CN107029272A - A kind of alginate medical dressing and preparation method thereof - Google Patents
A kind of alginate medical dressing and preparation method thereof Download PDFInfo
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- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/18—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
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- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
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- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/106—Halogens or compounds thereof, e.g. iodine, chlorite
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/204—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with nitrogen-containing functional groups, e.g. aminoxides, nitriles, guanidines
- A61L2300/206—Biguanides, e.g. chlorohexidine
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
- A61L2300/414—Growth factors
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Abstract
The present invention relates to field of medical article technology, and in particular to a kind of alginate medical dressing and preparation method thereof.The medical dressing, is made by alginate fiber is immersed in feature soak；Wherein feature soak is made up of the raw material of following weight percent consumption：Carboxymethyl chitosan 2~4%, chitosan oligosaccharide 1~2%, chitosan hydrochloride 3~6%, hyaluronic acid-like chitosan 1~2%, antiseptic 0.03~0.05%, sodium carboxymethylcellulose 0.5~5%, calcium chloride 1~6%, epithelical cell growth factor 0.005~0.05%, aloe extract 0.02~0.05%, surplus are water.Loading chitosan class material, antiseptic, carboxymethyl cellulose, calcium chloride, epithelical cell growth factor and aloe extract in alginate fiber, assign the significant antibacterial of product, functions of stanching and promoting healing, the wound that prevents adhesion, the effect for preventing scar.
Description
Technical field
The present invention relates to field of medical article technology, and in particular to a kind of alginate medical dressing and preparation method thereof.
Background technology
Skin is the vitals of human body, and human body is shielded.Skin injury can cause a series of problem of body,
Such as bacterium infection, metabolism aggravation, moisture and protein are excessively lost in, endocrine and immune system dysfunction etc., sternly
The possibility threat to life of weight.Therefore, after skin injury, wound is generally protected using medical dressing, trauma surface infestation is prevented and tight
It is dehydrated that there is provided the wet environment for being conducive to wound healing, wound healing again.
Alginate is main Natural linear polysaccharide, nontoxic, biodegradable, the bio-compatible extracted from brown alga of a class
Property it is high, the high-hygroscopicity and gelation of alginate make it be widely used in terms of Morden wound dressing.Such as China
It is selected from patent 200680051180.X antiseptic alginate preparations, said preparation comprising at least one alginate and at least one
Antibacterial substance in group including Biguanide derivative, Win-41464 and Taurolidine；But the antiseptic alginate preparation
Function is single, only contains antimicrobial component, and absorption sepage is limited in one's ability, and no antisticking component, auxiliary material is easy to adhesion wound, is not easy to more
Change.Chinese patent 201110366674X discloses a kind of Silver-loaded alginate fiber and preparation method thereof, discloses by dipping
Mode loading nano silvery on alginic acid fibre, and washed using organic solvent, being made has good bulkiness and strength
The alginic acid fibre of bactericidal effect；But the alginic acid fibre easily causes organic solvent residual through organic solvent washing, there is life
The risk of thing compatibility, it is safe to the human body to have larger hidden danger, and function is single, only contains antimicrobial component, absorbs sepage energy
Effectively, no antisticking component, auxiliary material is easy to adhesion wound to power, is not easy to change.Chinese patent 201510055030.7 discloses one
The preparation method of high antibiotic property alginates auxiliary material is planted, is grafted after being activated by using organic solvent to alginate fibre surface
Quaternizing agent improves the anti-microbial property of alginates, but the absorption sepage of the auxiliary material is limited in one's ability, and function is single, and prepares
During used the toxic reagents such as methanol, acetone, hydrogen peroxide, iron ammonium sulfate, not to product carry out biocompatibility detection,
There is larger potential safety hazard to human body.Chinese patent CN201510402076.1 discloses a kind of algae containing compound silver-colored zinc antiseptic
Hydrochlorate dressing and preparation method thereof, the dressing improves its antibacterial and therapeutic effect by adding compound silver-colored zinc antiseptic, but its
Absorb that sepage is limited in one's ability, function is single, without the composition that prevents adhesion, it is easy to and surface of a wound adhesion, and increase dressing is difficult, to patient with
Carry out secondary damage.
