CN105738247A - Air pressure detecting method for thrombelastogram and special detecting cup thereof - Google Patents
Air pressure detecting method for thrombelastogram and special detecting cup thereof Download PDFInfo
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- CN105738247A CN105738247A CN201610106327.6A CN201610106327A CN105738247A CN 105738247 A CN105738247 A CN 105738247A CN 201610106327 A CN201610106327 A CN 201610106327A CN 105738247 A CN105738247 A CN 105738247A
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N7/00—Analysing materials by measuring the pressure or volume of a gas or vapour
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Abstract
An air pressure detecting method for a thrombelastogram is characterized by comprising the following steps that firstly, blood samples to be detected are put into a detecting cup which is divided into a left part and a right part through an isolation rib, and then the detecting cup is sealed through two butyl rubber stoppers; secondly, two hollow needles are inserted into the butyl rubber stoppers respectively, an electromagnetic valve on the right hollow needle is turned off so that air on the right side can be in a sealed state; thirdly, a precise micro-air pump is operated to regularly adjust the right side, and a gas micro-pressure sensor ceaselessly records the gas pressure value of the sealed space in the detecting cup 1; fourthly, the micro-pressure sensor draws a pressure diagram, namely the thrombelastogram, of the whole coagulation process according to all the data recorded in the blood sample solidification thickening period. The special detecting cup for the air pressure detecting method for the thrombelastogram is characterized in that the isolating rib is arranged in the middle of the detecting cup, the bottom of the isolating rib is 3-5mm away from the bottom of the detecting cup, and the two butyl rubber stoppers are arranged at the upper end of the detecting cup.
Description
Technical field
The present invention relates to medical science, the air pressure detection method of a kind of thrombelastogram and dedicated test cup thereof.
Background technology
Blood coagulation, i.e. blood coagulation, refer to that blood is become the process of the most flowable gel state by the liquid condition flowed, and is the important step of physiological haemostasis.Hemostasis examination content is blood coagulation four at present, checks project and monitoring clinical oral administration anticoagulant patient before must looking into project, thrombosis for operation consent.Blood coagulation four includes prothrombin time, activated partial thromboplastin time, thrombin time, Fibrinogen.Compared to the end-point method of blood coagulation four, thrombelastogram can dynamic reflection thrombin, fibrin, platelet function and fibrinolytic situation, and the time greatly shortened, general ten a few minutes just can obtain result.But the Probe-detection methods that thrombelastogram instrument is used at present is applied for a patent by offshore company, domestic clinical research is badly in need of developing the brand-new dynamic testing method of a kind of thrombelastogram, so that thrombelastogram detection is promoted in China and develops.
Summary of the invention
For background technology problem encountered, it is an object of the invention to provide a kind of detection method using air pressure to measure thrombelastogram continuously and dedicated test cup thereof, change China's thrombelastogram instrument market and only have the present situation of foreign technology and instrument.
In order to achieve the above object, the present invention adopts the following technical scheme that the air pressure detection method of a kind of thrombelastogram, it is characterised in that described detection method comprises the following steps:
Blood sample to be detected is inserted and is divided in the two-part detection in left and right cup with isolation bar by Step 1., is then sealed by detection cup by two butyl rubber plugs；
Step 2. uses two hollow needles to insert butyl rubber plug respectively, makes the air of this side be in sealing state by closing electromagnetic valve the hollow needle on right side；
Step 3. regularly regulates right side by operation precise micro air pump, and gas micro-pressure sensor uninterrupted recording surveys the gas pressure value in cup 1 inner sealing space simultaneously；
Micro-pressure sensor is depicted the tonogram of whole coagulation process, i.e. thrombelastogram along with all data that recorded during blood sample solidification retrogradation by Step 4..
Further, being provided with isolation bar in the middle of described detection cup, from 3-5mm at the bottom of detection cup cup bottom described isolation bar, described detection cup upper end is provided with two butyl rubber plugs, it is ensured that the aeroseal in detection cup.
Further, described butyl rubber plug being inserted with the hollow needle of two vertical layouts, described hollow needle upper end connects two horizontally disposed hollow pipes, and the end of described hollow pipe is provided with air filter, prevents blood sample quality to be detected to be affected.
Further, from connection hollow needle position to the air filter of hollow pipe end, gas micro-pressure sensor, the air pumping pipe vertically arranged and electromagnetic gas valve it is sequentially provided with on the hollow pipe of described side, air pump can be utilized to change the pressure of the gas detecting cup, each measurement data of sensor record simultaneously.
Further, described air pumping pipe is sequentially provided with precise micro air pump and air filter from bottom to up, it is ensured that blood sample is not by air pollution.
