CN105877875A - Personalized thyroid cartilage prosthesis and production method thereof - Google Patents
Personalized thyroid cartilage prosthesis and production method thereof Download PDFInfo
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- CN105877875A CN105877875A CN201610365421.3A CN201610365421A CN105877875A CN 105877875 A CN105877875 A CN 105877875A CN 201610365421 A CN201610365421 A CN 201610365421A CN 105877875 A CN105877875 A CN 105877875A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/0063—Implantable repair or support meshes, e.g. hernia meshes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/04—Metals or alloys
- A61L27/06—Titanium or titanium alloys
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y10/00—Processes of additive manufacturing
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y50/00—Data acquisition or data processing for additive manufacturing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/0063—Implantable repair or support meshes, e.g. hernia meshes
- A61F2002/0068—Implantable repair or support meshes, e.g. hernia meshes having a special mesh pattern
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Manufacturing & Machinery (AREA)
- Materials Engineering (AREA)
- Inorganic Chemistry (AREA)
- Dermatology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Prostheses (AREA)
Abstract
The invention discloses a personalized thyroid cartilage prosthesis and a production method thereof. The method includes: scanning an affected part to obtain lamella data, importing the lamella data into Mimics software, performing threshold segmentation on the lamella data, and performing region growing to further subdivide the disconnected segmentation regions on a primary threshold segmentation masking so as to generate a new masking; importing a rebuilt point cloud model into reverse engineering software, packaging point cloud to generate an STL-format triangular patch model, and extracting the contour curve surface of an excision part; importing the extracted curve surface into universal three-dimensional software to complete modeling, using Grasshopper to extract incisive bone corresponding surface profile, and generating a meshed porous structure on an incisive bone surface; performing motion simulation stress analysis on the biological fixation type thyroid cartilage prosthesis, and outputting adjusting parameters for real-time adjusting so as to optimize the design according the finite element motion stress analysis result. The thyroid cartilage prosthesis produced by the method is of a curve surface structure and corresponds to the shape of a to-be-replaced part, and accordingly the adverse effect caused by surgery can be eliminated effectively.
Description
Technical field
The present invention relates to print based on 3D and manufacture medical science implantation prosthese, particularly relate to a kind of personalized first shape soft
Bone prosthese and preparation method thereof.
Background technology
Laryngeal carcinoma or injury of larynx patient inevitably cut away all or part of first shape in operation process
Cartilage, owing to thyroid cartilage belongs to non-renewable tissue, thyroid defect can have a strong impact on patient
Function of deglutition, vocal function and work of breathing function etc., make patient's postoperative life quality reduce, and severe patient is very
To causing death.The most domestic carry out Surgery for Laryngeal Carcinoma time typically can reduce thyroid excision model as far as possible
Enclose, thus reduce the side effect that thyroid cartilage defect is brought, but this processing mode reliability is the highest.
The domestic hospital that can carry out thyroid cartilage Using prosthesis operation still belongs to minority, and the case of successful surgery
The rarest report of example.In operation process, the wire netting of the prosthese of implantation typically doctor's plane is former
Material carries out shaped by hand to it and obtains.The effect of prosthese shaped by hand fully relies on the warp of doctor individual
Test, it is impossible to the thyroid cartilage cut with patient mates completely, effectively overcome cartilage although the most postoperative
The side effect that disappearance is brought, but original appearance cannot be replied in appearance.
Summary of the invention
It is an object of the invention to overcome the shortcoming and defect of above-mentioned prior art, it is provided that a kind of support effect
Well, personalized thyroid cartilage prosthese of simple in construction and preparation method thereof.The first shape prepared by the method
Cartilage prosthese, its shape structure in curved surface, and corresponding with alternative site shape, thus effectively eliminate
The harmful effect that operation is brought.
