CN105749179A - Traditional Chinese medicine composition for treating metabolic syndrome - Google Patents
Traditional Chinese medicine composition for treating metabolic syndrome Download PDFInfo
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- CN105749179A CN105749179A CN201610290023.XA CN201610290023A CN105749179A CN 105749179 A CN105749179 A CN 105749179A CN 201610290023 A CN201610290023 A CN 201610290023A CN 105749179 A CN105749179 A CN 105749179A
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- radix
- semen
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Abstract
The invention discloses traditional Chinese medicine composition for treating metabolic syndrome. The traditional Chinese medicine composition consists of the following components: radix Angelica sinensis, radix notoginseng, radix ginseng, rhizoma alismatis, folium nelumbinis, fructus mume, fiveleaf gynostemma herb, semen cassiae, bulbus allii macrostemi, cassia twig, fructus aurantii immaturus, radix saliviae miltiorrizae, rhizoma coptidis, fructus crataegi, cactus, semen raphani, semen litchi, radix astragali, aloes, poria cocos, radix stephaniae tetrandrae, cortex cinnamomi, squama manis, radix curcumae, herba leonuri, fructus amomi, radix puerariae, folium lycii, radix bupleuri, radix rehmaniae recens, fructus corni, rhizoma dioscoreae, radix trichosanthis, herba epimedii, semen strychni, semen plantaginis and the like. According to the traditional Chinese medicine composition, the components are combined and complement each other; the traditional Chinese medicine composition can be effectively used for dialectically treating the metabolic syndrome, improving blood lipid level, relieving insulin resistance and obese state, and the like; and the traditional Chinese medicine composition is convenient to prepare, small in side effect, high in safety and low in price, and provides a technical basis for research and development of metabolic syndrome and complication treatment drugs.
Description
Technical field
The invention belongs to technical field of Chinese medicines, particularly relate to the Chinese medicine composition for the treatment of metabolism syndrome.
Background technology
Metabolism syndrome refers to the pathological state of the material generation metabolism disorders such as the protein of human body, fat, carbohydrate, is a complex set of metabolism disorder disease group, is the risk factor causing diabetes cardiovascular and cerebrovascular disease.It has the following characteristics that 1. multiple metabolism disorder is rolled into one, glutinous, metabolic arthritis, higher fatty acid liver incidence rate and hyperinsulinemia including obesity, hyperglycemia, hypertension, dyslipidemia, high blood, these metabolism disorders are the pathologic basis of the heart, cerebrovascular disease and diabetes.Visible diabetes are not isolated diseases, but one of ingredient of metabolism syndrome.2. there is common pathologic basis, think that their common cause is exactly the fat insulin resistant that especially central obesity causes and hyperinsulinemia more at present.3. multiple disease can be caused to increase, such as hypertension, coronary heart disease, apoplexy, even some cancer, including the breast carcinoma relevant with gonadal hormone, carcinoma of endometrium, carcinoma of prostate, and the cancer of pancreas of digestive system, liver and gall cancer, colon cancer etc..4. there are common prevention and remedy measures, prevent and treat a kind of metabolism disorder, be also advantageous for the preventing and treating of other metabolism disorders.
Clinical commonly used drug is as treated the calcium ion antagonist (felodipine of hypertension, amlodipine, nifedipine-sr, nicardipine), ACEI preparation (enalapril, benazepril, benazepril, ramipril etc.), ARB preparation (losartan, valsartan, Candesartan, irbesartan etc.), blood sugar lowering (metformin, gliclazide, glipizide, gliquidone, rosiglitazone, pioglitazone), hypolipidemic (simvastatin, atorvastatin, fluvastatin etc.), but they are all only with the disorder correcting one aspect of metabolism syndrome.Owing to complication is many, result medicine variety is many, and judgment criteria differs, and curative effect is not fully up to expectations.Additionally, except these medicines are the basic reason for primary disease and insulin resistant except euglycemic agent, all the other medicines are all select a therapy target in syndrome, break up respectively, so certainly will occur over the course for the treatment of being respectively multiple medicines use and control, the wasting of resources, the situation that effect differs, and these medicine great majority are chemical drugs, and side effect is bigger.Finally, the traditional Chinese medical science also has taking convenience, and side effect is little, and safety is high, cheap, it is simple to long-term taking and reduce the advantages such as patient economy burden.Though having treatment metabolism syndrome multi-medicament existing, including Chinese medicine, but for various reasons, it uses and curative effect unsatisfactory, therefore, improvement on treatment metabolism syndrome medicine and innovate imperative.
Summary of the invention
It is an object of the invention to provide the Chinese medicine composition for the treatment of metabolism syndrome.The order of the present invention also resides in the preparation method and its usage of the Chinese medicine composition providing above-mentioned treatment metabolism syndrome.
In order to solve above-mentioned technical problem, the technical solution used in the present invention is as follows: the Chinese medicine composition for the treatment of metabolism syndrome is made up of each raw material components of following parts by weight proportioning:
nullThe Chinese medicine composition for the treatment of metabolism syndrome，It is made up of each component of following parts by weight: Radix Angelicae Sinensis 1-10 part、Radix Notoginseng 1-10 part、Radix Ginseng 1-8 part、Rhizoma Alismatis 2-15 part、Folium Nelumbinis 5-20 part、Fructus Mume 2-23 part、Herb Gynostemmae Pentaphylli 2-16 part、Semen Cassiae 2-15 part、Bulbus Allii Macrostemonis 2-14 part、Ramulus Cinnamomi 3-7 part、Fructus Aurantii Immaturus 2-7 part、Radix Salviae Miltiorrhizae 1-6 part、Rhizoma Coptidis 4-13 part、Fructus Crataegi 2-25 part、Radix et Caulis Opuntiae Dillenii 3-18 part、Semen Raphani 2-11 part、Semen Litchi 2-14 part、Radix Astragali 3-8 part、Aloe 2-9 part、Poria 1-6 part、Radix Stephaniae Tetrandrae 3-16 part、Cortex Cinnamomi 4-14 part、Squama Manis 1-6 part、Radix Curcumae 2-6 part、Herba Leonuri 2-18 part、Fructus Amomi 3-10 part、Radix Puerariae 4-20 part、Folium Lycii 5-20 part、Radix Bupleuri 1-4 part、Radix Rehmanniae 2-7 part、Mountain cornel 3-9 part、Rhizoma Dioscoreae 2-10 part、Radix Trichosanthis 1-7 part、Herba Epimedii 2-14 part、Semen Strychni 2-17 part、Semen Plantaginis 2-16 part、Caulis Spatholobi 2-13 part、Lignum Sappan 2-9 part、Semen Euphorbiae 3-16 part、Fructus Liquidambaris 2-10 part、Retinervus Luffae Fructus 2-10 part、Stigma Maydis 1-8 part、Semen Abutili 1-6 part、Aminoacid 0.05-2 part、Glycine betaine 0.1-4 part.
Furthermore, it is preferred that each component parts by weight proportioning is:
nullRadix Angelicae Sinensis 1-8 part、Radix Notoginseng 1-8 part、Radix Ginseng 1-8 part、Rhizoma Alismatis 2-15 part、Folium Nelumbinis 5-15 part、Fructus Mume 2-15 part、Herb Gynostemmae Pentaphylli 2-10 part、Semen Cassiae 2-10 part、Bulbus Allii Macrostemonis 2-10 part、Ramulus Cinnamomi 3-7 part、Fructus Aurantii Immaturus 2-7 part、Radix Salviae Miltiorrhizae 1-6 part、Rhizoma Coptidis 4-10 part、Fructus Crataegi 2-15 part、Radix et Caulis Opuntiae Dillenii 3-13 part、Semen Raphani 2-11 part、Semen Litchi 2-10 part、Radix Astragali 3-8 part、Aloe 2-9 part、Poria 1-6 part、Radix Stephaniae Tetrandrae 3-13 part、Cortex Cinnamomi 4-10 part、Squama Manis 1-6 part、Radix Curcumae 2-6 part、Herba Leonuri 2-18 part、Fructus Amomi 3-10 part、Radix Puerariae 4-20 part、Folium Lycii 5-15 part、Radix Bupleuri 1-4 part、Radix Rehmanniae 2-7 part、Mountain cornel 3-9 part、Rhizoma Dioscoreae 2-10 part、Radix Trichosanthis 1-7 part、Herba Epimedii 2-14 part、Semen Strychni 2-15 part、Semen Plantaginis 2-15 part、Caulis Spatholobi 2-10 part、Lignum Sappan 2-9 part、Semen Euphorbiae 3-16 part、Fructus Liquidambaris 2-10 part、Retinervus Luffae Fructus 2-10 part、Stigma Maydis 1-8 part、Semen Abutili 1-5 part、Aminoacid 0.05-2 part、Glycine betaine 0.1-4 part.