Chitosan is the natural material for being widely used in biomedical sector, is cured with antibacterial, moisture absorption, rush blood coagulation, rush
The polycation polysaccharide of the functions such as conjunction, analgesia.Occur in that chitosan is applied in alginate dressing by some in recent years, as in
State's patent 201210020699.9 discloses a kind of alginate antibacterial dressing and its preparation method and preparation method thereof, by by soluble alginic acid
Spinning solution is made in salt, water-solubility chitosan derivative or water-solubility chitin derivative, while adding silver system in coagulating bath
Antiseptic, spinning obtains blended fiber product, and alginate antibacterial dressing and its preparation method is further made, and with sterilization, promotes wound healing
Effect, but the dressing is without preventing adhesion composition, it is easy to and surface of a wound adhesion, and increase dressing is difficult, and secondary damage is brought to patient
Wound.As Chinese patent 201410340635.6 discloses sodium alginate-sodium carboxymethylcellulose-Chitosan in Wound Dressing and its system
Preparation Method, the component of the dressing, which is made, sodium alginate, sodium carboxymethylcellulose, chitosan, glycerine and calcium chloride, but this is applied
Expect to act on the promoting healing of wound and prevent effect of scar from can not meet clinical practice.
The content of the invention
In order to overcome defect of the prior art, it is an object of the invention to provide a kind of alginate medical dressing, this is applied
Material has effects that significant antibacterial, promoting healing, anti-scar and prevented adhesion.
Meanwhile, the present invention also aims to provide a kind of preparation method of alginate medical dressing.
In order to realize the above object the technical solution adopted in the present invention is：
A kind of alginate medical dressing, is prepared from by alginate fiber is immersed in feature soak；Its
Middle feature soak is prepared from by the raw material of following weight percent consumption：Carboxymethyl chitosan 2~4%, chitosan oligosaccharide 1~
2%th, chitosan hydrochloride 3~6%, hyaluronic acid-like chitosan 1~2%, antiseptic 0.03~0.05%, carboxymethyl cellulose
Sodium 0.5~5%, calcium chloride 1~6%, epithelical cell growth factor 0.005~0.05%, aloe extract 0.02~0.05%,
Surplus is water.
Optionally, the quality usage ratio of the alginate fiber and feature soak is 1:10~1:50.
Optionally, the antiseptic is guanidinesalt class antiseptic and/or silver-series antibacterial agent.
Optionally, the guanidinesalt class antiseptic is hexamethylene.
Optionally, the silver-series antibacterial agent is nano phase ag_2 o.
Optionally, the alginate is high G types alginate.
The preparation method of above-mentioned alginate medical dressing, including following operating procedure：
1) take carboxymethyl chitosan, chitosan oligosaccharide, chitosan hydrochloride, hyaluronic acid-like chitosan, antiseptic, carboxymethyl fine
The plain sodium of dimension, calcium chloride, epithelical cell growth factor, aloe extract are added to the water, and are well mixed, obtain feature soak；
2) alginate fiber is taken to immerse step 1) in the soak for preparing, soak 2~10 hours, take out alginate fine
Dimension, freezes, irradiates, produce described alginate medical dressing.
Alginate medical dressing of the present invention, loading chitosan class material, antiseptic, carboxymethyl in alginate fiber
Cellulose, calcium chloride, epithelical cell growth factor and aloe extract, assign product significant antibacterial, functions of stanching and promoting healing, anti-sticking
Connect wound, prevent effect of scar, be specially：
A variety of chitosan class material compounding uses, carboxymethyl chitosan, chitosan hydrochloride have the work of antibacterial anti-infection
With, acted synergistically with antiseptic, antibacterial anti-infection effect of lifting product；What chitosan oligosaccharide and hyaluronic acid-like chitosan had had
Moisture retention, alginate fiber forms gel state after absorbing sepage, prevents wound adhesion, is acted synergistically with carboxymethyl cellulose,
While the ability of product absorption sepage is lifted, protection wound is in suitable humidity environment, promotes the healing of wound；Shell gathers
Sugared hydrochloride is the chitosan derivatives with strong cation, promotes body fight microbial inoculum, epithelical cell growth factor and reed
Absorbing for functional drug ingedient such as luxuriant growth extract, lifts product antibacterial, promoting healing, the effect for preventing scar from producing,
And it can be acted synergistically with calcium chloride, lift the hemostasia effect of product；Chitosan oligosaccharide has good complexing to calcium ion,
Calcium chloride can be promoted to be supported on alginate fiber, the hemostasia effect of product be lifted, while chitosan oligosaccharide can also activate base
Body cell, prevents cell senescence, is acted synergistically with EGF, aloe extract, and lifting product prevents scar formation
Effect.
