CN105749122A

CN105749122A - Pharmaceutical composition for treating diarrhea and preparation method of pharmaceutical composition

Info

Publication number: CN105749122A
Application number: CN201610209559.4A
Authority: CN
Inventors: 林云权
Original assignee: Individual
Current assignee: Individual
Priority date: 2016-04-05
Filing date: 2016-04-05
Publication date: 2016-07-13

Abstract

The invention provides a pharmaceutical composition for treating diarrhea and a preparation method of the pharmaceutical composition. The pharmaceutical composition for treating diarrhea is prepared by extracting, concentrating, drying, crushing and pelletizing the following raw materials in parts by weight: 1-3 parts of herba portulacae, 2-6 parts of flowers of hyacinth beans, 5-10 parts of rhizoma atractylodis, 5-10 parts of white atractylodes rhizome, 3-6 parts of pericarpium citri reticulatae, 1-3 parts of pinellia ternate, 1-3 parts of mangnolia officinalis, 3-6 parts of fructus amomi, 5-10 parts of amomum cardamomum, 5-10 parts of agastache rugosus, 5-10 parts of herba eupatorii, 3-6 parts of poria cocos, 2-5 parts of amomum tsao-ko, 1-3 parts of alpinia katsumadai, 10-13 parts of ginseng, 11-13 parts of codonopsis pilosula, 1-3 parts of pseudostellaria heterophylla, 1-3 parts of honey-fried licorice roots, 1-3 parts of astragalus membranaceus, 1-3 parts of Chinese yam, 1-3 parts of hyacinth beans and 1-3 parts of lotus seeds. The pharmaceutical composition has the efficacy of quickly relieving the symptoms of diarrhea, and has the characteristics of being scientific in prescription, simple in preparation method, low in processing cost, significant in curative effect and free of any toxic or side effect.

Description

A kind of pharmaceutical composition treating diarrhoea and preparation method thereof

Technical field

The invention belongs to the field of Chinese medicines, be specifically related to a kind of pharmaceutical composition treating diarrhoea and preparation method thereof.

Background technology

Diarrhoea is a kind of common sympton, is commonly called as " diarrhoea ", refers to that defecation frequency is significantly more than the frequency being on ordinary days accustomed to, and excrement matter is thin, and moisture increases, and every day, feces volume was more than 200g, or containing not digesting food or pus and blood, mucus.Diarrhoea is often accompanied by the symptoms such as defecation urgency sense, anus discomfort, incontinence.Acute and chronic two classes of diarrhoea point.Acute diarrhea is fallen ill sharply, and the course of disease is within 2～3 weeks.Chronic diarrhea refers to the recurrent diarrhoea that the course of disease is more than two months or the intermission is in 2～4 weeks.Diarrhoea, except seeing intestinal tract disease, is also described in acute poisoning, systemic infection, and multiple allergic disease.Catch a cold and the unclean common cause being to cause diarrhoea of food.The infectious diseases such as dysentery are also likely to be the more serious cause of disease.Report according to World Health Organization (WHO), the death of child in less than five years old, the whole world has 20 percent to be that the dehydrating phenomena that diarrhoea causes causes.1,800,000 children are had to die from diarrhoea every year.

Doctor trained in Western medicine, for the treatment of diarrhoea, is generally adopted antiinflammatory, anti-infectives and antiviral drugs coupling, has certain side effect, human body has very big injury.Chinese medicine is thought, " has loose bowels originally, invariably due to taste." sick many because of being invaded by exogenous pathogen, such as the heresy of damp and hot, heat-damp in summer, cold-damp；Feelings will is hindered, and anxiety and rage causes the liver failing to maintain the normal flow of QI, and perverse and unreasonable manner criminal's spleen forms has loose bowels；Eating and drinking without temperance, surfeit delicious food savoury, or the thing of unclean corruption of taking food.The prescription of Chinese traditional treatment diarrhoea is various, the specific aim of each prescription is different, and the decoction of Chinese medicine decoction and taking all is inconvenient for, decocting time brings very big impact with taking improper meeting to treatment, it is thus desirable to one can either effectively treat symptom of diarrhea, the medicine can conveniently taken again is to solve patient suffering.

Summary of the invention

In order to overcome above-mentioned prior art defect, it is an object of the invention to provide a kind of pharmaceutical composition treating diarrhoea and preparation method thereof, from motherland's medical treasure-house, according to traditional Chinese medical science prescription theory, skim the cream off milk, reconfigure, its drug-specific is made to work for symptom of diarrhea, play effect for the treatment of diarrhoea, adopt modern pharmaceutical means, there is prescription science, preparation method is simple, processing cost is low, evident in efficacy, without any side effects feature.