Furthermore, each component parts by weight proportioning being more highly preferred to is:
Radix Angelicae Sinensis 2 parts, Radix Notoginseng 2 parts, Radix Ginseng 1 part, Rhizoma Alismatis 2 parts, 6 parts of Folium Nelumbinis, Fructus Mume 3 parts, Herb Gynostemmae Pentaphylli 4 parts, Semen Cassiae 3 parts, Bulbus Allii Macrostemonis 2 parts, Ramulus Cinnamomi 3 parts, Fructus Aurantii Immaturus 2 parts, Radix Salviae Miltiorrhizae 1 part, Rhizoma Coptidis 4 parts, Fructus Crataegi 3 parts, Radix et Caulis Opuntiae Dillenii 4 parts, Semen Raphani 3 parts, Semen Litchi 6 parts, the Radix Astragali 3 parts, Aloe 4 parts, 1 part of Poria, Radix Stephaniae Tetrandrae 3 parts, Cortex Cinnamomi 4 parts, Squama Manis 1 part, Radix Curcumae 2 parts, Herba Leonuri 7 parts, Fructus Amomi 3 parts, Radix Puerariae 5 parts, Folium Lycii 7 parts, Radix Bupleuri 4 parts, 5 parts of the Radix Rehmanniae, mountain cornel 3 parts, Rhizoma Dioscoreae 1 part, Radix Trichosanthis 2 parts, Herba Epimedii 3 parts, Semen Strychni 4 parts, Semen Plantaginis 2 parts, Caulis Spatholobi 2 parts, Lignum Sappan 3 parts, Semen Euphorbiae 3 parts, Fructus Liquidambaris 2 parts, Retinervus Luffae Fructus 6 parts, Stigma Maydis 7 parts, Semen Abutili 1 part, 0.05 part of aminoacid, glycine betaine 0.3 part.
Furthermore, each component parts by weight proportioning being more highly preferred to is:
Radix Angelicae Sinensis 2 parts, Radix Notoginseng 4 parts, Radix Ginseng 1 part, Rhizoma Alismatis 2 parts, 8 parts of Folium Nelumbinis, Fructus Mume 7 parts, Herb Gynostemmae Pentaphylli 2 parts, Semen Cassiae 3 parts, Bulbus Allii Macrostemonis 3 parts, Ramulus Cinnamomi 4 parts, Fructus Aurantii Immaturus 4 parts, Radix Salviae Miltiorrhizae 1 part, Rhizoma Coptidis 4 parts, Fructus Crataegi 7 parts, Radix et Caulis Opuntiae Dillenii 6 parts, Semen Raphani 3 parts, Semen Litchi 7 parts, the Radix Astragali 3 parts, Aloe 5 parts, 4 parts of Poria, Radix Stephaniae Tetrandrae 3 parts, Cortex Cinnamomi 4 parts, Squama Manis 1 part, Radix Curcumae 2 parts, Herba Leonuri 7 parts, Fructus Amomi 3 parts, Radix Puerariae 4 parts, Folium Lycii 5 parts, Radix Bupleuri 4 parts, 5 parts of the Radix Rehmanniae, mountain cornel 3 parts, Rhizoma Dioscoreae 1 part, Radix Trichosanthis 2 parts, Herba Epimedii 3 parts, Semen Strychni 4 parts, Semen Plantaginis 2 parts, Caulis Spatholobi 2 parts, Lignum Sappan 3 parts, Semen Euphorbiae 3 parts, Fructus Liquidambaris 2 parts, Retinervus Luffae Fructus 6 parts, Stigma Maydis 7 parts, Semen Abutili 1 part, 0.05 part of aminoacid, glycine betaine 0.3 part.Aminoacid in above-mentioned includes the aminoacid etc. such as glutamic acid, arginine, aspartic acid, cystine, L-3,4 dihydroxyphenylalanine.
Furthermore, it is more preferred to the use of Western medicine troglitazone 0.05-1 part on the basis of above-mentioned prescription.
The one that medicine of the present invention can be prepared on any pharmaceutics in acceptable decoction, capsule, pill, tablet, powder, oral liquid, granule according to the common process of this area.
Additionally, the preparation method that present invention also offers the Chinese medicine composition of above-mentioned treatment metabolism syndrome, comprise the following steps: a) take Radix Angelicae Sinensis, Radix Notoginseng, Radix Ginseng, Rhizoma Alismatis, Folium Nelumbinis, Fructus Mume, Herb Gynostemmae Pentaphylli, Semen Cassiae, Bulbus Allii Macrostemonis, Ramulus Cinnamomi, Fructus Aurantii Immaturus, Radix Salviae Miltiorrhizae, Rhizoma Coptidis, Fructus Crataegi, Radix et Caulis Opuntiae Dillenii, Semen Raphani, Semen Litchi, the Radix Astragali, Aloe, Poria, Radix Stephaniae Tetrandrae, Cortex Cinnamomi, Squama Manis, Radix Curcumae, Herba Leonuri, Fructus Amomi, Radix Puerariae, Folium Lycii, Radix Bupleuri, the Radix Rehmanniae, mountain cornel, Rhizoma Dioscoreae, Radix Trichosanthis, Herba Epimedii, Semen Strychni, Semen Plantaginis, Caulis Spatholobi, Lignum Sappan, Semen Euphorbiae, Fructus Liquidambaris, Retinervus Luffae Fructus, Stigma Maydis, Semen Abutili medical material is cleaned, dry and pulverize；B) adding the ethanol water that volume fraction is 60%～95%, reflux, extract, twice, each 1 hour, the volume of ethanol water used was 4 times of medical material gross weight every time；C) merge alcohol extract, decompression recycling ethanol, obtain extractum, vacuum drying, obtain dry extract；D) by described extract dry, pulverize and mix homogeneously with described aminoacid, glycine betaine etc., add corresponding adjuvant and obtain final drug.
Other preferred dosage form of the present invention also can be prepared as follows method and make: by Radix Angelicae Sinensis, Radix Notoginseng, Radix Ginseng, Rhizoma Alismatis, Folium Nelumbinis, Fructus Mume, Herb Gynostemmae Pentaphylli, Semen Cassiae, Bulbus Allii Macrostemonis, Ramulus Cinnamomi, Fructus Aurantii Immaturus, Radix Salviae Miltiorrhizae, Rhizoma Coptidis, Fructus Crataegi, Radix et Caulis Opuntiae Dillenii, Semen Raphani, Semen Litchi, the Radix Astragali, Aloe, Poria, Radix Stephaniae Tetrandrae, Cortex Cinnamomi, Squama Manis, Radix Curcumae, Herba Leonuri, Fructus Amomi, Radix Puerariae, Folium Lycii, Radix Bupleuri, the Radix Rehmanniae, mountain cornel, Rhizoma Dioscoreae, Radix Trichosanthis, Herba Epimedii, Semen Strychni, Semen Plantaginis, Caulis Spatholobi, Lignum Sappan, Semen Euphorbiae, Fructus Liquidambaris, Retinervus Luffae Fructus, Stigma Maydis, Semen Abutili medical material boiling twice, add water 5-10 times amount for the first time, boil 1-5 hour；Add water 4-8 times amount for the second time, boil 0.5-3 hour, collecting decoction, filter, in 55 DEG C, filtrate is concentrated into proportion is 1.14-1.47, release concentrated solution, dilute, stand 24 hours, take supernatant and cross 300-400 mesh filter screen, concentration, adds the mix homogeneously such as aminoacid, glycine betaine etc., and then preparation process is respectively prepared corresponding capsule, pill, tablet, powder, oral liquid or granule routinely.
Present invention additionally comprises the Chinese medicine composition of described treatment metabolism syndrome or described Chinese medicine composition treats the application in the pharmaceutical preparation of metabolism syndrome with pharmaceutically acceptable pharmaceutical carrier in preparation.
Present invention additionally comprises described Chinese medicine composition or described Chinese medicine composition and treat the application in the pharmaceutical preparation of abnormal carbohydrate metabolism, central obesity, hypertension, hyperlipemia or atheromatosis with pharmaceutically acceptable pharmaceutical carrier in preparation.
By technique scheme, the present invention has the advantage that and provides the benefit that: all medicine compatibilities of the present invention, brings out the best in each other, can be effectively used for dialectical treatment metabolism syndrome, improve blood lipid level, alleviates insulin resistant and fat state etc..The present invention is easy to make, side effect is little, safety is high, cheap, the research and development for the entirety of metabolism syndrome and complications Treatment medicine provides technical foundation.
Detailed description of the invention
The core that the application is claimed with it is crucial that the compatibility of Chinese medicine composition, do not lie in dosage form, any dosage form that every this Chinese medicine composition of employing is made, belong to the scope that the present invention is claimed.Its raw material components comprised is: Radix Angelicae Sinensis, Radix Notoginseng, Radix Ginseng, Rhizoma Alismatis, Folium Nelumbinis, Fructus Mume, Herb Gynostemmae Pentaphylli, Semen Cassiae, Bulbus Allii Macrostemonis, Ramulus Cinnamomi, Fructus Aurantii Immaturus, Radix Salviae Miltiorrhizae, Rhizoma Coptidis, Fructus Crataegi, Radix et Caulis Opuntiae Dillenii, Semen Raphani, Semen Litchi, the Radix Astragali, Aloe, Poria, Radix Stephaniae Tetrandrae, Cortex Cinnamomi, Squama Manis, Radix Curcumae, Herba Leonuri, Fructus Amomi, Radix Puerariae, Folium Lycii, Radix Bupleuri, the Radix Rehmanniae, mountain cornel, Rhizoma Dioscoreae, Radix Trichosanthis, Herba Epimedii, Semen Strychni, Semen Plantaginis, Caulis Spatholobi, Lignum Sappan, Semen Euphorbiae, Fructus Liquidambaris, Retinervus Luffae Fructus, Stigma Maydis, Semen Abutili, aminoacid, glycine betaine.
