CN102755635A - Composition for improving gastrointestinal function and preparation method thereof - Google Patents
Composition for improving gastrointestinal function and preparation method thereof Download PDFInfo
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- CN102755635A CN102755635A CN2012102640287A CN201210264028A CN102755635A CN 102755635 A CN102755635 A CN 102755635A CN 2012102640287 A CN2012102640287 A CN 2012102640287A CN 201210264028 A CN201210264028 A CN 201210264028A CN 102755635 A CN102755635 A CN 102755635A
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- eucalyptus globulus
- fructus anisi
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Abstract
The invention discloses a composition for improving the gastrointestinal function and a preparation method thereof, which belong to the field of Chinese medicines. Active ingredients are prepared by combining raw materials including giant typhonium rhizome, coelogyne cristata, truestar anisetree, abroma angusta, folium eucalypti and fishbone polypeptide, and an oral preparation is prepared from the active ingredients and common medicinal preparation auxiliary materials; and the composition has the treatment effect of improving the gastrointestinal function.
Description
Technical field
The present invention relates to a kind of is raw material with Chinese crude drug and fishbone polypeptide, has the compositions of improving gastrointestinal function, belongs to the field of Chinese medicines.
Technical background
Behind the human body dietary intake, gastrointestinal tract is the main position to food digestion and absorption of nutrient ingredients; Stomach is in the digestive system food to be played the organ that hoards food and tentatively digest, and small intestinal is to digest and assimilate significant points in the digestive tract, and excretory various digestive enzyme, Digestive system are to deeply being digested and assimilated by food in the small intestinal, and main nutrient matter absorbs at this.
After human intake's food, except that some small-molecule substances can directly be absorbed by human body, macromolecular substances such as protein, sugar, fat etc. could be absorbed by gastrointestinal mucosal after all needing in digestive tract, to be broken down into small-molecule substance mostly; The acid digestion liquid that gastric is secreted promotes food digestion to absorb, and gastric juice mainly comprises hydrochloric acid, pepsin and mucus etc.; The excretory intestinal fluid of the enteraden of mucous membrane of small intestine contains multiple digestive enzyme, sugar, fat, proteopepsis becomes can be by the material of intestinal absorption.
After human intake's food, if gastrointestinal function normally digest and assimilate normal, nutritional sufficiency; If gastrointestinal dysfunction will cause a series of diseases, like dyspepsia, abdominal distention, diarrhoea, constipation etc., thereby nutrient substance lacks the disease that causes other; So gastrointestinal function normally is one of key factor of health.
Chinese invention patent publication number CN101450074 discloses " a kind of obvious gastrointestinal function, anti-compositions that treats constipation improved "; Adopt oligomeric xylose, biological calcium carbonate, vitamin C, milk flavour preparation; This composition is the combination of main functional component with oligomeric xylose, and effect mainly embodies the defecating feces excretion that improves gastrointestinal function.Chinese invention patent publication number CN1302564A discloses " a kind of method for preparing of improving health food and this health food of gastrointestinal function and beauty treatment ", adopts Radix Angelicae Sinensis, Radix Paeoniae Rubra, Poria, Flos Carthami, Aloe, vitamin E, vitamin B
2For raw material through pulverize, sieve, prepared such as mixing, fill capsule, though have certain effect to improving gastrointestinal function and beauty treatment, encapsulated with the Chinese crude drug crude drug, gastrointestinal is had certain stimulation.Chinese invention patent publication number CN102362970A discloses " a kind of Chinese medicine composition and preparation technology thereof who improves gastrointestinal function ", and adopting Aloe, Radix Angelicae Sinensis, Radix Ophiopogonis, Fructus Aurantii is feedstock production, is primarily aimed at the not normal constipation symptom of gastrointestinal function.
