellulose, sodium hydroxide and 100 parts of distilled water mix and blends 40 minutes;(2) Filter, and dehydrated alcohol mixing, stir 80 minutes with magnetic stirrer;
(3) filter, with absolute ethanol washing 3 times;
(4) put in baking oven, dry under temperature 60 C;
(5) mix with ascorbyl palmitate, sodium alginate, xanthan gum, dehydroactic acid sodium, chitosan, pueraria polysaccharide, monoxone, glycerol, residue distilled water, at temperature 65 DEG C, be stirred 50 minutes;
(6) pour in mould, standing and defoaming;
(7) put in refrigerator, at temperature-60 DEG C, carry out pre-freeze 8 hours;
(8) putting into and carry out lyophilization in freezer dryer and get final product, temperature is-50 DEG C, and pressure is 25Pa, and drying time is 50 hours.
Comparative example 1
The present embodiment is to replace carboxymethyl cellulose with hydroxyethyl cellulose with the difference of embodiment 5.Specifically:
A kind of medicinal dressing, is prepared from weight portion by following component: hydroxyethyl cellulose 65 parts, ascorbyl palmitate 0.4 part, sodium alginate 7 parts, xanthan gum 3 parts, 0.2 part of dehydroactic acid sodium, chitosan 5 parts, pueraria polysaccharide 0.3 part, monoxone 4 parts, sodium hydroxide 10 parts, glycerol 2 parts, dehydrated alcohol 60 parts, distilled water 300 parts.
The preparation method of above-mentioned degradable packaging material is:
(1) by hydroxyethyl cellulose, sodium hydroxide and 100 parts of distilled water mix and blends 40 minutes;(2) Filter, and dehydrated alcohol mixing, stir 80 minutes with magnetic stirrer;
(3) filter, with absolute ethanol washing 3 times;
(4) put in baking oven, dry under temperature 60 C;
(5) mix with ascorbyl palmitate, sodium alginate, xanthan gum, dehydroactic acid sodium, chitosan, pueraria polysaccharide, monoxone, glycerol, residue distilled water, at temperature 65 DEG C, be stirred 50 minutes;
(6) pour in mould, standing and defoaming;
(7) put in refrigerator, at temperature-60 DEG C, carry out pre-freeze 8 hours;
(8) putting into and carry out lyophilization in freezer dryer and get final product, temperature is-50 DEG C, and pressure is 25Pa, and drying time is 50 hours.
Comparative example 2
The present embodiment is to replace xanthan gum with sodium alginate with the difference of embodiment 5.Specifically:
A kind of medicinal dressing, is prepared from weight portion by following component: hydroxyethyl cellulose 40 parts, carboxymethyl cellulose 25 parts, ascorbyl palmitate 0.4 part, sodium alginate 10 parts, 0.2 part of dehydroactic acid sodium, chitosan 5 parts, pueraria polysaccharide 0.3 part, monoxone 4 parts, sodium hydroxide 10 parts, glycerol 2 parts, dehydrated alcohol 60 parts, distilled water 300 parts.
The preparation method of above-mentioned degradable packaging material is:
(1) by hydroxyethyl cellulose, carboxymethyl cellulose, sodium hydroxide and 100 parts of distilled water mix and blends 40 minutes;(2) Filter, and dehydrated alcohol mixing, stir 80 minutes with magnetic stirrer;
(3) filter, with absolute ethanol washing 3 times;
(4) put in baking oven, dry under temperature 60 C;
(5) mix with ascorbyl palmitate, sodium alginate, dehydroactic acid sodium, chitosan, pueraria polysaccharide, monoxone, glycerol, residue distilled water, at temperature 65 DEG C, be stirred 50 minutes;
(6) pour in mould, standing and defoaming;
(7) put in refrigerator, at temperature-60 DEG C, carry out pre-freeze 8 hours;
(8) putting into and carry out lyophilization in freezer dryer and get final product, temperature is-50 DEG C, and pressure is 25Pa, and drying time is 50 hours.
Table 1 below is embodiment and the partial properties index of comparative example of material of the present invention, it may be seen that, the present invention has good soaking effect and water-retaining property, its water absorption is up to 12.61g/g, moisture-holding capacity is 7.41g/g, this material also has certain anti-pressure ability simultaneously, and its comprcssive strength is 0.095MPa.
The partial properties index of table 1 medicinal dressing
Embodiment 1 Embodiment 2 Embodiment 3 Embodiment 4 Embodiment 5 Comparative example 1 Comparative example 2
Water absorption (g/g) 12.52 12.54 12.57 12.61 12.55 11.88 11.75
Moisture-holding capacity (g/g) 7.24 7.28 7.34 7.41 7.37 6.33 5.46
Comprcssive strength (MPa) 0.092 0.093 0.094 0.095 0.094 0.081 0.088