The present invention is achieved through the following technical solutions:
A kind of personalized thyroid cartilage prosthese preparation method, it is characterised in that comprise the steps:
Step A00；Scan patient part by CT or MRT, obtain sheet layer data；
Step B00；The sheet layer data obtained is imported in Mimics software, it is carried out Threshold segmentation,
The cut zone that region increases being not connected with each other in preliminary threshold segmentation masking-out segments subgroup further,
Generate new masking-out；Finally smooth it, denoising etc. operates, and obtains the point cloud model after reconstruction；
Step C00；Point cloud model after rebuilding imports Geomagic Studio, is packaged a cloud
Generate the tringle coal of STL form, extract the contour surface at cut position；
Step D00；The modeling of loose structure is realized by any one method in the following two kinds method:
Method (1): the curved surface of extraction is imported general three-dimensional software and completes modeling, pass through Grasshopper
Extract deep corresponding surface profile, generate reticulated porous structures in osteotomy surface；Or
Method (2): led by the curved surface of extraction and carry out force analysis of finite element, extracts force analysis posterior nodal point letter
Breath, utilizes Grasshopper to complete finite element loose structure in Rhinoceros software；
Step E00: personalized thyroid cartilage prosthese is carried out motion simulation force analysis, transports according to finite element
Dynamic force analysis result, input regulation parameter adjusts in real time, optimizes design；
Step F00: obtain three-dimensional entity model, carries out slicing delamination, path planning, imports 3D metal
Printing device, carries out 3D solid molding；
In above-mentioned steps D00, the threedimensional model after method (1) specifically will be rebuild is introduced directly into
In Grasshopper, carry out Control curve parameter by coding, input variable is set and controls to excise model
Enclose；Cut curved surface sets up network structure, by the regulation cancellated thickness of parameter i.e. adjustable
Degree, grid hole porosity, average pore size；It is carried out motion simulation force analysis, moves according to finite element
Force analysis result input regulation parameter adjusts in real time, optimizes design.
In above-mentioned steps D00, the model after Rhinoceros cutting is specifically imported by method (2)
Autodesk Simulation Mechanical, arranges network size to it, carries out tetrahedron or hexahedro
Body or mixed mesh, grid optimization, after adding material properties, after imposed load and constraint, carry out
Finite Element Simulation Analysis；By thyroid cartilage prosthese Finite element analysis results, from Autodesk Simulation
Mechanical software platform is derived with Excel form document form, extracts node location information；Lead
Enter Rhinoceros software, utilize Grasshopper to write battery figure program, defeated to realize by regulation
Entering parameter to change model, detailed process is as follows:
1. open Rhinoceros software and read Excel file by Grasshopper, limited to read
Meta-model nodal information；
2. battery figure program is write by a generation line, baking by the Grasshopper plug-in unit of Rhinoceros
After rhinoceros software is arrived in training, deletion of node information；
3. again read in the model of deletion of node with Grasshopper, write battery program, carry out structure excellent
Change, line generate curved surface, sew up, after adding a cover, generate body；The model that Grasshopper is generated
After carrying out smooth operation such as grade, bake and bank up with earth in Rhinoceros software, thus realize having of thyroid cartilage prosthese
Limit unit parametric modeling.
In the print procedure of 3D metallic print equipment described in step F00,
(1) size of n Yu N is judged；
(2) if n < N, step F00 is performed；
(3) if n >=N, step I00 is performed；
(4) print complete, obtain satisfactory biological fixation type thyroid cartilage prosthese；
Wherein, n >=N.
Through 3D metallic print equipment print the personalized thyroid cartilage prosthese prepared need annealed, sandblasting,
Electrobrightening, mirror finish process.The material that 3D metallic print equipment is used is titanium alloy powder.
A kind of personalized thyroid cartilage prosthese, this thyroid cartilage prosthese is curved surface network structure, this net surfaces
Shape structure is divided into: network structure left plate region 100, fixed area 200, network structure right panel region 300
With Adam's apple region 400；The corresponding cut thyroid cartilage region of curved surface network structure, fixed area 200 sets
There is screw hole；Described fixed area 200 is positioned at the cancellated two ends of curved surface；Described Adam's apple region 400
Outer margin contour be U-shaped rounding off.(it is cut that outer margin contour shape extracts from patient's thyroid cartilage completely
Position, the most not necessarily rounding off)
The cancellated shape of described curved surface and size and patient need excision thyroid shape and
Scope is corresponding.
Described curved surface network structure is monolayer network structure or multilamellar network structure；
Curved surface network structure is titanium alloy material；
The cancellated mesh-density of described curved surface, can be adjusted according to different implant sites.(grid is close
Degree does not has this fixing Changing Pattern, needs to determine according to the actual demand of finite element analysis and patient)
The cancellated grid of described curved surface is any in continuous print triangle, rectangle or roundness mess
One or combination；When using triangular mesh, the base of each triangular mesh and tip are distributed many
The lines that bar is parallel to each other.
Described curved surface network structure integral thickness is consistent, or by thinning between central region to exterior lateral area
Or it is the most thickening.This structure more has personalization.
The cancellated size of mesh opening of described curved surface, middle part to two ends be gradually reduced or between increase.