What the present invention was that screening obtains from Chinese crude drug has a Chinese medicine composition that improves action of enterogastric function, with the fishbone polypeptides in combination, reaches and has enhance gastrointestinal power, the effect that facilitating digestion absorbs; Compare with Western medicine, it is little to have toxic and side effects, and the advantage that is suitable for taking for a long time is suitable for the crowd of gastrointestinal dysfunction.
Summary of the invention
The purpose of this invention is to provide a kind of compositions, under Chinese medical theory instructed, through the rational proportion of each medical material, with the fishbone polypeptides in combination, synergism reached and improves gastrointestinal function, and the disease that gastrointestinal dysfunction is caused has good prevention effect.
Another one purpose of the present invention provides the method for preparing of said composition.
The compositions of improving gastrointestinal function of the present invention, selecting Rhizoma Typhonii, Pseudobulbus Coelogynes corymbosae, Fructus Anisi Stellati, high-spirited, Folium eucalypti globueli (Eucalyptus globulus Labill.), fishbone polypeptide is raw material; Wherein Rhizoma Typhonii is the tuber of aroid Herba Typhonii gigantei, and acrid in the mouth, sweet is warm in nature; Return stomach, Liver Channel, have the collateral dredging of eliminating the phlegm, detoxifcation analgesia effect; Pseudobulbus Coelogynes corymbosae, acrid in the mouth, sweet, cool in nature, return lung, kidney channel, have heat clearing away analgesic therapy effect; Fructus Anisi Stellati, property is hot, warm, returns liver,kidney,spleen, stomach warp, has warming YANG to expel cold, the regulating QI to relieve pain effect; High-spirited, mildly bitter flavor, property is hot, flat, has the promoting blood circulation and stopping pain effect; Folium eucalypti globueli (Eucalyptus globulus Labill.) is the leaf of myrtle Eucalyptus globulus Labill, and acrid in the mouth, hardship are cold in nature, return lung, stomach, spleen, Liver Channel, has heat-clearing and toxic substances removing, phlegm-eliminiating and qi-regulating effect; The fishbone polypeptide is the polypeptide composition that extracts in the fishbone, is rich in nutrition such as aminoacid, has fine enhance immunity effect.
Above-mentioned all raw materials share, and reach that heat clearing away is regulated the flow of vital energy, the stomach function regulating analgesic effect, to gastrointestinal dysfunction, play and improve the gastrointestinal function purpose.
The raw material consumption of preparation medicine activity component of the present invention is: Rhizoma Typhonii 3-25 part, Pseudobulbus Coelogynes corymbosae 6-30 part, Fructus Anisi Stellati 6-30 part, high-spirited 6-30 part, Folium eucalypti globueli (Eucalyptus globulus Labill.) 6-30 part, fishbone polypeptide 5-30 part.Be preferably 6 parts of Rhizoma Typhoniis, 12 parts of Pseudobulbus Coelogynes corymbosaes, 12 parts of Fructus Anisi Stellatis, 15 parts of high-spiriteds, 15 parts of Folium eucalypti globueli (Eucalyptus globulus Labill.)s, 9 parts of fishbone polypeptide.
The present composition can adopt the pharmaceutics of Chinese drugs conventional method to be prepared into conventional oral formulations.
With 6 parts of Rhizoma Typhoniis, 12 parts of Pseudobulbus Coelogynes corymbosaes, 12 parts of Fructus Anisi Stellatis, 15 parts of high-spiriteds, 15 parts of Folium eucalypti globueli (Eucalyptus globulus Labill.)s, mix according to above-mentioned weight ratio, add 8-10 times of water gaging and soaked 2-4 hour, heating decocted 1.5 hours; Filter, medicinal residues add 6-8 times of water gaging heating again and decocted 1 hour, filter, and merge filtrating twice; Left standstill 1 hour, and poured out supernatant, supernatant concentration is to relative density 1.08-1.10, and preferred density is 1.09; Advance spray dryer, 130-140 ℃ of EAT control, preferred 135 ℃, leaving air temp 100-110 ℃; Preferred 105 ℃, 40-50 rev/min of nebulizer rotating speed, preferred 45 rev/mins, charging rate is 3-5ml/ minute; Preferred 4ml/ minute, get spray drying powder, can get fine powder behind the crushing screening; This fine powder mixes with the fishbone polypeptide, is the active component of said composition.
