CN105938731B - 中子捕捉疗法装置 - Google Patents

中子捕捉疗法装置 Download PDF

Info

Publication number: CN105938731B
Authority: CN; China
Prior art keywords: boron; neutron; gamma; rays; concentration
Prior art date: 2015-03-05
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Active

Application number

CN201610118023.1A

Other languages

English (en)

Chinese (zh)

Other versions

CN105938731A (zh

Inventor

酒井文雄

田中浩基

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Sumitomo Heavy Industries Ltd

Kyoto University NUC

Original Assignee

Sumitomo Heavy Industries Ltd

Kyoto University NUC

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2015-03-05

Filing date

2016-03-02

Publication date

2018-03-30

2016-03-02 Application filed by Sumitomo Heavy Industries Ltd, Kyoto University NUC filed Critical Sumitomo Heavy Industries Ltd

2016-09-14 Publication of CN105938731A publication Critical patent/CN105938731A/zh

2018-03-30 Application granted granted Critical

2018-03-30 Publication of CN105938731B publication Critical patent/CN105938731B/zh

Status Active legal-status Critical Current

2036-03-02 Anticipated expiration legal-status Critical

Links

238000002560 therapeutic procedure Methods 0.000 title claims abstract description 48
ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical compound [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 claims abstract description 179
229910052796 boron Inorganic materials 0.000 claims abstract description 179
230000001678 irradiating effect Effects 0.000 claims abstract description 11
238000001514 detection method Methods 0.000 claims description 30
238000012360 testing method Methods 0.000 claims description 29
230000033228 biological regulation Effects 0.000 claims description 14
239000002245 particle Substances 0.000 description 29
206010028980 Neoplasm Diseases 0.000 description 8
239000003814 drug Substances 0.000 description 8
239000000463 material Substances 0.000 description 8
201000011510 cancer Diseases 0.000 description 6
239000008280 blood Substances 0.000 description 5
210000004369 blood Anatomy 0.000 description 5
238000005259 measurement Methods 0.000 description 5
230000005251 gamma ray Effects 0.000 description 4
230000005540 biological transmission Effects 0.000 description 3
239000003795 chemical substances by application Substances 0.000 description 3
230000002285 radioactive effect Effects 0.000 description 3
XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
238000010276 construction Methods 0.000 description 2
230000006866 deterioration Effects 0.000 description 2
238000010586 diagram Methods 0.000 description 2
230000000694 effects Effects 0.000 description 2
238000002347 injection Methods 0.000 description 2
239000007924 injection Substances 0.000 description 2
238000007689 inspection Methods 0.000 description 2
230000005855 radiation Effects 0.000 description 2
WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 1
238000003556 assay Methods 0.000 description 1
229910052790 beryllium Inorganic materials 0.000 description 1
ATBAMAFKBVZNFJ-UHFFFAOYSA-N beryllium atom Chemical compound [Be] ATBAMAFKBVZNFJ-UHFFFAOYSA-N 0.000 description 1
239000013078 crystal Substances 0.000 description 1
230000001419 dependent effect Effects 0.000 description 1
230000003831 deregulation Effects 0.000 description 1
230000005611 electricity Effects 0.000 description 1
238000005516 engineering process Methods 0.000 description 1
239000011521 glass Substances 0.000 description 1
GPRLSGONYQIRFK-UHFFFAOYSA-N hydron Chemical compound [H+] GPRLSGONYQIRFK-UHFFFAOYSA-N 0.000 description 1
230000010354 integration Effects 0.000 description 1
229910052742 iron Inorganic materials 0.000 description 1
239000011344 liquid material Substances 0.000 description 1
229910001338 liquidmetal Inorganic materials 0.000 description 1
229910052744 lithium Inorganic materials 0.000 description 1
238000012986 modification Methods 0.000 description 1
230000004048 modification Effects 0.000 description 1
230000002093 peripheral effect Effects 0.000 description 1
239000004033 plastic Substances 0.000 description 1
229920003023 plastic Polymers 0.000 description 1
238000012545 processing Methods 0.000 description 1
238000007493 shaping process Methods 0.000 description 1
238000002603 single-photon emission computed tomography Methods 0.000 description 1
239000007787 solid Substances 0.000 description 1
230000001360 synchronised effect Effects 0.000 description 1
229910052715 tantalum Inorganic materials 0.000 description 1
GUVRBAGPIYLISA-UHFFFAOYSA-N tantalum atom Chemical compound [Ta] GUVRBAGPIYLISA-UHFFFAOYSA-N 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 description 1
229910052721 tungsten Inorganic materials 0.000 description 1
239000010937 tungsten Substances 0.000 description 1
238000011144 upstream manufacturing Methods 0.000 description 1