The present invention, relative to prior art, has such advantages as and effect:
Owing to the Data Source of prosthese modelling is in patient self, so the shape of prosthese is corresponding with patient
Position is mated completely, it is achieved that personalization truly；By using parametric modeling method,
The change of model need not redesign, it is only necessary to regulation input parameter just can complete, and can be greatly improved
Design efficiency；Owing to using parametric modeling method, can be directly by regulation input parameter regulation grid-shaped
Shape, mesh-density, web thickness are to adapt to the actual demand of different patient；It is imitative owing to it is carried out motion
True force analysis, can realize the optimum allocation of biological fixation type thyroid cartilage prosthese power, thus reduce postoperative
The risk that prosthese damages；Owing to using titanium alloy powder to carry out metallic print, the thyroid cartilage after molding is false
Body can realize good biocompatibility after implanting human body；(raw owing to using 3D Method of printing to make
Thing fixed pattern) structure of implanting prosthese no longer limited by process conditions, irregular complicated bent to having
Face and porous network structure can realize directly manufacturing；Owing to using laser 3D to print so that implant
The mechanical property of prosthese is the most superior；By to implanting the parametric modeling of prosthese and SLM straight forming,
Design efficiency can be greatly improved, reach directly to manufacture the purpose of personalized implant, implant vacation to improving
In the service life of body, the quality of life of patient is significant.
Thyroid cartilage prosthese of the present invention is curved surface network structure, and effect is to support throat muscles tissue, not only
Can adapt to different individual requirements, and muscular tissue inside and outside network structure can be made to stick and pass grid
Normal growth.
Accompanying drawing explanation
Fig. 1 is personalization thyroid cartilage borrowed structure schematic diagram of the present invention.
Fig. 2 is personalization thyroid cartilage prosthese front view of the present invention.
Fig. 3 is personalization thyroid cartilage prosthese top view of the present invention.
Fig. 4 is this personalization thyroid cartilage prosthese preparation technology flow chart.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is more specifically described in detail.
Embodiment
Also known as " metal 3D prints selective laser fusing (Selective Laser Melting, SLM) technology
Technology " it is to increase the cutting edge technology that material manufactures, utilize the focusing laser beam of diameter 30～50 microns, metal
Or alloy powder constituency successively melts, it is piled into a metallurgical binding, the entity of dense structure, thus obtains
Almost arbitrary shape, there is the metal function part of complete metallurgical binding.
As shown in Figures 1 to 4.The invention discloses a kind of personalized thyroid cartilage prosthese preparation method, logical
Cross following steps to realize:
Step A00；Scan patient part by CT or MRT, obtain sheet layer data；
Step B00；The sheet layer data obtained is imported in Mimics software, it is carried out Threshold segmentation,
The cut zone that region increases being not connected with each other in preliminary threshold segmentation masking-out segments subgroup further,
Generate new masking-out；Finally smooth it, denoising etc. operates, and obtains the point cloud model after reconstruction；
Step C00；Point cloud model after rebuilding imports Geomagic Studio, is packaged a cloud
Generate the tringle coal of STL form, extract the contour surface at cut position；
Step D00；The modeling of loose structure is realized by any one method in the following two kinds method:
Method (1): the curved surface of extraction is imported general three-dimensional software and completes modeling, pass through Grasshopper
Extract deep corresponding surface profile, generate reticulated porous structures in osteotomy surface；Or
Method (2): led by the curved surface of extraction and carry out force analysis of finite element, extracts force analysis posterior nodal point letter
Breath, utilizes Grasshopper to complete finite element loose structure in Rhinoceros software；
Step E00: personalized thyroid cartilage prosthese is carried out motion simulation force analysis, transports according to finite element
Dynamic force analysis result, input regulation parameter adjusts in real time, optimizes design；
Step F00: obtain three-dimensional entity model, carries out slicing delamination, path planning, imports 3D metal
Printing device, carries out 3D solid molding；
In above-mentioned steps D00, the threedimensional model after method (1) specifically will be rebuild is introduced directly into
In Grasshopper, carry out Control curve parameter by coding, input variable is set and controls to excise model
Enclose；Cut curved surface sets up network structure, by the regulation cancellated thickness of parameter i.e. adjustable
Degree, grid hole porosity, average pore size；It is carried out motion simulation force analysis, moves according to finite element
Force analysis result input regulation parameter adjusts in real time, optimizes design.