The various conventional adjuvant of needs when this fine powder can add the preparation different dosage form like lubricant, binding agent etc., is prepared into common preparation formulation with conventional method of Chinese medicinal, like tablet, oral liquid, capsule, electuary etc.
Below in conjunction with embodiment the present invention is done further elaboration
Embodiment 1 capsule preparation of the present invention (is example with ten times of material proportional quantities)
1. take by weighing each crude drug by following weight proportion
60 parts of Rhizoma Typhoniis, 120 parts of Pseudobulbus Coelogynes corymbosaes, 120 parts of Fructus Anisi Stellatis, 150 parts of high-spiriteds, 150 parts of Folium eucalypti globueli (Eucalyptus globulus Labill.)s, 90 parts of fishbone polypeptide are subsequent use;
2. the Rhizoma Typhonii of above-mentioned weight proportion, Pseudobulbus Coelogynes corymbosae, Fructus Anisi Stellati, high-spirited, Folium eucalypti globueli (Eucalyptus globulus Labill.) add 10 times of water gagings immersions 4 hours, and heating decocted 1.5 hours, filtered; Medicinal residues add 8 times of water gaging heating again and decocted 1 hour, filter, and merge filtrating twice; Left standstill 1 hour, and poured out supernatant;
3. above-mentioned supernatant concentration to relative density is 1.1 o'clock, advances spray dryer, 140 ℃ of EAT controls, and 110 ℃ of leaving air temps, 50 rev/mins of nebulizer rotating speeds, charging rate is 5ml/ minute, gets spray drying powder;
4. above-mentioned spray drying powder is mixed with the fishbone polypeptide, adds auxiliary materials and mixing, the snap fit capsule of packing into.
Embodiment 2 preparation tablets of the present invention (is example with ten times of material proportional quantities)
1. take by weighing each crude drug by following weight proportion
250 parts of Rhizoma Typhoniis, 300 parts of Pseudobulbus Coelogynes corymbosaes, 300 parts of Fructus Anisi Stellatis, 300 parts of high-spiriteds, 300 parts of Folium eucalypti globueli (Eucalyptus globulus Labill.)s, 300 parts of fishbone polypeptide are subsequent use;
2. the Rhizoma Typhonii of above-mentioned weight proportion, Pseudobulbus Coelogynes corymbosae, Fructus Anisi Stellati, high-spirited, Folium eucalypti globueli (Eucalyptus globulus Labill.) add 8 times of water gagings immersions 2 hours, and heating decocted 1.5 hours, filtered; Medicinal residues add 6 times of water gaging heating again and decocted 1 hour, filter, and merge filtrating twice; Left standstill 1 hour, and poured out supernatant;
3. above-mentioned supernatant concentration to relative density is 1.08 o'clock, advances spray dryer, 130 ℃ of EAT controls, and 100 ℃ of leaving air temps, 40 rev/mins of nebulizer rotating speeds, charging rate is 3ml/ minute, gets spray drying powder;
4. pulverize above-mentioned spray drying powder and become fine powder, mix, add adjuvant and process granule, drying, tabletting with the fishbone polypeptide.The Ergonomy evaluation experimental of experimental example 1 Chinese medicine composition of the present invention
1. the present composition is to the influence of experiment mice small intestinal charcoal end propelling rate
48 of the healthy Kunming mouses of cleaning level, male female half and half, body weight 20 ± 2 grams; Animal is divided into 4 groups, promptly irritates the matched group that stomach gives Insta-Char, high, medium and low three dose groups of foregoing invention compositions decocting liquid, 12 every group.