Classifications

- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21K—TECHNIQUES FOR HANDLING PARTICLES OR IONISING RADIATION NOT OTHERWISE PROVIDED FOR; IRRADIATION DEVICES; GAMMA RAY OR X-RAY MICROSCOPES
- G21K5/00—Irradiation devices
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1048—Monitoring, verifying, controlling systems and methods
- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
- H05H3/00—Production or acceleration of neutral particle beams, e.g. molecular or atomic beams
- H05H3/06—Generating neutron beams
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N2005/1085—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy characterised by the type of particles applied to the patient
- A61N2005/109—Neutrons

Landscapes

Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Physics & Mathematics (AREA)
General Health & Medical Sciences (AREA)
Radiology & Medical Imaging (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pathology (AREA)
High Energy & Nuclear Physics (AREA)
Spectroscopy & Molecular Physics (AREA)
General Engineering & Computer Science (AREA)
Plasma & Fusion (AREA)
Radiation-Therapy Devices (AREA)

CN201610118023.1A 2015-03-05 2016-03-02 中子捕捉疗法装置 Active CN105938731B (zh)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP2015-043840		2015-03-05
JP2015043840A JP6565113B2 (ja)	2015-03-05	2015-03-05	中性子捕捉療法装置

Publications (2)

Publication Number	Publication Date
CN105938731A CN105938731A (zh)	2016-09-14
CN105938731B true CN105938731B (zh)	2018-03-30

Family

ID=56843849

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CN201610118023.1A Active CN105938731B (zh)	2015-03-05	2016-03-02	中子捕捉疗法装置

Country Status (3)

Country	Link
JP (1)	JP6565113B2 (ja)
CN (1)	CN105938731B (ja)
TW (1)	TWI589325B (ja)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
RU2697763C1 (ru) *	2016-01-15	2019-08-19	Нойборон Медтех Лтд.	Система детектирования излучения для системы нейтрон-захватной терапии и способ детектирования излучения
KR101862645B1 (ko) *	2016-10-31	2018-06-01	가천대학교 산학협력단	Mri를 이용한 bnct를 위한 붕소의 농도분포 측정방법, 및 bnct의 치료 계획방법
JP6831921B2 (ja) *	2016-10-31	2021-02-17	南京中硼▲聯▼康医▲療▼科技有限公司ＮｅｕｂｏｒｏｎＭｅｄｔｅｃｈＬｔｄ．	中性子捕獲治療システム
TWI614042B (zh) *	2016-12-02	2018-02-11	財團法人工業技術研究院	中子束源產生器及其濾屏
CN110418666A (zh) *	2017-03-13	2019-11-05	住友重机械工业株式会社	中子捕捉疗法***及控制装置
JP6829837B2 (ja) *	2017-03-29	2021-02-17	住友重機械工業株式会社	中性子捕捉療法システム及び中性子捕捉療法用ガンマ線検出器
CN109925606B (zh) *	2017-12-15	2024-03-22	南京中硼联康医疗科技有限公司	中子捕获治疗***
CN109011221A (zh) *	2018-09-04	2018-12-18	东莞东阳光高能医疗设备有限公司	一种剂量引导的中子俘获治疗***及其操作方法
DE102018007843B3 (de) *	2018-10-01	2020-01-16	Forschungszentrum Jülich GmbH	Verfahren zum Auffinden eines Targetmaterials und Targetmaterial für eine Neutronenquelle
JPWO2020241415A1 (ja) *	2019-05-30	2020-12-03
JP7430044B2 (ja) *	2019-09-17	2024-02-09	住友重機械工業株式会社	放射線治療装置
CN113877076B (zh) *	2020-07-03	2023-11-24	中硼(厦门)医疗器械有限公司	中子捕获治疗设备
JP7485587B2 (ja) *	2020-11-13	2024-05-16	株式会社日立製作所	粒子線監視システム、粒子線監視方法および粒子線治療システム
DE102022132084A1 (de)	2022-12-02	2024-06-13	Horia Hulubei National Institute for R & D in Physics and Nuclear Engineering (IFIN-HH)	Vorrichtung zum Porieren und zum Beladen von Zellen sowie Verfahren hierfür
DE102022132083A1 (de)	2022-12-02	2024-06-13	Horia Hulubei National Institute for R & D in Physics and Nuclear Engineering (IFIN-HH)	Vorrichtung zum Porieren und zum Beladen von Zellen sowie Verfahren hierfür
DE102022132082A1 (de)	2022-12-02	2024-06-13	Horia Hulubei National Institute for R & D in Physics and Nuclear Engineering (IFIN-HH)	Verfahren zur Herstellung von genetisch transfizierten und mit Nanopartikeln und/oder einem zytotoxischen Stoff beladenen immunokompetenten Zellen sowie immunokompetente Zellen und medizinische Zusammensetzung.