Set up network structure on cut curved surface, refer to by the part or all of thyroid cartilage of excision
Network structure is set up on the surface model of front surface.Need exist for explanation, if patient's thyroid cartilage quilt
Excise position corrupted the most or disappearance and complete data cannot be extracted, then can extract offside corresponding
The data in intact region carry out mirror image modeling, or at the defective thyroid CT extracted or
After MRT image carries out three-dimensional modeling, the threedimensional model surface at defective position is carried out manual process, thus
It is met the curved surface of operation demand.
Space curved surface network structure, is to program, by setting in Grasshopper based on Grasshopper
Put mesh-density, mesh shape, web thickness regulation parameter input point, can be directly by regulation input ginseng
Number regulation mesh-density, mesh shape, web thickness, to adapt to the actual demand of patient.
In above-mentioned steps D00, method (2) specifically parameterized finite element modeling, the advantage of this method
It it is the optimum allocation that node can be ranked up realizing according to stressing conditions power.Detailed description of the invention is:
Model after Rhinoceros cutting is imported Autodesk Simulation Mechanical, it is set
Put network size, carry out tetrahedron or hexahedron or mixed mesh, grid optimization, add material and belong to
After property, after imposed load and constraint, carry out Finite Element Simulation Analysis (general finite element analysis software)；
By thyroid cartilage prosthese Finite element analysis results, from Autodesk Simulation Mechanical software
Platform is derived with Excel form document form, extracts node location information；Import Rhinoceros soft
Part, utilizes Grasshopper to write battery figure program, to realize by adjusting input parameters to change mould
Type, detailed process is as follows:
1. open Rhinoceros software and read Excel file by Grasshopper, limited to read
Meta-model nodal information；
2. battery figure program is write by a generation line, baking by the Grasshopper plug-in unit of Rhinoceros
After rhinoceros software is arrived in training, deletion of node information；
3. again read in the model of deletion of node with Grasshopper, write battery program, carry out structure excellent
Change, line generate curved surface, sew up, after adding a cover, generate body；The model that Grasshopper is generated
After carrying out smooth operation such as grade, bake and bank up with earth in Rhinoceros software, thus realize having of thyroid cartilage prosthese
Limit unit parametric modeling.
In the print procedure of 3D metallic print equipment described in step F00,
(1) size of n Yu N is judged；
(2) if n < N, step F00 is performed；
(3) if n >=N, step I00 is performed；
(4) print complete, obtain satisfactory biological fixation type thyroid cartilage prosthese；
Wherein, n >=N.
Through 3D metallic print equipment print the personalized thyroid cartilage prosthese prepared need annealed, sandblasting,
Electrobrightening, mirror finish process.The material that 3D metallic print equipment is used is titanium alloy powder.
Personalization thyroid cartilage prosthese of the present invention, is according to thyroid cartilage by metal 3D laser printing apparatus
Prosthese cross section profile data, control laser beam and optionally melt each layer metal dust paved, progressively heap
Fold and form.Within formed precision can be controlled in 100 μm.
This thyroid cartilage prosthese is curved surface network structure, and effect is to support throat muscles tissue, and can make net
Inside and outside shape structure, grid normal growth is sticked and passed to muscular tissue, therefore can realize the above net acted on
Trellis shape.
This curved surface network structure is divided into: network structure left plate region 100, fixed area 200, network structure
Right panel region 300 and Adam's apple region 400；The corresponding cut thyroid cartilage region of curved surface network structure, Gu
Determining region 200 and be provided with screw hole, position and the number of screw hole are not fixed, depending on patient practical situation and
Fixed, network structure and fixed structure consistency of thickness, the concrete numerical value of thickness should be regarding the practical situation of patient
Fixed.Described fixed area 200 is positioned at the cancellated two ends of curved surface；The outer rim in described Adam's apple region 400
Profile is U-shaped rounding off.
The cancellated shape of described curved surface and size and patient need excision thyroid shape and
Scope is corresponding.
Described curved surface network structure is monolayer network structure or multilamellar network structure；Its effect is to support
Throat muscles tissue, and muscular tissue inside and outside network structure can be made to stick and pass grid normal growth.
Curved surface network structure is titanium alloy material；In order to improve the quality of molding, titanium alloy (powder) is former
Material needs through filtering and drying and processing before adding powder cylinder: by titanium alloy powder raw material through shaking
Dynamic sieve filters, to filter the impurity in powder raw material；Again powder raw material is carried out drying and processing,
To reduce the oxygen content of powder raw material.Titanium alloy powder raw material enters from 3D metallic print equipment and prints
Region can be by realizing for powder form or dusting powders.