Embodiment
Technical scheme is described in detail below by specific embodiment.
Following alginates are high G types alginate.
Embodiment 1
A kind of alginate medical dressing, is prepared from by alginate fiber is immersed in feature soak；Its
Middle feature soak is prepared from by the raw material of following weight percent consumption：Carboxymethyl chitosan 3%, chitosan oligosaccharide 1.5%, shell
Glycan hydrochloride 5%, hyaluronic acid-like chitosan 1.5%, antiseptic 0.04%, sodium carboxymethylcellulose 3%, calcium chloride 3%,
Epithelical cell growth factor 0.03%, aloe extract 0.04%, surplus are water；Wherein alginate fiber soaks with feature
The quality usage ratio of liquid is 1：30.
The preparation method of above-mentioned alginate medical dressing, including following operating procedure：
1) take carboxymethyl chitosan, chitosan oligosaccharide, chitosan hydrochloride, hyaluronic acid-like chitosan, antiseptic, carboxymethyl fine
The plain sodium of dimension, calcium chloride, epithelical cell growth factor, aloe extract are added to the water, and are well mixed, obtain feature soak；
2) take alginate fiber immerse step 1) prepare soak in, soak 6 hours, take out alginate fiber,
Lyophilized, irradiation, produces described alginate medical dressing.
Embodiment 2
A kind of alginate medical dressing, is prepared from by alginate fiber is immersed in feature soak；Its
Middle feature soak is prepared from by the raw material of following weight percent consumption：Wherein feature soak is by following weight percent
The raw material of consumption is prepared from：Carboxymethyl chitosan 2%, chitosan oligosaccharide 1%, chitosan hydrochloride 3%, hyaluronic acid-like chitosan
1%th, antiseptic 0.03, sodium carboxymethylcellulose 0.5%, calcium chloride 1%, epithelical cell growth factor 0.005%, aloe are extracted
Thing 0.02%, surplus are water；The quality usage ratio of wherein alginate fiber and feature soak is 1：50.
The preparation method of above-mentioned alginate medical dressing, including following operating procedure：
1) take carboxymethyl chitosan, chitosan oligosaccharide, chitosan hydrochloride, hyaluronic acid-like chitosan, antiseptic, carboxymethyl fine
The plain sodium of dimension, calcium chloride, epithelical cell growth factor, aloe extract are added to the water, and are well mixed, obtain feature soak；
2) take alginate fiber immerse step 1) prepare soak in, soak 2 hours, take out alginate fiber,
Lyophilized, irradiation, produces described alginate medical dressing.
Embodiment 3
A kind of alginate medical dressing, is prepared from by alginate fiber is immersed in feature soak；Its
Middle feature soak is prepared from by the raw material of following weight percent consumption：Wherein feature soak is by following weight percent
The raw material of consumption is prepared from：Carboxymethyl chitosan 4%, chitosan oligosaccharide 2%, chitosan hydrochloride 6%, hyaluronic acid-like chitosan
2%th, antiseptic 0.05%, sodium carboxymethylcellulose 5%, calcium chloride 6%, epithelical cell growth factor 0.05%, aloe are extracted
Thing 0.05%, surplus are water；The quality usage ratio of wherein alginate fiber and feature soak is 1：10.
The preparation method of above-mentioned alginate medical dressing, including following operating procedure：
1) take carboxymethyl chitosan, chitosan oligosaccharide, chitosan hydrochloride, hyaluronic acid-like chitosan, antiseptic, carboxymethyl fine
The plain sodium of dimension, calcium chloride, epithelical cell growth factor, aloe extract are added to the water, and are well mixed, obtain feature soak；
2) take alginate fiber immerse step 1) prepare soak in, soak 10 hours, take out alginate fiber,
Lyophilized, irradiation, produces described alginate medical dressing.