Claims (9)

1. a medicinal dressing, it is characterised in that: it is prepared from weight portion by following component: hydroxyethyl cellulose 20-40 part, carboxymethyl cellulose 15-25 part, ascorbyl palmitate 0.2-0.4 part, sodium alginate 3-7 part, xanthan gum 1-3 part, dehydroactic acid sodium 0.1-0.2 part, chitosan 2-5 part, pueraria polysaccharide 0.1-0.3 part, monoxone 2-4 part, sodium hydroxide 5-10 part, glycerol 1-2 part, dehydrated alcohol 40-60 part, distilled water 150-300 part.
A kind of medicinal dressing the most according to claim 1, it is characterised in that: it is prepared from weight portion by following component: hydroxyethyl cellulose 25-35 part, carboxymethyl cellulose 17-23 part, ascorbyl palmitate 0.25-0.35 part, sodium alginate 4-6 part, xanthan gum 1.5-2.5 part, dehydroactic acid sodium 0.11-0.16 part, chitosan 3-4 part, pueraria polysaccharide 0.15-0.25 part, monoxone 2.5-3.5 part, sodium hydroxide 6-9 part, glycerol 1.3-1.7 part, dehydrated alcohol 45-55 part, distilled water 200-250 part.
3. the preparation method of a kind of medicinal dressing described in any one of claim 1 to 2, it is characterised in that: comprise the following steps:
(1) by hydroxyethyl cellulose, carboxymethyl cellulose, sodium hydroxide and 50-100 part distilled water mix and blend 20-40 minute;(2) Filter, and dehydrated alcohol mixing, stir 60-80 minute with magnetic stirrer;
(3) filter, with absolute ethanol washing 3 times;
(4) put in baking oven, dry at temperature 40-60 DEG C;
(5) mix with ascorbyl palmitate, sodium alginate, xanthan gum, dehydroactic acid sodium, chitosan, pueraria polysaccharide, monoxone, glycerol, residue distilled water, at temperature 60-65 DEG C, be stirred 30-50 minute;
(6) pour in mould, standing and defoaming;
(7) put in refrigerator, at temperature-60 DEG C, carry out pre-freeze 7-8 hour;
(8) putting into and carry out lyophilization in freezer dryer and get final product, temperature is-60 ~-50 DEG C, and pressure is 20-25Pa, and drying time is 48-50 hour.
The preparation method of a kind of medicinal dressing the most according to claim 3, it is characterised in that: in described step (1), mixing time is 25-35 minute.
The preparation method of a kind of medicinal dressing the most according to claim 3, it is characterised in that: in described step (2), mixing time is 65-75 minute.
The preparation method of a kind of medicinal dressing the most according to claim 3, it is characterised in that: in described step (4), temperature is 45-55 DEG C.
The preparation method of a kind of medicinal dressing the most according to claim 3, it is characterised in that: in described step (5), temperature is 61-64 DEG C, and mixing time is 35-45 minute.
The preparation method of a kind of medicinal dressing the most according to claim 3, it is characterised in that: in described step (7), the pre-freeze time is 7.5 hours.
The preparation method of a kind of medicinal dressing the most according to claim 3, it is characterised in that: in described step (8), temperature is-55 DEG C, and pressure is 21-24Pa, and drying time is 49 hours.
CN201610471317.2A 2016-06-27 2016-06-27 Medicinal dressing and preparation method thereof Pending CN105963756A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108309823A (en) * 2018-03-22 2018-07-24 徐增强 A kind of baby talcum powder and preparation method thereof

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Publication number Priority date Publication date Assignee Title
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WO2016005700A1 (en) * 2014-07-11 2016-01-14 Celenys Method for modifying polysaccharides by grafting polyetheramines, polysaccharides thus modified and preparations comprising same and having heat-sensitive rheological properties

Patent Citations (3)

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Publication number Priority date Publication date Assignee Title
CN103083713A (en) * 2012-12-10 2013-05-08 江苏华亿细胞组织工程有限公司 Sterile polymerized covering dressing for wound surface
WO2016005700A1 (en) * 2014-07-11 2016-01-14 Celenys Method for modifying polysaccharides by grafting polyetheramines, polysaccharides thus modified and preparations comprising same and having heat-sensitive rheological properties
CN104622897A (en) * 2015-03-04 2015-05-20 中英阿诺康(宁夏)生物科技有限公司 Skin moisturizer for treating skin disease and preparation method of skin moisturizer

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108309823A (en) * 2018-03-22 2018-07-24 徐增强 A kind of baby talcum powder and preparation method thereof

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Application publication date: 20160928