In order to solve above-mentioned technical problem, the present invention takes following technical scheme:

A kind of pharmaceutical composition treating diarrhoea, including: Herba Portulacae, Flos dolichoris, Rhizoma Atractylodis, the Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae, the Rhizoma Pinelliae, Cortex Magnoliae Officinalis, Fructus Amomi, roud cardamon seed, Herba Pogostemonis, Herba Eupatorii, Poria, Fructus Tsaoko, Semen Alpiniae Katsumadai, Radix Ginseng, Radix Codonopsis, Radix Ginseng, Radix Glycyrrhizae Preparata, the Radix Astragali, Rhizoma Dioscoreae, Seem Lablab Album.

Further, a kind of pharmaceutical composition treating diarrhoea, its raw material constituent also includes: Semen Nelumbinis.

Further, a kind of pharmaceutical composition treating diarrhoea, its raw material weight constituent is: Herba Portulacae 1～3 part, Flos dolichoris 2～6 parts, Rhizoma Atractylodis 5～10 parts, the Rhizoma Atractylodis Macrocephalae 5～10 parts, Pericarpium Citri Reticulatae 3～6 parts, the Rhizoma Pinelliae 1～3 part, Cortex Magnoliae Officinalis 1～3 part, Fructus Amomi 3～6 parts, roud cardamon seed 5～10 parts, Herba Pogostemonis 5～10 parts, Herba Eupatorii 5～10 parts, 3～6 parts of Poria, Fructus Tsaoko 2～5 parts, Semen Alpiniae Katsumadai 1～3 part, Radix Ginseng 10～13 parts, Radix Codonopsis 11～13 parts, Radix Ginseng 1～3 part, Radix Glycyrrhizae Preparata 1～3 part, the Radix Astragali 1～3 part, Rhizoma Dioscoreae 1～3 part, 1～3 part of Seem Lablab Album, 1～3 part of Semen Nelumbinis.

Further, a kind of pharmaceutical composition treating diarrhoea, its raw material weight optimum constituent is:

Herba Portulacae 1 part, Flos dolichoris 2 parts, Rhizoma Atractylodis 5 parts, the Rhizoma Atractylodis Macrocephalae 6 parts, Pericarpium Citri Reticulatae 3 parts, the Rhizoma Pinelliae 2 parts, Cortex Magnoliae Officinalis 1 part, Fructus Amomi 4 parts, roud cardamon seed 7 parts, Herba Pogostemonis 8 parts, Herba Eupatorii 9 parts, 4 parts of Poria, Fructus Tsaoko 5 parts, Semen Alpiniae Katsumadai 3 parts, Radix Ginseng 10 parts, Radix Codonopsis 11 parts, Radix Ginseng 2 parts, Radix Glycyrrhizae Preparata 1 part, the Radix Astragali 2 parts, Rhizoma Dioscoreae 3 parts, 2 parts of Seem Lablab Album, 1 part of Semen Nelumbinis.

Wherein, the primarily serving the purpose of of said herbal medicine composition:

Herba Portulacae sour in the mouth is cold in nature, energy clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body.For bacillary dysentery, acute gastroenteritis, acute appendicitis, mastitis, bleeding hemorrhoids, leucorrhea；Furuncle swelling toxin, eczema, herpes zoster are controlled in external.

Flos dolichoris is put down, and slightly sweet flavor is nontoxic；Return spleen, stomach, large intestine channel；Energy expelling summer-heat and damp and middle spleen invigorating, main summer Sunstroke wets, heating, has loose bowels, dysentery, leucorrhea with red and white discharge, and traumatic injury wound is swollen.

Rhizoma Atractylodis acrid in the mouth, hardship, warm in nature, return spleen, stomach, Liver Channel, can be drying damp and strengthening spleen, expelling wind and cold, improving eyesight；For distension and fullness in the abdomen, have loose bowels, edema, beriberi flaccidity, rheumatic arthralgia, anemofrigid cold, nyctalopia.

Rhizoma Atractylodis Macrocephalae bitter in the mouth, sweet, warm in nature, return spleen, stomach warp, can invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.

Pericarpium Citri Reticulatae bitter in the mouth, sweet, warm in nature, return lung, spleen channel, can regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.For fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm.

Rhizoma Pinelliae acrid in the mouth, warm in nature, poisonous, return spleen, stomach, lung meridian, energy drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass.For abundant expectoration cough with asthma, phlegm retention vertigo and palpitation, dizziness due to wind-phlegm, syncope due to accumulation of phlegm is had a headache, and vomits regurgitation, and breast gastral cavity painful abdominal mass is vexed, globus hystericus；Raw with external treatment carbuncle sucutaneous nodule.