Comparative example 1
This comparative example alginate medical dressing, as different from Example 1, in this comparative example feature immersion formula of liquid
Carboxymethyl chitosan, chitosan oligosaccharide, chitosan hydrochloride, hyaluronic acid-like chitosan are saved, chitosan 11% is added；Other are with real
Apply example 1.
Comparative example 2
This comparative example alginate medical dressing, as different from Example 1, saves chitosan hydrochloride, adjustment class is saturating
The consumption of the sour chitosan of bright matter is 6.5%；Other be the same as Examples 1.
Comparative example 3
This comparative example alginate medical dressing, as different from Example 1, saves aloe extract, adjustment epidermis life
The consumption of the long factor is 0.07%；Other be the same as Examples 1.
Comparative example 4
This comparative example alginate medical dressing, as different from Example 1, saves EGF, adjusts aloe
The consumption of extract is 0.07%；Other be the same as Examples 1.
Test example
1st, test model is set up：Choose upgrowth situation 7 test pigs of identical, quality be 18~22kg, labeled as A, B,
After C, D, E, F, G, 3% yellow Jackets, 30mg/kg Intravenous Anesthesias, back preserved skin, frame of causing injury is fixed in prone position, be 3cm ×
5cm wound indicia framings, at every 8,0.9% physiological saline, which is subcutaneously injected, swells it, mouth of being caused injury with dermatotome, in corium and flesh
Between meat, with operation to muscle is scratched on wound, with field sludge pollution wound；
2nd, test method：The alginate medical dressing that A test pigs are prepared in wound application embodiment 1；B test pigs exist
Alginate medical dressing prepared by wound application embodiment 2；The marine alga that C test pigs are prepared in wound application embodiment 3
Hydrochlorate medical dressing；The alginate medical dressing E test pigs that D test pigs are prepared in wound application comparative example 1 are in wound
Alginate medical dressing prepared by application comparative example 2；The alginate doctor that F test pigs are prepared in wound application comparative example 3
Use dressing；The alginate medical dressing that G test pigs are prepared in wound application comparative example 4；Statistics wound is before dressing respectively
And the clump count of 24 hours after dressing；Observe during the healing state of each test pig wound, dressing healing of wound every 3 days more
Change once；As a result it is as shown in table 1 below；
3rd, clump count method of counting：Sterile saline 0.5h is immersed in aseptic filter paper, 4 layers are stacked with sterile tweezer
Filter paper is placed on after the wound 5min of pig back, is removed and is placed in 5ml sterile saline test tubes, takes liquid to be diluted to 10 respectively-1、
10-2、10-3、10-4, last 3 concentration takes 100 μ l bacterium solutions to be applied on agar plate, is placed in 37 DEG C of incubators and cultivates 24 respectively
Hour, calculate average colony number.
Table 1
From the data shown in above-mentioned table 1, the anti-microbial property of embodiment 1 and the dressing of embodiment 3 is better than embodiment 2, table
The anti-microbial property of the bright dressing for using hexamethylene to be prepared as antiseptic be better than using nano phase ag_2 o as
Dressing prepared by antiseptic；Embodiment 1 prepare dressing anti-microbial property, promote wound healing performance and prevent scar from producing
Performance be superior to comparative example 1~4 and show, the present invention is transparent using carboxymethyl chitosan, chitosan oligosaccharide, chitosan hydrochloride and class
Matter acid four kinds of chitosan derivatives compounding uses of chitosan, antibacterial, promotion wound healing, and combine stopping for calcium chloride promotion dressing
Blood function, further promotes wound healing in conjunction with EGF and aloe extract and prevents scar from producing.
Claims (6)
1. a kind of alginate medical dressing, it is characterised in that made by being immersed in alginate fiber in feature soak
It is standby to form；Wherein feature soak is prepared from by the raw material of following weight percent consumption：Carboxymethyl chitosan 2~4%, shell
Oligosaccharides 1~2%, chitosan hydrochloride 3~6%, hyaluronic acid-like chitosan 1~2%, antiseptic 0.03~0.05%, carboxylic first
Base sodium cellulosate 0.5~5%, calcium chloride 1~6%, epithelical cell growth factor 0.005~0.05%, aloe extract 0.02
~0.05%, surplus is water.
