CN105581860A - 3D print type artificial bone trabecula structure cervical fusion device and preparing method and application thereof - Google Patents

3D print type artificial bone trabecula structure cervical fusion device and preparing method and application thereof Download PDF

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Publication number
CN105581860A
CN105581860A CN201610015538.9A CN201610015538A CN105581860A CN 105581860 A CN105581860 A CN 105581860A CN 201610015538 A CN201610015538 A CN 201610015538A CN 105581860 A CN105581860 A CN 105581860A
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fusion device
bone
cervical
prints
powder
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李鹏
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Beijing Zhongnuo Hengkang Biotechnology Co., Ltd.
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李鹏
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Priority to CN201610015538.9A priority Critical patent/CN105581860A/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/3094—Designing or manufacturing processes
    • A61F2/30942—Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F3/00—Manufacture of workpieces or articles from metallic powder characterised by the manner of compacting or sintering; Apparatus specially adapted therefor ; Presses and furnaces
    • B22F3/10—Sintering only
    • B22F3/11—Making porous workpieces or articles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B33—ADDITIVE MANUFACTURING TECHNOLOGY
    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y10/00—Processes of additive manufacturing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B33—ADDITIVE MANUFACTURING TECHNOLOGY
    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y80/00—Products made by additive manufacturing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30621—Features concerning the anatomical functioning or articulation of the prosthetic joint
    • A61F2002/30622—Implant for fusing a joint or bone material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
    • A61F2/30771—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
    • A61F2002/30772—Apertures or holes, e.g. of circular cross section
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/3094—Designing or manufacturing processes
    • A61F2002/30985—Designing or manufacturing processes using three dimensional printing [3DP]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00011—Metals or alloys
    • A61F2310/00023—Titanium or titanium-based alloys, e.g. Ti-Ni alloys

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Manufacturing & Machinery (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Transplantation (AREA)
  • Animal Behavior & Ethology (AREA)
  • Materials Engineering (AREA)
  • Cardiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
  • Physics & Mathematics (AREA)
  • Geometry (AREA)
  • Mechanical Engineering (AREA)
  • Prostheses (AREA)
  • Materials For Medical Uses (AREA)

Abstract

The invention discloses an anterior spinal and cervical 3D print type artificial bone trabecula structure cervical fusion device. The device is characterized by comprising an entity support, the entity support comprises a horizontal plane entity support body (1) and an axial position entity support body (3), and a porous structure (2) is arranged in the middle of the entity support. The porous structure simulating the cancellous bone of the human body is manufactured in the 3D mode, a bone ingrowth support is provided, and the osteogenesis process is promoted; support pillars are additionally arranged on the periphery and on the sides to improve mechanical property, the elasticity modulus of the entity support is made to be close to that of a contact surface, and then shielding is avoided. Implantation of human bone is not needed, bone taking amount in surgery can be further reduced, the number of operative wounds is reduced, and surgery can be finished in a minimally invasive mode.