Cortex Magnoliae Officinalis bitter in the mouth, pungent, warm in nature, return spleen, stomach, lung, large intestine channel, can dampness expectorant, the therapeutic method to keep the adverse QI flowing downwards is except full.For humidity hysteresis damaging the spleen and stomach, gastral cavity painful abdominal mass is vomited and diarrhoea, and stagnation of QI due to dyspepsia, abdominal distention constipation, phlegm retention is breathed with cough.

Fructus Amomi bitter in the mouth, warm in nature, return spleen, stomach, kidney channel, can removing dampness whet the appetite, warming spleen and stopping diarrha, regulate the flow of vital energy antiabortive.For turbid damp obstructing in middle-JIAO, gastral cavity painful abdominal mass is not hungry, Deficiency and coldness of spleen and stomach, and vomiting is had loose bowels, pregnancy reactions, frequent fetal movement.

Fructus Amomi Rotundus acrid in the mouth, warm in nature, return lung, spleen, stomach warp, can removing dampness circulation of qi promoting, warming middle-JIAO to arrest vomiting, appetite-stimulating indigestion-relieving.Main retention of damp leading to blockage of QI, incoordination between the spleen and stomach, distension and fullness in the abdomen, anorexia, hygropyrexia from the beginning of, uncomfortable in chest not hungry, gastrofrigid vomiting, food stagnation does not disappear.

Herba Pogostemonis acrid in the mouth, slightly warm in nature, return lung, spleen, stomach warp, can dispelling summer-heat from superficies of the body, removing dampness to restore normal function of the stomach.Flu of main summertime, cold and heat are had a headache, breast gastral cavity painful abdominal mass is vexed, vomiting is had loose bowels, vomiting during pregnancy, nasal sinusitis, tinea manus and pedis.

Herba Eupatorii acrid in the mouth, property is put down, and returns spleen, stomach, lung meridian, can removing dampness by means of aromatics, appetizing of being amusing, deliver expelling summer-heat.Uncomfortable in chest for sweet in turbid damp obstructing in middle-JIAO, gastral cavity painful abdominal mass vomiting and nausea, mouth greasy, halitosis, sialism, heat-damp in summer table disease, feeling of fullness in the head.

Radix Ginseng: sweet in the mouth, micro-hardship, property is put down；Return spleen, lung, heart channel；Strongly invigorating primordial QI, multiple arteries and veins takes off admittedly, and invigorating the spleen to benefit the lung promotes the production of body fluid, calms the nerves.Radix Codonopsis is put down, and sweet in the mouth has the ability of invigorating the spleen and replenishing QI, spleen invigorating lung benefiting, has the effect of Gastrointestinal motility adjustment, antiulcer, gastric acid secretion inhibiting, reduction pepsin activity.

Poria sweet in the mouth, light, property is put down, GUIXIN, lung, spleen, kidney channel, can promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.For edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability, palpitation with fear insomnia.

Fructus Tsaoko acrid in the mouth, warm in nature, return spleen, stomach warp, can dampness warming middle-JIAO, expectorant preventing the attack (or recurrence) of malaria.For internal retention of cold wetness, abdominal distention, feeling of fullness is vomitted, malaria cold and heat.

Semen Alpiniae Katsumadai acrid in the mouth, warm in nature, return spleen, stomach warp, can be drying damp and strengthening spleen, stomach warming preventing or arresting vomiting.For internal retention of cold wetness, distension and fullness in the abdomen cold type of pain, belch vomiting, anorexia.

Radix Codonopsis sweet in the mouth, property are flat, return spleen, lung meridian, energy invigorating the spleen and replenishing QI, spleen invigorating lung benefiting.For deficiency of the spleen and lung, cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency is coughed, and interior-heat is quenched one's thirst.

Radix Ginseng sweet in the mouth, micro-hardship, property is put down, and returns spleen, lung meridian, energy replenishing QI to invigorate the spleen, promoting the production of body fluid for nourishing the lung.Tired for insufficiency of the spleen body, inappetence, weak after being ill, deficiency of both vital energy and Yin, spontaneous perspiration is thirsty, dryness of the lung dry cough.

Radix Glycyrrhizae Preparata sweet in the mouth, property are flat, GUIXIN, lung, spleen, stomach warp, energy spleen reinforcing stomach function regulating, Yiqi and vein recovery.For weakness of the spleen and stomach, fatigue and weakness, severe palpitation, irregularly intermittent and regularly intermittent pulse.

The Radix Astragali is warm in nature, sweet in the mouth, energy invigorating QI to consolidate the body surface resistance, expelling pus and toxin by strengthening QI, diuresis, granulation promoting., chronic diarrhea proctoptosis, spontaneous perspiration, edema weak for the deficiency of vital energy, sub-official prolapsus, chronic nephritis proteinuria, diabetes, open sore part disunion of a specified duration.