2. alginate medical dressing as claimed in claim 1, it is characterised in that the alginate fiber soaks with feature
The quality usage ratio for steeping liquid is 1:10~1:50.
3. alginate medical dressing as claimed in claim 1, it is characterised in that the antiseptic is guanidinesalt class antiseptic
And/or silver-series antibacterial agent.
4. alginate medical dressing as claimed in claim 3, it is characterised in that the guanidinesalt class antiseptic is poly- six methylene
Base biguanide hydrochloride.
5. alginate medical dressing as claimed in claim 3, it is characterised in that the silver-series antibacterial agent is nano oxidized
Silver.
6. a kind of preparation method of alginate medical dressing as claimed in claim 1, it is characterised in that including following operation
Step：
1) carboxymethyl chitosan, chitosan oligosaccharide, chitosan hydrochloride, hyaluronic acid-like chitosan, antiseptic, carboxymethyl cellulose are taken
Sodium, calcium chloride, epithelical cell growth factor, aloe extract are added to the water, and are well mixed, obtain feature soak；
2) take alginate fiber immerse step 1) prepare soak in, soak 2~10 hours, take out alginate fiber,
Lyophilized, irradiation, produces described alginate medical dressing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710229284.5A CN107029272B (en) | 2017-04-10 | 2017-04-10 | Alginate medical dressing and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710229284.5A CN107029272B (en) | 2017-04-10 | 2017-04-10 | Alginate medical dressing and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
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| CN107029272A true CN107029272A (en) | 2017-08-11 |
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| CN107469131A (en) * | 2017-08-29 | 2017-12-15 | 北京化工大学常州先进材料研究院 | A kind of calcium alginate biology based composite dressing for medical use and preparation method thereof |
| CN107617121A (en) * | 2017-10-13 | 2018-01-23 | 广州润虹医药科技股份有限公司 | A kind of skin wound biology induced activity dressing and its preparation method and application |
| CN109045356A (en) * | 2018-09-08 | 2018-12-21 | 佛山市森昂生物科技有限公司 | A kind of preparation method of active biological film tissue mending material |
| CN109234849A (en) * | 2018-09-05 | 2019-01-18 | 重庆爱阳生物科技有限公司 | A kind of medical ocean fiber of chitosan oligosaccharide and preparation method thereof |
| CN109453420A (en) * | 2018-11-29 | 2019-03-12 | 成都美益达医疗科技有限公司 | Hemostatic composition and its preparation method and application |
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| CN112494708A (en) * | 2019-09-16 | 2021-03-16 | 上海白衣缘生物工程有限公司 | Composite alginate medical dressing and preparation method thereof |
| CN112826975A (en) * | 2021-01-29 | 2021-05-25 | 河南亚都实业有限公司 | Medical chitosan rapid hemostatic dressing and preparation method thereof |
| CN112826987A (en) * | 2021-01-27 | 2021-05-25 | 青岛琛蓝海洋生物工程有限公司 | Anti-adhesion gel and preparation method thereof |
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| CN114588307A (en) * | 2022-04-08 | 2022-06-07 | 山东万容生物科技有限公司 | Alginate dressing and preparation method thereof |
| CN114870066A (en) * | 2022-04-21 | 2022-08-09 | 田耿家 | Functional dressing for treating chronic wound surface, preparation and preparation method thereof |
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| CN107469131A (en) * | 2017-08-29 | 2017-12-15 | 北京化工大学常州先进材料研究院 | A kind of calcium alginate biology based composite dressing for medical use and preparation method thereof |
| CN107617121B (en) * | 2017-10-13 | 2020-09-01 | 广州润虹医药科技股份有限公司 | Biological induction active dressing for skin wound surface and preparation method and application thereof |