Description

3D prints Bionics Bone trabecularism Cervical Fusion device, preparation method and application
Technical field
The loose structure that the present invention relates to a kind of operating 3D apery body cancellous bone, relates in particular to a kind of 3DPrint Bionics Bone trabecularism Cervical Fusion device, preparation method and application thereof.
Background technology
Cervical operation mainly contains anterior approach and posterior approach at present, in anterior approach, need to excise pathologyInterverbebral disc, with artificial cervical vertebral fusion cage substitute. The present fusion device using clinically needs a large amount of implantation certainlyBody bone or allograph bone are to have reached the object of intervertebral fusion. In the situation of autologous bone deficiency, need to get ilium,The extra injury bringing to patient like this, if too much implant allograph bone packing material, exists inflammatory occursReaction or allosome are got rid of reaction, and then cause the failure of operation.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of 3D and prints Bionics Bone trabecularism Cervical Fusion dressPut, preparation method and application, overcome the shortcoming of above-mentioned prior art.
The present invention is based on following principle:
By the development of present 3D printing technique, can simulate on computers the structure of cancellous bone, then logicalCross the entity that modeling manufacture has cancellous bone structure and support, after thering is the entity of cancellous bone structure and supporting and insertCan play the effect of support, be conducive to the generation of osteogenetic process, and then promote quick bone to merge.
Technical problem to be solved by this invention is achieved through the following technical solutions:
A kind of 3D prints Bionics Bone trabecularism Cervical Fusion device, comprises that entity supports, and described entity supportsComprise that horizontal plane entity supports, axle position entity supports; Described entity is loose structure in the middle of supporting.
Described horizontal plane entity supports has horizontal plane support circular arc.
Described loose structure is micropore porous octahedral structure.
The preparation method that the present invention also provides a kind of 3D to print Bionics Bone trabecularism Cervical Fusion device, bagDraw together following steps:
One, get raw material titanium alloy powder Ti6Al4V powder;
Two, the quick selective melting of electron beam is shaped and makes;
Three, the powder of Material removal fusion device loose structure support, checks and get final product.
Described making is by former electron beam selective melting forming machine, and described material powder is shaped;Described titanium alloy powder Ti6Al4V is 40-100um granularity; This shaping machined parameters: every layer of shaping base plate0.03-0.07mm cuts layer to model, save data; Set initial technological parameter: base plate preheating700 DEG C-800 DEG C of temperature, powder bed preheat curent 8-12mA, preheating time 8-12s, sweep current15～35mA; Supporting construction is implemented discrete scanning, sweep current 12～65mA.
The present invention also provides a kind of 3D of described backbone Cervical anterior fusion fixing operation to print Bionics Bone girderThe application of structure Cervical Fusion device, comprises and supports centrum when carrying out cervical spinal fusion, provides at once steadyQualitative, support normal bone to merge.
The present invention compared with prior art, has following technique effect:
1. the present invention adopts 3D mode to make the loose structure of apery body cancellous bone in the middle of entity supports, and carriesThe support of growing into for bone, promotes ostosis process. Be added with support column in entity support surrounding and side, in order toImprove mechanical property, the elastic modelling quantity that this entity is supported approaches the elastic modelling quantity of contact-making surface, avoids occurringBlock.
2. the present invention does not need to replant into human bone, can further reduce like this bone amount of getting in operation, subtractsFew wound to patient, completes this operation in the mode of Wicresoft.
3. this purposes difference and conventional fusion device, have significant stability advantage.
Brief description of the drawings
Fig. 1 is front view of the present invention
Fig. 2 is top view of the present invention
Fig. 3 is side view of the present invention
Fig. 4 is loose structure schematic diagram of the present invention
1-horizontal plane entity supports, 2-loose structure, and 3-axle position entity supports, and 4-horizontal plane supports circular arc
Detailed description of the invention
The 3D of backbone Cervical anterior fusion fixing operation as shown in Figure 1, Figure 2, Figure 3, Figure 4 prints bionicalTrabecular bone structure Cervical Fusion device, comprises that entity supports, described entity support comprise horizontal plane entity support 1,Axle position entity supports 3; Described horizontal plane entity supports 1 and has horizontal plane support circular arc 4; Described entity supportsCentre is loose structure 2, and described loose structure 2 is micropore porous octahedral structure.
Because product of the present invention edge is entity, centre is loose structure, and loose structure is regular skyBetween octahedra. Cervical vertebral fusion cage adopts the design that meets human cervical spine anatomical structure, adopts in horizontal bedding surroundingStrengthen entity by circle and support, adopt support column arrangement in people's axon position aspect, to improve entire compression contractingEnergy.
3D of the present invention prints the preparation method of Bionics Bone trabecularism Cervical Fusion device, comprises following stepRapid:
1. material powder: titanium alloy powder Ti6Al4V, described titanium alloy powder Ti6Al4V is 40-100umGranularity;
2. electron beam quick Fabrication: by former, as ArcamA2 type electron beam selective melting forming machine,Described material powder is shaped; This shaping machined parameters: shaping base plate size 210mm × 210mm; Every layer0.03-0.07mm, especially selects 0.05mm model to be cut to layer, save data; Set initial processParameter: base plate preheat temperature can be 700 DEG C-800 DEG C, as 730 DEG C, powder bed preheat curent 8-12MA, especially 10mA, preheating time 8-12s, especially 10s, sweep current 15～35mA; Supporting constructionImplement discrete scanning, sweep current 12～65mA.
3. the powder of Material removal fusion device; Inspection, packaging.
The present invention also provides the 3D of described backbone Cervical anterior fusion fixing operation to print Bionics Bone trabecularismThe application of Cervical Fusion device, comprises and supports centrum when carrying out cervical spinal fusion, and Initial stability is provided,Support normal bone fusion process.
The structure of the product porous that the present invention makes is regular space octahedral structure, and porosity ranges is70%-80%, pore diameter range 600-800 μ m. The present invention is taking human body cancellous bone as data model, Accurate MeasurementBetween the each parameter region of Grafting Cancellous Bone Bolt girder, by adjusting bone trabecula aperture, porosity, bone trabecula diameter technique ginsengNumber, realizes the control to bone fusion device pore structure. The support that bone provided by the invention is grown into, promotes bone to send outDescribed in raw process, surrounding or side are provided with support column, have increased the compressive strength of fusion device; Support column has improvedMechanical property, the elastic modelling quantity that this entity is supported approaches the elastic modelling quantity of contact-making surface, does not need to implant againHuman bone, can further reduce the bone amount of getting in operation like this, reduces the wound to patient.