Rhizoma Dioscoreae sweet in the mouth is put down, and returns spleen, lung, kidney channel, and energy spleen reinforcing nourishing the stomach, promote the production of body fluid lung benefiting, the kidney invigorating arresting seminal emission.For insufficiency of the spleen lack of appetite, incessant chronic diarrhea, the deficiency of the lung is breathed with cough, emission due to deficiency of the kidney, leukorrhagia, frequent micturition, and deficiency-heat is quenched one's thirst.Rhizoma Dioscoreae (parched with bran) spleen reinforcing stomach invigorating.For insufficiency of the spleen lack of appetite, loose stool of having loose bowels, leukorrhagia.

Seem Lablab Album sweet in the mouth is put down, and enters spleen, stomach warp, can spleen invigorating and in, removing dampness of relieving summer heat.Controlling heat-damp in summer to vomit and diarrhoea, insufficiency of the spleen vomiting, lack of appetite chronic diarrhea, water retention is quenched one's thirst, leucorrhea with red and white discharge, infantile malnutrition.

Wherein, the primarily serving the purpose of of the medicinal herb components of above-mentioned interpolation:

Semen Nelumbinis sweet in the mouth, puckery, property is put down, and returns spleen, kidney, heart channel, can tonifying spleen and stopping diarrhea, kidney tonifying arresting seminal emission, tranquilizing by nourishing the heart.For insufficiency of the spleen chronic diarrhea, leukorrhagia of passing out semen, palpitation and insomnia.

Further object is that the preparation method that described Chinese medicine composition is provided, comprise the following steps:

The first step, by extracting in water after Herba Portulacae, Flos dolichoris, Rhizoma Atractylodis, the Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae, the Rhizoma Pinelliae, Cortex Magnoliae Officinalis, Fructus Amomi, roud cardamon seed, Herba Pogostemonis, Herba Eupatorii, Poria, Fructus Tsaoko, Semen Alpiniae Katsumadai, Radix Ginseng, Radix Codonopsis, Radix Ginseng, Radix Glycyrrhizae Preparata, Radix Astragali co-grinding, filtering, extracting solution is standby.

Second step, the extracting solution that the first step is obtained through dried, and Rhizoma Dioscoreae 1～3 part, 1～3 part of Seem Lablab Album, 1～3 part of co-grinding of Semen Nelumbinis, add adjuvant, granulate, make required dosage form.

Further, in the first step, the condition pulverized after described Herba Portulacae, Flos dolichoris, Rhizoma Atractylodis, the Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae, the Rhizoma Pinelliae, Cortex Magnoliae Officinalis, Fructus Amomi, roud cardamon seed, Herba Pogostemonis, Herba Eupatorii, Poria, Fructus Tsaoko, Semen Alpiniae Katsumadai, Radix Ginseng, Radix Codonopsis, Radix Ginseng, Radix Glycyrrhizae Preparata, Radix Astragali mixing is: the medicinal mixture after pulverizing crosses 20 mesh sieves, pulverized and be slightly unfavorable for extracting, it is meticulous to pulverize, and extracting solution thickness is unfavorable for filtering.

Further, in the first step, after described medicament mixed is pulverized, the method for extracting in water is: the pure water adding 10 times extracts 5～8 hours when 100 DEG C.

Further, in second step, the mode that described extracting solution dries is: spray drying, or constant-pressure and high-temperature dries.

Further, in second step, extracting solution through super-dry, pulverize after particle diameter between 10～25 μm.

Further, in second step, the dosage form of described pharmaceutical composition is granule, pill, soft capsule, capsule, tablet.

The invention have the advantage that

The pharmaceutical composition for the treatment of diarrhoea disclosed by the invention, for pure Chinese medicinal preparation, in conjunction with modern pharmaceutical technique, the basis of ancient prescription is revised, makes curative effect rapider, prescription is simplified, preparation method is simple, processing cost is low, evident in efficacy, without any side effects, the efficacy of a drug is strong, instant effect, can eliminate rapidly symptom of diarrhea, adopt modern crafts pharmacy, conveniently take.

Detailed description of the invention

Specific embodiments of the invention given below, are used for the present invention is described in further detail.

Experimental technique in following embodiment, if no special instructions, is conventional method.Medicinal raw material used in following embodiment, reagent material etc., if no special instructions, be commercially available purchase product.