Get 6 parts of Rhizoma Typhoniis, 12 parts of Pseudobulbus Coelogynes corymbosaes, 12 parts of Fructus Anisi Stellatis, 15 parts of high-spiriteds, 15 parts of Folium eucalypti globueli (Eucalyptus globulus Labill.)s, adopt conventional decocting method preparation, decocting liquid adds 9 parts of fishbone polypeptide; Mixing; The simmer down to respective concentration, medication group gastric infusion, decocting liquid various dose group comprises high dose group (20g/kg); Middle dose groups (10g/kg), low dose group (5g/kg).
Respectively organize the mice fasting before the experiment, by different group gastric infusions, all irritate stomach behind the 1h and give 5% Insta-Char (arabic gum preparation) 0.1ml/10g body weight during experiment with 10%; Put to death animal behind the 20min, cut open the belly and take out small intestinal, tractive is not tiled on the flat board; The length of measurement from the pylorus to the caecum is the small intestinal length overall; Measure the front end to the reach of charcoal end from pylorus again, calculate the percentage rate that its length accounts for the small intestinal length overall, promptly the charcoal end advances percentage rate.The charcoal end advances percentage rate=charcoal end advance distance/small intestinal length overall.The result sees the following form 1.
2. the present composition is to the influence in mice gastric emptying time
48 of the healthy Kunming mouses of cleaning level, male female half and half, body weight 20 ± 2 grams; Animal is divided into 4 groups at random, i.e. matched group, high, medium and low three dose groups of foregoing invention compositions decocting liquid, 12 every group.
Get 6 parts of Rhizoma Typhoniis, 12 parts of Pseudobulbus Coelogynes corymbosaes, 12 parts of Fructus Anisi Stellatis, 15 parts of high-spiriteds, 15 parts of Folium eucalypti globueli (Eucalyptus globulus Labill.)s, adopt conventional decocting method preparation, decocting liquid adds 9 parts of fishbone polypeptide; Mixing; The simmer down to respective concentration, medication group gastric infusion, decocting liquid various dose group comprises high dose group (20g/kg); Middle dose groups (10g/kg), low dose group (5g/kg).
Each group of experiment proxima luce (prox. luc) is by fasting 24h behind the corresponding group mediating recipe amount gastric infusion, and after 2h was administered once again before the experiment, every mouse stomach was given 0.1% methyl orange aqueous solution 0.2ml.Put to death animal behind the 20min, win stomach, place beaker, add the 10ml distilled water, stomach is cut off along greater gastric curvature, content is fully washed in the distilled water, use Na
2HCO
3Regulate Ph value 6.0-6.5; Get supernatant after centrifugal; With 741 type ultraviolet-visible photometers under wavelength 420nm; Add the 10ml distilled water with 0.1% methyl orange 0.2ml and make radix, respectively organize methyl orange trap in the mice stomach, and calculate by following formula and respectively to organize in the mice stomach average methyl orange residual rate.Methyl orange trap A/ methyl orange trap radix * 100% in methyl orange residual rate=stomach.The result sees the following form 1.
Table 1 present composition is to mouse small intestine charcoal end propelling rate and the influence in gastric emptying time
* representative is compared P＜0.05 with matched group
The present composition is obvious to methyl orange residual rate influence in the mouse small intestine charcoal end propelling rate stomach function regulating, and high, medium and low three dose groups and matched group relatively have significant difference P＜0.05.Explain that this invention compositions can promote the propelling at charcoal end in the small intestinal, reduce the residual rate of methyl orange in the stomach, point out this invention compositions can promote intestinal motility and promotion gastric peristalsis.
Claims (4)
1. compositions of improving gastrointestinal function, the active component that it is characterized in that it is to be processed by following bulk drugs: Rhizoma Typhonii 3-25 part, Pseudobulbus Coelogynes corymbosae 6-30 part, Fructus Anisi Stellati 6-30 part, high-spirited 6-30 part, Folium eucalypti globueli (Eucalyptus globulus Labill.) 6-30 part, fishbone polypeptide 5-30 part.