Claims (8)

1. 3D prints a Bionics Bone trabecularism Cervical Fusion device, it is characterized in that: comprise that entity supports,Described entity supports and comprises that horizontal plane entity supports (1), axle position entity supports (3); During described entity supportsBetween be loose structure (2).
2. 3D according to claim 1 prints Bionics Bone trabecularism Cervical Fusion device, its featureBe: described horizontal plane entity supports (1) and has horizontal plane support circular arc (4).
3. 3D according to claim 1 and 2 prints Bionics Bone trabecularism Cervical Fusion device, itsFeature is: described loose structure (2) is micropore porous octahedral structure.
4. the 3D of one of claim 1-3 prints the preparation method of Bionics Bone trabecularism Cervical Fusion device,Comprise the following steps:
One, get raw material titanium alloy powder Ti6Al4V powder;
Two, the quick selective melting of electron beam is shaped and makes;
Three, the powder of Material removal fusion device loose structure support, checks and get final product.
5. 3D according to claim 4 prints the making side of Bionics Bone trabecularism Cervical Fusion deviceMethod, described titanium alloy powder Ti6Al4V is 40-100um granularity; Described in powder, making is to pass through formerElectron beam selective melting forming machine, is shaped described material powder; This shaping machined parameters: shaping base plate is everyLayer 0.03-0.07mm cuts layer to model, save data; Set initial technological parameter: base plate is pre-700 DEG C-800 DEG C of hot temperature degree, powder bed preheat curent 8-12mA, preheating time, 8-12s, scanned electricityStream 15～35mA; Supporting construction is implemented discrete scanning, sweep current 12～65mA.
6. print the system of Bionics Bone trabecularism Cervical Fusion device according to the 3D described in claim 4 or 5Make method, described former is ArcamA2 type electron beam selective melting forming machine.
7. 3D according to claim 5 prints the making side of Bionics Bone trabecularism Cervical Fusion deviceMethod, described shaping machined parameters: shaping base plate size 210mm × 210mm; Every layer of 0.05mm is to modelCut layer, save data; Set initial technological parameter: 730 DEG C of base plate preheat temperatures, powder bedPreheat curent 10mA, preheating time 10s.
8. the 3D of one of claim 1-3 prints the application of Bionics Bone trabecularism Cervical Fusion device, comprisesBe used for supporting centrum while carrying out cervical spinal fusion, Initial stability is provided, support normal bone to merge.
CN201610015538.9A 2016-01-11 2016-01-11 3D print type artificial bone trabecula structure cervical fusion device and preparing method and application thereof Pending CN105581860A (en)

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Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106180708A (en) * 2016-06-30 2016-12-07 浙江工业大学 Metal increases controlled pore reticular supporting structure during material manufactures and preparation method thereof
CN106510906A (en) * 2017-01-01 2017-03-22 常州华森医疗器械有限公司 Supporting structure portion of porous titanium interbody fusion cage
CN106618809A (en) * 2017-01-01 2017-05-10 常州华森医疗器械有限公司 Pore structure part of porous titanium intervertebral fusion cage
CN106667626A (en) * 2017-01-01 2017-05-17 常州华森医疗器械有限公司 Porous titanium interbody fusion cage and method for preparing same
CN106726017A (en) * 2017-01-01 2017-05-31 常州华森医疗器械有限公司 The gap structure portion of POROUS TITANIUM Invasive lumbar fusion device
CN107349034A (en) * 2017-07-31 2017-11-17 深圳维度生物医疗科技有限公司 A kind of POROUS TITANIUM cervical vertebral fusion cage with HA coatings and preparation method thereof
CN110542364A (en) * 2018-12-15 2019-12-06 嘉思特华剑医疗器材(天津)有限公司 Method for measuring wire diameter and aperture of 3D titanium alloy bone trabecula test piece
CN111227994A (en) * 2018-11-28 2020-06-05 财团法人金属工业研究发展中心 Porous biomedical implant and method for producing same
CN113319291A (en) * 2021-04-21 2021-08-31 中国科学院金属研究所 Preparation method of recoverable individualized customized femoral stem based on 4D printing shape
CN114082983A (en) * 2021-11-08 2022-02-25 李鹏 Preparation method of 3D printing spine porous fixing nail rod