Embodiment 1

A kind of pharmaceutical composition treating diarrhoea

Crude drug forms: (unit: g)

Herba Portulacae 10, Flos dolichoris 20, Rhizoma Atractylodis 50, the Rhizoma Atractylodis Macrocephalae 60, Pericarpium Citri Reticulatae 30, the Rhizoma Pinelliae 20, Cortex Magnoliae Officinalis 10, Fructus Amomi 40, roud cardamon seed 70, Herba Pogostemonis 80, Herba Eupatorii 90, Poria 40, Fructus Tsaoko 50, Semen Alpiniae Katsumadai 30, Radix Ginseng 100, Radix Codonopsis 110, Radix Ginseng 20, Radix Glycyrrhizae Preparata 10, the Radix Astragali 20, Rhizoma Dioscoreae 30, Seem Lablab Album 20, Semen Nelumbinis 10.

It is prepared via a method which:

(1) extract adding the pure water of 8.6kg after Herba Portulacae, Flos dolichoris, Rhizoma Atractylodis, the Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae, the Rhizoma Pinelliae, Cortex Magnoliae Officinalis, Fructus Amomi, roud cardamon seed, Herba Pogostemonis, Herba Eupatorii, Poria, Fructus Tsaoko, Semen Alpiniae Katsumadai, Radix Ginseng, Radix Codonopsis, Radix Ginseng, Radix Glycyrrhizae Preparata, Radix Astragali co-grinding 6 hours when 100 DEG C, filtering, extracting solution is standby；

(2) by Rhizoma Dioscoreae 30g, Seem Lablab Album 20g, Semen Nelumbinis 10g co-grinding, the extracting solution obtained with (1) powder of spray drying when inlet temperature 210 DEG C, pan feeding flow 70mL/min, shower nozzle rotating speed 30000r/min mixes, and obtains particle diameter powder 189g between 10～25 μm；According to drug powder: starch: the ratio of sucrose=3:1:1 adds starch 63g, sucrose 63g, mix homogeneously, granulates, makes granule, subpackage, every bag of 5g, there are granule 63 bags.

Embodiment 2

A kind of pharmaceutical composition treating diarrhoea

Crude drug forms: (unit: g)

Herba Portulacae 10, Flos dolichoris 20, Rhizoma Atractylodis 50, the Rhizoma Atractylodis Macrocephalae 50, Pericarpium Citri Reticulatae 30, the Rhizoma Pinelliae 10, Cortex Magnoliae Officinalis 10, Fructus Amomi 30, roud cardamon seed 50, Herba Pogostemonis 50, Herba Eupatorii 50, Poria 30, Fructus Tsaoko 20, Semen Alpiniae Katsumadai 10, Radix Ginseng 100, Radix Codonopsis 110, Radix Ginseng 10, Radix Glycyrrhizae Preparata 10, the Radix Astragali 10, Rhizoma Dioscoreae 10, Seem Lablab Album 10, Semen Nelumbinis 10.

It is prepared via a method which:

(1) extract adding the pure water of 6.9kg after Herba Portulacae, Flos dolichoris, Rhizoma Atractylodis, the Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae, the Rhizoma Pinelliae, Cortex Magnoliae Officinalis, Fructus Amomi, roud cardamon seed, Herba Pogostemonis, Herba Eupatorii, Poria, Fructus Tsaoko, Semen Alpiniae Katsumadai, Radix Ginseng, Radix Codonopsis, Radix Ginseng, Radix Glycyrrhizae Preparata, Radix Astragali co-grinding 5 hours when 100 DEG C, filtering, extracting solution is standby；

(2) extracting solution (1) obtained is when normal pressure temperature is 95 DEG C, is condensed into dry cream, pulverizes, mixes with Rhizoma Dioscoreae 10g, Seem Lablab Album 10g, Semen Nelumbinis 10g, obtains particle diameter powder 134g between 10～25 μm through pulverizing；Add 70% appropriate amount of ethanol, dry 1 hour with the temperature of 60 DEG C after mixing thoroughly, granulate, dry 1.5 hours with the temperature of 70 DEG C, after drying by medicinal powder mixture powder through the encapsulated process of granulator, every encapsulated 400mg, obtain capsule 335.

Embodiment 3

A kind of pharmaceutical composition treating diarrhoea

Crude drug forms: (unit: kg)

Herba Portulacae 30, Flos dolichoris 60, Rhizoma Atractylodis 100, the Rhizoma Atractylodis Macrocephalae 100, Pericarpium Citri Reticulatae 60, the Rhizoma Pinelliae 30, Cortex Magnoliae Officinalis 30, Fructus Amomi 60, roud cardamon seed 100, Herba Pogostemonis 100, Herba Eupatorii 100, Poria 60, Fructus Tsaoko 50, Semen Alpiniae Katsumadai 30, Radix Ginseng 130, Radix Codonopsis 130, Radix Ginseng 30, Radix Glycyrrhizae Preparata 30, the Radix Astragali 30, Rhizoma Dioscoreae 30, Seem Lablab Album 30, Semen Nelumbinis 30.