Accompanying drawing explanation
Fig. 1 is that air pressure of the present invention measures thrombelastogram detection used cup structure figure continuously；
Fig. 2 is the detection method schematic diagram that air pressure of the present invention measures thrombelastogram continuously；
The drawing reference numeral explanation of detailed description of the invention:
1, detection cup, 2, isolation bar, the 3, first butyl rubber plug, 4, the second butyl rubber plug, 5, blood sample, the 6, first hollow needle, 7, the first hollow pipe, the 8, first air filter, the 9, second hollow needle, 10, the second hollow pipe, 11, gas micro-pressure sensor, 12, precise micro air pump, 13, electromagnetic gas valve, 14, the second air filter, the 15, the 3rd air filter.
Detailed description of the invention
In order to be better understood from the purpose of the present invention, structure, feature and effect etc., in conjunction with the drawings and specific embodiments, the invention will be further described.
A kind of air pressure being illustrated in figure 1 the present invention measures thrombelastogram detection used cup continuously, it chamber including detection cup 1 is divided into two bottom connections by isolation bar 2, the top of two chambers is equiped with the first butyl rubber plug 3 respectively and the second butyl rubber plug 4 seals, and the blood sample 5 of collection leaves the bottom of detection cup 1 in.
The detection method of thrombelastogram is measured continuously as Fig. 2 show a kind of air pressure of the present invention, it includes that the first hollow needle 6 inserts in the first butyl rubber plug 3, the other end of the first hollow needle 6 is equiped with the first hollow pipe 7, first hollow pipe 7 communicates through the first air filter 8 with air, second hollow needle 9 inserts in the second butyl rubber plug 4, the other end of the second hollow needle 9 is equiped with the second hollow pipe 10, second air hose 10 communicates through electromagnetic gas valve 13 and the second air filter 14 with air, gas micro-pressure sensor 11 and precise micro air pump 12 it is equiped with on hollow pipe 10, another interface of precise micro air pump 12 is equiped with the 3rd air filter 15, the other end of the 3rd air filter 15 communicates with air.
The specific embodiment of the invention is as follows, after detection cup 1 sucks blood sample 5, first hollow needle 6 and the second hollow needle 9 are inserted respectively in the first butyl rubber plug 3 and the second butyl rubber plug 4, at this moment close electromagnetic gas valve 13 and make the air seal on the right side of detection cup 1, start the regular gas pressure increased and reduce detection cup 1 inner sealing space of precise micro air pump 12, gas micro-pressure sensor 11 uninterrupted recording surveys the gas pressure value in cup 1 inner sealing space simultaneously, retrogradation is constantly solidified and locomotivity declines along with blood sample 5, the data that gas micro-pressure sensor 11 detects every time the most constantly increase, then along with blood sample 5 continuous fibrinolytic, locomotivity rises, the data that gas micro-pressure sensor 11 detects every time the most constantly reduce, thus depict whole coagulation process.
Detailed description above is only the explanation of the preferred embodiments of the invention, non-the scope of the claims therefore limiting to the present invention, so, the equivalence techniques change that all utilization this creation description and diagramatic content are done, it is both contained in the scope of the claims of the present invention.
Claims (5)
1. the air pressure detection method of a thrombelastogram, it is characterised in that described detection method comprises the following steps:
Blood sample to be detected is inserted and is divided in the two-part detection in left and right cup with isolation bar by Step 1., is then sealed by detection cup by two butyl rubber plugs；
Step 2. uses two hollow needles to insert butyl rubber plug respectively, makes the air of this side be in sealing state by closing electromagnetic valve the hollow needle on right side；
Step 3. regularly regulates right side by operation precise micro air pump, and gas micro-pressure sensor uninterrupted recording surveys the gas pressure value in cup 1 inner sealing space simultaneously；
Micro-pressure sensor is depicted the tonogram of whole coagulation process, i.e. thrombelastogram along with all data that recorded during blood sample solidification retrogradation by Step 4..
The air pressure detection method dedicated test cup of a kind of thrombelastogram the most according to claim 1, it is characterised in that: being provided with isolation bar in the middle of described detection cup, from 3-5mm at the bottom of detection cup cup bottom described isolation bar, described detection cup upper end is provided with two butyl rubber plugs.
The air pressure detection method dedicated test cup of a kind of thrombelastogram the most according to claim 2, it is characterized in that: on described butyl rubber plug, be inserted with the hollow needle of two vertical layouts, described hollow needle upper end connects two horizontally disposed hollow pipes, and the end of described hollow pipe is provided with air filter.