Wherein, the main component of each Chinese medicinal components and effect are described below respectively:
Radix Angelicae Sinensis: sweet in the mouth is pungent, temperature, can rise and can drop, the YIN aspect of YANG is nontoxic.Though there being upper purgation to divide, enrich blood then one.Dong Yuan calls tail removing blood stasis person, by mistake.Enter the heart, spleen, liver three dirty.But its property is very dynamic, then QI invigorating in the Qi-tonifying drug entered, the hematonic entered then is enriched blood, the ascending medicine entered then carries gas, enter drop by medicine then by blood also.And with cold then tremble with fear, the Re Zere of use, nothing determines merit also.
Radix Notoginseng: nature and flavor: hardship sweet, micro-, temperature.Gui Jing: return liver, stomach warp.Function cures mainly: dissipating blood stasis stops blooding, subduing swelling and relieving pain.For spitting blood, spit blood, epistaxis, to have blood in stool, metrorrhagia, traumatic hemorrhage, chest and abdomen twinge, tumbling and swelling.
Radix Ginseng: nature and flavor: hardship sweet, micro-is flat.Gui Jing: return spleen, lung, heart channel.Function cures mainly: strongly invigorating primordial QI, and multiple arteries and veins takes off admittedly, and invigorating the spleen to benefit the lung promotes the production of body fluid, calms the nerves.For weak body and prostration, cold extremities faint pulse, insufficiency of the spleen lack of appetite, the deficiency of the lung is breathed with cough, and Tianjin wound is thirsty, and interior-heat is quenched one's thirst, prolonged illness weakness with emaciation, palpitation with fear insomnia, sexual impotence cold womb；Heart failure, cardiogenic shock.
Rhizoma Alismatis: nature and flavor: sweet, cold.Gui Jing: return kidney, bladder warp.Function cures mainly: diuresis, clearing away damp-heat.For dysuria, edema distension, oliguria of having loose bowels, dizziness due to fluid-retention, the puckery pain of pyretic stranguria；Hyperlipidemia.
Folium Nelumbinis: nature and flavor: bitter is flat.Gui Jing: return liver, spleen, stomach warp.Function cures mainly: clearing away summer-heat, sending up the lucid YANG, cooling blood for hemostasis.For summer-heat excessive thirst, diarrhea due to summer heat and dampness, diarrhea due to hypofunction of the spleen, heat in blood tells nosebleed, metrorrhagia of having blood in stool.Burnt FOLIUM NELUMBINIS astringent therapy removing stasis to stop bleeding.For multiple hemorrhage and puerperal blood faints.
Fructus Mume: nature and flavor: sour, puckery is flat.Gui Jing: return liver, spleen, lung, large intestine channel.Function cures mainly: astringe the lung, and astringing intestine to stop diarrhea promotes the production of body fluid, relieving colic caused by ascaris.For chronic cough of deficiency lung, chronic dysentery laxation, deficiency-heat is quenched one's thirst, ascariasis of biliary tract vomiting stomachache, ascariasis of biliary tract.
Herb Gynostemmae Pentaphylli: nature and flavor: bitter in the mouth；Micro-sweet；Cool in nature.Gui Jing: return lung；Spleen；Kidney channel.Function cures mainly: heat clearing away；Qi-restoratives；Removing toxic substances.Main body void is weak；Nephrasthenia emission；Leukopenia；Hyperlipemia；Viral hepatitis；Chronic gastroenteritis；Chronic tracheitis.
Semen Cassiae: nature and flavor: sweet, bitter, salty, is slightly cold.Gui Jing: return liver, large intestine channel.Function cures mainly: clearing away heat to improve acuity of vision, loosening bowel to relieve constipation.For the puckery pain of conjunctival congestion, the many tear of photophobia, dizziness of having a headache, poor vision, constipation.
Bulbus Allii Macrostemonis: nature and flavor: pungent, bitter, temperature.Gui Jing: return lung, stomach, large intestine channel.Function cures mainly: activating YANG and eliminating stagnation, circulation of qi promoting intestinal stasis relieving.For thoracic obstruction pain, phlegm retention cough with asthma, heavy after letting out dysentery.
Ramulus Cinnamomi: nature and flavor: acrid, sweet, warm.Gui Jing: GUIXIN, lung, bladder warp.Function cures mainly: diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, the flat gas that spins.For anemofrigid cold, coldness and pain in the epigastrium, cold in blood amenorrhea, arthralgia, phlegm retention, edema, cardiopalmus, renal mass.
Fructus Aurantii Immaturus: nature and flavor: bitter, pungent, sour, temperature.Gui Jing: return spleen, stomach warp.Function cures mainly: dispelling the stagnated QI removing food stagnancy, scattered painful abdominal mass of reducing phlegm.Stop in stagnant, feeling of fullness distending pain, weight, constipation, the stagnant vapour lock thoracic obstruction of expectorant, blocked-up chest after dysentery；Gastroptosis, proctoptosis, uterine prolapse.
Radix Salviae Miltiorrhizae: nature and flavor: bitter, is slightly cold.Gui Jing: GUIXIN, Liver Channel.Function cures mainly: stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, and clear away heart-fire relieving restlessness.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, chest and abdomen twinge, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia；Hepatosplenomegaly, angina pectoris.
Rhizoma Coptidis: nature and flavor: bitter, cold.Gui Jing: GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel.Function cures mainly: heat clearing and damp drying, eliminating fire and detoxication.For damp and hot feeling of fullness, vomitting acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, heat in blood tells nosebleed, conjunctival congestion, toothache, quenches one's thirst, carbuncle furuncle；External treatment eczema, eczema, auditory meatus is suppurated.It is burning hot that Rhizoma Coptidis (processed with wine) is apt to the clear part of the body cavity above the diaphragm housing the heart and lungs.For conjunctival congestion, aphtha.Prepared RHIZOMA COPTIDIS with rhizoma zingiberis recens juice clearing stomach stomach function regulating preventing or arresting vomiting.Tying mutually for cold and heat, damp and hot middle resistance, feeling of fullness is vomitted.Cornel Rhizoma Coptidis soothing liver-QI stomach function regulating preventing or arresting vomiting.For incoordination between the liver and stomach, vomit acid regurgitation.
Fructus Crataegi: nature and flavor: sour, sweet, tepor.Gui Jing: return spleen, stomach, Liver Channel.Function cures mainly: promoting digestion and invigorating the stomach, circulation of qi promoting dissipating blood stasis.For meat stagnation, gastral cavilty distension, dysentery is suffered from abdominal pain, blood stasis amenorrhea, postpartum stagnation, trusted subordinate's twinge, hernia pain；Hyperlipemia.Fructus Crataegi (parched to brown) dyspepsia and intestinal stasis relieving effect strengthens.For meat stagnation, dysentery is not well.
Radix et Caulis Opuntiae Dillenii: nature and flavor: bitter, cold.Gui Jing: " east, Fujian book on Chinese herbal medicine ": enter the heart, lung, stomach three warp.Function cures mainly: promoting flow of QI and blood, heat-clearing and toxic substances removing.Control heart peratodynia, mass in the abdomen, dysentery, hemorrhoidal bleeding, cough, laryngalgia, lung abscess, acute mastitis, furuncle, burn, snakebite.
Semen Raphani: nature and flavor: acrid in the mouth；Sweet；Property is put down.Gui Jing: spleen；Stomach；Lung；Large intestine channel.Function cures mainly: dyspepsia and intestinal stasis relieving；Lowering the adverse-rising QI to resolve phlegm.Main stagnation of QI due to dyspepsia；Distension and fullness in the abdomen；Diarrhoea；Weight after dysentery；Cough ant phlegm；QI rising in reverse order dyspnea with fullness of the chest.
Semen Litchi: the dry mature seed of sapindaceous plant Fructus Litchi LitchichinensisSonn..Summer, harvesting ripe fruit, removed peel and meat aril, cleans, dries.Nature and flavor: sweet puckery, temperature.1. " detailed outline ": " sweet, temperature, puckery, nontoxic." 2. " medical center bun is wanted ": " is sweet puckery, and temperature is micro-salty." 3. " Guangxi Chinese medicinal herbal ": " sweet and slightly bitter taste is puckery, and property is put down, nontoxic." return through: enter liver, kidney channel.1. " detailed outline ": " enter the moon of fainting." 2. " Bencao Jingshu ": " enters liver, kidney." 3. " book on Chinese herbal medicine brief points ": " enters lunar, the JUE YIN meridian of foot." function cures mainly: warming middle-JIAO, regulates the flow of vital energy, pain relieving.Control gastric abscess, colicky, women's pricking caused by the stagnation of QI and blood.1. control trusted subordinate's gastral cavilty pain of a specified duration, touch originator repeatly repeatly: Semen Litchi one money, the Radix Aucklandiae eight points.For end.Often taking a money, clear soup is taken after mixing with liquid.(Jing-Yue Complete Works litchi perfume (or spice) dissipates) 2. controls pained and small intestine-QI: Semen Litchi one piece.Forging sustainability, wine is taken after mixing with liquid, and it is big such as bucket that (amplification on Canon of Materia Medica) 3. controls kidney: Fructus Foeniculi, Pericarpium Citri Reticulatae Viride (full person), Semen Litchi decile on oceangoing ship.File dissipates, and fries, goes out fire-toxin, for end.Two money under wine, taking medicine three times daily.(Effective Formulas Tested by Physicians for Generations litchi core dissipates) is 4. controlled hernia TUI and is swollen: Semen Litchi four nineteen, and Pericarpium Citri Reticulatae (even white) nine money, sulfur four money, for end, it is big that lake, face ball Semen phaseoli radiati bought by saline.When meeting pain, hollow wine takes nine balls, takes for a good while again, also controls all pain due to disorder of QI.(" smooth celestial being all efficacious prescriptions " Yuhuan reflex is red) 5. controls pricking caused by the stagnation of QI and blood: Semen Litchi (charred medicinal herb with its property retained) half two, Rhizoma Cyperi one or two.Upper for end.Often taking two money, salt wine send down.