It is prepared via a method which:

(1) extract adding the pure water of 12600kg after Herba Portulacae, Flos dolichoris, Rhizoma Atractylodis, the Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae, the Rhizoma Pinelliae, Cortex Magnoliae Officinalis, Fructus Amomi, roud cardamon seed, Herba Pogostemonis, Herba Eupatorii, Poria, Fructus Tsaoko, Semen Alpiniae Katsumadai, Radix Ginseng, Radix Codonopsis, Radix Ginseng, Radix Glycyrrhizae Preparata, Radix Astragali co-grinding 8 hours when 100 DEG C, filtering, extracting solution is standby；

(2) extracting solution Rhizoma Dioscoreae 30kg, Seem Lablab Album 30kg, Semen Nelumbinis 30kg obtained with (1) through micronizing powder after inlet temperature 205 DEG C, pan feeding flow 65mL/min, shower nozzle rotating speed 25000r/min spray drying mixes, pulverize, obtain particle diameter powder 279kg between 10～25 μm, add 75% appropriate amount of ethanol, granulate, dry 1.5 hours with the temperature of 80 DEG C, after drying medicinal mixture powder is processed through tabletting machine, every 600mg, obtains medicine 465000.

Embodiment 4

A kind of pharmaceutical composition treating diarrhoea

Crude drug forms: (unit: g)

Herba Portulacae 20, Flos dolichoris 40, Rhizoma Atractylodis 75, the Rhizoma Atractylodis Macrocephalae 75, Pericarpium Citri Reticulatae 45, the Rhizoma Pinelliae 20, Cortex Magnoliae Officinalis 20, Fructus Amomi 45, roud cardamon seed 75, Herba Pogostemonis 75, Herba Eupatorii 75, Poria 45, Fructus Tsaoko 35, Semen Alpiniae Katsumadai 20, Radix Ginseng 115, Radix Codonopsis 115, Radix Ginseng 20, Radix Glycyrrhizae Preparata 20, the Radix Astragali 20, Rhizoma Dioscoreae 20, Seem Lablab Album 20, Semen Nelumbinis 20.

It is prepared via a method which:

(1) extract adding the pure water of 9550g after Herba Portulacae, Flos dolichoris, Rhizoma Atractylodis, the Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae, the Rhizoma Pinelliae, Cortex Magnoliae Officinalis, Fructus Amomi, roud cardamon seed, Herba Pogostemonis, Herba Eupatorii, Poria, Fructus Tsaoko, Semen Alpiniae Katsumadai, Radix Ginseng, Radix Codonopsis, Radix Ginseng, Radix Glycyrrhizae Preparata, Radix Astragali co-grinding 6.5 hours when 100 DEG C, filtering, extracting solution is standby；

(2) extracting solution that Rhizoma Dioscoreae 20g, Seem Lablab Album 20g, Semen Nelumbinis 20g obtain through micronizing and (1) is obtained drug powder 203.25g at inlet temperature 200 DEG C, pan feeding flow 60mL/min, shower nozzle rotating speed 35000r/min spray drying；Addition Cera Flava, hydrogenated palm oil, soybean phospholipid are sufficiently stirred for, and mix homogeneously stands, evacuation, treats that in medicinal liquid, bubble is removed substantially, with the glue pelleting changed, every dress 400mg compacting, obtain soft capsule 1000.

Embodiment 5

A kind of pharmaceutical composition treating diarrhoea

Crude drug forms: (unit: kg)

Herba Portulacae 25, Flos dolichoris 45, Rhizoma Atractylodis 70, the Rhizoma Atractylodis Macrocephalae 70, Pericarpium Citri Reticulatae 40, the Rhizoma Pinelliae 25, Cortex Magnoliae Officinalis 25, Fructus Amomi 40, roud cardamon seed 70, Herba Pogostemonis 70, Herba Eupatorii 70, Poria 40, Fructus Tsaoko 30, Semen Alpiniae Katsumadai 25, Radix Ginseng 110, Radix Codonopsis 110, Radix Ginseng 25, Radix Glycyrrhizae Preparata 25, the Radix Astragali 25, Rhizoma Dioscoreae 25, Seem Lablab Album 25, Semen Nelumbinis 25.