The cancellated mesh-density of described curved surface, can be adjusted according to different implant sites, to adapt to
Different individual requirements.
The cancellated grid of described curved surface is any in continuous print triangle, rectangle or roundness mess
One or combination；When using triangular mesh, the base of each triangular mesh and tip are distributed many
The lines that bar is parallel to each other；This structure is conducive to the cancellated extensibility of curved surface and support strength.
Described curved surface network structure integral thickness is consistent, or by thinning between central region to exterior lateral area
Or it is the most thickening.This structure more has personalization, to adapt to different individual requirements；
The cancellated size of mesh opening of described curved surface, middle part to two ends be gradually reduced or between increase,
To adapt to different individual requirements.
Personalization thyroid cartilage prosthese of the present invention is mounted in the outside of cut thyroid cartilage corresponding region
Substitute cut thyroid cartilage, its shape be according to patient need excision thyroid scope and
Determine.Several screw holes on its cancellated border, thyroid cartilage in laminating correct in operation process
Screw special fixed fae body is used after prosthese.
As it has been described above, just can preferably realize the present invention.
Embodiments of the present invention are also not restricted to the described embodiments, and other are any without departing from the present invention's
The change made under spirit and principle, modify, substitute, combine, simplify, all should be putting of equivalence
Change mode, within being included in protection scope of the present invention.
Claims (10)
1. a personalized thyroid cartilage prosthese preparation method, it is characterised in that comprise the steps:
Step A00；Scan patient part by CT or MRT, obtain sheet layer data；
Step B00；The sheet layer data obtained is imported in Mimics software, it is carried out Threshold segmentation,
The cut zone that region increases being not connected with each other in preliminary threshold segmentation masking-out segments subgroup further,
Generate new masking-out；Finally smooth it, denoising etc. operates, and obtains the point cloud model after reconstruction；
Step C00；Point cloud model after rebuilding imports Geomagic Studio, is packaged a cloud
Generate the tringle coal of STL form, extract the contour surface at cut position；
Step D00；The modeling of loose structure is realized by any one method in the following two kinds method:
Method (1): the curved surface of extraction is imported general three-dimensional software and completes modeling, pass through Grasshopper
Extract deep corresponding surface profile, generate reticulated porous structures in osteotomy surface；Or
Method (2): led by the curved surface of extraction and carry out force analysis of finite element, extracts force analysis posterior nodal point letter
Breath, utilizes Grasshopper to complete finite element loose structure in Rhinoceros software；
Step E00: personalized thyroid cartilage prosthese is carried out motion simulation force analysis, transports according to finite element
Dynamic force analysis result, input regulation parameter adjusts in real time, optimizes design；
Step F00: obtain three-dimensional entity model, carries out slicing delamination, path planning, imports 3D metal
Printing device, carries out 3D solid molding.
The most personalized thyroid cartilage prosthese preparation method, it is characterised in that step
In rapid D00, the threedimensional model after method (1) specifically will be rebuild is introduced directly in Grasshopper,
Carry out Control curve parameter by coding, input variable is set to control excision extension；Cut
Set up network structure on curved surface, by regulation the cancellated thickness of parameter i.e. adjustable, grid hole porosity,
Average pore size；It is carried out motion simulation force analysis, inputs according to finite element motion force analysis result
Regulation parameter adjusts in real time, optimizes design.
The most personalized thyroid cartilage prosthese preparation method, it is characterised in that step
In rapid D00, the model after Rhinoceros cutting is specifically imported Autodesk by method (2)
Simulation Mechanical, arranges network size to it, carries out tetrahedron or hexahedron or hybrid network
Lattice divide, grid optimization, after adding material properties, after imposed load and constraint, carry out finite element simulation
Analyze；By thyroid cartilage prosthese Finite element analysis results, from Autodesk Simulation Mechanical
Software platform is derived with Excel form document form, extracts node location information；Import Rhinoceros
Software, utilizes Grasshopper to write battery figure program, to realize by adjusting input parameters to change
Model, detailed process is as follows:
1. open Rhinoceros software and read Excel file by Grasshopper, limited to read
Meta-model nodal information；
2. battery figure program is write by a generation line, baking by the Grasshopper plug-in unit of Rhinoceros
After rhinoceros software is arrived in training, deletion of node information；
3. again read in the model of deletion of node with Grasshopper, write battery program, carry out structure excellent
Change, line generate curved surface, sew up, after adding a cover, generate body；The model that Grasshopper is generated
After carrying out smooth operation such as grade, bake and bank up with earth in Rhinoceros software, thus realize having of thyroid cartilage prosthese
Limit unit parametric modeling.