The Radix Astragali: nature and flavor: sweet, temperature.Gui Jing: return lung, spleen channel.Function cures mainly: invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle difficulty is burst, and bursts for a long time and does not hold back, and blood deficiency dull yellowish colored skin, interior-heat is quenched one's thirst；Chronic nephritis proteinuria, diabetes.
Aloe: nature and flavor: bitter, cold.Gui Jing: return liver, stomach, large intestine channel.Function cures mainly: removing heat from the liver, relieving constipation.For constipation, infantile malnutrition, infantile convulsion；External treatment exudative dermatitis.
Poria: nature and flavor: sweet, light is flat.Gui Jing: GUIXIN, lung, spleen, kidney channel.Function cures mainly: promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.For edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability, palpitation with fear insomnia.
Radix Stephaniae Tetrandrae: nature and flavor: bitter, cold.Gui Jing: return bladder, lung meridian.Function cures mainly: inducing diuresis to remove edema, wind-expelling pain-stopping.For edema beriberi, dysuria, eczema sore, rheumatic arthralgia；Hypertension.
Herba Dianthi: nature and flavor: bitter；Cold in nature.Gui Jing: the heart；Liver；Small intestinal；Bladder warp.Function cures mainly: diuresis；Clearing away damp-heat；Promoting blood circulation to restore menstrual flow.Main urinary obstruction；Pyretic stranguria；Stranguria with blood；Stranguria caused by urinary stone；Amenorrhea；Conjunctival congestion and swelling pain；Carbuncle sore tumefacting virus；Eczema pruritus.
Cortex Cinnamomi: nature and flavor: pungent, sweet, hot greatly.Gui Jing: return kidney, spleen, the heart, Liver Channel.Function cures mainly: mend fire supporing yang, let the fire back to its origin, dispersing cold for relieving pain, promoting blood circulation to restore menstrual flow.For sexual impotence, cold womb, chills and pain of the waist and kness, suffering from a deficiency of the kidney and breathe heavily, dizziness due to yang deficiency, conjunctival congestion pharyngalgia, trusted subordinate's cold type of pain, deficiency and coldness is vomited and diarrhoea, colic of cold type, renal mass, amenorrhea, dysmenorrhea.
Squama Manis: nature and flavor: salty, is slightly cold.Gui Jing: return liver, stomach warp.Function cures mainly: stimulating milk secretion of stimulating the menstrual flow, detumescence and apocenosis, searches wind and removing obstruction in channels.For amenorrhea abdominal mass, galactostasis, carbuncle sore tumefacting virus, arthralgia, numbness contracture.
Radix Curcumae: nature and flavor: pungent, bitter, cold.Gui Jing: return liver, the heart, lung meridian.Function cures mainly: regulating qi to disperse stagnation, heart fire-clearing upset-relieving, promoting the function of the gallbladder to alleviate jaundice.For amenorrhea dysmenorrhea, chest and abdomen swelling and pain, twinge, calentura coma, epilepsy is gone mad, jaundice dark coloured urine.
Herba Leonuri: nature and flavor: bitter, pungent, is slightly cold.Gui Jing: return liver, pericardium channel.Function cures mainly: promoting blood flow to regulate menstruation, inducing diuresis to remove edema.For menoxenia, dysmenorrhea, amenorrhea, lochiorrhea, edema oliguria；Acute nephritis edema.
Fructus Amomi: nature and flavor: pungent, temperature.Gui Jing: return spleen, stomach, kidney channel.Function cures mainly: removing dampness is whetted the appetite, warming spleen and stopping diarrha, regulates the flow of vital energy antiabortive.For turbid damp obstructing in middle-JIAO, gastral cavity painful abdominal mass is not hungry, Deficiency and coldness of spleen and stomach, and vomiting is had loose bowels, pregnancy reactions, frequent fetal movement.
Radix Puerariae: nature and flavor: sweet, pungent is cool.Gui Jing: return spleen, stomach warp.Function cures mainly: expelling pathogenic factors from muscles for reducing heat, promotes the production of body fluid, rash, yang invigorating antidiarrheal.For fever caused by exogenous pathogens headache, stiff nape and back, thirsty, quench one's thirst, measles without adequate eruption, hematodiarrhoea, have loose bowels；Hypertension neck pain.
Folium Lycii: there is antipyretic, the treatment curative effect such as diabetes, relieving cough and resolving phlegm, effect: the liver and the kidney tonifying, promoting the production of body fluid to quench thirst, expelling wind and removing dampness, blood circulation promoting and blood stasis dispelling.Control deficient fever, excessive thirst, conjunctival congestion dusk pain, nyctalopia of hiding from view, bleeding not during menses, hot carbuncle toxin.
Radix Bupleuri: nature and flavor: bitter, is slightly cold.Gui Jing: return liver, gallbladder meridian.Function cures mainly: reconciling superficies and interior, soothing the liver, yang invigorating.For cold, fever, alternate attack of chill and fever, distending pain in the chest and hypochondrium, menoxenia, sub-official prolapses, proctoptosis.
The Radix Rehmanniae: bitter but sweet flavor, gas is trembled with fear, and sinks also, and the moon is also.Start with few the moon and hands lunar.The fire of cool head, the heat of lung heat clearing liver, also monarch drug is also.Its merit is specially in cooling blood for hemostasis, and kind treatment incised wound, antiabortive gas, stimulate the menstrual flow again, and leak-stopping collapses, and all has siddhi.But cold in nature, the cold person of taste is unsuitable multiplex.Husband's Radix Rehmanniae is kind removing heat from blood both, the absurd row of warm blood, or spit blood or epistaxis or hematochezia, should use for monarch, and add Herba Schizonepetae with Gui Qijing, add Radix Notoginseng Mo Yizhiqi road, not removing of what heat and blood is more than again.But this taste can be multiplex and can not frequently use, can temporary and can not for a long time with also.Coming also when blood, its gesture is very anxious, haves no alternative but reuse the Radix Rehmanniae, stops blooding with removing heat from blood.If blood one only, namely should use the agent of temperature compensation instead, improper still enter again also with the Radix Rehmanniae.Moderns do not know its event, the god of frightened Radix Rehmanniae hemostasis, are considered as miraculous cure, everyday decoction, and then taste are too cool for a long time, must to having loose bowels, and vigour is tried out, and blood heavily comes.Not realizing the Radix Rehmanniae with many, the anti-Radix Rehmanniae of doubting, with few, still more enters, and has increasing its point two, the person of realizing till death and not, also sad also husband.
Fructus Corni: nature and flavor: sour, puckery, tepor.Gui Jing: return liver, kidney channel.Function cures mainly: liver and kidney tonifying, essence astringing and desertion stemming.For vertigo and tinnitus, soreness of waist and knee joint, impotence and seminal emission, enuresis frequent micturition, bleeding not during menses, profuse sweating is collapsed, and interior-heat is quenched one's thirst.
Rhizoma Dioscoreae: nature and flavor: sweet, flat.Gui Jing: return spleen, lung, kidney channel.Function cures mainly: spleen reinforcing nourishing the stomach, and promote the production of body fluid lung benefiting, the kidney invigorating arresting seminal emission.For insufficiency of the spleen lack of appetite, incessant chronic diarrhea, the deficiency of the lung is breathed with cough, emission due to deficiency of the kidney, leukorrhagia, frequent micturition, and deficiency-heat is quenched one's thirst.Rhizoma Dioscoreae (parched with bran) spleen reinforcing stomach invigorating.For insufficiency of the spleen lack of appetite, loose stool of having loose bowels, leukorrhagia.
Radix Trichosanthis: bitter in the mouth, cold in nature.Controlling lung abscess, evacuation of pus, disappear excessive thirst, only lung-heat, the traumatic injury that disappears blood stasis, the with the passing of time old expectorant yellow sputum in Qinghua, the therapeutic method to keep the adverse QI flowing downwards, solution sore, controls ulcerative carbuncle toxic swelling, and cough-relieving is coughed band blood.
Herba Epimedii: nature and flavor: acrid, sweet, warm.Gui Jing: return liver, kidney channel.Function cures mainly: kidney-replenishing, bone and muscle strengthening, wind-damp dispelling.For impotence and seminal emission, muscles and bones flaccidity is soft, rheumatic arthralgia, numbness contracture；Climacteric hypertension.:
Semen Strychni: nature and flavor: bitter, temperature；Very toxic.Gui Jing: return liver, spleen channel.Function cures mainly: removing obstruction in the collateral to relieve pain, mass dissipating and swelling eliminating.For rheumatoid arthritis stubborn, paralysis and numbness, injury from falling down, ulcer sore pain；Poliomyelitis sequela, rheumatoid arthritis.