It is prepared via a method which:

(1) extract adding the pure water of 9400kg after Herba Portulacae, Flos dolichoris, Rhizoma Atractylodis, the Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae, the Rhizoma Pinelliae, Cortex Magnoliae Officinalis, Fructus Amomi, roud cardamon seed, Herba Pogostemonis, Herba Eupatorii, Poria, Fructus Tsaoko, Semen Alpiniae Katsumadai, Radix Ginseng, Radix Codonopsis, Radix Ginseng, Radix Glycyrrhizae Preparata, Radix Astragali co-grinding 7.5 hours when 100 DEG C, filtering, extracting solution is standby；

(2) extracting solution (1) obtained, when normal pressure temperature is 95 DEG C, is condensed into dry cream, with Rhizoma Dioscoreae 25kg, Seem Lablab Album 25kg, Semen Nelumbinis 25kg through micronizing, obtains particle diameter powder 216kg between 10～25 μm；Add Mel 108kg, prepare the pill 3240 of every 10g through molding, molding, capping.

Experimental example 1

The animal acute toxicity test of the Chinese medicine composition of the present invention

The present embodiment 2 mensuration by Mouse oral administration medicine median lethal dose(LD 50), has investigated the Chinese medicine composition of embodiment 2 preparation to the acute toxic reaction of mice and death condition.

Take mice 30, often group 10, points 3 groups, i.e. high, medium and low 3 dosage groups (0.8,0.4,0.2ml/15g) gastric infusion 3 times/day, it was predicted that the scope of Calculating Median Lethal Dose of Drugs.Result shows, high dose group does not measure median lethal dose(LD 50), therefore the mensuration of medicine gastric infusion median lethal dose(LD 50) is changed and do the maximum mensuration doing some maximum tolerated dose of maximum volume purgation.

Take mice 30, on an empty stomach after 12 hours, to predict that selected 0.8ml/15g measures by only gastric infusion to animal subject 3 times/day, Continuous Observation 7 days.

Giving by test product 24 hours in gavage, mice voluntary activity declines, and ingests, takes the photograph water and reduce；Within second day, voluntary activity tends to normal gradually, stool, urine no abnormality seen, and mice activity, food ration, body weight growth, feces etc. are all normal, observes test mice after expiring and all survives.

Observe and put to death whole test mice gross necropsy after expiring, it has been found that each important organ, change without obvious pathomorphism such as the heart, liver, spleen, lung, kidney, ovary, intestinal, stomach etc..

The maximum dosage-feeding result of the test of medicine gastric infusion shows: all without obvious toxic reaction after 30 mice administrations, also without dead in one week.It is 73.9g/kg d to recording maximum tolerated dose after mouse stomach administration medicine, become human oral dosage form 8.0g/60kg to calculate as pressed clinic, then the mice of this medicine gavage maximum tolerated dose on the one is [(73.9g/kg) ÷ (8.0g/60kg) ≈ 554] times of clinical adult oral dose on the one.Illustrate that the safety of Chinese medicine composition of the present invention is good.

Experimental example 2

The clinical observation on the therapeutic effect of medicine of the present invention

1, physical data

Accept out-patient's totally 120 example, less than 25 years old age, 20 examples, 26～55 years old 76 example, more than 56 years old 24 examples for medical treatment.

2, diagnostic criteria

The classical symptom of diarrhoea be defecation frequency significantly more than the frequency being on ordinary days accustomed to, excrement matter is thin, and moisture increases, and every day, feces volume was more than 200g, or containing not digesting food or pus and blood, mucus.

Diarrhoea is often accompanied by the symptoms such as defecation urgency sense, anus discomfort, incontinence.

3, Therapeutic Method

Select above-mentioned experimental example 1 medicament, take to patient, every day 3 times, each 1 dose, decoction being taken warmly at twice.Within 1 day, it is a course for the treatment of, takes two courses for the treatment of continuously.

4, efficacy assessment standard

Effective: symptom of diarrhea disappears, defecation frequency and discharge feces recover normal；

Taking a turn for the better: symptom of diarrhea alleviates, defecation frequency reduces, and moisture in feces reduces；

Invalid: not reach improvement standard person.

5, therapeutic outcome (see following table):

In above-mentioned treatment, by Drug therapy diarrhea patient 120 example of the present invention, effective 102 examples of result, obvious effective rate is 85%, and take a turn for the better 15 examples, and improvement rate is 12.5%, invalid 3 examples, and total effective rate is 97.5%.

In a word, a kind of pharmaceutical composition treating diarrhoea of the present invention, for pure Chinese medicinal preparation, prescription is simplified, preparation method is simple, processing cost is low, evident in efficacy, without any side effects, the efficacy of a drug is strong, instant effect, can eliminate rapidly symptom of diarrhea, adopt modern crafts pharmacy, the feature conveniently taken.

These are only the preferred embodiments of the present invention and experimental example, be not limited to the present invention, for a person skilled in the art, the present invention can have various modifications and variations.All within the spirit and principles in the present invention, any amendment of making, equivalent replacement, improvement etc., should be included within protection scope of the present invention.