2. according to the compositions of claim 1, wherein the consumption of each crude drug is: 6 parts of Rhizoma Typhoniis, 12 parts of Pseudobulbus Coelogynes corymbosaes, 12 parts of Fructus Anisi Stellatis, 15 parts of high-spiriteds, 15 parts of Folium eucalypti globueli (Eucalyptus globulus Labill.)s, 9 parts of fishbone polypeptide.
3. preparation of compositions method according to claim 1 and 2 comprises the steps:
1) weighting raw materials Rhizoma Typhonii, Pseudobulbus Coelogynes corymbosae, Fructus Anisi Stellati, high-spirited, Folium eucalypti globueli (Eucalyptus globulus Labill.), fishbone polypeptide are subsequent use;
2) Rhizoma Typhonii, Pseudobulbus Coelogynes corymbosae, Fructus Anisi Stellati, high-spirited, the Folium eucalypti globueli (Eucalyptus globulus Labill.) by above-mentioned weight proportion mixes according to above-mentioned weight ratio, adds 8-10 times of water gaging and soaks 2-4 hour, and heating decocted 1.5 hours; Filter; Medicinal residues add 6-8 times of water gaging heating again and decocted 1 hour, filter, and merge filtrating twice; Left standstill 1 hour, and poured out supernatant.
3) supernatant concentration is advanced spray dryer to relative density 1.08-1.10,130-140 ℃ of EAT control, and leaving air temp 100-110 ℃, 40-50 rev/min of nebulizer rotating speed, charging rate is 3-5ml/ minute, gets spray drying powder.
4) pulverize spray drying powder, get fine powder after sieving, mix with the fishbone polypeptide, i.e. the active component of said composition.
4. method for preparing according to claim 3, the active component that step 4) is got is mixed with into solid preparations such as tablet, capsule and granule with solid preparations such as tablet, capsule, granule adjuvant commonly used.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103341009A (en) * | 2013-06-24 | 2013-10-09 | 朱颖 | Traditional Chinese medicine for treating posthepatitic cirrhosis |
| CN103340999A (en) * | 2013-07-23 | 2013-10-09 | 刘德明 | Stomach medicine and preparation method thereof |
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| CN1883684A (en) * | 2005-06-23 | 2006-12-27 | 李敬忠 | Medicinal capsule for treating gastrointestinal disease and preparation method thereof |
| CN1943754A (en) * | 2006-10-24 | 2007-04-11 | 提鑫 | A Medicine for treatment of gastrointestinal diseases |
| CN102048896A (en) * | 2009-11-02 | 2011-05-11 | 广州加原医药科技有限公司 | Traditional Chinese medicine composition for improving gastrointestinal function and preparation method thereof |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1883684A (en) * | 2005-06-23 | 2006-12-27 | 李敬忠 | Medicinal capsule for treating gastrointestinal disease and preparation method thereof |
| CN1943754A (en) * | 2006-10-24 | 2007-04-11 | 提鑫 | A Medicine for treatment of gastrointestinal diseases |
| CN102048896A (en) * | 2009-11-02 | 2011-05-11 | 广州加原医药科技有限公司 | Traditional Chinese medicine composition for improving gastrointestinal function and preparation method thereof |
Non-Patent Citations (1)
| Title |
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| 张媛等: "黄连与附子对小鼠胃肠运动的影响", 《时珍国医国药》, vol. 19, no. 10, 31 December 2008 (2008-12-31) * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103341009A (en) * | 2013-06-24 | 2013-10-09 | 朱颖 | Traditional Chinese medicine for treating posthepatitic cirrhosis |
| CN103341009B (en) * | 2013-06-24 | 2014-12-10 | 王爱芹 | Traditional Chinese medicine for treating posthepatitic cirrhosis |
| CN103340999A (en) * | 2013-07-23 | 2013-10-09 | 刘德明 | Stomach medicine and preparation method thereof |
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| CN102755635B (en) | 2014-05-28 |
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