Semen Plantaginis: nature and flavor are sweet, cold.Can clearing away heat and promoting diuresis, liver heat removing and eyesight improving, expelling phlegm for arresting cough, eliminating dampness by diuresis antidiarrheal.Suitable in damp and hot interior strongly fragrant edema；The frequent micturition of appearance, urgent micturition, dysurea during urinary system infection；Summer-heat is had loose bowels, bacillary dysentery；Conjunctival congestion and swelling pain caused by liver-heat, keeps in dark place and sheds tears, blurring of vision.
Caulis Spatholobi: nature and flavor: bitter sweet, temperature.1. " decoction pieces is newly joined ": " pained fragrant micro-sweet." 2. " book on Chinese herbal medicine justice ": " temperature." 3. Jiangxi " Chinese herbology ": " bitter temperature is micro-sweet." return through: " book on Chinese herbal medicine is new again ": " enters the heart, spleen two warp." function cures mainly: invigorate blood circulation, relaxing muscles and tendons.Control soreness of waist and knee joint, paralysis and numbness, menoxenia.1. " detailed outline is picked up any lost article from the road ": " invigorate blood circulation, warm waist knee joint, paralysis." 2. " book on Chinese herbal medicine is new again ": " dry stomach of invigorating middle warmer." 3. " decoction pieces is newly joined ": " blood stasis removing blood, tissue regeneration promoting blood, fluent passages through which vital energy circulates.Control summer filthy infection, wind arthralgia due to stagnation of blood disease." 4. " modern Practical Chinese medicinal ": " is the hematonic of robustness, it is adaptable to anemicus neural paralysis disease, such as limbs and soreness of waist and knee joint, apathy etc..Again for menoxenia, menstruation apolipsis etc., there is the effect of invigorating blood circulation analgesia.″
Lignum Sappan: nature and flavor: sweet, salty, flat.Gui Jing: GUIXIN, liver, spleen channel.Function cures mainly: promoting the circulation of blood blood stasis dispelling, reducing swelling and alleviating pain.For amenorrhea dysmenorrhea, postpartum stagnation, chest and abdomen twinge, wound swells and ache.
Semen Euphorbiae: nature and flavor: pungent, warm；Poisonous.Gui Jing: return liver, kidney, large intestine channel.Function cures mainly: detumescence of relieving oedema or abdominal distension through diuresis or purgation, removing blood stasis eliminating mass.For edema, phlegm retention, stagnant distension, constipation and anuresis, blood stasis amenorrhea；External treatment stubborn dermatitis, warty vegetation.
Fructus Liquidambaris: nature and flavor: bitter is flat.Gui Jing: return liver, kidney channel.Function cures mainly: dispelling, collateral-activating, and diuretic stimulates the menstrual flow.For arthralgia, numbness contracture, edema distension, the few amenorrhea of breast.
Retinervus Luffae Fructus: nature and flavor: sweet is flat.Gui Jing: return lung, stomach, Liver Channel.Function cures mainly: dredging collateral, invigorates blood circulation, and dispels the wind.For arthralgia pain contracture, distending pain in the chest and hypochondrium, galactostasis.
Stigma Maydis: nature and flavor: sweet, light is flat.Gui Jing: return bladder, liver, gallbladder meridian.Function cures mainly: inducing diuresis to remove edema, suppressing the hyperactive liver function of gallbladder promoting.For acute and chronic nephritis, edema, acute hepatitis, chronic hepatitis, hypertension, diabetes, chronic sinusitis, lithangiuria, Biliary Calculi, the disease such as dysuria, damp and hot jaundice.And habitual abortion can be prevented.
Semen Abutili: nature and flavor: sweet；Cold.Gui Jing: large intestine；Small intestinal；Liver；Lung；Stomach；Bladder warp.Function cures mainly: relieving stranguria by diuresis；Laxation relieving constipation；Stimulating milk secretion.Main gonorrhea；Edema；Constipation；Breast antiperspirant is not all right.
Glycine betaine: antitumor, blood pressure lowering, anti-peptic ulcer and gastrointestinal dysfunction, treat hepatic disease.As feed additive, there is offer methyl donor function, some methionine can be saved.There is the internal osmotic pressure of adjustment, mitigation stress, promote lipid metabolism and protein synthesis, improve the function of lean meat percentage, and the curative effect of anticoccidial drug can be strengthened.
Below by way of concrete preferred embodiment, the present invention is described in further detail, but the present invention is not limited in below example.
Embodiment 1
Radix Angelicae Sinensis 2 parts, Radix Notoginseng 2 parts, Radix Ginseng 1 part, Rhizoma Alismatis 2 parts, 6 parts of Folium Nelumbinis, Fructus Mume 3 parts, Herb Gynostemmae Pentaphylli 4 parts, Semen Cassiae 3 parts, Bulbus Allii Macrostemonis 2 parts, Ramulus Cinnamomi 3 parts, Fructus Aurantii Immaturus 2 parts, Radix Salviae Miltiorrhizae 1 part, Rhizoma Coptidis 4 parts, Fructus Crataegi 3 parts, Radix et Caulis Opuntiae Dillenii 4 parts, Semen Raphani 3 parts, Semen Litchi 6 parts, the Radix Astragali 3 parts, Aloe 4 parts, 1 part of Poria, Radix Stephaniae Tetrandrae 3 parts, Cortex Cinnamomi 4 parts, Squama Manis 1 part, Radix Curcumae 2 parts, Herba Leonuri 7 parts, Fructus Amomi 3 parts, Radix Puerariae 5 parts, Folium Lycii 7 parts, Radix Bupleuri 4 parts, 5 parts of the Radix Rehmanniae, mountain cornel 3 parts, Rhizoma Dioscoreae 1 part, Radix Trichosanthis 2 parts, Herba Epimedii 3 parts, Semen Strychni 4 parts, Semen Plantaginis 2 parts, Caulis Spatholobi 2 parts, Lignum Sappan 3 parts, Semen Euphorbiae 3 parts, Fructus Liquidambaris 2 parts, Retinervus Luffae Fructus 6 parts, Stigma Maydis 7 parts, Semen Abutili 1 part, 0.05 part of aminoacid, glycine betaine 0.3 part.
The preparation method of the Chinese medicine composition of above-mentioned treatment metabolism syndrome, comprise the following steps: a) take Radix Angelicae Sinensis, Radix Notoginseng, Radix Ginseng, Rhizoma Alismatis, Folium Nelumbinis, Fructus Mume, Herb Gynostemmae Pentaphylli, Semen Cassiae, Bulbus Allii Macrostemonis, Ramulus Cinnamomi, Fructus Aurantii Immaturus, Radix Salviae Miltiorrhizae, Rhizoma Coptidis, Fructus Crataegi, Radix et Caulis Opuntiae Dillenii, Semen Raphani, Semen Litchi, the Radix Astragali, Aloe, Poria, Radix Stephaniae Tetrandrae, Cortex Cinnamomi, Squama Manis, Radix Curcumae, Herba Leonuri, Fructus Amomi, Radix Puerariae, Folium Lycii, Radix Bupleuri, the Radix Rehmanniae, mountain cornel, Rhizoma Dioscoreae, Radix Trichosanthis, Herba Epimedii, Semen Strychni, Semen Plantaginis, Caulis Spatholobi, Lignum Sappan, Semen Euphorbiae, Fructus Liquidambaris, Retinervus Luffae Fructus, Stigma Maydis, Semen Abutili medical material is cleaned, dry and pulverize；B) adding the ethanol water that volume fraction is 60%～95%, reflux, extract, twice, each 1 hour, the volume of ethanol water used was 4 times of medical material gross weight every time；C) merge alcohol extract, decompression recycling ethanol, obtain extractum, vacuum drying, obtain dry extract；D) by described extract dry, pulverize and mix homogeneously with described aminoacid, glycine betaine etc., add the corresponding adjuvant of tablet and obtain tablet medicine.
Embodiment 2
Radix Angelicae Sinensis 2 parts, Radix Notoginseng 4 parts, Radix Ginseng 1 part, Rhizoma Alismatis 2 parts, 8 parts of Folium Nelumbinis, Fructus Mume 7 parts, Herb Gynostemmae Pentaphylli 2 parts, Semen Cassiae 3 parts, Bulbus Allii Macrostemonis 3 parts, Ramulus Cinnamomi 4 parts, Fructus Aurantii Immaturus 4 parts, Radix Salviae Miltiorrhizae 1 part, Rhizoma Coptidis 4 parts, Fructus Crataegi 7 parts, Radix et Caulis Opuntiae Dillenii 6 parts, Semen Raphani 3 parts, Semen Litchi 7 parts, the Radix Astragali 3 parts, Aloe 5 parts, 4 parts of Poria, Radix Stephaniae Tetrandrae 3 parts, Cortex Cinnamomi 4 parts, Squama Manis 1 part, Radix Curcumae 2 parts, Herba Leonuri 7 parts, Fructus Amomi 3 parts, Radix Puerariae 4 parts, Folium Lycii 5 parts, Radix Bupleuri 4 parts, 5 parts of the Radix Rehmanniae, mountain cornel 3 parts, Rhizoma Dioscoreae 1 part, Radix Trichosanthis 2 parts, Herba Epimedii 3 parts, Semen Strychni 4 parts, Semen Plantaginis 2 parts, Caulis Spatholobi 2 parts, Lignum Sappan 3 parts, Semen Euphorbiae 3 parts, Fructus Liquidambaris 2 parts, Retinervus Luffae Fructus 6 parts, Stigma Maydis 7 parts, Semen Abutili 1 part, 0.05 part of aminoacid, glycine betaine 0.3 part.