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US20100076559A1 (en) * 2007-05-04 2010-03-25 Titan Spine, Llc Composite telescoping anterior interbody spinal implant
US20120185047A1 (en) * 2011-01-17 2012-07-19 Cibor, Inc. Reinforced carbon fiber/carbon foam intervertebral spine fusion device
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CN103074511A (en) * 2012-11-13 2013-05-01 西北有色金属研究院 Medical multi-hole implanted alloy material and preparation method thereof
CN103445883A (en) * 2012-06-04 2013-12-18 合硕生技股份有限公司 Medical hollow-out rack implant
CN104706446A (en) * 2015-03-24 2015-06-17 李鹏 Bionic bone trabecula cervical vertebral fusion cage and manufacturing method thereof
CN204636623U (en) * 2015-01-07 2015-09-16 北京爱康宜诚医疗器材股份有限公司 3D metal embedded bone trabecula intervertebral fusion device
CN205322556U (en) * 2016-01-11 2016-06-22 李鹏 Backbone anterior cervical spine 3D prints bionical bone trabecula structure cervical vertebra and fuses device

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US20100076559A1 (en) * 2007-05-04 2010-03-25 Titan Spine, Llc Composite telescoping anterior interbody spinal implant
CN103068343A (en) * 2010-07-23 2013-04-24 普里韦勒普-施皮内股份公司 Surgical implant
US20120185047A1 (en) * 2011-01-17 2012-07-19 Cibor, Inc. Reinforced carbon fiber/carbon foam intervertebral spine fusion device
CN103445883A (en) * 2012-06-04 2013-12-18 合硕生技股份有限公司 Medical hollow-out rack implant
CN103074511A (en) * 2012-11-13 2013-05-01 西北有色金属研究院 Medical multi-hole implanted alloy material and preparation method thereof
CN204636623U (en) * 2015-01-07 2015-09-16 北京爱康宜诚医疗器材股份有限公司 3D metal embedded bone trabecula intervertebral fusion device
CN104706446A (en) * 2015-03-24 2015-06-17 李鹏 Bionic bone trabecula cervical vertebral fusion cage and manufacturing method thereof
CN205322556U (en) * 2016-01-11 2016-06-22 李鹏 Backbone anterior cervical spine 3D prints bionical bone trabecula structure cervical vertebra and fuses device

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106180708A (en) * 2016-06-30 2016-12-07 浙江工业大学 Metal increases controlled pore reticular supporting structure during material manufactures and preparation method thereof
CN106510906A (en) * 2017-01-01 2017-03-22 常州华森医疗器械有限公司 Supporting structure portion of porous titanium interbody fusion cage
CN106618809A (en) * 2017-01-01 2017-05-10 常州华森医疗器械有限公司 Pore structure part of porous titanium intervertebral fusion cage
CN106667626A (en) * 2017-01-01 2017-05-17 常州华森医疗器械有限公司 Porous titanium interbody fusion cage and method for preparing same
CN106726017A (en) * 2017-01-01 2017-05-31 常州华森医疗器械有限公司 The gap structure portion of POROUS TITANIUM Invasive lumbar fusion device
CN106618809B (en) * 2017-01-01 2019-01-25 常州华森医疗器械有限公司 POROUS TITANIUM Invasive lumbar fusion device
CN107349034A (en) * 2017-07-31 2017-11-17 深圳维度生物医疗科技有限公司 A kind of POROUS TITANIUM cervical vertebral fusion cage with HA coatings and preparation method thereof
CN111227994A (en) * 2018-11-28 2020-06-05 财团法人金属工业研究发展中心 Porous biomedical implant and method for producing same
CN110542364A (en) * 2018-12-15 2019-12-06 嘉思特华剑医疗器材(天津)有限公司 Method for measuring wire diameter and aperture of 3D titanium alloy bone trabecula test piece
CN110542364B (en) * 2018-12-15 2021-07-27 嘉思特华剑医疗器材(天津)有限公司 Method for measuring wire diameter and pore diameter of 3D-printed titanium alloy bone trabecula test piece
CN113319291A (en) * 2021-04-21 2021-08-31 中国科学院金属研究所 Preparation method of recoverable individualized customized femoral stem based on 4D printing shape
CN114082983A (en) * 2021-11-08 2022-02-25 李鹏 Preparation method of 3D printing spine porous fixing nail rod

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