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP3340949B2 (ja) *	1997-11-21	2002-11-05	関西電力株式会社	コリメーター及びγ線検出装置
JP2004233168A (ja) *	2003-01-29	2004-08-19	Japan Science & Technology Agency	中性子捕捉療法に用いる中性子遮蔽板、およびヒト以外の哺乳動物に対して行なう中性子捕捉療法、ならびに治療用中性子照射装置
CN201126720Y (zh) *	2007-12-11	2008-10-01	中国原子能科学研究院	钠冷快堆用γ光谱测量准直器
FR2930995B1 (fr) *	2008-05-07	2010-07-30	Centre Nat Rech Scient	Procede et dispositif de mesure en temps reel d'une dose locale lors du bombardement d'une cible par des hadrons au moyen des gamma prompts
CN102985981B (zh) *	2010-07-28	2016-08-24	住友重机械工业株式会社	中子线照射装置及中子线照射装置的控制方法
JP5490651B2 (ja) *	2010-09-01	2014-05-14	住友重機械工業株式会社	中性子線照射システム
NL2007596C2 (en) *	2011-10-14	2013-04-16	Univ Delft Tech	A hadron radiation installation and verification method.
JP5630666B2 (ja) *	2012-03-30	2014-11-26	住友重機械工業株式会社	中性子捕捉療法用コリメータ及び中性子捕捉療法装置
JP5996470B2 (ja) *	2013-03-29	2016-09-21	住友重機械工業株式会社	中性子捕捉療法装置
JP6042269B2 (ja) *	2013-05-22	2016-12-14	住友重機械工業株式会社	中性子捕捉療法装置、及び中性子線の測定方法

2015
- 2015-03-05 JP JP2015043840A patent/JP6565113B2/ja active Active
2016
- 2016-03-02 TW TW105106334A patent/TWI589325B/zh active
- 2016-03-02 CN CN201610118023.1A patent/CN105938731B/zh active Active

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Optimization Technique for a Prompt Gamma-ray SPECT Collimator System;MASAYORI ISHIKAWA,et al.;《J.RADIAT.RES》;20011231;第387-400页 *

Also Published As

Publication number	Publication date
JP6565113B2 (ja)	2019-08-28
TW201634075A (zh)	2016-10-01
CN105938731A (zh)	2016-09-14
JP2016159107A (ja)	2016-09-05
TWI589325B (zh)	2017-07-01

Legal Events

Date	Code	Title
2016-09-14	C06	Publication
2016-09-14	PB01	Publication
2016-10-19	C10	Entry into substantive examination
2016-10-19	SE01	Entry into force of request for substantive examination
2018-03-30	GR01	Patent grant
2018-03-30	GR01	Patent grant

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JP7248470B2 (ja)	2023-03-29	中性子線検出装置
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