The preparation method of the Chinese medicine composition of above-mentioned treatment metabolism syndrome, comprise the following steps: by Radix Angelicae Sinensis, Radix Notoginseng, Radix Ginseng, Rhizoma Alismatis, Folium Nelumbinis, Fructus Mume, Herb Gynostemmae Pentaphylli, Semen Cassiae, Bulbus Allii Macrostemonis, Ramulus Cinnamomi, Fructus Aurantii Immaturus, Radix Salviae Miltiorrhizae, Rhizoma Coptidis, Fructus Crataegi, Radix et Caulis Opuntiae Dillenii, Semen Raphani, Semen Litchi, the Radix Astragali, Aloe, Poria, Radix Stephaniae Tetrandrae, Cortex Cinnamomi, Squama Manis, Radix Curcumae, Herba Leonuri, Fructus Amomi, Radix Puerariae, Folium Lycii, Radix Bupleuri, the Radix Rehmanniae, mountain cornel, Rhizoma Dioscoreae, Radix Trichosanthis, Herba Epimedii, Semen Strychni, Semen Plantaginis, Caulis Spatholobi, Lignum Sappan, Semen Euphorbiae, Fructus Liquidambaris, Retinervus Luffae Fructus, Stigma Maydis, Semen Abutili medical material boiling twice, add water 5-10 times amount for the first time, boil 1-5 hour；Add water 4-8 times amount for the second time, boil 0.5-3 hour, collecting decoction, filter, in 55 DEG C, filtrate is concentrated into proportion is 1.14-1.47, release concentrated solution, dilute, stand 24 hours, take supernatant and cross 300-400 mesh filter screen, concentration, adds the mix homogeneously such as aminoacid, glycine betaine etc., and then preparation process makes oral liquid routinely.
Embodiment 3
nullRadix Angelicae Sinensis 2 parts、Radix Notoginseng 4 parts、Radix Ginseng 1 part、Rhizoma Alismatis 2 parts、8 parts of Folium Nelumbinis、Fructus Mume 7 parts、Herb Gynostemmae Pentaphylli 2 parts、Semen Cassiae 3 parts、Bulbus Allii Macrostemonis 3 parts、Ramulus Cinnamomi 4 parts、Fructus Aurantii Immaturus 4 parts、Radix Salviae Miltiorrhizae 1 part、Rhizoma Coptidis 4 parts、Fructus Crataegi 7 parts、Radix et Caulis Opuntiae Dillenii 6 parts、Semen Raphani 3 parts、Semen Litchi 7 parts、The Radix Astragali 3 parts、Aloe 5 parts、4 parts of Poria、Radix Stephaniae Tetrandrae 3 parts、Cortex Cinnamomi 4 parts、Squama Manis 1 part、Radix Curcumae 2 parts、Herba Leonuri 7 parts、Fructus Amomi 3 parts、Radix Puerariae 4 parts、Folium Lycii 5 parts、Radix Bupleuri 4 parts、5 parts of the Radix Rehmanniae、Mountain cornel 3 parts、Rhizoma Dioscoreae 1 part、Radix Trichosanthis 2 parts、Herba Epimedii 3 parts、Semen Strychni 4 parts、Semen Plantaginis 2 parts、Caulis Spatholobi 2 parts、Lignum Sappan 3 parts、Semen Euphorbiae 3 parts、Fructus Liquidambaris 2 parts、Retinervus Luffae Fructus 6 parts、Stigma Maydis 7 parts、Semen Abutili 1 part、0.05 part of aminoacid、Glycine betaine 0.3 part、Troglitazone 0.05 part.
The preparation method of the Chinese medicine composition of above-mentioned treatment metabolism syndrome, comprise the following steps: by Radix Angelicae Sinensis, Radix Notoginseng, Radix Ginseng, Rhizoma Alismatis, Folium Nelumbinis, Fructus Mume, Herb Gynostemmae Pentaphylli, Semen Cassiae, Bulbus Allii Macrostemonis, Ramulus Cinnamomi, Fructus Aurantii Immaturus, Radix Salviae Miltiorrhizae, Rhizoma Coptidis, Fructus Crataegi, Radix et Caulis Opuntiae Dillenii, Semen Raphani, Semen Litchi, the Radix Astragali, Aloe, Poria, Radix Stephaniae Tetrandrae, Cortex Cinnamomi, Squama Manis, Radix Curcumae, Herba Leonuri, Fructus Amomi, Radix Puerariae, Folium Lycii, Radix Bupleuri, the Radix Rehmanniae, mountain cornel, Rhizoma Dioscoreae, Radix Trichosanthis, Herba Epimedii, Semen Strychni, Semen Plantaginis, Caulis Spatholobi, Lignum Sappan, Semen Euphorbiae, Fructus Liquidambaris, Retinervus Luffae Fructus, Stigma Maydis, Semen Abutili medical material boiling twice, add water 5-10 times amount for the first time, boil 1-5 hour；Add water 4-8 times amount for the second time, boil 0.5-3 hour, collecting decoction, filter, in 55 DEG C, filtrate is concentrated into proportion is 1.14-1.47, release concentrated solution, dilute, stand 24 hours, take supernatant and cross 300-400 mesh filter screen, concentration, adds the mix homogeneously etc. such as aminoacid, glycine betaine, troglitazone, and then preparation process is respectively prepared corresponding capsule routinely.
One, toxicity test
1, application mice carries out acute toxicity testing and shows: the Chinese medicine preparation oral liquid of the Mouse oral gavage present invention, under 488.8g crude drug/kg dosage, after administration, mice occurs that light activity reduces, 1 hours recovers normal, Continuous Observation 7 days after administration, none animal dead, its overall health of patients, diet, take the photograph water, urine and body weight increase all normal, test result indicate that: the maximum dosage-feeding of the Chinese medicine preparation oral liquid of the Mouse oral gavage present invention is 488.8g crude drug/kg/d (LD50 > 488.8g crude drug/kg).The Chinese medicine preparation clinical application every day total amount of the present invention is 0.1g crude drug/kg/d；By weighing machine, the dosis tolerata of the Chinese medicine preparation of the mouse stomach present invention is 4888 times of clinical patient.Point out this medicine acute toxicity low, clinical drug safety.
2, SD rat is selected, give the Chinese medicine preparation pill of the present invention of variable concentrations (18.0,6.0,2.0g crude drug/kg), every day gavage once, continuous 90 days, last is administered latter 24 hours respectively to organize to live and kills 1/2 animal (male and female half and half), and all the other 1/2 animals continuation are lived after observing 2 weeks and killed.Observe the outward appearance of animal, general behavior, food ration, body weight change during test, be administered latter 90 days and drug withdrawal carries out the index checking such as hematology's (RBC, HB, reticulocyte, PLT, CT, WBC and classification) and blood biochemical (AST, ALT, ALP, Glu, BUN, Crea, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, histopathology for 2 weeks.Result of the test shows: the Chinese medicine preparation of the present invention is good at high, medium and low dosage treated animal general state, and outward appearance sign, behavioral activity, food-intake and body weight increase change all without exception；Three dosage groups and matched group hematological examination, blood biochemical analysis, urine biochemical analysis all between normal range, group without significant difference；Each group main organs histopathological examination shows no obvious abnormalities.These parameters drug withdrawal also had no change after 2 weeks.180,60,20 times of this test dosage respectively clinical medicine dose, rat is had no significant effect by the Chinese medicine preparation according to the result of the test present invention in high, medium and low three dosage (18.0,6.0,2.0g crude drug/kg) administration in continuous 90 days, without clear and definite toxicity target organ and sensitive indicator, convalescent period observes and also has no retardance toxic reaction, and the dose safety of the Chinese medicine preparation clinical practice of the prompting present invention is higher.
Two, blood fat reducing effect experiment
Materials and methods
1.1 Experimental Animals Male Wistar rats 60, SPF level, body weight (150 ± 20) g, free diet.Adaptability enters experiment after feeding 7 days.Rat is randomly divided into two groups according to body weight: matched group, experimental group, often group 10.Wistar rat 60 only all feeds high fat high-carbonhydrate diet (58% normal diet+15% Adeps Sus domestica+15% sucrose+2% cholesterol).
Experimental group takes the medicine of embodiment 1, the crude drug amount 6g crude drug/kg/ of rat unit body weight, and medicine dissolution, in rat drinking water, adjusts dosage according to body weight and amount of drinking water every day.Matched group takes rosiglitazone, and two matched groups give isopyknic common drinking water, continues 12 weeks.
1.2 statistical procedures the data obtaineds are analyzed through statistics software SPSS13.0.With ± s, each group data all represent that multiple comparisons one factor analysis of variance between measurement data sample average compares between group and checks with t.P < 0.05 is statistically significant.
2. experimental result
It is shown that after the present invention and rosiglitazone in treating, to insulin resistance rat blood glucose, insulin metabolism, liver function, the impact of renal function is as follows:
| Packet | Matched group | Experimental group |
| BS | 14.3±1.13 | 10.2±0.91 |
| Ins | 9.9±2.11 | 8.1±1.9 |
| ISI | 4.5±0.16 | 2.8±0.23 |
| CP | 0.03±0.06 | 0.01±0.01 8 --> |
| SGPT | 24±4.93 | 27±3.49 |
| CCR | 61±13 | 54±13 |
As seen from the above table, the present invention treats compared with rosiglitazone, and health giving quality is suitable, and hepatic and renal function is all had no adverse effects.