| CN107617121A (en) * | 2017-10-13 | 2018-01-23 | 广州润虹医药科技股份有限公司 | A kind of skin wound biology induced activity dressing and its preparation method and application |
| CN109234849A (en) * | 2018-09-05 | 2019-01-18 | 重庆爱阳生物科技有限公司 | A kind of medical ocean fiber of chitosan oligosaccharide and preparation method thereof |
| CN109234849B (en) * | 2018-09-05 | 2021-04-09 | 重庆爱阳生物科技有限公司 | Chitosan oligosaccharide medical marine fiber and preparation method thereof |
| CN109045356A (en) * | 2018-09-08 | 2018-12-21 | 佛山市森昂生物科技有限公司 | A kind of preparation method of active biological film tissue mending material |
| CN109453420B (en) * | 2018-11-29 | 2021-01-08 | 成都美益达医疗科技有限公司 | Hemostatic composition, preparation method and application thereof |
| CN109453420A (en) * | 2018-11-29 | 2019-03-12 | 成都美益达医疗科技有限公司 | Hemostatic composition and its preparation method and application |
| CN109568635A (en) * | 2018-12-17 | 2019-04-05 | 河南省医疗器械检验所 | A kind of expansion in situ high-hydroscopicity hemostatic material and preparation method thereof |
| CN109568635B (en) * | 2018-12-17 | 2021-11-16 | 河南省医疗器械检验所 | In-situ expansion high-water-absorption hemostatic material and preparation method thereof |
| CN112494708A (en) * | 2019-09-16 | 2021-03-16 | 上海白衣缘生物工程有限公司 | Composite alginate medical dressing and preparation method thereof |
| CN110935056A (en) * | 2019-12-30 | 2020-03-31 | 山东星之诚生物科技有限公司 | Preparation method of alginate dressing with high hygroscopicity |
| CN111557790A (en) * | 2020-05-16 | 2020-08-21 | 江苏德鲁克生物科技有限公司 | Antibacterial and disinfectant nanofiber medical dressing |
| FR3110048A1 (en) * | 2020-05-18 | 2021-11-19 | Biolaffort | TREATMENT PROCESS FOR VINE WOOD DISEASES |
| CN112826987A (en) * | 2021-01-27 | 2021-05-25 | 青岛琛蓝海洋生物工程有限公司 | Anti-adhesion gel and preparation method thereof |
| CN112826975A (en) * | 2021-01-29 | 2021-05-25 | 河南亚都实业有限公司 | Medical chitosan rapid hemostatic dressing and preparation method thereof |
| CN113730283A (en) * | 2021-10-14 | 2021-12-03 | 扬州日兴生物科技股份有限公司 | Natural moisturizing and bacteriostatic facial mask containing compound functional chitosan |
| CN113846419A (en) * | 2021-10-14 | 2021-12-28 | 北京化工大学 | Antibacterial and disinfectant nanofiber medical dressing and preparation method thereof |
| CN113975447A (en) * | 2021-11-24 | 2022-01-28 | 四川大学 | Antibacterial alginate dressing and preparation method and application thereof |
| CN114569473A (en) * | 2022-02-10 | 2022-06-03 | 士露洁家化(武汉)有限公司 | Environment-friendly washing-free antibacterial gel and preparation method thereof |
| CN114569473B (en) * | 2022-02-10 | 2024-02-02 | 士露洁家化(武汉)有限公司 | Environment-friendly wash-free antibacterial gel and preparation method thereof |
| CN114588307A (en) * | 2022-04-08 | 2022-06-07 | 山东万容生物科技有限公司 | Alginate dressing and preparation method thereof |
| CN114588307B (en) * | 2022-04-08 | 2022-12-23 | 山东万容生物科技有限公司 | Alginate dressing and preparation method thereof |
| CN114870066A (en) * | 2022-04-21 | 2022-08-09 | 田耿家 | Functional dressing for treating chronic wound surface, preparation and preparation method thereof |
| CN115779131A (en) * | 2022-10-09 | 2023-03-14 | 湖南中腾湘岳生物科技有限公司 | Processing technology of medical dressing and medical dressing thereof |
| CN115779131B (en) * | 2022-10-09 | 2024-02-23 | 湖南中腾湘岳生物科技有限公司 | Processing technology of medical dressing and medical dressing thereof |
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Address after: 473000 West Section of Industrial Avenue in Industrial Agglomeration Area of Sheqi County, Nanyang City, Henan Province Patentee after: Henan Huibo Medical Co.,Ltd. Address before: 473000 Nanyang City, new energy economic and Technological Development Zone, Henan, the middle of the road in the middle of the ten Patentee before: Henan Huibo Medical Co.,Ltd. |