Claims

1. the pharmaceutical composition treating diarrhoea, it is characterized in that, extract including following components and form: Herba Portulacae 1～3 part, Flos dolichoris 2～6 parts, Rhizoma Atractylodis 5～10 parts, the Rhizoma Atractylodis Macrocephalae 5～10 parts, Pericarpium Citri Reticulatae 3～6 parts, the Rhizoma Pinelliae 1～3 part, Cortex Magnoliae Officinalis 1～3 part, Fructus Amomi 3～6 parts, roud cardamon seed 5～10 parts, Herba Pogostemonis 5～10 parts, Herba Eupatorii 5～10 parts, 3～6 parts of Poria, Fructus Tsaoko 2～5 parts, Semen Alpiniae Katsumadai 1～3 part, Radix Ginseng 10～13 parts, Radix Codonopsis 11～13 parts, Radix Ginseng 1～3 part, Radix Glycyrrhizae Preparata 1～3 part, the Radix Astragali 1～3 part, Rhizoma Dioscoreae 1～3 part, 1～3 part of Seem Lablab Album.

2. pharmaceutical composition according to claim 1, it is characterised in that its pharmaceutical composition component also includes: 1～3 part of Semen Nelumbinis.

3. pharmaceutical composition according to claim 2, it is characterized in that, its pharmaceutical composition weight portion consists of: Herba Portulacae 1 part, Flos dolichoris 2 parts, Rhizoma Atractylodis 5 parts, the Rhizoma Atractylodis Macrocephalae 6 parts, Pericarpium Citri Reticulatae 3 parts, the Rhizoma Pinelliae 2 parts, Cortex Magnoliae Officinalis 1 part, Fructus Amomi 4 parts, roud cardamon seed 7 parts, Herba Pogostemonis 8 parts, Herba Eupatorii 9 parts, 4 parts of Poria, Fructus Tsaoko 5 parts, Semen Alpiniae Katsumadai 3 parts, Radix Ginseng 10 parts, Radix Codonopsis 11 parts, Radix Ginseng 2 parts, Radix Glycyrrhizae Preparata 1 part, the Radix Astragali 2 parts, Rhizoma Dioscoreae 3 parts, 2 parts of Seem Lablab Album, 1 part of Semen Nelumbinis.

4. the preparation method of a pharmaceutical composition as claimed in claim 2, it is characterised in that preparation method is as follows:

The first step, extract adding the pure water of 10 times after Herba Portulacae 1～3 part, Flos dolichoris 2～6 parts, Rhizoma Atractylodis 5～10 parts, the Rhizoma Atractylodis Macrocephalae 5～10 parts, Pericarpium Citri Reticulatae 3～6 parts, the Rhizoma Pinelliae 1～3 part, Cortex Magnoliae Officinalis 1～3 part, Fructus Amomi 3～6 parts, roud cardamon seed 5～10 parts, Herba Pogostemonis 5～10 parts, Herba Eupatorii 5～10 parts, 3～6 parts of Poria, Fructus Tsaoko 2～5 parts, Semen Alpiniae Katsumadai 1～3 part, Radix Ginseng 10～13 parts, Radix Codonopsis 11～13 parts, Radix Ginseng 1～3 part, Radix Glycyrrhizae Preparata 1～3 part, 1～3 part of co-grinding of the Radix Astragali 5～8 hours when 100 DEG C, filtering, extracting solution is standby；

5. preparation method according to claim 4, it is characterized in that, in the first step, the condition that described Herba Portulacae, Flos dolichoris, Rhizoma Atractylodis, the Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae, the Rhizoma Pinelliae, Cortex Magnoliae Officinalis, Fructus Amomi, roud cardamon seed, Herba Pogostemonis, Herba Eupatorii, Poria, Fructus Tsaoko, Semen Alpiniae Katsumadai, Radix Ginseng, Radix Codonopsis, Radix Ginseng, Radix Glycyrrhizae Preparata, the Radix Astragali are pulverized after mixing is: the medicinal mixture after pulverizing crosses 20 mesh sieves.

6. preparation method according to claim 4, it is characterised in that in second step, extracting solution particle diameter after dried and Rhizoma Dioscoreae, Seem Lablab Album, Semen Nelumbinis co-grinding is between 10～25 μm.

7. preparation method according to claim 4, it is characterised in that in second step, the mode that described extracting solution dries is: spray drying, or constant-pressure and high-temperature dries.

8. preparation method according to claim 4, it is characterised in that in second step, the dosage form of described pharmaceutical composition is granule, pill, soft capsule, capsule, tablet.