The impact on rats with metabolic syndrome serum insulin and insulin resistance index of table 2 present composition
| Packet | INS(mU/L) | HONA-IR |
| Matched group | 0.860±0.213※ | 1.93±0.113※ |
| Experimental group | 0.506±0.140※※△ | 1.61±0.134※※△ |
Experiments show that, rat blood serum insulin and insulin resistance index are had significant impact by Chinese medicine composition of the present invention, can be effectively used for treatment metabolism syndrome, and try out through clinical practice, achieve very satisfied Advantageous Effects.
Two, the clinical observation of Drug therapy metabolism syndrome of the present invention
The medication combined fasting of the present invention observes 68 example Metabolic Syndrome Patients clinically, and result shows that overweight/obesity and associated metabolic disease are had good therapeutic effect by this medication combined fasting.Use procedure has no hypoglycemic reaction and other untoward reaction.
(1) metabolic syndrome diagnostic criteria was by diabetes branch of Chinese Medical Association (CSS) diagnostic criteria in 2004: possess following 3 or above person.(1) overweight and (or) fat: BMI >=25kg/m2；(2) blood fat disorder: fasting blood TG >=1.7mmol/L, and (or) fasting blood HDL-C man < 0.9mmol/L or female < 1.0mmol/L person, (or) make a definite diagnosis blood fat disorder person；(3) hyperglycemia: FPG >=6.1mmol/L (110mg/dl) and (or) 2hPG >=7.8mmol/L (140mg/dl), (or) person that is diagnosed as treating diabetes；(4) hypertension: SBP/DBP >=140/90mmHg, and (or) it is diagnosed as hyperpietic.
(2) case inclusive criteria
1 diagnostic criteria meeting metabolic syndrome；Between 2 age 18-70 years.
(3) case exclusion standard
1 age is the patient of under-18s or more than 70 years old；2 have Diabetic Acute complications (including diabetic Hypoglycemia, diabetic hyperosmolar coma, Diabetic ketosis and ketoacidosis, diabetic lactoacidosis, Diabetic Acute infection) in nearly 1 month；3 merge the infull patient of severe cardiac, Liver and kidney function；4 mental diseases fail partner；5 pregnant or age of sucking and preparation gravid woman；6 noncooperationists (refer to coordinate fasting maybe can not take Chinese medicine and the person of affecting the treatment by regulation)；7 malignant tumor and inpatient with haematological diseases；8 active tuberculosis patients；The ulcers of 9 serious gastrorrhagias；101 diabetes mellitus types；112 patients with type Ⅰ DM control bad, it is necessary to insulin injection patient；12 essential hypertension enalapril meleates control not good, secondary hypertension patient；13 researcheres are deemed unsuitable for other situation into group.
(4) all patients of Therapeutic Method all sign Informed Consent Form before starting treatment, are all maintaining on the basis of former treatment, are carrying out fasting (strict diet control) and add this Chinese medicine, one month course for the treatment of.
(5) observation index
1 curative effect index body weight, waistline, blood pressure, blood fat, change of blood sugar.
2 safety indexes hypoglycemic incidence, hunger intensity and curative compliance, hepatic and renal function, routine blood test.
(6) Comprehensive Clinical the standard of curative effect evaluation
Effective: weight loss more than 3.5 kilograms after month, blood fat, blood glucose, blood pressure are all obviously improved earlier above.
Effective: weight loss more than 2 kilograms after month, improve before all relatively fasting of blood fat, blood glucose, blood pressure.
Invalid: not reach above standard person.
(7) result
1 body weight and waistline change
In 100 example overweight/obesity persons, male's weight average declines more than 11 kilograms；Women on average declines more than 15 kilograms；Women waistline declines inconspicuous, it is possible to more with women waist and belly capsule meat, measures not accurate enough relevant.
2 Blood Lipid
| Project | Number | Before treatment | After treatment |
| TC(mmom/L) | 100 | 7.29±2.01 | 3.81±0.16 |
| HDL-c(mmom/L) | 100 | 0.96±0.21 | 1.08±0.43 |
| LDL-c(mmom/L) | 100 | 4.23±0.46 | 2.24±0.14 |
| TG(mmom/L) | 100 | 5.84±1.06 | 1.39±1.04 |
3 change of blood sugar
| Project | Number | Before treatment | After treatment |
| FBG(mmom/L) | 100 | 9.24±1.23 | 6.4±1.46 |
| P0.5hBG(mmom/L) | 100 | 14.7±3.21 | 10.6±1.94 |
| P2hBG(mmom/L) | 100 | 12.3±3.14 | 6.7±1.45 |
4 Evaluation of Synthetic Effect of Holistics
The medication combined fasting of the present invention observes 100 example Metabolic Syndrome Patients clinically, wherein effective 72 examples, effective 26 examples, invalid 2 examples.
Metabolism syndrome is had good therapeutic effect by the medication combined fasting of the present invention, and without obvious adverse reaction；Can greatly improve the ability of the resistance to hunger of patient and accept the compliance of diet control.
The above, it it is only presently preferred embodiments of the present invention, not the present invention is done any pro forma restriction, therefore it is every without departing from technical solution of the present invention content, according to any simple modification, equivalent variations and modification that above example is made by the technical spirit of the present invention, all still fall within the scope of technical solution of the present invention.
Claims (10)
- null1. treat the Chinese medicine composition of metabolism syndrome，It is characterized in that: be made up of each component of following parts by weight: Radix Angelicae Sinensis 1-10 part、Radix Notoginseng 1-10 part、Radix Ginseng 1-8 part、Rhizoma Alismatis 2-15 part、Folium Nelumbinis 5-20 part、Fructus Mume 2-23 part、Herb Gynostemmae Pentaphylli 2-16 part、Semen Cassiae 2-15 part、Bulbus Allii Macrostemonis 2-14 part、Ramulus Cinnamomi 3-7 part、Fructus Aurantii Immaturus 2-7 part、Radix Salviae Miltiorrhizae 1-6 part、Rhizoma Coptidis 4-13 part、Fructus Crataegi 2-25 part、Radix et Caulis Opuntiae Dillenii 3-18 part、Semen Raphani 2-11 part、Semen Litchi 2-14 part、Radix Astragali 3-8 part、Aloe 2-9 part、Poria 1-6 part、Radix Stephaniae Tetrandrae 3-16 part、Cortex Cinnamomi 4-14 part、Squama Manis 1-6 part、Radix Curcumae 2-6 part、Herba Leonuri 2-18 part、Fructus Amomi 3-10 part、Radix Puerariae 4-20 part、Folium Lycii 5-20 part、Radix Bupleuri 1-4 part、Radix Rehmanniae 2-7 part、Mountain cornel 3-9 part、Rhizoma Dioscoreae 2-10 part、Radix Trichosanthis 1-7 part、Herba Epimedii 2-14 part、Semen Strychni 2-17 part、Semen Plantaginis 2-16 part、Caulis Spatholobi 2-13 part、Lignum Sappan 2-9 part、Semen Euphorbiae 3-16 part、Fructus Liquidambaris 2-10 part、Retinervus Luffae Fructus 2-10 part、Stigma Maydis 1-8 part、Semen Abutili 1-6 part、Aminoacid 0.05-2 part、Glycine betaine 0.1-4 part.
- 2. the Chinese medicine composition for the treatment of metabolism syndrome according to claim 1, it is characterised in that: it is made up of each component of following parts by weight:nullRadix Angelicae Sinensis 1-8 part、Radix Notoginseng 1-8 part、Radix Ginseng 1-8 part、Rhizoma Alismatis 2-15 part、Folium Nelumbinis 5-15 part、Fructus Mume 2-15 part、Herb Gynostemmae Pentaphylli 2-10 part、Semen Cassiae 2-10 part、Bulbus Allii Macrostemonis 2-10 part、Ramulus Cinnamomi 3-7 part、Fructus Aurantii Immaturus 2-7 part、Radix Salviae Miltiorrhizae 1-6 part、Rhizoma Coptidis 4-10 part、Fructus Crataegi 2-15 part、Radix et Caulis Opuntiae Dillenii 3-13 part、Semen Raphani 2-11 part、Semen Litchi 2-10 part、Radix Astragali 3-8 part、Aloe 2-9 part、Poria 1-6 part、Radix Stephaniae Tetrandrae 3-13 part、Cortex Cinnamomi 4-10 part、Squama Manis 1-6 part、Radix Curcumae 2-6 part、Herba Leonuri 2-18 part、Fructus Amomi 3-10 part、Radix Puerariae 4-20 part、Folium Lycii 5-15 part、Radix Bupleuri 1-4 part、Radix Rehmanniae 2-7 part、Mountain cornel 3-9 part、Rhizoma Dioscoreae 2-10 part、Radix Trichosanthis 1-7 part、Herba Epimedii 2-14 part、Semen Strychni 2-15 part、Semen Plantaginis 2-15 part、Caulis Spatholobi 2-10 part、Lignum Sappan 2-9 part、Semen Euphorbiae 3-16 part、Fructus Liquidambaris 2-10 part、Retinervus Luffae Fructus 2-10 part、Stigma Maydis 1-8 part、Semen Abutili 1-5 part、Aminoacid 0.05-2 part、Glycine betaine 0.1-4 part.