The air pressure detection method dedicated test cup of a kind of thrombelastogram the most according to claim 2, it is characterised in that: from connection hollow needle position to the air filter of hollow pipe end, it is sequentially provided with gas micro-pressure sensor, the air pumping pipe vertically arranged and electromagnetic gas valve on the hollow pipe of described side.
The air pressure detection method dedicated test cup of a kind of thrombelastogram the most according to claim 4, it is characterised in that: described air pumping pipe is sequentially provided with precise micro air pump and air filter from bottom to up.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610106327.6A CN105738247B (en) | 2016-02-26 | 2016-02-26 | A kind of the air pressure detection method and its dedicated test cup of thrombelastogram |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610106327.6A CN105738247B (en) | 2016-02-26 | 2016-02-26 | A kind of the air pressure detection method and its dedicated test cup of thrombelastogram |
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| CN105738247A true CN105738247A (en) | 2016-07-06 |
| CN105738247B CN105738247B (en) | 2019-02-01 |
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| CN201610106327.6A Active CN105738247B (en) | 2016-02-26 | 2016-02-26 | A kind of the air pressure detection method and its dedicated test cup of thrombelastogram |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107462628A (en) * | 2017-09-14 | 2017-12-12 | 重庆南方数控设备有限责任公司 | A kind of thrombus detection device for elasticity and detection method based on magnetic |
| CN110261589A (en) * | 2019-07-18 | 2019-09-20 | 深圳优迪生物技术有限公司 | Thrombelastogram instrument based on micro- resistance |
| CN111912737A (en) * | 2019-05-07 | 2020-11-10 | 重庆南方数控设备有限责任公司 | Method and device for detecting solidification of viscoelastic solution |
Citations (5)
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| US3911728A (en) * | 1973-02-19 | 1975-10-14 | Daillet S A Ets | Coagulation detection apparatus |
| US4780418A (en) * | 1985-11-19 | 1988-10-25 | Michael Kratzer | Method and apparatus for measuring the aggregation of blood platelets or the coagulation of blood |
| CN1239775A (en) * | 1998-06-23 | 1999-12-29 | 山东工业大学 | Measurement method and device for non-anticoagulant apparent viscosity of blood |
| CN202229992U (en) * | 2011-10-25 | 2012-05-23 | 中国石油天然气股份有限公司 | Device breaking through vacuity gelometry |
| CN103245774A (en) * | 2012-02-07 | 2013-08-14 | 奥索临床诊断有限公司 | Method for determining centrifugal blood conditions through measured pressure |
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2016
- 2016-02-26 CN CN201610106327.6A patent/CN105738247B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3911728A (en) * | 1973-02-19 | 1975-10-14 | Daillet S A Ets | Coagulation detection apparatus |
| US4780418A (en) * | 1985-11-19 | 1988-10-25 | Michael Kratzer | Method and apparatus for measuring the aggregation of blood platelets or the coagulation of blood |
| CN1239775A (en) * | 1998-06-23 | 1999-12-29 | 山东工业大学 | Measurement method and device for non-anticoagulant apparent viscosity of blood |
| CN202229992U (en) * | 2011-10-25 | 2012-05-23 | 中国石油天然气股份有限公司 | Device breaking through vacuity gelometry |
| CN103245774A (en) * | 2012-02-07 | 2013-08-14 | 奥索临床诊断有限公司 | Method for determining centrifugal blood conditions through measured pressure |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107462628A (en) * | 2017-09-14 | 2017-12-12 | 重庆南方数控设备有限责任公司 | A kind of thrombus detection device for elasticity and detection method based on magnetic |
| CN111912737A (en) * | 2019-05-07 | 2020-11-10 | 重庆南方数控设备有限责任公司 | Method and device for detecting solidification of viscoelastic solution |
| CN111912737B (en) * | 2019-05-07 | 2023-09-26 | 重庆南方数控设备有限责任公司 | Method and device for detecting solidification of viscoelastic solution |
| CN110261589A (en) * | 2019-07-18 | 2019-09-20 | 深圳优迪生物技术有限公司 | Thrombelastogram instrument based on micro- resistance |
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| CN105738247B (en) | 2019-02-01 |
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Effective date of registration: 20161229 Address after: 430050 Hubei City, Wuhan District, Hanyang District, the city is the number of street, room 92, No. 302 Applicant after: Liu Yong Address before: 430000 Hubei province Wuhan Hannan Economic Development Zone (Wuhan high source Biological Technology Development Co. Ltd.) No. 2 building 1-2 Applicant before: WUHAN DONGFANG HUAKANG TECHNOLOGY CO., LTD. |
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