The most personalized thyroid cartilage prosthese preparation method, it is characterised in that
In the print procedure of 3D metallic print equipment described in step F00,
(1) size of n Yu N is judged；
(2) if n < N, step F00 is performed；
(3) if n >=N, step I00 is performed；
(4) print complete, obtain satisfactory biological fixation type thyroid cartilage prosthese；
Wherein, n >=N.
The most personalized thyroid cartilage prosthese preparation method, it is characterised in that warp
3D metallic print equipment prints the personalized thyroid cartilage prosthese prepared needs annealed, sandblasting, electrolysis
Polishing, mirror finish process.
The most personalized thyroid cartilage prosthese preparation method, it is characterised in that should
The material that 3D metallic print equipment is used is titanium alloy powder.
7. a personalized thyroid cartilage prosthese, it is characterised in that use any one of claim 1 to 6
Described personalized thyroid cartilage prosthese preparation method prepares, and this thyroid cartilage prosthese is curved surface network structure；
This curved surface network structure is divided into: network structure left plate region (100), fixed area (200), net
Shape structure right panel region (300) and Adam's apple region (400)；The corresponding cut first shape of curved surface network structure
Cartilaginous areas, fixed area (200) is provided with screw hole；
Described fixed area (200) is positioned at the cancellated two ends of curved surface；Described Adam's apple region (400)
Outer margin contour be U-shaped rounding off.
The most personalized thyroid cartilage prosthese, it is characterised in that described net surfaces
The shape of shape structure and size need the thyroid shape of excision and scope corresponding with patient.
The most personalized thyroid cartilage prosthese, it is characterised in that described net surfaces
Shape structure is monolayer network structure or multilamellar network structure；
Curved surface network structure is titanium alloy material.
The most personalized thyroid cartilage prosthese, it is characterised in that described curved surface
Cancellated grid is any one or combination in continuous print triangle, rectangle or roundness mess；
When using triangular mesh, the base of each triangular mesh and tip are distributed a plurality of line being parallel to each other
Bar；
Described curved surface network structure integral thickness is consistent, or by thinning between central region to exterior lateral area
Or it is the most thickening；
The cancellated size of mesh opening of described curved surface, middle part to two ends be gradually reduced or between increase.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610365421.3A CN105877875A (en) | 2016-05-27 | 2016-05-27 | Personalized thyroid cartilage prosthesis and production method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610365421.3A CN105877875A (en) | 2016-05-27 | 2016-05-27 | Personalized thyroid cartilage prosthesis and production method thereof |
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| CN106344221A (en) * | 2016-10-26 | 2017-01-25 | 四川大学 | Bonelike porous biomechanical bionic designed spinal fusion device and preparation method and use thereof |
| CN106420117A (en) * | 2016-11-09 | 2017-02-22 | 河北医科大学第三医院 | Bone tumor prosthesis for firmly connecting tendon and making method thereof |
| CN107137167A (en) * | 2017-05-05 | 2017-09-08 | 南方医科大学 | Modeling method, manufacture method and the Auricular framework of the exposed Auricular framework of prevention |
| CN107802378A (en) * | 2017-11-22 | 2018-03-16 | 华南理工大学 | Astragalus local route repair body and its design and production method with loose structure |
| CN107968080A (en) * | 2018-01-04 | 2018-04-27 | 钦州学院 | Microelectronics heat exchanger and its manufacture method based on earthworm microcosmic surface |
| CN108010893A (en) * | 2018-01-04 | 2018-05-08 | 钦州学院 | Minitype radiator and its manufacture method based on lotus leaf microcosmic surface |
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| CN109049719B (en) * | 2018-09-30 | 2020-07-17 | 西安点云生物科技有限公司 | Silk-free 3D printing method |
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| CN110811929A (en) * | 2019-11-07 | 2020-02-21 | 西安交通大学 | Personalized lower limb long bone segment substitute and preparation method thereof |
| CN111249038A (en) * | 2020-01-14 | 2020-06-09 | 国家康复辅具研究中心 | Method for producing a bone implant with an integrated porous structure and bone implant |
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| CN112140552B (en) * | 2020-07-23 | 2021-12-28 | 西安交通大学 | In-situ 3D printing curved surface layering and path planning method |
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