- 3. the Chinese medicine composition for the treatment of metabolism syndrome according to claim 1 and 2, it is characterised in that: it is made up of each component of following parts by weight:Radix Angelicae Sinensis 2 parts, Radix Notoginseng 2 parts, Radix Ginseng 1 part, Rhizoma Alismatis 2 parts, 6 parts of Folium Nelumbinis, Fructus Mume 3 parts, Herb Gynostemmae Pentaphylli 4 parts, Semen Cassiae 3 parts, Bulbus Allii Macrostemonis 2 parts, Ramulus Cinnamomi 3 parts, Fructus Aurantii Immaturus 2 parts, Radix Salviae Miltiorrhizae 1 part, Rhizoma Coptidis 4 parts, Fructus Crataegi 3 parts, Radix et Caulis Opuntiae Dillenii 4 parts, Semen Raphani 3 parts, Semen Litchi 6 parts, the Radix Astragali 3 parts, Aloe 4 parts, 1 part of Poria, Radix Stephaniae Tetrandrae 3 parts, Cortex Cinnamomi 4 parts, Squama Manis 1 part, Radix Curcumae 2 parts, Herba Leonuri 7 parts, Fructus Amomi 3 parts, Radix Puerariae 5 parts, Folium Lycii 7 parts, Radix Bupleuri 4 parts, 5 parts of the Radix Rehmanniae, mountain cornel 3 parts, Rhizoma Dioscoreae 1 part, Radix Trichosanthis 2 parts, Herba Epimedii 3 parts, Semen Strychni 4 parts, Semen Plantaginis 2 parts, Caulis Spatholobi 2 parts, Lignum Sappan 3 parts, Semen Euphorbiae 3 parts, Fructus Liquidambaris 2 parts, Retinervus Luffae Fructus 6 parts, Stigma Maydis 7 parts, Semen Abutili 1 part, 0.05 part of aminoacid, glycine betaine 0.3 part.
- null4. the Chinese medicine composition for the treatment of metabolism syndrome according to any one of claim 1 to 3，It is characterized in that: Radix Angelicae Sinensis 2 parts、Radix Notoginseng 4 parts、Radix Ginseng 1 part、Rhizoma Alismatis 2 parts、8 parts of Folium Nelumbinis、Fructus Mume 7 parts、Herb Gynostemmae Pentaphylli 2 parts、Semen Cassiae 3 parts、Bulbus Allii Macrostemonis 3 parts、Ramulus Cinnamomi 4 parts、Fructus Aurantii Immaturus 4 parts、Radix Salviae Miltiorrhizae 1 part、Rhizoma Coptidis 4 parts、Fructus Crataegi 7 parts、Radix et Caulis Opuntiae Dillenii 6 parts、Semen Raphani 3 parts、Semen Litchi 7 parts、The Radix Astragali 3 parts、Aloe 5 parts、4 parts of Poria、Radix Stephaniae Tetrandrae 3 parts、Cortex Cinnamomi 4 parts、Squama Manis 1 part、Radix Curcumae 2 parts、Herba Leonuri 7 parts、Fructus Amomi 3 parts、Radix Puerariae 4 parts、Folium Lycii 5 parts、Radix Bupleuri 4 parts、5 parts of the Radix Rehmanniae、Mountain cornel 3 parts、Rhizoma Dioscoreae 1 part、Radix Trichosanthis 2 parts、Herba Epimedii 3 parts、Semen Strychni 4 parts、Semen Plantaginis 2 parts、Caulis Spatholobi 2 parts、Lignum Sappan 3 parts、Semen Euphorbiae 3 parts、Fructus Liquidambaris 2 parts、Retinervus Luffae Fructus 6 parts、Stigma Maydis 7 parts、Semen Abutili 1 part、0.05 part of aminoacid、Glycine betaine 0.3 part.
- 5. the Chinese medicine composition of the treatment metabolism syndrome according to Claims 1-4, it is characterised in that: also include troglitazone 0.05-1 part.
- 6. the Chinese medicine composition for the treatment of metabolism syndrome according to claim 1, it is characterised in that: dosage form is the one in decoction, capsule, pill, tablet, powder, oral liquid, granule.
- 7. the preparation method of the Chinese medicine composition for the treatment of metabolism syndrome according to claim 1, it is characterized in that: comprise the following steps: a) take Radix Angelicae Sinensis, Radix Notoginseng, Radix Ginseng, Rhizoma Alismatis, Folium Nelumbinis, Fructus Mume, Herb Gynostemmae Pentaphylli, Semen Cassiae, Bulbus Allii Macrostemonis, Ramulus Cinnamomi, Fructus Aurantii Immaturus, Radix Salviae Miltiorrhizae, Rhizoma Coptidis, Fructus Crataegi, Radix et Caulis Opuntiae Dillenii, Semen Raphani, Semen Litchi, the Radix Astragali, Aloe, Poria, Radix Stephaniae Tetrandrae, Cortex Cinnamomi, Squama Manis, Radix Curcumae, Herba Leonuri, Fructus Amomi, Radix Puerariae, Folium Lycii, Radix Bupleuri, the Radix Rehmanniae, mountain cornel, Rhizoma Dioscoreae, Radix Trichosanthis, Herba Epimedii, Semen Strychni, Semen Plantaginis, Caulis Spatholobi, Lignum Sappan, Semen Euphorbiae, Fructus Liquidambaris, Retinervus Luffae Fructus, Stigma Maydis, Semen Abutili medical material is cleaned, dry and pulverize；B) adding the ethanol water that volume fraction is 60%～95%, reflux, extract, twice, each 1 hour, the volume of ethanol water used was 4 times of medical material gross weight every time；C) merge alcohol extract, decompression recycling ethanol, obtain extractum, vacuum drying, obtain dry extract；D) by described extract dry, pulverize and mix homogeneously with described aminoacid, glycine betaine etc., add corresponding adjuvant and obtain final drug.
- 8. the preparation method of the Chinese medicine composition for the treatment of metabolism syndrome according to claim 1, it is characterized in that: comprise the following steps: by Radix Angelicae Sinensis, Radix Notoginseng, Radix Ginseng, Rhizoma Alismatis, Folium Nelumbinis, Fructus Mume, Herb Gynostemmae Pentaphylli, Semen Cassiae, Bulbus Allii Macrostemonis, Ramulus Cinnamomi, Fructus Aurantii Immaturus, Radix Salviae Miltiorrhizae, Rhizoma Coptidis, Fructus Crataegi, Radix et Caulis Opuntiae Dillenii, Semen Raphani, Semen Litchi, the Radix Astragali, Aloe, Poria, Radix Stephaniae Tetrandrae, Cortex Cinnamomi, Squama Manis, Radix Curcumae, Herba Leonuri, Fructus Amomi, Radix Puerariae, Folium Lycii, Radix Bupleuri, the Radix Rehmanniae, mountain cornel, Rhizoma Dioscoreae, Radix Trichosanthis, Herba Epimedii, Semen Strychni, Semen Plantaginis, Caulis Spatholobi, Lignum Sappan, Semen Euphorbiae, Fructus Liquidambaris, Retinervus Luffae Fructus, Stigma Maydis, Semen Abutili medical material boiling twice, add water 5-10 times amount for the first time, boil 1-5 hour；Add water 4-8 times amount for the second time, boil 0.5-3 hour, collecting decoction, filter, in 55 DEG C, filtrate is concentrated into proportion is 1.14-1.47, release concentrated solution, dilute, stand 24 hours, take supernatant and cross 300-400 mesh filter screen, concentration, adds the mix homogeneously such as aminoacid, glycine betaine etc., and then preparation process is respectively prepared corresponding capsule, pill, tablet, powder, oral liquid or granule routinely.
- 9. the Chinese medicine composition for the treatment of metabolism syndrome according to claim 1 or described Chinese medicine composition and the pharmaceutically acceptable pharmaceutical carrier application in the pharmaceutical preparation of preparation treatment metabolism syndrome.
- 10. application according to claim 9, it is characterized in that, described Chinese medicine composition or described Chinese medicine composition treat the application in the pharmaceutical preparation of abnormal carbohydrate metabolism, central obesity, hypertension, hyperlipemia or atheromatosis with pharmaceutically acceptable pharmaceutical carrier in preparation.
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| CN106138785A (en) * | 2016-08-08 | 2016-11-23 | 青岛友诚高新技术有限公司 | One treats neurasthenic Chinese medicine composition and preparation method thereof |
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| CN106138785A (en) * | 2016-08-08 | 2016-11-23 | 青岛友诚高新技术有限公司 | One treats neurasthenic Chinese medicine composition and preparation method thereof |
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| CN106166276A (en) * | 2016-08-11 | 2016-11-30 | 青岛友诚高新技术有限公司 | The Chinese medicine composition for the treatment of eczema |
| CN106491874A (en) * | 2017-01-03 | 2017-03-15 | 山西医科大学 | A kind of Chinese medicine composition for suppressing intestinal endotoxemia |
| CN106962944A (en) * | 2017-05-12 | 2017-07-21 | 上海诺鼎生物科技有限公司 | A kind of nutritious food powder of weight-reducing |
| CN107259557A (en) * | 2017-07-21 | 2017-10-20 | 杜亚东 | A kind of nutrient powder of weight-reducing |
| CN107184859A (en) * | 2017-07-25 | 2017-09-22 | 江西熙帝生物科技有限公司 | A kind of composition with three high drop and anti-trioxypurine |
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